研究・業績 研究・業績

研究・業績

  • 下肢人工関節・関節機能再建/研究

  • 業績
下肢人工関節・関節機能再建グループ
▲下肢人工関節・関節機能再建グループ
【臨床研究】
(1) 膝関節
末期変形性膝関節症に対し、人工膝関節全置換術あるいは単顆型人工膝関節置換術を行っています。良好な術後成績を得るためには、正確な骨切り・コンポーネントの設置および適切な軟部組織バランスの獲得が重要とされています。正確な骨切り・コンポーネントの設置に関しては、Navigation systemを導入・3次元運動を容易に計測できるように独自に改良し、また3次元術前計画ソフトウェアを導入し、その正確性を向上させています。適切な軟部組織バランスの獲得に関しては、独自のtensorを開発し、術中の軟部バランスを評価・調整しています。このtensorは大腿骨コンポーネントを装着し、膝伸展機構を修復し、術後膝を再現した状態で軟部組織バランスを評価できるtensorであり、国内外で高い評価を受けています。現在ではこのtensor systemとnavigation systemを同時に併用することで、正確な骨切り・コンポーネントの設置および適切な軟部組織バランスの獲得が同時に得られるようになり、さらに3次元運動と術後成績、また術中のパラメータとの関係と評価することが可能となっております。これまで、我々は人工膝関節全置換術における手術中の靭帯バランスが術後の靭帯バランスや関節可動域と関係すること、Navigation systemの臨床成績、術後の満足度、術後感染の原因や治療成績などを報告してまいりました。単顆型人工膝関節置換術においても独自に開発したtensorにて靭帯バランスを評価し、術後の臨床成績との関係を研究しております。また、日本人の下肢アライメントの大規模調査を行い、年齢による変化や変形性膝関節症による変化など日本人の特徴を報告しております。これらの研究成果をふまえて、人工膝関節置換術を受けられる患者さまの術後成績の向上、満足度のさらなる向上を目指しています。
(2) 股関節
変形性股関節症に対する人工股関節全置換術は優れた除痛効果など安定した治療成績が期待されます。またインプラントデザインや慴動面の改良、材質の向上など長期成績についても良好な結果が期待されております。しかしながら、インプラントデザインによる固着部位の相違によりインプラント周囲の骨密度が低下する問題点が指摘されております。そこで人工股関節全置換術後から大腿骨を中心とした骨密度を測定し、より生理的な荷重伝達を可能とするインプラントの選択等、治療成績向上に向けて研究を行っています。

寛骨臼形成不全に対する骨切り手術(寛骨臼回転骨切り術)では、Cerved Periacetabular Osteotomy (CPO) を採用して治療に当たっております。この術式では皮切が9cmであり股関節外転筋力への影響が極めて低いことから低侵襲手術であると考えられる一方、骨切り線や寛骨臼の回転方向・量を術者の経験などに頼ることが問題点でした。そこで現在、3Dシュミレーションソフトならびにナビゲーションを併用して手術を行っております。適切な骨切り線や荷重環境の獲得、さらに手術成績の標準化を目指しています。
【基礎研究】
(1) Biomechanics
人工膝関節においては、Navigation system、Tensor systemを併用した手術、2D-3D image matching techniqueを用いて三次元解析ソフトを用いて人工膝関節の3次元動作解析を行い、同時に術前パラメータ・術中操作・術中パラメ-タ・術後成績の関連を解析し、より生理的に動く、そしてより曲がる膝を目指して研究しています。また、東京女子医科大学 先端生命医科学研究所(http://www.twmu.ac.jp/ABMES/FATS/)と共同研究を行っており、軟部組織バランス測定ロボットテンサーを開発中です。
(2) Biology 変形性股関節症における軟骨損傷の病態解明
変形性関節症に対する手術的治療として人工関節置換術は非常に良好な成績を収め、確立されたものとなっていますが、有効な保存的治療(内服、遺伝子治療等)は確立されておりません。よって我々は軟骨変性に対し、病態の解明ならびに薬物ならびに遺伝子治療を開発することを研究の目的としております。 変形性関節症の発症にはさまざまな遺伝子が関与しており、我々はその中で癌抑制遺伝子であるp53さらにp53関連分子のp38 MAPK, p53R2 が関与するという非常に興味深い新しい知見を得ました。その後p53に関連してp21, PTENなどの分子に着目し変形性関節症の病態解明および進行予防を含めた軟骨治療戦略への応用につなげていきたいと思っております。

これらの研究成果を日本整形外科学会、日本整形外科基礎学術集会、日本人工関節学会、日本関節鏡・膝・スポーツ整形外科学会(JOSKAS)、日本股関節学会、日本臨床バイオメカニクス学会、日本CAOS (Computer Assisted Orthopaedic Surgery)研究会、日本軟骨代謝学会、アメリカ整形外科学会(AAOS)、国際人工関節技術学会(ISTA)、International Congress for Joint Reconstruction (ICJR)、Computer Assisted Orthopaedic Surgery (CAOS) International、国際関節鏡・膝・スポーツ整形外科学会(ISAKOS)、アメリカ整形外科基礎学会(ORS)等で報告し、新たな人工関節の開発を目指しています。

  • 下肢人工関節・関節機能再建/業績

  • 研究
英文原著論文(2019年以降)
(1) Matsumoto T, Nakano N, Ishida K, Takashima Y, Maeda T, Kuroda Y, Hayashi S, Matsushita T, Niikura T, Muratsu H, Kuroda R. The effect of prosthesis type on intraoperative soft tissue balance and clinical outcomes in modified kinematically aligned cruciate-retaining total knee arthroplasty. J Knee Surg. 2023; 36(10):1013-1019.

