がん分野

• Keisuke Nakatani, Tomohiko Maehama, Miki Nishio, Junji Otani, Keiko Yamaguchi, Miki Fukumoto, Hiroki Hikasa, Shinji Hagiwara, Hiroshi Nishina, Tak Wah Mak, Teruki Honma, Yasumitsu Kondoh, Hiroyuki Osada, Minoru Yoshida, Akira Suzuki. Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation. Cancer Science,112(10): 4303-4316, 2021. doi:10.1111/cas.15079 PMID:34289205
• Yosuke Miyachi, Miki Nishio, Junji Otani, Shinji Matsumoto, Akira Kikuchi, Tak Wah Mak, Tomohiko Maehama, Akira Suzuki. TAZ inhibits acinar cell differentiation but promotes immature ductal cell proliferation in adult mouse salivary glands.Genes to Cells, 26(9): 714-726, 2021. doi:10.1111/gtc.12879 PMID:34142411
• Morioka S, Nakanishi H, Yamamoto T, Hasegawa J, Tokuda E, Hikita T, Sakihara T, Zhang Y, Oneyama C, Yamazaki M, Suzuki A, Sasaki J, Sasaki T, A mass spectrometric method for in-depth profiling of phosphoinositide regioisomers and their disease-associated regulation. Nature Communications,13(1):83. 2022. doi:10.1038/s41467-021-27648-z PMID:35013169
• Akihiro Watanabe, Kimihiro Yamashita, Mitsugu Fujita, Akira Arimoto, Masayasu Nishi, Shiki Takamura, Masafumi Saito, Kota Yamada, Kyosuke Agawa, Tomosuke Mukoyama, Masayuki Ando, Shingo Kanaji, Takeru Matsuda, Taro Oshikiri, Yoshihiro Kakeji. Vaccine Based on Dendritic Cells Electroporated with an Exogenous Ovalbumin Protein and Pulsed with Invariant Natural Killer T Cell Ligands Effectively Induces Antigen-Specific Antitumor Immunity. Cancers, 14(1), 2021. doi:10.3390/cancers14010171 PMID:35008335
• Taro Oshikiri, Hodaka Numasaki, Junya Oguma, Yasushi Toh, Masayuki Watanabe, Manabu Muto, Yoshihiro Kakeji, Yuichiro Doki Prognosis of Patients with Esophageal Carcinoma following Routine Thoracic Duct Resection: A Propensity-matched Analysis of 12,237 Patients based on the Comprehensive Registry of Esophageal Cancer in Japan Annals of Surgery, 2021. doi:10.1097/SLA.0000000000005340 PMID:34913902
• Mehmet Ozgur Avincsal, Koki Kamizaki, Naoe Jimbo, Hirotaka Shinomiya, Ken-Ichi Nibu, Michiru Nishita, Yasuhiro Minami, Oncogenic E6 and/or E7 proteins drive proliferation and invasion of human papilloma virus positive head and neck squamous cell cancer through upregulation of Ror2 expression. Oncology Reports, 46(1), 2021. doi:10.3892/or.2021.8099 PMID:34080643
• Nishida, H, Okada, M, Yang, L., Takano, T, Tabata, S, Soga, T, Ho, D M, Chung, J, Minami Y, Yoo, S K, Methionine restriction breaks obligatory coupling of cell proliferation and death by an oncogenic Src in Drosophila eLife, 10. doi:10.7554/eLife.59809 PMID:33902813
• Murao, N, Yokoi, N, Takahashi, H, Hayami, T, Minami Y, Seino, S, Increased glycolysis affects β-cell function and identity in aging and diabetes. Molecular. Metabolism, 55:101414. doi:10.1016/j.molmet.2021.101414 PMID:34871777
