竹縄 忠臣 (薬学博士）
略歴
1967年 京都大学薬学部 卒
1973年 筑波大学基礎医学系薬理 講師
1982年 東京大学医学部生化学 助教授
1986年 東京都老人総合研究所 生体情報 部長
1992年 東京大学医科学研究所 腫瘍分子医学 教授
2007年 神戸大学医学系研究科 脂質生化学 特命教授
2007年 東京大学 名誉教授
2012年 神戸大学大学院医学研究科 質量分析総合センター長
業績
| 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 |
2012
1. Role of Phosphatidylinositol 3,4,5-trisphosphate (PIP3) 5-phosphatase, skeletal muscle and kidney enriched inositol polyphosphate phosphatase (SKIP) in myoblast differentiation.
Ijuin T, Takenawa T.
J Biol Chem. 2012 Jul 19. PMID: 22815484
2. A novel serum metabolomics-based diagnostic approach for colorectal cancer.
Nishiumi S, Kobayashi T, Ikeda A, Yoshie T, Kibi M, Izumi Y, Okuno T, Hayashi N, Kawano S, Takenawa T, Azuma T, Yoshida M.
PLoS One. 2012;7(7):e40459. PMID: 22792336
3. Regulation of Insulin Signaling by the Phosphatidylinositol 3,4,5-Triphosphate Phosphatase SKIP through the Scaffolding Function of Pak1.
Ijuin T, Takenawa T.
Mol Cell Biol. 2012 Sep;32(17):3570-84. PMID: 22751929
4. The inositol 5-phosphatase SHIP2 is an effector of RhoA and is involved in cell polarity and migration.
Kato K, Yazawa T, Taki K, Mori K, Wang S, Nishioka T, Hamaguchi T, Itoh T, Takenawa T, Kataoka C, Matsuura Y, Amano M, Murohara T, Kaibuchi K.
Mol Biol Cell. 2012 Jul;23(13):2593-604. PMID: 22593208
5. ARAP1 regulates the ring size of circular dorsal ruffles through Arf1 and Arf5.
Hasegawa J, Tsujita K, Takenawa T, Itoh T.
Mol Biol Cell. 2012 Jul;23(13):2481-9. PMID: 22573888
6. Quantification and visualization of phosphoinositides by quantum dot-labeled specific binding-domain probes.
Irino Y, Tokuda E, Hasegawa J, Itoh T, Takenawa T.
J Lipid Res. 2012 Apr;53(4):810-9. PMID: 22308508
7. Regulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP).
Ijuin T, Takenawa T.
J Biol Chem. 2012 Mar 2;287(10):6991-9. PMID: 22247557
8. Diagnosis of gastroenterological diseases by metabolome analysis using gas chromatography-mass spectrometry.
Yoshida M, Hatano N, Nishiumi S, Irino Y, Izumi Y, Takenawa T, Azuma T.
J Gastroenterol. 2012 Jan;47(1):9-20. Review. PMID: 22041921
9. Serum metabolomics as a novel diagnostic approach for gastrointestinal cancer.
Ikeda A, Nishiumi S, Shinohara M, Yoshie T, Hatano N, Okuno T, Bamba T, Fukusaki E, Takenawa T, Azuma T, Yoshida M.
Biomed Chromatogr. 2012 May;26(5):548-58. PMID: 2177398
2011
10. Serum fatty acid profiling of colorectal cancer by gas chromatography/mass spectrometry.
Kondo Y, Nishiumi S, Shinohara M, Hatano N, Ikeda A, Yoshie T, Kobayashi T, Shiomi Y, Irino Y, Takenawa T, Azuma T, Yoshida M.
Biomark Med. 2011 Aug;5(4):451-60. PMID: 21861667
11. Characterization of the EFC/F-BAR domain protein, FCHO2.
Uezu A, Umeda K, Tsujita K, Suetsugu S, Takenawa T, Nakanishi H.
