研究・業績 研究・業績

研究・業績

  • 下肢スポーツ・関節機能温存／研究

  • 業績
下肢スポーツ・関節機能温存グループ
▲下肢スポーツ・関節機能温存グループ
【臨床研究】
◆膝関節靭帯損傷、スポーツ外傷
膝前十字靱帯（ACL）損傷の治療は、これまでの臨床および基礎研究をもとに、基本的にはハムストリングス腱を用いた解剖学的二重束再建術を継続して行っておりますが、症例に応じて骨付き膝蓋腱や大腿四頭筋腱を用いた再建術も行っています。ACL再建膝の評価は、当科で開発した三次元電磁気センサーを用いて再建術前後の膝キネマティクスや術後成績の詳細を解析しております。手術成績は概ね安定していますが、これまでの再建手術症例の成績を調査して術後再断裂や不安定性残存に関連した因子の同定し、さらなる術後成績の向上を目指して臨床研究を行っています。
骨端線閉鎖前のACL損傷に対しては、経過観察期間中の半月板や軟骨損傷などの二次的な損傷の危険性と手術による成長障害の危険性の両方を慎重に判断しつつ再建術も積極的に行っています。また、カナダをはじめとした海外施設と国際的多施設共同研究を行っています。ACL再建術後の膝機能回復やスポーツ復帰までの重要な役割を果たしてくれているリハビリテーション部の理学療法士の先生方と共にリハビリテーションの側面からの評価も行っています。特に、筋力や患者立脚型評価、心理的側面などに関する詳細な解析を行っており、術後のスポーツ復帰において患者満足度や恐怖感の影響ついて検討し論文報告しております。

◆軟骨損傷、半月板損傷、変形性関節症、膝蓋骨脱臼
半月板損傷に関しては、関節鏡下半月板縫合術を第一選択として行っています。断裂形態に応じて、縫合糸や機器も工夫して縫合し、可能な限り半月板縫合を行い半月板の温存に努めております。軟骨損傷に対する治療としては、主には自家骨軟骨柱移植術を用いて行っていますが、欠損範囲の広い症例では、自家培養軟骨細胞移植（ジャック®）を行っております。また、ジャックの変形性膝関節症（OA）に対する治療効果を調べる臨床比較試験や、単独軟骨損傷に対する骨膜パッチを要しない培養軟骨細胞移植術を治験として行っています。
OAの治療として人工関節に至る前の中高年の活動性の高い方には 積極的に膝周囲骨切り術を行っております。現在は変形の形態や下肢アライメントの状態に応じて様々な骨切り術を用いて治療を行っております。内側型OAに対してはOAの進行の程度に応じて、Open-wedge HTO、Distal Tuberosity Osteotomy、Hybrid closed HTO、Double-level osteotomy、Tibial Condylar Valgus Osteotomyといった手術方法を、外側型OAに対してDistal femoral osteotomyなど症例に応じて使い分け、より幅広く対応できるように手術を行っております。OAの進行に重要な内側半月板後根損傷に対しても保存治療を含めて計画的にフォローアップし、悪化傾向のある症例に対しては関節温存すべく手術的治療を行っています。半月板後根損傷は、しばしば臨床現場で見過ごされていることがあり、早期発見、早期治療の重要性を啓蒙しておりおります。
膝蓋骨脱臼に対しては基本的には内側膝蓋大腿靭帯（MPFL）再建術を施行しており、再脱臼率は低く安定した成績が得られております。高度脱臼素因を有する反復性膝蓋骨脱臼、習慣性膝蓋骨脱臼、恒久性脱臼といった特殊な症例の場合は脛骨粗面移行術や滑車形成術、骨切り術、大腿四頭筋腱延長など様々な手術を組合わせて治療を行っています。

