Research Themes
主な研究テーマ
- がん患者(がんロコモ含む)や骨転移患者に対するリハビリテーション治療の研究
- 希少疾患(筋ジストロフィー・脊髄性筋萎縮症・色素性乾皮症等)の治療に伴う身体機能評価の研究
- 各疾患における医療機器プログラム(SaMD)を用いた歩行分析
- VR(Virtual Reality)を用いたリハビリテーション治療開発
- リハビリテーション機器開発・適応拡大に関する研究(カーボン製装具 / 炭酸ガス経皮吸収 / 拡散型圧力波等)
- ICU-acquired weakness(ICU-AW)の予後予測因子や予防に関する研究
Awards
受賞歴
2025年10月 第9回日本リハビリテーション医学会秋季学術集会 YIA最優秀賞 鹿島遼河
2025年3月 Progress in Rehabilitation Medicine, Best Reviewer Award 吉川遼
2024年11月 第8回日本リハビリテーション医学会秋季学術集会 YIA最優秀賞 大西宏和
2024年3月 日本リハビリテーション医学会 国際誌論文賞優秀論文賞 松本健
2024年3月 Progress in Rehabilitation Medicine, Best Reviewer Award 原田理沙
2023年11月 第7回日本リハビリテーション医学会秋季学術集会 YIA優秀賞 吉川遼
2023年6月 第60回日本リハビリテーション医学会学術集会 優秀賞 酒井良忠
2022年11月 第6回日本リハビリテーション医学会秋季学術集会 YIA優秀賞 津田悠三
2020年11月 第4回日本リハビリテーション医学会秋季学術集会 YIA優秀賞 吉川遼
2016年10月 第11回リハビリテーション科専門医会学術集会 優秀演題賞 原田理沙
Publications
主な論文業績
2026
Phase angle measured by bioelectrical impedance analysis as a predictor of exercise capacity in patients undergoing late-recovery phase cardiac rehabilitation.
Original Eur J Prev Cardiol. 2026 Apr 22;33(6):910-916. PubMed
Automated Gait Assessment for Rehabilitation Training Using Pose Tracking and Dynamic Time Warping.
Original Diagnostics (Basel). 2026 Apr 14;16(8):1164. PubMed
Metabolic and muscular effects of switching from somatropin to somapacitan in adults with growth hormone deficiency.
Original J Clin Endocrinol Metab. 2026 Apr 7. PubMed
Association of knee extensor strength symmetry and psychological factors with single-leg hop performance differs according to recovery of knee extensor strength after anterior cruciate ligament reconstruction with hamstring autograft.
Original J Orthop Sci. 2026 Jan 21. PubMed
Knee extensor strength normalised to body weight is associated with patient-reported outcomes at 12 months after open-wedge high tibial osteotomy.
Original J Exp Orthop. 2026 Jan;13(1):e70625. PubMed
2025
Synergistic effects of underweight and dementia on in-hospital mortality during acute myocardial infarction.
Original Eur J Cardiovasc Nurs. 2025 Dec 29;24(8):1354-1362. PubMed
Combined Extracorporeal Shock Wave Therapy and Botulinum Toxin Injection for Spasticity in the Acute Phase of Spinal Cord Injury: A Case Report.
Case Report Prog Rehabil Med. 2025 Dec 10;10:20250038. PubMed
Impact of preoperative beta-hydroxy-beta-methylbutyrate, arginine, and glutamine supplementation on inflammation in patients with cardiac surgery.
Original J Cardiol. 2025 Dec;86(6):561-567. PubMed
Usefulness of 3D joint space width on weight-bearing CT in comparison with 2D joint space width on radiographs for predicting 24-month worsening of knee osteoarthritis pain and function in the MOST study.
Original Osteoarthritis Cartilage. 2025 Nov 7;34(2):290-296. PubMed
Institutional disparities in the treatment of bone metastases by orthopaedic surgeons at training facilities designated by the Japanese orthopaedic association.
