がん分野

• Hiroki Sakamoto, Yu-ichiro Koma, Nobuhide Higashino, Takayuki Kodama, Kohei Tanigawa, Masaki Shimizu, Masataka Fujikawa, Mari Nishio, Manabu Shigeoka, Yoshihiro Kakeji, Hiroshi Yokozaki.PAI-1 derived from cancer-associated fibroblasts in esophageal squamous cell carcinoma promotes the invasion of cancer cells and the migration of macrophages. Laboratory Investigation,101(3):353-368,202103
• Shihori Tanabe, Sabina Quader, Ryuichi Ono, Horacio Cabral, Kazuhiko Aoyagi, Akihiko Hirose, Hiroshi Yokozaki Y, Hiroki Sasaki Molecular Network Profiling in Intestinal- and Diffuse-Type Gastric Cancer.Cancers, 12(12):3833-3833
• Takayuki Kodama, Yu-ichiro Koma, Noriaki Arai, Aya Kido, Naoki Urakawa, Mari Nishio, Manabu Shigeoka, Hiroshi Yokozaki CCL3–CCR5 axis contributes to progression of esophageal squamous cell carcinoma by promoting cell migration and invasion via Akt and ERK pathways. Laboratory Investigation,100(9):1140-1157,20200526
• (国)Tomohiko Maehama, Miki Nishio, Junji Otani, Tak Wah Mak, Akira Suzuki The role of Hippo‐YAP signaling in squamous cell carcinomas. Cancer Science,112(1):51-60,202101
• (国)Miki Nishio, Yoko To, Tomohiko Maehama, Yukari Aono, Junji Otani, Hiroki Hikasa, Akihiro Kitagawa, Koshi Mimori, Takehiko Sasaki, Hiroshi Nishina, Shinya Toyokuni, John P. Lydon, Kazuwa Nakao, Tak Wah Mak, Tohru Kiyono, Hidetaka Katabuchi, Hironori Tashiro, Akira Suzuki Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice. Cancer Science,111(10):3576-3587,202010
• (国)Takako Ooshio, Masahiro Yamamoto, Kiyonaga Fujii, Bing Xin, Kenji Watanabe, Masanori Goto, Yoko Okada, Akira Suzukii, Josef M. Penninger, Hiroshi Nishina, Yuji Nishikawa Hepatocyte MKK7 Contributes to Restoration of the Liver Parenchyma Following Injury. Hepatology, 20200923
• Koki Kamizaki, Mitsuharu Endo, Yasuhiro Minamii, Yasuhiro Kobayashi Role of noncanonical Wnt ligands and Ror-family receptor tyrosine kinases in the development, regeneration, and diseases of the musculoskeletal system. Dev Dyn. 2021 ;250(1):27-38
• (国)Misuzu Hashimoto, Ayako Kumabe, Jun-Dal Kim, Kazuya Murata, Sowmya Sekizar, Anna Williams, Weizhe Lu, Junji Ishida, Tsutomu Nakagawa, Mitsuharu Endo, Yasuhiro Minamii, Akiyoshi Fukamizu Loss of PRMT1 in the central nervous system (CNS) induces reactive astrocytes and microglia during postnatal brain development. J Neurochem 2021 ;156(6):834-847.
• Taro Ikeda, Michiru Nishita, Kyoka Hoshi, Takashi Honda, Yoshihiro Kakeji,Yasuhiro MinamiMesenchymal stem cell-derived CXCL16 promotes progression of gastric cancer cells by STAT3-mediated expression of Ror1.Cancer Sci. 2020 ;111(4):1254-1265.
• Takashi Matozaki, Takenori Kotani, Yoji Murata, Yasuyuki Saito Roles of Src family kinase, Ras, and mTOR signaling in intestinal epithelial homeostasis and tumorigenesis. Cancer Sci. 2021 ;112(1):16-21.
