研究・業績

当科での研究内容

  • 肺癌細胞における遺伝子,蛋白異常とその臨床的意義についての研究
  • 癌宿主相互作用と癌浸潤のメカニズムの研究
  • 肺癌におけるバイオマーカーの探索
  • 肺癌手術における低侵襲手術の確立
  • 転移性肺腫瘍治療における潜在病巣のコントロール
  • 胸部感染疾患に対する治療戦略
  • 嚢胞性肺疾患の手術における合理的な手技の確立
  • Ex. vivo lung perfusionを用いた新しい臓器保存法の確立

実績

英文

  • Tanaka Y, Hokka D, Ogawa H, Shimizu N, Inoue T, Tanaka H, Okita Y, Maniwa Y. Surgery for malignant lesions of the chest which extensively involved the mediastinum, lung, and heart. Gen Thorac Cardiovasc Surg. 2017;65:365-373.
  • Tauchi S, Sakai Y, Fujimoto S, Ogawa H, Tane S, Hokka D, Tanaka Y, Nishio W, Yoshimura M, Yanagita E, Itoh T, Hayashi Y, Maniwa Y. Psf3 is a prognostic biomarker in lung adenocarcinoma: a larger trial using tissue microarrays of 864 consecutive resections. Eur J Cardiothorac Surg. 2016;50:758-764.
  • Tanaka Y, Tane S, Hokka D, Ogawa H, Maniwa Y. The Use of Oxidized Regenerated Cellulose for Video-Assisted Thoracic Surgery. Ann Thorac Surg. 2016;101:786-8.
  • Hokka D, Ogawa H, Tane S, Tanaka Y, Tauchi S, Maniwa Y. Ruptured thymoma causing a hemothorax: A case report. Oncol Lett. 2015;10:1810-1812.
  • Tane S, Sakai Y, Hokka D, Okuma H, Ogawa H, Tanaka Y, Uchino K, Nishio W, Yoshimura M, Maniwa Y. Significant role of Psf3 expression in non-small-cell lung cancer. Cancer Sci. 2015;106:1625-34.
  • Tane S, Nishio W, Okuma H, Ogawa H, Hokka D, Tane K, Tanaka Y, Uchino K, Yoshimura M, Maniwa Y. Operative outcomes of thoracoscopic lobectomy for non-small-cell lung cancer. Asian Cardiovasc Thorac Ann. 2015;23:950-7
  • Ogawa H, Uchino K, Tanaka Y, Shimizu N, Okuda Y, Tane K, Tauchi S, Nishio W, Maniwa Y, Yoshimura M. Efficacy of adjuvant chemotherapy for lung adenocarcinoma patients with positive pleural lavage cytology findings. Interact Cardiovasc Thorac Surg. 2015;21:34-9.
  • Tomono A, Nakamura T, Otowa Y, Imanishi T, Tanaka Y, Maniwa Y, Kakeji Y. A Case of Benign Esophageal Schwannoma Causing Life-threatening Tracheal Obstruction. Ann Thorac Cardiovasc Surg. 2015;21:289-92.
  • Ogawa H, Uchino K, Tanaka Y, Shimizu N, Okuda Y, Tane K, Hokka D, Tane S, Tauchi S, Nishio W, Maniwa Y, Yoshimura M. Outcomes of segmentectomy for cT1bN0M0 lung adenocarcinoma and squamous cell carcinoma: a possible association with pathological invasion. Eur J Cardiothorac Surg. 2015;48:77-82.
  • Tanaka Y, Noda K, Isse K, Tobita K, Maniwa Y, Bhama JK, D'Cunha J, Bermudez CA, Luketich JD, Shigemura N. A Novel Dual Ex Vivo Lung Perfusion Technique Improves Immediate Outcomes in an Experimental Model of Lung Transplantation. Am J Transplant. 2015;15:1219-30.
  • Hokka D, Uchino K, Tane K, Ogawa H, Tane S, Tanaka Y, Tauchi S, Nishio W, Yoshimura M, Maniwa Y. Pleural lavage cytology as an independent prognostic factor in non-small-cell lung cancer patients with stage I disease and adenocarcinoma. Mol Clin Oncol. 2015 Jan;3:244-248.
  • Tane S, Nishio W, Ogawa H, Hokka D, Tane K, Tanaka Y, Tauchi S, Uchino K, Sakai Y, Ohbayashi C, Yoshimura M, Maniwa Y. Clinical significance of the “not otherwise specified" subtype in candidates for resectable non-small cell lung cancer. Oncol Lett. 2014;8:1017-1024.
  • Tanaka Y, Shigemura N, Noda K, Kawamura T, Isse K, Stolz DB, Bermudez CA.Optimal lung inflation techniques in a rat lung transplantation model: A revisit. Thorac Cardiovasc Surg. 2014;62:427-33.
