業績

2021

A lack of ChREBP inhibits mitochondrial cristae formation in brown adipose tissue.
Sakiyama H, Li L, Kuwahara-Otani S, Nakagawa T, Eguchi H, Yoshihara D, Shinohara M, Fujiwara N, Suzuki K.
Mol Cell Biochem. 2021 May 21. doi: 10.1007/s11010-021-04178-2. Online ahead of print. PMID: 34021470

 

Canagliflozin ameliorates hepatic fat deposition in obese diabetic mice: Role of prostaglandin E2.
Yoshino K, Hosooka T, Shinohara M, Aoki C, Hosokawa Y, Imamori M, Ogawa W.
Biochem Biophys Res Commun. 2021 Jun 11;557:62-68. doi: 10.1016/j.bbrc.2021.04.012. Epub 2021 Apr 13. PMID: 338624610

 

Accessory pathway analysis using a multimodal deep learning model.
Nishimori M, Kiuchi K, Nishimura K, Kusano K, Yoshida A, Adachi K, Hirayama Y, Miyazaki Y, Fujiwara R, Sommer P, El Hamriti M, Imada H, Takemoto M, Takami M, Shinohara M, Toh R, Fukuzawa K, Hirata KI.
Sci Rep. 2021 Apr 13;11(1):8045. doi: 10.1038/s41598-021-87631-y. PMID: 33850245

 

Pemafibrate, A Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator, Reduces Plasma Eicosanoid Levels and Ameliorates Endothelial Dysfunction in Diabetic Mice.
Suto K, Fukuda D, Shinohara M, Ganbaatar B, Yagi S, Kusunose K, Yamada H, Soeki T, Hirata KI, Sata M.
J Atheroscler Thromb. 2021 Mar 27. doi: 10.5551/jat.61101. Online ahead of print. PMID: 33775978

 

Mobilization efficiency is critically regulated by fat via marrow PPARδ.
Suzuki T, Ishii S, Shinohara M, Kawano Y, Wakahashi K, Kawano H, Sada A, Minagawa K, Hamada M, Takahashi S, Furuyashiki T, Tan NS, Matsui T, Katayama Y.
Haematologica. 2021 Jun 1;106(6):1671-1683. doi: 10.3324/haematol.2020.265751. PMID: 33538151

 

Metabolic changes and anti-tumor effects of a ketogenic diet combined with anti-angiogenic therapy in a glioblastoma mouse model.
Maeyama M, Tanaka K, Nishihara M, Irino Y, Shinohara M, Nagashima H, Tanaka H, Nakamizo S, Hashiguchi M, Fujita Y, Kohta M, Kohmura E, Sasayama T.
Sci Rep. 2021 Jan 8;11(1):79. doi: 10.1038/s41598-020-79465-x. PMID: 33420169 1

 

Critical role of glutamine metabolism in cardiomyocytes under oxidative stress.
Watanabe K, Nagao M, Toh R, Irino Y, Shinohara M, Iino T, Yoshikawa S, Tanaka H, Satomi-Kobayashi S, Ishida T, Hirata KI.
Biochem Biophys Res Commun. 2021 Jan 1;534:687-693. doi: 10.1016/j.bbrc.2020.11.018. Epub 2020 Nov 17. PMID: 33213841

 

2020

Empagliflozin ameliorates endothelial dysfunction and suppresses atherogenesis in diabetic apolipoprotein E-deficient mice.
Ganbaatar B, Fukuda D, Shinohara M, Yagi S, Kusunose K, Yamada H, Soeki T, Hirata KI, Sata M.
Eur J Pharmacol. 2020 Feb 27;875:173040. [Epub ahead of print] PMID: 32114052

 

Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice.
Kimura I, Miyamoto J, Ohue-Kitano R, Watanabe K, Yamada T, Onuki M, Aoki R, Isobe Y, Kashihara D, Inoue D, Inaba A, Takamura Y, Taira S, Kumaki S, Watanabe M, Ito M, Nakagawa F, Irie J, Kakuta H, Shinohara M, Iwatsuki K, Tsujimoto G, Ohno H, Arita M, Itoh H, Hase K.
Science. 2020 Feb 28;367(6481). PMID: 32108090

