2015年～2011年

 

2015年

Nishio M, Sugimachi K, Goto H, Wang J, Morikawa T, Miyachi Y, Takano Y, Hikasa H, Itoh T, Suzuki SO, Kurihara H, Aishima S, Leask A, Sasaki T, Nakano T, Nishina H, Nishikawa Y, Sekido Y, Nakao K, Shin-ya K, Mimori K, Suzuki A
Dysregulated YAP1/TAZ and TGF-beta signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCE USA 113(1), E71-80, 2016

西尾美希、鈴木聡
Hippo経路による生体制御機構
耳鼻咽喉科ニューロサイエンス　29, 1-5, 2015

前濱朝彦, 鈴木聡
PTEN:脂質ホスファターゼとしての機能と発がんへの関与
実験医学 33(15), 157-163, 2015

前濱朝彦、鈴木聡
家族性腫瘍学ー家族性腫瘍の最新研究動向ー
日本臨床　73 (6) 285-290

Murata Y, Kotani T, Supriatna Y, Kitamura Y, Imada S, Kawahara K, Nishio M, Daniwijaya EW Sadakata H, Kusakari S, Mori M, Kanazawa Y, Saito Y, Okawa K, Takeda-Morishita M, Okazawa H, Ohnishi H, Azuma T, Suzuki A, Matozaki T
Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCE USA 112(31),E4264-71, 2015

Takahashi Y, Sheridan P, Niida A, Sawada G, Uchi R, Mizuno H, Kurashige J, Sugimachi K, Sasaki S, Shimada Y, Hase K, Kusunoki M, Kudo S, Watanabe M, Yamada K, Sugihara K, Yamamoto H, Suzuki A, Doki Y, Miyano S, Mori M, Mimori K
The AURKA/TPX2 axis drives colon tumorigenesis cooperatively with MYC.
ANNALS OF ONCOLOGY 26(5), 935-42, 2015

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2014年

Nagahama Y, Sone M, Chen X, Okada Y, Yamamoto M, Xin B, Matsuo Y, Komatsu M,?Suzuki A, Enomoto K, Nishikawa Y
Contributions of hepatocytes and bile ductular cells in ductular reactions and remodeling of the biliary system after chronic liver injury.?
AMERICAN JOURNAL OF PATHOLOGY 184(11), 3001-12, 2014

Yamamoto-Kataoka S, Ebihara K, Aizawa-Abe M, Nishio M, Kusakabe T, Yamamoto Y, Aotani D, Sakai T, Zhao M, Ebihara C, Gumbilai VM, Hosoda K, Suzuki A, Nakao K.
Leptin improves fatty liver independently of insulin sensitization and appetite suppression in hepatocytespecific Pten-deficient mice with insulin hypersensitivity
HORMONE AND METABOLIC RESEARCH 47(3), 168-75, 2015

前濱朝彦、鈴木聡
がんと脂質－PTEN/PI3Kシグナルと発がん
THE LIPID 25(4). 63-69, 2014

Hayashi K, Momoi Y, Tanuma N, Kishimoto A, Ogoh H, Kato H, Suzuki M, Sakamoto Y, Inoue Y, Nomura M, Kiyonar H, Sakayori M, Fukamachi K, Kakugawa Y, Yamashita Y, Ito S, Sato I, Suzuki A, Nishio M, Suganuma M, Watanabe T, Shima H
Abrogation of protein phosphatase 6 promotes skin carcinogenesis induced by DMBA
ONOCOGENE 34(35), 4647-55, 2015

後藤裕樹、西尾美希、杉町圭史、三森功士、鈴木 聡
Hippo経路と腫瘍－Hippo経路変異によるがんモデルマウス－
医学のあゆみ 251(5), 428-435, 2014

Nishio M, Goto H, Suzuki M, Fujimoto A, Mimori K, Suzuki A
The Hippo Signaling Pathway: A Candidate New Drug Target for Malignant Tumors
INNOVATIVE MEDICINE : Basic Research and Development (editted by Nakao K), Springer, 79-94, 2015

Pulido R, Baker SJ, Barata JT,Carracedo A, Cid VJ, Chin-Sang ID, Dave V, den Hertog J, Devreotes P,Eickholt BJ, Eng C, Furnari FB, Georgescu MM, Gericke A, Hopkins B, Jiang X, Lee SR, Losche M, Malaney P, Matias-Guiu X, Molina M, Pandolfi PP, Parsons R, Pinton P, Rivas C, Rocha RM, Rodriguez MS, Ross AH, Serrano M, Stambolic V, Stiles B, Suzuki A, Tan SS, Tonks NK, Trotman LC, Wolff N, Woscholski R, Wu H, Leslie NR
A Unified Nomenclature and Amino Acid Numbering for Human PTEN
SCIENCESIGNALING 7(332) Pe15, 1-4, 2014

