• Division of Adult Reconstruction and
  Joint Replacement / Results

• Results

Division of Adult Reconstruction and Joint Replacement

Kobe University Orthopaedic Adult Reconstruction and Joint Replacement Division are conducted by five faculties: Dr. Tomoyuki Matsumoto, Dr. Shinya Hayashi, Dr. Shingo Hashimoto, and Dr. Koji Takayama. Our main treatment and research target is osteoarthritis of the knee and hip joints. Therefore, cartilage biology study, such as regenerative medicine and biomechanics study for end-staged osteoarthritis, which needs knee and hip replacement surgery, is mainly focused in our group.

[Clinical research]

(1) Knee joint

Total knee arthroplasty (TKA) and unicompartmental knee arthroplasty (UKA) are mainly performed for end-stage osteoarthritis (OA). To obtain excellent postoperative outcomes, modified navigation system and an original offset-type tensor has been developed.
The modified navigation system enables not only accurate osteotomy, but also 3-D motion analysis. In addition, 3-D preoperative planning software is introduced to improve its accuracy. The offset-type tensor enables the assessment of soft tissue balance throughout range of motion (ROM) in the physiologic knee after TKA, with a reduced patellofemoral (PF) joint and femoral component in place. The accuracy of measurement and clinical relevance of this tensor have been reported, and this tensor has received high praise in Japan and all over the world. Together with this tensor and modified navigation system, accurate osteotomy and appropriate soft tissue balance are now available simultaneously. Furthermore evaluating the relationship between 3-D motion analysis, soft-tissue balance, and postoperative outcomes is possible.
To date, we have reported that intraoperative soft tissue balance is related to postoperative soft tissue balance and clinical outcomes. We have also reported the clinical outcomes with navigation system, patient satisfaction after TKA using the 2011 Knee Society Score (KSS), and the cause and treatment of prosthetic joint infection (PJI).
We have also evaluated the ligament balance in UKA using a tensor developed for UKA and studied the relationship between the ligament balance and postoperative clinical outcomes. In addition, we conducted a large-scale survey of Japanese lower limb alignment and reported changes in lower limb alignment due to age and knee osteoarthritis in the Japanese population.
Based on these research results, we are working on further improvement of postoperative outcomes and patient satisfaction.

(2) Hip Joint

Total hip arthroplasty (THA) is established treatment option for painful hip osteoarthritis. Good long-term clinical result is also expected with improvement of implant design, bearing surface, and materials. However, the difference of implant design affects the osteointegration area with the femoral stem, and may have a disadvantage for bone mineral density around the stem. Thus, we have evaluated bone mineral density of the femur after THA and investigated the ideal implant for ideal bearing force to the femur.
For developmental dysplasia of the hip, we are currently using the curved periacetabular osteotomy (CPO). CPO is a low-invasive osteotomy technique for hip abductor muscle with a 9-cm incision, but this technique depends on surgeon's experiences. We are introducing 3-D simulation software and navigation system when performing CPO to standardize this surgical technique.

[Basic research]

(1) Biomechanics

TKA is performed using the navigation system, tensor system, and 3-D preoperative planning software together. The relationships between preoperative condition, intraoperative evaluation with navigation system and offset type tensor, and postoperative outcomes are examined in the postoperative knee, with more physiological movement and higher flexion. We are also conducting collaborative research with Tokyo Women's Medical University (http://www.twmu.ac.jp/ABMES/FATS/) for developing a robot tensor, which measures soft tissue balance.

(2) Biology

Total joint replacement is an established surgical treatment option for osteoarthritis, but effective conservative treatment option is not established. Our research purpose is to clear the pathology of osteoarthritis and develop an effective treatment option, including drug and/or gene therapy.

• Division of Adult Reconstruction and
  Joint Replacement / Results

• Research

Original Research Article

(1) Kuroda Y, Hashimoto S, Hayashi S, Nakano N, Fujishiro T, Hiranaka T, Kuroda R, Matsumoto T. Fully hydroxyapatite-coated compaction broached and triple-tapered stem may reduce the risk of stress shielding after primary total hip arthroplasty. Arch Orthop Trauma Surg. 2022;142(12):4087-4093.

(2) Kuroda Y, Hashimoto S, Saito M, Matsumoto T, Nakano N, Kuroda R, Hayashi S. Femoro-Epiphyseal Acetabular Roof (FEAR) Index and Anterior Acetabular Coverage Correlate With Labral Length in Developmental Dysplasia of the Hip. Arthroscopy. 2022;38(2):374-381.

(3) Takashima Y, Hayashi S, Maeda T, Fukuda K, Onoi Y, Tachibana S, Ikuta K, Anjiki K, Fujita M, Kikuchi K, Kamenaga T, Kuroda R, Matsubara T. Histopathological changes of synovial tissue in rheumatoid arthritis patients treated with TNF-α inhibitors or IL-6 inhibitors. Clinical and Experimental Rheumatology. 2022;40(11):2060-2070.

