がん分野

• Sudo, A., Kanagawa, M., Kondo, M., Ito, C., Kobayashi, K., Endo, M., Minami, Y., Aiba, A., Toda, T.. Temporal requirement of dystroglycan glycosylation during brain development and rescue of severe cortical dysplasia via gene delivery in the fetal stage. Human Mol. Genet.27: 1174-1185, 2018.
• Endo, M., Minami, Y.Diverse roles for the Ror-family Receptor Tyrosine Kinases in Neurons and Glial Cells during Development and Repair of the Nervous System. Dev. Dyn. 247: 24-32, 2018.
• Uehara, S., Udagawa, N., Mukai, H., Ishihara, A., Maeda, K., Yamashita, T., Murakami, K., Nishita, M., Nakamura, T., Kato, S., Minami, Y., Takahashi, N., Kobayashi, Y. Protein kinase N3 promotes bone resorption by osteoclasts in response to Wnt5a-Ror2 signaling. Sci. Signaling,., 292: 15939-15951, 2017.
• (国)Kamizaki, K., Doi, R., Hayashi, M., Saji, T., Kanagawa, M., Toda, T., Fukada, S-I., Ho, H. H., Greenberg, M. E., Endo, M., Minami, Y. The Ror1 receptor tyrosine kinase plays a crucial role in regulating satellite cell proliferation during regeneration of injured muscle. J. Biol. Chem.2(1): 89140-89140,2017. doi: 10.1172/jci.insight.89140.
• Ke, H., Matsumoto, S., Murashima, Y., Taniguchi-Tamura, H., Miyamoto, R., Yoshikawa, Y., Tsuda, C., Kumasaka, T., Mizohata, E., Edamatsu, H., and Kataoka, T. Structural basis for intramolecular interaction of post-translationally modified H-Ras•GTP prepared by protein ligation. FEBS Lett.，Vol.591, 2470-2481,2017
• Matsunaga, S., Hano, Y., Saito, Y., Fujimoto, K. J., Kumasaka, T., Matsunoto, S., Kataoka, T., Shima, F., and Tanaka, S. Structural transition of solvated H-Ras/GTP revealed by molecular dynamics simulation and local network entropy. J. Mol. Graph. Model,77, 51-63,2017
• (国)Dai H., Friday AJ., Abou-Daya KI., Williams AL., Mortin-Toth S., Nicotra ML., Rothstein DM., Shlomchik WD., Matozaki T., Isenberg JS., Oberbarnscheidt MH, Danska JS, Lakkis FG. Donor SIRPα polymorphism modulates the innate immune response to allogeneic grafts. Sci Immunol., 2, eaam6202, 2017.
• Saito, Y., Respatika, D., Komori, S., Washio K., Nishimura T., Kotani T., Murata Y., Okazawa H., Ohnishi H., Kaneko Y., Yui K., Yasutomo K., Nishigori C., Nojima Y., Matozaki T., SIRPα+ dendritic cells regulate homeostasis of fibroblastic reticular cells via TNF receptor ligands in the adult spleen. Proc. Natl. Acad. Sci. U S A., 114, E10151-E10160, 2017
• (国)Murata Y, Tanaka D, Hazama D, Yanagita T, Saito Y, Kotani T, Oldenborg PA, Matozaki T. Anti-human SIRPα antibody is a new tool for cancer immunotherapy. Cancer Sci., 2018 May;109(5):1300-1308. doi: 10.1111/cas.13548.
• Yokozaki H., Koma, Y., Shigeoka M., Nishio M., Cancer as a tissue: The significance of cancer-stromal interactions in the development, morphogenesis and progression of human upper digestive tract cancer. Pathology International, 2018 Jun;68(6):334-352. doi: 10.1111/pin.12674.
• Hosono M., Koma Y., Takase N., Urakawa N., Higashino N., Suemune K., Kodaira H., Nishio M., Shigeoka M., Kakeji Y., Yokozaki H. CXCL8 derived from tumor-associated macrophages and esophageal squamous cell carcinomas contributes to tumor progression by promoting migration and invasion of cancer cells Oncotarget, Vol.8, 106071-106088, 2017.
• Nambara S., Masuda T., Nishio M., Kuramitsu S., Tobo T., Ogawa Y., Hu Q., Iguchi T., Kuroda Y., Ito S., Eguchi H., Sugimachi K., Saeki H., Oki E., Maehara Y., Suzuki A., Mimori K. Antitumor effects of the antiparasitic agent ivermectin via inhibition of Yes-associated protein 1 expression in gastric cancer. ONCOTARGET 8(64):107666-107677, 2017.
• Kondo H., Shimono Y., Mukohyama J., Tanaka Y., Shibuya N., Minami H., Kakeji Y., Suzuki A. Discordance of MCM7 mRNA and its Intronic MicroRNA Levels Under Hypoxia. ANTICANCER RES 37(7):3885-3890, 2017.
• Yamamoto, H., Kondo, A., Itoh, T. A curvature-dependent membrane binding by tyrosine kinase Fer involves an intrinsically disordered region. Biochem. Biophys. Res. Commun., Vol.495,1522–1527, 2018.