 

Association of cholesterol uptake capacity, a novel indicator for HDL functionality, and coronary plaque properties: An optical coherence tomography-based observational study.
Oshita T, Toh R, Nagano Y, Kuroda K, Nagasawa Y, Harada A, Murakami K, Kiriyama M, Yoshikawa K, Miwa K, Kubo T, Iino T, Nagao M, Irino Y, Hara T, Shinohara M, Otake H, Shinke T, Nakajima K, Ishida T, Hirata KI.
Clin Chim Acta. 2020 Apr;503:136-144. PMID: 31972150

 

Recombinant human thrombomodulin attenuated sepsis severity in a non-surgical preterm mouse model.
Ashina M, Fujioka K, Nishida K, Okubo S, Ikuta T, Shinohara M, Iijima K.
Sci Rep. 2020 Jan 15;10(1):333. PMID: 31941991

 

2019

Roles of Toll-like receptor 2/4, monoacylglycerol lipase, and cyclooxygenase in social defeat stress-induced prostaglandin E2 synthesis in the brain and their behavioral relevance.
Nie X, Kitaoka S, Shinohara M, Kakizuka A, Narumiya S, Furuyashiki T.
Sci Rep. 2019 Nov 26;9(1):17548. PMID: 31772309

 

Serum elaidic acid concentration and risk of dementia: The Hisayama study.
Honda T, Ohara T, Shinohara M, Hata J, Toh R, Yoshida D, Shibata M, Ishida T, Hirakawa Y, Irino Y, Sakata S, Uchida K, Kitazono T, Kanba S, Hirata KI, Ninomiya T.
Neurology. 2019 Nov 26;93(22):e2053-e2064. PMID: 31645469

 

Serum concentration of full-length- and carboxy-terminal fragments of endothelial lipase predicts future cardiovascular risks in patients with coronary artery disease.
Nagao M, Miyashita K, Mori K, Irino Y, Toh R, Hara T, Hirata KI, Shinohara M, Nakajima K, Ishida T.
J J Clin Lipidol. 2019 Jul 29.2019 Sep - Oct;13(5):839-846. PMID: 31473149

 

Change in brain plasmalogen composition by exposure to prenatal undernutrition leads to behavioral impairment of rats.
Hino K, Kaneko S, Harasawa T, Kimura T, Takei S, Shinohara M, Yamazaki F, Morita SY, Sato S, Kubo Y, Kono T, Setou M, Yoshioka M, Fujino J, Sugihara H, Kojima H, Yamada N, Udagawa J.
J Neurosci. 2019 Aug 7 PMID: 31391260

 

Effect of Rosuvastatin and Eicosapentaenoic Acid on Neoatherosclerosis: The LINK-IT Trial.
Kuroda K, Otake H, Shinohara M, Kuroda M, Tsuda S, Toba T, Nagano Y, Toh R, Ishida T, Shinke T, Hirata KI.
EuroIntervention. 2019 Jul 23. PMID: 31334703

 

Identification of novel serum markers for the progression of coronary atherosclerosis in WHHLMI rabbits, an animal model of familial hypercholesterolemia.
Shiomi M, Takeda H, Irino Y, Kimura N, Yamada S, Kuniyoshi N, Kikumori A, Koike Y, Koike T, Yoshida M, Izumi Y, Shinohara M, Bamba T, Ishida T.
Atherosclerosis. 2019 Feb 28;284:18-23. PMID: 30870703

 

Elevated Serum Elaidic Acid Predicts Risk of Repeat Revascularization After Percutaneous Coronary Intervention in Japan.
Oshita T, Toh R, Shinohara M, Mori K, Irino Y, Nagao M, Hara T, Otake H, Ishida T, Hirata KI.
Circ J. 2019 Mar 13. doi: 10.1253/circj.CJ-18-1175. PMID: 30867359

 