(2) Matsumoto T, Nakano N, Hayashi S, Takayama K, Maeda T, Ishida K, Kuroda Y, Matsushita T, Niikura T, Muratsu H, Kuroda R. Prosthetic orientation, limb alignment, and soft tissue balance with bi-cruciate stabilized total knee arthroplasty: A comparison between the handheld robot and conventional techniques. Int Orthop. 2023; 47(6):1473-1480.

(3) Matsumoto T, Nakano N, Ishida K, Kuroda Y, Hayashi S, Muratsu H, Kuroda R. Ground kinematically aligned total knee arthroplasty: a new personalized technique which enables a stable knee with deep flexion. Int Orthop. 20233; 47(9):2215–2223.

(4) Matsumoto T, Nakano N, Ishida K, Maeda T, Tachibana S, Kuroda Y, Hayashi S, Matsushita T, Kuroda R. Targeting the neutral hip-to-calcaneus axis in kinematically aligned total knee arthroplasty is feasible with fewer alignment outliers for varus osteoarthritic patients. Knee Surg Sports Traumatol Arthrosc. 2023; 31(9):3880-3888.

(5) Nakano N, Kuroda Y, Tsubosaka M, Kamenaga T, Ishida K, Hayashi S, Matsushita T, Hoshino Y, Kuroda R, Matsumoto T. The influence of patellar height on patellofemoral contact force during total knee arthroplasty. J Joint Surg Res. 2023;1(1):186-191.

(6) Suda Y, Hiranaka T, Kamenaga T, Fujishiro T, Okamoto K, Matsumoto T. Mobile bearing orbit on the tibial component in Oxford unicompartmental knee arthroplasty. Knee. 2023; 42:136-142.

(7) Anjiki K, Matsumoto T, Kuroda Y, Fujita M, Hayashi S, Nakano N, Tsubosaka M, Kamenaga T, Takashima Y, Kikuchi K, Ikuta K, Onoi Y, Tachibana S, Suda Y, Wada K, Matsushita T, Kuroda R. Heterogeneous Cells as well as Adipose-Derived Stromal Cells in Stromal Vascular Fraction Contribute to Enhance Anabolic and Inhibit Catabolic Factors in Osteoarthritis. Stem Cell Rev Rep. 2023; 19(7):2407-2419.

(8) Anjiki K, Hayashi S, Fujishiro T, Hiranaka T, Kuroda R, Matsumoto T. Rectangular tapered short stem excellently preserves proximal bone mineral density preservation than tapered wedge short stem. Acta Orthop Belg. 2023; 89(3):491-497.

(9) Onoi Y, Matsumoto T, Sobajima S, Tsubosaka M, Hayashi S, Matsushita T, Iwaguro H, Kuroda R. Clinical use of autologous adipose-derived stromal vascular fraction cell injections for hip osteoarthritis. Regen Ther. 2023; 24:94-102.

(10) Tsubosaka M, Muratsu H, Nakano N, Kamenaga T, Kuroda Y, Inokuchi T, Miya H, Kuroda R, Matsumoto T. Knee Stability following Posterior-Stabilized Total Knee Arthroplasty: Comparison of Medial Preserving Gap Technique and Measured Resection Technique. J Knee Surg. 2023; 36(1):95-104.

(11) Hayashi S, Kuroda Y, Nakano N, Matsumoto T, Tachibana S, Kuroda R. Comparison study of periprosthetic bone remodeling between simultaneous bilateral total hip arthroplasty and unilateral total hip arthroplasty: a matched cohort study. Int Orthop.2023; 47:2767-2772.

(12) Fujita M, Hayashi S, Kuroda Y, Nakano N, Maeda T, Matsushita T, Matsumoto T, Kuroda R. Accuracy comparison of cup positioning during total hip arthroplasty using Hip Align and AR-Hip in the supine position. Arch Orthop Trauma Surg. 2023; 143:7229-7235.

(13) Takashima Y, Nakano N, Ishida K, Kamenaga T, Tsubosaka M, Kuroda Y, Hayashi S, Kuroda R, Matsumoto T. Effects of Femoral Component Design on the Deepest Point Position of the Trochlear Grove in Kinematically Aligned Total Knee Arthroplasty: A Comparison of Four Prothesis Designs. J Knee Surg. 2023; 36:1316-1322.

