現在がん治療における分子標的薬剤は、年々新規薬剤が開発、承認されていますが、骨軟部肉腫に対して有効性が認められているものは少なく、そのメカニズムについても不明な点が多いのが現状です。IAP(Inhibitor of Apoptosis)ファミリータンパクの一つとして知られているsurvivinは、その発現抑制により細胞死を誘導し、既存抗がん薬の感受性を増強させると報告されています。骨軟部肉腫におけるsurvivinの役割を解明し、分子標的治療への臨床応用を目指した研究を行っております。また、IAPファミリータンパク質のendogenous antagonistとして作用するsmacについて,その模倣薬を用いて骨軟部肉腫における役割と既存の抗癌剤との併用効果について、研究を行っております。
1) Hara H, Sakai Y, Kawamoto T, Fukase N, Kawakami Y, Takemori T, Fujiwara S, Kitayama K, Yahiro S, Miyamoto T, Kakutani K, Niikura T, Miyazaki D, Okada T, Sakashita A, Imamura Y, Sasaki R, Kizawa Y, Minami H, Matsumoto T, Matsushita T, Kuroda R, Akisue T. Surgical outcomes of metastatic bone tumors in the extremities (Surgical outcomes of bone metastases). J Bone Oncol. 2021;27:100352.
2) Kitayama K, Kawamoto T, Kawakami Y, Hara H, Takemori T, Fujiwara S, Yahiro S, Miyamoto T, Mifune Y, Hoshino Y, Kakutani K, Matsumoto T, Matsushita T, Niikura T, Kuorada R, Akisue T. Regulatory roles of miRNAs 16, 133a, and 223 on osteoclastic bone destruction caused by breast cancer metastasis. Int J Oncol. 2021;59(5):97.
3) Takemori T, Kawamoto T, Morishita M, Hara H, Fukase N, Kawakami Y, Fujiwara S, Kitayama K, Yahiro S, Miyamoto T, Fujimoto T, Fujita I, Mifune Y, Hoshino Y, Kakutani K, Matsumoto T, Matsushita T, Niikura T, Kuroda R, Akisue T. Clinical Outcome of the Patients With Brain Metastasis from Soft Tissue Sarcomas. Anticancer Res. 2021;41(2):1027-1034.
4) Fujimoto T, Suzuki M, Kuratsu S, Fujita I, Morishita M, Sudo T, Sakuma T, Nakamatsu Y, Sakurai Y, Takata T, Tamari Y, Tanaka H, Masunaga SI, Kinashi Y, Kondo N, Sakakibara S, Igaki H, Andoh T, Sakamoto S, Kawamoto T, Watabe T, Hara H, Fukase N, Kawakami Y, Matsumoto T, Akisue T, Ono K, Ichikawa H, Kuroda R, Hirose T. BNCT for primary synovial sarcoma. Appl Radiat Isot. 2021;169:109407.
5) Kawakami Y, Nonaka K, Fukase N, Amore A, Murata Y, Quinn P, Luketich S, Takayama K, Patel KG, Matsumoto T, Cummins JH, Kurosaka M, Kuroda R, Wagner WR, Fu FH, Huard J. A Cell-free Biodegradable Synthetic Artificial Ligament for the Reconstruction of Anterior Cruciate Ligament in a Rat Model. Acta Biomater. 2021;121:275-287.
6) Kohsaka S, Hirata M, Ikegami M, Ueno T, Kojima S, Sakai T, Ito K, Naka N, Ogura K, Kawai A, Iwata S, Okuma T, Yonemoto T, Kobayashi H, Suehara Y, Hiraga H, Kawamoto T, Motoi T, Oda Y, Matsubara D, Matsuda K, Nishida Y, Mano H. Comprehensive molecular and clinicopathological profiling of desmoid tumours. Eur H Cancer. 2021;145:109-120.
