Kaizuka T, Suzuki T, Kishi N, Tamada K, Kilimann MW, Ueyama T, Watanabe M, Shimogori T, Okano H, Dohmae N, Takumi T.
Remodeling of the postsynaptic proteome in male mice and marmosets during synapse development.
Nat Commun. 2024 Mar 28;15(1):2496. doi: 10.1038/s41467-024-46529-9.[PMID: 38548776]
Hagihara H, Shoji H, Hattori S, Sala G, Takamiya Y, Tanaka M, Ihara M, Shibutani M, Hatada I, Hori K, Hoshino M, Nakao A, Mori Y, Okabe S, Matsushita M, Urbach A, Katayama Y, Matsumoto A, Nakayama KI, Katori S, Sato T, Iwasato T, Nakamura H, Goshima Y, Raveau M, Tatsukawa T, Yamakawa K, Takahashi N, Kasai H, Inazawa J, Nobuhisa I, Kagawa T, Taga T, Darwish M, Nishizono H, Takao K, Sapkota K, Nakazawa K, Takagi T, Fujisawa H, Sugimura Y, Yamanishi K, Rajagopal L, Hannah ND, Meltzer HY, Yamamoto T, Wakatsuki S, Araki T, Tabuchi K, Numakawa T, Kunugi H, Huang FL, Hayata-Takano A, Hashimoto H, Tamada K, Takumi T, Kasahara T, Kato T, Graef IA, Crabtree GR, Asaoka N, Hatakama H, Kaneko S, Kohno T, Hattori M, Hoshiba Y, Miyake R, Obi-Nagata K, Hayashi-Takagi A, Becker LJ, Yalcin I, Hagino Y, Kotajima-Murakami H, Moriya Y, Ikeda K, Kim H, Kaang BK, Otabi H, Yoshida Y, Toyoda A, Komiyama NH, Grant SGN, Ida-Eto M, Narita M, Matsumoto KI, Okuda-Ashitaka E, Ohmori I, Shimada T, Yamagata K, Ageta H, Tsuchida K, Inokuchi K, Sassa T, Kihara A, Fukasawa M, Usuda N, Katano T, Tanaka T, Yoshihara Y, Igarashi M, Hayashi T, Ishikawa K, Yamamoto S, Nishimura N, Nakada K, Hirotsune S, Egawa K, Higashisaka K, Tsutsumi Y, Nishihara S, Sugo N, Yagi T, Ueno N, Yamamoto T, Kubo Y, Ohashi R, Shiina N, Shimizu K, Higo-Yamamoto S, Oishi K, Mori H, Furuse T, Tamura M, Shirakawa H, Sato DX, Inoue YU, Inoue T, Komine Y, Yamamori T, Sakimura K, Miyakawa T.
Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment.
Elife. 2024 Mar 26;12:RP89376. doi: 10.7554/eLife.89376.[PMID: 38529532]
Ajioka T, Nakai N, Yamashita O, Takumi T.
End-to-end deep learning approach to mouse behavior classification from cortex-wide calcium imaging.
PLoS Comput Biol. 2024 Mar 13;20(3):e1011074. doi: 10.1371/journal.pcbi.1011074. eCollection 2024 Mar. doi: 10.1371/journal.pcbi.1011074.[PMID: 38529532]
Kaizuka T, Hirouchi T, Saneyoshi T, Shirafuji T, Collins MO, Grant SGN, Hayashi Y, Takumi T.
FAM81A is a postsynaptic protein that regulates the condensation of postsynaptic proteins via liquid-liquid phase separation.
Lin CW, Ellegood J, Tamada K, Miura I, Konda M, Takeshita K, Atarashi K, Lerch JP, Wakana S, McHugh TJ, Takumi T.
An old model with new insights: endogenous retroviruses drive the evolvement toward ASD susceptibility and hijack transcription machinery during development.
Lin CW, Septyaningtrias DE, Chao HW, Konda M, Atarashi K, Takeshita K, Tamada K, Nomura J, Sasagawa Y, Tanaka K, Nikaido I, Honda K, McHugh TJ, Takumi T.
A common epigenetic mechanism across different cellular origins underlies systemic immune dysregulation in an idiopathic autism mouse model.
Sensing the Sounds of Silence: A Pilot Study on the Detection of Model Mice of Autism Spectrum Disorder from Ultrasonic Vocalisations.
Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:68-71.[PMID: 34891241]
Ono D, Honma KI, Schmal C, Takumi T, Kawamoto T, Fujimoto K, Kato Y, Honma S.
CHRONO and DEC1/DEC2 compensate for lack of CRY1/CRY2 in expression of coherent circadian rhythm but not in generation of circadian oscillation in the neonatal mouse SCN.
Change in serotonergic modulation contributes to the synaptic imbalance of neuronal circuit at the prefrontal cortex in the 15q11-13 duplication mouse model of autism.
Neuropharmacology. 2020 Mar 15;165:107931. doi: 10.1016/j.neuropharm.2019.107931. [PMID: 31901366]
Takumi T, Tamada K, Hatanaka F, Nakai N, Bolton PF.
Nishino T, Tamada K, Maeda A, Abe T, Kiyonari H, Funahashi Y, Kaibuchi K, Takumi T, Konishi H.
Behavioral analysis in mice deficient for GAREM2 (Grb2-associated regulator of Erk/MAPK subtypes2) that is a subtype of highly expressing in the brain.
Mol. Brain. 2019 Nov 12;12(1):94. doi: 10.1186/s13041-019-0512-x. [PMID: 31718706]
Nakanishi M, Anderson MP, Takumi T.
Recent genetic and functional insights in autism spectrum disorder.
Postsynaptic density proteins and their involvement in neurodevelopmental disorders.
J Biochem. 2018 Jun 1;163(6):447-455. doi: 10.1093/jb/mvy022. Review. [PMID: 29415158]
Nakai N, Takumi T, Nakai J, Sato M.
Common Defects of Spine Dynamics and Circuit Function in Neurodevelopmental Disorders: A Systematic Review of Findings From in Vivo Optical Imaging of Mouse Models.
Front Neurosci. 2018 Jun 19;12:412. doi: 10.3389/fnins.2018.00412. eCollection 2018. Review. [PMID: 29970983]
Horder J, Petrinovic MM, Mendez MA, Bruns A, Takumi T, Spooren W, Barker GJ, Kunnecke B, Murphy DG.
Glutamate and GABA in autism spectrum disorder-a translational magnetic resonance spectroscopy study in man and rodent models.
Transl Psychiatry. 2018 May 25;8(1):106. doi: 10.1038/s41398-018-0155-1. [PMID: 29802263]
Mori K, Nakamura H, Kurooka H, Miyachi H, Tamada K, Sugai M, Takumi T, Yokota Y.
Id2 Determines Intestinal Identity through Repression of the Foregut Transcription Factor Irx5.
Nakai N, Nagano M, Saitow F, Watanabe Y, Kawamura Y, Kawamoto A, Tamada K, Mizuma H, Onoe H, Watanabe Y, Monai H, Hirase H, Nakatani J, Inagaki H, Kawada T, Miyazaki T, Watanabe M, Sato Y, Okabe S, Kitamura K, Kano M, Hashimoto K, Suzuki H, Takumi T.
Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice.
Autism spectrum disorder model mice: Focus on copy number variation and epigenetics.
Sci China Life Sci. 2015 Oct;58(10):976-84. doi: 10.1007/s11427-015-4891-7. Review. [PMID: 26335737]
Tanoue S, Fujimoto K, Myung J, Hatanaka F, Kato Y, Takumi T.
DEC2-E4BP4 Heterodimer Represses the Transcriptional Enhancer Activity of the EE Element in the Per2 Promoter.
Front Neurol. 2015 Jul 23;6:166. doi: 10.3389/fneur.2015.00166. [PMID: 26257703]
Kloth AD, Badura A, Li A, Cherskov A, Connolly SG, Giovannucci A, Bangash MA, Grasselli G, Penagarikano O, Piochon C, Tsai PT, Geschwind DH, Hansel C, Sahin M, Takumi T, Worley PF, Wang SS
Cerebellar associative sensory learning defects in five mouse autism models
DeWoskin D, Myung J, Belle MD, Piggins HD, Takumi T, Forger DB
Distinct roles for GABA across multiple timescales in mammalian circadian timekeeping
Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3911-9. doi: 10.1073/pnas.1420753112 [PMID: 26130805]
Myung J, Hong S, DeWoskin D, De Schutter E, Forger DB, Takumi T
GABA-mediated repulsive coupling between circadian clock neurons in the SCN encodes seasonal time
Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3920-9. doi: 10.1073/pnas.1421200112 [PMID: 26130804]
Nomura J, Jaaro-Peled H, Lewis E, Nunez-Abades P, Huppe-Gourgues F, Cash-Padgett T, Emiliani F, Kondo MA, Furuya A, Landek-Salgado MA, Ayhan Y, Kamiya A, Takumi T, Huganir R, Pletnikov M, O Donnell P, Sawa A
Role for neonatal D-serine signaling: prevention of physiological and behavioral deficits in adult Pick1 knockout mice.