• Akihiro Kaneshige, Takayuki Kaji, Lidan Zhang, Hayato Saito, Ayasa Nakamura, Tamaki Kurosawa, Madoka Ikemoto-Uezumi, Kazutake Tsujikawa, Shigeto Seno, Masatoshi Hori, Yasuyuki Saito, Takashi Matozaki, Kazumitsu Maehara, Yasuyuki Ohkawa, Michael Potente, Shuichi Watanabe, Thomas Braun, Akiyoshi Uezumi, So-Ichiro Fukada Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load. Cell Stem Cell,29(2): 265-280, 2022. doi:10.1016/j.stem.2021.11.003 PMID:34856120
• Mariko Sakamoto, Yoji Murata, Daisuke Tanaka, Yuka Kakuchi, Takeshi Okamoto, Daisuke Hazama, Yasuyuki Saito, Takenori Kotani, Hiroshi Ohnishi, Masayuki Miyasaka, Masato Fujisawa, Takashi Matozaki, Anticancer efficacy of monotherapy with antibodies to SIRPα/SIRPβ1 mediated by induction of antitumorigenic macrophages. Proceedings of the National Academy of Sciences of the United States of America, 119(1), 2022. doi:10.1073/pnas.2109923118 PMID:34949714
• Takenori Kotani, Noriko Ihara, Saki Okamoto, Jajar Setiawan, Tasuku Konno, Yasuyuki Saito, Yoji Murata, Takashi Matozaki, Role of Ras in regulation of intestinal epithelial cell homeostasis and crosstalk with Wnt signaling. PLOS One, 16(8): e0256774, 2021. doi:10.1371/journal.pone.0256774 PMID:34437645
• Kohei Tanigawa, Shuichi Tsukamoto, Yu-ichiro Koma, Yu Kitamura, Satoshi Urakami, Masaki Shimizu, Masataka Fujikawa, Takayuki Kodama, Mari Nishio, Manabu Shigeoka, Yoshihiro Kakeji, Hiroshi Yokozaki, S100A8/A9 Induced by Interaction with Macrophages in Esophageal Squamous Cell Carcinoma Promotes the Migration and Invasion of Cancer Cells via Akt and p38 MAPK Pathways. The American Journal of Pathology, 198(3): 536-552, 2022. doi:10.1016/j.ajpath.2021.12.002
• Masaki Shimizu, Yu-ichiro Koma, Hiroki Sakamoto, Shuichi Tsukamoto, Yu Kitamura, Satoshi Urakami, Kohei Tanigawa, Takayuki Kodama, Nobuhide Higashino, Mari Nishio, Manabu Shigeoka, Yoshihiro Kakeji, Hiroshi Yokozaki, Metallothionein 2A Expression in Cancer-Associated Fibroblasts and Cancer Cells Promotes Esophageal Squamous Cell Carcinoma Progression. Cancers, 13(18): 4552-4552, 2021. doi:10.3390/cancers13184552
• Masataka Fujikawa, Yu-ichiro Koma, Masayoshi Hosono, Naoki Urakawa, Kohei Tanigawa, Masaki Shimizu, Takayuki Kodama, Hiroki Sakamoto, Mari Nishio, Manabu Shigeoka, Yoshihiro Kakeji, Hiroshi Yokozaki, CCL1 Derived from Tumor-Associated Macrophages Contributes to Esophageal Squamous Cell Carcinoma Progression via CCR8-mediated Akt/PRAS40/mTOR Pathway The American Journal of Pathology, 191(4): 686-703, 2021. doi:10.1016/j.ajpath.2021.01.004, PMID: 33460563
• Kazuya Tsujita, Reiko Satow, Shinobu Asada, Yoshikazu Nakamura, Luis Arnes, Keisuke Sako, Yasuyuki Fujita, Kiyoko Fukami, Toshiki Itoh, Homeostatic membrane tension constrains cancer cell dissemination by counteracting BAR protein assembly. Nature Communications, 12(1): 5930, 2021. doi:10.1038/s41467-021-26156-4 PMID:34635648