Genes Cells. 2011 Aug;16(8):868-78. PMID: 21762413
12. Involvement of PRIP, phospholipase C-related, but catalytically inactive protein, in bone formation.
Tsutsumi K, Matsuda M, Kotani M, Mizokami A, Murakami A, Takahashi I, Terada Y, Kanematsu T, Fukami K, Takenawa T, Jimi E, Hirata M.
J Biol Chem. 2011 Sep 2;286(35):31032-42. PMID: 21757756
13. SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain.
Hasegawa J, Tokuda E, Tenno T, Tsujita K, Sawai H, Hiroaki H, Takenawa T, Itoh T.
J Cell Biol. 2011 May 30;193(5):901-16. PMID: 21624956
14. Neural Wiskott-Aldrich syndrome protein is required for accurate chromosome congression and segregation.
Park SJ, Takenawa T.
Mol Cells. 2011 Jun;31(6):515-21. PMID: 21533546
15. GC/MS-based profiling of amino acids and TCA cycle-related molecules in ulcerative colitis.
Ooi M, Nishiumi S, Yoshie T, Shiomi Y, Kohashi M, Fukunaga K, Nakamura S, Matsumoto T, Hatano N, Shinohara M, Irino Y, Takenawa T, Azuma T, Yoshida M.
Inflamm Res. 2011 Sep;60(9):831-40. PMID: 21523508
16. Regulation of IGF-1/PI3K/Akt signalling by the phosphoinositide phosphatase pharbin.
Wang F, Ijuin T, Itoh T, Takenawa T.
J Biochem. 2011 Jul;150(1):83-93. PMID: 21436142
17. A metabolomic approach to lung cancer.
Hori S, Nishiumi S, Kobayashi K, Shinohara M, Hatakeyama Y, Kotani Y, Hatano N, Maniwa Y, Nishio W, Bamba T, Fukusaki E, Azuma T, Takenawa T, Nishimura Y, Yoshida M.
Lung Cancer. 2011 Nov;74(2):284-92. PMID: 21411176
2010
18. Phosphoinositides regulate clathrin-dependent endocytosis at the tip of pollen tubes in Arabidopsis and tobacco.
Zhao Y, Yan A, Feijó JA, Furutani M, Takenawa T, Hwang I, Fu Y, Yang Z.
Plant Cell. 2010 Dec;22(12):4031-44. PMID: 21189293
19. Nebulin and N-WASP cooperate to cause IGF-1-induced sarcomeric actin filament formation.
Takano K, Watanabe-Takano H, Suetsugu S, Kurita S, Tsujita K, Kimura S, Karatsu T, Takenawa T, Endo T.
Science. 2010 Dec 10;330(6010):1536-40. PMID: 21148390
20. WASP and WAVE family proteins: friends or foes in cancer invasion?
Kurisu S, Takenawa T.
Cancer Sci. 2010 Oct;101(10):2093-104. Review. PMID: 20707804
21. Phosphoinositide-binding interface proteins involved in shaping cell membranes.
Takenawa T.
Proc Jpn Acad Ser B Phys Biol Sci. 2010;86(5):509-23. Review. PMID: 20467216
22. The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death.
Sasaki J, Kofuji S, Itoh R, Momiyama T, Takayama K, Murakami H, Chida S, Tsuya Y, Takasuga S, Eguchi S, Asanuma K, Horie Y, Miura K, Davies EM, Mitchell C, Yamazaki M, Hirai H, Takenawa T, Suzuki A, Sasaki T.
Nature. 2010 May 27;465(7297):497-501. PMID: 20463662
23. GABA(A) receptor subunit alteration-dependent diazepam insensitivity in the cerebellum of phospholipase C-related inactive protein knockout mice.
Mizokami A, Tanaka H, Ishibashi H, Umebayashi H, Fukami K, Takenawa T, Nakayama KI, Yokoyama T, Nabekura J, Kanematsu T, Hirata M.
