CSMI
  1. トップ
  2. 業績

主要論文一覧(H30年度)

(国)は国際共著論文
センターメンバーにはアンダーライン

がん分野

  • (国)Weissenböck, M., Latham, R., Nishita, M., Wolff, L. I., Ho, H., Minami, Y., Hartmann, C. Genetic interactions between Ror2 and Wnt9a, Ror1 and Wnt9a and Ror2 and Ror1. Phenotypic analysis of the limb skeleton and palate in compound mutants. Genes Cells, 24(4): 307-317, 2019. doi: 10.1111/gtc.12676.
  • Kishimoto, K., Tamura, M., Nishita, M., Minami, Y., Matsuoka, A., Abe, T., Shigeta, M., Morimoto, M. Synchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus. Nat. Commun., 9 (1): 2816, 2018. doi: 10.1038/s41467-018-05189-2.
  • Saji, T., Nishita, M., Ogawa, H., Doi, T., Sakai, Y., Maniwa, M., Minami, Y. Critical role of the Ror-family of receptor tyrosine kinases in proliferation and invasion of malignant mesothelioma cells. Genes Cells.,　 23 (7): 606-613, 2018. doi: 10.1111/gtc.12599.
  • (国)Sato-Hashimoto, M., Nozu, T., Toriba, R., Horikoshi, A., Akaike, M., Kawamoto, K., Hirose, A., Hayashi, Y., Nagai, H., Shimizu, W., Saiki, A., Ishikawa, T., Elhanbly, R., Kotani, T., Murata, Y., Saito, Y., Naruse, M., Shibasaki, K., Oldenborg, PA., Jung, S., Matozaki, T., Fukazawa, Y., and Ohnishi, H. Microglial SIRPα regulates the emergence of CD11c+ microglia and demyelination damage in white matter. Elife., 8, pii: e42025, 2019.
  • (国)Matlung, HL., Babes, L., Zhao, XW., van Houdt, M., Treffers, LW., van Rees, DJ., Franke, K., Schornagel, K., Verkuijlen, P., Janssen, H., Halonen, P., Lieftink, C., Beijersbergen, RL., Leusen, JHW., Boelens, JJ., Kuhnle, I., van der Werff Ten Bosch, J., Seeger, K., Rutella, S., Pagliara, D., Matozaki, T., Suzuki, E., Menke- van der Houven van Oordt, CW., van Bruggen, R., Roos, D., van Lier, RAW., Kuijpers, TW., Kubes, P., and van den Berg, TK. Neutrophils kill antibody-opsonized cancer cells by trogoptosis. Cell Rep., 23, 3946- 3959.e6, 2018
  • Sun, C., Murata, Y., Imada, S., Konno, T., Kotani, T., Saito, Y., Yamada, H., and Matozaki, T. Role of Csk in intestinal epithelial barrier function and protection against colitis. Biochem Biophys Res Commun., 504, 109-114, 2018
