業績

   

原著論文（全て査読あり）

 

2024年度

  • Miyamoto Y, Kikuta J, Matsui T, Hasegawa T, Fujii K, Okuzaki D, Liu YC, Yoshioka T, Seno S, Motooka D, Uchida Y, Yamashita E, Kobayashi S, Eguchi H, Morii E, Tryggvason K, Shichita T, Kayama H, Atarashi K, Kunisawa J, Honda K, Takeda K, Ishii M. Periportal macrophages protect against commensal-driven liver inflammation. Nature. 2024 629(8013):901-909. 
 

2023年度

  • Otaki N, Motomura Y, Kelly T, Mochizuki M, Takeno N, Koyasu S, Tamamitsu M, Sugihara F, Kikuta J, Kitamura H, Shiraishi Y, Miyanohara J, Nagano Y, Saita Y, Ogura T, Asano K, Minoda A, Moro K, Activation of ILC2s through constitutive IFNγ signaling reduction leads to spontaneous pulmonary fibrosis. Nat Commun. 2023 14(1):8120.
  • Takeda N, Tsuchiya A, Mito M, Natsui K, Natusi Y, Koseki Y, Tomiyoshi K, Yamazaki F, Yoshida Y, Abe H, Sano M, Kido T, Yoshioka Y, Kikuta J, Itoh T, Nishimura K, Ishii M, Ochiya T, Miyajima A, Terai S. Analysis of distribution, collection, and confirmation of capacity dependency of small extracellular vesicles toward a therapy for liver cirrhosis. Inflamm Regen. 2023 43(1):48.
  • Abe S, Asahi T, Hara T, Cui G, Shimba A, Tani- Ichi S, Yamada K, Miyazaki K, Miyachi H, Kitano S, Nakamura N, Kikuta J, Vandenbon A, Miyazaki M, Yamada R, Ohteki T, Ishii M, Sexl V, Nagasawa T, Ikuta K. Hematopoietic cell-derived IL-15 supports NK cell development in scattered and clustered localization within the bone marrow. Cell Rep. 2023 42(9):113127.
  • Shimizu K, *Kikuta J, Ohta Y, Uchida Y, Miyamoto Y, Morimoto A, Yari S, Sato T, Kamakura T, Oshima K, Imai R, Liu Y, Okuzaki D, Hara T, Motooka D, Emoto N, Inohara H, *Ishii M, Single-cell transcriptomics of human cholesteatoma identifies an activin A-producing osteoclastogenic fibroblast subset inducing bone destruction. Nat Commun. 2023 14(1):4417. (*Co-corresponding author)
 