Original J Orthop Sci. 2025 Nov;30(6):1158-1164. PubMed
Transcutaneous carbon dioxide improves joint inflammation and articular cartilage degeneration in rat osteoarthritis models.
Original Bone Joint Res. 2025 Oct 22;14(10):888-900. PubMed
Effect of intermittent extracellular low-pH environment on human umbilical vein endothelial cell activity.
Original PLoS One. 2025 Sep 16;20(9):e0332673. PubMed
Body Mass Index Affects Hospital-Associated Disability and Economic Burden in Elective Cardiovascular Surgery.
Original Circ J. 2025 Aug 25;89(9):1538-1546. PubMed
Efficacy of radial extracorporeal shock wave therapy in hereditary spastic paraplegia: A case report.
Case Report Medicine (Baltimore). 2025 Aug 8;104(32):e41921. PubMed
Association between preoperative grip strength and postoperative upper extremity impairments in patients with breast cancer.
Original Breast Cancer. 2025 Jul;32(4):750-756. PubMed
Body mass index is associated with disability at discharge as indicated by the modified Rankin Scale in patients with ischemic stroke.
Original Top Stroke Rehabil. 2025 Jul;32(5):502-511. PubMed
Effectiveness of rehabilitation treatment for bone metastasis patients without surgical intervention: A propensity score matching analysis.
Original J Bone Oncol. 2025 Jul 19;53:100703. PubMed
Usefulness of the Phase Angle in Evaluating Locomotive Syndrome in Cancer Patients.
Original J Clin Med. 2025 Jun 5;14(11):3980. PubMed
U-shaped relationship between body mass index and intracerebral hemorrhage-related functional decline.
Original Neurol Res. 2025 Apr;47(4):296-305. PubMed
Efficacy of asfotase alfa in a patient with adult-onset hypophosphatasia without obvious bone lesions.
Original Endocr J. 2025 Apr 1;72(4):437-445. PubMed
Effects of preoperative beta-hydroxy-beta-methylbutyrate, arginine, and glutamine supplementation on cardiac surgery.
Original Clin Nutr. 2025 Feb;45:91-100. PubMed
Gait Parameters and Postoperative Pain Following Total Ankle Arthroplasty Using Wearable Motion Sensors: A Cross-Sectional Study.
Original Cureus. 2025 Feb 2;17(2):e78392. PubMed
多発骨転移のある治療中の乳癌患者に対し密接な病病連携を行って回復期病棟での入院・訓練を行い良好なADLを得た一例.
Case Report Journal of Rehabilitation Practice. (25):30-34, 2025.
2024
Modified Frailty Index as a novel predictor for the incidence and severity of postoperative complications after spinal metastases surgery.
Original Bone Joint J. 2024 Dec 1;106-B(12):1469-1476. PubMed
Quadriceps strength can improve twelve months after opening wedge high tibial osteotomy and opening wedge distal tibial tubercle osteotomy.
Original Knee. 2024 Dec;51:258-267. PubMed
Transcutaneous CO2 application combined with low-intensity pulsed ultrasound accelerates bone fracture healing in rats.
Original BMC Musculoskelet Disord. 2024 Oct 29;25(1):863. PubMed
Multidisciplinary Treatment for Breast Cancer-related Multiple Bone Metastases during Pregnancy Using Bone Metastasis Cancer Boards: A Case Report.
Case Report Prog Rehabil Med. 2024 Oct 2;9:20240032. PubMed
Preventive effects of transcutaneous CO2 application on disuse osteoporosis and muscle atrophy in a rat hindlimb suspension model.
Original Bone. 2024 Sep 18;189:117262. PubMed
Three-dimensional printed calcium phosphate scaffolds emulate bone microstructure to promote bone regrowth and repair.
Original J Mater Sci Mater Med. 2024 Sep 3;35(1):53. PubMed
Evaluating the Effectiveness of the Driving Resumption Assessment in Brain Disorders: Insights From a Retrospective Observational Study.