• Tomoko Kamasaki, Yumi Miyazaki, Susumu Ishikawa, Kazuya Hoshiba, Keisuke Kuromiya, Nobuyuki Tanimura, Yusuke Mori, Motosuke Tsutsumi, Tomomi Nemoto, Ryota Uehara, Shiro Suetsugu, Toshiki Itoh, Yasuyuki Fujita FBP17-mediated finger-like membrane protrusions in cell competition between normal and RasV12-transformed cells. iScience, 24(9): 102994-102994, 2021. doi:10.1016/j.isci.2021.102994 PMID:34485872
• Lu Yan, Kazuya Tsujita, Yasuyuki Fujita, Toshiki Itoh, PTEN is required for the migration and invasion of Ras-transformed MDCK cells. FEBS Letters, 595(9): 1303-1312, 2021. doi:10.1002/1873-3468.14053 PMID:33540467

代謝分野

• Hiromi Oda, Satona Tanaka, Masakazu Shinohara, Yuki Morimura, Yuhei Yokoyama, Hidenao Kayawake, Yoshito Yamada, Yojiro Yutaka, Akihiro Ohsumi, Daisuke Nakajima, Masatsugu Hamaji, Toshi Menju, Hiroshi Date, Specialized Proresolving Lipid Meditators Agonistic to Formyl Peptide Receptor Type 2 Attenuate Ischemia-reperfusion Injury in Rat Lung. Transplantation, 106(6):1159-1169 2021. doi:10.1097/TP.0000000000003987 PMID:34873128
• Naofumi Yoshida, Tomoya Yamashita, Tatsunori Osone, Tetsuya Hosooka, Masakazu Shinohara, Seiichi Kitahama, Kengo Sasaki, Daisuke Sasaki, Takeshi Yoneshiro, Tomohiro Suzuki, Takuo Emoto, Yoshihiro Saito, Genki Ozawa, Yushi Hirota, Yasuyuki Kitaura, Yoshiharu Shimomura, Yuko Okamatsu-Ogura, Masayuki Saito, Akihiko Kondo, Shingo Kajimura, Takeshi Inagaki, Wataru Ogawa, Takuji Yamada, Ken-Ichi Hirata, Bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity. iScience, 24(11): 103342-103342, 2021. doi:10.1016/j.isci.2021.103342 PMID:34805797
• Tomohide Suzuki, Shinichi Ishii, Masakazu Shinohara, Yuko Kawano, Kanako Wakahashi, Hiroki Kawano, Akiko Sada, Kentaro Minagawa, Michito Hamada, Satoru Takahashi, Tomoyuki Furuyashiki, Nguan Soon Tan, Toshimitsu Matsui, Yoshio Katayama, Mobilization efficiency is critically regulated by fat via marrow PPARδ. Haematologica, 106(6): 1671-1683, 2021. doi:10.3324/haematol.2020.265751 PMID:33538151
• Takuo Emoto, Tomohiro Hayashi, Tokiko Tabata, Tomoya Yamashita, Hikaru Watanabe, Tomoya Takahashi, Yasuhiro Gotoh, Kenjiro Kami, Naofumi Yoshida, Yoshihiro Saito, Hidekazu Tanaka, Kensuke Matsumoto, Tetsuya Hayashi, Takuji Yamada, Ken-Ichi Hirata, Metagenomic analysis of gut microbiota reveals its role in trimethylamine metabolism in heart failure. International Journal of Cardiology, 338: 138-142, 2021. doi:10.1016/j.ijcard.2021.06.003 PMID:34102245
• Hiroyuki Yamamoto, Toshiro Shinke, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Masaru Kuroda, Yushi Hirota, Kazuhiko Sakaguchi, Wataru Ogawa, Ken-Ichi Hirata, Impact of daily glucose fluctuations on cardiovascular outcomes after percutaneous coronary intervention for patients with stable coronary artery disease undergoing lipid-lowering therapy. Journal of Diabetes Investigation, 12(6): 1015-1024, 2021. doi:10.1111/jdi.13448 PMID:33098191
• Tomoya Yamashita, Naofumi Yoshida, Takuo Emoto, Yoshihiro Saito, Ken-Ichi Hirata, Two Gut Microbiota-Derived Toxins Are Closely Associated with Cardiovascular Diseases: A Review, Toxins, 13(5), 2021. doi:10.3390/toxins13050297 PMID:33921975
