がん分野

• (国) Nishita, M., Nishio, T., Park, S-Y., Kamizaki, K., Wang, Z-C., Tamada, K., Takumi, T., Hashimoto, R., Otani, H., Pazour, G. J., Hsu, V. W., Minami, Y.
  Ror2 signaling regulates Golgi structure through IFT20 for tumor invasiveness.
  Scientific Rep. 7: 1, 2017. doi: 10.1038/s41598-016-0028-x.
• Endo, M., Ubulkasim, G., Kobayashi, C., Onishi, R., Minami, Y.
  Critical role of Ror2 receptor tyrosine kinase in regulating cell cycle progression of reactive astrocytes following brain injury.
  Glia65: 182-197, 2017. doi: 10.1002/glia.23086.
• Wakita M, Edamatsu H, Li M, Emi A, Kitazawa S, Kataoka T
  Phospholipase Cε activates nuclear factor-κB signaling by causing cytoplasmic localization of ribosomal S6 kinase and facilitating its phosphorylation of inhibitor κB in colon epithelial cells.
  J Biol Chem291 (24): 12586-12600, 2016. doi: 10.1074/jbc.M116.717561
• (国)Yanagita T, Murata Y, Tanaka D, Motegi SI, Arai E, Daniwijaya EW, Hazama D, Washio K, Saito Y, Kotani T, Ohnishi H, Oldenborg PA, Garcia NV, Miyasaka M, Ishikawa O, Kanai Y, Komori T, Matozaki T
  Anti-SIRPα antibodies as a potential new tool for cancer immunotherapy.
  JCI Insight2(1): 89140-89140,2017. doi: 10.1172/jci.insight.89140.
• Imada S, Murata Y, Kotani T, Hatano M, Sun C, Konno T, Park JH, Kitamura Y, Saito Y, Ohdan H, Matozaki T
  Role of Src family kinases in regulation of intestinal epithelial homeostasis.
  Mol Cell Biol36(22): 2811-2823,2016. doi:10.1128/MCB.00311-16.
• Hashimoto O, Yoshida M, Koma Y, Yanai T, Hasegawa D, Kosaka Y, Nishimura N, Yokozaki H
  Collaboration of cancer-associated fibroblasts and tumour-associated macrophages for neuroblastoma development
  J Pathol 240(2):211-23, 2016. doi: 10.1002/path.4769
• (国)Yang YR, Jung JH, Kim SJ, Hamada K, Suzuki A, Kim HJ, Lee JH, Kwon OB, Lee YK, Kim J, Kim EK, Jang HJ, Kang DS, Choi JS, Lee CJ, Marshall J, Koh HY, Kim CJ, Seok H, Kim SH, Choi JH, Choi YB, Cocco L, Ryu SH, Kim JH, Suh PG
  Forebrain-specific ablation of phospholipase Cγ１ causes manic-like behavior.
  Mol Psychiatry,2017 Oct;22(10):1473-1482. doi: 10.1038/mp.2016.261. Epub 2017 Jan 31
• Okada Y, Sonoshita M, Kakizaki F, Aoyama N, Itatani Y, Uegaki M, Sakamoto H, Kobayashi T, Inoue T, Kamba T, Suzuki A, Ogawa O, Taketo MM
  Amino-terminal enhancer of split gene AES encodes a tumor and metastasis suppressor of prostate cancer.
  Cancer Sci2017 Apr;108(4):744-752. doi: 10.1111/cas.13187. Epub 2017 Apr 12

代謝分野

• Tamori Y, Tateya S, Ijuin T, Nishimoto Y, Nakajima S, Ogawa W.
  Negatively-charged residues in the polar carboxy-terminal region in FSP27 are indispensable for expanding lipid droplets.
  FEBS Lett.;590(6):750-9. 2016 doi: 10.1002/1873-3468.12114
• Nishizawa H, Iguchi G, Fukuoka H, Takahashi M, Suda K, Bando H, Matsumoto R, Yoshida K, Odake Y, Ogawa W, Takahashi Y
  IGF-I induces senescence of hepatic stellate cells and limits fibrosis in a p53-dependent manner.
  Sci Rep.6, 34605 2016 ; doi: 10.1038/srep34605
• Kasahara K, Tanoue T, Yamashita T, Yodoi K, Matsumoto T, Emoto T, Mizoguchi T, Hayashi T, Kitano N, Sasaki N, Atarashi K, Honda K, Hirata KI
  Commensal bacteria at the crossroad between cholesterol homeostasis and chronic inflammation in atherosclerosis.
  J Lipid Res 58(3):519-528,2017 doi: 10.1194/jlr.M072165.
• (国)Liu X, Uemura A, Fukushima Y, Yoshida Y, Hirashima M
  Semaphorin 3G provides a repulsive guidance cue to lymphatic endothelial cells via Neuropilin-2/PlexinD1.
  Cell Rep 17(9):2299-2311, 2016. doi: 10.1016/j.celrep.2016.11.008.
• (国) Otowa Y, Moriwaki K, Sano K, Shirakabe M, Yonemura S, Shibuya M, Rossant J, Suda T, Kakeji Y, Hirashima M
  Flt1/VEGFR1 heterozygosity causes transient embryonic edema.
  Sci Rep6:27186, 2016. doi: 10.1038/srep27186.
• Sakai M, Tujimura-Hayakawa T, Yagi T, Yano H, Mitsushima M, Unoki-Kubota H, Kaburagi Y, Inoue H, Kido Y, Kasuga M, Matsumoto M
  The GCN5-CITED2-PKA signalling module controls hepatic glucose metabolism through a cAMP-induced substrate switch.
  Nat Commun7: 13147-13147,2016. doi: 10.1038/ncomms13147.