Original Cureus. 2024 Jul 24;16(7):e65304. PubMed
Evaluation of Changes in Activities of Daily Living and Quality of Life of Patients with Bone Metastasis Who Underwent Conservative Therapy through Bone Metastasis Cancer Boards.
Original Medicina (Kaunas). 2024 May 29;60(6):906. PubMed
Impact of maximum phonation time on postoperative dysphagia and prognosis after cardiac surgery.
Original JTCVS Open. 2024 Apr;18:123-137. PubMed
Association Between Psychological Readiness to Return to Sports at 3 Months Postoperatively and Risk of Second ACL Injury.
Original Orthop J Sports Med. 2024 Apr;12(4):23259671241239325. PubMed
Factors Influencing Life Space Mobility in Cancer Survivors Following Hematopoietic Stem Cell Transplantation.
Original Hematol Oncol Stem Cell Ther. 2024 Mar 22;17(2):146-153. PubMed
Effects of high antibiotic concentrations applied to continuous local antibiotic perfusion on human bone tissue-derived cells.
Original Bone Joint Res. 2024 Mar 1;13(3):91-100. PubMed
Clinical Characteristics, Surgical Outcomes, and Risk Factors for Emergency Surgery in Patients With Spinal Metastases.
Original Neurospine. 2024 Mar;21(1):314-327. PubMed
Activity of Daily Living and Walking Ability of Patients with Severe COVID-19 at Discharge from an Acute Care Hospital.
Original Prog Rehabil Med. 2024 Jan 23;9:20240003. PubMed
骨粗鬆症性大腿骨骨折術後の回復期リハビリテーション経過中に足関節周囲骨挫傷を併発した3症例の経験.
Case Report Journal of Rehabilitation Practice. (24):49-52, 2024.
2023
Effect of Bone Metastasis Cancer Board on Spinal Surgery Outcomes: A Retrospective Study.
Original Medicina (Kaunas). 2023 Nov 28;59(12):2087. PubMed
Combining age, sex, body mass index, sport level, and preoperative quadriceps strength improves the predictive ability of quadriceps strength recovery after ACL reconstruction.
Original Knee Surg Sports Traumatol Arthrosc. 2023 Oct;31(10):4390-4398. PubMed
Postoperative dysphagia as a predictor of functional decline and prognosis after undergoing cardiovascular surgery.
Original Eur J Cardiovasc Nurs. 2023 Sep 5;22(6):602-609. PubMed
Clinical Characteristics and Surgical Outcomes of Metastatic Spine Tumors in the Very Elderly.
Original J Clin Med. 2023 Jul 18;12(14):4747. PubMed
Investigation of Changes in Skeletal Muscle Mass and Muscle Quality and Factors Affecting Changes in Deceased Donor Liver Transplantation.
Original Transplant Proc. 2023 Jul 9;55(7):1649-1655. PubMed
Demographic, Physical, and Psychological Determinants of Patient Experience with Subcutaneous Self-Injection in Patients with Rheumatoid Arthritis.
Original Patient Prefer Adherence. 2023 Jul 3;17:1551-1559. PubMed
Effect of low-intensity pulsed ultrasound on osteogenic differentiation of human induced membrane-derived cells in Masquelet technique.
Original Injury. 2023 Jun;54(6). PubMed
Predictors of Activities of Daily Living in Intensive Care Unit Survivors: A Propensity Score Matching Analysis.
Original Prog Rehabil Med. 2023 Mar 29;8:20230010. PubMed
Reliability and Validity of Quadriceps Muscle Thickness Measurements in Ultrasonography: A Comparison with Muscle Mass and Strength.
Original Prog Rehabil Med. 2023 Mar 11;8:20230008. PubMed
Involvement of orthopaedic surgeons for cancer patients in orthopaedic training facilities certified by the Japanese Orthopaedic Association.