◆足の外科
足の外科は整形外科の中でも特殊性が高い分野になりますが、保存療法だけでなく、最新の器材や手術法を取り入れながら、関節鏡を用いた低侵襲手術も積極的に行っており、様々な競技のスポーツ選手に対して治療を行っております。最も頻度の高いスポーツ傷害の一つである足関節外側靭帯損傷に対しては、近年術式が開発され徐々に広がりつつある関節鏡視下の靭帯修復術（鏡視下Brostrom法）をいち早く導入し積極的に行っております。また、人工靭帯や自家腱を用いた靱帯再建術なども行っており、距骨骨軟骨損傷に対して同時に治療を行うことも多くあります。内視鏡は足関節だけでなく、距骨下関節（足根洞）や後足部（三角骨障害）、癒合部、足底腱膜、後脛骨筋腱や腓骨筋腱鞘内、母趾MTP関節とさまざまな部位に使用し低侵襲治療を積極的に行っており、従来の直視下法に比べて格段に早いスポーツ復帰が可能となっております。
変形性足関節症に対しては、鏡視下滑膜切除術や低位脛骨骨切り術、足関節固定術（関節鏡視下）、人工足関節置換術などの手術を行っておりますが、それらの手術も患者様の変形の程度やご年齢、活動性などを考慮し、ひとりひとりに最も適した方法で治療を行っております。特に、末期の変形性足関節症や関節リウマチに対して積極的に人工足関節置換術を行っており（年間20～30件）、安定した成績が得られております。距骨の圧潰を認めるものや距骨下関節の関節症性変化が強いものに対しては、人工距骨を併用した人工足関節置換術も行っており、日本有数の症例数を誇っております。人工足関節置換術と人工距骨を併用した人工足関節置換術の術後臨床成績を比較調査し、論文にて報告しております。さらに、手術器具の研究・新規開発にも力を注いでおります。
外反扁平足（後脛骨筋腱機能不全）に対しても積極的に手術を行っており、踵骨内方移動骨切り、外側支柱延長、腱移行術、二関節または三関節固定術などを組み合わせて加療しており、人工足関節置換術との併用も行っております。外反母趾などの前足部変形につきましては保存療法による除痛を第一としており、効果に乏しければ水平骨切り術をメインに手術を行っております。
基礎研究では、膝関節で以前より使用している三次元電磁気センサーシステムを足関節に応用し、低侵襲かつ正確に、足関節の可動域や前方引き出しといった関節動態の定量的評価の研究を行っております。また、人工知能（AI）を用いて、足関節外側不安定症における超音波装置を用いた前方引き出しテストの評価について検討しております。
【基礎研究】
生物学的な基礎研究では、軟骨細胞の変性制御機構の解明、OAの病態、治療、半月板再生などに関連した基礎的研究を引き続き行っております。長寿因子SIRT1ノックインマウスにおけるOA進行抑制効果に関する研究は2021年に論文掲載されました。現在、mTOR抑制剤の膝OA進行抑制効果に関する研究や内側半月板後根損傷の病態に関する動物モデルを用いた研究を行っております。また、OAに対する脂肪由来細胞の治療効果メカニズムに関連した基礎的研究をまとめ2021年に論文報告致しました。さらに、膝周囲骨切り術前後の関節内変化に関連した研究もおこなっております。
バイオメカニクスに関連する研究としては、前十字靭帯損傷で近年使用されてきている大腿四頭筋腱の移植腱の固定方法に関する研究を福井大学工学部の長宗准教授との共同研究で、2021年に論文報告いたしました。また、以前から行っている三次元電磁気センサーシステムを用いた研究では、ACL損傷に伴ったキネマティクスの変化や、前外側回旋不安定性と骨形態や前外側支持機構損傷との関連などにつき調査しております。三次元的な画像解析を用いたACL再建術時の骨孔評価や、骨切り術前後の評価などに関する研究も行っています。これらの研究成果は日本整形外科学会、日本関節鏡・膝・スポーツ整形外科学会（JOSKAS）、日本臨床バイオメカニクス学会、日本臨床スポーツ医学会、アメリカ整形外科学会（AAOS）、アメリカ整形外科基礎学会（ORS）、国際関節症学会（OARSI）、国際軟骨治療学会（ICRS）、国際組織再生工学・再生医療会議（TERMIS）、アメリカスポーツ整形外科学会（AOSSM）、ヨーロッパ関節鏡・膝・スポーツ整形外科学会（ESSKA）、国際関節鏡・膝・スポーツ整形外科学会（ISAKOS）等で報告するとともに、論文発表を行っております。

  • 下肢スポーツ・関節機能温存／業績

  • 研究
英文原著論文（2019年以降）
(1) Eliya Y, Qureshi AR, Kay J, Nagai K, Hoshino Y, de Sa D. Anatomical double-bundle anterior cruciate ligament reconstruction moderately improved tegner scores over the long-term: a systematic review and meta-analysis of randomized controlled trials. Knee Surg Sports Traumatol Arthrosc. 2023 Feb;31(2):436-448.

(2) Singh H, Glassman I, Sheean A, Hoshino Y, Nagai K, de SA D. Less than 1% risk of donor-site quadriceps tendon rupture post-ACL reconstruction with quadriceps tendon autograft: a systematic review. Knee Surg Sports Traumatol Arthrosc. 2023 Feb;31(2):572-585.

(3) Nukuto K, Matsushita T, Kamada K, Nishida K, Nagai K, Kanzaki N, Hoshino Y, Matsumoto T, Niikura T, Kuroda R. Development and analysis of mouse medial meniscus posterior root tear model. Calcif Tissue Int. 2023;112(1):55-65.

(4) Nagai K, Kamada K, Kay J, Hoshino Y, Matsushita T, Kuroda R, de Sa D. Clinical Outcomes After Anterior Cruciate Ligament Reconstruction in Patients With a Concomitant Segond Fracture: A Systematic Review. Am J Sports Med. 2023 Feb;51(2):525-533.

(5) Kamada K, Matsushita T, Nagai K, Hoshino Y, Araki D, Kanzaki N, Matsumoto T, Niikura T, Kuroda R. Risk factors of residual pivot-shift after anatomic double-bundle anterior cruciate ligament reconstruction. Arch Orthop Trauma Surg. 2023 Feb;143(2):977-985.

(6) Vivekanantha P, Kahlon H, Shahabinezhad A, Cohen D, Nagai K, Hoshino Y, de SA D. Tibial tubercle to trochlear groove distance versus tibial tubercle to posterior cruciate ligament distance for predicting patellar instability: a systematic review. Knee Surg Sports Traumatol Arthrosc. 2023 Aug;31(8):3243-3258.