 --------アコーディオンパーツを削除する際は、この一行上の空白行から[アコーディオン終了]まで全てを選択し削除してください--------
2022年度以前
  • Yari S, *Kikuta J, Shigyo H, Miyamoto Y, Okuzaki D, Furusawa Y, Minoshima M, Kikuchi K, *Ishii M. JAK inhibition ameliorates bone destruction by simultaneously targeting mature osteoclasts and their precursors. Inflamm Regen. 2023 43:18. (*Co-corresponding author)
  • Koike T, Fujii K, Kometani K, Butler NS, Funakoshi K, Yari S, Kikuta J, Ishii M, Kurosaki T, Ise W. Progressive differentiation toward the long-lived plasma cell compartment in the bone marrow. J Exp Med. 2023 220:e20221717. 
  • Matsui T, Iwasa A, Mimura M, Taniguchi S, Sudo T, Uchida Y, Kikuta J, Morizono H, Horii R, Motoyama Y, Morii E, Ohno S, Kiyota Y, Ishii M. Label-free multiphoton excitation imaging as a promising diagnostic tool for breast cancer. Cancer Sci. 2022 113:2916-2925. 
  • Kaneko C, Tsutsui H, Ozeki K, Honda M, Haraya K, Narita Y, Sakurai M, Kikuta J, Tabo M, Ishii M. In vivo imaging with two-photon microscopy to assess the tumor-selective binding of an anti-CD137 switch antibody. Sci Rep. 2022 12:4907. 
  • Narazaki A, Shimizu R, Yoshihara T, Kikuta J, Sakaguchi R, Tobita S, Mori Y, Ishii M, Nishikawa K. Determination of the physiological range of oxygen tension in bone marrow monocytes using two-photon phosphorescence lifetime imaging microscopy. Sci Rep. 2022 12:3497. 
  • Uenaka M, Yamashita E, *Kikuta J, Morimoto A, Ao T, Mizuno H, Furuya M, Hasegawa T, Tsukazaki H, Sudo T, Nishikawa K, Okuzaki D, Motooka D, Kosaka N, Sugihara F, Boettger T, Braun T, Ochiya T, *Ishii M. Osteoblast-derived vesicles induce a switch from bone-formation to bone-resorption in vivo. Nat Commun. 2022 13:1066. (*Co-corresponding author)
  • Nishikawa K, Seno S, Yoshihara T, Narazaki A, Sugiura Y, Shimizu R, Kikuta J, Sakaguchi R, Suzuki N, Takeda N, Semba H, Yamamoto M, Okuzaki D, Motooka D, Kobayashi Y, Suematsu M, Koseki H, Matsuda H, Yamamoto M, Tobita S, Mori Y, Ishii M. Osteoclasts adapt to physioxia perturbation through DNA demethylation. EMBO Rep. 2021 22:e53035. 
  • Tsukazaki H, *Kikuta J, Ao T, Morimoto A, Fukuda C, Tsuda E, Minoshima M, Kikuchi K, Kaito T, *Ishii M. Anti-Siglec-15 antibody suppresses bone resorption by inhibiting osteoclast multinucleation without attenuating bone formation. Bone. 2021 152:116095. (*Co-corresponding author)
  • Momiuchi Y, Motomura Y, Suga E, Mizuno H, Kikuta J, Morimoto A, Mochizuki M, Otaki N, Ishii M, ＊Moro K. Group 2 innate lymphoid cells in bone marrow regulate osteoclastogenesis in a reciprocal manner via RANKL, GM-CSF, and IL-13. Int Immunol. 2021 33:573-585. 
  • Koga T, Sasaki F, Saeki K, Tsuchiya S, Okuno T, Ohba M, Ichiki T, Iwamoto S, Uzawa H, Kitajima K, Meno C, Nakamura E, Tada N, Fukui Y, Kikuta J, Ishii M, Sugimoto Y, Nakao M, Yokomizo T. Expression of leukotriene B4 receptor 1 defines functionally distinct DCs that control allergic skin inflammation. Cell Mol Immunol. 2021 18:1437-1449. 
  • Sudo T, Motomura Y, Okuzaki D, Hasegawa T, Yokota T, Kikuta J, Ao T, Mizuno H, Matsui T, Motooka D, Yoshizawa R, Nagasawa T, Kanakura Y, Moro K, Ishii M. Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions. J Exp Med. 2021 218:e20200817. 
  • Morimoto A, *Kikuta J, Nishikawa K, Sudo T, Uenaka M, Furuya M, Hasegawa T, Hashimoto K, Tsukazaki H, Seno S, Nakamura A, Okuzaki D, Sugihara F, Ninomiya A, Yoshimura T, Takao-Kawabata R, Matsuda H, *Ishii M. SLPI is a critical mediator that controls PTH-induced bone formation. Nat Commun. 2021 12:2136. (*Co-corresponding author)
  • Takeuchi S, Tsuchiya A, Iwasawa T, Nojiri S, Watanabe T, Ogawa M, Yoshida T, Fujiki K, Koui Y, Kido T, Yoshioka Y, Fujita M, Kikuta J, Itoh T, Takamura M, Shirahige K, Ishii M, Ochiya T, Miyajima A, Terai S.  Small extracellular vesicles derived from interferon-γ pre-conditioned mesenchymal stromal cells effectively treat liver fibrosis. NPJ Regen Med. 2021 6(1):19. 