• Yumiko Saijo-Hamano, Aalaa Alrahman Sherif, Ariel Pradipta, Miwa Sasai, Naoki Sakai, Yoshiaki Sakihama, Masahiro Yamamoto, Daron M Standley, Ryo Nitta Structural basis of membrane recognition of Toxoplasma gondii vacuole by Irgb6. Life Science Alliance, 5(1), 2022. doi:10.26508/lsa.202101149 PMID 34753804
• Shinya Taguchi, Juri Nakano, Tsuyoshi Imasaki, Tomoki Kita, Yumiko Saijo-Hamano, Naoki Sakai, Hideki Shigematsu, Hiromichi Okuma, Takahiro Shimizu, Eriko Nitta, Satoshi Kikkawa, Satoshi Mizobuchi, Shinsuke Niwa, Ryo Nitta, Structural model of microtubule dynamics inhibition by Kinesin-4 from the crystal structure of KLP-12 –tubulin complex. bioRxiv, 2022. doi:10.1101/2022.02.14.480441 PMID:36065637

脳こころ分野

• Yuka Ishikawa, Tomoyuki Furuyashiki, The impact of stress on immune systems and its relevance to mental illness. Neuroscience Research, 175:16-24, 2021. doi:10.1016/j.neures.2021.09.005 PMID:34606943
• Hidekazu Sotoyama, Hisaaki Namba, Yutaro Kobayashi, Taku Hasegawa, Dai Watanabe, Ena Nakatsukasa, Kenji Sakimura, Tomoyuki Furuyashiki, Hiroyuki Nawa, Resting-state dopaminergic cell firing in the ventral tegmental area negatively regulates affiliative social interactions in a developmental animal model of schizophrenia. Translational Psychiatry, 11(1): 236-236, 2021. doi:10.1038/s41398-021-01346-2 PMID:33888687
• Timothy T. Rogers, Christopher R. Cox, Qihong Lu, Akihiro Shimotake, Takayuki Kikuch, Takeharu Kunieda, Susumu Miyamoto, Ryosuke Takahashi, Akio Ikeda, Riki Matsumoto, Matthew A.Lambon Ralph, Evidence for a deep, distributed and dynamic code for animacy in human ventral anterior temporal cortex. eLife, 10, 2021. doi:10.7554/eLife.66276 PMID: 34704935
• Naoyuki Sato, Riki Matsumoto, Akihiro Shimotake, Masao Matsuhashi, Mayumi Otani, Takayuki Kikuchi, Takeharu Kunieda, Hiroaki Mizuhara, Susumu Miyamoto, Ryosuke Takahashi, Akio Ikeda, Frequency-Dependent Cortical Interactions during Semantic Processing: An Electrocorticogram Cross-spectrum Analysis Using a Semantic Space Model. Cerebral Cortex, 31(9): 4329-4339, 2021. doi:10.1093/cercor/bhab089 PMID:33942078
• Naohiko Seike, Akio Yokoseki, Ryoko Takeuchi, Kento Saito, Hiroaki Miyahara, Akinori Miyashita, Tetsuhiko Ikeda, Izumi Aida, Takashi Nakajima, Masato Kanazawa, Masatoshi Wakabayashi, Yasuko Toyoshima, Hitoshi Takahashi, Riki Matsumoto , Tatsushi Toda, Osamu Onodera, Atsushi Ishikawa, Takeshi Ikeuchi, Akiyoshi Kakita, Genetic Variations and Neuropathologic Features of Patients With PRKN Mutations. Movement Disorders, 36(7):1634-1643, 2021. doi:10.1002/mds.28521 PMID:33570211
• Jun Nomura, Matthew Mardo, Toru Takumi, Molecular signatures from multi‐omics of autism spectrum disorders and schizophrenia. Journal of Neurochemistry, 159(4):647-659, 2021. doi:10.1111/jnc.15514 PMID: 34537986