  • Murata, Y., Saito, Y., Kotani, T., and Matozaki, T. CD47-signal regulatory protein α signaling system and its application to cancer immunotherapy. Cancer Sci., 109, 2349-2357, 2018.
  • Sawada, N., Kotani, T., Konno, T., Setiawan, J., Nishigaito, Y., Saito, Y., Murata, Y., Nibu, KI., and Matozaki, T. Regulation by commensal bacteria of neurogenesis in the subventricular zone of adult mouse brain. Biochem Biophys Res Commun., 498, 824-829, 2018.
  • Kodaira H, Koma Y, Hosono H, Higashino N, Suemune K, Nishio M, Shigeoka M, Yokozaki H ANXA10 induction by interaction with tumor-associated macrophages promotes the growth of esophageal squamous cell carcinoma. Patholology International, 69 : 135-147, 2019
  • Yanagihara K, Kubo T, Iino Y, Mihara K, Morimoto C, Seyama T, Kuwata T, Ochiai A, Yokozaki H Development and characterization of a cancer cachexia model employing a rare human duodenal neuroendocrine carcinoma-originating cell line. Oncotarget, 10 : 2435-2450, 2019
  • (国)Goto H, Nishio M, To Y, Oishi T, Miyachi Y, Maehama T, Nishina H, Akiyama H, Mak TW, Makii Y, Saito T, Yasoda A, Tsumaki N, Suzuki A Loss of Mob1a/b in mice results in chondrodysplasia due to YAP1/TAZ-TEADs-dependent repression of SOX9.　DEVELOPMENT 145(6), pii: dev159244, 2018
  • Li Y, Kobayashi K, Murayama K, Kawahara K, Shima Y, Suzuki A, Tani K, Takahashi A. FEAT enhances INSL3 expression in testicular Leydig cells.　GENES TO CELLS 23(11), 952-962, 2018
  • Maehara R, Fujikura K, Takeuchi K, Akita M, Abe-Suzuki S, Karbanová J, Corbeil D, Itoh T, Kakeji Y, Zen Y. SOX2-silenced squamous cell carcinoma: a highly malignant form of esophageal cancer with SOX2 promoter hypermethylation. Mod Pathol. 31(1):83-92, 2018.
  • Kana Sakaguchi, Yasuhito Shirai, Toshiki Itoh, and Masashi Mizuno Lentinan Exerts its Anti- Inflammatory Activity by Suppressing TNFR1 Transfer to the Surface of Intestinal Epithelial Cells through Dectin-1 in an in vitro and mice model Immune Res., 14(3), 1000165, 2018