(4) Onoi Y, Hiranaka T, Hida Y, Fujishiro T, Okamoto K, Matsumoto T, Kuroda R. Second-look Arthroscopic Findings and Clinical Outcomes after Adipose-derived Regenerative Cell Injection in Knee Osteoarthritis. Clin Orthop Surg. 2022;14(3):377-385.

(5) Kikuchi K, Haneda M, Hayashi S, Maeda T, Nakano N, Kuroda Y, Tsubosaka M, Kamenaga T, Fujita M, Ikuta K, Anjiki K, Tachibana S, Onoi Y, Matsumoto T, Kuroda R. P21 deficiency exhibits delayed endochondral ossification during fracture healing. Bone. 2022 ;165:116572

(6) Suda Y, Hiranaka T, Kamenaga T, Koide M, Fujishiro T, Okamoto K, Matsumoto T. Varus placement of the tibial component of Oxford unicompartmental knee arthroplasty decreases the risk of postoperative tibial fracture. Bone Joint J. 2022;(10):1118-1125.

(7) Fujita M, Matsumoto T, Hayashi S, Hashimoto S, Nakano N, Maeda T, Kuroda Y, Takashima Y, Kikuchi K, Anjiki K, Ikuta K, Onoi Y, Tachibana S, Matsushita T, Iwaguro H, Sobajima S, Hiranaka T, Kuroda R. Paracrine effect of the stromal vascular fraction containing M2 macrophages on human chondrocytes through the Smad2/3 signaling pathway. J Cell Physiol. 2022;237(9):3627-3639.

(8) Fujita M, Hayashi S, Kamenaga T, Fujishiro T, Matsumoto T, Kuroda R. Ligament preserving total hip arthroplasty prevents different leg length and femoral offset. Acta Ortop Bras. 2022;6;30(spe1): e242758.

(9) Fujita M, Matsumoto T, Nakano N, Ishida K, Kuroda Y, Maeda T, Hayashi S, Kuroda R. Rotational mismatch between femoral and tibial components should be avoided in JOURNEY II bi-cruciate stabilized total knee arthroplasty. Knee. 2022;38: 69-75.

(10) Anjiki K, Kamenaga T, Hayashi S, Hashimoto S, Kuroda Y, Nakano N, Fujishiro T, Hiranaka T, Niikura T, Kuroda R, Matsumoto T. Effectiveness of an accelerometer-based portable navigation for intraoperative adjustment of leg length discrepancy in total hip arthroplasty in the supine position. J Orthop Sci. 2022 ;27(1):169-175.

(11) Kamenaga T, Hiranaka T, Nakano N, Hayashi S, Fujishiro T, Okamoto K, Kuroda R, Matsumoto T. Short distance from the keel to the posterior tibial cortex is associated with fracture after cementless Oxford UKA in Asian patients. Knee Surg Sports Traumatol Arthrosc. 2022;30(4):1220-1230.

(12) Kamenaga T, Hiranaka T, Hida Y, Nakano N, Kuroda Y, Tsubosaka M, Hayashi S, Kuroda R, Matsumoto T. Lateral osteoarthritis progression is associated with a postoperative residual tibiofemoral subluxation in Oxford UKA. Knee Surg Sports Traumatol Arthrosc. 2022 ;30(9):3236-3243.

(13) Kamenaga T, Nakano N, Ishida K, Tsubosaka M, Kuroda Y, Hayashi S, Matsushita T, Niikura T, Kuroda R, Matsumoto T. Preoperative uncorrectable tibiofemoral subluxation can worsen clinical outcomes after fixed-bearing unicompartmental knee arthroplasty: a retrospective analysis. Arch Orthop Trauma Surg. 2022;142(10):2865-2874.

(14) Tachibana S, Muratsu H, Tsubosaka M, Maruo A, Miya H, Kuroda R, Matsumoto T. Evaluation of consistency of patient-satisfaction score in the 2011 Knee Society Score to other patient-reported outcome measures. J Orthop Sci. 2022 ;27(3):652-657.

(15) Hayashi S, Hashimoto S, Kuroda Y, Matsumoto T, Kamenaga T, Kuroda R. Combination　of Anterior Acetabular Coverage and Femoral Head Shape Predicts Femoroacetabular　Impingement After Periacetabular Osteotomy. J Arthroplasty. 2022;37(2):219-225.

(16) Hayashi S, Kuroda Y, Nakano N, Matsumoto T, Kamenaga T, Maeda T, Niikura T, Kuroda R. Peri-prosthetic bone remodeling of hydroxyapatite-coated compaction short stem was not affected by stem alignment. J Orthop Surg Res. 2022；3;17(1):131.