(7) Diao YD, Vivekanantha P, Cohen D, Hoshino Y, Nagai K, de SA D. Patients with discoid menisci have similar clinical outcomes to those without discoid menisci when undergoing surgical intervention: a systematic review. Knee Surg Sports Traumatol Arthrosc. 2023 Aug;31(8):3369-3380.

(8) Kihara S, Kanzaki N, Yamashita T, Yamamoto T, Nishida K, Nagai K, Araki D, Hoshino Y, Matsushita T, Kuroda R. Talar component subsidence correlates with periprosthetic osteolysis after total ankle arthroplasty. Eur J Orthop Surg Traumatol. 2023 Oct;33(7):2987-2993.

(9) Nakanishi Y, Matsushita T, Nagai K, Araki D, Hoshino Y, Kuroda R. Fibrin clot and Leukocyte-rich platelet-rich fibrin show similar release kinetics and amount of growth factors: a pilot study. J Orthop Surg Res. 2023 Mar 25;18(1):238.

(10) Ueda Y, Matsushita T, Shibata Y, Takiguchi K, Ono K, Kida A, Nishida K, Nagai K, Hoshino Y, Matsumoto T, Sakai Y, Kuroda R. Combining age, sex, body mass index, sport level, and preoperative quadriceps strength improves the predictive ability of quadriceps strength recovery after anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc. 2023 Oct;31(10):4390-4398.

(11) Yavari E, Moosa S, Cohen D, Cantu-Morales D, Nagai K, Hoshino Y, de Sa D. Technology-assisted anterior cruciate ligament reconstruction improves tunnel placement but leads to no change in clinical outcomes: a systematic review and meta-analysis. Knee Surg Sports Traumatol Arthrosc. 2023 Oct;31(10):4299-4311.

(12) Vivekanantha P, Diao YD, Kay J, Hoshino Y, Nagai K, de Sa D. Partial debridement is the most commonly reported treatment option for mucoid degeneration of the anterior cruciate ligament: a systematic review. Knee Surg Sports Traumatol Arthrosc. 2023 Oct;31(10):4265-4275.

(13) Watanabe S, Matsushita T, Nishida K, Nagai K, Hoshino Y, Matsumoto T, Kuroda R. Knee osteotomy decreases joint inflammation based on synovial histology and synovial fluid analysis. Arthroscopy. 2023 Jul 18:S0749-8063(23)00556-X.

(14) Vivekanantha P, Nedaie S, Grzela P, Cohen D, Hoshino Y, Nagai K, Kay J, de Sa D. Though Five-Strand Hamstring Autografts Demonstrate Greater Graft Diameter, Postoperative Outcomes are Equivocal to Four-Strand Hamstring Autograft Preparations: A Systematic Review and Meta-Analysis of Level I and II Studies. Knee Surg Sports Traumatol Arthrosc. Knee Surg Sports Traumatol Arthrosc. 2023 Oct;31(10):4437-4447.

(15) Nagai K, Kamada K, Kay J, Hoshino Y, Matsushita T, Kuroda R, de Sa D. Clinical Outcomes After Anterior Cruciate Ligament Reconstruction in Patients With a Concomitant Segond Fracture: Response. Am J Sports Med. 2023 Oct;51(12):NP48-NP49.

(16) Watanabe S, Nagai K, Hoshino Y, Kataoka K, Nakanishi Y, Araki D, Kanzaki N, Matsushita T, Kuroda R. Influence of Injury to the Kaplan Fibers of the Iliotibial Band on Anterolateral Rotatory Knee Laxity in Anterior Cruciate Ligament Injury: A Retrospective Cohort Study. Am J Sports Med. 2022;50(12):3265-3272.

(17) Yamashita T, Nagai K, Kanzaki N, Yamamoto T, Ibaraki K, Araki D, Hoshino Y, Matsushita T, Kuroda R. Short-term clinical outcomes following total ankle arthroplasty without concomitant osteotomy in ankles with severe preoperative varus deformity: comparison to ankles with preoperative neutral alignment. J Am Podiatr Med Assoc 2022;112(6):1-9.

(18) Kamada K, Nagai K, Nagamune K, Hoshino Y, Nakanishi Y, Araki D, Kanzaki N, Matsushita T, Kuroda R. Direct suturing quadriceps tendon to a continuous loop with a suspensory button provides biomechanically superior fixation in ACL reconstruction. Knee Surg Sports Traumatol Arthrosc. 2022;30(7):2307-2313.

(19) Byrne KJ, Rothrauff BB, Nagai K, Onishi K, Fu FH. Two-fragment Segond fracture validates historical descriptions of independent soft tissue attachments. Knee Surg Sports Traumatol Arthrosc 2022;30(1):71-77.

(20) Yamamoto T, Nagai K, Kanzaki N, Kataoka K, Nukuto K, Hoshino Y, Matsushita T, Kuroda R. Comparison of Clinical Outcomes Between Ceramic-Based Total Ankle Arthroplasty with Ceramic Total Talar Prosthesis and Ceramic-Based Total Ankle Arthroplasty. Foot Ankle Int. 2022;43(4):529-539.