Original J Orthop Sci. 2023 Mar;28(2):446-452. PubMed
The Identification of Risk Factors for Symptomatic Spinal Metastasis Onset.
Original Cancers (Basel). 2023 Feb 16;15(4):1251. PubMed
Fuzzy Logic Evaluation of Knee Flexion Angle During Gait.
Original 2023 International Conference on Machine Learning and Cybernetics. 2023. IEEE Xplore
オーダーメイドの指装具使用により手指ボタンホール変形の改善を認めた関節リウマチの一症例.
Case Report リハビリテーション科診療. (23):59-63, 2023.
骨転移キャンサーボードの実施により早期の日常生活動作の獲得が可能であった両側大腿骨髄内釘固定術後の一症例.
Case Report 理学療法学. 50(6):246-250, 2023.
2022
Hospital-associated disability and hospitalization costs for acute heart failure stratified by body mass index- insight from the JROAD/JROAD-DPC database.
Original Int J Cardiol. 2022 Nov 15;367:38-44. PubMed
Impact of body mass index on in-hospital mortality for six acute cardiovascular diseases in Japan.
Original Sci Rep. 2022 Nov 7;12(1):18934. PubMed
Human Non-Hypertrophic Nonunion Tissue Contains Osteoblast Lineage Cells and E-BMP-2 Activates Osteogenic and Chondrogenic Differentiation.
Original Curr Issues Mol Biol. 2022 Nov 9;44(11):5562-5578. PubMed
Survival Rate after Palliative Surgery Alone for Symptomatic Spinal Metastases: A Prospective Cohort Study.
Original J Clin Med. 2022 Oct 22;11(21):6227. PubMed
母指指節間関節橈側亜脱臼に対して装具療法を行い,長期にわたり母指機能を維持できた関節リウマチの1例.
Case Report The Japanese Journal of Rehabilitation Medicine. 59(10):1056-1060, 2022. J-STAGE
Assessment of the upper limb muscles in patients with Fukuyama muscular dystrophy: Noninvasive assessment using visual ultrasound muscle analysis and shear wave elastography.
Original Neuromuscul Disord. 2022 Sep;32(9):754-762. PubMed
Association Between Meeting Return-to-Sport Criteria and Psychological Readiness to Return to Sport After Anterior Cruciate Ligament Reconstruction.
Original Orthop J Sports Med. 2022 May 10;10(5):23259671221093985. PubMed
Clinical Outcome of Patients with Bone Metastases in a Convalescent Rehabilitation Ward: A Case Series of Six Patients.
Case Report Prog Rehabil Med. 2022 Apr 29;7:20220022. PubMed
Singing Experience Influences RSST Scores.
Original Healthcare (Basel). 2022 Feb 16;10(2):377. PubMed
TresLock for Unstable Proximal Femoral Fractures: Morphological Compatibility and Clinical Results: A Case Series.
Case Report J Orthop Case Rep. 2022 Feb;12(2):49-52. PubMed
Low-Intensity Pulsed Ultrasound Promotes Osteogenic Differentiation of Reamer-Irrigator-Aspirator Graft-Derived Cells in Vitro.
Original Ultrasound Med Biol. 2022 Feb;48(2):313-322. PubMed
Impact of Frailty on Postoperative Dysphagia in Patients Undergoing Elective Cardiovascular Surgery.
Original JACC Asia. 2022 Feb 1;2(1):104-113. PubMed
筋筋膜性疼痛症候群に対して運動療法と経皮的電気刺激治療の併用が有効であった進行性卵巣癌の一症例.
Case Report 理学療法学. 49(2):155-161, 2022.
2021
The effect of home-based preoperative pulmonary rehabilitation before lung resection: A retrospective cohort study.
Original Lung Cancer. 2021 Dec;162:135-139. PubMed
Satisfaction with playing pre-injury sports 1 year after anterior cruciate ligament reconstruction using a hamstring autograft.