  • Mimoto F, Tatsumi K, Shimizu S, Kadono S, Haraya K, Nagayasu M, Suzuki Y, Fujii E, Masaki Kamimura M, Hayasaka A, Kawauchi H, Ohara K, Matsushita M, Baba T, Susumu H, Sakashita T, Muraoka T, Aso K, Katada H, Tanaka E, Nakagawa K, Hasegawa M, Ayabe M, Yamamoto T, Tanba S, Ishiguro T, Kamikawa T, Nambu T, Kibayashi T, Azuma Y, Tomii Y, Kato A, Ozeki K, Murao N, Endo M, Kikuta J, Kamata-Sakurai M, Ishii M, Hattori K, Igawa T. Exploitation of elevated extracellular ATP to specifically direct antibody to tumor microenvironment. Cell Rep. 2020 33:108542. 
  • Hashimoto R, Minoshima M, Kikuta J, Yari S, Bull SD, Ishii M, Kikuchi K. An acid activatable fluorescence probe for imaging osteocytic bone resorption activity in deep bone cavities. Angew Chem Int Ed Engl. 2020 59:20996-21000. 
  • Ao T, *Kikuta J, Sudo T, Uchida Y, Kobayashi K, *Ishii M. Local sympathetic neurons promote neutrophil egress from the bone marrow at the onset of acute inflammation. Int Immunol. 2020 32:727-736. (*Co-corresponding author)
  • Matsui T, Tamoto R, Iwasa A, Mimura M, Taniguchi S, Hasegawa T, Sudo T, Mizuno H, Kikuta J, Onoyama I, Okugawa K, Shiomi M, Matsuzaki S, Morii E, Kimura T, Kato K, Kiyota Y, Ishii M. Nonlinear optics with near-infrared excitation enable real-time quantitative diagnosis of human cervical cancers. Cancer Res. 2020 80:3745-3754. 
  • Hasegawa T, Kikuta J, Sudo T, Yamashita E, Seno S, Takeuchi T, Ishii M. Development of real-time intravital imaging system of the synovial tissue reveals the dynamics of CTLA-4 Ig in vivo. Sci Rep. 2020 10:13480. 
  • Morimatsu M, Yamashita E, Seno S, Sudo T, Kikuta J, Mizuno H, Okuzaki D, Motooka D, Ishii M. Migration arrest of chemoresistant leukemia cells mediated by MRTF-SRF pathway. Inflam Regen. 2020 40:15. 
  • Nishizawa S, *Kikuta J, Seno S, Kajiki M, Tsujita R, Mizuno H, Sudo T, Ao T, Matsuda H, *Ishii M. Thrombomodulin induces anti-inflammatory effects by inhibiting the rolling adhesion of leukocytes in vivo. J Pharmacol Sci. 2020 143:17-22. (*Co-corresponding author)
  • Hashimoto K, Kaito T, Furuya M, Seno S, Okuzaki D, Kikuta J, Tsukazaki H, Matsuda H, Yoshikawa H, Ishii M. In vivo dynamic analysis of BMP-2-induced ectopic bone formation. Sci Rep. 2020 10:4751.
  • Hasegawa T, Kikuta J, Sudo T, Matsuura Y, Simmons S, Ebina K, Hirao M, Okuzaki D, Yoshida Y, Hirao A, Kalinichenko, VV, Yamaoka K, Takeuchi T, Ishii M. Identification of a novel arthritis–associated osteoclast precursor macrophage regulated by FoxM1. Nat Immunol. 2019 20:1631-1643. 
  • Kojima Y, Tsuchiya A, Ogawa M, Nojiri S, Takeuchi S, Watanabe T, Nakajima K, Hara Y, Yamashita J, Kikuta J, Takamura M, Ishii M, Terai S. Mesenchymal stem cells cultured under hypoxic conditions had a greater therapeutic effect on mice with liver cirrhosis compared to those cultured under normal oxygen conditions. Regen Ther. 2019 11:269-281. 
  • Minoshima M, Kikuta J, Omori Y, Seno S, Suehara R, Maeda H, Matsuda H, Ishii M, Kikuchi K.　In vivo multicolor imaging with fluorescent probes revealed the dynamics and function of osteoclast proton pumps. ACS Cent Sci. 2019 5:1059-66. 
  • Watanabe Y, Tsuchiya A, Seino S, Kawata Y, Kojima Y, Ikarashi S, Lewis PJS, Lu W-Y, Kikuta J, Kawai H, Yamagiwa S, Forbes SJ, Ishii M, Terai S. Mesenchymal stem cells and induced bone marrow-derived macrophages synergistically improve liver fibrosis in mice. Stem Cells Transl Med. 2019 8:271-284. 