(21) Matsushita T, Matsumoto T, Araki D, Nagai K, Hoshino Y, Niikura T, Kawamoto A, Go MJ, Kawamata S, Fukushima M, Kuroda R. A phase I/IIa clinical trial of third-generation autologous chondrocyte implantation (IK-01) for focal cartilage injury of the knee. Asia-Pac J Sports Med Arthrosc Rehabil Technol. 2022;28:6-12.

(22) Hiranaka Y, Muratsu H, Tsubosaka M, Matsumoto T, Maruo A, Miya H, Kuroda R, Matsushita T. Influence of posterior tibial slope on sagittal knee alignment with comparing contralateral knees of anterior cruciate ligament injured patients to healthy knees. Sci Rep. 2022 Aug 18;12(1):14071.

(23) Kamada K, Matsushita T, Nagai K, Hoshino Y, Araki D, Kanzaki N, Matsumoto T, Niikura T, Kuroda R. Risk factors of residual pivot-shift after anatomic double-bundle anterior cruciate ligament reconstruction. Arch Orthop Trauma Surg. 2022 Apr 1. doi: 10.1007/s00402-022-04428-y. Epub ahead of print.

(24) Hong CK, Hoshino Y, Watanabe S, Nagai K, Matsushita T, Su WR, Kuroda R. The coronal lateral collateral ligament sign in the anterior cruciate ligament-injured knees was observed regardless of the knee laxity based on the quantitative measurements. Knee Surg Sports Traumatol Arthrosc. 2022;30(10):3508-3514.

(25) Zakharia A, Lameire DL, Abdel Khalik H, Kay J, Uddandam A, Nagai K, Hoshino Y, de SA D. Quadriceps tendon autograft for pediatric anterior cruciate ligament reconstruction results in promising postoperative function and rates of return to sports: A systematic review. Knee Surg Sports Traumatol Arthrosc. 2022;30(11):3659-3672.

(26) Ueda Y, Matsushita T, Shibata Y, Takiguchi K, Ono K, Kida A, Ono R, Nagai K, Hoshino Y, Matsumoto T, Sakai Y, Kuroda R. Association Between Meeting Return-to-Sport Criteria and Psychological Readiness to Return to Sport After Anterior Cruciate Ligament Reconstruction. Orthop J Sports Med. 2022;10(5):23259671221093985.

(27) Mori A, Matsushita T, Miyaji N, Nagai K, Araki D, Kanzaki N, Matsumoto T, Niikura T, Hoshino Y, Kuroda R. Analysis of popliteal artery location for high tibial and distal tuberosity osteotomy using contrast-enhanced computed tomography. Knee Surg Relat Res. 2022;34(1):25.

(28) Matsushita T, Mori A, Watanabe S, Kataoka K, Oka S, Nishida K, Nagai K, Matsumoto T, Hoshino Y, Kuroda R. Analysis of bone union after medial closing wedge distal femoral osteotomy using a new radiographic scoring system. Arch Orthop Trauma Surg. 2022;142(9):2303-2312.

(29) Nakanishi Y, Nagai K, Kay J, Zakharia A, Nukuto K, Hoshino Y, Matsushita T, Kuroda R, de SA D. The Incidence of Tibial Tunnel Coalition is Higher Than Femoral Tunnel Coalition in Double-Bundle Anterior Cruciate Ligament Reconstruction Using Hamstring Autografts: A Systematic Review. Orthop Traumatol Surg Res. 2022;108(8):103407.

(30) Eliya Y, Qureshi AR, Kay J, Nagai K, Hoshino Y, de Sa D. Anatomical double-bundle anterior cruciate ligament reconstruction moderately improved tegner scores over the long-term: a systematic review and meta-analysis of randomized controlled trials. Knee Surg Sports Traumatol Arthrosc. 2022 Jul 15. doi: 10.1007/s00167-022-07046-8. Epub ahead of print.

(31) Nukuto K, Matsushita T, Kamada K, Nishida K, Nagai K, Kanzaki N, Hoshino Y, Matsumoto T, Niikura T, Kuroda R. Development and analysis of mouse medial meniscus posterior root tear model. Calcif Tissue Int. 2022 Oct 15. doi: 10.1007/s00223-022-01028-1. Epub ahead of print. PMID: 36242608.

(32) Singh H, Glassman I, Sheean A, Hoshino Y, Nagai K, de SA D. Less than 1% risk of donor-site quadriceps tendon rupture post-ACL reconstruction with quadriceps tendon autograft: a systematic review. Knee Surg Sports Traumatol Arthrosc. 2022 Oct 18. doi: 10.1007/s00167-022-07175-0. Epub ahead of print.

(33) Kataoka K, Nagai K, Hoshino Y, Shimabukuro M, Nishida K, Kanzaki N, Matsushita T, Kuroda R. Steeper lateral posterior tibial slope and greater lateral-medial slope asymmetry correlate with greater preoperative pivot-shift in anterior cruciate ligament injury. J Exp Orthop 2022;9(1):117.

(34) Mir B, Vivekanantha P, Dhillon S, Cotnareanu O, Cohen D, Nagai K, de SA D. Fear of reinjury following primary anterior cruciate ligament reconstruction: a systematic review. Knee Surg Sports Traumatol Arthrosc. 2022 Dec 23. doi: 10.1007/s00167-022-07296-6. Epub ahead of print. PMID: 36562808.