J Neurochem. 2010 Jul;114(1):302-10. PMID: 20412381
24. Proteome of acidic phospholipid-binding proteins: spatial and temporal regulation of Coronin 1A by phosphoinositides.
Tsujita K, Itoh T, Kondo A, Oyama M, Kozuka-Hata H, Irino Y, Hasegawa J, Takenawa T.
J Biol Chem. 2010 Feb 26;285(9):6781-9. PMID: 20032464
25. Phospholipase C-related but catalytically inactive protein is required for insulin-induced cell surface expression of gamma-aminobutyric acid type A receptors.
Fujii M, Kanematsu T, Ishibashi H, Fukami K, Takenawa T, Nakayama KI, Moss SJ, Nabekura J, Hirata M.
J Biol Chem. 2010 Feb 12;285(7):4837-46. PMID: 19996098
26. Mutation of ARHGAP9 in patients with coronary spastic angina.
Takefuji M, Asano H, Mori K, Amano M, Kato K, Watanabe T, Morita Y, Katsumi A, Itoh T, Takenawa T, Hirashiki A, Izawa H, Nagata K, Hirayama H, Takatsu F, Naoe T, Yokota M, Kaibuchi K.
J Hum Genet. 2010 Jan;55(1):42-9. PMID: 19911011
2009
27. The tyrosine kinase Fer is a downstream target of the PLD-PA pathway that regulates cell migration.
Itoh T, Hasegawa J, Tsujita K, Kanaho Y, Takenawa T.
Sci Signal. 2009 Sep 8;2(87):ra52. PMID: 19738202
28. The WASP and WAVE family proteins.
Kurisu S, Takenawa T.
Genome Biol. 2009;10(6):226. Review. PMID: 19589182
29. Sac3 is an insulin-regulated phosphatidylinositol 3,5-bisphosphate phosphatase: gain in insulin responsiveness through Sac3 down-regulation in adipocytes.
Ikonomov OC, Sbrissa D, Ijuin T, Takenawa T, Shisheva A.
J Biol Chem. 2009 Sep 4;284(36):23961-71. PMID: 19578118
30. Involvement of phospholipase C-related inactive protein in the mouse reproductive system through the regulation of gonadotropin levels.
Matsuda M, Tsutsumi K, Kanematsu T, Fukami K, Terada Y, Takenawa T, Nakayama KI, Hirata M.
Biol Reprod. 2009 Oct;81(4):681-9. PMID: 19553601
31. A distinct pool of phosphatidylinositol 4,5-bisphosphate in caveolae revealed by a nanoscale labeling technique.
Fujita A, Cheng J, Tauchi-Sato K, Takenawa T, Fujimoto T.
Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9256-61. PMID: 19470488
32. Involvement of Rac and Rho signaling in cancer cell motility in 3D substrates.
Yamazaki D, Kurisu S, Takenawa T.
Oncogene. 2009 Apr 2;28(13):1570-83. PMID: 19234490
2008
33. Sequential signals toward podosome formation in NIH-src cells.
Oikawa T, Itoh T, Takenawa T.
J Cell Biol. 2008 Jul 14;182(1):157-69. PMID: 18606851
34. Increased insulin action in SKIP heterozygous knockout mice.
Ijuin T, Yu YE, Mizutani K, Pao A, Tateya S, Tamori Y, Bradley A, Takenawa T.
Mol Cell Biol. 2008 Sep;28(17):5184-95. PMID: 18573875
35. Involvement of the nectin-afadin complex in PDGF-induced cell survival.
Kanzaki N, Ogita H, Komura H, Ozaki M, Sakamoto Y, Majima T, Ijuin T, Takenawa T, Takai Y.
J Cell Sci. 2008 Jun 15;121(Pt 12):2008-17. PMID: 18505795
36. Actin -related protein 3 (Arp3) is mutated in proteinuric BUF/Mna rats.
Akiyama K, Morita H, Suetsugu S, Kuraba S, Numata Y, Yamamoto Y, Inui K, Ideura T, Wakisaka N, Nakano K, Oniki H, Takenawa T, Matsuyama M, Yoshimura A.