• Taichi Nishimura, Yasuyuki Saito, Ken Washio, Satomi Komori, Datu Respatika, Takenori Kotani, Yoji Murata, Hiroshi Ohnishi, Satoshi Mizobuchi, Takashi Matozaki  i SIRPα on CD11c+ cells induces Th17 cell differentiation and subsequent inflammation in the CNS in experimental autoimmune encephalomyelitis.Eur J Immunol. 2020 ;50(10):1560-1570.
• Daisuke Hazama, Yizhen Yin, Yoji Murata, Makoto Matsuda, Takeshi Okamoto, Daisuke Tanaka, Naohiro Terasaka, Jinxuan Zhao, Mariko Sakamoto, Yuka Kakuchi, Yasuyuki Saito, Takenori Kotani, Yoshihiro Nishimura, Atsushi Nakagawa, Hiroaki Suga,Takashi Matozaki Macrocyclic Peptide-Mediated Blockade of the CD47-SIRPα Interaction as a Potential Cancer Immunotherapy. Cell Chem Biol. 2020 ;27(9):1181-1191.
• Naoki Shibuya, Yoshihiro Kakeji, Yohei Shimono MicroRNA-93 targets WASF3 and functions as a metastasis suppressor in breast cancer. Cancer Sci. 2020 ;111(6):2093-2103.
• Imen Jebri, Kazuya Tsujita, Yasuyuki Fujita, Toshiki Itoh Non-cell-autonomous migration of RasV12-transformed cells towards the basal side of surrounding normal cells. Biochem Biophys Res Commun. 2021;5;543:15-22.

代謝分野

• Yoshiro Tsukiyama, Akihide Konishi, Toshiro Shinke, Amane Kozuki, Hiromasa Otake, Hiroyuki Kawamori, Kenichi Yanaka, Osamu Iida, Takayuki Ishihara, Takumi Inoue, Masamichi Iwasaki, Makoto Kadotani, Naoki Matsukawa, Keiji Noutomi, Yasumasa Kakei, Isao Nanba, Takashi Omori, Junya Shite, Ken-Ichi Hirata Open-label multicenter registry on the outcomes of peripheral arterial disease treated by balloon angioplasty with optical frequency domain imaging in superficial femoral artery and popliteal artery (OCEAN-SFA study). Biochem Biophys Res Commun. 2021 ; 5;543:15-22.
• Mitsumasa Okano, Tetsuya Hara, Makoto Nishimori, Yasuhiro Irino, Seimi Satomi-Kobayashi, Masakazu Shinohara, Ryuji Toh, Farouc A Jaffer, Tatsuro Ishida, Ken-Ichi Hirata In Vivo Imaging of Venous Thrombus and Pulmonary Embolism Using Novel Murine Venous Thromboembolism Model. JACC Basic Transl Sci. 2020 ;5(4):344-356.
• Barinda AJ, Ikeda K, Nugroho DB, Wardhana DA, Sasaki N, Honda S, Urata R, Matoba S, Hirata KI, Emoto N. Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype. Nat Commun. 2020 ;11(1):481.
• Ayumi Kanno, Shun-Ichiro Asahara, Ayuko Furubayashi, Katsuhisa Masuda, Risa Yoshitomi, Emi Suzuki, Tomoko Takai, Maki Kimura-Koyanagi, Tomokazu Matsuda, Alberto Bartolome, Yushi Hirota, Norihide Yokoi, Yuka Inaba, Hiroshi Inoue, Michihiro Matsumoto, Kenichi Inoue, Takaya Abe, Fan-Yan Wei, Kazuhito Tomizawa, Wataru Ogawa Susumu Seino, Masato Kasuga, Yoshiaki Kido GCN2 regulates pancreatic β cell mass by sensing intracellular amino acid levels. JCI Insight. 2020 ;5(9):e128820

脳こころ分野

• Yasuhisa Ano, Shiho Kitaoka, Rena Ohya, Keiji Kondo, Tomoyuki Furuyashiki Hop Bitter Acids Increase Hippocampal Dopaminergic Activity in a Mouse Model of Social Defeat Stress. Int J Mol Sci. 2020 ;21(24):9612.