7) Fujiwara S, Kawamoto T, Kawakami Y, Koterazawa Y, Hara H, Takemori T, Kitayama K, Yahiro S, Kakutani K, Matsumoto T, Matsushita T, Niikura T, Koyanagi-Aoi M, Aoi T, Kuroda R, Akisue T. Acquisition of cancer stem cell properties in osteosarcoma cells by defined factors. Stem Cell Res Ther. 2020;11(1):429.
8) Kawamoto T, Hara H, Morishita M, Fukase N, Kawakami Y, Takemori T, Fujiwara S, Kitayama K, Yahiro S, Miyamoto T, Fujimoto T, Fujita I, Kakutani K, Matsumoto T, Matsushita T, Niikura T, Kuroda R, Akisue T. Prognostic influence of the treatment approach for pulmonary metastasis in patients with soft tissue sarcoma. Clin Exp metastasis. 2020;37(4):509-517.
9) Fujimoto T, Suzuki M, Sudo T, Fujita I, Sakuma T, Sakurai Y, Hirose T, Morishita M, Takata T, Tamari Y, Tanaka H, Andoh T, Kawamoto T, Hara H, Fukase N, kawakami Y, Shigemoto R, Matsumoto T, Ichikawa H, Ono K, Kuroda R, Akisue T. Boron neutron capture therapy for clear cell sarcoma. Appl Radiat Isot. 2020;166:109324.
10) Uemura S, Mori T, Ishiko S, Takafuji S, Nino N, Yamamoto N, Hayakawa A, Nishimura N, Hara H, Kawamoto T, Akisue T, Iijima K. Retrospective analysis of high-dose chemotherapy followed by autologous stem cell transplantation for high-risk pediatric osteosarcoma. Pediatr hematol Oncol. 2020;37(4):337-343.
11) Nagano A, Matsumoto S, Kawai A, Okuma T, Hiraga H, Matsumoto Y, Nishida Y, Yonemoto T, Hosaka M, Takahashi M, Yoshikawa H, Kunisada T, Asamura K, naka N, Emori M, Kubo T, Kawashima H, Kawamoto T, Yokoyama R, Tsukushi S, Sato K, Okamoto T, Hiraoka K, Morioka H, Tanaka K, Takagi T, Iwamoto Y, Ozaki T. Osteosarcoma in patients over 50 years of age: Multi-institutional retrospective analysis of 104 patients. J Orthop Sci. 2020;25(2):319-323.
12) Kanda Y, Kakutani K, Yurube T, Zhang Z, Miyazaki S, Kakiuchi Y, Takeoka Y, Tsujimoto R, Miyazaki K, Kawamoto T, Takada T, Hoshino Y, Tabata Y, Kuroda R. A novel topical treatment for bone metastases using a gelatin hydrogel incorporating cisplatin as a sustained release system. J Orthop Res. 2020;39(3):525-535.
13) Heng M, Gupta A, Chung PW, Healey JH, Vaynrub M, Rose PS, Houdek MT, Lin PP, Bishop AJ, Hornicek FJ, Chen YL, Lozano-Calderon S, Holt GE, Han I, Biau D, Niu X, Bernthal NM, Ferguson PC, Wunder JS; Japanese Musculoskeletal Oncology Group (JMOG); Soft Tissue Osteosarcoma International Collaborative (STOIC). The role of chemotherapy and radiotherapy in localized extraskeletal osteosarcoma. Eur J Cancer. 2020;125:130-141.
14) Hara H, Kawamoto T, Fukase N, Kawakami Y, Takemori T, Fujiwara S, Kitayama K, Nishida K, Kuroda R, Akisue T. Gemcitabine and docetaxel combination chemotherapy for advanced bone and soft tissue sarcomas: protocol for an open-label, non-randomised, Phase 2 study. BMC Cancer. 2019;19(1):725.