  • Ogawa H, Tanaka Y, Koma Y, Hokka D, Tane S, Tauchi S, Uchino K, Yoshimura M, Maniwa Y. Pulmonary Large Cell Neuroendocrine Carcinoma showing extensive “pagetoid spread" in the bronchial epithelium. Oncol Lett.2014;8:2621-2623.
  • Noda K, Shigemura N, Tanaka Y, Bhama JK, D'Cunha J, Luketich JD, Bermudez CA. Successful prolonged ex vivo lung perfusion for graft preservation in rats. Eur J Cardiothorac Surg. 2014;45:e54-60.
  • Noda K, Shigemura N, Tanaka Y, Bhama J, D'Cunha J, Kobayashi H, Luketich JD, Bermudez CA. Hydrogen preconditioning during ex vivo lung perfusion improves the quality of lung grafts in rats. Transplantation. 2014;98:499-506
  • Chen X, Hokka D, Maniwa Y, Ohbayashi C, Itoh T, Hayashi Y. Sirt1 is a tumor promoter in lung adenocarcinoma. Oncol Lett. 2014;8:387-393.
  • Seki S, Koyama H, Ohno Y, Nishio M, Takenaka D, Maniwa Y, Itoh T, Nishimura Y, Sugimura K.Diffusion-weighted MR imaging vs. multi-detector row CT: Direct comparison of capability for assessment of management needs for anterior mediastinal solitary tumors. Eur J Radiol. 2014;83:835-42.
  • Tsuboshima K, Wakahara T, Matoba Y, Miyauchi H, Hayashi C, Kobayashi I, Oue H, Watanabe Y, Ono T, Maniwa Y. Single-incision thoracoscopic surgery using a chest wall pulley for lung excision in patients with primary spontaneous pneumothorax. Surg Today. 2015;45:595-9.
  • Tane S, Ohno Y, Hokka D, Ogawa H, Tauchi S, Nishio W, Yoshimura M, Okita Y, Maniwa Y. The efficacy of 320-detector row CT for Assessment of Preoperative Pulmonary Vasculature of Candidates for Pulmonary Segmentectomy. Interact Cardiovasc Thorac Surg. 2013;17:974-80.
  • Hokka D, Maniwa Y, Tane S, Nishio W, Yoshimura M, Okita Y, Ohbayashi C, Sakai Y, Chen X, Hayashi Y. Psf3 is a prognostic biomarker in lung adenocarcinoma. Lung Cancer 2013;79:77-82.
  • Tane S, Maniwa Y, Hokka D, Tauchi S, Nishio W, Okita Y, Yoshimura M. The role of Necl-5 in the invasive activity of lung adenocarcinoma. Exp Mol Pathol 2013;94:330-5.
  • Tanaka Y, Ogawa H, Uchino K, Ohbayashi C, Maniwa Y, Nishio W, Nakao A, Yoshimura M. Immunohistochemical studies of pulmonarylarge cell neuroendocrine carcinoma: a possible association between staining patterns with neuroendocrine markers and tumor response to chemotherapy. J Thorac Cardiovasc Surg 2013;145:839-46.
  • Tane S, Nishio W, Hokka D, Maniwa Y, Yoshimura M. Ewing's sarcoma family of tumors originating in the main bronchus. Thoracic Cancer 2012;3:353-356.
  • Noda K(※), Tanaka Y(※), Shigemura N, Kawamura T, Wang Y, Masutani K, Sun X, Toyoda Y, Bermudez CA, Nakao A, Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration. Transpl Int 2012;25:1213-22 (※)These authors contributed to this work equally.
  • Maniwa Y, Nishio W, Okita Y, Yoshimura M. Expression of Nectin 3: Novel prognostic marker of lung adenocarcinoma. Thoracic Cancer 2012;3:175-181.
  • Tanaka Y, Shigemura N, Kawamura T, Noda K, Isse K, Stolz DB, Billiar TR, Toyoda Y, Bermudez CA, Lyons-Weiler J, Nakao. Profiling molecular changes induced by hydrogen treatment of lung allografts prior to procurement. Biochem Biophys Res Commun 2012;425:873-9.
  • Tane S, Tanaka Y, Tauchi S, Uchino K, Nakai R, Yoshimura M. Radically resected epithelioid angiosarcoma that originated in the mediastinum. Gen Thorac Cardiovasc Surg 2011;59:503-6.