• Yuka Ishikawa, Shiho Kitaoka, Yuko Kawano, Shinichi Ishii, Tomohide Suzuki, Kanako Wakahashi, Taro Kato, Yoshio Katayama, Tomoyuki Furuyashiki Repeated social defeat stress induces neutrophil mobilization in mice: maintenance after cessation of stress and strain-dependent difference in response. Br J Pharmacol. 2021 ;178(4):827-844.
• Midori Nagai, Hirotaka Nagai, Chisato Numa, Tomoyuki Furuyashiki Stress-induced sleep-like inactivity modulates stress susceptibility. Scientific Reports,13 November,2020.
• Naohiko Seike, Akio Yokoseki, Ryoko Takeuchi, Kento Saito, Hiroaki Miyahara, Akinori Miyashita, Tetsuhiko Ikeda, Izumi Aida, Takashi Nakajima, Masato Kanazawa, Masatoshi Wakabayashi, Yasuko Toyoshima, Hitoshi Takahashi, Riki Matsumoto, Tatsushi Toda, Osamu Onodera, Atsushi Ishikawa, Takeshi Ikeuchi, Akiyoshi Kakita Genetic Variations and Neuropathologic Features of Patients with PRKN Mutations. Movement Disorders, 2021
• Mitsuyoshi Nakatani, Riki Matsumoto, Katsuya Kobayashi, Takefumi Hitomi, Morito Inouchi, Masao Matsuhashi, Masako Kinoshita, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Susumu Miyamoto, Ryosuke Takahashi, Nobutaka Hattori, Akio Ikeda Electrical cortical stimulations modulate spike and post-spike slow-related high-frequency activities in human epileptic foci. Clin Neurophysiol, 2020 ;131(8):1741-1754.
• (国)Takuro Nakae, Riki Matsumoto, Takeharu Kunieda, Yoshiki Arakawa, Katsuya Kobayashi, Akihiro Shimotake, Yukihiro Yamao, Takayuki Kikuchi, Toshihiko Aso, Masao Matsuhashi, Kazumichi Yoshida, Akio Ikeda, Ryosuke Takahashi, Matthew A Lambon Ralph, Susumu Miyamoto Connectivity Gradient in the Human Left Inferior Frontal Gyrus: Intraoperative Cortico-Cortical Evoked Potential Study. Cereb Cortex, 2020 ;30(8):4633-4650.
• Yasunori Uchida, Yasunori Yamamoto, Toshiaki Sakisaka Trans-2-enoyl-CoA reductase limits Ca²⁺ accumulation in the endoplasmic reticulum by inhibiting the Ca²⁺ pump SERCA2b. Journal of Biological Chemistry296,January-June 2021
• Nobuhiro Nakai, Eric T N Overton, Toru Takumi Optogenetic Approaches to Understand the Neural Circuit Mechanism of Social Deficits Seen in Autism Spectrum Disorders. Adv Exp Med Biol, 2021 ;1293:523-533.
• Janak R Awasthi, Kota Tamada, Eric T N Overton, Toru Takumi Comprehensive topographical map of the serotonergic fibers in the male mouse brain. J Comp Neurol, 2021 ;529(7):1391-1429.
• Isamu Miura, Masaaki Sato, Eric T N Overton, Nobuo Kunori, Junichi Nakai, Takakazu Kawamata, Nobuhiro Nakai, Toru Takumi Encoding of social exploration by neural ensembles in the insular cortex. PLoS Biol, 2020 ;18(9):e3000584.

免疫・炎症分野

• Ken Okamura, Yuko Abe, Izumi Naka, Jun Ohashi, Akiko Yagami, Kayoko Matsunaga, Yui Kobayashi, Kazuyoshi Fukai, Atsushi Tanemura, Ichiro Katayama, Yukiko Masui, Akiko Ito, Toshiharu Yamashita, Hiroshi Nagai, Chikako Nishigori, Naoki Oiso, Yumi Aoyama, Yuta Araki, Toru Saito, Masahiro Hayashi, Yutaka Hozumi, Tamio Suzuki Genome-wide association study identifies CDH13 as a susceptibility gene for rhododendrol-induced leukoderma. Pigment Cell Melanoma Res,2020 ;33(6):826-833.