Maehama T, Kawahara K, Nishio M, Suzuki A, Hanada K
Nucleolar Stress Induces Ubiquitination-Independent Proteasomal Degradation of PICT1
JOURNAL OF BIOLOGICAL CHEMISTRY 289(30), 20802-12, 2014

Okamura K, Takayama K, Kawahara K, Harada T, Nishio M, Otsubo K, Ichijo K, Kohno M, Iwama E, Fujii A, Ota K, Koga T, Okamoto T, Suzuki A, Nakanishi Y
PICT1 expression is a good prognostic factor in non-small cell lung cancer
ONCOSCIENCE 1 (5), 375-82, 2014

Kajimoto H, Kai H, Aoki H, Uchiwa H, Aoki Y, Yasuoka S, Anegawa T, Mishina Y, Suzuki A, Fukumoto Y, Imaizumi T
BMP type I Receptor Inhibition Attenuates Endothelial Dysfunction in Mice with Chronic Kidney Disease
KIDNEY INTERNATIONAL 87(1), 128-36, 2014

Wang L, Opland D, Tsai S, Luk CT, Schroer SA, Allison MB, Elia AJ, Furlonger C, Suzuki A, Paige CJ, Mak TW, Winer DA, Myers MG Jr, Woo M.
Pten deletion in RIP-Cre neurons protects against type 2 diabetes by activating the anti-inflammatory reflex NATURE MEDICINE 20(5), 484-92, 2014

特許第2014-228901号
新家一男、鈴木 聡、西尾美希、日笠弘基、関戸好孝
イベルメクチン又はミルベマイシンDを有効成分として含む抗癌剤
独立行政法人 産業技術総合研究所
平成26 (2014) 年11月11日出願

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2013年

Taguchi K, Hirano I, Itoh T, Tanaka M, Miyajima A, Suzuki A, Motohashi H, Yamamoto M
Nrf2 enhances cholangiocyte expansion in Pten-deficient livers
MOLECULAR AND CELLULAR BIOLOGY 34(5), 900-13, 2014

Sugimachi K, Yokobori T, Iinuma H, Ueda M, Ueo H, Shinden Y, Eguchi H, Sudo T, Suzuki A, Maehara Y, Mori M, Mimori K
Aberrant Expression of Plastin-3 Via Copy Number Gain Induces the Epithelial-Mesenchymal Transition in Circulating Colorectal Cancer Cells.
ANNALS OF SURGICAL ONCOLOGY 21(11), 3680-90, 2014

Dong Y, Sui L, Yamaguchi F, Kamitori K, Hirata Y, Hossain MA, Noguchi C, Katagi A, Nishio M, Suzuki A, Tokuda M.
The expression of PTEN in the development of mouse cochlear lateral wall. NEURO SCIENCE 258(1), 263-9, 2014

Uchi R, Kogo R, Kawahara K, Sudo T, Yokobori T, Eguchi H, Sugimachi K, Maehama T, Mori M, Suzuki A, Komune S, Mimori K.
PICT1 regulates TP53 via RPL11 and is involved in gastric cancer progression.
BRITISH JOURNAL OF CANCER 109(8), 2199-206, 2013

Nishio M, Otsubo K, Maehama T, Mimori K, Suzuki A
Capturing the Mammalian Hippo: Elucidating Its Role in Cancer
CANCER SCIENCE 104(10), 1271-1277, 2013

Liao J, Marumoto T, Yamaguchi S, Okano S, Takeda N, Sakamoto C, Kawano H, Nii T, Miyamato S, Nagai Y, Okada M, Inoue H, Kawahara K, Suzuki A, Miura Y, Tani K.
Inhibition of PTEN Tumor Suppressor Promotes the Generation of Induced Pluripotent Stem Cells.
MOLECULAR THERAPY 21(6),1242-50, 2013

Ishibashi M, Kogo R, Shibata K, Ueo H, Uchi R, Matsumura T, Takano Y, Sawada G, Takahashi Y, Mima K, Kurashige J, Akiyoshi S, Iwaya T, Eguchi H, Sudo T, Sugimachi K, Suzuki A, Wakabayashi G, Mori M, Mimori K.
Clinical Significance of PICT1 in Patients of Hepatocellular Carcinoma with Wild-Type TP53.
ANNALS OF SURGICAL ONCOLOGY, Suppl 3, S537-44, 2013

