腫瘍・血液内科について

Funakoshi Y, Yakushijin K, Ohji G, Hojo W, Sakai H, Takai R, Nose T, Ohata S, Nagatani Y, Koyama T, Kitao A, Nishimura M, Imamura Y, Kiyota N, Harada K, Tanaka Y, Mori Y, Minami H. Safety and immunogenicity of the COVID-19 vaccine BNT162b2 in patients undergoing chemotherapy for solid cancer. J Infect Chemother 2022 Apr;28(4):516-520. doi: 10.1016/j.jiac.2021.12.021.

Imamura Y, Kiyota N, Tahara M, Hanai N, Asakage T, Matsuura K, Ota I, Saito Y, Yokota T, Sano D, Kodaira T, Motegi A, Yasuda K, Takahashi S, TanakaK, Onoe T, Okano S, Ariizumi Y, Homma A. Systemic therapy for salivary gland malignancy: current status and future perspectives. Jpn J Clin Oncol 2022 Apr 6;52(4):293-302. doi: 10.1093/jjco/hyac008.

Imamura Y, Otsui K, Mori K, Kitagawa K, Okada S, Hata A, Hayashi H, Nose T, Ohata S, Miyata Y, Funakoshi Y, Toyoda M, Kiyota N, Yakushijin K, Matsuoka H, Minami H. Apixaban in Japanese patients with cancer-associated venous thromboembolism: a phase II Trial. Int J Hematol 2022 Apr;115(4):499-507. doi: 10.1007/s12185-022-03289-w.

Funakoshi Y, Yakushijin Ohji G, Hojo W, Sakai H, Watanabe M, Saeki M, Hirakawa Y, Sakai R, Matsumoto S, Mizutani Y, Kitao A, Miyata Y, Saito Y, Kawamoto S, Yamamoto K, Ito M, Nishimura M, Imamura Y, Kiyota N, Matsuoka H, Mori Y, Minami H. Limited Increase in Antibody Titers following mRNA SARS-CoV-2 Vaccination for More than 3 Years after Final Dose of Anti-CD20 Antibody. 2022 Jan;115(1):7-10. doi: 10.1007/s12185-021-03247-y.

Kobayashi Y, Oh I, Miyamoto T, Lee W-S, Iida H, Minami H, Maeda Y, Jang JH, Yoon S-S, Yeh S-P, Tran Q, Morris J, Franklin J, Kiyoi H. Efficacy and safety of blinatumomab: post hoc pooled analysis in Asian adults with relapsed/refractory B-cell precursor acute lymphoblastic leukemia. Asian-Pacific J Clin Oncol.2022 Jun;18(3):311-318. doi: 10.1111/ajco.13609.

Morita S, Minami H, Mitsuma A, Toyoda M, Kiyota N, Ando Y. A phase I study of LCL161, a novel oral pan-inhibitor of apoptosis protein (IAP) antagonist, in Japanese patient with advanced solid tumors. Asan Pacifi J Clin Oncol.2022 Jan 30. doi: 10.1111/ajco.13744.

Tanizaki J, Yonemori K, Akiyoshi K, Minami H, Ueda H, Takiguchi Y, Kondoh C, Segawa Y, Takahashi S, Iwamoto Y, Kidera Y, Fukuoka K, Ito A, Chiba Y, Nishio K, Nakagawa K, Hyashi H. Open-label phase II study of the efficacy of nivolumab for cancer of unknown primary. Ann Oncol.2022 Feb;33(2):216-226. doi: 10.1016/j.annonc.2021.11.009.

Watanabe M, Yakushijin K, Funakoshi Y, Ohji G, Sakai H, Hojo W, Saeki M, Hirakawa Y, Matsumoto S, Sakai R, Kitao A, Miyata Y, Koyama T, Ito M, Murayama T, Matsuoka H, Minami H. Safety and immunogenicity of BNT162b2 mRNA COVID-19 vaccine in Japanese patients after allogeneic stem cell transplantation. Vaccines. 2022 Jan 21;10(2):158. doi: 10.3390/vaccines10020158.

Kiyota N, Tahara M, Mizusawa J, Kodaira T, Fujii H, Yamazaki T, Mitani H, Iwae S, Fujimoto Y, Onozawa Y, Hanai N, Ogawa T, Hara H, Monden N, Shimura E, Minami S, Fujii T, Tanaka K, Homma A, Yoshimoto S, Oridate N, Omori K, Ueda T, Okami K, Ota I, Shiga K, Sugasawa M, Asakage T, Saito Y, Murono S, Nishimura Y, Nakamura K, Hayashi R; Head and Neck Cancer Study Group of the Japan Clinical Oncology Group (JCOG-HNCSG). Weekly Cisplatin Plus Radiation for Postoperative Head and Neck Cancer (JCOG1008): A Multicenter, Noninferiority, Phase II/III Randomized Controlled Trial. J Clin Oncol.2022 Mar 1;JCO2101293. doi: 10.1200/JCO.21.01293.

Ishii R, Ohkoshi A, Kiyota N, Matsuura K, Yasuda K, Imamura Y, Saito Y, Homma A; Japan Clinical Oncology Group (JCOG) Head and Neck Cancer Study Group. Management of elderly patients with head and neck cancer. Jpn J Clin Oncol. 2022 Apr 6;52(4):313-321. doi: 10.1093/jjco/hyac013.

Singer S, Hammerlid E, Tomaszewska IM, Amdal CD, Bjordal K, Herlofson BB, Santos M, Silva JC, Mehanna H, Fullerton A, Brannan C, Gonzalez LF, Inhestern J, Pinto M, Arraras JI, Yarom N, Bonomo P, Baumann I, Galalae R, Nicolatou-Galitis O, Kiyota N, Raber-Durlacher J, Salem D, Fabian A, Boehm A, Krejovic-Trivic S, Chie WC, Taylor K, Simon C, Licitra L, Sherman AC; EORTC Quality of Life Group and the EORTC Head and Neck Cancer Group. Methodological approach for determining the Minimal Important Difference and Minimal Important Change scores for the European Organisation for Research and Treatment of Cancer Head and Neck Cancer Module (EORTC QLQ-HN43) exemplified by the Swallowing scale. Qual Life Res.2022 Mar;31(3):841-853. doi: 10.1007/s11136-021-02939-6.

Yamamoto K, Kurata K, Kitao A, Sakai R, Matsumoto S, Matsumoto H, Saegusa J, Yakushijin K, Minami H. Cryptic insertion of CBFB into MYH11 leading to a type D fusion in acute myeloid leukemia with normal karyotype. International Journal of Laboratory Hematology 44: e36-e39, 2022.

