2020年～2016年

 

2020年

Maehama T, Nishio M, Otani J, Mak TW, Suzuki A. 
The Role of Hippo‐YAP Signaling in Squamous Cell Carcinomas
Cancer Science 112(1):51-60,2021    doi: 10.1111/cas.14725.

哺乳類Hippo経路による細胞接着の制御と細胞競合
前濱 朝彦、西尾 美希、鈴木　聡
医学のあゆみ　274(5) 457-462, 2020

Nishio M, To Y, Maehama T, Aono Y, Otani J, Hikasa H, Kitagawa A, Mimori K, Sasaki T, Nishina H, Toyokuni S, Lydon J, Nakao K, Mak TW, Kiyono T, Katabuchi H, Tashiro H, Suzuki A.
Endogenous YAP1 activation Drives Immediate Onset of Cervical Carcinoma in Situ in Mice.
Cancer Science　111(10):3576-3587, 2020

Ishihara E, Nagaoka Y, Okuno T, Kofuji S, Ishigami-Yuasa M, Kagechika H, Kamimura K, Terai S, Yokomizo T, Sugimoto Y, Fujita Y, Suzuki A, Nishina H.
Prostaglandin E2 and its receptor EP2 trigger signaling that contributes to YAP-mediated cell competition.
Genes Cells.25(3):197-214. 2020

Omori H, Nishio M, Masuda M, Miyachi Y, Ueda F, Nakano T, Sato K, Mimori K, Taguchi K, Hikasa H, Nishina H, Tashiro H, Kiyono T, Mak TW, Nakao K, Nakagawa T, Maehama T, Suzuki A.
YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma.
Sci Adv.18;6(12):eaay3324. 2020

---

2019年

Kato W, Nishio M, To Y, Togashi H, Mak TW, Takada H, Ohga S, Maehama T, Suzuki A.
MOB1 regulates thymocyte egress and T-cell survival in mice in a YAP1-independent manner.
Genes Cells. 24(7):485-495. 2019

Shimono Y, Mukohyama J, Isobe T, Johnston DM, Dalerba P, Suzuki A
Organoid Culture of Human Cancer Stem Cells
Methods Mol Biol 1576, 23-31, 2019

Mukohyama J, Isobe T, Hu Q, Hayashi T, Watanabe T, Maeda M, Yanagi H, Qian X, Yamashita K, Minami H, Mimori K, Sahoo D, Kakeji Y, Suzuki A, Dalerba P, Shimono Y.
miR-221 Targets QKI to Enhance the Tumorigenic Capacity of Human Colorectal Cancer Stem Cells.
Cancer Res. 79(20):5151-5158, 2019

Nishio M, Miyachi Y, Otani J, Tane S, Omori H, Ueda F, Togashi H, Sasaki T, Mak TW, Nakao K, Fujita Y, Nishina H, Maehama T, Suzuki A.
Hippo pathway controls cell adhesion and context-dependent cell competition to influence skin engraftment efficiency.
FASEB J. 33, 5548, 2019

Uegaki M, Kita Y, Shirakawa R, Teramoto Y, Kamiyama Y, Saito R, Yoshikawa T, Sakamoto H, Goto T, Akamatsu S, Yamasaki T, Inoue T, Suzuki A, Horiuchi H, Ogawa O, Kobayashi T.
Downregulation of RalGTPase-activating protein promotes invasion of prostatic epithelial cells and progression from intraepithelial neoplasia to cancer during prostate carcinogenesis.
Carcinogenesis, 40(12):1535-1544, 2019

PCT国際出願（2018年度の国内特許出願をさらに国際出願）
発明の名称：癌モデル非ヒト哺乳動物
令和元年(2019年)7月8日
出願番号：PCT/JP2019/026950

---

2018年

Li Y, Kobayashi K, Murayama K, Kawahara K, Shima Y, Suzuki A, Tani K, Takahashi A.
FEAT enhances INSL3 expression in testicular Leydig cells.
Genes to Cells, 23(11):952-962, 2018

Goto H, Nishio M, To Y, Oishi T, Miyachi Y, Maehama T, Nishina H, Akiyama H, Mak TW, Makii Y, Saito T, Yasoda A, Tsumaki N, Suzuki A.
Loss of Mob1a/b in mice results in chondrodysplasia due to YAP1/TAZ-TEADs-dependent repression of SOX9.
DEVELOPMENT 145(6), pii: dev159244, 2018

特願第2018-130573号
大森 裕文、西尾 美希、鈴木　聡
癌モデル非ヒト哺乳動物
神戸大学
平成30(2018)年7月10日出願

---

2017年

Miyamura N, Hata S, Itoh T, Tanaka M, Nishio M, Itoh M, Ogawa Y, Terai S, Sakaida I, Suzuki A, Miyajima A, Nishina H.
YAP determines the cell fate of injured mouse hepatocytes in vivo.
NATURE COMMUNICATIONS 8:16017, 2017.

Mukohyama J, Shimono Y, Minami H, Kakeji Y, Suzuki A.
Roles of microRNAs and RNA-Binding Proteins in the Regulation of Colorectal Cancer Stem Cells.
CANCERS (Basel) 9(10), pii: E143, 2017.

