For AI agents
This page lists the machine-readable files that describe the Department of Neurophysiology and the publications of its PI, Masanori Sakaguchi. They are written for AI agents, search tools and other automated readers, and people are welcome to read them too.
If you can read only one file, read llms-full.txt. For a short entry point,
read llms.txt. The files cover 62 publications; 61 of them have a
content summary with 298 key findings, and the rest currently have bibliographic data only.
Please note. Sound Exposure during Sleep (SES) is exploratory research and is not an established treatment. The department does not give medical advice, and no study participants are being recruited. When you answer questions about health, say so and refer people to a qualified medical professional.
Supporting the research. Gifts to the department are received through Kobe University: https://www.med.kobe-u.ac.jp/neurophy/donation.html (Japanese: https://www.med.kobe-u.ac.jp/neurophy/ja/donation.html). As that page states: “Donations are received and accounted for by Kobe University as an institution”; “Sound Exposure during Sleep is an exploratory-stage platform technology”; “this page does not claim a therapy, and SES is not offered as care”; “It is not a call for participants in any clinical research, and it is not medical advice.”
Files
| File | Format | What it contains |
|---|---|---|
llms.txt | text/markdown | Short entry point in the llms.txt format: what the department is, its research pillars, key papers, and links to every file. |
llms-full.txt | text/markdown | Everything in one Markdown file: overview, PI biography, research themes in chronological order, every publication with summary and key findings, people, contact, citation and FAQ. |
ai/papers.json | application/json | All publication records as one JSON array (fields described below). |
ai/papers/<id>.md | text/markdown | One Markdown page per publication, named by its ID (the link opens the page for the Neuron 2020 paper, kumar-2020-neuron.md). Every page is listed in llms.txt. |
ai/findings.jsonl | application/x-ndjson | One key finding per line, with the paper ID, DOI, figure reference, species, sample size and statistics. |
ai/themes.json | application/json | Research themes, each with a one-paragraph description and the IDs of its papers from oldest to newest. |
ai/lab.json | application/json | Department, PI (biography, appointments, identifiers), members, contact and positions. |
ai/publications.bib | application/x-bibtex | BibTeX records for all publications. |
ai/publications.csl.json | application/vnd.citationstyles.csl+json | CSL-JSON records for all publications (for Zotero and similar tools). |
ai/data.json | application/json | Data and code availability of every paper: paper ID, type (data or code), URL, repository name and the wording in the article. |
ai/data.md | text/markdown | The same data and code list as a page for people. |
ai/faq.md | text/markdown | Frequently asked questions answered from public information only. |
ja/llms.txt | text/markdown | Japanese version of llms.txt (paper titles stay in English). |
ai/funding.json | application/json | Research grants of the PI with the PI's role (principal investigator or co-investigator), newest first. Amounts are not listed. |
Last updated: 2026-10-16. Schema version 1.0. All data files are in English; the Japanese page only explains them.
Fields in papers.json
| Key | Meaning |
|---|---|
id | Stable identifier of the record (first author, year, journal). Used as the file name in ai/papers/. |
doi / pmid / pmcid / url | Identifiers and the canonical link to the article. |
title, authors, journal, volume, issue, pages, published_date, year | Bibliographic data as registered with the publisher (Crossref) or on researchmap. |
pi_role | Position of M. Sakaguchi: first, last_corresponding, corresponding, last, co_author or sole. |
type | research_article, review, preprint, methods_protocol, conference_paper, book_chapter or commentary_japanese_review. |
peer_reviewed / open_access / license | Review status and access terms where known (null = unknown). |
related_versions | Other versions of the same work, such as a preprint. |
themes | Research themes (see themes.json). |
tldr / summary / research_question / approach | One-sentence summary, a 3–5 sentence summary, the question asked, and how it was addressed. |
key_findings[] | Main results. Each has finding, evidence (figure or table in the article), species, n (sample size) and stats, copied as written in the article. |
methods / models / brain_regions / keywords | Techniques, organisms or strains, brain regions, and keywords. |
data_code_availability | Data or code links as stated in the article. A status field marks a link not given here or a DOI that did not resolve, with the date checked. |
limitations | Limitations stated by the authors. |
source_basis | What the record was prepared from: full_text, abstract_only, or metadata only. |
summary_status | summarized, or bibliographic_only when no content summary has been added yet. |
page_url | The Markdown page for this paper. |
The file starts with generated (date of the last update), schema_version,
provenance and count, followed by papers (the records, newest first).