代謝分野

• Komada, H., Sakaguchi, K., Hirota, Y., Sou, A., Nakamura, T., Kyotani, K., Kawamitsu, H., Sugimura, K., Okuno, Y., Ogawa, W. , Pancreatic fat content assessed by 1 H magnetic resonance spectroscopy is correlated with insulin resistance, but not with insulin secretion, in J apanese individuals with normal glucose tolerance J Diabetes Investig. 2017 Aug 2;9(3):505-511. doi: 10.1111/jdi.12720
• Nishimoto, Y., Nakajima, S., Tateya, S., Saito, M., Ogawa, W., Tamori, Y.. Cell death-inducing DNA fragmentation factor A-like effector A and fat-specific protein 27β coordinately control lipid droplet size in brown adipocytes. J Biol Chem.292:10824-10834, 2017.
• Komada, H., Hirota, Y., So, A., Nakamura, T., Okuno, Y., Fukuoka, H., Iguchi, G., Takahashi, Y., Sakaguchi, K., Ogawa, W. Insulin Secretion and Insulin Sensitivity Before and After Surgical Treatment of Pheochromocytoma or Paraganglioma. J Clin Endocrinol Metab. 102:3400-3405, 2017.
• Hara, T., Monguchi, T., Iwamoto, N., Akashi, M., Mori, K., Oshita, T., Okano, M., Toh, R., Irino, Y., Shinohara, M., Yamashita, Y., Shioi, G., Furuse, M., Ishida, T., Hirata, K. Targeted disruption of JCAD (Junctional protein associated with coronary artery disease)/KIAA1462, a coronary artery disease-associated gene product, inhibits angiogenic processes in vitro and in vivo. Arterioscler Thromb Vasc Biol ;37(9):1667-1673.
• Tsuda, S., Shinohara, M., Oshita, T., Nagao, M., Tanaka, N., Mori, T., Hara, T., Irino, Y., Toh, R., Ishida, T., Hirata, K. Novel mechanism of regulation of the 5-lipoxygenase/leukotriene B(4) pathway by high-density lipoprotein in macrophages. Sci Rep. 7(1):12989, 2017.
• Bando, H., Iguchi, G., Okimura, Y., Odake, Y., Yoshida, K., Matsumoto, R., Suda, K., Nishizawa, H., Fukuoka, H., Mokubo, A., Tojo, K., Maniwa, Y., Ogawa, W., Takahashi, Y.. A novel thymoma-associated autoimmune disease: Anti-PIT-1 antibody syndrome. Sci Rep. 7 43060 2017.
• Kobayashi, K., Maeda, K., Takefuji, M., Kikuchi, R., Morishita, Y., Hirashima, M., Murohara, T. Dynamics of angiogenesis in ischemic areas of the infarcted heart. Sci Rep. 7(1):7156, 2017. doi: 10.1038/s41598-017-07524-x.
• (国)Jang, JY., Choi, SY., Park, I., Park, DY., Choe, K., Kim, P., Kim, YK., Lee, BJ., Hirashima, M., Kubota, Y., Park, JW., Cheng, SY., Nagy, A., Park, YJ., Alitalo, K., Shong, M., Koh, GY. VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis. EMBO Mol Med. 9(6):750-769, 2017. doi: 10.15252/emmm.201607341.
• (国)Kawada, Y., Asahara S, Sugiura Y, Sato A, Furubayashi A, Kawamura M, Bartolome A,Terashi-Suzuki E, Takai T, Koyanagi-Kimura M, Matsuda T, Hashimoto N, Kido Y. Histone deacetylase regulates insulin signaling via two pathways in pancreatic β cells. PLoS ONE .12: e0184435, 2017.
• (国)Bartolome, A., Garcia, A., Asahara, S., Kido, Y., Gullien, C., Pajvani, UB., Benito, M. mTORC1 regulates both General Autophagy and Mitophagy Induction after Oxidative Phosphorylation Uncoupling. Mol Cell Biol. 37, e0044-17, 2017.
• (国)Ardestani, A., Lupse, B., Kido, Y., Leibowitz, G., Maedler, K.. mTORC1 Signaling: A Double-Edged Sword in Diabetic β Cells. Cell metabM. 27: 314-331.2018.