• Kota Tamada, Keita Fukumoto, Tsuyoshi Toya, Nobuhiro Nakai, Janak R Awasthi, Shinji Tanaka, Shigeo Okabe, François Spitz, Fumihito Saitow, Hidenori Suzuki, Toru Takumi, Genetic dissection identifies Necdin as a driver gene in a mouse model of paternal 15q duplications Nature Communications, 12(1): 4056-4056, 2021. doi:10.1038/s41467-021-24359-3 PMID:34210967
• Tomokazu Tsurugizawa, Kota Tamada, Clement Debacker, Andrew Zalesky, Toru Takumi, Cranioplastic Surgery and Acclimation Training for Awake Mouse fMRI. BIO-PROTOCOL, 11(7), 2021. doi:10.21769/bioprotoc.3972 PMID: 33889666
• Hiroaki Mohri, Yuzuru Ninoyu, Hirofumi Sakaguchi, Shigeru Hirano, Naoaki Saito, Takehiko Ueyama, Nox3-Derived Superoxide in Cochleae Induces Sensorineural Hearing LossThe Journal of Neuroscience , 41(21): 4716-4731, 2021. doi:10.1523/JNEUROSCI.2672-20.2021 PMID:33849947
• Takahiro Nakano, Norio Chihara, Kento Matoba, Hisatsugu Tachibana, Shiho Okuda, Yoshihisa Otsuka, Takehiro Ueda, Kenji Sekiguchi, Hisatomo Kowa, Frank Leypoldt, Klaus-Peter Wandinger, Riki Matsumoto, A Case of Immunotherapy-responsive Non-paraneoplastic Encephalitis with Antibodies Against GAD, LGI1, and GABAA Receptor Internal Medicine, 61(3):419-423, 2021. doi:10.2169/internalmedicine.7846-21 PMID:34334569
• Shunsuke Murata, Rei Ono, Hisafumi Yasuda, Rumi Tanemura, Yoshiaki Kido, Hisatomo Kowa, Effect of a Combined Exercise and Cognitive Activity Intervention on Cognitive Function in Community-dwelling Older Adults: A Pilot Randomized Controlled Trial. Physical Therapy Research, 24(2): 112-119, 2021. doi:10.1298/ptr.E10057 PMID:34532206
• Yoji Nagai, Shinsuke Kojima, Hisatomo Kowa, Yasuji Yamamoto, Hiroyuki Kajita, Tohmi Osaki, Yasumasa Kakei, Kavita U. Kothari, Ryoma Kayano, Kobe project for the exploration of newer strategies to reduce the social burden of dementia: a study protocol of cohort and intervention studies. BMJ OPEN, 11(6): e050948-, 2021. doi:10.1136/bmjopen-2021-050948 PMID:34145022

AI・デジタルヘルス/医療機器分野

• Yaming Wang, Masahiro Okada, Shi Chao Xie, Yu Yang Jiao, Emilio Satoshi Hara, Hiroaki Yanagimoto, Takumi Fukumoto, Takuya Matsumoto Immediate soft-tissue adhesion and the mechanical properties of the Ti-6Al-4V alloy after long-term acid treatment. Journal of Materials Chemistry B, 9(39): 8348-8354, 2021. doi:10.1039/d1tb00919b PMID:34533175
• Motofumi Tanaka, Shohei Komatsu, Masahiro Kido, Hirochika Toyama, Masahiro Tominaga, Yoichiro Uchida, Kazuki Terashima, Yusuke Demizu, Tomoaki Okimoto, Takumi Fukumoto, Salvage hepatectomy for local recurrence after particle therapy using proton and carbon ion beams for liver cancer. Annals of Gastroenterological Surgery, 5(5): 711-719, 202109. doi:10.1002/ags3.12468 PMID:34585055