(35) Araki S, Tsubosaka M, Muratsu H, Inokuchi T, Maruo H, Miya H, Kuroda R, Matsushita T. Evaluation of morphological characteristics for incomplete discoid medial meniscus with an oversized posterior segment. J Orthop Surg Res. 2022 Apr 20;17(1):245.

(36) Gyemi LA, Bednar ED, Sheean AJ, Kuroda R, de Sa D. The quadriceps tendon autograft is an option for primary PCL reconstruction: a systematic review. J ISAKOS. 2022;7(1):27-34.

(37) Matsushita T, Akiyama T, Osano K, Yokoyama Y, Okazaki K. Biomechanical analysis of the role of hinge support fixators on hinge stability in medial closing wedge distal femoral osteotomy. Clin Biomech. 2022;91:105528.

(38) Nishida K, Xu C, Gale T, Anderst W, Fu F. Symmetry and sex differences in knee kinematics and ACL elongation in healthy collegiate athletes during high-impact activities revealed through dynamic biplane radiography. J Orthop Res. 2022;40(1):239-251.

(39) Kataoka K, Hoshino Y, Nagamune K, Nukuto K, Yamamoto T, Yamashita T, Kanzaki N, Kakutani K, Matsushita T, Kuroda R. The quantitative evaluation of anterior drawer test using an electromagnetic measurement system. Sports Biomech. 2022;21(4):550-561

(40) Nishida K, Gale T, Chiba D, Suntaxi F, Lesniak B, Fu F, Anderst W, Musahl V. The effect of lateral extra-articular tenodesis on in vivo cartilage contact in combined anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc. 2022;30(1):61-70.

(41) Kamada K, Nagai K, Nagamune K, Hoshino Y, Nakanishi Y, Araki D, Kanzaki N, Matsushita T, Kuroda R. Direct suturing quadriceps tendon to a continuous loop with a suspensory button provides biomechanically superior fixation in ACL reconstruction. Knee Surg Sports Traumatol Arthrosc. 2021 Nov 22. doi: 10.1007/s00167-021-06805-3. Epub ahead of print.

(42) Yamamoto T, Nagai K, Kanzaki N, Kataoka K, Nukuto K, Hoshino Y, Matsushita T, Kuroda R. Comparison of Clinical Outcomes Between Ceramic-Based Total Ankle Arthroplasty with Ceramic Total Talar Prosthesis and Ceramic-Based Total Ankle Arthroplasty. Foot Ankle Int. 2021 Nov 18:10711007211051353. doi: 10.1177/10711007211051353. Epub ahead of print.

(43) Matsushita T, Akiyama T, Osano K, Yokoyama Y, Okazaki K. Biomechanical analysis of the role of hinge support fixators on hinge stability in medial closing wedge distal femoral osteotomy. Clin Biomech. 2021 Nov 15;91:105528. doi: 10.1016/j.clinbiomech.2021.105528. Epub ahead of print.

(44) Nagai K, Kamada K, Kay J, Hoshino Y, Matsushita T, Kuroda R, de Sa D. Clinical Outcomes After Anterior Cruciate Ligament Reconstruction in Patients With a Concomitant Segond Fracture: A Systematic Review. Am J Sports Med. 2021 Oct 20;3635465211045689. doi: 10.1177/03635465211045689. Epub ahead of print.

(45) Nishida K, Xu C, Gale T, Anderst W, Fu F. Symmetry and sex differences in knee kinematics and ACL elongation in healthy collegiate athletes during high-impact activities revealed through dynamic biplane radiography. J Orthop Res. 2021 Aug 13. doi: 10.1002/jor.25162. Epub ahead of print.

(46) Kataoka K, Hoshino Y, Nagamune K, Nukuto K, Yamamoto T, Yamashita T, Kanzaki N, Kakutani K, Matsushita T, Kuroda R. The quantitative evaluation of anterior drawer test using an electromagnetic measurement system. Sports Biomech. 2021 May 20:1-12. doi: 10.1080/14763141.2021.1918754. Epub ahead of print.

(47) Nishida K, Gale T, Chiba D, Suntaxi F, Lesniak B, Fu F, Anderst W, Musahl V. The effect of lateral extra-articular tenodesis on in vivo cartilage contact in combined anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc. 2021 Feb 12. doi: 10.1007/s00167-021-06480-4. Epub ahead of print.

(48) Yamamoto T, Miyaji N, Kataoka K, Nishida K, Nagai K, Kanzaki N, Hoshino Y, Kuroda R, Matsushita T. Knee Osteoarthritis Progression Is Delayed in Silent Information Regulator 2 Ortholog 1 Knock-in Mice. Int J Mol Sci. 2021;22(19):10685.

(49) Kamada K, Matsushita T, Yamashita T, Matsumoto T, Iwaguro H, Sobajima S, Kuroda R. Attenuation of Knee Osteoarthritis Progression in Mice through Polarization of M2 Macrophages by Intra-Articular Transplantation of Non-Cultured Human Adipose-Derived Regenerative Cells. J Clin Med. 2021;10(19):4309.

(50) Kataoka K, Watanabe S, Nagai K, Kay J, Matsushita T, Kuroda R, de Sa D. Patellofemoral Osteoarthritis Progresses After Medial Open-Wedge High Tibial Osteotomy: A Systematic Review. Arthroscopy. 2021;37(10):3177-3186.