• Yoshiko Oda, Ken Washio, Atsushi Fukunaga, Shinya Imamura, Mayumi Hatakeyama, Kanako Ogura, Kaori Ishii, Michihiro Hide, Chikako Nishigori  Clinical utility of the basophil activation test in the diagnosis of sweat allergy. Allergol Int, 2020 ;69(2):261-267.
• Tomoaki Matsumori, Yuzo Kodama, Atsushi Takai, Masahiro Shiokawa, Yoshihiro Nishikawa, Tomonori Matsumoto, Haruhiko Takeda, Saiko Marui, Hirokazu Okada, Tomonori Hirano, Takeshi Kuwada, Yuko Sogabe, Nobuyuki Kakiuchi, Teruko Tomono, Atsushi Mima, Toshihiro Morita, Tatsuki Ueda, Motoyuki Tsuda, Yuki Yamauchi, Katsutoshi Kuriyama, Yojiro Sakuma, Yuji Ota, Takahisa Maruno, Norimitsu Uza, Hiroyuki Marusawa, Ryoichiro Kageyama, Tsutomu Chiba, Hiroshi Seno Hes1 Is Essential in Proliferating Ductal Cell-Mediated Development of Intrahepatic Cholangiocarcinoma. Cancer Res, 2020 ;80(23):5305-5316.
• Toshihiro Morita, Yuzo Kodama, Masahiro Shiokawa, Katsutoshi Kuriyama, Saiko Marui, Takeshi Kuwada, Yuko Sogabe, Tomoaki Matsumori, Nobuyuki Kakiuchi, Teruko Tomono, Atsushi Mima, Tatsuki Ueda, Motoyuki Tsuda, Yuki Yamauchi, Yoshihiro Nishikawa, Yojiro Sakuma, Yuji Ota, Takahisa Maruno, Norimitsu Uza, Takashi Nagasawa, Tsutomu Chiba, Hiroshi Seno CXCR4 in Tumor Epithelial Cells Mediates Desmoplastic Reaction in Pancreatic Ductal Adenocarcinoma. Cancer Res, 2020 ;80(19):4058-4070
• Yu Sato, Takashi Kobayashi, Shin Nishiumi, Akihiko Okada, Tsuyoshi Fujita, Tsuyoshi Sanuki, Masao Kobayashi, Masakyo Asahara, Masayasu Adachi, Arata Sakai, Hideyuki Shiomi, Atsuhiro Masuda, Masaru Yoshida, Keiko Takeuchi, Yuzo Kodama, Hiromu Kutsumi, Kengo Nagashima, Kazufumi Honda Prospective Study Using Plasma Apolipoprotein A2-Isoforms to Screen for High-Risk Status of Pancreatic Cancer. Cancers (Basel), 2020 ;12(9):2625.
• Lidya Handayani Tjan, Koichi Furukawa, Tatsuya Nagano, Tatsunori Kiriu, Mitsuhiro Nishimura, Jun Arii, Yasuhisa Hino, Sachiyo Iwata, Yoshihiro Nishimura, Yasuko Mori Early differences in cytokine production distinguish severity of COVID-19. J Infect Dis, 2021 ;223(7):1145-1149.
• (国)Mitsuhiro Nishimura, Bernadette Dian Novita, Takayuki Kato, Lidya Handayani Tjan, Bochao Wang, Aika Wakata, Anna Lystia Poetranto, Akiko Kawabata, Huamin Tang, Taiki Aoshi, Yasuko Mori Structural basis for the interaction of human herpesvirus 6B tetrameric glycoprotein complex with the cellular receptor, human CD134. PLoS Pathog, 2020 ;16(7):e1008648.
