研究・業績

当科での研究内容

  • 肺癌細胞における遺伝子,蛋白異常とその臨床的意義についての研究
  • 癌宿主相互作用と癌浸潤のメカニズムの研究
  • 肺癌におけるバイオマーカーの探索
  • 肺癌手術における低侵襲手術の確立
  • 転移性肺腫瘍治療における潜在病巣のコントロール
  • 胸部感染疾患に対する治療戦略
  • 嚢胞性肺疾患の手術における合理的な手技の確立
  • Ex. vivo lung perfusionを用いた新しい臓器保存法の確立

実績

英文

  • Minami K, Jimbo N, Tanaka Y, Uchida T, Okamoto T, Shimizu N, Doi T,  Hokka D, Itoh T, Maniwa Y. Fibrous bands associated with higher Masaoka stage and poor recurrence-free survival in patients with thymoma.
    Thorac Cancer. 12(3):349-356, 2021.
  • Mitsui S, Tanaka Y, Kimura K, Jimbo N, Chihara N, Maniwa Y. Paraneoplastic Neuromyelitis Optica Spectrum Disorder Associated with Atypical Thymic Carcinoid: A Case Report.
    Ann Thorac Cardiovasc Surg. in press.
  • Tanaka Y, Yamamoto H, Sato M, Toyooka S, Okada M, Endo S, Sato Y, Suzuki K, Maniwa Y, Fukuchi E, Miyata H, Chida M. Preoperative cumulative smoking dose on lung cancer surgery in a Japanese nationwide database.
    Ann Thorac Surg. 113(1):237-243, 2022.
  • Uchida T, Tanaka Y, Kuroda S, Hokka D, Maniwa Y. Successful treatment of refractory empyema using dual sheet covering.
    Asian Cardiovasc Thorac Ann. in press.
  • Hokka D, Tanaka Y, Shimizu N, Doi T, Maniwa Y. Oxidized Regenerated Cellulose Sheets in Postoperative Intrathoracic Adhesions.
    Ann Thorac Cardiovasc Surg. in press
  • Shimizu N, Tanaka Y, Tachihara M, Maniwa Y. ROS1-rearranged lung cancer successfully resected after response to crizotinib: A case report
    Kobe J. Med. Sci., in press
  • Mitsui S, Tauchi S, Tanaka Y, Tobe S. Pulmonary arteriovenous fistula ruptured in an adolescent girl 1 week after her mother's rupture: a report of a case.
    Gen Thorac Cardiovasc Surg. 69(1):130-132, 2021.
  • Nishikubo M, Kin Y, Tane S, Nakamura K, Miyagi Y, Miura A, Nishio W, Senzaki H, Uchino K. Cellular cannibalism and consequent thrombocytopenia in a patient with bone marrow metastasis of malignant pleural mesothelioma: A case report.
    Mol Clin Oncol. 15(2):163, 2021.
  • Mitsui S, Tauchi S, Uchida T, Ohnishi H, Shimokawa T, Tobe S. Low suction on digital drainage devices promptly improves post-operative air leaks following lung resection operations: a retrospective study.
    J Cardiothorac Surg. 2021 Apr 21;16(1):105.
  • Mitsui S, Tauchi S.
    Tension pyopneumothorax.
    BMJ Case Rep. 14(3):e242197, 2021.
  • Mitsui S, Tauchi S, Mizuki S, Tobe S.
    Extended-spectrum β-lactamase-producing Escherichia coli rib osteomyelitis with debridement and vacuum-assisted closure.
    BMJ Case Rep. 14(1):e238029, 2021.
  • Jimbo N, Tateyama H, Komatsu M, Doi T, Tanaka Y, Maniwa Y, Itoh T.
    A case of type AB thymoma with atypical histological features: Is atypical type AB thymoma an acceptable variant of thymoma?
    Pathol Int. 71(4):272-274, 2021.