15) Sekimizu M, Yoshida A, Mitani S, Asano N, Hirata M, Kubo T, Yamazaki F, Sakamoto H, Kato M, Makise N, Mori T, Yamazaki N, Sekine S, Oda I, Watanabe SI, Hiraga H, Yonemoto T, Kawamoto T, Naka N, Funauchi Y, Nishida Y, Honoki K, Kawano H, Tsuchiya H, Kunisada T, Matsuda K, Inagaki K, Kawai A, Ichikawa H. Frequent mutations of genes encoding vacuolar H+-ATPase components in granular cell tumors. Genes Chromosomes Cancer. 2019;58(6):373-380.
16) Takemori T, Kawamoto T, Ueha T, Toda M, Morishita M, Kamata E, Fukase N, Hara H, Fujiwara S, Niikura T, Kuroda R, Akisue T. Transcutaneous carbon dioxide application suppresses bone destruction caused by breast cancer metastasis. Oncol Rep. 2018;40(4):2079-2087.
17) Urakawa H, Yonemoto T, Matsumoto S, Takagi T, Asanuma K, Watanuki M, Takemoto A, Naka N, Matsumoto Y, Kawai A, Kunisada T, Kubo T, Emori M, Hiraga H, Hatano H, Tsukushi S, Nishida Y, Akisue T, Morii T, Takahashi M, Nagano A, Yoshikawa H, Sato K, Kawano M, Hiraoka K, Tanaka K, Iwamoto Y, Ozaki T. Clinical outcome of primary giant cell tumor of bone after curettage with or without perioperative denosumab in Japan: from a questionnaire for JCOG 1610 study. World J Surg Oncol. 2018;16(1):160.
18) Iwata E, Hasegawa T, Ueha T, Takeda D, Saito I, Kawamoto T, Akisue T, Sakai Y, Sasaki R, Kuroda R, Komori T. Transcutaneous carbon dioxide enhances the antitumor effect of radiotherapy on oral squamous cell carcinoma. Oncol Rep. 2018;40(1):434-442.
19) Kamata E, Kawamoto T, Ueha T, Hara H, Fukase N, Minoda M, Morishita M, Takemori T, Fujiwara S, Nishida K, Kuroda R, Kurosaka M, Akisue T. Synergistic Effects of a Smac Mimetic with Doxorubicin Against Human Osteosarcoma. Anticancer Res. 2017;37(11):6097-6106.
20) Kakutani K, Sakai Y, Maeno K, Takada T, Yurube T, Kurakawa T, Miyazaki S, Terashima Y, Ito M, Hara H, Kawamoto T, Ejima Y, Sakashita A, Kiyota N, Kizawa Y, Sasaki R, Akisue T, Minami H, Kuroda R, Kurosaka M, Nishida K. Prospective Cohort Study of Performance Status and Activities of Daily Living After Surgery for Spinal Metastasis. Clin Spine Surg. 2017;30(8):E1026-E1032.
21) Ueha T, Kawamoto T, Onishi Y, Harada R, Minoda M, Toda M, Hara H, Fukase N, Kurosaka M, Kuroda R, Akisue T, Sakai Y. Optimization of antitumor treatment conditions for transcutaneous CO2 application: An in vivo study. Oncol Rep. 2017;37(6):3688-3694.
22) Miyazaki S, Kakutani K, Sakai Y, Ejima Y, Maeno K, Takada T, Yurube T, Terashima Y, Ito M, Kakiuchi Y, Takeoka Y, Hara H, Kawamoto T, Sakashita A, Okada T, Kiyota N, Kizawa Y, Sasaki R, Akisue T, Minami H, Kuroda R, Nishida K. Quality of life and cost-utility of surgical treatment for patients with spinal metastases: prospective cohort study. Int Orthop. 2017;41(6):1265-1271.
23) Takeda D, Hasegawa T, Ueha T, Iwata E, Harada R, Sakakibara A, Kawamoto T, Minamikawa T, Sakai Y, Komori T. Induced Pluripotent-stem-cell Related Genes Contribute to De-differentiation in Oral Squamous Cell Carcinoma. Anticancer Res. 2017;37(3):1075-1082.