  • Morita N, Umemoto E, Fujita S, Hayashi A, Kikuta J, Kimura I, Haneda T, Imai T, Inoue A, Mimuro H, Maeda Y, Kayama H, Okumura R, Aoki J, Okada N, Kida T, Ishii M, Nabeshima R, Takeda K. GPR31-dependent dendrite protrusion of intestinal CX3CR1+ cells by bacterial metabolites. Nature. 2019 566:110-114. 
  • Kikuta J, Shirazaki M, Sudo T, Mizuno H, Morimoto A, Suehara R, Minoshima M, Kikuchi K, Ishii M. Dynamic analyses of the short term effects of different bisphosphonates using intravital two photon microscopy. JBMR Plus. 2018 2:362-366.
  • Matsuura R, Miyagawa S, Fukushima S, Goto T, Harada A, Shimozaki Y, Yamaki K, Sanami S, Kikuta J, Ishii M, Sawa Y. Intravital imaging with two-photon microscopy reveals cellular dynamics in the ischeamia-reperfused rat heart. Sci Rep. 2018 8:15991. 
  • Das P, Veazey KJ, Van HT, Kaushik S, Lin K, Lu Y, Ishii M, Kikuta J, Ge K, Nussenzweig A, Santos MA. Histone methylation regulator PTIP is required to maintain normal and leukemic bone marrow niches. Proc Natl Acad Sci USA. 2018 115:E10137-E10146. 
  • Nagatake T, Shiogama Y, Inoue A, Kikuta J, Honda T, Tiwari P, Yanagisawa A, Isobe Y, Matsumoto N, Shimojou M, Morimoto S, Suzuki H, Hirata S, Steneberg P, Edlund H, Aoki J, Arita M, Kiyono H, Yasutomi Y, Ishii M, Kabashima K, Kunisawa J. The 17,18-epoxyeicosatetraenoic acid-G protein-coupled receptor 40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques. J Allergy Clin Immunol. 2018 142:470-484. 
  • Matsuura Y, *Kikuta J, Kishi Y, Hasegawa T, Okuzaki D, Hirano T, Minoshima M, Kikuchi K, Kumanogoh A, *Ishii M. In vivo visualisation of different modes of action of biological DMARDs inhibiting osteoclastic bone resorption. Ann Rheum Dis. 2018 77:1219-1225. (*Co-corresponding author)
  • Inaki M, Hatori R, Kikuta J, Ishii M, Matsuno K, Honda H. Chiral cell sliding drives left-right asymmetric organ twisting. Elife. 2018 7:e32506. 
  • Yamaga K, Murota H, Tamura A, Miyata H, Ohmi M, Kikuta J, Ishii M, Tsukita S, Katayama I. Claudin-3 loss causes leakage of sweat from the sweat gland to contribute to the pathogenesis of atopic dermatitis. J Invest Dermatol. 2018 138:1279-1287.
  • Ueda Y, Ishiwata T, Shinji S, Arai T, Matsuda Y, Aida J, Sugimoto N, Okazaki T, Kikuta J, Ishii M, Sato M. In vivo imaging of T cell lymphoma infiltration process at the colon. Sci Rep. 2018 8:3978. 
  • Furuya M, Kikuta J, Fujimori S, Seno S, Maeda H, Shirazaki M, Uenaka M, Mizuno H, Iwamoto Y, Morimoto A, Hashimoto K, Ito T, Isogai Y, Kashii M, Kaito T, Ohba S, Chung Ui, Lichtler AC, Kikuchi K, Matsuda H, Yoshikawa H, Ishii M. Direct cell-cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo. Nat Commun. 2018 9:300. 
  • Shigeta H, Mashita T, Kikuta J, Seno S, Takemura H, Ishii M, Matsuda H. Bone marrow cavity segmentation using graph-cuts with wavelet-based texture feature.　J Bioinform Comput Biol. 2017 15:1740004. 
  • Matsui T, Mizuno H, Sudo T, Kikuta J, Haraguchi N, Ikeda J, Mizushima T, Yamamoto H, Morii E, Mori M, Ishii M. Non-labeling multiphoton excitation microscopy as a novel diagnostic tool for discriminating normal tissue and colorectal cancer lesions. Sci Rep. 2017 7:6959. 
  • Kon S, Ishibashi K, Katoh H, Kitamoto S, Kajita M, Ishikawa S, Yamauchi H, Yako Y, Kamasaki T, Matsumoto T, Watanabe H, Egami R, Sasaki A, Nishikawa A, Kameda I, Maruyama T, Sasaki Y, Enoki R, Honma S, Imamura H, Oshima M, Soga T, Miyazaki J, Sato T, Duchen M, Shirai T, Tanaka S, Narumi R, Morita T, Nam J, Onodera Y, Yoshioka S, Kikuta J, Ishii M, Imajo M, Nishida E, Fujioka Y, Ohba Y, Fujita Y. Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes. Nat Cell Biol. 2017 19:530-541. 
  • Miyachi Y, Tsuchiya K, Komiya C, Shiba K, Shimazu N, Yamaguchi S, Deushi M, Osaka M, Inoue K, Sato Y, Matsumoto S, Kikuta J, Wake K, Yoshida M, Ishii M, Ogawa Y. Roles for cell-cell adhesion and contact in obesity-induced hepatic myeloid cell accumulation and glucose intolerance. Cell Rep. 2017 18:2766-2779. 