(14) Fujita M, Hayashi S, Hashimoto S, Kuroda Y, Kuroda R, Matsumoto T. The influence of stem alignment on the bone mineral density around the Polarstem following total hip arthroplasty. Arch Orthop Trauma Surg. 2023; 143:3621-3627.

(15) Hayashi S, Kuroda Y, Nakano N, Matsumoto T, Kamenaga T, Maeda T, Kuroda R. Comparing the accuracy of three-dimensional mini-optical portable navigation and accelerometer-based portable navigation system for acetabular cup placement during total hip arthroplasty. Arch Orthop Trauma Surg. 2023; 143:3759-3766.

(16) Fujita M, Matsumoto T, Sobajima S, Tsubosaka M, Matsushita T, Iwaguro H, Kuroda R. Clinical and Radiological Comparison of Single and Double Intra-articular Injection of Adipose-Derived Stromal Vascular Fraction for Knee Osteoarthritis. Cell Transplant. 2023; 32:9636897231190175.

(17) Kuroda Y, Hashimoto S, Hayashi S, Nakano N, Fujishiro T, Hiranaka T, Kuroda R, Matsumoto T. Fully hydroxyapatite-coated compaction broached and triple-tapered stem may reduce the risk of stress shielding after primary total hip arthroplasty. Arch Orthop Trauma Surg. 2022;142(12):4087-4093.

(18) Kuroda Y, Hashimoto S, Saito M, Matsumoto T, Nakano N, Kuroda R, Hayashi S. Femoro-Epiphyseal Acetabular Roof (FEAR) Index and Anterior Acetabular Coverage Correlate With Labral Length in Developmental Dysplasia of the Hip. Arthroscopy. 2022;38(2):374-381.

(19) Takashima Y, Hayashi S, Maeda T, Fukuda K, Onoi Y, Tachibana S, Ikuta K, Anjiki K, Fujita M, Kikuchi K, Kamenaga T, Kuroda R, Matsubara T. Histopathological changes of synovial tissue in rheumatoid arthritis patients treated with TNF-α inhibitors or IL-6 inhibitors. Clinical and Experimental Rheumatology. 2022;40(11):2060-2070.

(20) Onoi Y, Hiranaka T, Hida Y, Fujishiro T, Okamoto K, Matsumoto T, Kuroda R. Second-look Arthroscopic Findings and Clinical Outcomes after Adipose-derived Regenerative Cell Injection in Knee Osteoarthritis. Clin Orthop Surg. 2022;14(3):377-385.

(21) Kikuchi K, Haneda M, Hayashi S, Maeda T, Nakano N, Kuroda Y, Tsubosaka M, Kamenaga T, Fujita M, Ikuta K, Anjiki K, Tachibana S, Onoi Y, Matsumoto T, Kuroda R. P21 deficiency exhibits delayed endochondral ossification during fracture healing. Bone. 2022 ;165:116572

(22) Suda Y, Hiranaka T, Kamenaga T, Koide M, Fujishiro T, Okamoto K, Matsumoto T. Varus placement of the tibial component of Oxford unicompartmental knee arthroplasty decreases the risk of postoperative tibial fracture. Bone Joint J. 2022;(10):1118-1125.

(23) Fujita M, Matsumoto T, Hayashi S, Hashimoto S, Nakano N, Maeda T, Kuroda Y, Takashima Y, Kikuchi K, Anjiki K, Ikuta K, Onoi Y, Tachibana S, Matsushita T, Iwaguro H, Sobajima S, Hiranaka T, Kuroda R. Paracrine effect of the stromal vascular fraction containing M2 macrophages on human chondrocytes through the Smad2/3 signaling pathway. J Cell Physiol. 2022;237(9):3627-3639.

(24) Fujita M, Hayashi S, Kamenaga T, Fujishiro T, Matsumoto T, Kuroda R. Ligament preserving total hip arthroplasty prevents different leg length and femoral offset. Acta Ortop Bras. 2022;6;30(spe1): e242758.

(25) Fujita M, Matsumoto T, Nakano N, Ishida K, Kuroda Y, Maeda T, Hayashi S, Kuroda R. Rotational mismatch between femoral and tibial components should be avoided in JOURNEY II bi-cruciate stabilized total knee arthroplasty. Knee. 2022;38: 69-75.

(26) Anjiki K, Kamenaga T, Hayashi S, Hashimoto S, Kuroda Y, Nakano N, Fujishiro T, Hiranaka T, Niikura T, Kuroda R, Matsumoto T. Effectiveness of an accelerometer-based portable navigation for intraoperative adjustment of leg length discrepancy in total hip arthroplasty in the supine position. J Orthop Sci. 2022 ;27(1):169-175.

(27) Kamenaga T, Hiranaka T, Nakano N, Hayashi S, Fujishiro T, Okamoto K, Kuroda R, Matsumoto T. Short distance from the keel to the posterior tibial cortex is associated with fracture after cementless Oxford UKA in Asian patients. Knee Surg Sports Traumatol Arthrosc. 2022;30(4):1220-1230.

