2025
Original Article
Ishihara N, Koma Y, Omori M, Komatsu S, Torigoe R, Yokoo H, Nakanishi T, Yamanaka K, Azumi Y, Tsukamoto S, Kodama T, Nishio M, Shigeoka M, Yokozaki H, Fukumoto T.
Chemokine (C-C Motif) Ligand 2/CCR2/Extracellular Signal-Regulated Kinase Signal Induced through Cancer Cell–Macrophage Interaction Contributes to Hepatocellular Carcinoma Progression.
Am. J. Pathol. 195(3): 589–608, 2025. doi: 10.1016/j.ajpath.2024.12.007
2024
Original Article
Nakanishi T, Koma Y, Miyako S, Torigoe R, Yokoo H, Omori M, Yamanaka K, Ishihara N, Tsukamoto S, Kodama T, Nishio M, Shigeoka M, Yokozaki H, Kakeji Y.
AREG Upregulation in Cancer Cells via Direct Interaction with Cancer-Associated Fibroblasts Promotes Esophageal Squamous Cell Carcinoma Progression Through EGFR-Erk/p38 MAPK Signaling.
Cells 13(20): 1733, 2024. doi: 10.3390/cells13201733
Tsukamoto S, Kodama T, Nishio M, Shigeoka M, Itoh T, Yokozaki H, Koma Y.
Podoplanin Expression in Early-Stage Colorectal Cancer-Associated Fibroblasts and Its Utility as a Diagnostic Marker for Colorectal Lesions.
Cells 13(20): 1682, 2024. doi: 10.3390/cells13201682
Yamanaka K, Koma Y, Urakami S, Takahashi R, Nagamata S, Omori M, Torigoe R, Yokoo H, Nakanishi T, Ishihara N, Tsukamoto S, Kodama T, Nishio M, Shigeoka M, Yokozaki H, Terai Y.
YKL40/Integrin β4 Axis Induced by the Interaction between Cancer Cells and Tumor-Associated Macrophages Is Involved in the Progression of High-Grade Serous Ovarian Carcinoma.
Int. J. Mol. Sci. 25(19): 10598, 2024. doi: 10.3390/ijms251910598
Miyako S, Koma Y, Nakanishi T, Tsukamoto S, Yamanaka K, Ishihara N, Azumi Y, Urakami S, Shimizu M, Kodama T, Nishio M, Shigeoka M, Kakeji Y, Yokozaki H.
Periostin in Cancer-Associated Fibroblasts Promotes Esophageal Squamous Cell Carcinoma Progression by Enhancing Cancer and Stromal Cell Migration.
Am. J. Pathol. 194(5): 828–848, 2024. doi: 10.1016/j.ajpath.2023.12.010
Short Communication
Nishio M, Tsukamoto S, Kodama T, Shigeoka M, Koma Y, Yokozaki H.
Pseudoimmunofluorescent immunohistochemistry image analysis of phosphorylated signaling proteins in human esophageal squamous cell carcinoma tissue.
Pathol. Int. 74(3): 139–145, 2024. doi: 10.1111/pin.13407
Case Report
Tsukamoto S, Kozuki A, Kaneda K, Ichikawa C, Imai Y.
A Case of Intracholecystic Papillary Neoplasm Extending Through a Cholecysto-Colonic Fistula.
Cureus 16 (11) e72854. doi: 10.7759/cureus.72854
Kodama T, Shigeoka M, Nishio M, Koma Y, Akashi M, Yokozaki H.
Colostomy‐site carcinoma with primitive phenotype in a rectal cancer patient after achieving pathological complete response with neoadjuvant chemoradiotherapy.
Pathol. Int. 74(1): 33–38, 2024. doi: 10.1111/pin.13396
Kodama T, Tani A, Yamane H, Itoh T.
A case of pancreatic ductal adenocarcinoma with enteroblastic, neuroendocrine, and squamous differentiation with p53 overexpression and loss of Rb expression.
