業績
2021
A lack of ChREBP inhibits mitochondrial cristae formation in brown adipose tissue.
Sakiyama H, Li L, Kuwahara-Otani S, Nakagawa T, Eguchi H, Yoshihara D, Shinohara M, Fujiwara N, Suzuki K.
Mol Cell Biochem. 2021 May 21. doi: 10.1007/s11010-021-04178-2. Online ahead of print.
PMID: 34021470
Canagliflozin ameliorates hepatic fat deposition in obese diabetic mice: Role of prostaglandin E2.
Yoshino K, Hosooka T, Shinohara M, Aoki C, Hosokawa Y, Imamori M, Ogawa W.
Biochem Biophys Res Commun. 2021 Jun 11;557:62-68. doi: 10.1016/j.bbrc.2021.04.012. Epub 2021 Apr 13.
PMID: 338624610
Accessory pathway analysis using a multimodal deep learning model.
Nishimori M, Kiuchi K, Nishimura K, Kusano K, Yoshida A, Adachi K, Hirayama Y, Miyazaki Y, Fujiwara R, Sommer P, El Hamriti M, Imada H, Takemoto M, Takami M, Shinohara M, Toh R, Fukuzawa K, Hirata KI.
Sci Rep. 2021 Apr 13;11(1):8045. doi: 10.1038/s41598-021-87631-y.
PMID: 33850245
Pemafibrate, A Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator, Reduces Plasma Eicosanoid Levels and Ameliorates Endothelial Dysfunction in Diabetic Mice.
Suto K, Fukuda D, Shinohara M, Ganbaatar B, Yagi S, Kusunose K, Yamada H, Soeki T, Hirata KI, Sata M.
J Atheroscler Thromb. 2021 Mar 27. doi: 10.5551/jat.61101. Online ahead of print.
PMID: 33775978
Mobilization efficiency is critically regulated by fat via marrow PPARδ.
Suzuki T, Ishii S, Shinohara M, Kawano Y, Wakahashi K, Kawano H, Sada A, Minagawa K, Hamada M, Takahashi S, Furuyashiki T, Tan NS, Matsui T, Katayama Y.
Haematologica. 2021 Jun 1;106(6):1671-1683. doi: 10.3324/haematol.2020.265751.
PMID: 33538151
Metabolic changes and anti-tumor effects of a ketogenic diet combined with anti-angiogenic therapy in a glioblastoma mouse model.
Maeyama M, Tanaka K, Nishihara M, Irino Y, Shinohara M, Nagashima H, Tanaka H, Nakamizo S, Hashiguchi M, Fujita Y, Kohta M, Kohmura E, Sasayama T.
Sci Rep. 2021 Jan 8;11(1):79. doi: 10.1038/s41598-020-79465-x.
PMID: 33420169 1
Critical role of glutamine metabolism in cardiomyocytes under oxidative stress.
Watanabe K, Nagao M, Toh R, Irino Y, Shinohara M, Iino T, Yoshikawa S, Tanaka H, Satomi-Kobayashi S, Ishida T, Hirata KI.
Biochem Biophys Res Commun. 2021 Jan 1;534:687-693. doi: 10.1016/j.bbrc.2020.11.018. Epub 2020 Nov 17.
PMID: 33213841
2020
Empagliflozin ameliorates endothelial dysfunction and suppresses atherogenesis in diabetic apolipoprotein E-deficient mice.
Ganbaatar B, Fukuda D, Shinohara M, Yagi S, Kusunose K, Yamada H, Soeki T, Hirata KI, Sata M.
Eur J Pharmacol. 2020 Feb 27;875:173040. [Epub ahead of print]
PMID: 32114052
Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice.
Kimura I, Miyamoto J, Ohue-Kitano R, Watanabe K, Yamada T, Onuki M, Aoki R, Isobe Y, Kashihara D, Inoue D, Inaba A, Takamura Y, Taira S, Kumaki S, Watanabe M, Ito M, Nakagawa F, Irie J, Kakuta H, Shinohara M, Iwatsuki K, Tsujimoto G, Ohno H, Arita M, Itoh H, Hase K.
Science. 2020 Feb 28;367(6481).