• Bochao Wang, Kouichi Hara, Akiko Kawabata, Mitsuhiro Nishimura, Aika Wakata, Lidya Handayani Tjan, Anna Lystia Poetranto, Chisato Yamamoto, Yasunari Haseda, Taiki Aoshi, Lisa Munakata, Ryo Suzuki, Masato Komatsu, Ryuko Tsukamoto, Tomoo Itoh, Chikako Nishigori, Yasuyuki Saito, Takashi Matozaki, Yasuko Mori Tetrameric glycoprotein complex gH/gL/gQ1/gQ2 is a promising vaccine candidate for human herpesvirus 6B. PLoS Pathog, 2020 ;16(7):e1008609.
• (国)Takako Utsumi, Maria Inge Lusida, Zayyin Dinana, Rury Mega Wahyuni, Soegeng Soegijanto, Soetjipto, Alpha Fardah Athiyyah, Subijanto Marto Sudarmo, Reza Gunadi Ranuh, Andy Darma, Juniastuti, Laura Navika Yamani, Yen Hai Doan, Hiroyuki Shimizu, Koji Ishii, Chieko Matsui, Lin Deng, Takayuki Abe, Kazuhiko Katayama, Ikuo Shoji Molecular epidemiology and genetic diversity of norovirus infection in children hospitalized with acute gastroenteritis in East Java, Indonesia in 2015-2019. Infect Genet Evol, 2021 88:104703.
• (国)Takayuki Abe, Nanae Minami, Rheza Gandi Bawono, Chieko Matsui, Lin Deng, Takasuke Fukuhara, Yoshiharu Matsuura, Ikuo Shoji ISGylation of hepatitis C virus NS5A protein promotes viral RNA replication via the recruitment of cyclophilin A. J Virol, 2020 ;94(20):e00532-20
• (国)Takako Utsumi, Rury M Wahyuni, Zayyin Dinana, Emily Gunawan, Arga S D Putra, Teguh Mubawadi, Soetjipto, Maria I Lusida, Ikuo Shoji G2P[4] rotavirus outbreak in Belu, East Nusa Tenggara Province, Indonesia, 2018. J Infect Public Health, 2020 13(10):1592-1594.
• (国)Kotaki T, Xie X, Shi PY, Kameoka M A PCR amplicon–based SARS-CoV-2 replicon for antiviral evaluation. Sci Rep, 2021 ;11(1):2229.
• Ophinni Y, Miki S, Hayashi Y, Kameoka M Multiplexed tat-targeting CRISPR-Cas9 protects T cells from acute HIV-1 infection with inhibition of viral escape. Viruses, 2020 ;12(11):1223
• (国)Khairunisa SQ, Megasari NLA, Ueda S, Budiman W, Kotaki T, Nasronudin, Kameoka M 2018-2019 Update on the Molecular Epidemiology of HIV-1 in Indonesia. AIDS Res Hum Retroviruses, 2020 36(11):957-963.

創薬・医療機器分野

• Masayuki Akita, Ryuichiro Sawada, Masato Komatsu, Nadia Suleman, Tomoo Itoh, Tetsuo Ajiki, Nigel Heaton, Takumi Fukumoto, Yoh Zen An immunostaining panel of C-reactive protein, N-cadherin, and S100 calcium binding protein P is useful for intrahepatic cholangiocarcinoma subtyping. Hum Pathol, 2021 ;109:45-52.
• Hirochika Toyama, Ippei Matsumoto, Takuya Mizumoto, Hirofumi Fujita, Shinobu Tsuchida, Yoshihiro Kanbara, Yoshihiko Kadowaki, Hiromi Maeda, Keiichi Okano, Masato Fukuoka, Shiro Takase, Sachiyo Shirakawa, Sachio Terai, Hideyo Mukubo, Jun Ishida, Hironori Yamashita, Kimihiko Ueno, Motofumi Tanaka, Masahiro Kido, Tetsuo Ajiki, Sae Murakami, Kunihiro Nishimura, Takumi Fukumoto Influence of the Retrocolic Versus Antecolic Route for Alimentary Tract Reconstruction on Delayed Gastric Emptying After Pancreatoduodenectomy: A Multicenter, Noninferiority Randomized Controlled Trial. Ann Surg, 2021 ;274(6):935-944.