  • Saito T, Ono R, Tanaka Y, Tatebayashi D, Okumura M, Makiura D, Inoue J, Fujikawa T, Kondo S, Inoue T, Maniwa Y, Sakai Y.
    The effect of home-based preoperative pulmonary rehabilitation before lung resection: a retrospective cohort study.
    Lung Cancer. in press
  • Safety and Immunogenicity of the COVID-19 Vaccine BNT162b2 in Patients Undergoing Chemotherapy for Solid Cancer
    Journal of Infection and Chemotherapy. In press
  • Nishikubo M, Jimbo N, Tanaka Y, Tachihara M, Itoh T, Maniwa Y. Sarcomatoid mesothelioma originating from mesothelioma in situ: are methylthioadenosine phosphorylase loss and CDKN2A homozygous deletion poor prognostic factors for preinvasive mesothelioma? Virchows Arch. 2022 Jan 19. doi: 10.1007/s00428-022-03281-z. Epub ahead of print. PMID: 35043235.
  • Suguru Mitsui , Yugo Tanaka, Takefumi Doi, Daisuke Hokka, Yoshimasa Maniwa
    Prognostic value of preoperative plasma fibrinogen levels in resected stage I non-small cell lung cancer
    Thorac cancer 2022;13:1490-1495.
  • Tane S, Kitazume M, Fujibayashi Y, Kuroda S, Kimura K, Kitamura Y, Takenaka D, Nishio W. The difference in postoperative pulmonary functional change between upper and lower thoracoscopic segmentectomy. Interact Cardiovasc Thorac Surg, 2022; 34(3): 408-415.
  • Tane S, Kimura K, Shimizu N, Kitamura Y, Matsumoto G, Uchino K, Nishio W. Segmentectomy for inner location non-small-cell lung cancer: Is it feasible? Ann Thorac Surg, Article in press, 2022. 
  • Fujibayashi Y, Tane S, Kitazume M, Kuroda S, Kimura K, Kitamura Y, Nishio W. Resected stage I anaplastic lymphoma kinase-positive lung adenocarcinoma has a negative impact on recurrence-free survival. Thoracic Cancer, 2022; 13(8): 1109-1116.
  • Tane S, Ando Y, Matsumoto G, Ueda S, Uchino K. Basal segment deep wedge resection for lung cancer with pulmonary fibrosis. Gen Thorac Cardiovasc Surg. 2022; 70(4): 413-415.
  • Minami K, Jimbo N, Tanaka Y, et al. Malignant mesothelioma in situ diagnosed by methylthioadenosine phosphorylase loss and homozygous deletion of CDKN2A: a case report. Virchows Arch. 2020;476(3):469-473.
  • Kimura K, Ogawa H, Jimbo N, Hokka D, Tanaka Y, Maniwa Y. A case of leiomyosarcoma originating from a bronchogenic cyst: A case report. Mol Clin Oncol. 2020;12(3):244‐246.
  • Jimbo N, Kawahara K, Tsukamoto R, et al. Malignant pleural mesothelioma showing intrapulmonary lepidic spread. Pathol Int. 2020;70(6):373-375.
  • Minami K, Jimbo N, Tanaka Y, et al. Insulinoma-associated protein 1 is a prognostic biomarker in pulmonary high-grade neuroendocrine carcinoma. J Surg Oncol. 2020;122(2):243-253.
  • Minami K, Tanaka Y, Ogawa H, et al. Neuroendocrine marker staining pattern categorization of small-sized pulmonary large cell neuroendocrine carcinoma. Thorac Cancer. 2019;10(11):2152‐2160.
  • Ogawa H, Tanaka Y, Kitamura Y, et al. Efficacy of perioperative chemotherapy for pulmonary high-grade neuroendocrine carcinomas: a propensity score matching analysis. J Thorac Dis. 2019;11(4):1145‐1154.
  • Shimizu N, Tanaka Y, Maniwa Y. Establishment of a safe thoracoscopic surgery. J Thorac Dis. 2019;11(Suppl 9):S1430‐S1431.