  • Lim BC, Matsumoto S, Yamamoto H, Mizuno H, Kikuta J, Ishii M, Kikuchi A. Prickle1 promotes focal adhesion disassembly in cooperation with CLASP-LL5β complex in migrating cells. J Cell Sci. 2016 129:3115-3129. 
  • Otani K, Naito Y, Sakaguchi Y, Seo Y, Takahashi Y, Kikuta J, Ogawa K, Ishii M. Cell-cycle-controlled radiation therapy was effective for treating a murine malignant melanoma cell line in vitro and in vivo. Sci Rep. 2016 6:30689. 
  • Maeda H, Kowada T, Kikuta J, Furuya M, Shirazaki M, Mizukami S, Ishii M, Kikuchi K. Real-time intravital imaging of pH variation associated with osteoclast activity. Nat Chem Biol. 2016 12:579-585. 
  • Kojima S, Inoue T, Kikuta J, Furuya M, Koga A, Fujimoto T, Ueta M, Kinoshita S, Ishii M, Tanihara H. Visualization of intravital immune cell dynamics after conjunctival surgery using multiphoton microscopy. Invest Ophthalmol Vis Sci. 2016 57:1207-1212.
  • Ueta M, Koga A, Kikuta J, Yamada K, Kojima S, Ishii M, Kinoshita S. Intravital imaging of the cellular dynamics of LysM-positive cells in a murine corneal suture model. Br J Ophthalmol. 2016 100:432-435. 
  • Takeda A, Kobayashi D, Aoi K, Sasaki N, Sugiura Y, Igarashi H, Tohya K, Inoue A, Hata E, Akahoshi N, Hayasaka H, Kikuta J, Scandella E, Ludewig B, Ishii S, Aoki J, Suematsu M, Ishii M, Takeda K, Jalkanen S, Miyasaka M, Umemoto E. Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility. Elife. 2016 5:e10561. 
  • Yoshikawa S, Usami T, Kikuta J, Ishii M, Sasano T, Sugiyama K, Furukawa T, Nakasho E, Takayanagi H, Tedder TF, Karasuyama H, Miyawaki A, Adachi T. Intravital imaging of Ca2+ signals in lymphocytes of Ca2+ biosensor transgenic mice: indication of autoimmune diseases before the pathological onset. Sci Rep. 2016 6:18738.
  • Onodera T, Fukuhara A, Jang MH, Shin J, Aoi K, Kikuta J, Otsuki M, Ishii M, Shimomura I. Adipose tissue macrophages induce PPARγ-high FOXP3+ regulatory T cells. Sci Rep. 2015 5:16801. 
  • Nevius E, Pinho F, Dhodapkar M, Jin H, Nadrah K, Horowitz MC, Kikuta J, Ishii M, Pereira JP. Oxysterols and EBI2 promote osteoclast precursor migration to bone surfaces and regulate bone mass homeostasis. J Exp Med. 2015 212:1931-1946. 
  • Sano H, Kikuta J, Furuya M, Kondo N, Endo N, Ishii M. Intravital bone imaging by two-photon excitation microscopy to identify osteocytic osteolysis in vivo. Bone. 2015 4:134-139. 
  • Sekimoto R, Fukuda S, Maeda N, Tsushima Y, Matsuda K, Mori T, Nakatsuji H, Nishizawa H, Kishida K, Kikuta J, Maijima Y, Funahashi T, Ishii M, Shimomura I. Visualized macrophage dynamics and significance of S100A8 in obese fat. Proc Natl Acad Sci USA. 2015 112:E2058-E2066. 
  • Naito A, Yamamoto H, Kagawa Y, Naito Y, Okuzaki D, Otani K, Iwamoto Y, Maeda S, Kikuta J, Nishikawa K, Uemura M, Nishimura J, Hata T, Takemasa I, Mizushima T, Ishii H, Doki Y, Mori M, Ishii M. RFPL4A increases the G1 population and decreases sensitivity to chemotherapy in human colorectal cancer cells. J Biol Chem. 2015 290:6326-6337. 
  • Iinuma S, Aikawa E, Tamai K, Fujita R, Kikuchi Y, Chino T, Kikuta J, McGrath J, Uitto J, Ishii M, Iizuka H, Kaneda Y. Transplanted bone marrow-derived circulating PDGFRα+ cells restore type VII collagen in recessive dystrophic epidermolysis bullosa mouse skin graft. J Immunol. 2015 194:1996-2003. 
  • Maeda S, Wada H, Naito Y, Nagano H, Simmons S, Kagawa Y, Naito A, Kikuta J, Ishii T, Tomimaru Y, Hama N, Kawamoto K, Kobayashi S, Eguchi H, Umeshita K, Ishii H, Doki Y, Mori M, Ishii M. Interferon-α acts on the S/G2/M phases to induce apoptosis in the G1 phase of an IFNAR2-expressing hepatocellular carcinoma cell line. J Biol Chem. 2014 289:23786-23795. 