• Ryuichi Yada, Kazusuke Maenaka, Shuji Miyamoto, Go Okada, Aki Sasakura, Motoi Ashida, Masashi Adachi, Tatsuhiko Sato, Tianyuan Wang, Hiroaki Akasaka, Naritoshi Mukumoto, Yasuyuki Shimizu, Ryohei Sasaki　Real-time　in vivo　dosimetry system based on an optical fiber-coupled microsized photostimulable phosphor for stereotactic body radiation therapy. Med Phys, 2020 ;47(10):5235-5249.
• SACHIKO INUBUSHI, HIROKI KAWAGUCHI, SACHIKO MIZUMOTO, TOMONARI KUNIHISA, MOTOI BABA, YUKIYA KITAYAMA, TOSHIFUMI TAKEUCHI, ROBERT M. HOFFMAN, RYOHEI SASAKI Oncogenic miRNAs Identified in Tear Exosomes from Metastatic Breast Cancer Patients. Anticancer Res. 2020 Jun;40(6):3091-3096
• Toshifumi Takeuchi, Kisho Mori, Hirobumi Sunayama, Eri Takano, Yukiya Kitayama, Taku Shimizu, Yuzuki Hirose, Sachiko Inubushi, Ryohei Sasaki, Hirokazu Tanino Antibody-Conjugated Signaling Nanocavities Fabricated by Dynamic Molding for Detecting Cancers Using Small Extracellular Vesicle Markers from Tears. J Am Chem Soc. 2020 ;142(14):6617-6624.
• Hironobu Minami, Toshihiko Doi, Masanori Toyoda, Yoshinori Imamura, Naomi Kiyota, Ayako Mitsuma, Tomoya Shimokata, Yoichi Naito, Nobuaki Matsubara, Takeshi Tajima, Kota Tokushige, Kae Ishihara, Scott Cameron, Yuichi Ando Phase I study of the antiprogrammed cell death-1 Ab spartalizumab (PDR001) in Japanese patients with advanced malignancies. Cancer Sci.2021 Feb;112(2):725-733
• Hidetoshi Hayashi, Yuichi Takiguchi, Hironobu Minami, Kohei Akiyoshi, Yoshihiko Segawa, Hiroki Ueda, Yasuo Iwamoto, Chihiro Kondoh, Koji Matsumoto, Shin Takahashi, Hisateru Yasui, Toshiyuki Sawa, Yusuke Onozawa, Yasutaka Chiba, Yosuke Togashi, Yoshihiko Fujita, Kazuko Sakai, Shuta Tomida, Kazuto Nishio, Kazuhiko Nakagawa Site-Specific and Targeted Therapy Based on Molecular Profiling by Next-Generation Sequencing for Cancer of Unknown Primary Site. JAMA Oncol.2020 Dec 1;6(12):1931-1938
• HIRONOBU MINAMI, YUICHI ANDO, KENJI TAMURA, TAKESHI TAJIMA, RANDI ISAACS Phase I Study of LFA102 in Patients with Advanced Breast Cancer or Castration-resistant Prostate Cancer. Anticancer Res.2020 Sep,40(9:5229-5235.
• Shigeyuki Matsumoto, Haruka Taniguchi-Tamura, Mitsugu Araki, Takashi Kawamura, Ryo Miyamoto, Chiemi Tsuda, Fumi Shima, Takashi Kumasaka, Yasushi Okuno, Tohru Kataoka Oncogenic mutations Q61L and Q61H confer active form-like structural features to the inactive state (state 1) conformation of H-Ras protein. Biochem Biophys Res Commun. 2021 Aug 6;565:85-90.