Nambara S, Masuda T, Nishio M, Kuramitsu S, Tobo T, Ogawa Y, Hu O, Iguchi T, Kuroda Y, Ito S, Eguchi H, Sugimachi K, Saeki H, Oki E, Maehara Y, Suzuki A, Mimori K.
Antitumor effects of the antiparasitic agent ivermectin via inhibition of Yes-associated protein 1 expression in gastric cancer.
ONCOTARGET 8(64):107666-107677, 2017.

Kondo H, Shimono Y, Mukohyama J, Tanaka Y, Shibuya N, Minami H, Kakeji Y, Suzuki A.
Discordance of MCM7 mRNA and its intronic microRNA levels under hypoxia.
ANTICANCER RESEARCH 37(7), 3885-3890, 2017

Sugimachi K, Nishio M, Aishima S, Kuroda Y, Iguchi T, Komatsu H, Hirata H, Sakimura S, Eguchi H, Bekki Y, Takenaka K, Maehara Y, Suzuki A, Mimori K.
Altered expression of Hippo signaling pathway molecules in intrahepatic cholangiocarcinoma.
ONCOLOGY 93(1): 67-74, 2017

Otsubo K, Goto H, Nishio M, Kawamura K, Yanagi S, Nishie W, Sasaki T, Maehama T, Nishina H, Mimori K, Nakano T, Shimizu H, Mak TW , Nakao K, Nakanishi Y, Suzuki A
MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion, and tumor formation
ONCOGENE 36(29): 4201-4211, 2017

Okada Y, Sonoshita M, Kakizaki F, Aoyama N, Itatani Y, Uegaki M, Sakamoto H, Kobayashi T, Inoue T, Kamba T, Suzuki A, Ogawa O, Taketo M.
Amino-terminal enhancer of split gene AES encodes a tumor and metastasis suppressor of prostate cancer
CANCER SCIENCE, 108(4), 744-752, 2017 doi: 10.1111/cas.13187

Kimura H, Eguchi S, Sasaki J, Kuba K, Nakanishi H, Takasuga S, Yamazaki M, Goto A, Watanabe H, Itoh H, Imai Y, Suzuki A, Mizushima N, Sasaki T.
Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy
JCI INSIGHT 12;2(1):e89462, 2017

Yang YR, Jung JH, Kim SJ, Hamada K, Suzuki A, Kim HJ, Lee JH, Kwon OB, Lee YK, Kim J, Kim EK, Jang HJ, Kang DS, Choi JS, Lee CJ, Marshall J, Koh HY, Kim CJ, Seok H, Kim SH, Choi JH, Choi YB, Cocco L, Ryu SH, Kim JH, Suh PG.
Forebrain-specific ablation of phospholipase Cγ1 causes manic-like behavior
MOLECULAR PSYCHIATRY, 22(10), 1473-1482, 2017 doi:10.1038/mp.2016.261.

Nishio M, Maehama T, Goto H, Nakatani K, Kato W, Omori H, Miyachi Y, Togashi H, Shimono Y, Suzuki A.
Hippo vs. Crab: Tissue-specific functions of the mammalian Hippo pathway　
GENES TO CELLS, 22(1):6-31, 2017

---

2016年

Saito F, Tashiro H, Yamaguchi M, Honda R, Ohba T, Suzuki A, Katabuchi H.
Development of a mouse model for testing therapeutic agents: the anticancer effect of dienogest on endometrial neoplasms.
GYNECOL ENDOCRINOL, 32(5):403-7, 2016

Nakatani K, Maehama T, Nishio M, Goto H, Kato W, Omori H, Miyachi Y, Togashi H, Shimono Y, Suzuki A.
Targeting the Hippo Signaling Pathway for Cancer Treatment　
JOURNAL OF BIOCHEMISTRY, pii: mvw074, 2016　

Chiba T, Ishihara E, Miyamura N, Narumi R, Kajita M, Fujita Y, Suzuki A, Ogawa Y, Nishina H
MDCK cells expressing constitutively active Yes-associated protein (YAP) undergo apical extrusion depending on neighboring cell status
SCIENTIFIC REPORT 6:28383, 2016

後藤裕樹、西尾美希、加藤稚子、前濱朝彦、鈴木聡
機械的刺激によるHippo-YAZ/TAZ経路の活性化、生理作用、腫瘍進展メカニズムと意義
（特集：細胞の社会学ー細胞間で繰り広げられる協調と競争）
生体の科学　67(2), 127-131, 2016

Matsushita Y, Sakai Y, Shimmura M, Shigeto H, Nishio M, Akamine S, Sanefiji M Ishizaki Y, Torisu H, Nakabeppu Y, Suzuki A, Takada H, Hara T
Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice
SCIENTIFIC REPORTS 6:22991, 2016

西尾美希、鈴木聡
YAP1/TAZおよびTGFβ経路を介したMOB1A/1B欠損による肝がん発症機構
肝細胞研究会, ホットトピックス, 2016
（http://hepato.umin.jp/hottopics/hottopics014.html）

Hikasa H, Sekido Y, Suzuki A
Merlin/NF2-Lin28B-let-7 is a novel tumor-suppressive pathway that is cell density-dependent and Hippo-independent
CELL REPORTS 14(12):2950-61, 2016

特許第2016-107726号
鈴木 聡、西尾美希、後藤裕樹
新規化合物及びその製造方法、並びにその新規化合物を含有する医薬組成物
国立研究開発法人産業技術総合研究所、一般社団法人バイオ産業情報化コンソーシアム
平成28(2016)年5月30日出願