  • Hatori R, Ando T, Sasamura T, Nakazawa N, Nakamura M, Taniguchi K, Hozumi S, Kikuta J, Ishii M, Matsuno K. Left-right asymmetry is formed in individual cells by intrinsic cell chirality. Mech Dev. 2014 133:146-162. 
  • Kajita M, Sugimura K, Ohoka A, Burden J, Suganuma H, Ikegawa M, Shimada T, Kitamura T, Shindoh M, Ishikawa S, Yamamoto S, Saitoh S, Yako Y, Takahashi R, Okajima T, Kikuta J, Maijima Y, Ishii M, Tada M, Fujita Y. Filamin acts as a key regulator in epithelial defence against transformed cells. Nat Commun. 2014 5:4428. 
  • Matsui S, Murota H, Ono E, Kikuta J, Ishii M, Katayama I. Olopatadine hydrochloride restores histamine-induced impaired sweating. J Dermatol Sci. 2014 74: 260-261. 
  • Masahata K, Umemoto E, Kayama H, Kotani M, Nakamura S, Kurakawa T, Kikuta J, Gotoh K, Motooka D, Sato S, Higuchi T, Baba Y, Kurosaki T, Kinoshita M, Shimada Y, Kimura T, Okumura R, Takeda A, Tajima M, Yoshie O, Fukuzawa M, Kiyono H, Fagarasan S, Iida T, Ishii M, Takeda K. Generation of colonic IgA-secreting cells in the caecal patch. Nat Commun. 2014 5:3704. 
  • David M, Machuca-Gayet I, Kikuta J, Ottewell P, Mima F, Leblanc R, Bonnelye E, Ribeiro J, Holen I, Lopez Vales R, Jurdic P, Chun J, Clézardin P, Ishii M, Peyruchaud O. Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity. J Biol Chem. 2014 289:6551-6564. 
  • Matsui S, Murota H, Ono E, Kikuta J, Ishii M, Katayama I. Dynamic analysis of histamine-mediated attenuation of acetylcholine-induced sweating via GSK3β activation. J Invest Dermatol. 2014 134:326-334. 
  • Kagawa Y, Matsumoto S, Kamioka Y, Mimori M, Naito Y, Ishii T, Okuzaki D, Nishida N, Maeda S, Naito A, Kikuta J, Nishikawa K, Nishimura J, Haraguchi N, Takemasa I, Mizushima T, Ikeda M, Yamamoto H, Sekimoto M, Ishii H, Doki Y, Matsuda M, Kikuchi A, Mori M, Ishii M. Cell cycle-dependent Rho GTPase activity dynamically regulates cancer cell motility and invasion in vivo. PLoS One. 2013 8:e83629. 
  • Ueno M, Fujita Y, Tanaka T, Nakamura Y, Kikuta J, Ishii M, Yamashita T. Layer V cortical neurons require microglial support for survival during postnatal development. Nat Neurosci. 2013 16:543-551. 
  • Kikuta J, Kawamura S, Okiji F, Shirazaki M, Sakai S, Saito H, Ishii M. Sphingosine-1- phosphate-mediated osteoclast precursor monocyte migration is a critical point of control in antibone-resorptive action of active vitamin D. Proc Natl Acad Sci USA. 2013 110:7009-7013. 
  • Kikuta J, Wada Y, Kowada T, Wang Z, Sun-Wada G-H, Nishiyama I, Mizukami S, Maiya N, Yasuda H, Kumanogoh A, Kikuchi K, Germain RN, Ishii M. Dynamic visualization of RANKL and Th17-mediated osteoclast function. J Clin Invest. 2013 123:866-873. 
  • Kotani M, Kikuta J, Klauschen F, Chino T, Kobayashi Y, Yasuda H, Tamai K, Miyawaki A, Kanagawa O, Tomura M, Ishii M. Systemic circulation and bone recruitment of osteoclast precursors tracked by using fluorescent imaging techniques. J Immunol. 2013 190:605-612. 
  • Kowada T, Kikuta J, Kubo A, Ishii M, Maeda H, Mizukami S, Kikuchi K. In vivo fluorescence imaging of bone-resorbing osteoclasts. J Am Chem Soc. 2011 33:17772-17776. 
  • Kikuta J, Iwai K, Saeki Y, Ishii M. S1P-targeted therapy for elderly rheumatoid arthritis patients with osteoporosis. Rheumatol Int. 2011 31:967-969. 
  • Ishii M, Kikuta J, Shimazu Y, Meier-Schellersheim M, Germain RN. Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo. J Exp Med. 2010 207:2793-2798. 
  • Kikuta J, Ishii M, Kishimoto K, Kurachi Y. Carvedilol blocks cardiac KATP and KG but not IK1 channels by acting at the bundle-crossing regions. Eur J Pharmacol. 2006 529:47-54. 
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論文（総説）