(51) Ueda Y, Matsushita T, Shibata Y, Takiguchi K, Ono K, Kida A, Ono R, Nagai K, Araki D, Hoshino Y, Matsumoto T, Niikura T, Sakai Y, Kuroda R. Satisfaction with playing pre-injury sports 1 year after anterior cruciate ligament reconstruction using a hamstring autograft. Knee. 2021;33:282-289.

(52) Yamamoto T, Nagai K, Araki D, Miyaji N, Nakanishi Y, Hoshino Y, Kanzaki N, Matsumoto T, Niikura T, Kuroda R, Matsushita T. Influence of selected plane on the evaluation of tibial tunnel locations using a three-dimensional bone model in double-bundle anterior cruciate ligament reconstruction. Knee. 2021;29:298-304.

(53) Yamamoto T, Nagai K, Kanzaki N, Nukuto K, Yamashita T, Ibaraki K, Araki D, Hoshino Y, Matsushita T, Kuroda R. Anterior placement of the talar component in total ankle arthroplasty: A risk factor for talar component subsidence. Foot Ankle Surg. 2021;27(3):311-315.

(54) Matsushita T, Watanabe S, Araki D, Nagai K, Hoshino Y, Kanzaki N, Matsumoto T, Niikura T, Kuroda R. Differences in preoperative planning for high-tibial osteotomy between the standing and supine positions. Knee Surg Relat Res. 2021;33(1):8.

(55) Buerba RA, Zaffagnini S, Kuroda R, Musahl V. ACL reconstruction in the professional or elite athlete: state of the art. J ISAKOS. 2021;6(4):226-236.

(56) Chiba D, Gale T, Nishida K, Suntaxi F, Lesniak BP, Fu FH, Anderst W, Musahl V. Lateral Extra-articular Tenodesis Contributes Little to Change In Vivo Kinematics After Anterior Cruciate Ligament Reconstruction: A Randomized Controlled Trial. Am J Sports Med. 2021;49(7):1803-1812.

(57) Sasaki Y, Fujii M, Araki D, Marshall BD, Linde MA, Smolinski P, Fu FH. Effect of Percentage of Femoral Anterior Cruciate Ligament Insertion Site Reconstructed With Hamstring Tendon on Knee Kinematics and Graft Force. Am J Sports Med. 2021;49(5):1279-1285.

(58) Matsui T, Kumai T, Shinohara Y, Kanzaki N, Noguchi K, Tanaka H, Sugimoto T, Yabiku H, Higashiyama I. A false-pouch closure technique with an intact superior peroneal retinaculum for recurrent dislocation of the peroneal tendon. J Exp Orthop. 2021;8(1):22.

(59) Nukuto K, Hoshino Y, Yamamoto T, Miyaji N, Nagai K, Araki D, Kanzaki N, Matsushita T, Kuroda R. Anatomic double-bundle anterior cruciate ligament reconstruction could not achieve sufficient control of pivot-shift when accompanying tibial tunnel coalition. Knee Surg Sports Traumatol Arthrosc. 2021;29(11):3743-3750.

(60) Yamamoto T, Nagai K, Kanzaki N, Nukuto K, Yamashita T, Ibaraki K, Araki D, Hoshino Y, Matsushita T, Kuroda R. Anterior placement of the talar component in total ankle arthroplasty: A risk factor for talar component subsidence. Foot Ankle Surg. 2021;27(3):311-315.

(61) Miyaji N, Araki D, Hoshino Y, Kanzaki N, Nagai K, Matsumoto T, Niikura T, Kuroda R, Matsushita T. The sagittal cutting plane affects evaluation of the femoral bone tunnel position on three-dimensional computed tomography after anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc. 2021;29(2):398-404.

(62) Miyaji N, Nishida K, Tanaka T, Araki D, Kanzaki N, Hoshino Y, Kuroda R, Matsushita T. Inhibition of Knee Osteoarthritis Progression in Mice by Administering SRT2014, an Activator of Silent Information Regulator 2 Ortholog 1. Cartilage. 2020:1947603519900795. doi: 10.1177/1947603519900795. Epub ahead of print.

(63) Byrne KJ, Rothrauff BB, Nagai K, Onishi K, Fu FH. Two-fragment Segond fracture validates historical descriptions of independent soft tissue attachments. Knee Surg Sports Traumatol Arthrosc 2021 Epub ahead of print. doi: 10.1007/s00167-021-06515-w.

(64) Longo UG, Nagai K, Salvatore G, Cella E, Candela V, Cappelli F, Ciccozzi M, Denaro V. Epidemiology of anterior cruciate ligament reconstruction surgery in Italy: a 15-year nationwide registry study. J Clin Med 2021;10(2):223.

(65) Nakanishi Y, Hoshino Y, Nagamune K, Yamamoto T, Nagai K, Araki D, Kanzaki N, Matsushita T, Kuroda R. Radial Meniscal Tears Are Best Repaired by a Modified "Cross" Tie-Grip Suture Based on a Biomechanical Comparison of 4 Repair Techniques in a Porcine Model. Orthop J Sports Med. 2020;8(7):2325967120935810.