24) Morishita M, Kawamoto T, Hara H, Onishi Y, Ueha T, Minoda M, Katayama E, Takemori T, Fukase N, Kurosaka M, Kuroda R, Akisue T. AICAR induces mitochondrial apoptosis in human osteosarcoma cells through an AMPK-dependent pathway. Int J Oncol. 2017;50(1):23-30.
英文症例報告(2017年以降)
1) Mitani K, Kawamoto T, Hara H, Fukase N, Kawakami Y, Morishita M, Takemori T, Fujiwara S, Kitayama K, Yahiro S, Miyamoto T, Komatsu M, Jimbo N, Kuroda R, Akisue T. Chondrolipoma of the finger in a child: A case study. Mol Clin Oncol. 2021;14(1):2.
2) Kimbara S, Imamura Y, Kiyota N, Takakura H, Matsumoto S, Koyama T, Fujishima Y, Funakoshi Y, Toyoda M, Hirose T, Kanzawa M, Kawamoto T, Hara H, Minami H. Secondary C/C-rearranged sarcoma responsive to chemotherapy regimens for Ewing sarcoma: A case report. Mol Clin Oncol. 2021;14(4):68.
3) Kawakami Y, Hara H, Kawamoto T, Niikura T, Kuroda R, Akisue T. Extraskeletal Para-articular Osteochondroma of the Ankle Joint in a Child: A Case Report. JBJS Case Connect. 2020;10(2):e0274.
4) Ikuta K, Kawamoto T, Hara H, Fukase N, Morishita M, Kuroda R, Akisue T. Solitary pancreatic lesion as the initial metastasis from osteosarcoma: Report of a rare case. J Orthop Sci. 2020;25(4):724-728.
5) Komatsu M, Yamamoto N, Kawamoto T, Kawakami Y, Hara H, Uemura S, Nishimura N, Akisue T, Kuroda R, Iijima K, Jimbo N, Kanzawa M, Kajimoto K, Itoh T, Hirose T. Soft tissue tumor with novel NR1D1-MAML1 fusion in a pediatric case. Virchows Arch. 2020;477(6):891-895.
6) Komatsu M, Kawamoto T, Kanzawa M, Kawakami Y, Hara H, Akisue T, Kuroda R, Nakamura H, Hokka D, Jimbo N, Itoh T, Hirose T. A novel EWSR1-VGLL1 gene fusion in a soft tissue malignant myoepithelial tumor. Genes Chromosomes Cancer. 59(4):249-254.
7) Hara H, Kawamoto T, Fukase N, Katayama E, Takemori T, Fujiwara S, Sakai Y, Nishida K, Kuroda R, Akisue T. Successful First Gait of a Child With Hip-Disarticulation Prosthesis. Am J Phys Med Rehabil. 2018;97(10):e90-e92.
8) Morishita M, Hara H, Katayama E, Kawamoto T, Fukase N, Takemori T, Fujiwara S, Nishida K, Kuroda R, Akisue T. Huge chronic expanding hematoma of the iliac bone following multiple hip surgeries: a case report. J Med Case Rep. 2018;12(1):265.
9) Nomura T, Sakakibara S, Moriwaki A, Kawamoto T, Suzuki S, Ishimura T, Hashikawa K, Terashi H. Low-Grade Myxofibrosarcoma of the Rectus Abdominus Muscle Infiltrating into Abdominal Cavity: A Case Report. Eplasty. 2017;17:e6.
10) Takemori T, Nakamura O, Yamagami Y, Nishimura H, Kawamoto T, Akisue T, Yamamoto T. A rare case of acute osteomyelitis due to Panton-Valentine leukocidin-positive community-acquired methicillin-resistant Staphylococcus aureus in a young healthy adult. Int J Surg Case Rep. 2017;33:4-7.