(17) Hayashi S, Hashimoto S, Kuroda Y, Nakano N, Matsumoto T, Kamenaga T, Kuroda R. Anterior acetabular coverage and femoral head-neck measurements predict postoperative anterior impingement: A simulation study. J Orthop Res. 2022 ;40(10):2440-2447.

(18) Hayashi S, Hashimoto S, Kuroda Y, Nakano N, Matsumoto T, Kamenaga T, Niikura T, Kuroda R. Hydroxyapatite-coated compaction short stem represents a characteristic pattern of peri-prosthetic bone remodelling after total hip arthroplasty. Arch Orthop Trauma Surg. 2022;142(10):2903-2910.

(19) Hayashi S, Kuroda Y, Nakano N, Matsumoto T, Kamenaga T, Maeda T, Kuroda R A combination of acetabular coverage and femoral head–neck measurements can help diagnose femoroacetabular impingement. Journal of Hip Preservation Surgery, 2022. 1:1-7

(20) Hayashi S, Matsubara T, Fukuda K, Maeda T, Funahashi K, Hashimoto M, Takashima Y, Kikuchi K, Fujita M, Matsumoto T, Kuroda. A genome-wide association study identifying single nucleotide polymorphisms in the PPFIBP2 gene was predictive for interstitial lung disease in rheumatoid arthritis patients..Rheumatol Adv Pract. 2022 Oct 29;6(3):rkac088

(21) Hayashi S, Matsubara T, Maeda T, Fukuda K, Funahashi K, Hashimoto M, Tsumiyama K, Kamenaga T, Takashima Y, Matsumoto T, Tachibana S, Kuroda R.Comparison of the inhibitory effect of tocilizumab and etanercept on the progression of joint erosion in rheumatoid arthritis treatment. Sci Rep. 2022 ;20;12(1):17524.

(22) Matsumoto T, Takashima Y, Takayama K, Ishida K, Nakano N, Kuroda Y, Tsubosaka M, Kamenaga T, Matsushita T, Niikura T, Hayashi S, Kuroda R. Comparison between single and multi-radius prostheses used in modified kinematically aligned cruciate-retaining total knee arthroplasty. J Knee Surg. 2022, 35(9): 1004-1009

(23) Kuroda Y, Young M, Shoman H, Punnoose A, Norrish AR, Khanduja V. Advanced rehabilitation technology in orthopaedics-a narrative review. Int Orthop. 2021;45(8):1933-1940.

(24) Kuroda Y, Hashimoto S, Saito M, Hayashi S, Nakano N, Matsushita T, Niikura T, Kuroda R, Matsumoto T. Obesity is associated with less favorable outcomes following hip arthroscopic surgery: a systematic review and meta-analysis. Knee Surg Sports Traumatol Arthrosc. 2021;29(5):1483-1493.

(25) Kuroda Y, Takayama K, Ishida K, Hayashi S, Hashimoto S, Tsubosaka M, Kamenaga T, Matsushita T, Niikura T, Kuroda R, Matsumoto T. Radiographic Comparison of the Mechanical Axis Including Calcaneus to the Conventional Mechanical Axis in Medial Unicompartmental Knee Arthroplasty. J Knee Surg. 2021;34(9):930-935.

(26) Nakano N, Kuroda Y, Maeda T, Takayama K, Hashimoto S, Ishida K, Hayashi S, Hoshino Y, Matsushita T, Niikura T, Kuroda R, Matsumoto T. Modern Femoral Component Design in Total Knee Arthroplasty Shows a Lower Patellar Contact Force During Knee Flexion Compared With Its Predecessor. Knee. 2021;30:1-8.

(27) Nakano N, Takayama K, Kuroda Y, Maeda T, Hashimoto S, Ishida K, Hayashi S, Hoshino Y, Matsushita T, Niikura T, Kuroda R, Matsumoto T. Preoperative Varus Deformity of the Knee Affects the Intraoperative Joint Gap in Unicompartmental Knee Arthroplasty. Knee. 2021;32:90-96.

(28) Nakano N, Kubo S, Sato Y, Takayama K, Mizuno K, Kuroda R, Matsumoto T. Knee Flexion Angle Following Total Knee Arthroplasty Relates to a Preoperative Range of Motion of the Hip. Indian J Orthop. 2021;55(4):948-952.

(29) Nakano N, Mizuno K, Takayama K, Hayashi S, Kuroda R, Matsumoto T. Outcomes of Total Knee Replacement with the Use of a NexGen MIS Tibial Component (Mini-keel): A Systematic Review. Acta Orthop Belg. 2021;87:1-10.

(30) Fujita M, Hiranaka T, Brang Mai, Kamenaga T, Tsubosaka M, Takayama K, Kuroda R, Matsumoto T. External rotation of the tibial component should be avoided in lateral unicompartmental knee arthroplasty. Knee. 2021; 30: 70-77.

