現在がん治療における分子標的薬剤は、年々新規薬剤が開発、承認されていますが、骨軟部肉腫に対して有効性が認められているものは少なく、そのメカニズムについても不明な点が多いのが現状です。IAP(Inhibitor of Apoptosis)ファミリータンパクの一つとして知られているsurvivinは、その発現抑制により細胞死を誘導し、既存抗がん薬の感受性を増強させると報告されています。骨軟部肉腫におけるsurvivinの役割を解明し、分子標的治療への臨床応用を目指した研究を行っております。また、IAPファミリータンパク質のendogenous antagonistとして作用するsmacについて,その模倣薬を用いて骨軟部肉腫における役割と既存の抗癌剤との併用効果について、研究を行っております。
(1) Hara H, Kawamoto T, Fukase N, Kawakami Y, Takemori T, Fujiwara S, Kitayama K, Nishida K, Kuroda R, Akisue T.Gemcitabine and docetaxel combination chemotherapy for advanced bone and soft tissue sarcomas: protocol for an open-label, non-randomised, Phase 2 study. BMC Cancer.2019;19(1):725.
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(3) Kitayama K, Kawakami Y, Fukui T, Oe K, Kuroda R, Niikura T. Rescue of ankylosing hip following open reduction and internal fixation of acetabular fracture by surgical resection of heterotopic ossification: A case report. Int J Surg Case Rep. 2018;53:107-111.
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(7) Hara H, Akisue T, Kawamoto T, Onishi Y, Fujioka H, Nishida K, Kuroda R, Kurosaka M, Akisue T. Reconstruction of the Midfoot Using a Free Vascularized Fibular Graft After En Bloc Excision for Giant Cell Tumor of the Tarsal Bones: A Case Report. J Foot Ankle Surg. 2015 Jul S1067-2516(15):183-0