Int. J. Surg. Case Rep. 120 (2024) 109854. doi: 10.1016/j.ijscr.2024.109854
Review Article
重岡 学
口腔細胞診のperspective ―口腔癌の早期診断に向けた多職種連携の重要性―
日臨細胞近畿連合会誌 32: 3–14, 2024.
2023
Original Article
Azumi Y, Koma Y, Tsukamoto S, Kitamura Y, Ishihara N, Yamanaka K, Nakanishi T, Miyako S, Urakami S, Tanigawa K, Kodama T, Nishio M, Shigeoka M, Kakeji Y, Yokozaki H.
IFI16 Induced by Direct Interaction between Esophageal Squamous Cell Carcinomas and Macrophages Promotes Tumor Progression via Secretion of IL-1α.
Cells 12(22): 2603, 2023. doi: 10.3390/cells12222603
Urakami S, Koma Y, Tsukamoto S, Azumi Y, Miyako S, Kitamura Y, Kodama T, Nishio M, Shigeoka M, Abe H, Usami Y, Kodama Y, Yokozaki H.
Biological and clinical significance of the YKL-40/osteopontin–integrin β4–p70S6K axis induced by macrophages in early oesophageal squamous cell carcinoma.
J. Pathol. 261(1): 55–70, 2023. doi: 10.1002/path.6148
Tsukamoto S, Koma Y, Kitamura Y, Tanigawa K, Azumi Y, Miyako S, Urakami S, Hosono M, Kodama T, Nishio M, Shigeoka M, Yokozaki H.
Matrix Metalloproteinase 9 Induced in Esophageal Squamous Cell Carcinoma Cells via Close Contact with Tumor-Associated Macrophages Contributes to Cancer Progression and Poor Prognosis.
Cancers 15(11): 2987, 2023. doi: 10.3390/cancers15112987
Kitamura Y, Koma Y, Tanigawa K, Tsukamoto S, Azumi Y, Miyako S, Urakami S, Kodama T, Nishio M, Shigeoka M, Kakeji Y, Yokozaki H.
Roles of IL-7R Induced by Interactions between Cancer Cells and Macrophages in the Progression of Esophageal Squamous Cell Carcinoma.
Cancers 15(2): 394, 2023. doi: 10.3390/cancers15020394
Short Communication
Kodama T, Kanzawa M, Hasegawa H, Tsukamoto S, Nishio M, Shigeoka M, Koma Y, Itoh T, Yokozaki H.
The significance of intratumoural CD163+ macrophages in oral malignant melanoma: A preliminary study.
Oral Diseases 29(5): 2061–2065, 2023. doi: 10.1111/odi.14252
2022
Original Article
Tanigawa K, Tsukamoto S, Koma Y, Kitamura Y, Urakami S, Shimizu M, Fujikawa M, Kodama T, Nishio M, Shigeoka M, Kakeji Y, Yokozaki H.
S100A8/A9 Induced by Interaction with Macrophages in Esophageal Squamous Cell Carcinoma Promotes the Migration and Invasion of Cancer Cells via Akt and p38 MAPK Pathways.
Am. J. Pathol. 192(3): 536–552, 2022. doi: 10.1016/j.ajpath.2021.12.002
2021
Original Article
Shimizu M, Koma Y, Sakamoto H, Tsukamoto S, Kitamura Y, Urakami S, Tanigawa K, Kodama T, Higashino N, Nishio M, Shigeoka M, Kakeji Y, Yokozaki H.
Metallothionein 2A Expression in Cancer-Associated Fibroblasts and Cancer Cells Promotes Esophageal Squamous Cell Carcinoma Progression.
Cancers 13(18): 4552, 2021. doi: 10.3390/cancers13184552
Ichihara Y, Yokozaki H.
Close Association of Intraepithelial Accumulation of M2-Skewed Macrophages with Neoplastic Epithelia of the Esophagus.
Kobe J. Med. Sci. 67(1): E18-E33, 2021.