(31) Takashima Y, Matsumoto T, Takayama K, Nakano N, Kuroda Y, Tsubosaka M, Kamenaga T, Kikuchi K, Fujita M, Ikuta K, Anjiki K, Hayashi S, Hashimoto S, Maeda T, Inokuchi T, Toda M, Chin T, Kuroda R. Comparison of Clinical and Biomechanical Outcomes between the Kinematic and Mechanical Alignment Methods in Total Knee Arthroplasty: Protocol for a Multicenter Randomized Controlled Trial. Contemp Clin Trials Commun. 2021;22:100775.

(32) Takashima Y, Hayashi S, Fukuda K, Maeda T, Tsubosaka M, Kamenaga T, Kikuchi K, Fujita M, Kuroda Y, Hashimoto S, Nakano N, Matsumoto T, Kuroda R. Susceptibility of cyclin-dependent kinase inhibitor 1-deficient mice to rheumatoid arthritis arising from interleukin-1β-induced inflammation. Scientific Reports. 2021;11(1):12516.

(33) Tsubosaka M, Ishida K, Kodato K, Shibanuma N, Hayashi S, Kurosaka M, Kuroda R, Matsumoto T. Mid-flexion stability in the anteroposterior plane is achieved with a medial congruent insert in cruciate-retaining total knee arthroplasty for varus osteoarthritis. Knee Surg Sports Traumatol Arthrosc. 2021;29(2):467-473.

(34) Tsubosaka M, Kamenaga T, Kuroda Y, Takayama K, Hashimoto S, Ishida K, Hayashi S, Kuroda R, Matsumoto T. Accelerometer-Based Portable Navigation System Is Useful for Tibial Bone Cutting in Modified Kinematically Aligned Total Knee Arthroplasty. J Knee Surg. 2021;34(8):870-876.

(35) Tsubosaka M, Maruyama M, Huang EE, Zhang N, Utsunomiya T, Gao Q, Shen H, Li X, Kushioka J, Hirata H, Yao Z, Yang YP, Goodman SB. Effect on Osteogenic Differentiation of Genetically Modified IL4 or PDGF-BB Over-Expressing and IL4-PDGF-BB Co-Over-Expressing Bone Marrow-Derived Mesenchymal Stromal Cells In Vitro. Bioengineering (Basel). 2021;8(11):165.

(36) Kamenaga T, Nakano N, Takayama K, Tsubosaka M, Takashima Y, Kikuchi K, Fujita M, Kuroda Y, Hashimoto S, Hayashi S, Niikura T, Kuroda R, Matsumoto T. Comparison of plantar pressure distribution during walking and lower limb alignment between modified kinematically and mechanically aligned total knee arthroplasty. J Biomech. 2021;120:110379.

(37) Kamenaga T, Kuroda Y, Nagai K, Tsubosaka M, Takashima Y, Kikuchi K, Fujita M, Ikuta K, Anjiki K, Maeda T, Nakano N, Takayama K, Hashimoto S, Hayashi S, Matsushita T, Niikura T, Kuroda R, Matsumoto T. Cryopreserved human adipose-derived stromal vascular fraction maintains fracture healing potential via angiogenesis and osteogenesis in an immunodeficient rat model. Stem Cell Res Ther. 2021;12(1):110.

(38) Hayashi S, Hashimoto S, Kuroda Y, Nakano N, Matsumoto T, Ishida K, Shibanuma N, Kuroda R. Robotic-arm assisted THA can achieve precise cup positioning in developmental dysplasia of the hip : a case control study. Bone Joint Res 2021;10(10):629-638.

(39) Hayashi S, Hashimoto S, Kuroda Y, Nakano N, Matsumoto T, Ishida K, Shibanuma N, Kamenaga T, Kuroda R. Accuracy of cup position following robot-assisted total hip arthroplasty may be associated with surgical approach and pelvic tilt. Sci Rep. 2021;11(1):7578.

(40) Hayashi S, Matsubara T, Fukuda K, Maeda T, Funahashi K, Hashimoto M, Kamenaga T, Takashima Y, Kuroda R. A genome-wide association study identifying the SNPs predictive of rapid joint destruction in patients with rheumatoid arthritis. Biomed Rep. 2021;14(3):31

(41) Ichise Y, Saegusa J, Tanaka-Natsui S, Naka I, Hayashi S, Kuroda R, Morinobu A.Soluble CD14 Induces Pro-inflammatory Cytokines in Rheumatoid Arthritis Fibroblast-Like Synovial Cells via Toll-Like Receptor 4. Cells. 2020;9(7):1689.

(42) Hayashi S, Hashimoto S, Matsumoto T, Takayama K, Shibanuma N, Ishida K, Niikura T, Nishida K, Kuroda R. Postoperative excessive anterior acetabular coverage is associated with decrease in range of motion after periacetabular osteotomy.
Hip Int. 2021;31(5):669-675.