Tanaka H, Kitao A, Minami H, Hirata K. Marked recovery of cardiac function by chemotherapy and autologous stem cell transplantation of a patient with heart failure with preserved ejection fraction due to primary amyloid light-chain amyloidosis: a case report. Eur Heart J Case Rep 13: 6 (3): ytac016, 2022 (doi: 10.1093/ehjcr/ytac016)

Nose T, Funakoshi Y, Suto H, Nagatani Y, Imamura Y, Toyoda M, Kiyota N, Minami H. Transition of the PD-1 occupancy of nivolumab on T cells after discontinuation and response of nivolumab re-challenge. Molecular and Clin Oncol 16(5):104, 2022 (doi: 10.3892/mco.2022.2537)

Milano G, Innocenti F, Minami H. Liposomal irinotecan (OnivydeTM): Exemplifying the benefits of nanotherapeutic drugs. Cancer Sci 113: 222-2231, 2022 (doi: 10.1111/cas.15377)

Ozaki Y, Tsurutani J, Mukohara T, Iwasa T, Takahashi M, Masuda N, Futamura M, Minami H, Matsumoto K, Kawabata H, Kitano S, Yoshimura K, Takano T. Safety and efficacy of nivolumab plus bevacizumab, paclitaxel for HER2-negative metastatic breast cancer: primary results and biomarker data from a phase 2 trial. Eur J Cancer 171:193-202, 2022

Goto H, Ogawa C, Iida H, Horibe K, Oh I, Takada S, Maeda Y, Minami H, Nakashima Y, Morris JD, Kormany W, Chen Y, Miyamoto T. Safety and efficacy of blinatumomab in Japanese adult and pediatric patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia: final results from an expansion cohort. Acta Hematologica 145 (6): 592-602, 2022 (doi: 10.1159/000525835)

Funakoshi Y, Yakushijin K, Ohji G, Hojo W, Sakai H, Watanabe M, Kitao A, Miyata Y, Saito Y, Kawamoto S, Yamamoto K, Ito M, Koyama T, Imamura Y, Kiyota N, Matsuoka H, Mori Y, Minami H. Promising efficacy of a third dose of mRNA SARS-CoV-2 vaccination in patients treated with anti-CD20 antibody who failed 2-dose vaccination. Vaccines 2022 Jun 17;10(6):965. doi: 10.3390/vaccines10060965.

Inase A, Maimaitili Y, Kimbara S, Mizutani Y, Miyata Y, Ohata S, Matsumoto H, Kitao A, Sakai R, Kawaguchi K, Higashime A, Nagao S, Kurata K, Goto H, Kawamoto S, Yakushijin K, Minami H, Hiroshi Matsuoka. GSK3 inhibitor enhances gemtuzumab ozogamicin-induced apoptosis in primary human leukemia cells by overcoming multiple mechanisms of resistance eJHaem 2022 Dec 12;4(1):153-164. doi: 10.1002/jha2.600.

Shimoyama R, Imamura Y, Uryu K, Mase T, Fujimura Y, Hayashi M, Ohtaki m, Ohtani K, Shinozaki N, Minami H. Real-world outcomes of systemic therapy in Japanese patients with cancer (Tokushukai REAl-world Data project: TREAD): study protocol for a nationwide cohort study. Healthcare .2022 Oct 28;10(11):2146. doi: 10.3390/healthcare10112146.

Okamoto A, Funakoshi Y, Oe M, Takai R, Suto H, Nagatani Y, Nishimura M, Imamura Y, Kunihisa T, Kiyota N, Miki K, Ohe K, Tanino H, Identification of Breast Cancer Stem Cells Using a Newly Developed Long-acting Fluorescence Probe, C5S-A, Targeting ALDH1A1.Anticancer Res. 2022 Mar;42(3):1199-1205. doi: 10.21873/anticanres.15586.

Goto H, Yakushijin K, Adachi Y, Matsumoto H, Yamamoto K, Matsumoto S, Higashime A, Kawaguchi K, Kurata K, Matsuoka H, Minami H. A Pathogenic NRAS c.38G>A(p.G13D) Mutation in RARA Translocation-negative Acute Promyelocytic-like Leukemia with Concomitant Myelodysplastic Syndrome.Intern Med. 2023 May1;62(9):1329-1334. doi: 10.2169/internalmedicine.0174-22. Epub 2022 Sep 21.

Watanabe M, Yakushijin K, Funakoshi Y, Ohji G, Ichikawa H, Sakai H, Hojo W, Saeki M, Hirakawa Y, Matsumoto S, Sakai R, Nagao S, Kitao A, Miyata Y, Koyama T, Saito Y, Kawamoto S, Yamamoto K, Ito M, Murayama T, Matsuoka H, Minami A Third Dose COVID-19 Vaccination in Allogeneic Hematopoietic Stem Cell Transplantation Patients.Vaccines (Basel). 2022 Oct 29;10(11):1830. doi: 10.3390/vaccines10111830.

Watanabe M, Yakushijin K, Tanaka H, Chijiki R, Saeki M, Hirakawa Y, Takakura H, Usui Y, Sakai R, Matsumoto S, Mizutani Y, Kitao A, Nagao S, Miyata Y, Saito Y, Kawamoto S, Yamamoto K, Ito M, Matsuoka H, MinamiH. Global longitudinal strain is superior to ejection fraction for long-term follow-up after allogeneic hematopoietic stem cell transplantation.EJHaem. 2022 Nov 7;4(1):192-198. doi: 10.1002/jha2.586. eCollection 2023 Feb.

Watanabe M, Yakushijin K, Funakoshi Y, Ohji G, Hojo W, Sakai H, Saeki M, Hirakawa Y, Matsumoto S, Sakai R, Nagao S, Kitao A, Miyata Y, Koyama T, Saito Y, Kawamoto S, Ito M, Murayama T, Matsuoka H, Minami H. The Safety and Immunogenicity of the BNT162b2 mRNA COVID-19 Vaccine in Japanese Patients after Allogeneic Stem Cell Transplantation.Vaccines (Basel). 2022 Jan 21;10(2):158. doi: 10.3390/vaccines10020158.

Kiyota N, Tahara M, Robinson B, Schlumberger M, Sherman SI, Leboulleux S, Lee EK, Suzuki T, Ren M, Fushimi K, Wirth LJ. Impact of baseline tumor burden on overall survival in patients with radioiodine-refractory differentiated thyroid cancer treated with lenvatinib in the SELECT global phase 3 trial. Cancer. 2022 Jun 15;128(12):2281-2287. doi: 10.1002/cncr.34181. Epub 2022 Apr 5.

Okumura S, Ishihara M, Kiyota N, Yakushijin K, Takada K, Kobayashi S, Ikeda H, Endo M, Kato K, Kitano S, Matsumine A, Nagata Y, Kageyama S, Shiraishi T, Yamada T, Horibe K, Takesako K, Miwa H, Watanabe T, Miyahara Y, Shiku H. Chimeric antigen receptor T-cell therapy targeting a MAGE A4 peptide and HLA-A*02:01 complex for unresectable advanced or recurrent solid cancer: protocol for a multi-institutional phase 1 clinical trial.BMJ Open. 2022 Nov 14;12(11):e065109. doi: 10.1136/bmjopen-2022-065109.

Higashiyama T, Sugino K, Hara H, Ito KI, Nakashima N, Onoda N, Tori M, Katoh H, Kiyota N, Ota I, Suganuma N, Hibi Y, Nemoto T, Takahashi S, Yane K, Ioji T, Kojima S, Kaneda H, Sugitani I, Tahara M. Phase II study of the efficacy and safety of lenvatinib for anaplastic thyroid cancer (HOPE) Eur J Cancer. 2022 Sep:173:210-218. doi: 10.1016/j.ejca.2022.06.044. Epub 2022 Aug 3.

Otsuka H, Fukumoto T, Kiyota N, Takemori C, Jimbo H, Nishigori C. Severe and delayed-onset acneiform eruptions as an adverse reaction to regorafenib.Dermatol Reports. 2022 Jan 1;14(2):9303. doi: 10.4081/dr.2022.9303. eCollection 2022 Jun 16.

Saito Y, Homma A, Kiyota N, Tahara M, Hanai N, Asakage T, Matsuura K, Ota I, Yokota T, Sano D, Kodaira T, Motegi A, Yasuda K, Takahashi S, Tanaka K, Onoe T, Okano S, Imamura Y, Ariizumi Y, Hayashi R. Human papillomavirus-related oropharyngeal carcinoma.Jpn J Clin Oncol. 2022 Jul 8;52(7):700-706. doi: 10.1093/jjco/hyac049.