Journal URL:https://www.med.kobe-u.ac.jp/journal/contents.html
Shigeoka M, Koma Y, Kodama T, Nishio M, Akashi M, Yokozaki H.
Tongue Cancer Cell-Derived CCL20 Induced by Interaction With Macrophages Promotes CD163 Expression on Macrophages.
Front. Oncol. 11:667174, 2021. doi: 10.3389/fonc.2021.667174
Fujikawa M, Koma YI, Hosono M, Urakawa N, Tanigawa K, Shimizu M, Kodama T, Sakamoto H, Nishio M, Shigeoka M, Kakeji Y, Yokozaki H.
Chemokine (C-C Motif) Ligand 1 Derived from Tumor-Associated Macrophages Contributes to Esophageal Squamous Cell Carcinoma Progression via CCR8-Mediated Akt/Proline-Rich Akt Substrate of 40 kDa/Mammalian Target of Rapamycin Pathway.
Am. J. Pathol. 191(4): 686–703, 2021. doi: 10.1016/j.ajpath.2021.01.004
Review Article
Shigeoka M, Koma Y, Nishio M, Akashi M, Yokozaki H.
Alteration of Macrophage Infiltrating Compartment: A Novel View on Oral Carcinogenesis.
Pathobiology May 7:1–11, 2021. doi: 10.1159/000515922
2020
Original Article
Sakamoto H, Koma Y, Higashino N, Kodama T, Tanigawa K, Shimizu M, Fujikawa M, Nishio M, Shigeoka M, Yokozaki H.
PAI-1 derived from cancer-associated fibroblasts in esophageal squamous cell carcinoma promotes the invasion of cancer cells and the migration of macrophages.
Lab. Invest. 101(3): 353–368, 2021. doi: 10.1038/s41374-020-00512-2
Shigeoka M, Koma YI, Kanzawa M, Akashi M, Yokozaki H.
Intraepithelial macrophage expressing CD163 is a histopathological clue to evaluate the malignant potency of oral lichenoid condition: A case report and immunohistochemical investigation.
Diagnostics 2020; 10(9): 624; doi: 10.3390/diagnostics10090624
Kodama T, Koma Y, Arai N, Kido A, Urakawa N, Nishio M, Shigeoka M, Yokozaki H.
CCL3-CCR5 axis contributes to progression of esophageal squamous cell carcinoma by promoting cell migration and invasion via Akt and ERK pathways.
Lab. Invest. 100: 1140–1157, 2020. doi: 10.1038/s41374-020-0441-4
Shigeoka M, Koma YI, Kodama T, Nishio M, Akashi M, Yokozaki H.
CD163+ Foamy Macrophages Are Associated with the Morphogenesis of Oral Verruciform Xanthoma through Angiogenesis by VEGF Expression: An Immunohistochemical Study.
Dentistry Journal 8(1): 18, 2020. doi: 10.3390/dj8010018
Okamoto M, Koma Y, Kodama T, Nishio M, Shigeoka M, Yokozaki H.
Growth Differentiation Factor 15 Promotes Progression of Esophageal Squamous Cell Carcinoma via TGF-β Type II Receptor Activation.
Pathobiology Jan 2:1–14, 2020. doi: 10.1159/000504394
2019
Original Article
Shigeoka M, Koma YI, Kodama T, Nishio M, Akashi M, Yokozaki H.
Intraepithelial CD163+ macrophages in tongue leukoplakia biopsy: A promising tool for cancer screening.
Oral Diseases 26(3): 527–536, 2020. doi: 10.1111/odi.13269
Shigeoka M, Koma Y, Nishio M, Komori T, Yokozaki H.
CD163+ macrophages infiltration correlates with the immunosuppressive cytokine interleukin 10 expression in tongue leukoplakia.
Clinical and Experimental Dental Research 5(6): 627–637, 2019. doi: 10.1002/cre2.228
Kodaira H, Koma Y, Hosono H, Higashino N, Suemune K, Nishio M, Shigeoka M, Yokozaki H.