(43) Takeuchi K, Hashimoto S, Matsumoto T, Hayashi S, Takayama K, Kuroda R. Recovery of activity level following total hip arthroplasty in patients less than 60 years of age.Hip Int. 2021;31(5):632-636.

(44) Kuroda Y, Rai A, Saito M, Khanduja V. Anatomical variation of the Psoas Valley: a scoping review. BMC Musculoskelet Disord. 2020;21(1):219.

(45) Kuroda Y, Saito M, Çınar E, Norrish A, Khanduja V. Patient-related Risk Factors Associated with Less Favorable Outcomes following Hip Arthroscopy: A Scoping Review. Bone Joint J. 2020;102-B(7):822-831.

(46) Kuroda Y, Saito M, Sunil Kumar KH, Malviya A, Khanduja V. Hip Arthroscopy and Borderline Developmental Dysplasia of the Hip: A Systematic Review. Arthroscopy. 2020;36(9):2550-2567.

(47) Kuroda Y, Hayashi S, Hashimoto S, Matsumoto T, Takayama K, Kuroda R. Preoperative predictors of health-related quality of life after revision total hip arthroplasty for aseptic loosening. Indian J Orthop. 2020;54(4):463-468.

(48) Kuroda Y, Takayama K, Hayashi S, Hashimoto S, Matsushita T, Niikura T, Kuroda R, Matsumoto T. Varus deformity in the proximal tibia and immediate postoperative varus alignment result in varus progression in limb alignment in the long term after total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc. 2020; 28(10):3287-3293.

(49) Kuroda Y, Takayama K, Hayashi S, Hashimoto S, Tsubosaka M, Kamenaga T, Matsushita T, Niikura T, Kuroda R, Matsumoto T. Mobile-bearing insert reduced patellar contact force at knee flexion during posterior stabilized total knee arthroplasty. Clin Biomech (Bristol, Avon). 2020;76:105022.

(50) Kamenaga T, Takayama K, Ishida K, Hayashi S, Kuroda R, Matsumoto T. Central Implantation of the Femoral Component Relative to the Tibial Insert Improves Clinical Outcomes in Fixed-Bearing Unicompartmental Knee Arthroplasty. J Arthroplasty. 2020;35(11):3108-3116.

(51) Kamenaga T, Hayashi S, Hashimoto S, Fukuda K, Takayama K, Tsubosaka M, Takashima Y, Niikura T, Kuroda R, Matsumoto T. Pelvic morphology medial to the femoral head center predicts anterior coverage and range of motion after curved periacetabular osteotomy. J Orthop Res. 2020;38(9):2031-2039.

(52) Kamenaga T, Hashimoto S, Hayashi S, Takayama K, Niikura T, Kuroda R, Matsumoto T. Larger Acetabular Labrum Is Associated With Hip Dysplasia, Joint Incongruence, and Clinical Symptoms. Arthroscopy. 2020;36(9):2446-2453.

(53) Kamenaga T, Hida Y, Hiranaka T, Tanaka T, Okimura K, Tsubosaka M, Kuroda Y, Nakano N, Hayashi S, Niikura T, Kuroda R, Matsumoto T. Extent of in vivo sagittal bearing movement and its relationship with tibial posterior slopes in Oxford mobile-bearing unicompartmental knee arthroplasty. Clin Biomech (Bristol, Avon). 2020;80:105148.

(54) Kamenaga T, Hayashi S, Hashimoto S, Takayama K, Fujishiro T, Hiranaka T, Kuroda R, Matsumoto T. Intraoperative pelvic movement is associated with the body mass index in patients undergoing total hip arthroplasty in the supine position. J Orthop Sci. 2020;25(3):446-451.

(55) Matsumoto T, Takayama K, Ishida K, Kuroda Y, Tsubosaka M, Muratsu H, Hayashi S, Hashimoto S, Matsushita T, Niikura T, Kuroda R.　Intraoperative Soft Tissue Balance/Kinematics and Clinical Evaluation of Modified Kinematically versus Mechanically Aligned Total Knee Arthroplasty. J Knee Surg. 2020;33(8):777-784.

(56) Tsubosaka M, Matsumoto T, Sobajima S, Matsushita T, Iwaguro H, Kuroda R. The influence of adipose-derived stromal vascular fraction cells on the treatment of knee osteoarthritis. BMC Musculoskelet Disord. 2020;21(1):207.

(57) Tsubosaka M, Kihara S, Hayashi S, Nagata J, Kuwahara T, Fujita M, Kikuchi K, Takashima Y, Kamenaga T, Kuroda Y, Takeuchi K, Fukuda K, Takayama K, Hashimoto S, Matsumoto T, Niikura T, Tabata Y, Kuroda R. Gelatin hydrogels with eicosapentaenoic acid can prevent osteoarthritis progression in vivo in a mouse model. J Orthop Res. 2020;38(10):2157-2169.