Mamm Genome. 2008 Jan;19(1):41-50. PMID: 18064521
37. Phospholipase C-delta1 is an essential molecule downstream of Foxn1, the gene responsible for the nude mutation, in normal hair development.
Nakamura Y, Ichinohe M, Hirata M, Matsuura H, Fujiwara T, Igarashi T, Nakahara M, Yamaguchi H, Yasugi S, Takenawa T, Fukami K.
FASEB J. 2008 Mar;22(3):841-9. PMID: 17938256
2007
38. Casein kinase 2-interacting protein-1, a novel Akt pleckstrin homology domain-interacting protein, down-regulates PI3K/Akt signaling and suppresses tumor growth in vivo.
Tokuda E, Fujita N, Oh-hara T, Sato S, Kurata A, Katayama R, Itoh T, Takenawa T, Miyazono K, Tsuruo T.
Cancer Res. 2007 Oct 15;67(20):9666-76. PMID: 17942896
39. The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery.
Eto K, Nishikii H, Ogaeri T, Suetsugu S, Kamiya A, Kobayashi T, Yamazaki D, Oda A, Takenawa T, Nakauchi H.
Blood. 2007 Nov 15;110(10):3637-47. PMID: 17664349
40. SGIP1alpha is an endocytic protein that directly interacts with phospholipids and Eps15.
Uezu A, Horiuchi A, Kanda K, Kikuchi N, Umeda K, Tsujita K, Suetsugu S, Araki N, Yamamoto H, Takenawa T, Nakanishi H.
J Biol Chem. 2007 Sep 7;282(36):26481-9. PMID: 17626015
41. Male-specific sterility caused by the loss of CR16.
Suetsugu S, Banzai Y, Kato M, Fukami K, Kataoka Y, Takai Y, Yoshida N, Takenawa T.
Genes Cells. 2007 Jun;12(6):721-33. PMID: 17573773
42. Synaptopodin protects against proteinuria by disrupting Cdc42:IRSp53:Mena signaling complexes in kidney podocytes.
Yanagida-Asanuma E, Asanuma K, Kim K, Donnelly M, Young Choi H, Hyung Chang J, Suetsugu S, Tomino Y, Takenawa T, Faul C, Mundel P.
Am J Pathol. 2007 Aug;171(2):415-27. PMID: 17569780
43. Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex.
Sbrissa D, Ikonomov OC, Fu Z, Ijuin T, Gruenberg J, Takenawa T, Shisheva A.
J Biol Chem. 2007 Aug 17;282(33):23878-91. PMID: 17556371
44. DA-Raf1, a competent intrinsic dominant-negative antagonist of the Ras-ERK pathway, is required for myogenic differentiation.
Yokoyama T, Takano K, Yoshida A, Katada F, Sun P, Takenawa T, Andoh T, Endo T.
J Cell Biol. 2007 Jun 4;177(5):781-93. PMID: 17535970
45. HSP90 cross-links branched actin filaments induced by N-WASP and the Arp2/3 complex.
Park SJ, Suetsugu S, Sagara H, Takenawa T.
Genes Cells. 2007 May;12(5):611-22. PMID: 17535252
46. Curved EFC/F-BAR-domain dimers are joined end to end into a filament for membrane invagination in endocytosis.
Shimada A, Niwa H, Tsujita K, Suetsugu S, Nitta K, Hanawa-Suetsugu K, Akasaka R, Nishino Y, Toyama M, Chen L, Liu ZJ, Wang BC, Yamamoto M, Terada T, Miyazawa A, Tanaka A, Sugano S, Shirouzu M, Nagayama K, Takenawa T, Yokoyama S.
Cell. 2007 May 18;129(4):761-72. PMID: 17512409
47. Molecular characterization of a novel RhoGAP, RRC-1 of the nematode Caenorhabditis elegans.
Delawary M, Nakazawa T, Tezuka T, Sawa M, Iino Y, Takenawa T, Yamamoto T.