Komatsu H, Furukawa T, Iritani K, Tatehara S, Takahashi M, Iwaki S, Kakei Y, Hasegawa T, Teshima M, Shinomiya H, Otsuki N, Hashikawa K, Kiyota N, Sasaki R, Akashi M, Nibu KI. Blowing time ratio and high-resolution manometry to evaluate swallowing function of patients with oral and oropharyngeal cancer.Auris Nasus Larynx. 2022 Jun;49(3):477-483. doi: 10.1016/j.anl.2021.10.013. Epub 2021 Nov 14.

Shinomiya H, Uehara N, Fujita T, Miyawaki D, Imamura Y, Teshima M, Kakigi A, Kiyota N, Sasaki R, Nibu KI. Phase I trial of concurrent chemoradiotherapy with docetaxel, cisplatin and 5-fluorouracil (TPF-CRT) for locally advanced squamous cell carcinoma of the external auditory canal.Eur Arch Otorhinolaryngol. 2022 Jun;279(6):2805-2810. doi: 10.1007/s00405-021-06974-4. Epub 2021 Jul 14.

Nakajima T, Nagano T, Miyata Y, Murakami S, Mitsuyuki S, Funakoshi Y, Yakushijin K, Horimoto H, Nishimura Y, Kobayashi K. Inhaled corticosteroids do not affect the antibody titer against the SARS-CoV-2 spike protein in BNT162b2 mRNA vaccinated patients.Allergy Asthma Clin Immunol. 2022 Aug 25;18(1):78. doi: 10.1186/s13223-022-00719-6..

Ainai S, Komaki R, Muramae N, Uno R, Mori K, Otsui K, Yakushijin K, Sakaguchi K. Biclonal Gammopathy as a Misleading Indicator to Diagnose POEMS Syndrome: An Autopsy Case Report and a Review of the Literature.Cureus. 2022 May 20;14(5):e25153. doi: 10.7759/cureus.25153. eCollection 2022 May.

Matsuyama Y, Hosoi H, Horitani R, Kawamoto S, Hashimoto T,Kimura M, Nakai H,Mushino T,Sonoki T. Management of warm autoimmune hemolytic anemia related to band 3-positive colon carcinoma. Ann Hematol. 2022 Jun;101(6):1343-1344. doi: 10.1007/s00277-021-04714-6. Epub 2021 Nov 5.

Koyama T, Ohji G, Nishida M,Nishimura S, Shirasugi I, Ohnuma K, Kusuki M, Iwata K. A case report of native vertebral osteomyelitis caused by Cutibacterium modestum.BMC Infect Dis. 2022 Apr 11;22(1):367. doi: 10.1186/s12879-022-07341-2.

Koyama T, Iwata K, Yamanaka K, Okada K, Miyakoshi C. Endovascular repair versus surgery for mycotic aneurysm a retrospective study with Bayesian inference.Surgery in Practice and Science Volume 10, September 2022, 100083

Goto H, Yakushijin K, Adachi Y, Matsumoto H, Yamamoto K, Matsumoto S, Yamashita T, Higashime A, Kawaguchi K, Kurata K, Matsuoka H, Minami H. A Pathogenic NRAS c.38G>A (p.G13D) Mutation in RARA Translocation-negative Acute Promyelocytic-like Leukemia with Concomitant Myelodysplastic Syndrome.Intern Med. 2023 May 1;62(9):1329-1334. doi: 10.2169/internalmedicine.0174-22. Epub 2022 Sep 21.

Tamaki M, Kameda K, Kimura SI, Harada N, Uchida N, Doki N, Tanaka M, Ikegame K, Sawa M, Katayama Y, Miyakoshi S, Ara T, Kanda J, Onizuka M, Fukuda T, Atsuta Y, Kanda Y, Yakushijin K, Nakasone H. Deletion of Y chromosome before allogeneic hematopoietic stem cell transplantation in male recipients with female donors.Blood Adv. 2022 Mar 22;6(6):1895-1903. doi: 10.1182/bloodadvances.2021006456.

Onishi C, Nishikori M, Yakushijin K, Kurahashi S, Nakazawa H, Takamatsu Y, Hashimoto Y, Tatetsu H, Yuichiro Nawa, Yoshida M, Kobayashi T, Oyake T, Yano S, Oride A, Suzuki R. Lymphoma during pregnancy in Japan: a multicenter retrospective cohort study.Int J Hematol. 2022 Mar;115(3):382-390. doi: 10.1007/s12185-021-03281-w. Epub 2022 Jan 3.

Yoshiaki Nagatani, Yohei Funakoshi, Hirotaka Suto, Yoshinori Imamura, Masanori Toyoda, Naomi Kiyota, Kimihiro Yamashita, Hironobu Minami.Immunosuppressive effects and mechanisms of three myeloid-derived suppressor cells subsets including monocytic-myeloid-derived suppressor cells, granulocytic-myeloid-derived suppressor cells, and immature-myeloid-derived suppressor cells. J Cancer Res Ther. Jul-Sep 2021;17(4):1093-1100.

Imamura Y, Tanaka K, Naomi K, Hayashi H, Ota I, Arai A, Iwae S, Minami S, Yane K, Yamazaki T, Nagatani Y, Toyoda M, Otsuski N, Nibu K, Minami H. Docetaxel and cisplatin in recurrent and/or metastatic non-squamous cell carcinoma of the head and neck: a multicenter phase II trial. Medical Oncol 2021; 38: 128. doi: 1007/s12032-021-01581-z. (Winner of the Young Investigator Award at 16th Japan Society of Medical Oncology)

Suzuki C, Kiyota N, Imamura Y, Goto H, Suto H, Chayahara N, Toyoda M, Ito Y, Miya A, Miyauchi A, Teshima M, Otsuki N, Nibu K, Minami H. Exploratory analysis to predict optimal tumor burden for starting lenvatinib in patients with radioiodine-refractory differentiated thyroid cancer. Frontier Oncol 2021; 11: 638123.

Koyama T, Funakoshi Y, Imamura Y, Nishimura S, Fujishima Y, Toyoda M, Kiyota N, Minami H. Device-related Mycobacterium mageritense infection in a patient treated with nivolumab for metastatic breast cancer: a case report. Intern Med 2021; doi: 10.2169/internalmedicine.6550-20. Online ahead of print.

Shinomiya H, Uehara N, Fujita T, Yoshida Y, Imamura Y, Teshima M, Kimura H, Miyawaki D, Kakigi A, Kiyota N, Otsuki N, Sasaki R, Kohmura E, Nibu K. New proposal to revise the classification for squamous cell carcinoma of the external auditory canal and middle ear. J Laryngol Otol 2021; 135: 297-303.

Nose T, Imamura Y, Ohata S, Kimbara S, Miyata Y, Hyogo Y, Fujishima Y, Funakoshi Y, Toyoda M, Kiyota N, Minami H. Incidence of venous thromboembolism in patients with solid cancers in Japan: retrospective study of 2735 patients. Int J Hematology 2021; 114; 319-324.

Hara H, Sakai Y, Kawamoto T, Fukase N, Kawakami Y, Takemori T, Fujiwara S, Kitayama K, Yahiro S, Miyamoto T, Imamura Y, Sasaki R, Kizawa Y, Minami H, Matsumoto T, Matsushita T, Kuroda R, Akisue T. Surgical outcomes of metastatic bone tumors in the extremities. J Bone Oncol 2021; 100352.