  • Uchida T, Tanaka Y, Shimizu N, et al. Diaphragmatic plication for iatrogenic respiratory insufficiency after cardiothoracic surgery. J Thorac Dis. 2019;11(9):3704‐3711.
  • Ogawa H, Tanaka Y, Tachihara M, et al. ROS1-rearranged high-PD-L1-expressing lung adenocarcinoma manifesting as mediastinal tumor: A case report. Oncol Lett. 2019;17(1):488‐491.
  • Shimizu N, Tanaka Y, Demizu Y, Okimoto T, Maniwa Y. Surgery and Proton Beam Therapy for Mediastinal Extraskeletal Osteosarcoma. Ann Thorac Surg. 2019;108(5):e289‐e291.
  • Tsuboshima K, Matoba Y, Wakahara T, Maniwa Y. Natural history of bulla neogenesis for primary spontaneous pneumothorax: a propensity score analysis. Gen Thorac Cardiovasc Surg. 2019;67(5):464‐469.
  • Kimura K, Tanaka Y, Tauchi S, et al. Psf3 as a possible biomarker of postoperative chemotherapy for patients with early pulmonary adenocarcinoma. Thorac Cancer. 2019;10(12):2300‐2307.
  • Tsuboshima K, Wakahara T, Matoba Y, Maniwa Y. Pleural Coating by 50% Glucose Solution Reduces Postoperative Recurrence of Spontaneous Pneumothorax. Ann Thorac Surg. 2018;106(1):184‐191.
  • Shimizu N, Tanaka Y, Okamoto T, Doi T, Hokka D, Maniwa Y. How to prevent adverse events of vascular stapling in thoracic surgery: recommendations based on a clinical and experimental study. J Thorac Dis. 2018;10(12):6466‐6471.
  • Saji T, Nishita M, Ogawa H, et al. Critical role of the Ror-family of receptor tyrosine kinases in invasion and proliferation of malignant pleural mesothelioma cells. Genes Cells. 2018;23(7):606‐613.
  • Kishida Y, Seki S, Yoshikawa T, et al. Performance Comparison Between 18F-FDG PET/CT Plus Brain MRI and Conventional Staging Plus Brain MRI in Staging of Small Cell Lung Carcinoma. AJR Am J Roentgenol. 2018;211(1):185‐192.
  • Ogawa H, Koyanagi-Aoi M, Otani K, Zen Y, Maniwa Y, Aoi T. Interleukin-6 blockade attenuates lung cancer tissue construction integrated by cancer stem cells. Sci Rep. 2017;7(1):12317. Published 2017 Sep 26.
  • Tanaka Y, Hokka D, Ogawa H, Shimizu N, Inoue T, Tanaka H, Okita Y, Maniwa Y. Surgery for malignant lesions of the chest which extensively involved the mediastinum, lung, and heart. Gen Thorac Cardiovasc Surg. 2017;65:365-373.
  • Tauchi S, Sakai Y, Fujimoto S, Ogawa H, Tane S, Hokka D, Tanaka Y, Nishio W, Yoshimura M, Yanagita E, Itoh T, Hayashi Y, Maniwa Y. Psf3 is a prognostic biomarker in lung adenocarcinoma: a larger trial using tissue microarrays of 864 consecutive resections. Eur J Cardiothorac Surg. 2016;50:758-764.
  • Tanaka Y, Tane S, Hokka D, Ogawa H, Maniwa Y. The Use of Oxidized Regenerated Cellulose for Video-Assisted Thoracic Surgery. Ann Thorac Surg. 2016;101:786-8.
  • Hokka D, Ogawa H, Tane S, Tanaka Y, Tauchi S, Maniwa Y. Ruptured thymoma causing a hemothorax: A case report. Oncol Lett. 2015;10:1810-1812.
  • Tane S, Sakai Y, Hokka D, Okuma H, Ogawa H, Tanaka Y, Uchino K, Nishio W, Yoshimura M, Maniwa Y. Significant role of Psf3 expression in non-small-cell lung cancer. Cancer Sci. 2015;106:1625-34.