  • Doi T, Maniwa Y, Tanaka Y, Tane S, Hashimoto S, Ohno Y, Nishio W, Nishimura Y, Ohbayashi C, Okita Y, Hayashi Y, Yoshimura M. MT1-MMP plays an important role in an invasive activity of malignant pleural mesothelioma cell.
  • Wakahara T, ManiwaY, Tanaka Y, Nishio W, Yoshimura M. Successful management of descending necrotizing mediastinitis. Asian Cardiovasc Thoracic Ann 2011;19:228-231.
  • Maniwa Y, Nishio W, Yoshimura M. Application of hRad9 to lung cancer treatment as a molecular marker and a molecular target. Thoracic Cancer 2011;2:7-15.
  • Satoh N, Maniwa Y, Bermudez VP, Nishimura K, Nishio W, Yoshimura M, Okita Y, Ohbayashi C, Hurwitz J, Hayashi Y. Oncogenic Phosphatase Wip1 is a Novel Prognostic Marker for Lung Adenocarcinoma Patient Survival. Cancer Sci 2011;102:1101-1106.
  • Tanaka Y, Maniwa Y, Bermudez VP, Doi T, Nishio W, Ohbayashi C, Okita Y, Hurwitz J, Hayashi Y, Yoshimura M. Non-synonymous SNPs in DNA damage repair pathways and lung cancer risk. Cancer 2010;116:896-902.
  • Maniwa Y, Yoshimura M, Hashimoto S, Takata M, Nishio W. Chemosensitivity of Lung Cancer: Differences between Primary Tumor and Lymph Node Metastasis. Oncology Letters 2010;1:345-349.
  • Nakai R, Maniwa Y, Tanaka Y, Nishio W, Yoshimura M, Okita Y, Ohbayashi C, Satoh N, Ogita H, Takai Y, Hayashi Y. Overexpression of Necl-5 correlates with unfavorable prognosis in patients with lung adenocarcinoma. Cancer Sci 2010;101:1326-1330.
  • Maekawa T, Maniwa Y, Doi T, Okada K, Nishio W, Yoshimura M, Ohbayashi C, Hayashi Y, Okita Y. Expression and localization of FOXO1 in non-small cell lung cancer. Oncol Rep 2009;22:57-64.
  • Maniwa Y, Yoshimura M, Takata M, Nishimura Y, Ohno Y. Effective chemotherapy based on a chemosensitivity test for malignant pleural mesothelioma. Ann Thorac Cardiovasc Surg 2008;14:319-321.
  • Yuki T, Maniwa Y, Doi T, Okada K, Nishio W, Hayashi Y, Okita Y. DNA damage sensor protein hRad9-a novel molecular target for lung cancer treatment. Oncol Rep 2008;20:1047-1052.
  • Tanaka Y, Maniwa Y, Nishio W, Yoshimura M, Okita Y. The optimal timing to resect pulmonary metastasis. Eur J Cardiothorac Surg 2008;3:1135-1138.
  • Takata M, Maniwa Y, Doi T, Tanaka Y, Okada K, Nishio W, Ohbayashi C, Yoshimura M, Hayashi Y, Okita Y. Double-layered collagen gel hemisphere for cell invasion assay: Successful visualization and quantification of cell invasion activity. Cell common adhes 2007;14:157-167.
  • Tanaka Y, Maniwa Y, Yoshimura M, Okita Y. Successful treatment of descending necrotizing mediastinitis. Gen Thorac Cardiovasc Surg 2007;55:366-369.
  • Maniwa Y, Yoshimura M, Bermudez VP, Obayashi C, Hayashi Y, Hurwitz J, Okita Y. The His239Arg SNP of HRAD9 is associated with Lung Adenocarcinoma. Cancer 2006;106:1117-1122.
  • Maniwa Y, Yoshimura M, Bermudez VP, Obayashi C, Hayashi Y, Hurwitz J, Okita Y. Accumulation of hRad9 protein in the nuclei of non-small cell lung cancer (NSCLC) cells. Cancer 2005;103:126-132.
  • Harada N, Maniwa Y, Yoshimura M, Nagata M, Hamada H, Yokono K, Okita Y. E1B-deleted Adenovirus replicates in p53-Deficient Lung Cancer Cells because of the Absence of Apoptosis. Oncol Rep;14:1155-1163.
  • Maniwa Y, Yoshimura M, Obayashi C, Inaba M, Kiyooka K, Kanki M, Okita Y. The association of p53 gene mutation and telomerase activity in resectable non-small cell lung cancer. Chest 2001;120:589-594.

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