2023年度

  • 1.    Sudo T, Yamashita E, Kikuta J, Ishii M, Protocol for live imaging of transferred mouse bone marrow cells by two-photon microscopy. STAR Protoc. 2023 4(4):102654.
 
 --------アコーディオンパーツを削除する際は、この一行上の空白行から[アコーディオン終了]まで全てを選択し削除してください--------
2022年度以前
  • Agemura T, Hasegawa T, Yari S, Kikuta J, Ishii M. Arthritis-associated osteoclastogenic macrophage, AtoM, as a key player in pathological bone erosion. Inflamm Regen. 2022 42:17.
  • Agemura T, Hasegawa T, Yari S, Kikuta J, Ishii M. Arthritis-associated osteoclastogenic macrophages (AtoMs) participate in pathological bone erosion in rheumatoid arthritis. Immunol Med. 2022 45:22-26.
  • Ao T, Kikuta J, Ishii M. The effects of vitamin D on immune system and inflammatory diseases. Biomolecules. 2021 11:1624.
  • Hasegawa T, Kikuta J, Ishii M. Imaging of bone and joints in vivo: pathological osteoclastogenesis in arthritis. Int Immunol. 2021 33:679-686.
  • Hashimoto K, Kaito T, Kikuta J, Ishii M. Intravital imaging of orthotopic and ectopic bone. Inflamm Regen. 2020 40:26.
  • Morimoto A, Kikuta J, Ishii M. Intravital multiphoton microscopy as a novel tool in the field of immunopharmacology. Pharmacol Ther. 2020 206:107429.
  • Hasegawa T, Kikuta J, Ishii M. Imaging the bone-immune cell interaction in bone destruction. Frontiers Immunol. 2019 10:596.
  • Mizuno H, Kikuta J, Ishii M. In vivo live imaging of bone cells. Histochem Cell Biol. 2018 149:417-422.
  • Kikuta J, Ishii M. Bone imaging: Osteoclast and osteoblast dynamics. Methods Mol Biol. 2018 1763:1-9.
  • Matsumoto S, Kikuta J, Ishii M. Intravital imaging of liver cell dynamics. Methods Mol Biol. 2018 1763:137-143.
  • Matsuura R, Miyagawa S, Kikuta J, Ishii M, Sawa Y. Intravital imaging of the heart at the cellular level using two-photon microscopy. Methods Mol Biol. 2018 1763:145-151.
  • Murota H, Matsui S, Ono E, Kijima A, Kikuta J, Ishii M, Katayama I. Sweat, the driving force behind normal skin: an emerging perspective on functional biology and regulatory mechanisms. J Dermatol Sci. 2015 77:3-10.
  • Kikuta J, Ishii M. Intravital multiphoton microscopy for dissecting cellular dynamics in arthritic inflammation and bone destruction. Methods Mol Biol. 2014 1142:1-10.
  • Ishii M, Fujimori S, Kaneko T, Kikuta J. Dynamic live imaging of bone: opening a new era with 'bone histodynametry'. J Bone Miner Metab. 2013 31:507-511.
  • Kikuta J, Ishii M. Osteoclast migration, differentiation, and function: novel therapeutic targets for rheumatic diseases. Rheumatology. 2013 52:226-234.
  • Ishii M, Kikuta J. Sphingosine-1-phosphate signaling controlling osteoclasts and bone homeostasis. Biochim Biophys Acta. 2013 1831(1): 223–227.
  • Kikuta J, Ishii M. Recent advances in intravital imaging of dynamic biological systems. J Pharmacol Sci. 2012 119:193-197.
  • Ishii T, Kawamura S, Nishiyama I, Kikuta J, Ishii M. Use of intravital microscopy and in vitro chemotaxis assays to study the roles of sphingosine-1-phosphate in bone homeostasis. Methods Mol Biol, 2012 874:129-139.
  • Ishii T, Shimazu Y, Nishiyama I, Kikuta J, Ishii M. The role of sphingosine 1-phosphate in migration of osteoclast precursors; an application of intravital two-photon microscopy. Mol Cells. 2011 31(5): 399-403.
  • Ishii T, Kikuta J, Kubo A, Ishii M. Control of osteoclast precursor migration: A novel point of control for osteoclastogenesis and bone homeostasis. IBMS BoneKey. 2010 7: 279-286.
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書籍・出版物

2024年度

  • 菊田順一. 概論―生体イメージングで生命機能を“観る”“解く”“識る”“操る”―新たな技術開発の挑戦と生命科学研究への応用. 実験医学42(19):2954-2960, 2024.


 

主な招待講演

2024年度

  • 菊田順一、生体イメージングで捉える骨代謝ダイナミクス、第97回日本内分泌学会学術集会総会、2024年
  • 菊田順一、生体イメージングで捉える骨髄血管透過性制御機構、第42回日本骨代謝学会学術集会、2024年
  • 菊田順一、生体イメージングによる線維症の解析、第45回日本炎症・再生医学会、2024年
  • 菊田順一、炎症性骨破壊の時空間的動態解析と新規治療法の開発、生体機能と創薬シンポジウム2024、2024年
  • 菊田順一、Spatio-temporal analysis of tissue remodeling dynamics by intravital imaging techniques、第97回日本生化学会大会、2024年
  • 菊田順一、⽣体イメージングで捉えるマクロファージの動態と機能、第47回日本分子生物学会年会、2024年
  • 菊田順一、生体イメージングで解き明かす骨髄血管透過性の制御メカニズム、第47回日本分子生物学会年会、2024年
  • 菊田順一、Regulatory mechanism of macrophage dynamics in tissue repair and fibrosis、日独免疫ワークショップ、2024年
 

2023年度

  • 菊田順一、石井優、生体イメージングを活用した再生医療研究、第23回日本再生医療学会総会、2024年
  • 菊田順一、石井優、生体イメージングによる分子標的治療薬のin vivo薬理作用の解明、第97回日本薬理学会年会、2023年
  • 菊田順一、石井優、生体二光子励起イメージングで解き明かすバイオミネラリゼーション、第52回結晶成長国内会議、2023年
  • Kikuta J. Intravital imaging of in vivo pharmacological actions of drugs on the immune system. The 9th China-Japan Joint Meeting of Basic and ClinicalPharmacology, 2023.
  • 菊田順一、石井優、生体イメージングで捉える炎症性骨破壊・線維化の動的実態、第44回日本炎症・再生医学会、2023年
  • 菊田順一、石井優、生体イメージングによる炎症性破骨細胞の動態・機能解析、第67回日本リウマチ学会総会学術集会、2023年
 