Kimbara S, Imamura Y, Kiyota N, Takakura H, Matsumoto S, Koyama T, Fujishima Y, Funakoshi Y, Toyoda M, Hirose T, Kanzawa M, Kawamoto T, Hara H, Minami H. Secondary CIC-rearranged sarcoma responsive to chemotherapy regimens for Ewing sarcoma: a case report. Mol Clin Oncol. 2021; 14: 68.

Okano S, Homma A, Kiyota N, Tahara M, Hanai N, Asakage T, Matsuura K, Ogawa T, Saito Y, Sano D, Kodaira T, Motegi A, Yasuda K, Takahashi S, Tanaka K, Onoe T, Yokota T, Imamura Y, Ariizumi Y, Akimoto T, Hayashi R. Induction chemotherapy in locally advanced squamous cell carcinoma of the head and neck. Jpn J Clin Oncol. 2021; 51: 173-179.

Yamamoto K, Yakushijin K, Mizutani Y, Okuni-Watanabe K, Goto H, Higashime A, Miyata Y, Kitao A, Matsumoto H, Saegusa J, Matsuoka H, Minami H. Expression of a novel type of KMT2A/EPS15 fusion transcript in FLT3 mutation-positive B-lymphoblastic leukemia with t(1;11)(p32;q23). Cancer Genetics 254-255: 92-97, 2021.

Yamamoto K, Kurata K, Higashime A, Sai S, Yakushijin K, Kawamoto S, Kajimoto K, Hayashi Y, Matsuoka H, Minami H. Non-inverted duplication of 11q, dup(11)(q11q24), in a diffuse large B cell lymphoma without MYC rearrangement: case report. SN Comprehensive Clinical Medicine 3: 1455-1462, 2021.

Hirotaka Suto, Yohei Funakoshi, Yoshiaki Nagatani, Yoshinori Imamura, Masanori Toyoda, Naomi Kiyota, Hisayuki Matsumoto, Shinwa Tanaka, Ryo Takai, Hiroshi Hasegawa, Kimihiro Yamashita, Takeru Matsuda, Yoshihiro Kakeji, Hironobu Minami. Microsatellite instability-high colorectal cancer patient-derived xenograft models for cancer immunity research. J Cancer Res Ther.Oct-Dec2021;17(6):1358-1369.doi: 10.4103/jcrt.JCRT_1092_20.

Sai S, Imamura Y, Kiyota N, Jimbo N, Toyoda M, Funakoshi Y, CHayahara N, Hyogo Y, Takenaka K, Suto H, Minami H. Relationship between the expression of PDGFR and the response of pazopanib in intimal sarcoma of the pulmonary artery：2 cases. Mol Clin Oncol. 2021 Jan;14(1):6. doi: 10.3892/mco.2020.2168.

Takai R, Funakoshi Y, Suto H, Nagatani Y, Imamura Y, Toyoda M, Yakushijin K, Kiyota N, Harada K,Yamashita K, Kakeji Y, Minami H. Serum Soluble Interleukin-2 Receptor as a Potential Biomarker for Immune-related Adverse Events. 2021 Feb;41(2):1021-1026. doi: 10.21873/anticanres.14857

Iida S, Sunami K, Minami H, Hatake K, Sekiguchi R, Natsume K, Ishikawa N, Vanasse KG, Taniwaki M. A phase I, multicenter, dose-escalation study of oral PIM447 in Japanese patients with relapsed and/or refractory multiple myeloma. Int J Hematol 113: 797-806, 2021.doi: 10.1007/s12185-021-03096-9

Minami H, Kiyota N, Ohmori T. Did the randomized phase III KEYNOTE-181 study of pembrolizumab for esophageal cancer yield negative or positive results? J Clin Oncol 2021 Jul 10;39(20):2317-2318. doi: 10.1200/JCO.20.03262.

Uhara H, Kiyohara Y, Uehara J, Fujisawa Y, Takenouchi T, Otsuka M, Uchi H, Fukushima S, Minami H, Hatsumichi M, Yamazaki N. Five-year survival with nivolumab in previously untreated Japanese patients with advanced or recurrent malignant melanoma. J Dematol 2021 May;48(5):592-599. doi: 10.1111/1346-8138.15804.

Tanaka Y, Tanaka H, Hatazawa K, Yamashita K, Sumimoto K, Shono A, Suzuki M, Yokota S, Suto M, Mukai J, Takada H, Matsumoto K, Minami H, Hirata K. Impact of hypertension on left ventricular function in patients after Anthracycline chemotherapy for malignant lymphoma. Int J Cardiol.2021 Jan 15;323:126-132. doi: 10.1016/j.ijcard.2020.08.019.

Minami , Kiyota N, Kimbara S, Ando Y, Shimokata T, Ohtsu A, Fuse N, Kuboki Y, Shimizu T, Yamamoto N, Nishio K, Kawakami Y, Nihira S, Sase K, Nonaka T, Takahashi H, Komori Y, Kiyohara K. Guidelines for clinical evaluation of anti-cancer drugs. Cancer Sci 2021 Jul;112(7):2563-2577. doi: 10.1111/cas.14967.

Mizuno M, Khaledian B, Maeda M, Hayashi T, Mizuno S, Munetsuna E, Watanabe T, Kono S, Okada S, Suzuki M, Takao S, Minami H, Asai N, Sugiyama F, Takahashi S, Shimono Y. Adipsin-dependent secretion of hepatocyte growth factor regulates the adipocyte-cancer stem cell interaction. Cancers.2021 Aug 23;13(16):4238. doi: 10.3390/cancers13164238.

Stein E, DeAngelo D, Chromik J, Chatterjee M, Bauer S, Lin C, Suarez C, de Vos F, Steegs N, Cassier P, Tai YMD, Kiladjian J, Yamamoto N, Mous R, Esteve J, Minami H, Ferretti S, Halilovic E, Guerreiro N, Meille C, Radhakrishnan R, Mariconti L, Fabre C, Carpio C. Results from a first-in-human phase I study of siremadlin (HDM201) in patients with advanced wild-type TP53 solid tumors and acute leukemia. Clin Cancer Res.2022 Mar 1;28(5):870-881. doi: 10.1158/1078-0432.CCR-21-1295.

Takahashi S, Karayama M, Takahashi M, Watanabe J, Minami H, Yamamoto N, Kinoshita I, Lin C-C, Im Y-H, Achiwa I, Kamiyama E, Okuda Y, Lee C, Bang Y-J. Pharmacokinetics, safety, and efficacy of trastuzumab deruxtecan with concomitant ritonavir or itraconazole in patients with HER2-expressing advanced solid tumors. Clin Cancer Res. 2021 Nov 1;27(21):5771-5780. doi: 10.1158/1078-0432.CCR-21-1560.

Ohji G, Funakoshi Y, Ebisawa K, Yakushijin K Arakawa y, Saegusa J, Kawamoto S, Imanishi T, Mori Y, Iwata K, Minami H. Cytokine Profiles of Rapid Recovery Patients with COVID-19. Kobe J Med Sci.2021 Oct 25;67(2):E55-E60.

Suto H, Funakoshi Y, Nagatani Y, Imamura Y, Toyoda M, Kiyota N, Matsumoto H, Tanaka S, Takai R, Hasegawa H, Yamashita K, Matsuda T, Kakeji Y, Minami H. Microsatellite instability-high colorectal cancer patient-derived xenograft models for cancer immunity research J Cancer Res Ther.Oct-Dec 2021;17(6):1358-1369. doi: 10.4103/jcrt.JCRT_1092_20.