代謝分野

  • Hirata Y, Nomura K, Senga Y, Okada Y, Kobayashi K, Okamoto S, Minokoshi Y, Imamura M, Takeda S, Hosooka T, Ogawa W. Hyperglycemia induces skeletal muscle atrophy via a WWP1/KLF15 axis. JCI Insight. 4(4). pii: 124952, 2019
  • Zhang B, Nakata M, Nakae J, Ogawa W, Yada T. Central insulin action induces activation of paraventricular oxytocin neurons to release oxytocin into circulation. Sci Rep. 10;8(1):10415, 2018
  • Yoshida N, Emoto T, Yamashita T, Watanabe H, Hayashi T, Tabata T, Hoshi N, Hatano N, Ozawa G, Sasaki N, Mizoguchi T, Amin HZ, Hirota Y, Ogawa W, Yamada T, Hirata K. Bacteroides vulgatus and Bacteroides dorei Reduce Gut Microbial Lipopolysaccharide Production and Inhibit Atherosclerosis. Circulation.;138(22):2486-2498. 2018.
  • Hayashi T, Yamashita T, Watanabe H, Kami K, Yoshida N, Tabata T, Emoto T, Sasaki N, Mizoguchi T, Irino Y, Toh R, Shinohara M, Okada Y, Ogawa W, Yamada T, Hirata K. Gut Microbiome and Plasma Microbiome-Related Metabolites in Patients With Decompensated and Compensated Heart Failure. Circ J.;83(1):182-192. 2018
  • Yoshida K, Fukuoka H, Odake Y, Nakajima S, Tachibana M, Ito J, Hosokawa Y, Yamada T, Miura H, Suematsu N, Matsumoto R, Bando H, Suda K, Nishizawa H, Iguchi G, Ogawa W, Takahashi Y Multiple salivary cortisol measurements are a useful tool to optimize metyrapone treatment in patients with Cushing’s syndromes treatment; case presentations. Front Endocrinol，8 : 375, 2018
  • Bando H, Iguchi G, Kanie K, Nishizawa H, Matsumoto R, Fujita Y, Odake Y, Yoshida K, Suda K, Fukuoka H, Tanaka K, Ogawa W, Takahashi Y Isolated adrenocorticotropic hormone deficiency as a form of paraneoplastic syndrome. Pituitary，21 : 480-489，2018
  • Takai, T., Matsuda, T., Matsuura, Y., Inoue, K., Suzuki, E., Kanno, A., Kimura-Koyanagi, M., Asahara, S., Hatano, N., Ogawa, W., Kido, Y. Casein kinase 2 phosphorylstes and stabilizes C/EBPβ in pancreatic β cells. Biochem Biophys Res Commun. 497: 451-456, 2018
  • Yano, H., Sakai, M., Matsukawa, T., Yagi, T., Naganuma, T., Mitsushima, M., Iida, S., Inaba, Y., Inoue, H., Unoki-Kubota, H., Kaburagi, Y., Asahara, S., Kido, Y., Minami, S., Kasuga, M., Matsumoto, M. PHD3 regulates glucose metabolism by suppressing stress-induced signalling and optimising gluconeogenesis and insulin signalling in hepatocytes Sci. Rep, 8: 14290, 2018
  • Kanno, A., Asahara, S., Kawamura, M., Suzuki, E., Takai, T., Koyanagi-Kimura, M., Matsuda, T., Okada, Y., Ogawa, W., Kido Y. Early administration of dapagliflozin preserves pancreatic beta cell mass through a legacy effect in type 2 diabetic mice. J. Diab. Invest. 10: 577-590, 2019

