Publications

2026

Shinjyo N., Shigemura M., & Okabe Y.Control of Mucociliary Clearance in Airway Host DefenseInternational Immunology, dxag034 (2026)　doi: 10.1093/intimm/dxag034（Online ahead of print）　PubMed

Shinjyo N., Kimura H., Yoshihara T., Suzuki J., Yamaguchi M., Kawabata S., & Okabe Y.Aldehyde metabolism governs resilience of mucociliary clearance to air pollution exposureThe Journal of Clinical Investigation, e191276 (2025)
Nakayama Y., Sasai M., Kuratani A., Okamoto M., Okuzaki D., Yamamoto K., Ono C., Yamaguchi M., Kawabata S., Shinjyo N., Okabe Y., Matsuura Y., Ato M., Yamamoto M.Targeted labeling and depletion of alveolar macrophages using VeDTR mouse technology.iScience, 28(3):111975. doi: 10.1016/j.isci.2025.111975 (2025)

Okabe Y.Development and organization of omental milky spotsImmunological Reviews, doi: 10.1111/imr.13337 (2024)
Luca D., Lee S., Hirota K., Okabe Y., Uehori J., Izawa K., Lanz AL., Schütte V., Sivri B., Tsukamoto Y., Hauck F., Behrendt R., Roers A., Fujita T., Nishikomori R., Lee-Kirsch MA., & Kato H.Aberrant RNA sensing in regulatory T cells causes systemic autoimmunityScience Advances, eadk0820. doi: 10.1126/sciadv.adk0820 (2024)

Yoshihara T., & Okabe Y.Aldh1a2+ fibroblastic reticular cells regulate lymphocyte recruitment in omental milky spotsThe Journal of Experimental Medicine, 220(5), e20221813 (2023)

Okabe Y.Immune Niche Within the Peritoneal CavityCurrent Topics in Microbiology and Immunology, 434, 123-134 (2021)

Ohteki T., & Okabe Y.The Origins of Macrophages and Their Roles Beyond ImmunologyInternational Immunology, 30(11), 483-484 (2018)
Okabe Y.Molecular control of the identity of tissue-resident macrophagesInternational Immunology, 30(11), 485-491 (2018)

Okabe Y., & Medzhitov R.Wormhole Travel for MacrophagesCell, 165(3), 518-519 (2016)
Okabe Y., & Medzhitov R.Tissue Biology Perspective on MacrophagesNature Immunology, 17, 9-17 (2016)

Okabe Y., & Medzhitov R.How the immune system spots tumorseLife, 3 (2014)
Okabe Y., & Medzhitov R.Tissue-specific signals control reversible program of localization and functional polarization of macrophagesCell, 157, 832-844 (2014)　【Cell, Best of 2014に選出】

Okabe Y., Sano T.(equal contribution), & Nagata S.Regulation of the innate immune response by threonine-phosphatase of Eyes absentNature, 460, 520-524 (2009)

Okabe Y., Kawane K., & Nagata S.IFN regulatory factor (IRF) 3/7-dependent and –independent gene induction by mammalian DNA that escapes degradationEuropean Journal of Immunology, 38, 3150-3158 (2008)

Nakaya M., Tanaka M., Okabe Y., Hanayama R., & Nagata S.Opposite effects of rho family GTPases on engulfment of apoptotic cells by macrophagesThe Journal of Biological Chemistry, 281, 8836-8842 (2006)

Okabe Y., Kawane K., Akira S., Taniguchi T., & Nagata S.Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradationThe Journal of Experimental Medicine, 202, 1333-1339 (2005)
Yoshida H., Okabe Y.(equal contribution), Kawane K., Fukuyama H., & Nagata S.Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNANature Immunology, 6, 49-56 (2005)

Takahasi K., Suzuki N., Horiuchi M., Mori M., Suhara W., Okabe Y., Fukuhara Y., Terasawa H., Akira S., Fujita T., & Inagaki F.X-ray crystal structure of IRF-3 and its functional implicationsNature Structural & Molecular Biology, 10, 922-927 (2003)

Iwamura T., Yoneyama M., Koizumi N., Okabe Y., Namiki H., Samuel CE., & Fujita T.PACT, a Double-Stranded RNA Binding Protein Acts as a Positive Regulator for Type I Interferon Gene Induced by Newcastle Disease VirusBiochemical and Biophysical Research Communications, 282, 515-523 (2001)
Iwamura T., Yoneyama M., Yamaguchi K., Suhara W., Mori W., Shiota K., Okabe Y., Namiki H., & Fujita T.Induction of IRF-3/-7 kinase and NF-kappaB in response to double-stranded RNA and virus infection: common and unique pathwaysGenes to Cells, 6, 375-388 (2001)