脳こころ分野

• Kato, D., Eto, K., Nabekura, J., Wake, H. Activity-dependent functions of non-electrical glia cells J Biochem. Feb 13.2018. 
• Miyamoto, A., Wake, H., Ishikawa, AW., Eto, K., Shibata, K., Murakoshi, H., Koizumi, S., Moorhouse, AJ., Yoshimura, Y., Nabekura, J. Microglia contact induces synapse formation in developing somatosensory cortex Nature Commun. Aug 25;712540, 2016.
• Kato, G., Inada, Hm. Wake, H., Akiyoshi, R., Miyamoto, A., Eto, K., Ishikawa, T., Moorhouse, AJ., Strassman, AM., Nabekura, J. Microglia contact prevents excess depolarization and rescues neurons from excitotoxicity eNeuro. 2016,Jun 21;3(3).
• Niwa, S., Nakamura, F., Tomabechi, Y., Aoki, M., Shigematsu, H., Matsumoto, T., Yamagata, A., Fukai, S., Hirokawa, N., Goshima, Y., Shirouzu, M., Nitta, R. Structural basis for CRMP2-induced axonal microtubule formation. Sci.Rep. 7: 10681. doi:10.1038/s41598-017-11031-4, 2017
• Sumi, T., Imasaki, T., Aoki, M., Sakai, N., Nitta, E., Shirouzu, M., & Nitta, R. Structural Insights into the Altering Function of CRMP2 by Phosphorylation. Cell Struct. Funct. 43:15-23. doi: 10.1247/csf.17025, 2018.
• Yamamoto, Y. and Sakisaka, T. The peroxisome biogenesis factors posttranslationally target reticulon homology domain-containing proteins to the endoplasmic reticulum membrane. Sci. Reps, Vol.8, 2322, 2018.
• Yamamoto, Y., Yurugi, C., and Sakisaka, T. The number of the C-terminal transmembrane domains has the potency to specify subcellular localization of Sec22c. Biochem. Biophys. Res. Commun., Vol.487(2), 388-395, 2017.
• Shinohara, R., Taniguchi, M., Ehrlich, AT., Yokogawa, K., Deguchi, Y., Cherasse, Y., Lazarus, M., Urade, Y., Ogawa, A., Kitaoka, S., Sawa, A., Narumiya, S., Furuyashiki, T. Dopamine D1 receptor subtype mediates acute stress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex and contributes to suppression of stress susceptibility in mice. Mol Psychiatry, ,2018 Aug;23(8):1717-1730. doi: 10.1038/mp.2017.177.
• Ota, H., Katanosaka, K., Murase, S., Furuyashiki, T., Narumiya, S., Mizumura, K. EP2 receptor plays pivotal roles in generating mechanical hyperalgesia after lengthening contractions. Scand J Med Sci Sports, 28, 826-833 (2018).