Biochem Biophys Res Commun. 2007 Jun 1;357(2):377-82. PMID: 17434147
48. Phospholipase C-related inactive protein is involved in trafficking of gamma2 subunit-containing GABA(A) receptors to the cell surface.
Mizokami A, Kanematsu T, Ishibashi H, Yamaguchi T, Tanida I, Takenaka K, Nakayama KI, Fukami K, Takenawa T, Kominami E, Moss SJ, Yamamoto T, Nabekura J, Hirata M.
J Neurosci. 2007 Feb 14;27(7):1692-701. PMID: 17301177
49. Effect of WAVE2 phosphorylation on activation of the Arp2/3 complex.
Nakanishi O, Suetsugu S, Yamazaki D, Takenawa T.
J Biochem. 2007 Mar;141(3):319-25. PMID: 17202194
50. Stress-associated MAP kinase fills in the map of filamin-mediated neuronal migration.
Suetsugu S, Takenawa T.
Dev Cell. 2007 Jan;12(1):3-4. PMID: 17199035
51. The WASP-WAVE protein network: connecting the membrane to the cytoskeleton.
Takenawa T, Suetsugu S.
Nat Rev Mol Cell Biol. 2007 Jan;8(1):37-48. Review. PMID: 17183359
52. Rac-WAVE-mediated actin reorganization is required for organization and maintenance of cell-cell adhesion.
Yamazaki D, Oikawa T, Takenawa T.
J Cell Sci. 2007 Jan 1;120(Pt 1):86-100. PMID: 17164293
2006
53. Morphological change by overexpression of D385A dominant negative presenilin 1 in human neuroblastoma SH-SY5Y cells.
Tsuchiya D, Kitamura Y, Takata K, Taniguchi T, Uemura K, Miki H, Takenawa T, Shimohama S.
J Pharmacol Sci. 2006 Nov;102(3):354-8. PMID: 17099291
54. Developmental expression of neural Wiskott-Aldrich syndrome protein (N-WASP) and WASP family verprolin-homologous protein (WAVE)-related proteins in postnatal rat cerebral cortex and hippocampus.
Tsuchiya D, Kitamura Y, Takata K, Sugisaki T, Taniguchi T, Uemura K, Miki H, Takenawa T, Shimohama S.
Neurosci Res. 2006 Dec;56(4):459-69. PMID: 17049400
55. The RAC binding domain/IRSp53-MIM homology domain of IRSp53 induces RAC-dependent membrane deformation.
Suetsugu S, Murayama K, Sakamoto A, Hanawa-Suetsugu K, Seto A, Oikawa T, Mishima C, Shirouzu M, Takenawa T, Yokoyama S.
J Biol Chem. 2006 Nov 17;281(46):35347-58. PMID: 17003044
56. Disruption of phospholipase Cdelta4 gene modulates the liver regeneration in cooperation with nuclear protein kinase C.
Akutagawa A, Fukami K, Banno Y, Takenawa T, Kannagi R, Yokoyama Y, Oda K, Nagino M, Nimura Y, Yoshida S, Tamiya-Koizumi K.
J Biochem. 2006 Nov;140(5):619-25. PMID: 16998201
57. Application of phosphoinositide-binding domains for the detection and quantification of specific phosphoinositides.
Furutani M, Tsujita K, Itoh T, Ijuin T, Takenawa T.
Anal Biochem. 2006 Aug 1;355(1):8-18. PMID: 16814242
58. Modulation of GABA(A) receptor phosphorylation and membrane trafficking by phospholipase C-related inactive protein/protein phosphatase 1 and 2A signaling complex underlying brain-derived neurotrophic factor-dependent regulation of GABAergic inhibition.
Kanematsu T, Yasunaga A, Mizoguchi Y, Kuratani A, Kittler JT, Jovanovic JN, Takenaka K, Nakayama KI, Fukami K, Takenawa T, Moss SJ, Nabekura J, Hirata M.