(28) Kamenaga T, Hiranaka T, Hida Y, Nakano N, Kuroda Y, Tsubosaka M, Hayashi S, Kuroda R, Matsumoto T. Lateral osteoarthritis progression is associated with a postoperative residual tibiofemoral subluxation in Oxford UKA. Knee Surg Sports Traumatol Arthrosc. 2022 ;30(9):3236-3243.

(29) Kamenaga T, Nakano N, Ishida K, Tsubosaka M, Kuroda Y, Hayashi S, Matsushita T, Niikura T, Kuroda R, Matsumoto T. Preoperative uncorrectable tibiofemoral subluxation can worsen clinical outcomes after fixed-bearing unicompartmental knee arthroplasty: a retrospective analysis. Arch Orthop Trauma Surg. 2022;142(10):2865-2874.

(30) Tachibana S, Muratsu H, Tsubosaka M, Maruo A, Miya H, Kuroda R, Matsumoto T. Evaluation of consistency of patient-satisfaction score in the 2011 Knee Society Score to other patient-reported outcome measures. J Orthop Sci. 2022 ;27(3):652-657.

(31) Hayashi S, Hashimoto S, Kuroda Y, Matsumoto T, Kamenaga T, Kuroda R. Combination of Anterior Acetabular Coverage and Femoral Head Shape Predicts Femoroacetabular Impingement After Periacetabular Osteotomy. J Arthroplasty. 2022;37(2):219-225.

(32) Hayashi S, Kuroda Y, Nakano N, Matsumoto T, Kamenaga T, Maeda T, Niikura T, Kuroda R. Peri-prosthetic bone remodeling of hydroxyapatite-coated compaction short stem was not affected by stem alignment. J Orthop Surg Res. 2022;3;17(1):131.

(33) Hayashi S, Hashimoto S, Kuroda Y, Nakano N, Matsumoto T, Kamenaga T, Kuroda R. Anterior acetabular coverage and femoral head-neck measurements predict postoperative anterior impingement: A simulation study. J Orthop Res. 2022 ;40(10):2440-2447.

(34) Hayashi S, Hashimoto S, Kuroda Y, Nakano N, Matsumoto T, Kamenaga T, Niikura T, Kuroda R. Hydroxyapatite-coated compaction short stem represents a characteristic pattern of peri-prosthetic bone remodelling after total hip arthroplasty. Arch Orthop Trauma Surg. 2022;142(10):2903-2910.

(35) Hayashi S, Kuroda Y, Nakano N, Matsumoto T, Kamenaga T, Maeda T, Kuroda RA combination of acetabular coverage and femoral head–neck measurements can help diagnose femoroacetabular impingement. Journal of Hip Preservation Surgery, 2022. 1:1-7

(36) Hayashi S, Matsubara T, Fukuda K, Maeda T, Funahashi K, Hashimoto M, Takashima Y, Kikuchi K, Fujita M, Matsumoto T, Kuroda. A genome-wide association study identifying single nucleotide polymorphisms in the PPFIBP2 gene was predictive for interstitial lung disease in rheumatoid arthritis patients..Rheumatol Adv Pract. 2022 Oct 29;6(3):rkac088

(37) Hayashi S, Matsubara T, Maeda T, Fukuda K, Funahashi K, Hashimoto M, Tsumiyama K, Kamenaga T, Takashima Y, Matsumoto T, Tachibana S, Kuroda R.Comparison of the inhibitory effect of tocilizumab and etanercept on the progression of joint erosion in rheumatoid arthritis treatment. Sci Rep. 2022 ;20;12(1):17524.

(38) Matsumoto T, Takashima Y, Takayama K, Ishida K, Nakano N, Kuroda Y, Tsubosaka M, Kamenaga T, Matsushita T, Niikura T, Hayashi S, Kuroda R. Comparison between single and multi-radius prostheses used in modified kinematically aligned cruciate-retaining total knee arthroplasty. J Knee Surg. 2022, 35(9): 1004-1009

(39) Kuroda Y, Young M, Shoman H, Punnoose A, Norrish AR, Khanduja V. Advanced rehabilitation technology in orthopaedics-a narrative review. Int Orthop. 2021;45(8):1933-1940.

(40) Kuroda Y, Hashimoto S, Saito M, Hayashi S, Nakano N, Matsushita T, Niikura T, Kuroda R, Matsumoto T. Obesity is associated with less favorable outcomes following hip arthroscopic surgery: a systematic review and meta-analysis. Knee Surg Sports Traumatol Arthrosc. 2021;29(5):1483-1493.

(41) Kuroda Y, Takayama K, Ishida K, Hayashi S, Hashimoto S, Tsubosaka M, Kamenaga T, Matsushita T, Niikura T, Kuroda R, Matsumoto T. Radiographic Comparison of the Mechanical Axis Including Calcaneus to the Conventional Mechanical Axis in Medial Unicompartmental Knee Arthroplasty. J Knee Surg. 2021;34(9):930-935.

(42) Nakano N, Kuroda Y, Maeda T, Takayama K, Hashimoto S, Ishida K, Hayashi S, Hoshino Y, Matsushita T, Niikura T, Kuroda R, Matsumoto T. Modern Femoral Component Design in Total Knee Arthroplasty Shows a Lower Patellar Contact Force During Knee Flexion Compared With Its Predecessor. Knee. 2021;30:1-8.