免疫・炎症分野

• (国)Wakata, A., Kanemoto, S., Tang, H., Kawabata, A., Nishimura, M., Jasirwan, C., Mahmoud, NF., *Mori Y. The Neutralizing Linear Epitope of Human Herpesvirus 6A Glycoprotein B Does Not Affect Virus Infectivity. J Virol. 2018 Feb 12;92(5). pii: e01121-17. 2018
• Nishimura, M., Wang, J., Wakata, A., Sakamoto, K., *Mori, Y. Crystal Structure of the DNA-Binding Domain of Human Herpesvirus 6A Immediate Early Protein 2. J Virol. Oct 13;91(21). pii: e01121-17.2017. 
• (国)Utsumi, T., Lusida, MI., Dinana, Z., Wahyuni, RM., Yamani, LN., Juniastuti, Soetjipto, Matsui, C., Deng, L., Abe, T., Doan, YH., Fujii, Y., Kimura, H., Katayama, K., and Shoji, I. Occurence of norovirus infection in an asymptomatic population in Indonesia. Infection, Genetics and Evolution, 2017, 55:1-7. doi: 10.1016/j.meegid.2017.08.020.
• Minami, N., Abe, T., Deng, L., Fukuhara, T., Matsuura, Y., and Shoji, I. Unconjugated interferon-stimulated gene 15 specifically interacts with the hepatitis C virus NS5A protein via domain I. Microbiology and Immunology, 61 (7): 287-292. 2017 doi: 10.1111/1348-0421.12493.
• Shichiri,H., Yamamoto, K., Tokura, M., Ishida, T., Uda, A., Bito, T., Nishigori, C. Nakagawa, T., Hirano, T., Yanoa, I., Hirai, M Prostaglandin E1 reduces the keratinocyte toxicity of sorafenib by maintaining signal transducer and activator of transcription 3 (STAT3) activity and enhancing the cAMP response element binding protein (CREB) activity. Biochem Biophys Res Commun 485(2) : 227-233, 2017
• Shimoura, N., Nagai, H., Fujiwara, S., Jimbo, H., Yoshimoto, T., Nishigori, C. Interleukin (IL)-18, cooperatively with IL-23, induces prominent inflammation and enhances psoriasis-like epidermal hyperplasia. Arch Dermatol Res 309(4) : 315-321, 2017
• Makoto Kunisada, Chieko Hosaka, Chihiro Takemori, Eiji Nakano, Chikako Nishigori CXCL1 inhibition regulates UVB-induced skin inflammation and tumorigenesis in Xpa-deficient mice. J Invest Dermatol 137(9) : 1975-1983, 2017
• Sendo S, Saegusa J, Okano T, Takahashi S, Akashi K, Morinobu A. CD11b+ Gr1dim Tolerogenic Dendritic Cell-like Cells are Expanded in Interstitial Lung Disease in SKG Mice.　Arthritis Rheumatol. 2017 Dec;69(12):2314-2327
• Takahashi S, Saegusa J, Sendo S, Okano T, Akashi K, Irino Y, Morinobu A. Glutaminase 1 plays a key role in the cell growth of fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Res Ther. 2017 Apr 11;19(1):76.
• Chen, M., Aoki-Utsubo, C., Kameoka, M., Deng, L., Terada, Y., Kamitani, W., Sato, K., Koyanagi, Y., Hijikata, M., Shindo, K., Noda, T., Kohara, M. and Hotta, H. Broad-spectrum antiviral agents: secreted phospholipase A2 targets viral envelope lipid bilayers derived from the endoplasmic reticulum membrane. Sci. Rep. 7(1): 15931, 2017.