脳こころ分野

  • (国)Akiyoshi R, Wake H*, Kato D, Horiuchi H, Ono R, Ikegami A, Haruwaka K, Omori T, Tachibana Y, Moorhouse AJ and Nabekura J. Microglia enhance synapse activity to promote local network synchronization. eNeuro. Oct 25;5(5). Pii: ENEURO.0088-18. 2018.
  • Quan X, Kumar M, Matoba O, Awatsuji Y, Hayasaki Y, Hasegawa S, and Wake H. 3D Stimulation and Imaging-based Functional Optical Microscopy (SIFOM) of Biological Cells. Opt letters. 2018. Nov 1;43(21):5447-5450. 2018. Doi: 10.1364/OL.43.005447
  • (国)Dutta D, Woo DH, Lee PR, Pajevic S, Bukalo O, Huffman WC, Wake H, Basser PJ, Sheikhbahaei S, Lazarevic V, Smith JC & Fields RD. Regulation of myelin structure and conduction velocity by perinodal astrocytes. Proc Natl Acad Sci USA, Nov 13;115(46):11832-11837. 2018. Doi: 10. 1073/pnas. 1811013115
  • Takeda A, Shinozaki Y, Kashiwagi K, Ohno N, Eto K, Wake H, Nabekura J, Koizumi S. Microglia mediate non-cell-autonomous cell death of retinal ganglion cells. Glia. Nov;66(11):2366-2384. 2018.
  • (国)Ishikawa T, Eto K, Kim SK, Wake H, Takeda I, Horiuchi H, Moorhouse AJ, Ishibashi H, Nabekura J, Cortical astrocyte prime the induction of spine plasticity and mirro image pain. Pain. Aug;159(8):1592- 1606 2018 doi: 10.1097/j.pain.0000000000001248.
  • Hideki Shigematsu, Tsuyoshi Imasaki, Chihiro Doki, Takuya Sumi, Mari Aoki, Tomomi Uchikubo-Kamo, Ayako Sakamoto, Kiyotaka Tokuraku, Mikako Shirouzu, Ryo Nitta. Structural insight into microtubule stabilization and kinesin inhibition by Tau-family MAPs. J. Cell Biol. 217:,. 4155-4163, 2018
  • Tomohiro Shima, Manatsu Morikawa, Junichi Kaneshiro, Taketoshi Kambara, Shinji Kamimura, Toshiki Yagi, Hiroyuki Iwamoto, Sotaro Uemura, Hideki Shigematsu, Mikako Shirouzu, Taro Ichimura, Tomonobu M. Watanabe, Ryo Nitta, Yasushi Okada, Nobutaka Hirokawa. Kinesin-binding triggered conformation switching of microtubules contributes to polarized transport. J. Cell Biol: 217,. 4164-4183, 2018
  • Ryo Nitta, Tsuyoshi Imasaki, Eriko Nitta. Recent Progress in Structural Biology: Lessons from Our Research History. Microscopy, 67 : 1-3, 2018 doi: 10.1093/jmicro/dfy022.
  • Nie X, Kitaoka S, Tanaka K, Segi-Nishida E, Imoto Y, Ogawa A, Nakano F, Tomohiro A, Nakayama K, Taniguchi M, Mimori-Kiyosue Y, Kakizuka A, Narumiya S, Furuyashiki T. The innate immune receptors TLR2/4 mediate repeated social defeat stress-induced social avoidance through prefrontal microglial activation. Neuron: 99，464-479，2018
  • Higashida S, Nagai H, Nakayama K, Shinohara R, Taniguchi M, Nagai M, Hikida T, Yawata S, Ago Y, Kitaoka S, Narumiya S, Furuyashiki T. Repeated social defeat stress impairs attentional set shifting irrespective of social avoidance and increases female preference associated with heightened anxiety. Sci Rep，8：10454，2018
  • (国)Sumitomo A, Yukitake H, Hirai K, Horike K, Ueta K, Chung Y, Warabi E, Yanagawa T, Kitaoka S, Furuyashiki T, Narumiya S, Hirano T, Niwa M, Sibille E, Hikida T, Sakurai T, Ishizuka K, Sawa A, Tomoda T. Ulk2 controls cortical excitatory-inhibitory balance via autophagic regulation of p62 and GABAA receptor trafficking in pyramidal neurons. Hum Mol Genet，27 : 3165-3176，2018