ANXA10 induction by interaction with tumor-associated macrophages promotes the growth of esophageal squamous cell carcinoma.
Pathol. Int. 69(3): 135–147, 2019. doi: 10.1111/pin.12771
Higashino N, Koma Y, Hosono M, Takase N, Okamoto M, Kodaira H, Nishio M, Shigeoka M, Kakeji Y, Yokozaki H.
Fibroblast activation protein-positive fibroblasts promote tumor progression through secretion of CCL2 and interleukin-6 in esophageal squamous cell carcinoma.
Lab. Invest. 99(6): 777–792, 2019. doi: 10.1038/s41374-018-0185-6
2018
Review Article
Yokozaki H, Koma Y, Shigeoka M, Nishio M.
Cancer as a tissue: The significance of cancer-stromal interactions in the development, morphogenesis and progression of human upper digestive tract cancer.
Pathol. Int. 68(6): 334–352, 2018. doi: 10.1111/pin.12674
CPC解説
平社亜沙子，毛利太郎，大谷恭子，西尾真理，渡部俊介，立花久嗣，横崎 宏
視機能障害を主訴に発症した中枢神経アスペルギルス症の一剖検例
病理と臨床 36(3): 271–275, 2018.
2017
Original Article
Hosono M, Koma Y, Takase N, Urakawa N, Higashino N, Suemune K, Kodaira H, Nishio M, Shigeoka M, Kakeji Y, Yokozaki H.
CXCL8 derived from tumor-associated macrophages and esophageal squamous cell carcinomas contributes to tumor progression by promoting migration and invasion of cancer cells.
Oncotarget 8(62): 106071–106088, 2017. doi: 10.18632/oncotarget.22526
Review Article
狛雄一朗，西尾真理，重岡 學，横崎 宏
食道扁平上皮癌の進展や発がん初期段階におけるマクロファージの解析
別冊BIO Clinica 消化管の慢性炎症 6(3): 123–127, 2017.
2016
Original Article
Hashimoto O, Yoshida M, Koma YI, Yanai T, Hasegawa D, Kosaka Y, Nishimura N, Yokozaki H.
Collaboration of cancer-associated fibroblasts and tumour-associated macrophages for neuroblastoma development.
J. Pathol. 240(2): 211–223, 2016. doi: 10.1002/path.4769
Takase N, Koma YI, Urakawa N, Nishio M, Arai N, Akiyama H, Shigeoka M, Kakeji Y, Yokozaki H.
NCAM- and FGF-2-mediated FGFR1 signaling in the tumor microenvironment of esophageal cancer regulates the survival and migration of tumor-associated macrophages and cancer cells.
Cancer Lett. 380(1): 47–58, 2016. doi: 10.1016/j.canlet.2016.06.009
Nishio M, Urakawa N, Shigeoka M, Takase N, Ichihara Y, Arai N, Koma Y, Yokozaki H.
Software-assisted morphometric and phenotype analyses of human peripheral blood monocyte-derived macrophages induced by a microenvironment model of human esophageal squamous cell carcinoma.
Pathol. Int. 66(2): 83–93, 2016. doi: 10.1111/pin.12381
Review Article
横崎 宏，狛雄一朗，重岡 學，西尾真理
【慢性炎症とがん】 がん微小環境とがんの増殖・浸潤・転移 消化管がんの進展とがん間質
別冊BIO Clinica 慢性炎症と疾患 5(1): 77–81, 2016.
2015
Original Article
Urakawa N, Utsunomiya S, Nishio M, Shigeoka M, Takase N, Arai N, Kakeji Y, Koma Y, Yokozaki H.
GDF15 derived from both tumor-associated macrophages and esophageal squamous cell carcinomas contributes to tumor progression via Akt and Erk pathways.
Lab. Invest. 95(5): 491–503, 2015. doi: 10.1038/labinvest.2015.36
Shigeoka M, Urakawa N, Nishio M, Takase N, Utsunomiya S, Akiyama H, Kakeji Y, Komori T, Koma Y, Yokozaki H.