• Young-Min Yang, Kayo Osawa, Koichi Kitagawa, Samiko Hosoya, Reo Onishi, Aya Ishii, Toshiro Shirakawa, Itaru Hirai, Kuntaman Kuntaman, Hiroshi Tanimoto, Katsumi Shigemura, Masato Fujisawa, Differential effects of chromosome and plasmid blaCTX-M-15 genes on antibiotic susceptibilities in extended-spectrum beta-lactamase-producing Escherichia coli isolates from patients with urinary tract infection. International Journal of Urology, 28(6): 623-628, 2021. doi:10.1111/iju.14498 PMID:33811389
• Nobuyuki Hinata, Ryoichi Shiroki, Kazunari Tanabe, Masatoshi Eto, Atsushi Takenaka, Mutsushi Kawakita, Isao Hara, Fumiya Hongo, Naokazu Ibuki, Yasutomo Nasu, Jun Teishima, Noriyasu Kawai, Akihiro Kawauchi, Tsunenori Kondo, Naoki Kawamorita, Chikara Oyama, Shigeo Horie, Masaki Shimbo, Masashi Kato, Hiroomi Kanayama, Yuya Koito, Masato Fujisawa Robot-assisted partial nephrectomy versus standard laparoscopic partial nephrectomy for renal hilar tumor: A prospective multi-institutional study. International Journal of Urology, 28(4): 382-389, 2021. doi:10.1111/iju.14469 PMID:33368639
• Taku Nose, Yoshinori Imamura, Shinya Ohata, Shiro Kimbara, Yoshiharu Miyata, Yasuko Hyogo, Yoshimi Fujishima, Yohei Funakoshi, Masanori Toyoda, Naomi Kiyota, Hironobu Minami, Incidence of venous thromboembolism in patients with solid cancers in Japan: retrospective study of 2735 patients. International Journal of Hematology, 114(3): 319-324, 2021. doi:10.1007/s12185-021-03167-x PMID:34091877
• Masahiro Mizuno, Behnoush Khaledian, Masao Maeda, Takanori Hayashi, Seiya Mizuno, Eiji Munetsuna, Takashi Watanabe, Seishi Kono, Seiji Okada, Motoshi Suzuki, Shintaro Takao, Hironobu Minami, Naoya Asai, Fumihiro Sugiyama, Satoru Takahashi, Yohei Shimono, Adipsin-Dependent Secretion of Hepatocyte Growth Factor Regulates the Adipocyte-Cancer Stem Cell Interaction Cancers, 13(16), 2021. doi:10.3390/cancers13164238 PMID:34439392
• Hironobu Minami, Naomi Kiyota, Shiro Kimbara, Yuichi Ando, Tomoya Shimokata, Atsushi Ohtsu, Nozomu Fuse, Yasutoshi Kuboki, Toshio Shimizu, Noboru Yamamoto, Kazuto Nishio, Yutaka Kawakami, Shin ichi Nihira, Kazuhiro Sase, Takahiro Nonaka, Hideaki Takahashi, Yukiko Komori, Koshin Kiyohara Guidelines for clinical evaluation of anti-cancer drugs Cancer Science, 112(7): 2563-2577, 2021. doi:10.1111/cas.14967 PMID:33990993
• Shigeyuki Matsumoto, Haruka Taniguchi-Tamura, Mitsugu Araki, Takashi Kawamura, Ryo Miyamoto, Chiemi Tsuda, Fumi Shima, Takashi Kumasaka, Yasushi Okuno, Tohru Kataoka,Oncogenic mutations Q61L and Q61H confer active form-like structural features to the inactive state (state 1) conformation of H-Ras protein Biochemical and Biophysical Research Communications, 565: 85-90, 2021. doi:10.1016/j.bbrc.2021.05.084 PMID:34102474
• Kawamura I, Seki H, Tajima S, Makino Y, Shigeta A, Okitsu T, Wada A, Naito A, Sudo Y, Structure of a retinal chromophore of dark-adapted middle rhodopsin as studied by solid-state nuclear magnetic resonance spectroscopy Biophys Physicobiol, 18. doi:10.2142/biophysico.bppb-v18.019 PMID:34434690

再生医学分野