Aoki T, Kagawa N, Sugiyama K, Wakabayashi T, Arakawa Y, Yamaguchi S, Tanaka S, Ishikawa E, Muragaki Y, Nagane M, Nakada M, Suehiro S, Hata N, Kuroda J, Narita Y, Sonoda Y, Iwadate Y, Natsumeda M, Nakazato Y, Minami H, Hirata Y, Hagihara S, Nishikawa R. Efficacy and safety of nivolumab in Japanese patients with first recurrence of glioblastoma: an open-label, non-comparative study. Int J Clin Oncol.2021 Dec;26(12):2205-2215. doi: 10.1007/s10147-021-02028-1.

Oe M, Miki K, Ueda Y, Mori Y, Okamoto A, Funakoshi Y, Minami H, Ohe K. Deep-red/near-infrared turn-on fluorescence probes for aldehyde dehydrogenase 1A1 in cancer stem cells. ACS Sens.2021 Sep 24;6(9):3320-3329. doi: 10.1021/acssensors.1c01136.

Funakoshi Y, Yakushijin K, Ohji G, Hojo W, Sakai H, Watanabe M, Kitao A, Miyata Y, Saito Y, Kawamoto S, Yamamoto K, Ito M, Koyama T, Imamura Y, Kiyota N, Matsuoka H, Mori Y, Minami H. Promising efficacy of a third dose of mRNA SARS-CoV-2 vaccination in patients treated with anti-CD20 antibody who failed 2-dose vaccination. Vaccines 10 (6): 965 (doi: 10.3390/vaccines10060965)

Funakoshi Y, Ohji G, Yakushijin K, Ebisawa K, Arakawa y, Saegusa J, Matsumoto H, Imanishi T, Fukuda E, Matsutani T, Mori Y, Iwata K, Minami H. Massive surge of mRNA expression of clonal B-cell receptor in patients with COVID-19. Heliyon 7; e07748

Ohji G, Funakoshi Y, Ebisawa K, Yakushijin K, Arakawa Y, Saegusa J, Kawamoto S, Imanishi T, Mori Y, Iwata K, Minami H. Serum Cytokine Profiles of Rapid Recovery Patients with COVID-19: Series of 6 Cases.Kobe J Med Sci. 2021 Oct 25;67(2):E55-E60.

Kurata K, Yamamoto K, Okazaki Y, Noguchi Y, Matsui K, Matsumoto H, Inui Y, Yakushijin K, Ito M, Nakamachi Y, Matsuoka H, Saegusa J, Minami H. Detection of a novel CBFB-MYH11 fusion transcript in acute myeloid leukemia M1 with inv(16)(p13q22). Cancer Genet 241: 72-76, 2020 (doi: 10.1016/j.cancergen.2019.07.005)

Sai S, Toyoda M, Tobimatsu K, Satake H, Yasui H, Kimbara S, Koyama T, Fujishima Y, Imamura Y, Funakoshi Y, Kiyota N, Toyama H, Kodama Y, Minami H. Phase 1 study of Gemcitabine/Nab-paclitaxel/S-1 in patients with unresectable pancreatic cancer (GeNeS1S trial). Cancer Chemother Pharmacol.2020 (doi: 10.1007/s00280-020-04174-1. Online ahead of print)

Sai S, Imamura Y, Kiyota N, Jimbo N, Toyoda M, Funakoshi Y, Chayahara N, Hyogo Y, Takenaka K, Suto H, Minami H. Relationship between PDGFR expression and the response to pazopanib in intimal sarcoma of the pulmonary artery: A case report. Molecular and clinical Oncology. 2020(6)

Kitao A. Kawamoto S, Kurata K, Hyakawa I, Yamasaki T, Matsuoka H, Sumi Y, Kakeji Y, Kmesaki T, Minami H. Band 3 ectopic expression in colorectal cancer induces an increase in erythrocyte memberane-bound IgG and may cause immune-related anemia. Int J Hematol 111（5）: 657-666, 2020 (doi: 10.1007/s12185-020-02831-y)

Kiyoi H, Morris JD, Oh I, Maeda Y, Minami H, Miyamoto T, Sakura T, Iida H, Tuglus CA, Chen Y, Dos Santos C, Kalabus J, Anderson A, Hata T, Nakashima Y, Kobayashi Y. Phase 1b/2 study of blinatumomab in Japanese adults with relapsed/refractory acute lymphoblastic leukemia. Cancer Sci 111(4): 1314-1323, 2020. ( doi: 10.1111/cas.14322.)

Yamamoto K, Yakushijin K, Ito M, Goto H, Higashime A, Kajimoto K, Hayashi Y, Matsuoka H, Minami H. MYC amplification on double minute chromosomes in plasma cell leukemia with double IGH/CCND1 fusion genes. Cancer Genet 242: 35-40, 2020 (doi: 10.1016/j.cancergen.2020.01.049)

Suzuki C, Kiyota N, Imamura Y, Rikitake J, Sai S, Koyama T, Hyogo Y, Nagatani Y, Funakoshi Y, Toyoda M, Otsuki N, Nibu K, Minami H. Effect of tumor burden and growth rate on treatment outcomes of nivolumab in head and neck cancer. Int J Clin Oncol 2020 25(7):1270-1277( doi: 10.1007/s10147-020-01669-y)

Ioroi T, Kiyota N, Imamura Y, Tanda M, Aoki S, Okuno M, Yamamoto K, Sasaki R, Nibu K, Minami H, Hirai M, Yano I. Ibuprofen gargle for chemo- or Chemoradiotherapy-induced Oral Mucositis: a feasibility study. J Pharm Health Care Sci 6: 12, 2020 (doi: 10.1186/s40780-020-00168-6)

Minami H, Ando Y, Tamura K, Tajima T, Isaacs R. Phase I Study of LFA102 in Patients With Advanced Breast Cancer or Castration-resistant Prostate Cancer. Anticancer Res 40(9): 5229-5235, 2020 (doi:10.21873/anticanres.14526)

Yen CJ, Kiyota N, Hanai N, Takahashi S, Yokota T, Iwae S, Shimizu Y, Hong RL, Goto M, Kang JH, Li WSK, Ferris RL, Gillison M, Endo T, Jayaprakash V, Tahara M. Two-year follow-up of a randomized phase III clinical trial of nivolumab vs. the investigator's choice of therapy in the Asian population for recurrent or metastatic squamous cell carcinoma of the head and neck (CheckMate 141). Head Neck. 2020;42(10):2852-2862.（doi: 10.1002/hed.26331.）

Takahashi S, Tahara M, Ito K, Tori M, Kiyota N, Yoshida K, Sakata Y, Yoshida A. Safety and Effectiveness of Lenvatinib in 594 Patients with Unresectable Thyroid Cancer in an All-Case Post-Marketing Observational Study in Japan. Adv Ther. 2020;37(9):3850-3862.（doi: 10.1007/s12325-020-01433-8.）

Yokota T, Homma A, Kiyota N, Tahara M, Hanai N, Asakage T, Matsuura K, Ogawa T, Saito Y, Sano D, Kodaira T, Motegi A, Yasuda K, Takahashi S, Tanaka K, Onoe T, Okano S, Imamura Y, Ariizumi Y, Hayashi R; Japan Clinical Oncology Group (JCOG) Head and Neck Cancer Study Group. Immunotherapy for squamous cell carcinoma of the head and neck. Jpn J Clin Oncol. 2020:28;50(10):1089-1096.（ doi: 10.1093/jjco/hyaa139.）