(66) Yamamoto T, Hoshino Y, Kanzaki N, Nukuto K, Yamashita T, Ibaraki K, Nagamune K, Nagai K, Araki D, Matsushita T, Kuroda R. Plantar pressure sensors indicate women to have a significantly higher peak pressure on the hallux, toes, forefoot, and medial of the foot compared to men. J Foot Ankle Res. 2020;13(1):40.

(67) Hoshino Y, Hiroshima Y, Miyaji N, Nagai K, Araki D, Kanzaki N, Kakutani K, Matsushita T, Kuroda R. Unrepaired lateral meniscus tears lead to remaining pivot-shift in ACL-reconstructed knees. Knee Surg Sports Traumatol Arthrosc. 2020;28(11):3504-3510.

(68) Hiroshima Y, Hoshino Y, Miyaji N, Tanaka T, Araki D, Kanzaki N, Matsushita T, Kuroda R. No difference in postoperative rotational laxity after ACL reconstruction in patients with and without anterolateral capsule injury: quantitative evaluation of the pivot-shift test at 1-year follow-up. Knee Surg Sports Traumatol Arthrosc. 2020;28(2):489-494.

(69) Nakanishi Y, Matsushita T, Nagai K, Araki D, Kanzaki N, Hoshino Y, Matsumoto T, Niikura T, Kuroda R. Greater knee joint laxity remains in teenagers after anatomical double-bundle anterior cruciate ligament reconstruction compared to young adults. Knee Surg Sports Traumatol Arthrosc. 2020;28(8):2663-2667.

(70) Kanzaki N, Chinzei N, Yamashita T, Kumai T, Kuroda R. A Novel Technique of Arthroscopic Ankle Lateral Ligament Repair Using a Knotless Suture Anchor. Orthop J Sports Med. 2020;8(11):2325967120962079.

(71) Nishida K, Matsushita T, Hoshino Y, Araki D, Matsumoto T, Niikura T, Kuroda R. The Influences of Chronicity and Meniscal Injuries on Pivot Shift in Anterior Cruciate Ligament-Deficient Knees: Quantitative Evaluation Using an Electromagnetic Measurement System. Arthroscopy. 2020;36(5):1398-1406.

(72) Lian J, Diermeier T, Meghpara M, Popchak A, Smith CN, Kuroda R, Zaffagnini S, Samuelsson K, Karlsson J, Irrgang JJ, Musahl V; PIVOT Study Group. Rotatory Knee Laxity Exists on a Continuum in Anterior Cruciate Ligament Injury. J Bone Joint Surg Am. 2020;102(3):213-220.

(73) Diermeier T, Meredith SJ, Irrgang JJ, Zaffagnini S, Kuroda R, Hochino Y, Samuelsson K, Smith CN, Popchak A, Musahl V; PIVOT Study Group, Sheean A, Burnham JM, Lian J, Smith C, Popchak A, Herbst E, Pfeiffer T, Araujo P, Oostdyk A, Guenther D, Ohashi B, Irrgang JJ, Fu FH, Nagamune K, Kurosaka M, Kuroda R, Hoshino Y, Grassi A, Muccioli GMM, Lopomo N, Signorelli C, Raggi F, Zaffagnini S, Horvath A, Svantesson E, Senorski EH, Sundemo D, Bjoernsson H, Ahlden M, Desai N, Samuelsson K, Karlsson J. Patient-Reported and Quantitative Outcomes of Anatomic Anterior Cruciate Ligament Reconstruction With Hamstring Tendon Autografts. Orthop J Sports Med. 2020;8(7):2325967120926159.

(74) Horvath A, Meredith SJ, Nishida K, Hoshino Y, Musahl V. Objectifying the Pivot Shift Test. Sports Med Arthrosc Rev. 2020;28(2):36-40.

(75) Nagai K, Rothrauff BB, Li RT, Fu FH. Over-the-top ACL reconstruction restores anterior and rotatory knee laxity in skeletally immature individuals and revision settings. Knee Surg Sports Traumatol Arthrosc 2020;28(2):538-43.

(76) Naendrup JH, Pfeiffer TR, Chan C, Nagai K, Novaretti JV, Sheean AJ, Shafizadeh ST, Debski RE, Musahl V. Effect of Meniscal Ramp Lesion Repair on Knee Kinematics, Bony Contact Forces, and In Situ Forces in the Anterior Cruciate Ligament: Response. Am J Sports Med 2020;48(2):NP25-NP7.

(77) Matsushita T, Araki D, Matsumoto T, Niikura T, Kuroda R. Changes in knee extensor strengths before and after medial patellofemoral ligament reconstruction. Phys Sportsmed. 2019;47(2):220-226.

(78) Hoshino Y, Miyaji N, Nishida K, Nishizawa Y, Araki D, Kanzaki N, Kakutani K, Matsushita T, Kuroda R. The concomitant lateral meniscus injury increased the pivot shift in the anterior cruciate ligament-injured knee. Knee Surg Sports Traumatol Arthrosc. 2019;27(2):646-651.

(79) Kanzaki N, Chinzei N, Yamamoto T, Yamashita T, Ibaraki K, Kuroda R. Clinical Outcomes of Total Ankle Arthroplasty With Total Talar Prosthesis. Foot Ankle Int. 2019;40(8):948-954.