(58) Tsubosaka M, Muratsu H, Nakano N, Kamenaga T, Kuroda Y, Miya H, Kuroda R, Matsumoto T. Sequential changes in lower extremity function after total knee arthroplasty. J Orthop Surg (Hong Kong). 2020;28(3):2309499020965645.

(59) Takashima Y, Takayama K, Ishida K, Muratsu H, Matsushita T, Niikura T, Kuroda R, Matsumoto T. Comparison of intraoperative soft tissue balance measurement between two tensor systems in total knee arthroplasty. Knee. 2020;27(3):1071-1077.

(60) Hayashi S, Hashimoto S, Takayama K, Matsumoto T, Kamenaga T, Fujishiro T, Hiranaka T, Niikura T, Kuroda R. Evaluation of the accuracy of acetabular cup orientation using the accelerometer-based portable navigation system. J Orthop Sci. 2020;25(4):612-617.

(61) Hayashi S, Hashimoto S, Matsumoto T, Takayama K, Niikura T, Kuroda R. Risk factors of thigh pain following total hip arthroplasty with short, tapered-wedge stem. Int Orthop. 2020;44(12):2553-2558.

(62) Hayashi S, Hashimoto S, Matsumoto T, Takayama K, Kamenaga T, Niikura T, Kuroda R. Preoperative anterior coverage of the medial acetabulum can predict postoperative anterior coverage and range of motion after periacetabular osteotomy: a cohort study. J Orthop Surg Res. 2020;15(1):312.

(63) Hayashi S, Hashimoto S, Matsumoto T, Takayama K, Kamenaga T, Niikura T, Kuroda R. Overcorrection of the acetabular roof angle or anterior center–edge angle may cause decrease of range of motion after curved periacetabular osteotomy. J Hip Preserv Surg. 2020;7(3):583-590..

(64) Nakano N, Shoman H, Khanduja V. Treatment Strategies for Ischiofemoral Impingement - A Systematic Review. Knee Surg Sports Traumatol Arthrosc. 2020; 28(9):2772-2787.

(65) Nakano N, Shoman H, Olavarria F, Matsumoto T, Kuroda R, Khanduja V. Why Are Patients Dissatisfied Following A Total Knee Replacement?: A Systematic Review. Int Orthop. 2020; 44(10):1971-2007.

(66) Suda Y, Takayama K, Ishida K, Hayashi S, Hashimoto S, Niikura T, Matsushita T, Kuroda R, Matsumoto T: Improved implant alignment accuracy with an accelerometer-based portable navigation system in medial unicompartmental knee arthroplasty. Knee Surg Sports Traumatol Arthrosc. 2020;28(9):2917-2923.

(67) Tsubosaka M, Muratsu H, Takayama K, Maruo A, Miya H, Kuroda R, Matsumoto T: Effect of intraoperative soft tissue balance on postoperative recovery of ambulatory and balancing function in posterior-stabilized total knee arthroplasty. J Orthop Sci. 2019, 24:507-513.

(68) Kuroda Y, Takayama K, Ishida K, Hayashi S, Hashimoto S, Nishida K, Matsushita T, Niikura T, Kuroda R, Matsumoto T: Influence of limb alignment and prosthetic orientation on patient-reported clinical outcomes in total knee arthroplasty. J Orthop Sci. 2019, 24:668-673.

(69) Kuroda Y, Matsumoto T, Hayashi S, Hashimoto S, Takayama K, Kirizuki S, Tsubosaka M, Kamenaga T, Takashima Y, Matsushita T, Niikura T, Kuroda R: Intra-articular autologous uncultured adipose-derived stromal cell transplantation inhibited the progression of cartilage degeneration. J Orthop Res. 2019;37:1376-1386.

(70) Kawakami Y, Hambright WS, Takayama K, Mu X, Lu A, Cummins JH, Matsumoto T, Yurube T, Kuroda R, Kurosaka M, Fu FH, Robbins PD, Niedernhofer LJ, Huard J: Rapamycin Rescues Age-Related Changes in Muscle-Derived Stem/Progenitor Cells from Progeroid Mice. Mol Ther Methods Clin Dev. 2019;14:64-76.

(71) Kamenaga T, Takayama K, Ishida K, Muratsu H, Hayashi S, Hashimoto S, Kuroda Y, Tsubosaka M, Takashima Y, Matsushita T, Niikura T, Kuroda R, Matsumoto T: Medial knee stability at flexion increases tibial internal rotation and knee flexion angle after posterior-stabilized total knee arthroplasty. Clin Biomech (Bristol, Avon).2019;68:16-22.

(72) Kamenaga T, Hiranaka T, Takayama K, Tsubosaka M, Kuroda R, Matsumoto T: Adequate Positioning of the Tibial Component Is Key to Avoiding Bearing Impingement in Oxford Unicompartmental Knee Arthroplasty. J Arthroplasty;2019, 34:2606-2613.