(43) Nakano N, Takayama K, Kuroda Y, Maeda T, Hashimoto S, Ishida K, Hayashi S, Hoshino Y, Matsushita T, Niikura T, Kuroda R, Matsumoto T. Preoperative Varus Deformity of the Knee Affects the Intraoperative Joint Gap in Unicompartmental Knee Arthroplasty. Knee. 2021;32:90-96.

(44) Nakano N, Kubo S, Sato Y, Takayama K, Mizuno K, Kuroda R, Matsumoto T. Knee Flexion Angle Following Total Knee Arthroplasty Relates to a Preoperative Range of Motion of the Hip. Indian J Orthop. 2021;55(4):948-952.

(45) Nakano N, Mizuno K, Takayama K, Hayashi S, Kuroda R, Matsumoto T. Outcomes of Total Knee Replacement with the Use of a NexGen MIS Tibial Component (Mini-keel): A Systematic Review. Acta Orthop Belg. 2021;87:1-10.

(46) Fujita M, Hiranaka T, Brang Mai, Kamenaga T, Tsubosaka M, Takayama K, Kuroda R, Matsumoto T. External rotation of the tibial component should be avoided in lateral unicompartmental knee arthroplasty. Knee. 2021; 30: 70-77.

(47) Takashima Y, Matsumoto T, Takayama K, Nakano N, Kuroda Y, Tsubosaka M, Kamenaga T, Kikuchi K, Fujita M, Ikuta K, Anjiki K, Hayashi S, Hashimoto S, Maeda T, Inokuchi T, Toda M, Chin T, Kuroda R. Comparison of Clinical and Biomechanical Outcomes between the Kinematic and Mechanical Alignment Methods in Total Knee Arthroplasty: Protocol for a Multicenter Randomized Controlled Trial. Contemp Clin Trials Commun. 2021;22:100775.

(48) Takashima Y, Hayashi S, Fukuda K, Maeda T, Tsubosaka M, Kamenaga T, Kikuchi K, Fujita M, Kuroda Y, Hashimoto S, Nakano N, Matsumoto T, Kuroda R. Susceptibility of cyclin-dependent kinase inhibitor 1-deficient mice to rheumatoid arthritis arising from interleukin-1β-induced inflammation. Scientific Reports. 2021;11(1):12516.

(49) Tsubosaka M, Ishida K, Kodato K, Shibanuma N, Hayashi S, Kurosaka M, Kuroda R, Matsumoto T. Mid-flexion stability in the anteroposterior plane is achieved with a medial congruent insert in cruciate-retaining total knee arthroplasty for varus osteoarthritis. Knee Surg Sports Traumatol Arthrosc. 2021;29(2):467-473.

(50) Tsubosaka M, Kamenaga T, Kuroda Y, Takayama K, Hashimoto S, Ishida K, Hayashi S, Kuroda R, Matsumoto T. Accelerometer-Based Portable Navigation System Is Useful for Tibial Bone Cutting in Modified Kinematically Aligned Total Knee Arthroplasty. J Knee Surg. 2021;34(8):870-876.

(51) Tsubosaka M, Maruyama M, Huang EE, Zhang N, Utsunomiya T, Gao Q, Shen H, Li X, Kushioka J, Hirata H, Yao Z, Yang YP, Goodman SB. Effect on Osteogenic Differentiation of Genetically Modified IL4 or PDGF-BB Over-Expressing and IL4-PDGF-BB Co-Over-Expressing Bone Marrow-Derived Mesenchymal Stromal Cells In Vitro. Bioengineering (Basel). 2021;8(11):165.

(52) Kamenaga T, Nakano N, Takayama K, Tsubosaka M, Takashima Y, Kikuchi K, Fujita M, Kuroda Y, Hashimoto S, Hayashi S, Niikura T, Kuroda R, Matsumoto T. Comparison of plantar pressure distribution during walking and lower limb alignment between modified kinematically and mechanically aligned total knee arthroplasty. J Biomech. 2021;120:110379.

(53) Kamenaga T, Kuroda Y, Nagai K, Tsubosaka M, Takashima Y, Kikuchi K, Fujita M, Ikuta K, Anjiki K, Maeda T, Nakano N, Takayama K, Hashimoto S, Hayashi S, Matsushita T, Niikura T, Kuroda R, Matsumoto T. Cryopreserved human adipose-derived stromal vascular fraction maintains fracture healing potential via angiogenesis and osteogenesis in an immunodeficient rat model. Stem Cell Res Ther. 2021;12(1):110.

(54) Hayashi S, Hashimoto S, Kuroda Y, Nakano N, Matsumoto T, Ishida K, Shibanuma N, Kuroda R. Robotic-arm assisted THA can achieve precise cup positioning in developmental dysplasia of the hip : a case control study. Bone Joint Res 2021;10(10):629-638.