Minami H, Doi T, Toyoda M, Imamura Y, Kiyota N, Mitsuma A, Shimokata T, Naito Y, Matsubara N, Tajima T, Tokushige K, Ishihara K, Cameron S, Ando Y. Phase I study of the anti-PD-1 antibody spartalizumab (PDR001) in Japanese patients with advanced malignancies. Cancer Sci. 2020:8.（ doi: 10.1111/cas.14678.）

Terada M, Nakamura K, Martinelli F, Pe M, Mizusawa J, Eba J, Fukuda H, Kiyota N, Gatellier L, Majima Y, Velikova G, Bottomley A. Results from a 1-day workshop on the assessment of quality of life in cancer patients: a joint initiative of the Japan Clinical Oncology Group and the European Organisation for Research and Treatment of Cancer. Jpn J Clin Oncol. 2020:22;50(11):1333-1341.（doi: 10.1093/jjco/hyaa119）

Büttner M, Locati LD, Pinto M, Araújo C, Tomaszewska IM, Kiyota N, Vidhubala E, Brannan C, Hammerlid E, Husson O, Salem D, Ioannidis G, Gamper E, Arraras JI, Andry G, Inhestern J, Theurer J, Taylor K, Singer S. Quality of Life in Patients With Hypoparathyroidism After Treatment for Thyroid Cancer. J Clin Endocrinol Metab. 2020:1;105(12).(doi: 10.1210/clinem/dgaa597.）

Shiga K, Nibu KI, Fujimoto Y, Asakage T, Homma A, Mitani H, Ogawa T, Okami K, Murono S, Hirano S, Ueda T, Hanai N, Tsukahara K, Ota I, Yoshimoto S, Shinozaki T, Iwae S, Katagiri K, Saito D, Kiyota N, Tahara M, Takahashi F, Hayashi R. Multi-institutional Survey of Squamous Cell Carcinoma of the External Auditory Canal in Japan. Laryngoscope. 2020:30. （doi: 10.1002/lary.28936.）

Namikawa K, Kiyohara Y, Takenouchi T, Uhara H, Uchi H, Yoshikawa S, Takatsuka S, Koga H, Wada N, Minami H, Hatsumichi M, Namba Y, Yamazaki N. Final analysis of a phase II study of nivolumab in combination with ipilimumab for unresectable chemotherapy-naïve advanced melanoma. Journal of Dermatology 2020 Nov;47(11):1257-1266. doi: 10.1111/1346-8138.15514.

Kimbara S, Imamura Y, Yakushijin K, Higashime A, Koyama T, Fujishima Y, Funakoshi Y, Toyoda M, Kiyota N, Matsuoka H, Minami H. Regorafenib-induced exacerbation of chronic immune thrombocytopenic purpura in remission: a case report. Molecular and Clinical Oncology 2021 Feb;14(2):30. doi: 10.3892/mco.2020.2192.

Kurata K、Nishimura S, Higashime A, Kawaguchi K, Nagao S, Kozuki Y, Sai S, Yakushijin K, Yamamoto K, Ito M, Matsuoka H, Minami H. Disseminated cryptococcosis resembling miliary tuberculosis in a patient with acute myeloid leukemia. J Infection Cehmother 26(11):1216-1219, 2020 doi: 10.1016/j.jiac.2020.07.004

Hayashi H, Takiguchi y, Minami H, Akiyoshi K, Segawa Y, Ueda H, Iwamoto Y Kondoh C, Matsumoto K, Takahashi S, Yasui H, Sawa T, Onozawa Y, Chiba Y, Togashi Y, Fujita Y, Sakai K, Tomida S, Nishio K, Nakagawa K. Site-Specific and Targeted Therapy Based on Molecular Profiling by Next-Generation Sequencing for Cancer of Unknown Primary Site: A Nonrandomized Phase 2 Clinical Trial. JAMA Oncol 15: 6(12):1-9, 2020. (doi: 10.1001/jamaoncol.2020.4643.)

Tanaka Y, Tanaka H, Hatazawa K, Yamashita K, Sumimoto K, Shono A, Suzuki M, Yokota S, Suto M, Mukai J, Takada H, Matsumoto K, Minami H, Hirata K. Impact of hypertension on left ventricular function in patients after anthracycline chemotherapy for malignant lymphoma. Int J Cardiol 323: 126-132, 2021. doi: 10.1016/j.ijcard.2020.08.019

Kurata K, Matsumoto H, Jimbo N, Yakushijin K, Yamamoto K, Ito M, Nakamachi Y, Matsuoka H, Saegusa J, Seyama K, Ito T, Minami H. Lymphoplasmacytic lymphoma in a patient with Birt-Hogg-Dubé syndrome. Int J Hematol 2020 Dec;112(6):864-870. doi: 10.1007/s12185-020-02970-2.

Yamashita K, Tanaka H, Hatazawa K, Tanaka Y, Sumimoto K, Shono A, Suzuki M, Yokota S, Suto M, Mukai J, Takada H, Matsumoto K, Minami H, Hirata K. Association between clinical risk factors and left ventricular function in patients with breast cancer following chemotherapy. Int J Cardiovas Imaging 2021 Jan;37(1):197-205. doi: 10.1007/s10554-020-01976-5.

Morita-Ogawa T, Sugita H, Minami H, Yamaguchi T, Hanada K. Population pharmacokinetics and renal toxicity of cisplatin in cancer patients with renal dysfunction. Cancer Chemother Pharmacol 86: 559-566, 2020. doi: 10.1007/s00280-020-04147-4

Yanagi H, Watanabe T, Nishimura T, Hayashi T, Kono S, Takao S, Okada S, Suzuki M, Imaizumi K, Kawada K, Minami H, Gotoh N, Shimono Y. Upregulation of S100A10 in metastatized breast cancer stem cells. Cancer Sci 111:4359–4370 111:4359–4370. doi: 10.1111/cas.14659. Epub 2020 Oct 11.

Goto H, Shimono Y, Funakoshi Y, Imamura Y, Toyoda M, Kiyota N, Kono S, Takao S, Mukohara T, Minami H. Adipose-derived stem cells enhance human breast cancer growth and cancer stem cell-like properties throught adipsin. Oncogene 38(6): 767-779, 2019 (doi: 10.1038/s41388-018-0477-8)

Yamamoto K, Yakushijin K, Ichikawa H, Okamura A, Nagao S, Kakiuchi S, Kurata K, Kawamoto S, Matsui K, Nakamachi Y, Saegusa J, Matsuoka H, Minami H. Coexpression of ETV6/MDS1/EVI1 and ETV6/EVI1 fusion transcripts in acute myeloid leukemia with t(3;12)(q26.2;p13) and thrombocytosis. Leuk Lymphoma 60:1294-1298, 2019 (doi: 10.1080/10428194.2018.1529311)

Inui Y, Yakushijin K, Okamura A, Tanaka Y, Shinzato I, Nomura T, Ichikawa H, Mizutani Y, Kitao A, Kurata K, Kakiuchi S, Miyata Y, Sanada Y, Kitagawa K, Uryu K, Kawamoto S, Yamamoto K, Matsuoka H, Murayama T, Ito M, Minami H. Human herpesvirus 6 encephalitis in patients administered mycophenolate mofetil as prophylaxis for graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Transpl Infect Dis. 2019, 21(1): e13024,