• Takamitsu Inoue, Masayoshi Miura, Masaaki Yanishi, Junya Furukawa, Fuminori Sato, Masahiro Nitta, Koji Yoshimura, Jun Hagiuda, Kazunobu Shinoda, Takashi Kobayashi, Akira Miyajima, Ken Nakagawa, Mototsugu Oya, Osamu Ogawa, Hiromitsu Mimata, Hiro-Omi Kanayama, Masato Fujisawa, Toshiro Terachi, Tadashi Matsuda, Tomonori Habuchi A comparison of laparoendoscopic single-site surgery versus conventional procedures for laparoscopic donor nephrectomy: a Japanese multi-institutional retrospective study. Surg Endosc. 2020 Aug;34(8)3424-3434.
• Kentaro Suda, Hidenori Fukuoka, Yuto Yamazaki, Katsumi Shigemura, Miki Mukai, Yukiko Odake, Ryusaku Matsumoto, Hironori Bando, Michiko Takahashi, Genzo Iguchi, Masato Fujisawa, Masahiro Oka, Katsuhiko Ono, Kazuo Chihara, Hironobu Sasano, Wataru Ogawa, Yutaka Takahashi Cardiac myxoma caused by fumarate hydratase gene deletion in patient with cortisol-secreting adrenocortical adenoma. J Clin Endocrinol Metab.2020 Jun 1;105(6):dgaa163.
• Kotaro Suzuki, Nobuyuki Hinata, Taka-Aki Inoue, Ichiro Nakamura, Yuzo Nakano, Masato Fujisawa Comparison of the Perioperative and Postoperative Outcomes of Ileal Conduit and Cutaneous Ureterostomy: A Propensity Score-Matched Analysis. Urol Int. 2020 ;104(1-2):48-54.
• Tomohiko Yamamura, Tomoko Horinouchi, China Nagano, Takashi Omori, Nana Sakakibara, Yuya Aoto, Shinya Ishiko, Koichi Nakanishi, Yuko Shima, Hiroaki Nagase, Hiroki Takeda, Rini Rossanti, Ming Juan Ye, Yoshimi Nozu, Shingo Ishimori, Takeshi Ninchoji, Hiroshi Kaito, Naoya Morisada, Kazumoto Iijima, Kandai Nozu Genotype-phenotype correlations influence the response to angiotensin-targeting drugs in Japanese patients with male X-linked Alport syndrome. Kidney Int. 2020 Dec;98(6):1605-1614.
• Xiaoyuan Jia, Tomohiko Yamamura, Rasheed Gbadegesin, Michelle T McNulty, Kyuyong Song, China Nagano, Yuki Hitomi, Dongwon Lee, Yoshihiro Aiba, Seik-Soon Khor, Kazuko Ueno, Yosuke Kawai, Masao Nagasaki, Eisei Noiri, Tomoko Horinouchi, Hiroshi Kaito, Riku Hamada, Takayuki Okamoto, Koichi Kamei, Yoshitsugu Kaku, Rika Fujimaru, Ryojiro Tanaka, Yuko Shima, Jiwon Baek, Hee Gyung Kang, Il-Soo Ha, Kyoung Hee Han, Eun Mi Yang, Asiri Abeyagunawardena, Brandon Lane, Megan Chryst-Stangl, Christopher Esezobor, Adaobi Solarin, Claire Dossier, Georges Deschênes, Marina Vivarelli, Hanna Debiec, Kenji Ishikura, Masafumi Matsuo, Kandai Nozu, Pierre Ronco, Hae Il Cheong, Matthew G Sampson, Katsushi Tokunaga, Kazumoto Iijima Common risk variants in NPHS1 and TNFSF15 are associated with childhood steroid-sensitive nephrotic syndrome. Kidney Int, 2020 Nov;98(5):1308-1322.