Original Knee. 2021 Dec;33:282-289. PubMed
Impact of Sarcopenia as a Prognostic Factor on Reductive Hepatectomy for Advanced Hepatocellular Carcinoma.
Original Anticancer Res. 2021 Nov;41(11):5775-5783. PubMed
Hydration Status of Junior Tennis Players and the Difference after a Lecture on Its Practice.
Original Kobe J Med Sci. 2021 Nov 2;67(3):E79-E83. PubMed
Impact of Preoperative Social Frailty on Overall Survival and Cancer-Specific Survival among Older Patients with Gastrointestinal Cancer.
Original J Am Med Dir Assoc. 2021 Sep;22(9):1825-1830.e1. PubMed
Preoperative frailty affects postoperative complications, exercise capacity, and home discharge rates after surgical and transcatheter aortic valve replacement.
Original Heart Vessels. 2021 Aug;36(8):1234-1245. PubMed
Intensive Care Unit Admission for Moderate-to-Severe COVID-19 Patients With Known Cardiovascular Diseases or Their Risk Factors.
Original Circ Rep. 2021 Jul 9;3(7):375-380. PubMed
Surgical outcomes and risk factors for poor outcomes in patients with cervical spine metastasis: a prospective study.
Original J Orthop Surg Res. 2021 Jul 3;16(1):423. PubMed
Effects of acute-phase multidisciplinary rehabilitation on unplanned readmissions after cardiac surgery.
Original J Thorac Cardiovasc Surg. 2021 May;161(5):1853-1860.e2. PubMed
Surgical outcomes of metastatic bone tumors in the extremities.
Original J Bone Oncol. 2021 Apr;27:100352. PubMed
Histological analysis of induced membranes in patients whose bone defects were treated with the Masquelet technique to identify factors affecting the vascularity of induced membranes.
Original J Orthop Surg Res. 2021 Apr 13;16(1):248. PubMed
Impact of Oral Health Status on Postoperative Complications and Functional Recovery After Cardiovascular Surgery.
Original CJC Open. 2021 Mar;3(3):276-284. PubMed
In vivo evaluation of percutaneous carbon dioxide treatment for improving intratumoral hypoxia using (18)F-fluoromisonidazole PET-CT.
Original Oncol Lett. 2021 Mar;21(3):207. PubMed
Relationship between oral health and physical frailty in patients with cardiovascular disease.
Original J Cardiol. 2021 Feb;77(2):131-138. PubMed
2020
Transcutaneous CO2 application accelerates fracture repair in streptozotocin-induced type I diabetic rats.
Original BMJ Open Diabetes Res Care. 2020 Dec;8(2):e001129. PubMed
Prospective cohort study of surgical outcome for spinal metastases in patients aged 70 years or older.
Original Bone Joint J. 2020 Dec;102-B(12):1709-1716. PubMed
Effects of the duration of transcutaneous CO2 application on the facilitatory effect in rat fracture repair.
Original J Orthop Sci. 2020 Sep;25(5):886-891. PubMed
Tibial shape and size predicts the risk of tibial plateau fracture after cementless unicompartmental knee arthroplasty in Japanese patients.
Original Bone Joint J. 2020 Jul;102-B(7):861-867. PubMed
Chronotherapy targeting cytokine secretion attenuates collagen-induced arthritis in mice.
Original Int Immunopharmacol. 2020 Jul;84:106549. PubMed
Physical activity among patients with breast cancer receiving aromatase inhibitors is associated with bone health: a cross-sectional observational study.
Original Breast Cancer Res Treat. 2020 Jul;182(1):187-193. PubMed
Longitudinal Quadriceps Strength Recovery After Anterior Cruciate Ligament Reconstruction With Hamstring Autograft: Patients Stratified by Preoperative Quadriceps Strength Deficit.
Original J Sport Rehabil. 2020 Jul 1;29(5):602-607. PubMed
Social frailty as a risk factor for new-onset depressive symptoms at one year post-surgery in older patients with gastrointestinal cancer.