Okuni M, Yakushijin K, Uehara K, Ichikawa H, Suto H, Hashimoto A, Tanaka Y, Shinzato I, Sakai R, Mizutani Y, Nagao S, Kurata K, Kakiuchi S, Miyata Y, Inui Y, Saito Y, Kawamoto S, Yamamoto K, Ito M, Matsuoka H, Minami H. Successful Bridging Chemotherapy with Gemcitabine, Carbopltin, and Dexamethasone before Unrelated Stem Cell Transplantation for Hepatosplenic T-cell Lymphoma. Intern Med 58(5): 707-712, 2019 (doi: 10.2169/internalmedicine.1266-18)

Chayahara N, Mukohara T, Tachihara M, Fujishima Y, Fukunaga A, Washio K, Yamamoto M, Nakata K, Kobayashi K, Takenaka K, Toyoda M, Kiyota N, Tobimatsu K, Doi H, Mizuta N, Marugami N, Kawaguchi A, Nishigori C, Nishimura Y, Minami H. Adapalene Gel 0.1% vs. Placebo as Prophylaxis for Anti-EGFR-Induced Acne-Like Rash: A Randomized Left-Right Comparative Evaluation (APPEARANCE). Oncologist 24(7):885-e413, 2019 (doi: 10.1634/theoncologist.2019-0156)

Suzuki C, Kiyota N, Imamura Y, Goto H, Suto H, Chayahara N, Toyoda M, Ito Y, Miya A, Miyauchi A, Otsuki N, Nibu K, Minami H. Exploratory analysis of prognostic factors for lenvatinib in radioiodine-refractory differentiated thyroid cancer. Head Neck , 2019 41(9):3023-3032 (doi: 10.1002/hed.25784, published on line, 2019)

Yamamoto K, Kawamoto S, Kitao A, Mizutani Y, Inui Y, Yakushijin K, Kajimoto K, Hayashi Y, Matsuoka H, Minami H. Double-hit pancreatic B-lymphoblastic lymphoma with a variant translocation t(2;18)(p11;q21). Int J Hematol 110(1): 107-114, 2019 (doi: 10.1007/s12185-019-02646-6)

Goto K, Fujiwara Y, Isobe T, Chayahara N, Kiyota N, Mukohara T,Tsubata Y, Hotta T, Tamura K, Yamamoto K, Minami H. Pharmacokinetic study of the oral fluorouracil antitumor agent S-1 in patients with impaired renal function. Cancer Sci 110(6): 1987-94, 2019 (doi: 10.1111/cas.14025)

Minami H, Fujiwara Y, Muro K, Sato M, Moriya A. Phase I study of BGT226, a pan-PI3K and mTOR inhibitor, in Japanese patients with advanced solid cancers. Cancer Chemother Pharmacol 84(2):337-343、2019. (doi.org/10.1007/s00280-019-03883-6)

Mizutani Y, Inase A, Maimaitili Y, Miyata Y, Kitao A, Matsumoto H, Kawaguchi K, Higashime A, Goto H, Kurata K, Yakushijin K, Minami H, Matsuoka H. An mTORC1/2 dual inhibitor, AZD2014, acts as a lysosomal function activator and enhances gemtuzumab ozogamicin-induced apoptosis in primary human leukemia cells. Int J Hematol 110(4): 490-499, 2019 (doi.org/10.1007/s12185-019-02701-2)

Yamamoto K, Yakushijin K, Okuni-Watanabe M, Hashimoto A, Matsuoka H, Minami H. Tetrasomy 8 and isochromosome 7q in CD5-positive hepatosplenic T-cell lymphoma with leukemic presentation. Int J Hematol 110(5): 521-523, 2019 (doi: 10.1007/s12185-019-02708-9)

Nagatani Y, Imamura Y, Nakamura T, Yamashita K, Okuno M, Yasui H, Hiraoka J, Niigata R, Kono K, Hyogo Y, Suto H, Takenaka K, Funakoshi Y, Toyoda M, Kiyota N, Minami H. Pharmacokinetics of Oxaliplatin in a Hemodialysis Patient with Metastatic Colon Cancer. International journal of Oncology Research. 2019; 2: 017

Okuni M, Yakushijin K, Uehara K, Icikawa H, Suto H, Hashimoto A, Tanaka Y, Shinzato I, Sakai R, Mizutani Y, Nagao S, Kurata K, Kakiuchi S, Miyata Y, Inui Y, Saito Y, Kawamoto S, Yamamoto K, Ito M, Matsuoka H, Minami H. Successful Bridging Chemotherapy with Gemcitabine, Carboplatin, and Dexamethasone before Unrelated Stem Cell Transplantation for Hepatosplenic T-cell Lymphoma. Internal Med 58(5); 707-12, 2019

Imamura Y, Kiyota N, Ogawa G, Akimoto T, Fujii M, Hanai N, Iwae S, Monden N, Matsuura K, Onozawa Y, Hayashi R, and Tahara M. Nutritional support dependence after curative chemoradiotherapy in head and neck cancer: supplementary analysis of a phase II trial (JCOG0706S1). Jpn J Clin Oncol. 2019; 49(11): 1009-1015.

Matsuzuka T, Kiyota N, Mizusawa J, Akimoto T, Fujii M, Hasegawa Y, Iwae S, Monden N, Matsuura K, Onozawa Y, Hayashi R, Tahara M; Japan Clinical Oncology Group(JCOG) Head and Neck Cancer Study Group. Clinical impact of cachexia in unresectable locally advanced head and neck cancer: supplementary analysis of a phase II trial (JCOG0706-S2). Jpn J Clin Oncol. 2019;49(1):37-41.（doi: 10.1093/jjco/hyy145.）

Teshima M, Otsuki N, Shinomiya H, Morita N, Furukawa T, Morimoto K, Nakamura T, Hashikawa K, Kiyota N, Sasaki R, Nibu KI. Impact of retropharyngeal lymph node dissection in the surgical treatment of hypopharyngeal cancer. Head Neck. 2019;41(6):1738-1744.（doi: 10.1002/hed.25608.）

Singer S, Amdal CD, Hammerlid E, Tomaszewska IM, Castro Silva J, Mehanna H, Santos M, Inhestern J, Brannan C, Yarom N, Fullerton A, Pinto M, Arraras JI, Kiyota N, Bonomo P, Sherman AC, Baumann I, Galalae R, Fernandez Gonzalez L, Nicolatou-Galitis O, Abdel-Hafeez Z, Raber-Durlacher J, Schmalz C, Zotti P, Boehm A, Hofmeister D, Krejovic Trivic S, Loo S, Chie WC, Bjordal K, Brokstad Herlofson B, Grégoire V, Licitra L; EORTC Quality of Life and the EORTC Head and Neck Cancer Groups. International validation of the revised European Organisation for Research and Treatment of Cancer Head and Neck Cancer Module, the EORTC QLQ-HN43: Phase IV. Head Neck. 2019;41(6):1725-1737.（doi: 10.1002/hed.25609. ）

Takahashi S, Kiyota N, Yamazaki T, Chayahara N, Nakano K, Inagaki L, Toda K, Enokida T, Minami H, Imamura Y, Fukuda N, Sasaki T, Suzuki T, Ikezawa H, Dutcus CE, Tahara M. A Phase II study of the safety and efficacy of lenvatinib in patients with advanced thyroid cancer. Future Oncol. 2019;15(7):717-726（doi: 10.2217/fon-2018-0557.）

Burtness B, Haddad R, Dinis J, Trigo J, Yokota T, de Souza Viana L, Romanov I, Vermorken J, Bourhis J, Tahara M, Martins Segalla JG, Psyrri A, Vasilevskaya I, Nangia CS, Chaves-Conde M, Kiyota N, Homma A, Holeckova P, Del Campo JM, Asarawala N, Nicolau UR, Rauch D, Even C, Wang B, Gibson N, Ehrnrooth E, Harrington K, Cohen EEW; LUX-Head & Neck 2 investigators. Afatinib vs Placebo as Adjuvant Therapy After Chemoradiotherapy in Squamous Cell Carcinoma of the Head and Neck: A Randomized Clinical Trial. JAMA Oncol. 2019: 13;5(8):1170-1180（doi: 10.1001/jamaoncol.2019.1146.）