(55) Hayashi S, Hashimoto S, Kuroda Y, Nakano N, Matsumoto T, Ishida K, Shibanuma N, Kamenaga T, Kuroda R. Accuracy of cup position following robot-assisted total hip arthroplasty may be associated with surgical approach and pelvic tilt. Sci Rep. 2021;11(1):7578.

(56) Hayashi S, Matsubara T, Fukuda K, Maeda T, Funahashi K, Hashimoto M, Kamenaga T, Takashima Y, Kuroda R. A genome-wide association study identifying the SNPs predictive of rapid joint destruction in patients with rheumatoid arthritis. Biomed Rep. 2021;14(3):31

(57) Ichise Y, Saegusa J, Tanaka-Natsui S, Naka I, Hayashi S, Kuroda R, Morinobu A.Soluble CD14 Induces Pro-inflammatory Cytokines in Rheumatoid Arthritis Fibroblast-Like Synovial Cells via Toll-Like Receptor 4. Cells. 2020;9(7):1689.

(58) Hayashi S, Hashimoto S, Matsumoto T, Takayama K, Shibanuma N, Ishida K, Niikura T, Nishida K, Kuroda R. Postoperative excessive anterior acetabular coverage is associated with decrease in range of motion after periacetabular osteotomy. Hip Int. 2021;31(5):669-675.

(59) Takeuchi K, Hashimoto S, Matsumoto T, Hayashi S, Takayama K, Kuroda R. Recovery of activity level following total hip arthroplasty in patients less than 60 years of age.Hip Int. 2021;31(5):632-636.

(60) Kuroda Y, Rai A, Saito M, Khanduja V. Anatomical variation of the Psoas Valley: a scoping review. BMC Musculoskelet Disord. 2020;21(1):219.

(61) Kuroda Y, Saito M, Çınar E, Norrish A, Khanduja V. Patient-related Risk Factors Associated with Less Favorable Outcomes following Hip Arthroscopy: A Scoping Review. Bone Joint J. 2020;102-B(7):822-831.

(62) Kuroda Y, Saito M, Sunil Kumar KH, Malviya A, Khanduja V. Hip Arthroscopy and Borderline Developmental Dysplasia of the Hip: A Systematic Review. Arthroscopy. 2020;36(9):2550-2567.

(63) Kuroda Y, Hayashi S, Hashimoto S, Matsumoto T, Takayama K, Kuroda R. Preoperative predictors of health-related quality of life after revision total hip arthroplasty for aseptic loosening. Indian J Orthop. 2020;54(4):463-468.

(64) Kuroda Y, Takayama K, Hayashi S, Hashimoto S, Matsushita T, Niikura T, Kuroda R, Matsumoto T. Varus deformity in the proximal tibia and immediate postoperative varus alignment result in varus progression in limb alignment in the long term after total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc. 2020; 28(10):3287-3293.

(65) Kuroda Y, Takayama K, Hayashi S, Hashimoto S, Tsubosaka M, Kamenaga T, Matsushita T, Niikura T, Kuroda R, Matsumoto T. Mobile-bearing insert reduced patellar contact force at knee flexion during posterior stabilized total knee arthroplasty. Clin Biomech (Bristol, Avon). 2020;76:105022.

(66) Kamenaga T, Takayama K, Ishida K, Hayashi S, Kuroda R, Matsumoto T. Central Implantation of the Femoral Component Relative to the Tibial Insert Improves Clinical Outcomes in Fixed-Bearing Unicompartmental Knee Arthroplasty. J Arthroplasty. 2020;35(11):3108-3116.

(67) Kamenaga T, Hayashi S, Hashimoto S, Fukuda K, Takayama K, Tsubosaka M, Takashima Y, Niikura T, Kuroda R, Matsumoto T. Pelvic morphology medial to the femoral head center predicts anterior coverage and range of motion after curved periacetabular osteotomy. J Orthop Res. 2020;38(9):2031-2039.

(68) Kamenaga T, Hashimoto S, Hayashi S, Takayama K, Niikura T, Kuroda R, Matsumoto T. Larger Acetabular Labrum Is Associated With Hip Dysplasia, Joint Incongruence, and Clinical Symptoms. Arthroscopy. 2020;36(9):2446-2453.

(69) Kamenaga T, Hida Y, Hiranaka T, Tanaka T, Okimura K, Tsubosaka M, Kuroda Y, Nakano N, Hayashi S, Niikura T, Kuroda R, Matsumoto T. Extent of in vivo sagittal bearing movement and its relationship with tibial posterior slopes in Oxford mobile-bearing unicompartmental knee arthroplasty. Clin Biomech (Bristol, Avon). 2020;80:105148.

(70) Kamenaga T, Hayashi S, Hashimoto S, Takayama K, Fujishiro T, Hiranaka T, Kuroda R, Matsumoto T. Intraoperative pelvic movement is associated with the body mass index in patients undergoing total hip arthroplasty in the supine position. J Orthop Sci. 2020;25(3):446-451.