創薬分野

• (国) Ashraf, S., Kudo, H., Rao, J., Kikuchi, A., Widmeier, E., Lawson, A. J., Tan, W., Hermle, T., Warejko, K. J., Shril, S., Airik, M., JobstSchwan, T., Lovric, S., Braun, A. D., Heon Yung Gee, Schapiro, D., Majmundar. A., Sadowski, C. E., Pabst. W. L., Daga, A., van der Ven, T. A., Schmidt, M. J., Chuan Low, B., Gupta, B. A., Tripathi K. B., Wong, J., Campbell, K., Metcalfe, K., Schanze, D., Niihori, T., Kaito, H., Nozu, K., Tsukaguchi, H.,Tanaka, R., Hamahira, K., Kobayashi, K., Takizawa, T., Funayama, R., Nakayama, K., Aoki, Y., Kumaga N., Iijima, K., Fehrenbach, H., Kari, A. J., El Desoky, S., Jalalah, S., Bogdanovic, R., Stajić, N., Zappel, H., Rakhmetova, A., Wassmer, S., Jungraithmayr, T.,Strehlau, J., Aravind Selvin Kumar, Bagga, A., Soliman, A. N., Mane, M. S., Kaufman, L.,Lowy, R. D., Jairajpuri, A. M., Lifton, P. R., Pei, Y., Martin Zenker, M., Kure, S., Hildebrandt, F. Mutations in six nephrosis genes delineate a pathogenic pathway amenable to treatment. Nat Commun., 2018 May 17;9(1):1960. doi: 10.1038/s41467-018-04193-w
• Iwatani S, Shono A, Yoshida M, Yamana K, Thwin KKM, Kuroda J, Kurokawa D, Koda T, Nishida K, Ikuta T, Fujioka K, Mizobuchi M, Taniguchi-Ikeda M, Morioka I, Iijima K, Nishimura N. Involvement of WNT Signaling in the Regulation of Gestational Age-Dependent Umbilical Cord-Derived Mesenchymal Stem Cell Proliferation. Stem Cells Int. 2017;2017:8749751. doi: 10.1155/2017/8749751. Epub 2017 Sep 12.
• Mukohyama J, Shimono Y, Minami H, Kakeji Y, Suzuki A. Roles of microRNAs and RNA-binding proteins in the regulation of colorectal cancer stem cells. Cancers(Basel) 9(10); pii: E143, 2017. (doi: 10.3390/cancers9100143)
• Tatara T, Mukohara T, Tanaka R, Shimono Y, Funaoshi Y, Imamura Y, Toyoda M, Kiyota N, Hirai M, Kakeji Y, Minami H. 3D culture represents apoptosis induced by trastuzumab better than 2D monolayer culture. Anticancer Res 38: 2831-2839, 2018 (doi: 10.21873/anticanres.125278)
• Yoshikawa Y, Takano O, Kato I, Takahashi Y, Shima F, Kataoka T. Ras Inhibitors Display an Anti-Metastatic Effect by Downregulation of Lysyl Oxidase through Inhibition of the Ras-PI3K-Akt-HIF-1alpha Pathway. Cancer Letters. pii: S0304-3835(17)30567-0 2017.
• Shirafuji, T., Ueyama, T., Adachi, N., Yoshino, YK-I., Sotomaru, Y., Uwada, J., Kaneoka, A., Ueda, T., Tanaka, S.,Hide, I., Saito, N., Sakai, N. The role of cysteine string protein alpha (CSPα) phosphorylation at Serine 10, and 34, by protein kinase Cγ for presynaptic maintenance. J. Neurosci. 38 (2) 278-290 2017.
• (国)Hanes, CM., D’Amico, AE., Ueyama, T., Wong, AC., Zhang, X., Hynes, WF., Barroso, MM., Cady, NC., Trebak, M., Saito, N., Lennartz, MR. Golgi-associated PKC-ε is delivered to phagocytic cups: Role of PI4P J. Immunol. 199:271-277, 2017.
• Nakamura, T., Ueyama, T., Ninoyu, Y., Sakaguchi, H., Choijookhuu, N., Hishikawa, Y., Kiyonari, H., Kohta, M., Sakahara, M., de Curtis, I., Kohmura, E., Hisa, Y., Aiba, A., and Saito, N. Novel role of Rac-Mid1 signaling in medial cerebellar development. Development 144:1863-1875, (2017)