• Shinichi Nishi, Shunsuke Goto, Makiko Mieno, Takashi Yagisawa, Kenji Yuzawa, The Modified Chronic Kidney Disease Epidemiology Collaboration Equation for the Estimated Glomerular Filtration Rate Is Better Associated with Comorbidities than Other Equations in Living Kidney Donors in Japan Internal Medicine, 60(17): 2757-2764, 2021. doi:10.2169/internalmedicine.6934-20 PMID:33716291
• Mao Shimizu, Hideki Fujii, Keiji Kono, Kentaro Watanabe, Shunsuke Goto, Kandai Nozu, Kimitoshi Nakamura, Shinichi Nishi Screening for Fabry disease among male patients on hemodialysis in Awaji Island Therapeutic Apheresis and Dialysis, 2022. doi:10.1111/1744-9987.13834 PMID:35261182
• Shunsuke Goto, Hideyo Oguchi, Ken Sakai, Tetsuo Mikami, Daisuke Ichikawa, Masahiko Yazawa, Junki Koike, Kengo Furuichi, Masahiko Kawabata, Hitoshi Yokoyama, Tadashi Sofue, Emi Ibuki, Shinichi Nishi Correction to: Association between expanded criteria for living kidney donors and renal biopsy findings Journal of Nephrology, 2022. doi:10.1007/s40620-022-01285-1 PMID:35175582
• Takaki Ishida, Michiyo Koyanagi-Aoi, Daisuke Yamamiya, Atsushi Onishi, Katsuya Sato, Keiichiro Uehara, Masato Fujisawa, Takashi Aoi Differentiation of Human Induced Pluripotent Stem Cells Into Testosterone-Producing Leydig-like Cells Endocrinology, 162(12), 2021. doi:10.1210/endocr/bqab202 PPMID: 34549267
• MarikoTaniguchi-Ikeda, MichiyoKoyanagi-Aoi, TatsuoMaruyama, ToruTakaori, AkikoHosoya, HiroyukiTezuka, ShotaroNagase, TakumaIshihara, TaisukeKadoshima, KeikoMuguruma, KeikoIshigaki, HidetoshiSakurai, AkiraMizoguchi, Bennett G.Novitch, TatsushiToda, MomokoWatanabe, Takashi Aoi Restoration of the defect in radial glial fiber migration and cortical plate organization in a brain organoid model of Fukuyama muscular dystrophy iScience, 24(10), 2021 DOI: 10.1016/j.isci.2021.103140 PMID: 34632335
• Keiichiro Uehara, Michiyo Koyanagi-Aoi, Takahiro Koide, Tomoo Itoh, Takashi Aoi Epithelial-derived factors induce muscularis mucosa of human induced pluripotent stem cell-derived gastric organoids Stem Cell Reports, 17(4):820-834, 2022. doi:10.1016/j.stemcr.2022.02.002 PMID:35245440
• Yuichi Kuroda, Shingo Hashimoto, Masayoshi Saito, Tomoyuki Matsumoto, Naoki Nakano, Ryosuke Kuroda, Shinya Hayashi Femoro-Epiphyseal Acetabular Roof (FEAR) Index and Anterior Acetabular Coverage Correlate With Labral Length in Developmental Dysplasia of the Hip Arthroscopy, 38(2):374-381, 2021. doi:10.1016/j.arthro.2021.04.051 PMID:33964382
• Shinya Hayashi, Shingo Hashimoto, Yuichi Kuroda, Naoki Nakano, Tomoyuki Matsumoto, Kazunari Ishida, Nao Shibanuma, Tomoyuki Kamenaga, Ryosuke Kuroda Accuracy of cup position following robot-assisted total hip arthroplasty may be associated with surgical approach and pelvic tilt Scientific Reports, 11(1): 7578-7578, 2021. doi:10.1038/s41598-021-86849-0 PMID:33828113