(80) Araki D, Matsushita T, Hoshino Y, Nagai K, Nishida K, Koga H, Nakamura T, Katakura M, Muneta T, Kuroda R. The Anterolateral Structure of the Knee Does Not Affect Anterior and Dynamic Rotatory Stability in Anterior Cruciate Ligament Injury: Quantitative Evaluation With the Electromagnetic Measurement System. Am J Sports Med. 2019;47(14):3381-3388.

(81) Nishida K, Matsushita T, Araki D, Sasaki H, Tanaka T, Hoshino Y, Kanzaki N, Matsumoto T, Nagamune K, Niikura T, Kurosaka M, Kuroda R. Analysis of anterior tibial subluxation to the femur at maximum extension in anterior cruciate ligament-deficient knees. J Orthop Surg (Hong Kong). 2019;27(1):2309499019833606.

(82) Tanaka T, Matsushita T, Miyaji N, Ibaraki K, Nishida K, Oka S, Araki D, Kanzaki N, Hoshino Y, Matsumoto T, Kuroda R. Deterioration of patellofemoral cartilage status after medial open-wedge high tibial osteotomy. Knee Surg Sports Traumatol Arthrosc. 2019;27(4):1347-1354.

(83) Tanaka T, Matsushita T, Nishida K, Takayama K, Nagai K, Araki D, Matsumoto T, Tabata Y, Kuroda R. Attenuation of osteoarthritis progression in mice following intra-articular administration of simvastatin-conjugated gelatin hydrogel. J Tissue Eng Regen Med. 2019;13(3):423-432.

(84) Miyaji N, Hoshino Y, Tanaka T, Nishida K, Araki D, Kanzaki N, Matsushita T, Kuroda R. MRI-determined anterolateral capsule injury did not affect the pivot-shift in anterior cruciate ligament-injured knees. Knee Surg Sports Traumatol Arthrosc. 2019;27(11):3426-3431.

(85) Ueda Y, Matsushita T, Shibata Y, Takiguchi K, Kida A, Araki D, Kanzaki N, Hoshino Y, Ono R, Sakai Y, Kuroda R. Longitudinal Quadriceps Strength Recovery After Anterior Cruciate Ligament Reconstruction With Hamstring Autograft: Patients Stratified by Preoperative Quadriceps Strength Deficit. J Sport Rehabil. 2019;16:1-20.

(86) Shibata Y, Matsushita T, Araki D, Kida A, Takiguchi K, Ueda Y, Ono K, Matsumoto T, Niikura T, Sakai Y, Kuroda R. Prediction of quadriceps strength recovery after anterior cruciate ligament reconstruction with a hamstring autograft: Decision tree analysis. J Orthop Sci. 2019;24(2):301-305.

(87) Katakura M, Koga H, Nakamura T, Araki D, Nagai K, Nishida K, Kuroda R, Muneta T.　Biomechanical Effects of Additional Anterolateral Structure Reconstruction with Different Femoral Attachment Sites on Anterior Cruciate Ligament Reconstruction. Am J Sports Med 2019;47(14):3373-3380.

(88) Naendrup JH, Pfeiffer TR, Chan C, Nagai K, Novaretti JV, Sheean AJ, Shafizadeh ST, Debski RE, Musahl V. Effect of Meniscal Ramp Lesion Repair on Knee Kinematics, Bony Contact Forces, and In Situ Forces in the Anterior Cruciate Ligament. Am J Sports Med 2019;47(13):3195-3202.

(89) Takenaga T, Yoshida M, Albers M, Nagai K, Nakamura T, Fu FH, Onishi K. Preoperative sonographic measurement can accurately predict quadrupled hamstring tendon graft diameter for ACL reconstruction. Knee Surg Sports Traumatol Arthrosc 2019;27(3):797-804.

(90) Nagai K, Yang S, Fu FH, Anderst W. Unloader knee brace increases medial compartment joint space during gait in knee osteoarthritis patients. Knee Surg Sports Traumatol Arthrosc 2019;27(7):2354-60.

(91) Nagai K, Gale T, Chiba D, Su F, Fu FH, Anderst W. The Complex Relationship Between In Vivo ACL Elongation and Knee Kinematics During Walking and Running. J Orthop Res 2019;37(9):1920-1928.
英文著書（2019年以降）
(1) Nagai K, Kuroda R, Zaffagnini S, Núñez M. Patellofemoral Instability in the Adult Female with Recurrent Instability, Chondrosis of Patella and Trochlea. In: Koh JL, Kuroda R, Espregueira-Mendes J, Gobbi A, eds. The Patellofemoral Joint. Springer, Cham.; 2022:137-147.

(2) Hoshino Y, Barnechea A. How to Assess Patient’s Outcome?. In: Musahl V, Karlsson J, Hirschmann MT, et al., eds. Basic Methods Handbook for Clinical Orthopaedic Research: Springer, Berlin, Heidelberg; 2019:83-88.

(3) Patel NK, Yeung M, Nagai K, Musahl V. How to Review a Clinical Research Paper? In: Musahl V, Karlsson J, Hirschmann MT, et al., eds. Basic Methods Handbook for Clinical Orthopaedic Research: Springer, Berlin, Heidelberg; 2019:255-262.