Original J Geriatr Oncol. 2020 Jun;11(5):904-907. PubMed
The Medial Eminence Line for Predicting Tibial Fracture Risk after Unicompartmental Knee Arthroplasty.
Original Clin Orthop Surg. 2020 Apr 27;12(2):166-170. PubMed
Altered microRNA profile during fracture healing in rats with diabetes.
Original J Orthop Surg Res. 2020 Apr 7;15(1):135. PubMed
Expressions of circadian clock genes represent disease activities of RA patients treated with biological DMARDs.
Original Mod Rheumatol. 2020 Mar;30(2):293-300. PubMed
Transcutaneous carbon dioxide application inhibits muscle atrophy after fracture in rats.
Original J Orthop Sci. 2020 Mar;25(2):338-343. PubMed
Association between preoperative sleep disturbance and low muscle mass in patients with gastrointestinal cancer.
Original J Phys Ther Sci. 2020 Jan;32(1):59-64. PubMed
Staged Bilateral Total Knee Arthroplasty in a Patient with Charcot Knees: A Case Report.
Case Report J Orthop Case Rep. 2020;10(2):9-12. PubMed
Comparison between quantitative and subjective assessments of chemotherapy-induced peripheral neuropathy in cancer patients: A prospective cohort study.
Original Phys Ther Res. 2020;23(2):166-171. PubMed
Transcutaneous application of carbon dioxide improves contractures after immobilization of rat knee joint.
Original Phys Ther Res. 2020;23(2):113-122. PubMed
Clinical Research
実施中の臨床研究
| 研究期間 | 臨床研究課題名 | 研究責任者 |
|---|---|---|
| 2021年12月〜 2028年12月 |
小児がん患者を対象としたがん治療が運動機能・生活の質に及ぼす影響についての前向き観察研究 | 酒井 良忠 |
| 2021年12月〜 2028年03月 |
下肢機能障害に対して従来型装具からカーボン製後方支柱付き短下肢装具ENAPLEに変更処方された小児の歩行機能に対する前向き観察研究 | 酒井 良忠 |
| 2021年12月〜 2028年03月 |
下肢機能障害に対してカーボン製後方支柱付き短下肢装具ENAPLEを新規で処方された小児の歩行機能に対する前向き観察研究 | 酒井 良忠 |
| 2026年03月〜 2027年03月 |
神経筋疾患患者を対象とした位相角の後方視的研究 | 原田 理沙 |
| 2025年01月〜 2028年11月 |
脳性麻痺に伴う痙性麻痺の内転筋痙縮に対する拡散型圧力波とボツリヌス毒素治療の併用効果に関する研究 | 原田 理沙 |
| 2021年11月〜 2031年03月 |
がんリハビリテーション処方を行った患者を対象としたがんロコモティブシンドロームの実態とADL/QOLの影響についての前向き観察研究 | 吉川 遼 |
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研究情報の公開(オプトアウト)
通常、臨床研究は文書もしくは口頭で説明を行い、患者さんからの同意(インフォームド・コンセント)を得て行われます。臨床研究のうち観察研究においては、たとえば患者さんへの侵襲や介入がなく、診療情報などの情報のみを用いて行う研究については、国が定めた倫理指針に基づき、必ずしも対象となる患者さんお一人ずつから直接同意を得るとはかぎりませんが、研究の目的を含めて研究の実施についての情報を公開し、さらに可能な限り拒否の機会を保障することが必要とされています。このような手法を「オプトアウト」といいます。
オプトアウトを用いた臨床研究は下記の通りです。研究のためにご自身のデータが使用されることを望まれない方は、各研究の担当者までお知らせください。
| 研究期間 | 研究担当者 | 研究課題名 | |
|---|---|---|---|
| 2026年3月〜2027年3月 | 原田理沙 | 神経筋疾患患者を対象とした位相角の後方視的研究 |