  • Tane S, Nishio W, Okuma H, Ogawa H, Hokka D, Tane K, Tanaka Y, Uchino K, Yoshimura M, Maniwa Y. Operative outcomes of thoracoscopic lobectomy for non-small-cell lung cancer. Asian Cardiovasc Thorac Ann. 2015;23:950-7
  • Ogawa H, Uchino K, Tanaka Y, Shimizu N, Okuda Y, Tane K, Tauchi S, Nishio W, Maniwa Y, Yoshimura M. Efficacy of adjuvant chemotherapy for lung adenocarcinoma patients with positive pleural lavage cytology findings. Interact Cardiovasc Thorac Surg. 2015;21:34-9.
  • Tomono A, Nakamura T, Otowa Y, Imanishi T, Tanaka Y, Maniwa Y, Kakeji Y. A Case of Benign Esophageal Schwannoma Causing Life-threatening Tracheal Obstruction. Ann Thorac Cardiovasc Surg. 2015;21:289-92.
  • Ogawa H, Uchino K, Tanaka Y, Shimizu N, Okuda Y, Tane K, Hokka D, Tane S, Tauchi S, Nishio W, Maniwa Y, Yoshimura M. Outcomes of segmentectomy for cT1bN0M0 lung adenocarcinoma and squamous cell carcinoma: a possible association with pathological invasion. Eur J Cardiothorac Surg. 2015;48:77-82.
  • Tanaka Y, Noda K, Isse K, Tobita K, Maniwa Y, Bhama JK, D'Cunha J, Bermudez CA, Luketich JD, Shigemura N. A Novel Dual Ex Vivo Lung Perfusion Technique Improves Immediate Outcomes in an Experimental Model of Lung Transplantation. Am J Transplant. 2015;15:1219-30.
  • Hokka D, Uchino K, Tane K, Ogawa H, Tane S, Tanaka Y, Tauchi S, Nishio W, Yoshimura M, Maniwa Y. Pleural lavage cytology as an independent prognostic factor in non-small-cell lung cancer patients with stage I disease and adenocarcinoma. Mol Clin Oncol. 2015 Jan;3:244-248.
  • Tane S, Nishio W, Ogawa H, Hokka D, Tane K, Tanaka Y, Tauchi S, Uchino K, Sakai Y, Ohbayashi C, Yoshimura M, Maniwa Y. Clinical significance of the “not otherwise specified" subtype in candidates for resectable non-small cell lung cancer. Oncol Lett. 2014;8:1017-1024.
  • Tanaka Y, Shigemura N, Noda K, Kawamura T, Isse K, Stolz DB, Bermudez CA.Optimal lung inflation techniques in a rat lung transplantation model: A revisit. Thorac Cardiovasc Surg. 2014;62:427-33.
  • Ogawa H, Tanaka Y, Koma Y, Hokka D, Tane S, Tauchi S, Uchino K, Yoshimura M, Maniwa Y. Pulmonary Large Cell Neuroendocrine Carcinoma showing extensive “pagetoid spread" in the bronchial epithelium. Oncol Lett.2014;8:2621-2623.
  • Noda K, Shigemura N, Tanaka Y, Bhama JK, D'Cunha J, Luketich JD, Bermudez CA. Successful prolonged ex vivo lung perfusion for graft preservation in rats. Eur J Cardiothorac Surg. 2014;45:e54-60.
  • Noda K, Shigemura N, Tanaka Y, Bhama J, D'Cunha J, Kobayashi H, Luketich JD, Bermudez CA. Hydrogen preconditioning during ex vivo lung perfusion improves the quality of lung grafts in rats. Transplantation. 2014;98:499-506
  • Chen X, Hokka D, Maniwa Y, Ohbayashi C, Itoh T, Hayashi Y. Sirt1 is a tumor promoter in lung adenocarcinoma. Oncol Lett. 2014;8:387-393.