Cyr61 promotes CD204 expression and the migration of macrophages via MEK/ERK pathway in esophageal squamous cell carcinoma.
Cancer Med. 4(3): 437–446, 2015. doi: 10.1002/cam4.401
2014
Review Article
横崎 宏，仙波秀峰
消化管がん間質の特徴
病理と臨床 32(1): 51–56, 2014.
2013
Original Article
Shigeoka M, Urakawa N, Nakamura T, Nishio M, Watajima T, Kuroda D, Komori T, Kakeji Y, Semba S, Yokozaki H.
Tumor associated macrophage expressing CD204 is associated with tumor aggressiveness of esophageal squamous cell carcinoma.
Cancer Sci. 104(8): 1112–1119, 2013. doi: 10.1111/cas.12188
2012
Original Articles
Nishimura K, Semba S, Aoyagi K, Sasaki H, Yokozaki H.
Mesenchymal stem cells provide an advantageous tumor microenvironment for the restoration of cancer stem cells.
Pathobiology 79(6): 290–306, 2012.
Yusra, Semba S, Yokozaki H.
Biological significance of tumor budding at the invasive front of human colorectal carcinoma cells.
Int. J. Oncol. 41(1): 201–210, 2012.
Tanaka S, Morita Y, Fujita T, Yokozaki H, Obata D, Fujiwara S, Wakahara C, Masuda A, Sugimoto M, Sanuki T, Yoshida M, Toyonaga T, Kutsumi H, Azuma T.
Clinicopathological characteristics of abnormal micro-lesions at the oro-hypopharynx detected by a magnifying narrow band imaging system.
Dig. Endosc. 24(2): 100–109, 2012.
Review Article
仙波秀峰
胃癌細胞と線維芽細胞・間葉系幹細胞の相互作用
胃がんperspective 5(1): 14–23, 2012.
2011
Original Articles
Watanabe T, Semba S, Yokozaki H.
Regulation of PTEN expression by the SWI/SNF chromatin-remodelling protein BRG1 in human colorectal carcinoma cells.
Br. J. Cancer 104(1): 146–154, 2012.
Hashimoto O, Shimizu K, Semba S, Chiba S, Ku Y, Yokozaki H, Hori Y.
Hypoxia induces tumor aggressiveness and the expansion of CD133-positive cells in a hypoxia-inducible factor-1α-dependent manner in pancreatic cancer cells.
Pathobiology 78(4): 181–192, 2011.
Funakoshi Y, Matsuoka H, Yamamoto K, Yakushijin K, Inui Y, Okamura A, Takeuchi M, Yokozaki H, Minami H.
Therapy-related pure erythroid leukemia with hepatic infiltration and hemophagocytic syndrome.
Intern. Med. 50(24): 3031–3035, 2011.
Review Article
横崎 宏，仙波秀峰
多発胃癌の病理学的特徴 分子病理学的立場から
胃と腸 46(1): 23–29, 2011.
2010
Original Articles
Semba S, Mizuuchi E, Yokozaki H.
Requirement of phosphatase of regenerating liver-3 for the nucleolar localization of nucleolin during the progression of colorectal carcinoma.
Cancer. Sci. 101(10): 2254–2261, 2010.
Maeda N, Semba S, Nakayama S, Yanagihara K, Yokozaki H.
Loss of WW domain-containing oxidoreductase expression in the progression and development of gastric carcinoma: clinical and histopathologic correlations.
Virchows Arch. 457(4): 423–432, 2010.
Matsukawa Y, Semba S, Kato H, Koma Y, Yanagihara K, Yokozaki H.
Constitutive suppression of PRL-3 inhibits invasion and proliferation of gastric cancer cell in vitro and in vivo.
Pathobiology 77(3): 155–162, 2010.
Masuda R, Semba S, Mizuuchi E, Yanagihara K, Yokozaki H.
Negative regulation of the tight junction protein tricellulin by snail-induced epithelial-mesenchymal transition in gastric carcinoma cells.