• Hitomi Hara, Yoshitada Sakai, Teruya Kawamoto, Naomasa Fukase, Yohei Kawakami, Toshiyuki Takemori, Shuichi Fujiwara, Kazumichi Kitayama, Shunsuke Yahiro, Tomohiro Miyamoto, Kenichiro Kakutani, Takahiro Niikura, Daisuke Miyawaki, Takuya Okada, Akihiro Sakashita, Yoshinori Imamura, Ryohei Sasaki, Yoshiyuki Kizawa, Hironobu Minami, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda, Toshihiro Akisue, Surgical outcomes of metastatic bone tumors in the extremities (Surgical outcomes of bone metastases) Journal of Bone Oncology, 27: 100352-100352, 2021. doi:10.1016/j.jbo.2021.100352 PMID:33850700
• Toshihiro Uesaka, Mitsumasa Okamoto, Mayumi Nagashimada, Yoshihiro Tsuda, Miho Kihara, Hiroshi Kiyonari, Hideki Enomoto Enhanced enteric neurogenesis by Schwann cell precursors in mouse models of Hirschsprung disease Glia, 69(11): 2575-2590, 2021. doi:10.1002/glia.24059 PMID:34272903
• Mukhamad Sunardi, Keisuke Ito, Hideki Enomoto Live visualization of a functional RET‐EGFP chimeric receptor in homozygous knock‐in mice Development, Growth & Differentiation, 63(6): 285-294, 2021. doi:10.1111/dgd.12740 PMID: 34324195
• Mitsumasa Okamoto, Toshihiro Uesaka, Keisuke Ito, Hideki Enomoto Increased RET Activity Coupled with a Reduction in the RET Gene Dosage Causes Intestinal Aganglionosis in Mice eNeuro, 8(3): ENEURO.0534-20.2021, 2021. doi:10.1523/eneuro.0534-20.2021 PMID: 33958373

免疫・炎症分野

• Gyanu Parajuli, Murat Tekguc, James B Wing, Ari Hashimoto, Daisuke Okuzaki, Takeshi Hirata, Atsushi Sasaki, Takahide Itokazu, Haruka Handa, Hirokazu Sugino, Yoshihiro Nishikawa, Hozaifa Metwally, Yuzo Kodama, Shinya Tanaka, Hisataka Sabe, Toshihide Yamashita, Shimon Sakaguchi, Tadamitsu Kishimoto, Shigeru Hashimoto Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression Cancer Immunology Research, 9(8): 862-876, 2021. doi:10.1158/2326-6066.CIR-21-0014 PMID:34006522
• Katsutoshi Kuriyama, Yuzo Kodama, Masahiro Shiokawa, Yoshihiro Nishikawa, Saiko Marui, Takeshi Kuwada, Yuko Sogabe, Nobuyuki Kakiuchi, Teruko Tomono, Tomoaki Matsumori, Atsushi Mima, Toshihiro Morita, Tatsuki Ueda, Motoyuki Tsuda, Yuki Yamauchi, Yojiro Sakuma, Yuji Ota, Takahisa Maruno, Norimitsu Uza, Ryoichiro Kageyama, Tsutomu Chiba, Hiroshi Seno Essential role of Notch/Hes1 signaling in postnatal pancreatic exocrine development Journal of Gastroenterology, 56(7): 673-687, 2021. doi:10.1007/s00535-021-01779-y PMID:34128109
• Takeshi Kuwada, Masahiro Shiokawa, Yuzo Kodama, Sakiko Ota, Nobuyuki Kakiuchi, Yasuhito Nannya, Hajime Yamazaki, Hiroyuki Yoshida, Takeharu Nakamura, Shimpei Matsumoto, Yuya Muramoto, Shuji Yamamoto, Yusuke Honzawa, Katsutoshi Kuriyama, Kanako Okamoto, Tomonori Hirano, Hirokazu Okada, Saiko Marui, Yuko Sogabe, Toshihiro Morita, Tomoaki Matsumori, Atsushi Mima, Yoshihiro Nishikawa, Tatsuki Ueda, Kazuyoshi Matsumura, Norimitsu Uza, Tsutomu Chiba, Hiroshi Seno Identification of an Anti-Integrin αvβ6 Autoantibody in Patients With Ulcerative Colitis Gastroenterology, 160(7): 2383-2394, 2021. doi:10.1053/j.gastro.2021.02.019 PMID:33582126
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