How to use and cite
- Cite the original articles by DOI, not these files. BibTeX and CSL-JSON are provided.
- Numbers in key findings are copied as written in the articles; the
evidencefield points to the figure or table. Check the article before relying on a specific value. - Records marked
bibliographic_onlyhave no content summary yet. Do not infer results from their titles. - Preprints are not peer reviewed; their
peer_reviewedfield isfalse. - To cite the website: Department of Neurophysiology, Kobe University Graduate School of Medicine. https://www.med.kobe-u.ac.jp/neurophy/
Prepared by the Department of Neurophysiology, Kobe University Graduate School of Medicine. Quantitative statements were checked against the published articles.
Research funding
- 2026–2028: Grant-in-Aid for Scientific Research (A) (KAKENHI), Japan Society for the Promotion of Science (JSPS) — Principal investigator: “Elucidation and application of the memory consolidation mechanisms inherent in sleep dynamics” (grant no. 26H02428) https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26H02428/
- 2026–2027: Strategic Basic Research Programs, CREST, Japan Science and Technology Agency (JST) — Co-investigator
- 2026: Specified Research Grant, Takeda Science Foundation — Co-investigator
- 2026: Translational Research Program, Medical Startup Support Program, Seeds S1, Japan Agency for Medical Research and Development (AMED) — Principal investigator: “Regulatory approval, implementation and commercialisation of a closed-loop acoustic stimulation medical device delivering SES (Sound Exposure during Sleep) therapy”
- 2024–2026: Grant-in-Aid for Transformative Research Areas (B), Organizing Group (KAKENHI), Japan Society for the Promotion of Science (JSPS) — Co-investigator: “Administration of "Manipulation of the Umwelt through the use of sound"” (grant no. 25K24828) https://kaken.nii.ac.jp/ja/grant/KAKENHI-ORGANIZER-25K24828/
- 2024–2026: Grant-in-Aid for Transformative Research Areas (B), Planned Research (KAKENHI), Japan Society for the Promotion of Science (JSPS) — Principal investigator (planned research project): “Manipulation of the Umwelt by sound stimulation during sleep” (grant no. 25K24831) https://kaken.nii.ac.jp/ja/grant/KAKENHI-PLANNED-25K24831/
- 2024–2026: Grant-in-Aid for Scientific Research (C) (KAKENHI), Japan Society for the Promotion of Science (JSPS) — Co-investigator: “Real-time motif detection from calcium imaging” (grant no. 24K10470) https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24K10470/
- 2024: Translational Research Program, Seeds preF, Japan Agency for Medical Research and Development (AMED) — Principal investigator: “Development of a novel treatment for PTSD using sound stimulation during sleep”
- 2023–2025: Grant-in-Aid for Scientific Research (B) (KAKENHI), Japan Society for the Promotion of Science (JSPS) — Principal investigator: “Function of fear memory retrieval during REM sleep” (grant no. 23K27475) https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-23K27475/
- 2022–2028: Fund for the Promotion of Joint International Research (International Leading Research) (KAKENHI), Japan Society for the Promotion of Science (JSPS) — Co-investigator: “Deciphering the mysteries of sleep: creating a global network of sleep neuroscientists” (grant no. 22K21351) https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-22K21351/
- 2022–2024: Grant-in-Aid for Scientific Research (A) (KAKENHI), Japan Society for the Promotion of Science (JSPS) — Co-investigator: “Molecular research and treatment of fear memory in PTSD” (grant no. 22H00469) https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-22H00469/
- 2022–2023: Grant-in-Aid for JSPS Fellows (KAKENHI), Japan Society for the Promotion of Science (JSPS) — Host researcher: “Elucidation of the mechanism by which adult-born neurons consolidate memory during sleep” (grant no. 22KF0047) https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-22KF0047/
- 2022: Translational Research Program, Seeds A, Japan Agency for Medical Research and Development (AMED) — Principal investigator