J Biol Chem. 2006 Aug 4;281(31):22180-9. PMID: 16754670
59. Membrane targeting and remodeling through phosphoinositide-binding domains.
Takenawa T, Itoh T.
IUBMB Life. 2006 May-Jun;58(5-6):296-303. Review. PMID: 16754321
60. Optimization of WAVE2 complex-induced actin polymerization by membrane-bound IRSp53, PIP(3), and Rac.
Suetsugu S, Kurisu S, Oikawa T, Yamazaki D, Oda A, Takenawa T.
J Cell Biol. 2006 May 22;173(4):571-85. PMID: 16702231
61. Thin layer chromatography-blotting, a novel method for the detection of phosphoinositides.
Furutani M, Itoh T, Ijuin T, Tsujita K, Takenawa T.
J Biochem. 2006 Apr;139(4):663-70. PMID: 16672266
62. Protein kinase A-dependent increase in WAVE2 expression induced by the focal adhesion protein vinexin.
Mitsushima M, Sezaki T, Akahane R, Ueda K, Suetsugu S, Takenawa T, Kioka N.
Genes Cells. 2006 Mar;11(3):281-92. PMID: 16483316
63. Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis.
Tsujita K, Suetsugu S, Sasaki N, Furutani M, Oikawa T, Takenawa T.
J Cell Biol. 2006 Jan 16;172(2):269-79. PMID: 16418535
64. Caenorhabditis elegans WASP-interacting protein homologue WIP-1 is involved in morphogenesis through maintenance of WSP-1 protein levels.
Sawa M, Takenawa T.
Biochem Biophys Res Commun. 2006 Feb 10;340(2):709-17. PMID: 16378591
2005
65. CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation.
Kawano Y, Yoshimura T, Tsuboi D, Kawabata S, Kaneko-Kawano T, Shirataki H, Takenawa T, Kaibuchi K.
Mol Cell Biol. 2005 Nov;25(22):9920-35. PMID: 16260607
66. Regulation of cancer cell motility through actin reorganization.
Yamazaki D, Kurisu S, Takenawa T.
Cancer Sci. 2005 Jul;96(7):379-86. Review. PMID: 16053508
67. A novel function of WAVE in lamellipodia: WAVE1 is required for stabilization of lamellipodial protrusions during cell spreading.
Yamazaki D, Fujiwara T, Suetsugu S, Takenawa T.
Genes Cells. 2005 May;10(5):381-92. PMID: 15836768
68. Interaction of HSP90 to N-WASP leads to activation and protection from proteasome-dependent degradation.
Park SJ, Suetsugu S, Takenawa T.
EMBO J. 2005 Apr 20;24(8):1557-70. PMID: 15791211
69. WASP-related proteins, Abi1 and Ena/VASP are required for Listeria invasion induced by the Met receptor.
Bierne H, Miki H, Innocenti M, Scita G, Gertler FB, Takenawa T, Cossart P.
J Cell Sci. 2005 Apr 1;118(Pt 7):1537-47. PMID: 15769844
70. WICH, a member of WASP-interacting protein family, cross-links actin filaments.
Kato M, Takenawa T.
Biochem Biophys Res Commun. 2005 Mar 25;328(4):1058-66. PMID: 15707985
71. Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin.
Yamaguchi H, Lorenz M, Kempiak S, Sarmiento C, Coniglio S, Symons M, Segall J, Eddy R, Miki H, Takenawa T, Condeelis J.
J Cell Biol. 2005 Jan 31;168(3):441-52. PMID: 15684033
72. Rac-WAVE2 signaling is involved in the invasive and metastatic phenotypes of murine melanoma cells.
Kurisu S, Suetsugu S, Yamazaki D, Yamaguchi H, Takenawa T.
Oncogene. 2005 Feb 17;24(8):1309-19. PMID: 15608687