免疫・炎症分野

  • Nagamata S, Nagasaka M, Kawabata A, Kishimoto K, Hasegawa D, Kosaka Y, Mori T, Morioka I, Nishimura N, Iijima K, Yamada H, Kawamoto S, Yakushijin K, Matsuoka H, Mori Y. Human CD134 (OX40) expressed on T cells plays a key role for human herpesvirus 6B replication after allogeneic hematopoietic stem cell transplantation. J Clin Virol. May 02 : 50-55., 2018
  • Matsui C, Deng L, Minami N, Abe T, Koike K and Shoji I. Hepatitis C virus NS5A protein promotes the lysosomal degradation of hepatocyte nuclear factor 1α via chaperone-mediated autophagy. Journal of Virology : 92: e000639-18, 1-14, 2018
  • Deng L, Gan X, Ito M, Chen M, Aly HH, Matsui C, Abe T, Watashi K, Wakita T, Suzuki T, Okamoto T, Matsuura Y, Mizokami M, Shoji I and Hotta H. Peroxiredoxin 1, a novel HBx-interacting protein, interacts with Exosc5 and negatively regulates HBV propagation through degradation of HBV RNA. Journal of Virology, , 93: e02203-18, 1-18, 2019
  • (国)Utsumi T, Wahyuni RM, Doan YH, Dinana Z, Soegijanto S, Fujii Y, Juniastuti, Yamani LN, Matsui C, Deng L, Abe T, Soetjipto, Lusida MI, Ishii K, Shimizu H, Katayama K, and Shoji I. Equine-like G3 rotavirus strains as predominant strains among children in Indonesia in 2015-2016. Infection, Genetics and Evolution, 61: 224-228, 2018
  • Noriko Goto, Mariko Tsujimoto, Hiroshi Nagai, Taro Masaki, Shosuke Ito, Kazumasa Wakamatsu, Chikako Nishigori. 4-(4-Hydroxyphenyl)-2-butanol (rhododendrol)-induced melanocyte cytotoxicity is enhanced by UVB exposure through generation of oxidative stress. Exp Dermatol 27 : 754-762, 2018.
  • Noriko Shimoura, Hiroshi Nagai, Susumu Fujiwara, Haruki Jimbo, Chikako Nishigori. Exacerbation and prolongation of psoriasiform inflammation in diabetic obese mice: A synergistic role of CXCL5 and ER stress. J Invest Dermatl: 138 : 854-863, 2018.
  • Nishida M, Saegusa J, Tanaka S, Morinobu A. S100A12 facilitates osteoclast differentiation from human monocytes. PLoS One. 13(9):e0204140:1-11. 2018.
  • Takaichi Okano, Jun Saegusa, Soshi Takahashi, Yo Ueda, Akio Morinobu Immunometabolism in rheumatoid arthritis. Immunological Medicine Vol 41, - Issue 3 Pages 89-97, 2018
  • Sendo S, Saegusa J, Morinobu A. Myeloid-derived suppressor cells in non-neoplastic inflamed organs. Inflamm Regen. 17;38:19. 2018
  • Kimura T, Suga T, Kameoka M, Ueno M, Inahashi Y, Matsuo H, Iwatsuki M, Shigemura K, Shiomi K, Takahashi Y, Ōmura S, Nakashima T New tetrahydroquinoline and indoline compounds containing a hydroxy cyclopentenone, virantmycin B and C, produced by Streptomyces sp. AM-2504. J Antibiot， 72(3)，PP. 169-173，2019
  • Ophinni Y, Inoue M, Kotaki T,Kameoka M CRISPR/Cas9 system targeting regulatory genes of HIV-1 inhibits viral replication in infected T-cell cultures. Sci Rep，8(1)，PP. 7784，2018
  • Perron A, Nishikawa Y, Iwata J, Shimojo H, Takaya J, Kobayashi K, Imayoshi I, Mbenza NM, Takenoya M, Kageyama R, Kodama Y, Uesugi M. Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone. J Biol Chem. 293, 8285-8294, 2018.
  • Sakuma Y, Kodama Y, Eguchi T, Uza N, Tsuji Y, Shiokawa M, Maruno T, Kuriyama K, Nishikawa Y, Yamauchi Y, Tsuda M, Ueda T, Matsumori T, Morita T, Tomono T, Kakiuchi N, Mima A, Sogabe Y, Marui S, Kuwada T, Okada A, Watanabe T, Nakase H, Chiba T, Seno H. Chemokine CXCL16 mediates acinar cell necrosis in cerulein induced acute pancreatitis in mice. Sci Rep. 8, 8829, 2018
  • Shiokawa M, Kodama Y, Sekiguchi K, Kuwada T, Tomono T, Kuriyama K, Yamazaki H, Morita T, Marui S, Sogabe Y, Kakiuchi N, Matsumori T, Mima A, Nishikawa Y, Ueda T, Tsuda M, Yamauchi Y, Sakuma Y, Maruno T, Uza N, Tsuruyama T, Mimori T, Seno H, Chiba T. Laminin 511 is a target antigen in autoimmune pancreatitis. Sci Transl Med. 10, 453, 2018.