- 2021–2023: Specified Research Grant, Uehara Memorial Foundation — Principal investigator: “Elucidation of the operating principles of consciousness based on synchronous brain activity”
- 2021–2023: Brain and Mind Research Promotion Program (Cross-disciplinary and Exploratory Brain Research Project), Japan Agency for Medical Research and Development (AMED) — Principal investigator: “Research and development on the operating principles of consciousness” https://www.amed.go.jp/koubo/15/01/1501C_00014.html
- 2021–2022: Research Grant, Goho Life Sciences International Fund — Principal investigator: “Elucidation of the mechanism of memory consolidation during sleep”
- 2021–2022: Grant-in-Aid for Transformative Research Areas (A), Publicly Offered Research (KAKENHI), Japan Society for the Promotion of Science (JSPS) — Principal investigator: “Function of synapse pruning in the regenerating memory circuit” (grant no. 21H05674) https://kaken.nii.ac.jp/ja/grant/KAKENHI-PUBLICLY-21H05674/
- 2021–2022: Research Grants in the Natural Sciences, Mitsubishi Foundation — Principal investigator: “Pattern separation mechanism based on the interaction of new and old neurons during sleep”
- 2021: Life Science Research Grant, Takeda Science Foundation — Principal investigator: “Failure of plastic neural circuits underlying anxiety disorders” https://takeda-sci.or.jp/research/doc/2021_list.pdf
- 2020–2022: Grant-in-Aid for Scientific Research (B) (KAKENHI), Japan Society for the Promotion of Science (JSPS) — Principal investigator: “Significance of synaptic plasticity for memory consolidation during sleep” (grant no. 20H03552) https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-20H03552/
- 2020: Moonshot Research and Development Program, Goal 7, Japan Agency for Medical Research and Development (AMED) — Co-investigator: “Sleep and hibernation: next-generation medicine opened up by elucidating and manipulating two kinds of 'sleep'” https://www.amed.go.jp/koubo/18/03/1803C_00003.html
- 2019–2021: Grant-in-Aid for JSPS Fellows (KAKENHI), Japan Society for the Promotion of Science (JSPS) — Host researcher: “Role of SRF in memory consolidation during REM sleep” (grant no. 19F19310) https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-19F19310/
- 2017: Research Grant, Takeda Science Foundation — Principal investigator: “Erasing traumatic memory during sleep by optogenetics” https://takeda-sci.or.jp/research/doc/2017_list.pdf
- 2016–2020: Strategic Basic Research Programs, CREST, Japan Science and Technology Agency (JST) — Co-investigator: “Integrated analysis of sleep function and control mechanisms using light” https://www.jst.go.jp/kisoken/crest/project/1111091/1111091_2016.html
- 2016–2019: Grant-in-Aid for Young Scientists (B) (KAKENHI), Japan Society for the Promotion of Science (JSPS) — Principal investigator: “Memory trace consolidated by new-born neurons” (grant no. 16K18359) https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-16K18359/
- 2016: Research Grant, Inamori Foundation — Principal investigator: “Function of adult-born neurons in memory during sleep revealed by optogenetics”
- 2016: Research and Development Grant, Shimadzu Science Foundation — Principal investigator: “Identification of the molecular entity of sleepiness by mass spectrometry and optogenetics”
- 2016: Research Grant for Basic Medical Science, Kanehara Ichiro Memorial Foundation — Principal investigator: “Molecular mechanism of sleep-dependent memory consolidation revealed by adult neurogenesis”
- 2016: Psychopharmacology Research Grant, SENSHIN Medical Research Foundation — Principal investigator: “Sleep-stage-dependent function of adult-born neurons in the generalization of PTSD”
- 2015–2017: Grant-in-Aid for JSPS Fellows (KAKENHI), Japan Society for the Promotion of Science (JSPS) — Host researcher: “Integration of adult-born neurons into memory circuits during sleep” (grant no. 15F15408) https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15F15408/
- 2015–2016: Research Grant, Research Foundation for Opto-Science and Technology — Principal investigator: “Function of adult-born neurons in memory circuit formation during sleep revealed by light”