• Tomohiko Yamamura, Tomoko Horinouchi, Tomomi Adachi, Maki Terakawa, Yutaka Takaoka, Kohei Omachi, Minoru Takasato, Kiyosumi Takaishi, Takao Shoji, Yoshiyuki Onishi, Yoshito Kanazawa, Makoto Koizumi, Yasuko Tomono, Aki Sugano, Akemi Shono, Shogo Minamikawa, China Nagano, Nana Sakakibara, Shinya Ishiko, Yuya Aoto, Misato Kamura, Yutaka Harita, Kenichiro Miura, Shoichiro Kanda, Naoya Morisada, Rini Rossanti, Ming Juan Ye, Yoshimi Nozu, Masafumi Matsuo, Hirofumi Kai, Kazumoto Iijima, Kandai Nozu Development of an exon skipping therapy for X-linked Alport syndrome with truncating variants in COL4A5. Nat Commun, 2020 Jun;11(1):2777.

再生医学分野

• Tomoyuki Kamenaga, Yuichi Kuroda, Kanto Nagai, Masanori Tsubosaka, Yoshinori Takashima, Kenichi Kikuchi, Masahiro Fujita, Kemmei Ikuta, Kensuke Anjiki, Toshihisa Maeda, Naoki Nakano, Koji Takayama, Shingo Hashimoto, Shinya Hayashi, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto Cryopreserved human adipose-derived stromal vascular fraction maintains fracture healing potential via angiogenesis and osteogenesis in an immunodeficient rat model. Stem Cell Res Ther. 2021 Feb;12(1):110.
• Masanori Tsubosaka, Tomoyuki Matsumoto, Satoshi Sobajima, Takehiko Matsushita, Hideki Iwaguro, Ryosuke Kuroda The influence of adipose-derived stromal vascular fraction cells on the treatment of knee osteoarthritis. BMC Musculoskelet Disord, 2020 Apr 6;21(1):207.
• Kei Saito, Hideki Fujii, Keiji Kono, Ken Hirabayashi, Satoshi Yamatani, Kentaro Watanabe, Shunsuke Goto, Shohei Komatsu, Takumi Fukumoto, Shinichi Nishi Changes in blood pressure during treatment with the tyrosine kinase inhibitor lenvatinib. Clin Kidney J. 2020 Oct21;14(1):325-331.
• Keiji Kono, Hideki Fujii, Kentaro Watanabe, Shunsuke Goto, Shinichi Nishi Relationship between parathyroid hormone and renin-angiotensin-aldosterone system in hemodialysis patients with secondary hyperparathyroidism. J Bone Miner Metab. 2021 Mar;39(2):230-236.
• Shinichi Nishi, Masayuki Yamada, Kazuhiko Tsuruya, Ikuto Masakane, Hidetomo Nakamoto Long-Term Safety and Efficacy of JR-131, a Biosimilar of Darbepoetin Alfa, in Japanese Patients with Renal Anemia Undergoing Hemodialysis: Phase 3 Prospective Study. Ther Apher Dial. 2020 Ap;24(2):136-145.
• Yasufumi Koterazawa, Michiyo Koyanagi-Aoi, Keiichiro Uehara, Yoshihiro Kakeji, Takashi Aoi Retinoic acid receptor γ activation promotes differentiation of human induced pluripotent stem cells into esophageal epithelium. J Gastroenterol. 2020 Aug;55(8):763-774.
• Witta Kartika Restu, Shota Yamamoto, Yuki Nishida, Hirotoshi Ienaga, Takashi Aoi, Tatsuo Maruyama Hydrogel formation by short D-peptide for cell-culture scaffolds. Mater Sci Eng C Mater Biol Appl. 2020 Jun;111:110746.
• Taichi Nakatani, Mitsuhiro Iwasaki, Atsuhiro Yamamichi, Yuta Yoshioka, Toshihiro Uesaka, Yuko Bitoh, Kosaku Maeda, Takumi Fukumoto, Tatsuya Takemoto, Hideki Enomoto Point mutagenesis in mouse reveals contrasting pathogenetic effects between MEN2B- and Hirschsprung disease-associated missense mutations of the RET gene. Dev Growth Differ. 2020 May;62(4):214-222.