(71) Matsumoto T, Takayama K, Ishida K, Kuroda Y, Tsubosaka M, Muratsu H, Hayashi S, Hashimoto S, Matsushita T, Niikura T, Kuroda R. Intraoperative Soft Tissue Balance/Kinematics and Clinical Evaluation of Modified Kinematically versus Mechanically Aligned Total Knee Arthroplasty. J Knee Surg. 2020;33(8):777-784.

(72) Tsubosaka M, Matsumoto T, Sobajima S, Matsushita T, Iwaguro H, Kuroda R. The influence of adipose-derived stromal vascular fraction cells on the treatment of knee osteoarthritis. BMC Musculoskelet Disord. 2020;21(1):207.

(73) Tsubosaka M, Kihara S, Hayashi S, Nagata J, Kuwahara T, Fujita M, Kikuchi K, Takashima Y, Kamenaga T, Kuroda Y, Takeuchi K, Fukuda K, Takayama K, Hashimoto S, Matsumoto T, Niikura T, Tabata Y, Kuroda R. Gelatin hydrogels with eicosapentaenoic acid can prevent osteoarthritis progression in vivo in a mouse model. J Orthop Res. 2020;38(10):2157-2169.

(74) Tsubosaka M, Muratsu H, Nakano N, Kamenaga T, Kuroda Y, Miya H, Kuroda R, Matsumoto T. Sequential changes in lower extremity function after total knee arthroplasty. J Orthop Surg (Hong Kong). 2020;28(3):2309499020965645.

(75) Takashima Y, Takayama K, Ishida K, Muratsu H, Matsushita T, Niikura T, Kuroda R, Matsumoto T. Comparison of intraoperative soft tissue balance measurement between two tensor systems in total knee arthroplasty. Knee. 2020;27(3):1071-1077.

(76) Hayashi S, Hashimoto S, Takayama K, Matsumoto T, Kamenaga T, Fujishiro T, Hiranaka T, Niikura T, Kuroda R. Evaluation of the accuracy of acetabular cup orientation using the accelerometer-based portable navigation system. J Orthop Sci. 2020;25(4):612-617.

(77) Hayashi S, Hashimoto S, Matsumoto T, Takayama K, Niikura T, Kuroda R. Risk factors of thigh pain following total hip arthroplasty with short, tapered-wedge stem. Int Orthop. 2020;44(12):2553-2558.

(78) Hayashi S, Hashimoto S, Matsumoto T, Takayama K, Kamenaga T, Niikura T, Kuroda R. Preoperative anterior coverage of the medial acetabulum can predict postoperative anterior coverage and range of motion after periacetabular osteotomy: a cohort study. J Orthop Surg Res. 2020;15(1):312.

(79) Hayashi S, Hashimoto S, Matsumoto T, Takayama K, Kamenaga T, Niikura T, Kuroda R. Overcorrection of the acetabular roof angle or anterior center–edge angle may cause decrease of range of motion after curved periacetabular osteotomy. J Hip Preserv Surg. 2020;7(3):583-590..

(80) Nakano N, Shoman H, Khanduja V. Treatment Strategies for Ischiofemoral Impingement - A Systematic Review. Knee Surg Sports Traumatol Arthrosc. 2020; 28(9):2772-2787.

(81) Nakano N, Shoman H, Olavarria F, Matsumoto T, Kuroda R, Khanduja V. Why Are Patients Dissatisfied Following A Total Knee Replacement?: A Systematic Review. Int Orthop. 2020; 44(10):1971-2007.

(82) Suda Y, Takayama K, Ishida K, Hayashi S, Hashimoto S, Niikura T, Matsushita T, Kuroda R, Matsumoto T: Improved implant alignment accuracy with an accelerometer-based portable navigation system in medial unicompartmental knee arthroplasty. Knee Surg Sports Traumatol Arthrosc. 2020;28(9):2917-2923.

(83) Tsubosaka M, Muratsu H, Takayama K, Maruo A, Miya H, Kuroda R, Matsumoto T: Effect of intraoperative soft tissue balance on postoperative recovery of ambulatory and balancing function in posterior-stabilized total knee arthroplasty. J Orthop Sci. 2019, 24:507-513.

(84) Kuroda Y, Takayama K, Ishida K, Hayashi S, Hashimoto S, Nishida K, Matsushita T, Niikura T, Kuroda R, Matsumoto T: Influence of limb alignment and prosthetic orientation on patient-reported clinical outcomes in total knee arthroplasty. J Orthop Sci. 2019, 24:668-673.

(85) Kuroda Y, Matsumoto T, Hayashi S, Hashimoto S, Takayama K, Kirizuki S, Tsubosaka M, Kamenaga T, Takashima Y, Matsushita T, Niikura T, Kuroda R: Intra-articular autologous uncultured adipose-derived stromal cell transplantation inhibited the progression of cartilage degeneration. J Orthop Res. 2019;37:1376-1386.

(86) Kawakami Y, Hambright WS, Takayama K, Mu X, Lu A, Cummins JH, Matsumoto T, Yurube T, Kuroda R, Kurosaka M, Fu FH, Robbins PD, Niedernhofer LJ, Huard J: Rapamycin Rescues Age-Related Changes in Muscle-Derived Stem/Progenitor Cells from Progeroid Mice. Mol Ther Methods Clin Dev. 2019;14:64-76.