再生医学分野

• Daisuke Watanabe, Michiyo Koyanagi-Aoi, Mariko Taniguchi-Ikeda, Yukiko Yoshida , Takeshi Azuma, Takashi Aoi The Generation of Human γδT Cell-Derived Induced Pluripotent Stem Cells from Whole Peripheral Blood Mononuclear Cell Culture. Stem Cells Transl Med. 2017 Nov 21.
• Ryo Ishida, Michiyo Koyanagi-Aoi, Nobu Oshima, Yoshihiro Kakeji, Takashi Aoi The Tissue-Reconstructing Ability of Colon CSCs Is Enhanced by FK506 and Suppressed by GSK3 Inhibition. Mol Cancer Res. 2017 Oct; 15(10):1455-1466.
• Hiroyuki Ogawa, Michiyo Koyanagi-Aoi, Kyoko Otani, Yoh Zen, Yoshimasa Maniwa, Takashi Aoi Interleukin-6 blockade attenuates lung cancer tissue construction integrated by cancer stem cells Sci Rep. 2017 Sep 26; 7(1):12317.
• (国)Espinosa-Medina I, Jevans B, Boismoreau F, Chettouh Z, Enomoto H, Müller T, Birchmeier C, Burns AJ, Brunet JF. Dual origin of enteric neurons in vagal Schwann cell precursors and the sympathetic neural crest. Proc Natl Acad Sci U S A, 114(45): 11980-11985, 2017.
• Vassilev V, Platek A, Hiver S, Enomoto H, Takeichi M. Catenins Steer Cell Migration via Stabilization of Front-Rear Polarity. Dev Cell, S1534-5807(17) 30827-4, 2017
• Sotoyama H, Iwakura Y, Oda K, Sasaoka T, Takei N, Kakita A, Enomoto H, Nawa H. Striatal hypodopamine phenotypes found in transgenic mice that overexpress glial cell line-derived neurotrophic factor. Neurosci Lett, 27;654:99-106, 2017
• Nanno Y, Matsumoto I, Zen Y, Otani K, Uemura J, Toyama H, Asari S, Goto T, Ajiki T, Okano K, Suzuki Y, Takeyama Y, Fukumoto T, Ku Y. Pancreatic duct involvement in well-differentiated neuroendocrine tumors is an independent poor prognostic factor. Ann Surg Oncol. 2017; 24 (4):1127-1133
• Nanno Y, Toyama H, Matsumoto I, Otani K, Asari S, Goto T, Ajiki T, Zen Y, Fukumoto T, Ku Y. Baseline plasma chromogranin A levels in patients with well-differentiated neuroendocrine tumors of the pancreas: A potential predictor of postoperative recurrence. Pancreatology. 2017;17（2）:291-294
• Fukumoto T, Kido M, Takebe A, Tanaka M, Kinoshita H, Kuramitsu K, Komatsu S, Tsugawa D, Goto T, Asari S, Toyama H, Ajiki T, Ku Y. New macroscopic classification and back-flow thrombectomy for advanced hepatocellular carcinoma with portal vein tumor thrombus invading the contralateral second portal branch. Surg Today,2017;47(9):1094-1103