(73) Kamenaga T, Hiranaka T, Nakanishi Y, Takayama K, Kuroda R, Matsumoto T: Valgus Subsidence of the Tibial Component Caused by Tibial Component Malpositioning in Cementless Oxford Mobile-Bearing Unicompartmental Knee Arthroplasty. J Arthroplasty. 2019;34:3054-3060.

(74) Kamenaga T, Hayashi S, Hashimoto S, Matsumoto T, Takayama K, Fujishiro T, Hiranaka T, Niikura T, Kuroda R: Accuracy of cup orientation and learning curve of the accelerometer-based portable navigation system for total hip arthroplasty in the supine position. J Orthop Surg (Hong Kong).2019;27:2309499019848871

(75) Hayashi S, Fukuda K, Maeda T, Chinzei N, Kihara S, Miura Y, Sakai Y, Hashimoto S, Matsumoto T, Takayama K, Niikura T, Kuroda R: Denosumab Treatment Improved Health-Related Quality of Life in Osteoporosis: A Prospective Cohort Study. JBMR Plus, 2019, 3:e10191

(76) Fukuda K, Miura Y, Maeda T, Hayashi S, Kuroda R: Expression profiling of genes in rheumatoid fibroblast-like synoviocytes regulated by tumor necrosis factor-like ligand 1A using cDNA microarray analysis. Biomed Rep. 2019;1:1-5.

(77) Haneda M, Hayashi S, Matsumoto T, Hashimoto S, Takayama K, Chinzei N, Kihara S, Takeuchi K, Nishida K, Kuroda R: Depletion of aquaporin 1 decreased ADAMTS4 expression in human chondrocytes. Mol Med Rep, 2018, 17:4874-4882.

(78) Kamenaga T, Muratsu H, Kanda Y, Miya H, Kuroda R, Matsumoto T: The Influence of Postoperative Knee Stability on Patient Satisfaction in Cruciate-Retaining Total Knee Arthroplasty. J Arthroplasty, 2018, 33:2475-2479.

(79) Kodato K, Ishida K, Shibanuma N, Toda A, Takayama K, Oka S, Hayashi S, Hashimoto S, Kurosaka M, Kuroda R, Matsumoto T: Prothrombin time-international normalized ratio is a useful marker for edoxaban efficacy in preventing venous thromboembolism after total knee arthroplasty. Eur J Orthop Surg Traumatol, 2018, 28:103-108,

(80) Toda A, Tei K, Matsumoto T, Ishida K, Sasaki H, Kodato K, Nishizawa Y, Kirizuki S, Shibanuma N, Tateishi H, Kuroda R, Kurosaka M: Post-cam clunk syndrome after posterior stabilized total knee arthroplasty as a sign of early femoral component loosening. Asia Pac J Sports Med Arthrosc Rehabil Technol, 2018, 11:19-21,

(81) Ueha T, Oe K, Miwa M, Hasegawa T, Koh A, Nishimoto H, Lee SY, Niikura T, Kurosaka M, Kuroda R, Sakai Y: Increase in carbon dioxide accelerates the performance of endurance exercise in rats. J Physiol Sci, 2018, 68:463-470,

(82) Matsumoto T, Takayama K, Muratsu H, Ishida K, Hashimoto S, Hayashi S, Kuroda R: Relatively Loose Flexion Gap Improves Patient-Reported Clinical Scores in Cruciate-Retaining Total Knee Arthroplasty. J Knee Surg, 2018, 31:573-579.

(83) Tsubosaka M, Hayashi S, Hashimoto S, Takayama K, Kuroda R, Matsumoto T: Patients with a Dorr type C femoral bone require attention for using a Summit cementless stem: Results of total hip arthroplasty after a minimum follow-up period of 5 years after insertion of a Summit cementless stem. J Orthop Sci, 2018, 23:671-675,

(84) Uesugi Y, Sakai T, Seki T, Hayashi S, Nakamura J, Inaba Y, Takahashi D, Sasaki K, Motomura G, Mashima N, Kabata T, Sudo A, Jinno T, Ando W, Nagoya S, Yamamoto K, Nakasone S, Ito H, Yamamoto T, Sugano N: Quality of life of patients with osteonecrosis of the femoral head: a multicentre study. Int Orthop, 2018, 42:1517-1525,

(85) Takayama K, Ishida K, Muratsu H, Kuroda Y, Tsubosaka M, Hashimoto S, Hayashi S, Matsushita T, Niikura T, Kuroda R, Matsumoto T: The medial tibial joint line elevation over 5 mm restrained the improvement of knee extension angle in unicompartmental knee arthroplasty. Knee Surg Sports Traumatol Arthrosc, 2018, 26:1737-1742,

(86) Nishida K, Matsushita T, Takayama K, Tanaka T, Miyaji N, Ibaraki K, Araki D, Kanzaki N, Matsumoto T, Kuroda R: Intraperitoneal injection of the SIRT1 activator SRT1720 attenuates the progression of experimental osteoarthritis in mice. Bone Joint Res, 2018, 7:252-262,