(87) Kamenaga T, Takayama K, Ishida K, Muratsu H, Hayashi S, Hashimoto S, Kuroda Y, Tsubosaka M, Takashima Y, Matsushita T, Niikura T, Kuroda R, Matsumoto T: Medial knee stability at flexion increases tibial internal rotation and knee flexion angle after posterior-stabilized total knee arthroplasty. Clin Biomech (Bristol, Avon).2019;68:16-22.

(88) Kamenaga T, Hiranaka T, Takayama K, Tsubosaka M, Kuroda R, Matsumoto T: Adequate Positioning of the Tibial Component Is Key to Avoiding Bearing Impingement in Oxford Unicompartmental Knee Arthroplasty. J Arthroplasty;2019, 34:2606-2613.

(89) Kamenaga T, Hiranaka T, Nakanishi Y, Takayama K, Kuroda R, Matsumoto T: Valgus Subsidence of the Tibial Component Caused by Tibial Component Malpositioning in Cementless Oxford Mobile-Bearing Unicompartmental Knee Arthroplasty. J Arthroplasty. 2019;34:3054-3060.

(90) Kamenaga T, Hayashi S, Hashimoto S, Matsumoto T, Takayama K, Fujishiro T, Hiranaka T, Niikura T, Kuroda R: Accuracy of cup orientation and learning curve of the accelerometer-based portable navigation system for total hip arthroplasty in the supine position. J Orthop Surg (Hong Kong).2019;27:2309499019848871

(91) Hayashi S, Fukuda K, Maeda T, Chinzei N, Kihara S, Miura Y, Sakai Y, Hashimoto S, Matsumoto T, Takayama K, Niikura T, Kuroda R: Denosumab Treatment Improved Health-Related Quality of Life in Osteoporosis: A Prospective Cohort Study. JBMR Plus, 2019, 3:e10191

(92) Fukuda K, Miura Y, Maeda T, Hayashi S, Kuroda R: Expression profiling of genes in rheumatoid fibroblast-like synoviocytes regulated by tumor necrosis factor-like ligand 1A using cDNA microarray analysis. Biomed Rep. 2019;1:1-5.
英文症例報告(2019年以降)
(1) Ikuta K, Matsumoto T, Nakano N, Mukohara S, Hayashi S, Kuroda R. Total knee arthroplasty for severe valgus deformity of the knee with extra-articular deformities of the femur and tibia using a 3-dimensional image matching software system. Int J Surg Case Rep. 2023;103:107853.

(2) Maeda T, Matsumoto T, Fujita M, Tsubosaka M, Kamenaga T, Nakano N, Kuroda Y, Hayashi S, Niikura T, Kuroda R. Successful Total Knee Arthroplasty for Hoffa and Proximal Tibial Fractures: Report of Three Complex Cases After Failed Osteosynthesis Procedures. Am J Case Rep. 2023;24:941187.

(3) Wada K, Matsumoto T, Ikuta K, Tsubosaka M, Nakano N, Maeda T, Kuroda Y, Hayashi S, Kuroda R. Acute Deterioration of Patient with Sudden Onset of Shock Caused by Group G Streptococcus Infection after Revision Total Knee Arthroplasty: A Case Report. Am J Case Rep. 2023; 24: e938905.

(4) Kitamura T, Hayashi S, Matsumoto T, Hashimoto S, Nakano N, Kuroda Y, Niikura T, Kuroda R. Pseudarthrosis of Pelvic Fracture With Charcot Arthropathy Successfully Treated With Constrained Total Hip Arthroplasty. CUREUS 2023;15:e48295.

(5) Ikuta K, Matsumoto T, Takayama K, Nakano N, Takashima Y, Ohnishi H, Hayashi S, Kuroda Y, Kuroda R. Successful Conservative Treatment of an Acute Arterial Occlusion After Total Knee Arthroplasty: Report of 2 Cases and Review of the Literature. Am J Case Rep. 2022 :24;23:e936295.

(6) Fujita M, Hayashi S, Kikuchi K, Takashima Y, Kamenaga T, Tsubosaka M, Fukuda K, Takayama K, Hashimoto S, Niikura T, Kuroda R, Matsumoto T. Sciatic Nerve Palsy following Curved Periacetabular Osteotomy. Case Rep Orthop, 2020;2020:8569285.

(7) Takashima Y, Hashimoto S, Kamenaga T, Tsubosaka M, Kuroda Y, Takeuchi K, Takayama K, Hayashi S, Kuroda R, Matsumoto T: Recurrent Hematomas following a Revision Total Hip Arthroplasty in Acquired Coagulation Factor XIII Deficiency. Case Rep Orthop, 2019; 2019:4038963
英文著書(2019年以降)
(1) Kuroda Y, Rai A, Matsumoto K, Khanduja V. Current Concepts in the Management of Femoroacetabular Impingement. Advances in Specialist Hip Surgery. Drescher WR, et al (Eds.), Springer, 2021, 115-124.