2018

Gut Microbiome and Plasma Microbiome-Related Metabolites in Patients With Decompensated and Compensated Heart Failure.
Hayashi T, Yamashita T, Watanabe H, Kami K, Yoshida N, Tabata T, Emoto T, Sasaki N, Mizoguchi T, Irino Y, Toh R, Shinohara M, Okada Y, Ogawa W, Yamada T, Hirata KI.
Circ J. 2018 Dec 25;83(1):182-192. doi: 10.1253/circj.CJ-18-0468. PMID: 30487369

 

Modulation of lipid mediator profile may contribute to amelioration of chronic inflammation in adipose tissue of obese mice by pioglitazone.
Okada K, Hosooka T, Shinohara M, Ogawa W.
Biochem Biophys Res Commun. 2018 Oct 20;505(1):29-35. PMID: 30236987

 

Behavioral effects of long-term oral administration of aluminum ammonium sulfate in male and female C57BL/6J mice.
Shoji H, Irino Y, Yoshida M, Miyakawa T.
Neuropsychopharmacol Rep. 2018 Mar;38(1):18-36. PMID: 30106265

 

Pentose phosphate pathway activation via HSP27 phosphorylation by ATM kinase: A putative endogenous antioxidant defense mechanism during cerebral ischemia-reperfusion.
Yamamoto Y, Hosoda K, Imahori T, Tanaka J, Matsuo K, Nakai T, Irino Y, Shinohara M, Sato N, Sasayama T, Tanaka K, Nagashima H, Kohta M, Kohmura E.
Brain Res. 2018 May 15;1687:82-94. PMID: 29510140

 

Glutamate production from ammonia via glutamate dehydrogenase 2 activity supports cancer cell proliferation under glutamine depletion.
Takeuchi Y, Nakayama Y, Fukusaki E, Irino Y.
Biochem Biophys Res Commun. 2018 Jan 1;495(1):761-767. PMID: 29146184

 

2017

Novel mechanism of regulation of the 5-lipoxygenase/leukotriene B4 pathway by high-density lipoprotein in macrophages.
Tsuda S, Shinohara M, Oshita T, Nagao M, Tanaka N, Mori T, Hara T, Irino Y, Toh R, Ishida T, Hirata KI.
Sci Rep. 2017 Oct 11;7(1):12989. doi: 10.1038/s41598-017-13154-0. PMID: 29021582

 

High-density lipoprotein protects cardiomyocytes from oxidative stress via the PI3K/mTOR signaling pathway.
Nagao M, Toh R, Irino Y, Nakajima H, Oshita T, Tsuda S, Hara T, Shinohara M, Ishida T, Hirata KI.
FEBS Open Bio. 2017 Aug 14;7(9):1402-1409. doi: 10.1002/2211-5463.12279. eCollection 2017 Sep. PMID: 28904868

 

Targeted Disruption of JCAD (Junctional Protein Associated With Coronary Artery Disease)/KIAA1462, a Coronary Artery Disease-Associated Gene Product, Inhibits Angiogenic Processes In Vitro and In Vivo.
Hara T, Monguchi T, Iwamoto N, Akashi M, Mori K, Oshita T, Okano M, Toh R, Irino Y, Shinohara M, Yamashita Y, Shioi G, Furuse M, Ishida T, Hirata KI.
Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1667-1673. doi: 10.1161/ATVBAHA.117.309721. Epub 2017 Jul 13. PMID: 28705794

 

Eicosapentaenoic Acid-Enriched High-Density Lipoproteins Exhibit Anti-Atherogenic Properties.
Tanaka N, Irino Y, Shinohara M, Tsuda S, Mori T, Nagao M, Oshita T, Mori K, Hara T, Toh R, Ishida T, Hirata KI.
Circ J 2017 in press. PMID: 28652532

 

Association between Serum Elaidic acid Concentration and Insulin Resistance in Two Japanese Cohorts with Different Lifestyles.
Itcho K, Yoshii Y, Ohno H, Oki K, Shinohara M, Irino Y, Toh R, Ishida T, Hirata KI, Yoneda M.
J Atheroscler Thromb. 2017 in press. PMID: 28484112