Ito Y, Ishikawa H, Kihara M, Hirokawa M, Kiyota N, Kasahara T, Miyauchi A. Control of Lung Metastases and Colon Polyposis with Lenvatinib Therapy in a Patient with Cribriform-Morular Variant of Papillary Thyroid Carcinoma and an APC Gene Mutation: A Case Study. Thyroid. 2019;29(10):1511-1517.（doi: 10.1089）

Saba NF, Blumenschein G Jr, Guigay J, Licitra L, Fayette J, Harrington KJ, Kiyota N, Gillison ML, Ferris RL, Jayaprakash V, Li L, Brossart P. Nivolumab versus investigator's choice in patients with recurrent or metastatic squamous cell carcinoma of the head and neck: Efficacy and safety in CheckMate 141 by age. Oral Oncol. 2019;96:7-14.（doi: 10.1016/j.oraloncology.2019.06.017.）

Szturz P, Wouters K, Kiyota N, Tahara M, Prabhash K, Noronha V, Adelstein D, Van Gestel D, Vermorken JB. Low-Dose vs. High-Dose Cisplatin: Lessons Learned From 59 Chemoradiotherapy Trials in Head and Neck Cancer. Front Oncol. 2019:21;9:86. （doi: 10.3389/fonc.2019.00086. Review）

Head and Neck Cancer Study Group (HNCSG), Monden N, Asakage T, Kiyota N, Homma A, Matsuura K, Hanai N, Kodaira T, Zenda S, Fujii H, Tahara M, Yokota T, Akimoto T, Iwae S, Onitsuka T, Ogawa T, Okano S, Takahashi S, Shimizu Y, Yonezawa K, Hayashi R. A review of head and neck cancer staging system in the TNM classification of malignant tumors (eighth edition). Jpn J Clin Oncol. 2019;49(7):589-595. （doi: 10.1093/jjco/hyz052.Review）

Muro K, Lordick F, Tsushima T, Pentheroudakis G, Baba E, Lu Z, Cho BC, Nor IM, Ng M, Chen LT, Kato K, Li J, Ryu MH, Zamaniah WIW, Yong WP, Yeh KH, Nakajima TE, Shitara K, Kawakami H, Narita Y, Yoshino T, Van Cutsem E, Martinelli E, Smyth EC, Arnold D, Minami H, Tabernero J, Douillard JY. Pan-Asia adapted ESMO clinical guidelines for management of patients with metastatic oesophageal cancer; a JSMO-ESMO initiative endorsed by CSCO, KSMO, MOS, SSO and TOS. Ann Oncol 30: 34-43, 2019 (doi:10.1093/annonc/mdy498)

Gerds AT, Tauchi T, Ritchie E, Deininger M, Jamieson C, Mesa R, Heaney M, Komatsu N, Minami H, Su Y, Naveed Shaik M, Zhang X, DiRienzo C, Zeremski M, Chan G, Talpaz M. Phase 1/2 trial of glasdegib in patients with primary or secondary myelofibrosis previously treated with ruxolitinib. Leukemia Res 79: 38-44, 2019 (doi: 10.1016/j.leukres.2019.02.012)

Yamada H, Kurinoto T, Mori S, Sakamoto M, Ueda K, Yamada-Nakanishi Y, Uozumi Y, Shose H, Taniguchi M, Toyoda M, Minami H, Nakamura M. A case of multi-system Langerhans cell histiocytosis with local invasion of the orbital apex. Case Rep Oththalmol 10(3):319-326, 2019 (doi: 10.1159/000502946)

Yamazaki N, Kiyohara Y, Uhara H, Uehara J, Fujisawa Y, Takenouchi T, Otsuka M, Uchi H, Ihn H, Hatsumichi M, Minami H. Long-term follow up of nivolumab in previously untreated Japanese patients with advanced or recurrent malignant melanoma. Cancer Sci 110(6): 1995-2003, 2019. (doi: 10.1111/cas.14015).

Toyoda M, Watanabe K, Amagasaki T, Natsume K, Takeuchi H, Quadt C, Shirao K, Minami H. A Phase I study of single-agent BEZ235 special delivery system sachet in Japanese patients with advanced solid tumors. Cancer Chemother Pharmacol 83: 289-299, 2019 (doi.org/10.1007/s00280-018-3725-2)

Hayashi H, Kurata T, Takiguchi Y, Arai M, Takeda K, Akiyoshi K, Matsumoto K, Onoue T, Mukai H, Matsubara N, Minami H, Toyota M, Onozawa Y, Ono A, Fujita Y, Sakai K, Koh Y, Takeuchi A, Nishio K, Nakagawa K. Randomized phase II trial comparing site-specific treatment based on gene expression profiling with carboplatin-paclitaxel for patients with cancer of unknown primary site. J Clin Oncol 37: 570-579, 2019 (doi: 10.1200/JCO.18.00771)

Muro K, Van Cutsem E, Narita Y, Pentheroudakis G, Baba E, Li J, Ryu MH, Zamaniah WIW, Yong WP, Yeh KH, Kato K, Lu Z, Cho BC, Nor IM, Ng M, Chen LT, Nakajima TE, Shitara K, Kawakami H, Tsushima T, Yoshino T, Lordick F, Martinelli E, Smyth EC, Arnold D, Minami H, Tabernero J, Douillard JY. Pan-Asia adapted ESMO clinical guidelines for management of patients with metastatic gastric cancer; a JSMO-ESMO initiative endorsed by CSCO, KSMO, MOS, SSO and TOS. Ann Oncol 30: 19-33, 2019 (doi: 10.1093/annonc/mdy502)

Tamura K, Hasegawa K, Katsumata N, Matsumoto K, Mukai H, Takahashi S, Nomura H, Minami H. Efficacy and safety of nivolumab in Japanese patients with uterine cervical cancer, uterine corpus cancer, or soft tissue sarcoma: multicenter, opemn-label phase 2 trial. Cancer Sci 110: 2894-2904, 2019 (doi. 10.1111/cas.14148

Mukohyama J, Isobe T, Hu Q, Hayashi T, Watanabe T, Maeda M, Yanagi H, Qian X, Yamashita K, Minami H, Mimori K, Sahoo D, Kakeji Y, Suzuki A, Dalerba P, Shimono Y. miR-221 targets QKI and enhances the tumorigenic capacity of human colorectal cancer stem cell populations. Cancer Res 79: 5151-58, 2019 (doi: 10.1158/0008-5472.CAN-18-3544)

Hughes TP, Mauro MJ, Cortes JE, Minami H, Rea D, DeAngelo DJ, Breccia M, Goh Y-T, Talpaz, M, Hochhaus A, le Coutre P, Ottmann O, Heinrich, MC, Steegmann JL, Deininger MWN, Janssen JJWM, Mahon F-X, Minami Y, Yeung D, Ross DM, Tallman MS, Park JH, Druker BJ, Hynds D, Duan R, Meille C, Hourcade-Potelleret F, Vanasse KG, Lang F, Kim D-W. Asciminib in tyrosine kinase inhibitor–resistant and –intolerant chronic myeloid leukemia. New Engl J Med 381; 2315-2326, 2019 (doi: 10.1056/NEJMoa1902328)