(87) Tsubosaka M, Muratsu H, Takayama K, Miya H, Kuroda R, Matsumoto T: Comparison of Intraoperative Soft Tissue Balance Between Cruciate-Retaining and Posterior-Stabilized Total Knee Arthroplasty Performed by a Newly Developed Medial Preserving Gap Technique. J Arthroplasty, 2018, 33:729-734,

(88) Fukuda K, Miura Y, Maeda T, Hayashi S, Kuroda R: Decoy receptor 3 down-regulates centrosomal protein 70 kDa specifically in rheumatoid synovial fibroblasts. Mod Rheumatol, 2018, 28:287-292,

(89) Ishida K, Shibanuma N, Matsumoto T, Toda A, Oka S, Kodato K, Takayama K, Kurosaka M, Kuroda R: Tibiofemoral rotational alignment affects flexion angles in navigated posterior-stabilized total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc, 2018, 26:1532-1539,

(90) Kirizuki S, Matsumoto T, Ueha T, Uefuji A, Inokuchi T, Takayama K, Hashimoto S, Hayashi S, Matsushita T, Kuroda R: The Influence of Ruptured Scar Pattern on the Healing Potential of Anterior Cruciate Ligament Remnant Cells. Am J Sports Med, 2018, 46:1382-1388,

(91) Uesugi Y, Koyanagi J, Takagi K, Yamaguchi R, Hayashi S, Nishii T: Exercise Therapy Interventions in Patients With Hip Osteoarthritis: Comparison of the Effects of DVD and Website-Based Interventions. JMIR Rehabil Assist Technol, 2018, 5:e10,

(92) Tani I, Nakano N, Takayama K, Ishida K, Kuroda R, Matsumoto T: Navigated Total Knee Arthroplasty for Osteoarthritis with Extra-Articular Deformity. Acta Ortop Bras, 2018, 26:170-174,

(93) Nagai K, Muratsu H, Kanda Y, Tsubosaka M, Kamenaga T, Miya H, Matsushita T, Niikura T, Kuroda R, Matsumoto T: Intraoperative soft tissue balance using novel medial preserving gap technique in posterior-stabilized total knee arthroplasty: comparison to measured resection technique. Knee Surg Sports Traumatol Arthrosc, 2018, 26:3474-3481,

(94) Ishida K, Shibanuma N, Kodato K, Toda A, Sasaki H, Takayama K, Hayashi S, Hashimoto S, Matsushita T, Niikura T, Kurosaka M, Kuroda R, Matsumoto T: A prospective randomized comparative study to determine appropriate edoxaban administration period, to prevent deep vein thromboembolism in patients with total knee arthroplasty. J Orthop Sci, 2018, 23:1005-1010,

(95) Kuroda Y, Takayama K, Ishida K, Hayashi S, Hashimoto S, Tsubosaka M, Matsushita T, Niikura T, Nishida K, Kuroda R, Matsumoto T: Medial joint line elevation of the tibia measured during surgery has a significant correlation with the limb alignment changes following medial unicompartmental knee arthroplasty. Knee Surg Sports Traumatol Arthrosc, 2018, 26:3468-3473,

(96) Hayashi S, Hashimoto S, Matsumoto T, Takayama K, Shibanuma N, Ishida K, Nishida K, Kuroda R: Computer-assisted surgery prevents complications during peri-acetabular osteotomy. Int Orthop, 2018, 42:2555-2561,

(97) Takeuchi K, Hayashi S, Matumoto T, Hashimoto S, Takayama K, Chinzei N, Kihara S, Haneda M, Kirizuki S, Kuroda Y, Tsubosaka M, Nishida K, Kuroda R: Downregulation of aquaporin 9 decreases catabolic factor expression through nuclear factorkappaB signaling in chondrocytes. Int J Mol Med, 2018, 42:1548-1558,

(98) Ishida K, Shibanuma N, Takayama K, Kurosaka M, Kuroda R, Matsumoto T: Posterior Reference Position Affects Intraoperative Kinematic and Soft Tissue Balance in Navigated Posterior-Stabilized Total Knee Arthroplasty. J Arthroplasty, 2018, 33:2851-2857,

(99) Sasaki H, Ishida K, Shibanuma N, Takayama K, Hayashi S, Hashimoto S, Niikura T, Kurosaka M, Kuroda R, Matsumoto T: Comparison of Coronal Prosthetic Alignment After Total Knee Arthroplasty Using 3 Computer-Assisted Navigation Systems. Orthopedics, 2018, 41:e621-e628,

Book Chapter

(1) Kuroda Y, Rai A, Matsumoto K, Khanduja V. Current Concepts in the Management of Femoroacetabular Impingement. Advances in Specialist Hip Surgery. Drescher WR, et al (Eds.), Springer, 2021, 115-124.