 

Combined metabolic and transcriptional profiling identifies pentose phosphate pathway activation by HSP27 phosphorylation during cerebral ischemia.
Imahori T, Hosoda K, Nakai T, Yamamoto Y, Irino Y, Shinohara M, Sato N, Sasayama T, Tanaka K, Nagashima H, Kohta M, Kohmura E.
Neuroscience. 2017 May 4;349:1-16. PMID: 28257891

 

Excessive intake of trans fatty acid accelerates atherosclerosis through promoting inflammation and oxidative stress in a mouse model of hyperlipidemia.
Monguchi T, Hara T, Hasokawa M, Nakajima H, Mori K, Toh R, Irino Y, Ishida T, Hirata KI, Shinohara M.
J Cardiol. 2017 in press. PMID: 28254384

 

NLRP3 Inflammasome Deficiency Protects Against Microbial Sepsis via Increased Lipoxin B4 Synthesis.
Lee S, Nakahira K, Dalli J, Siempos II, Norris PC, Colas RA, Moon JS, Shinohara M, Hisata S, Howrylak JA, Suh GY, Ryter SW, Serhan CN, Choi AM.
Am J Respir Crit Care Med. 2017 in press. PMID: 28245134

 

2016

2-Aminobutyric acid modulates glutathione homeostasis in the myocardium.
Irino Y, Toh R, Nagao M, Mori T, Honjo T, Shinohara M, Tsuda S, Nakajima H, Satomi-Kobayashi S, Shinke T, Tanaka H, Ishida T, Miyata O, Hirata KI.
Sci Rep. 2016 Nov 9;6:36749. PMID: 27827456

 

G-CSF-induced sympathetic tone provokes fever and primes anti-mobilizing functions of neutrophils via PGE2.
Kawano Y, Fukui C, Shinohara M, Wakahashi K, Ishii S, Suzuki T, Sato M, Asada N, Kawano H, Minagawa K, Sada A, Furuyashiki T, Uematsu S, Akira S, Uede T, Narumiya S, Matsui T, Katayama Y.
Blood 2016 in publication. PMID: 27827823

 

Promotion of Intestinal Epithelial Cell Turnover by Commensal Bacteria: Role of Short-Chain Fatty Acids.
Park JH, Kotani T, Konno T, Setiawan J, Kitamura Y, Imada S, Usui Y, Hatano N, Shinohara M, Saito Y, Murata Y, Matozaki T.
PLoS One. 2016 May 27;11(5):e0156334. PMID: 27232601

 

Novel Endogenous Proresolving Molecules: Essential Fatty Acid-Derived and Gaseous Mediators in the Resolution of Inflammation.
Shinohara M, Serhan CN.
J Atheroscler Thromb.2016 Jun 1;23(6):655-64. PMID: 27052783

 

Alterations of Hepatic Metabolism in Chronic Kidney Disease via D-box-binding Protein Aggravate the Renal Dysfunction.
Hamamura K, Matsunaga N, Ikeda E, Kondo H, Ikeyama H, Tokushige K, Itcho K, Furuichi Y, Yoshida Y, Matsuda M, Yasuda K, Doi A, Yokota Y, Amamoto T, Aramaki H, Irino Y, Koyanagi S, Ohdo S.
J Biol Chem.2016 Mar 4;291(10):4913-27. PMID: 26728457

 

2015

Identification of putative biomarkers for prediabetes by metabolome analysis of rat models of type 2 diabetes.
Yokoi N, Beppu M, Yoshida E, Hoshikawa R, Hidaka S, Matsubara T, Shinohara M, Irino Y, Hatano N, Seino S.
Metabolomics.2015;11(5):1277-1286. PMID: 26366137

 

Metabolomic profiling in inner ear fluid by gas chromatography/mass spectrometry in guinea pig cochlea.
Fujita T, Yamashita D, Irino Y, Kitamoto J, Fukuda Y, Inokuchi G, Hasegawa S, Otsuki N, Yoshida M, Nibu K.
Neurosci Lett.2015 Oct 8;606:188-93. PMID: 26343935