創薬・医療機器分野

  • Jia X, Horinouchi T, Hitomi Y, Shono A, Khor SS, Omae Y, Kojima K, Kawai Y, Nagasaki M, Kaku Y, Okamoto T, Ohwada Y, Ohta K, Okuda Y, Fujimaru R, Hatae K, Kumagai N, Sawanobori E, Nakazato H, Ohtsuka Y, Nakanishi K, Shima Y, Tanaka R, Ashida A, Kamei K, Ishikura K, Nozu K, Tokunaga K, Iijima K; and for the Research Consortium on Genetics of Childhood Idiopathic Nephrotic Syndrome in Japan. Strong Association of the HLA-DR/DQ Locus with Childhood Steroid-Sensitive Nephrotic Syndrome in the Japanese Population. J Am Soc Nephrol: Aug;29(8):2189-2199. 2018 doi: 10.1681/ASN.2017080859. Epub Jul 16. 2018
  • Horinouchi T, Nozu K, Yamamura T, Minamikawa S, Omori T, Nakanishi K, Fujimura J, Ashida A, Kitamura M, Kawano M, Shimabukuro W, Kitabayashi C, Imafuku A, Tamagaki K, Kamei K, Okamoto K, Fujinaga S, Oka M, Igarashi T, Miyazono A, Sawanobori E, Fujimaru R, Nakanishi K, Shima Y, Matsuo M, Ye MJ, Nozu Y, Morisada N, Kaito H, Iijima K. Detection of Splicing Abnormalities and Genotype-Phenotype Correlation in X-linked Alport Syndrome. J Am Soc Nephrol : Aug;29(8):2244-2254. 2018 doi: 10.1681/ASN.2018030228. Epub Jun 29. 2018
  • Takahashi S, Kiyota N, Yamazaki T, Chayahara N, Nakano K, Inagaki L, Toda K, Enokida T, Minami H, Imamura Y, Fukuda N, Sasaki T*, Suzuki T, Ikezawa H, Dutcus CE, Tahara M. A phase II study of the safety and efficacy of lenvatinib in patients with advanced thyroid cancer. Future Oncology 15: 717-723, 2019
  • Suzuki C, Kiyota N, Imamura Y, Goto H, Suto H, Chayahara N, Toyoda M, Ito Y, Miya A, Miyauchi A, Otsuki N, Nibu K, Minami H. Exploratory analysis of prognostic factors for lenvatinib in radioiodine- refractory differentiated thyroid cancer. Head and Neck (doi: 0.1002/hed.25784, published on line, 2019)
  • (国)Nakazono, A., Adachi, N., Takahashi, H., Seki, T., Hamada, D., Ueyama, T., Sakai, N. and Saito, N. Pharmacological induction of heat shock proteins ameliorates toxicity of mutant PKCγ in spinocerebellar ataxia type 14.. J. Biol. Chem. 293(38)14758–14774, 2018
  • Morioka, S., Sakaguchi, H., Yamaguchi, T., Ninoyu , Y., Mohri, H., Nakamura, T., Hisa, Y., Ogita, K., Saito, N., Ueyama, T. Hearing vulnerability after noise exposure in a mouse model of reactive oxygen species overproduction. J. Neurochem. 146:459-473, (2018)
  • Sakamoto; I., Ueyama, T., Hayashibe; M., Nakamura, T.; Mohri; H., Kiyonari; H., Shigyo; M., Tohda; C., Saito, N Roles of Cdc42 and Rac in Bergmann glia during cerebellar corticogenesis. Experimental Neurology 302:57-67, 2018
  • Tanaka K, Teishima J, Takenaka A, Shiroki R, Kobayashi Y, Hattori K, Kanayama HO, Horie S, Yoshino Y, Fujisawa M. Prospective study of robotic partial nephrectomy for renal cancer in Japan: Comparison with a historical control undergoing laparoscopic partial nephrectomy. Int J Urol : May;25(5):472-478. 2018
  • Yamamichi F, Shigemura K, Kitagawa K, Fujisawa M. Predictive factors of improvement for voiding symptoms after holmium laser enucleation of the prostate. Int J Urol : Jan;26(1):136-137, 2019
  • Harada K, Nozawa M, Uemura M, Tatsugami K, Osawa T, Yamana K, Kimura G, Fujisawa M, Nonomura N, Eto M, Shinohara N, Tomita Y, Kondo Y, Ochi K, Anazawa Y, Uemura H. Treatment patterns and outcomes in patients with unresectable or metastatic renal cell carcinoma in Japan. Int J Urol :Feb;26(2):202-210, 2019

再生医学分野

各年度の主要論文一覧