  • Seki S, Koyama H, Ohno Y, Nishio M, Takenaka D, Maniwa Y, Itoh T, Nishimura Y, Sugimura K.Diffusion-weighted MR imaging vs. multi-detector row CT: Direct comparison of capability for assessment of management needs for anterior mediastinal solitary tumors. Eur J Radiol. 2014;83:835-42.
  • Tsuboshima K, Wakahara T, Matoba Y, Miyauchi H, Hayashi C, Kobayashi I, Oue H, Watanabe Y, Ono T, Maniwa Y. Single-incision thoracoscopic surgery using a chest wall pulley for lung excision in patients with primary spontaneous pneumothorax. Surg Today. 2015;45:595-9.
  • Tane S, Ohno Y, Hokka D, Ogawa H, Tauchi S, Nishio W, Yoshimura M, Okita Y, Maniwa Y. The efficacy of 320-detector row CT for Assessment of Preoperative Pulmonary Vasculature of Candidates for Pulmonary Segmentectomy. Interact Cardiovasc Thorac Surg. 2013;17:974-80.
  • Hokka D, Maniwa Y, Tane S, Nishio W, Yoshimura M, Okita Y, Ohbayashi C, Sakai Y, Chen X, Hayashi Y. Psf3 is a prognostic biomarker in lung adenocarcinoma. Lung Cancer 2013;79:77-82.
  • Tane S, Maniwa Y, Hokka D, Tauchi S, Nishio W, Okita Y, Yoshimura M. The role of Necl-5 in the invasive activity of lung adenocarcinoma. Exp Mol Pathol 2013;94:330-5.
  • Tanaka Y, Ogawa H, Uchino K, Ohbayashi C, Maniwa Y, Nishio W, Nakao A, Yoshimura M. Immunohistochemical studies of pulmonarylarge cell neuroendocrine carcinoma: a possible association between staining patterns with neuroendocrine markers and tumor response to chemotherapy. J Thorac Cardiovasc Surg 2013;145:839-46.
  • Tane S, Nishio W, Hokka D, Maniwa Y, Yoshimura M. Ewing's sarcoma family of tumors originating in the main bronchus. Thoracic Cancer 2012;3:353-356.
  • Noda K(※), Tanaka Y(※), Shigemura N, Kawamura T, Wang Y, Masutani K, Sun X, Toyoda Y, Bermudez CA, Nakao A, Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration. Transpl Int 2012;25:1213-22 (※)These authors contributed to this work equally.
  • Maniwa Y, Nishio W, Okita Y, Yoshimura M. Expression of Nectin 3: Novel prognostic marker of lung adenocarcinoma. Thoracic Cancer 2012;3:175-181.
  • Tanaka Y, Shigemura N, Kawamura T, Noda K, Isse K, Stolz DB, Billiar TR, Toyoda Y, Bermudez CA, Lyons-Weiler J, Nakao. Profiling molecular changes induced by hydrogen treatment of lung allografts prior to procurement. Biochem Biophys Res Commun 2012;425:873-9.
  • Tane S, Tanaka Y, Tauchi S, Uchino K, Nakai R, Yoshimura M. Radically resected epithelioid angiosarcoma that originated in the mediastinum. Gen Thorac Cardiovasc Surg 2011;59:503-6.
  • Doi T, Maniwa Y, Tanaka Y, Tane S, Hashimoto S, Ohno Y, Nishio W, Nishimura Y, Ohbayashi C, Okita Y, Hayashi Y, Yoshimura M. MT1-MMP plays an important role in an invasive activity of malignant pleural mesothelioma cell.
  • Wakahara T, ManiwaY, Tanaka Y, Nishio W, Yoshimura M. Successful management of descending necrotizing mediastinitis. Asian Cardiovasc Thoracic Ann 2011;19:228-231.
  • Maniwa Y, Nishio W, Yoshimura M. Application of hRad9 to lung cancer treatment as a molecular marker and a molecular target. Thoracic Cancer 2011;2:7-15.