Pathobiology 77(2): 106–113, 2010.
Wakahashi K, Shimoyama M, Katayama Y, Minagawa K, Yoshida K, Sasaki R, Nakayama S, Yokozaki H, Yanagita E, Itoh T, Hayashi Y, Matsui T.
Histiocytic sarcoma with two immunohistopathologically distinct populations.
Int. J. Hematol. 92(4): 642–646, 2010.
Morioka I, Fujibayashi H, Enoki E, Yokoyama N, Yokozaki H, Matsuo M.
Congenital pneumonia with sepsis caused by intrauterine infection of Ureaplasma parvum in a term newborn: a first case report.
J. Perinatol. 30(5): 359–362, 2010.
Book
横崎 宏，仙波秀峰
増殖因子：改訂版 新編スキルス胃癌 基礎と臨床．
曽和融生，井藤久雄（編），医薬ジャーナル社 p.131–136. 2010.
2009
Original Articles
Nakayama, S., Semba, S., Maeda, N., Matsushita, M., Kuroda, Y. and Yokozaki, H.
Hypermethylation-mediated reduction of WWOX expression in intraductal papillary mucinous neoplasms of the pancreas.
Br. J. Cancer 100(9): 1438–1443, 2009.
Omori, Y., Nakayama, F., Li, D., Kanemitsu, K., Semba, S., Ito, A. and Yokozaki, H.
Alternative lengthening of telomeres frequently occurs in mismatch repair system-deficient gastric carcinoma.
Cancer Sci. 100(3): 413–418, 2009.
Mizuuchi, E., Semba, S., Kodama, Y. and Yokozaki, H.
Down-modulation of keratin 8 phosphorylation levels by PRL-3 contributes to colorectal carcinoma progression.
Int. J. Cancer 124(8):1802–1810, 2009.
Semba, S., Satake, S., Matsushita, M. and Yokozaki, H.
Phosphatase activity of nuclear PTEN is required for CDX2-mediated intestinal differentiation of gastric carcinoma.
Cancer Lett. 274(1): 143–150, 2009.
2008
Original Articles
Semba, S., Yasujima, H., Takano, T. and Yokozaki, H.
Autopsy case of the neonatal form of carnitine palmitoyltransferase-II deficiency triggered by a novel disease-causing mutation del1737C.
Pathol. Int. 58(7): 436–441, 2008.
Nakayama, F., Semba, S., Usami, Y., Chiba, H., Sawada, N. and Yokozaki, H.
Hypermethylation-modulated downregulation of claudin-7 expression promotes the progression of colorectal carcinoma.
Pathobiology 75(3): 177–185, 2008.
Usami, Y., Satake, S., Nakayama, F., Matsumoto, M., Ohnuma, K., Komori, T., Semba, S., Ito, A., and Yokozaki, H.
Snail-associated epithelial-mesenchymal transition promotes oesophageal squamous cell carcinoma motility and progression.
J. Pathol. 215(3): 330–339, 2008.
Semba, S., Hasuo, T., Satake, S., Nakayama, F. and Yokozaki, H.
Prognostic significance of intestinal claudins in high-risk synchronous and metachronous multiple gastric epithelial neoplasias after initial endoscopic submucosal dissection.
Pathol. Int. 58(6): 371–377, 2008.
Koma, Y., Furuno, T., Hagiyama, M., Hamaguchi, K., Nakanishi, M., Masuda, M., Hirota, S., Yokozaki, H. and Ito, A.
Cell adhesion molecule 1 is a novel pancreatic-islet cell adhesion molecule that mediates nerve-islet cell interactions.
Gastroenterology 134(5): 1544–1554, 2008.
Nakayama S, Semba S, Maeda N, Aqeilan RI, Huebner K. and Yokozaki H.
Role of the WWOX gene, encompassing fragile region FRA16D, in suppression of pancreatic carcinoma cells.
Cancer Sci. 99(7): 1370–1376, 2008.
and others...