 

Metabolomics analysis of saliva from patients with primary Sjögren's syndrome.
Kageyama G, Saegusa J, Irino Y, Tanaka S, Tsuda K, Takahashi S, Sendo S, Morinobu A.
Clin Exp Immunol.2015 Nov;182(2):149-53. PMID: 26201380

 

Serum Trans-Fatty Acid Concentration Is Elevated in Young Patients With Coronary Artery Disease in Japan.
Mori K, Ishida T, Yasuda T, Hasokawa M, Monguchi T, Sasaki M, Kondo K, Nakajima H, Shinohara M, Shinke T, Irino Y, Toh R, Nishimura K, Hirata KI.
Circ J.2015;79(9):2017-25. PMID: 26166015

 

Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment.
Tanaka K, Sasayama T, Irino Y, Takata K, Nagashima H, Satoh N, Kyotani K, Mizowaki T, Imahori T, Ejima Y, Masui K, Gini B, Yang H, Hosoda K, Sasaki R, Mischel PS, Kohmura E.
J Clin Invest.2015 in press PMID: 25798620

 

Proresolving Lipid Mediator Profiles in Baboon Pneumonia are Regulated by Inhaled Carbon Monoxide.
Dalli J, Kraft BD, Colas RA, Shinohara M, Fredenburgh LE, Hess DR, Chiang N, Welty-Wolf KE, Choi AM, Piantadosi CA, Serhan CN.
Am J Respir Cell Mol Biol.2015 Sep;53(3):314-25. PMID: 25568926

 

2014

Glutamate acts as a key signal linking glucose metabolism to incretin/cAMP action to amplify insulin secretion.
Gheni G, Ogura M, Iwasaki M, Yokoi N, Minami K, Nakayama Y, Harada K, Hastoy B, Wu X, Takahashi H, Kimura K, Matsubara T, Hoshikawa R, Hatano N, Sugawara K, Shibasaki T, Inagaki N, Bamba T, Mizoguchi A, Fukusaki E, Rorsman P, Seino S.
Cell Rep. 2014 Oct 23;9(2):661-73. PMID: 25373904

 

Cell-Cell Interactions and Bronchoconstrictor Eicosanoid Reduction With Inhaled Carbon Monoxide and Resolvin D1.
Shinohara M, Kibi M, Riley IR, Chiang N, Dalli J, Kraft BD, Piantadosi CA, Choi AM, Serhan CN.
Am J Physiol Lung Cell Mol Physiol. 2014 Nov 15;307(10):L746-57 PMID: 25217660

 

Aging Delays Resolution of Acute Inflammation in Mice: Reprogramming the Host Response with Novel Nanoproresolving Medicines.
Arnardottir HH, Dalli J, Colas RA, Shinohara M, Serhan CN.
J Immunol 2014 Oct 15;193(8):4235-44 PMID: 25217168

 

Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue.
Colas RA, Shinohara M, Dalli J, Chiang N, Serhan CN.
Am J Physiol Cell Physiol. 2014 Jul 1;307(1):C39-54. PMID: 24696140

 

2013

Inhaled carbon monoxide accelerates resolution of inflammation via unique proresolving mediator-heme oxygenase-1 circuits.
Chiang N, Shinohara M, Dalli J, Mirakaj V, Kibi M, Choi AM, Serhan CN.
J Immunol. 2013 Jun 15;190(12):6378-88. PMID: 23650615

 

2012

Role of Phosphatidylinositol 3,4,5-trisphosphate (PIP3) 5-phosphatase, skeletal muscle and kidney enriched inositol polyphosphate phosphatase (SKIP) in myoblast differentiation.
Ijuin T, Takenawa T.
J Biol Chem. 2012 Jul 19. PMID: 22815484

 

Regulation of Insulin Signaling by the Phosphatidylinositol 3,4,5-Triphosphate Phosphatase SKIP through the Scaffolding Function of Pak1.
Ijuin T, Takenawa T.
Mol Cell Biol.
2012 Sep;32(17):3570-84. PMID: 22751929