  • Satoh N, Maniwa Y, Bermudez VP, Nishimura K, Nishio W, Yoshimura M, Okita Y, Ohbayashi C, Hurwitz J, Hayashi Y. Oncogenic Phosphatase Wip1 is a Novel Prognostic Marker for Lung Adenocarcinoma Patient Survival. Cancer Sci 2011;102:1101-1106.
  • Tanaka Y, Maniwa Y, Bermudez VP, Doi T, Nishio W, Ohbayashi C, Okita Y, Hurwitz J, Hayashi Y, Yoshimura M. Non-synonymous SNPs in DNA damage repair pathways and lung cancer risk. Cancer 2010;116:896-902.
  • Maniwa Y, Yoshimura M, Hashimoto S, Takata M, Nishio W. Chemosensitivity of Lung Cancer: Differences between Primary Tumor and Lymph Node Metastasis. Oncology Letters 2010;1:345-349.
  • Nakai R, Maniwa Y, Tanaka Y, Nishio W, Yoshimura M, Okita Y, Ohbayashi C, Satoh N, Ogita H, Takai Y, Hayashi Y. Overexpression of Necl-5 correlates with unfavorable prognosis in patients with lung adenocarcinoma. Cancer Sci 2010;101:1326-1330.
  • Maekawa T, Maniwa Y, Doi T, Okada K, Nishio W, Yoshimura M, Ohbayashi C, Hayashi Y, Okita Y. Expression and localization of FOXO1 in non-small cell lung cancer. Oncol Rep 2009;22:57-64.
  • Maniwa Y, Yoshimura M, Takata M, Nishimura Y, Ohno Y. Effective chemotherapy based on a chemosensitivity test for malignant pleural mesothelioma. Ann Thorac Cardiovasc Surg 2008;14:319-321.
  • Yuki T, Maniwa Y, Doi T, Okada K, Nishio W, Hayashi Y, Okita Y. DNA damage sensor protein hRad9-a novel molecular target for lung cancer treatment. Oncol Rep 2008;20:1047-1052.
  • Tanaka Y, Maniwa Y, Nishio W, Yoshimura M, Okita Y. The optimal timing to resect pulmonary metastasis. Eur J Cardiothorac Surg 2008;3:1135-1138.
  • Takata M, Maniwa Y, Doi T, Tanaka Y, Okada K, Nishio W, Ohbayashi C, Yoshimura M, Hayashi Y, Okita Y. Double-layered collagen gel hemisphere for cell invasion assay: Successful visualization and quantification of cell invasion activity. Cell common adhes 2007;14:157-167.
  • Tanaka Y, Maniwa Y, Yoshimura M, Okita Y. Successful treatment of descending necrotizing mediastinitis. Gen Thorac Cardiovasc Surg 2007;55:366-369.
  • Maniwa Y, Yoshimura M, Bermudez VP, Obayashi C, Hayashi Y, Hurwitz J, Okita Y. The His239Arg SNP of HRAD9 is associated with Lung Adenocarcinoma. Cancer 2006;106:1117-1122.
  • Maniwa Y, Yoshimura M, Bermudez VP, Obayashi C, Hayashi Y, Hurwitz J, Okita Y. Accumulation of hRad9 protein in the nuclei of non-small cell lung cancer (NSCLC) cells. Cancer 2005;103:126-132.
  • Harada N, Maniwa Y, Yoshimura M, Nagata M, Hamada H, Yokono K, Okita Y. E1B-deleted Adenovirus replicates in p53-Deficient Lung Cancer Cells because of the Absence of Apoptosis. Oncol Rep;14:1155-1163.
  • Maniwa Y, Yoshimura M, Obayashi C, Inaba M, Kiyooka K, Kanki M, Okita Y. The association of p53 gene mutation and telomerase activity in resectable non-small cell lung cancer. Chest 2001;120:589-594.

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