脳・こころ分野

• Manya H, Yamaguchi Y, Kanagawa M, Kobayashi K, Tajiri M, Akasaka-Manya K, Kawakami H, Mizuno M, Wada Y, Toda T, Endo T
  The Muscular Dystrophy Gene TMEM5 Encodes a Ribitol β1,4-Xylosyltransferase Required for the Functional Glycosylation of Dystroglycan.
  J Biol Chem291(47): 24618- 24627,2016. Epub 2016 Oct 12.
• O Hare M, Shadmand M, Sulaiman RS, Sishtla K, Sakisaka T, Corson TW
  Kif14 overexpression accelerates murine retinoblastoma development.
  Int J Cancer139(8): 1752-8, 2016 doi: 10.1002/ijc.30221.
• Deguchi Y, Harada M, Shinohara R, Lazarus M, Cherasse Y, Urade Y, Yamada D, Sekiguchi M, Watanabe D, Furuyashiki T, Narumiya S
  mDia and ROCK Mediate Actin-Dependent Presynaptic Remodeling Regulating Synaptic Efficacy and Anxiety
  Cell Rep17(9):2405-2417, 2016. doi: 10.1016/j.celrep.2016.10.088.
• Kawano Y, Fukui C, Shinohara M, Wakahashi K, Ishii S, Suzuki T, Sato M, Asada N, Kawano H, Minagawa K, Sada A, Furuyashiki T, Uematsu S, Akira S, Uede T, Narumiya S, Matsui T, Katayama Y
  G-CSF-induced sympathetic tone provokes fever and primes antimobilizing functions of neutrophils via PGE2.
  Blood129(5):587-597,2017. Doi: 10.1182/blood-2016-07-725754

免疫・炎症分野

• (国)Milbradt J, Hutterer C, Bahsi H, Wagner S, Sonntag E, Horn AH, Kaufer BB, Mori Y, Sticht H, Fossen T, Marschall M
  The Prolyl Isomerase Pin1 Promotes the Herpesvirus-Induced Phosphorylation-Dependent Disassembly of the Nuclear Lamina Required for Nucleocytoplasmic Egress.
  PLoS Pathog12(8): e1005825- e1005825,2016. doi: 10.1371/journal.ppat.1005825.
• Wang B, Nishimura M, Tang H, Kawabata A, Mahmoud NF, Khanlari Z, Hamada D, Tsuruta H, Mori Y
  Crystal Structure of Human Herpesvirus 6B Tegument Protein U14.
  PLoS Pathog.;12(5):e1005594, 2016 May 6. doi: 10.1371/journal.ppat.1005594. eCollection 2016 May
• Kawaguchi Y, Taoka M, Takekiyo T, Uekita T, Shoji I, Hachiya N, Ichimura T
  TRIM32-Cytoplasmic-Body Formation Is an ATP-Consuming Process Stimulated by HSP70 in Cells.
  PLoS One12(1): e0169436- e0169436, 2017. doi: 10.1371/journal.pone.0169436.
• Aizawa S, Okamoto T, Sugiyama Y, Kouwaki T, Ito A, Suzuki T, Ono C, Fukuhara T, Yamamoto M, Okochi M, Hiraga N, Imamura M, Chayama K, Suzuki R, Shoji I, Moriishi K, Moriya K, Koike K, and Matsuura Y.
  TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis.
  Nature Communications, 7: 11379, 2016. doi: 10.1038/ncomms11379.
• Kimura Y, Shimada-Omori R, Takahashi T, Tsuchiyama K, Kusakari Y, Yamasaki K, Nishikawa R, Nishigori C, Aiba S
  Therapeutic drug monitoring of patients with psoriasis during tumour necrosis factor (TNF)-α antagonist treatment using a novel interleukin-8 reporter cell line
  Br J Dermatol175(5):979-987,2016. doi: 10.1111/bjd.14717
• Okano T, Saegusa J, Nishimura K, Takahashi S, Sendo S, Ueda Y, Morinobu A
  3-bromopyruvate ameliorate autoimmune arthritis by modulating Th17/Treg cell differentiation and suppressing dendritic cell activation
  Sci Rep7: 42412-42412,2017. doi: 10.1038/srep42412.
• Inoue M, Oyama D, Hidaka K, Kameoka M
  Evaluation of novel protease inhibitors against darunavir-resistant variants of HIV type 1
  FEBS Open Bio7(1):88-95,2016. doi:10.1002/2211-5463.12160.