 

Quantification and visualization of phosphoinositides by quantum dot-labeled specific binding-domain probes.
Irino Y, Tokuda E, Hasegawa J, Itoh T, Takenawa T.
J Lipid Res. 2012 Apr;53(4):810-9. PMID: 22308508

 

Regulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP).
Ijuin T, Takenawa T.
J Biol Chem
. 2012 Mar 2;287(10):6991-9. Epub 2012 Jan 15. PMID: 22247557

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2011

SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain.
Hasegawa J, Tokuda E, Tenno T, Tsujita K, Sawai H, Hiroaki H, Takenawa T, Itoh T.
J Cell Biol. 2011 May 30;193(5):901-16.PMID: 21624956

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2010

WASP and WAVE family proteins: friends or foes in cancer invasion?
Kurisu S, Takenawa T.
Cancer Sci. 2010 Oct;101(10):2093-104. Review. PMID: 20707804

 

Phosphoinositide-binding interface proteins involved in shaping cell membranes.
Takenawa T.
Proc Jpn Acad Ser B Phys Biol Sci. 2010;86(5):509-23. Review. PMID: 20467216

 

Proteome of acidic phospholipid-binding proteins: spatial and temporal regulation of Coronin 1A by phosphoinositides.
Tsujita K, Itoh T, Kondo A, Oyama M, Kozuka-Hata H, Irino Y, Hasegawa J, Takenawa T.
J Biol Chem. 2010 Feb 26;285(9):6781-9. Epub 2009 Dec 22. PMID: 20032464

 

2009

The tyrosine kinase Fer is a downstream target of the PLD-PA pathway that regulates cell migration.
Itoh T, Hasegawa J, Tsujita K, Kanaho Y, Takenawa T.
Sci Signal. 2009 Sep 8;2(87):ra52. PMID: 19738202

 

The WASP and WAVE family proteins.
Kurisu S, Takenawa T.
Genome Biol. 2009;10(6):226. Epub 2009 Jun 15. Review. PMID: 19589182

 

Mechanisms of membrane deformation by lipid-binding domains.
Itoh T, Takenawa T.
Prog Lipid Res. 2009 Sep;48(5):298-305. Epub 2009 May 27. Review. PMID: 19481110

 

PtdIns(3,4)P2 instigates focal adhesions to generate podosomes.
Oikawa T, Takenawa T.
Cell Adh Migr. 2009 Apr-Jun;3(2):195-7. Epub 2009 Apr 29. Review. PMID: 19262173

 

Involvement of Rac and Rho signaling in cancer cell motility in 3D substrates.
Yamazaki D, Kurisu S, Takenawa T.
Oncogene. 2009 Apr 2;28(13):1570-83. Epub 2009 Feb 23. PMID: 19234490

2008

Sequential signals toward podosome formation in NIH-src cells.
Oikawa T, Itoh T, Takenawa T.
J Cell Biol. 2008 Jul 14;182(1):157-69. Epub 2008 Jul 7. PMID: 18606851

 

Increased insulin action in SKIP heterozygous knockout mice.
Ijuin T, Yu YE, Mizutani K, Pao A, Tateya S, Tamori Y, Bradley A, Takenawa T.
Mol Cell Biol. 2008 Sep;28(17):5184-95. Epub 2008 Jun 23. PMID: 18573875

2007

Casein kinase 2-interacting protein-1, a novel Akt pleckstrin homology domain-interacting protein, down-regulates PI3K/Akt signaling and suppresses tumor growth in vivo.
Tokuda E, Fujita N, Oh-hara T, Sato S, Kurata A, Katayama R, Itoh T, Takenawa T, Miyazono K, Tsuruo T.
Cancer Res. 2007 Oct 15;67(20):9666-76. PMID: 17942896

 

The WASP-WAVE protein network: connecting the membrane to the cytoskeleton.
Takenawa T, Suetsugu S.
Nat Rev Mol Cell Biol. 2007 Jan;8(1):37-48. Review. PMID: 17183359

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