Takasuga S, Horie Y, Sasaki J, Sun-Wada GH, Kawamura N, Iizuka R, Mizuno K, Eguchi S, Kofuji S, Kimura H, Yamazaki M, Horie C, Odanaga E, Sato Y, Sato Y, Chida S, Kotani K, Harada A, Katada T, Suzuki A, Wada Y, Ohnishi H, Sasaki T.
Critical roles of type Ⅲ phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCE USA 110(5); 1726-31,2013

西尾美希、河原康一、佐々木雅人、前濱朝彦、佐々木雄彦、三森功士、森　正樹、鈴木　聡
核小体を起点としp53を制御する新規分子PICT1による細胞増殖制御機構
実験医学増刊号　31 (2) 127-134, 2013

西尾美希、三森功士、森　正樹、板見　智、鈴木　聡
Hippo経路分子MOB1によるがん発症・進展制御とがん治療戦略
次世代がん戦略研究update　がん基盤生物学 －革新的シーズ育成に向けて－
南山堂 p200-5, 2013

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2012年

Nishio M, Hamada K, Kawahara K, Sasaki M, Noguchi F, Chiba S, Mizuno K, Suzuki SO, Dong Y, Tokuda M, Morikawa T, Hikasa H, Eggenschwiler J, Yabuta N, Nojima H, Nakagawa K, Hata Y, Nishina H, Mimori K, Mori M, Sasaki T, Mak TW, Nakano T, Itami S, Suzuki A
Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice
JOURNAL OF CLINICAL INVESTIGATION 122(12), 4505-18, 2012

Miyoshi K, Yanagi S, Kawahara K, Nishio M, Tsubouchi H, Imazu Y, Koshida R, Matsumoto N, Tagichi A, Yamashita S, Suzuki A, Nakazato M
Epithelial Pten controls acute lung Injury and fibrosis by regulating alveolar epithelial cell integrity
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 187(3); 262-75, 2012

Panasyuk G, Espeillac C, Chauvin C, Pradelli LA, Horie Y, Suzuki A, Annicotte JS, Faias L, Foretz M, Verdeguer F, Pontoglio M, Ferre P, Scoazec JY, Bimbaum MJ, Ricci JE, Pende M
PPARgamma contributes to PKM2 and HK2 expression in fatty liver
NATURE COMMUNICATIONS 3, 672, 2012

Suzuki A, Kogo R, Kawahara K, Sasaki M, Nishio M, Maehama T, Sasaki T, Mimori K, Mori M
A new PICTure of the nucleolar stress
CANCER SCIENCE 103(4), 632-637, 2012

河原康一、西尾美希、佐々木雅人、前濱朝彦、佐々木雄彦、古後龍之介、三森功士、森　正樹、鈴木　聡
PICT1による核小体ストレス経路を介したp53と腫瘍進展制御～腫瘍予後マーカーや今後の創薬応用にむけて～
遺伝子Mook22号　最新疾患モデルと病態解明、創薬応用研究、細胞医薬創製研究の最前線、メディカルドゥ社　260-65, 2012

西尾美希、佐々木雄彦、鈴木聡
PTEN変異による発がんモデル
疾患モデルの作製と利用 ー がん （エル・アイ・シー社）－145-171, 2012

古後龍之介、三森功士、小宗静男、鈴木聡、森　正樹
核小体ストレス経路を介したp53制御遺伝子PICT1遺伝子の機能～特に大腸癌について～
大腸癌 Frontier 5(2), 175(82)-179(89)

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2011年

Sasaki　M, Kawahara K(equal contribution), Nishio M, Mimori K, Kogo R, Hamada K, Itoh B, Wang J, Komatsu Y, Yang YR, Hikasa H, Horie Y, Yamashita T, Kamijo T, Zhang Y, Zhu Y, Prives C, Nakano T, Mak TW, Sasaki T, Marehama T, Mori M, Suzuki A
Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11
NATURE MEDICINE 17(8): 944-951, 2011
（私達のものがこの号のTopicとして News and Viewsに選ばれました）

Kogo R, shimamura T, Mimori K, Kawahara K, Imoto S, Sudo T, Tanaka F, Shibata K, Suzuki A, Komune S, Miyano S, Mori M
Long noncoding RNA HOTAIR regulates polycomb-dependent chromartin modification and is associated with poor prognosis in colorectal cancers.
CANCER RESEARCH 71(20): 6320-6326, 2011

Saito F, Tashiro H, To Y, Ohtake H, Ohba T, Suzuki A, Katabuchi H
Mutual contribution of Pten and estrogen to endometrial carcinogenesis in a PtenloxP/loxP mouse model
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER 21(8): 1343-1349, 2011

Ikegami D, Akiyama H, Suzuki A, Nakamura T, Nakano T, Yoshikawa H, Tsumaki N.
Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathway.
DEVELOPMENT 138(8): 1507-1519, 2011