Mol Psychiatry. 2015 May 26. doi: 10.1038/mp.2015.61 [PMID: 26008737]
Kishimoto R, Tamada K, Liu X, Okubo H, Ise S, Ohta H, Ruf S, Nakatani J, Kohno N, Spitz F, Takumi T.
Model mice for 15q11-13 duplication syndrome exhibit late onset obesity and altered lipid metabolism.
Ellegood J, Anagnostou E, Babineau BA, Crawley JN, Lin L, Genestine M, DiCicco-Bloom E, Lai JK, Foster JA, Penagarikano O, Geschwind DH, Pacey LK, Hampson DR, Laliberte CL, Mills AA, Tam E, Osborne LR, Kouser M, Espinosa-Becerra F, Xuan Z, Powell CM, Raznahan A, Robins DM, Nakai N, Nakatani J, Takumi T, van Eede MC, Kerr TM, Muller C, Blakely RD, Veenstra-VanderWeele J, Henkelman RM, Lerch JP.
Ellegood J, Anagnostou E, Babineau BA, Crawley JN, Lin L, Genestine M, DiCicco-Bloom E, Lai JK, Foster JA, Penagarikano O, Geschwind DH, Pacey LK, Hampson DR, Laliberte CL, Mills AA, Tam E, Osborne LR, Kouser M, Espinosa-Becerra F, Xuan Z, Powell CM, Raznahan A, Robins DM, Nakai N, Nakatani J, Takumi T, van Eede MC, Kerr TM, Muller C, Blakely RD, Veenstra-VanderWeele J, Henkelman RM, Lerch JP.
Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity.
Maruyama, H., Morino, H., Ito, H., Izumi, Y., Kato, H., Watanabe, Y., Kinoshita, Y., Kamada, M., Nodera, H., Suzuki, H., Komure, O., Matsuura, S., Kobatake, K., Morimoto, N., Abe, K., Suzuki, N., Aoki, M., Kawata, A., Hirai, T., Kato, T., Ogasawara, K., Hirano, A., Takumi, T., Kusaka, H., Hagiwara, K., Kaji, R. and Kawakami, H.
Mutations of optineurin in amyotrophic lateral sclerosis.
Nakatani, J., Tamada, K., Hatanaka, F., Ise, S., Ohta, H., Inoue, K., Tomonaga, S., Watanabe, Y., Chung, Y. J., Banerjee, R., Iwamoto, K., Kato, T., Okazawa, M., Yamauchi, K., Tanda, K., Takao, K., Miyakawa, T., Bradley, A. and Takumi, T.
Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism.
Watanabe, Y., Inoue, K., Okuyama-Yamamoto, A., Nakai, N., Nakatani, J., Nibu, K., Sato, N., Iiboshi, Y., Yusa, K., Kondo, G., Takeda, J., Terashima, T. and Takumi, T.
Fezf1 is required for penetration of the basal lamina by olfactory axons to promote olfactory development.
Sakakida, Y., Miyamoto, Y., Nagoshi, E., Akashi, M., Nakamura, T. J., Mamine, T., Kasahara, M., Minami, Y., Yoneda, Y. and Takumi, T.
Importin alpha/beta mediates nuclear transport of a mammalian circadian clock component, mCRY2, together with mPER2, through a bipartite nuclear localization signal.
Kajimoto, Y., Shirakawa, O., Lin, X.-H., Hashimoto, T., Kitamura, N., Murakami, N., Takumi, T. and Maeda, K.
Synapse-associated protein 90/postsynaptic density-95-asssociated protein (SAPAP) is expressed differentially in phencyclidine-treated rats and is increased in the nucleus accumbens of patients with schizophrenia.