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2022年度以前
  • 菊田順一、石井優、生体イメージング技術による免疫疾患治療薬のin vivo薬理作用の解明、第96回日本薬理学会年会、2022年
  • 菊田順一、石井優、生体多光子励起イメージングによる免疫疾患の病態解明、第50回日本臨床免疫学会総会、2022年
  • 菊田順一、石井優、ゼロから始める生体イメージング研究～病態解明と新たな治療を目指して～、第31回日本リウマチ学会近畿支部学術集会、2022年
  • Junichi Kikuta, Masaru Ishii. Intravital imaging technology dissecting cellular dynamics in inflammation and bone destruction in vivo. 23rd Asia-Pacific League of Associations for Rheumatology Congress, 2021.
  • 菊田順一、石井優、生体イメージングと骨代謝、第39回日本骨代謝学会学術集会、2021年
  • 菊田順一、石井優、骨免疫イメージングアップデート、第38回日本骨代謝学会学術集会、2020年
  • 菊田順一、石井優、骨破壊・免疫炎症の生体イメージング解析、第50回日本腎臓学会東部学術大会、2020年
  • 菊田順一、石井優、骨破壊・免疫炎症の生体イメージング、第41回日本炎症・再生医学会、2020年
  • Junichi Kikuta, Masaru Ishii. Intravital imaging technology dissecting cellular dynamics in inflammation and cancers in vivo. The 15th US-Japan Symposium on Drug Delivery Systems, 2019.
  • Junichi Kikuta, Masaru Ishii. In vivo visualization of immune cell dynamics and drug actions in rheumatic diseases. The 8th East Asian Group of Rheumatology, 2019.
  • 菊田順一、石井優、生体試料を見る、第37回日本骨代謝学会学術集会、2019年
  • 菊田順一、石井優、生体イメージングによる疾患・創薬研究、第63回日本リウマチ学会総会・学術集会、2019年
  • 菊田順一、生体イメージングによる病態評価、第33回日本整形外科学会基礎学術集会、2018年
  • 菊田順一、生体イメージングでみる骨代謝ダイナミクス、第91回日本生化学会大会、2018年
  • 菊田順一、骨・関節の蛍光生体イメージングによる骨破壊の病態解明、第62回日本リウマチ学会総会・学術集会、2018年
  • 菊田順一、骨・関節炎症の生体イメージング、第45回日本臨床免疫学会総会、2017年
  • 菊田順一、生体イメージングで解く骨代謝調節機構、第59回歯科基礎医学会学術大会、2017年
  • 菊田順一、骨・関節の生体二光子励起イメージング、第3回日本骨免疫学会、2017年
  • 菊田順一、二光子励起顕微鏡で観る骨組織内の細胞動態ネットワーク、第37回日本骨形態計測学会、2017年
  • 菊田順一、蛍光生体イメージングで解く骨髄・免疫細胞の動的ネットワーク、第122回日本解剖学会総会・学術集会、2017年
  • 菊田順一、蛍光生体イメージングで解く破骨細胞・骨芽細胞のクロストーク、第31回日本整形外科学会基礎学術集会、2016年
  • 菊田順一、骨関節破壊のイメージング、第44回日本臨床免疫学会総会、2016年
  • 菊田順一、蛍光生体イメージングで解く免疫・血液細胞の動的ネットワーク、第26回日本サイトメトリー学会、2016年
  • 菊田順一、骨免疫イメージング、第34回日本骨代謝学会学術集会、2016年
  • 菊田順一、生体二光子励起イメージングによる骨髄血管透過性の制御機構解明とDDS研究への応用、第32回日本ＤＤＳ学会学術集会、2016年
  • 菊田順一、骨の炎症・再生の生体イメージング、第37回日本炎症・再生医学会、2016年
  • 菊田順一、破骨細胞動態イメージング、第60回日本リウマチ学会総会・学術集会、2016年
  • 菊田順一、蛍光生体イメージングでみる骨の炎症・再生、第15回日本再生医療学会総会、2016年
  • 菊田順一、In vivoバイオイメージングを用いた骨粗鬆症治療薬の薬効評価、第24回硬組織再生生物学会学術大会・総会、2015年
  • 菊田順一、丸ごとのイメージング〜免疫細胞の動く世界の解析〜、第49回日本実験動物技術者協会総会、2015年
  • 菊田順一、生体二光子励起イメージングによる骨代謝ダイナミクスの動的解析、第87回日本生化学会大会、2014年
  • 菊田順一、生体多光子励起イメージングによる生きた細胞動態の解析、第33回日本医用画像工学会、2014年
  • 菊田順一、石井優、2光子励起顕微鏡を駆使した骨髄イメージング、第32回日本骨代謝学会学術集会、2014年
  • 菊田順一、生体多光子励起イメージングによる骨髄・免疫細胞の動態解析、第37回日本リンパ学会総会、2013年
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