創薬分野

• (国)Nozu K, Iijima K, Igarashi T, Yamada S, Kralovicova J, Nozu Y, Yamamura T, Minamikawa S, Morioka I, Ninchoji T, Kaito H, Nakanishi K, Vorechovsky I.
  A birth of bipartite exon by intragenic deletion.
  Mol Genet Genomic Med5(3):287-94, 2017 doi: 10.1002/mgg3.277.
• Kamiyoshi N, Nozu K, Fu XJ, Morisada N, Nozu Y, Ye MJ, Imafuku A, Miura K,　Yamamura T, Minamikawa S, Shono A, Ninchoji T, Morioka I, Nakanishi K, Yoshikawa N, Kaito H, Iijima K.
  Genetic, Clinical, and Pathologic Backgrounds of Patients with Autosomal Dominant Alport Syndrome.
  Clin J Am Soc Nephrol11(8):1441-9, 2016 doi: 10.2215/CJN.01000116
• Nishimura M, Toyoda M, Takenaka K, Imamura Y, Chayahara N, Kiyota N, Mukohara T, Kotake T, Tsuji A, Saito K, Saito Y, Minami H
  The combination of HLA-B*15:01 and DRB1*15:01 is associated with gemcitabine plus erlotinib-induced interstitial lung disease in patients with advanced pancreatic cancer.
  Cancer Chemother Pharmacol 77(6): 1165-70,2016 doi: 10.1007/s00280-016-3026-6. Epub 2016 Apr 21
• (国)Okada T, Lee AY, Qin LX, Agaram N, Mimae T, Shen Y, O’Connor R, Lopez-Lago MA, Craig A, Miller ML, Agius P, Molinelli E, Socci ND, Crago AM, Shima F, Sander C, Singer S
  Integrin-α10 Dependency Identifies RAC and RICTOR as Therapeutic Targets in High-Grade Myxofibrosarcoma
  Cancer Discov 6(10):1148-1165,2016.
• Matsumoto S, Miyano N, Baba S, Liao J, Kawamura T, Tsuda C, Takeda A, Yamamoto M, Kumasaka T, Kataoka T, Shima F
  Molecular Mechanism for Conformational Dynamics of Ras·GTP Elucidated from In-Situ Structural Transition in Crystal.
  Sci Rep16(6):25931-25931,2016. doi: 10.1038/srep25931.
• (国)Ishii T, Ueyama T, Shigyo M, Kohta M, Kondoh T, Kuboyama T, Uebi T, Hamada T, Gutmann DH, Aiba A, Kohmura E, Tohda C, Saito N
  A Novel Rac1-GSPT1 Signaling Pathway Controls Astrogliosis Following Central Nervous System Injury.
  J Biol Chem292(4): 1240-1250,2017. doi:10.1074/jbc.M116.748871.

再生医学分野

• Arai K, Fukumoto T, Kido M, Tanaka M, Kuramitsu K, Kinoshita H, Komatsu S, Tsugawa D, Terai S, Matsumoto T, Goto T, Asari S, Toyama H, Ajiki T, Ku Y
  Preoperative neutrophil-to-lymphocyte ratio as a predictor of survival after reductive surgery plus percutaneous isolated hepatic perfusion for hepatocellular carcinoma: a retrospective analysis　
  Surg Today47(3):358-392, 2017. doi:10.1007/s00595-016-1384-7
• Akahane S, Sakai Y, Ueha T, Nishimoto H, Inoue M, Niikura T, Kuroda R
  Transcutaneous carbon dioxide application accelerates muscle injury repair in rat models
  Int Orthop 2017 May;41(5):1007-1015. doi: 10.1007/s00264-017-3417-2.
• Kihara S, Hayashi S, Hashimoto S, Kanzaki N, Takayama K, Matsumoto T, Chinzei N, Iwasa K, Haneda M, Takeuchi K, Nishida K, Kuroda R
  Cyclin-Dependent Kinase Inhibitor-1-Deficient Mice Are Susceptible to Osteoarthritis Associated With Enhanced Inflammation.
  J Bone Miner Res, 2017 May;32(5):991-1001. doi: 10.1002/jbmr.3080.