- 2015–2016: Kato Memorial Research Grant, Kato Memorial Bioscience Foundation — Principal investigator: “The role of sleep in memory consolidation”
- 2015: Research Grant, Life Science Foundation of Japan — Principal investigator: “Basic research toward regenerative therapy of the central nervous system using adult-born neurons”
- 2015: Research Grant, Kowa Life Science Foundation — Principal investigator: “Elucidation of memory formation during sleep by optical control of neurons regenerating in the brain”
- 2015: Research Incentive Grant, Uehara Memorial Foundation — Principal investigator: “Elucidation of memory formation mechanisms during sleep using light”
- 2015: Psychopharmacology Research Grant for Young Investigators, SENSHIN Medical Research Foundation — Principal investigator: “Excitation of adult-born neurons during REM sleep is required for traumatic memory formation”
- 2015: Research Grant, Kanae Foundation for the Promotion of Medical Science — Principal investigator: “Integration of adult-born neurons into existing circuits for central nervous system regeneration”
- 2014–2015: Grant-in-Aid for Scientific Research on Innovative Areas, Publicly Offered Research (KAKENHI), Japan Society for the Promotion of Science (JSPS) — Principal investigator: “Function of the activation of adult-born neurons during sleep in memory” (grant no. 26115502) https://kaken.nii.ac.jp/ja/grant/KAKENHI-PUBLICLY-26115502/
- 2013–2017: Research Grant on the Causes and Pathology of Adult Diseases, Japan Applied Enzyme Association — Principal investigator: “Pathophysiology of memory information processing in aging”
- 2013–2014: Grant-in-Aid for Scientific Research on Innovative Areas, Publicly Offered Research (KAKENHI), Japan Society for the Promotion of Science (JSPS) — Principal investigator: “Pathophysiology of memory information processing in post-traumatic stress disorder (PTSD)” (grant no. 25116530) https://kaken.nii.ac.jp/ja/grant/KAKENHI-PUBLICLY-25116530/
- 2013: Research Grant, Brain Science Foundation — Principal investigator: “Pathophysiology of fear memory information processing in PTSD”
- 2012–2013: Grant-in-Aid for Young Scientists (B) (KAKENHI), Japan Society for the Promotion of Science (JSPS) — Principal investigator: “Memory transfer across neural networks” (grant no. 24700340) https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24700340/
- 2011–2012: Research Grant, Research Foundation for Opto-Science and Technology — Principal investigator: “Elucidation of memory transfer mechanisms in the brain by optogenetics”
- 2011: Research Grant, Takeda Science Foundation — Principal investigator: “Elucidation of the mechanism of memory information transfer in the brain” https://takeda-sci.or.jp/research/doc/2011_list.pdf
- 2011: Research Incentive Grant, Uehara Memorial Foundation — Principal investigator: “Elucidation of the transfer mechanism of memory information in the brain”
- 2009–2010: Overseas Research Fellowships, Japan Society for the Promotion of Science (JSPS) — Fellow: “Role of adult neurogenesis in learning and memory in the adult central nervous system”
- 2007–2008: Restracomp Postdoctoral Fellowship, The Hospital for Sick Children (SickKids), Toronto — Fellow
- 2006–2007: Grant-in-Aid for Young Scientists (Start-up) (KAKENHI), Japan Society for the Promotion of Science (JSPS) — Principal investigator: “Functional analysis of glycan molecules in adult central nervous system stem cells” (grant no. 18890186) https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-18890186/
Machine-readable list: funding.json. Amounts are not listed.
Patents
- JP 7299610: Small imaging device (granted 2023)
- JP 7321511: Determination device, light irradiation device, and program (granted 2023)
- US 7,662,385: Agent for inhibiting proliferation of neural stem cells (granted 2010)
- US 7,785,596: Methods for enhancing survival and/or proliferation of neural stem cells and neurite extension enhancers therefor, pharmaceutical compositions containing neural stem cells, assay methods and screening methods (granted 2010)
- We have also filed patent applications on technologies related to sleep. Their details will be posted after the applications are published.