PMID: 32108090
Association of cholesterol uptake capacity, a novel indicator for HDL functionality, and coronary plaque properties: An optical coherence tomography-based observational study.
Oshita T, Toh R, Nagano Y, Kuroda K, Nagasawa Y, Harada A, Murakami K, Kiriyama M, Yoshikawa K, Miwa K, Kubo T, Iino T, Nagao M, Irino Y, Hara T, Shinohara M, Otake H, Shinke T, Nakajima K, Ishida T, Hirata KI.
Clin Chim Acta. 2020 Apr;503:136-144.
PMID: 31972150
Recombinant human thrombomodulin attenuated sepsis severity in a non-surgical preterm mouse model.
Ashina M, Fujioka K, Nishida K, Okubo S, Ikuta T, Shinohara M, Iijima K.
Sci Rep. 2020 Jan 15;10(1):333.
PMID: 31941991
2019
Roles of Toll-like receptor 2/4, monoacylglycerol lipase, and cyclooxygenase in social defeat stress-induced prostaglandin E2 synthesis in the brain and their behavioral relevance.
Nie X, Kitaoka S, Shinohara M, Kakizuka A, Narumiya S, Furuyashiki T.
Sci Rep. 2019 Nov 26;9(1):17548.
PMID: 31772309
Serum elaidic acid concentration and risk of dementia: The Hisayama study.
Honda T, Ohara T, Shinohara M, Hata J, Toh R, Yoshida D, Shibata M, Ishida T, Hirakawa Y, Irino Y, Sakata S, Uchida K, Kitazono T, Kanba S, Hirata KI, Ninomiya T.
Neurology. 2019 Nov 26;93(22):e2053-e2064.
PMID: 31645469
Serum concentration of full-length- and carboxy-terminal fragments of endothelial lipase predicts future cardiovascular risks in patients with coronary artery disease.
Nagao M, Miyashita K, Mori K, Irino Y, Toh R, Hara T, Hirata KI, Shinohara M, Nakajima K, Ishida T.
J J Clin Lipidol. 2019 Jul 29.2019 Sep - Oct;13(5):839-846.
PMID: 31473149
Change in brain plasmalogen composition by exposure to prenatal undernutrition leads to behavioral impairment of rats.
Hino K, Kaneko S, Harasawa T, Kimura T, Takei S, Shinohara M, Yamazaki F, Morita SY, Sato S, Kubo Y, Kono T, Setou M, Yoshioka M, Fujino J, Sugihara H, Kojima H, Yamada N, Udagawa J.
J Neurosci. 2019 Aug 7
PMID: 31391260
Effect of Rosuvastatin and Eicosapentaenoic Acid on Neoatherosclerosis: The LINK-IT Trial.
Kuroda K, Otake H, Shinohara M, Kuroda M, Tsuda S, Toba T, Nagano Y, Toh R, Ishida T, Shinke T, Hirata KI.
EuroIntervention. 2019 Jul 23.
PMID: 31334703
Identification of novel serum markers for the progression of coronary atherosclerosis in WHHLMI rabbits, an animal model of familial hypercholesterolemia.
Shiomi M, Takeda H, Irino Y, Kimura N, Yamada S, Kuniyoshi N, Kikumori A, Koike Y, Koike T, Yoshida M, Izumi Y, Shinohara M, Bamba T, Ishida T.
Atherosclerosis. 2019 Feb 28;284:18-23.
PMID: 30870703
Elevated Serum Elaidic Acid Predicts Risk of Repeat Revascularization After Percutaneous Coronary Intervention in Japan.
Oshita T, Toh R, Shinohara M, Mori K, Irino Y, Nagao M, Hara T, Otake H, Ishida T, Hirata KI.
Circ J. 2019 Mar 13. doi: 10.1253/circj.CJ-18-1175.
PMID: 30867359
2018
Gut Microbiome and Plasma Microbiome-Related Metabolites in Patients With Decompensated and Compensated Heart Failure.
Hayashi T, Yamashita T, Watanabe H, Kami K, Yoshida N, Tabata T, Emoto T, Sasaki N, Mizoguchi T, Irino Y, Toh R, Shinohara M, Okada Y, Ogawa W, Yamada T, Hirata KI.
Circ J. 2018 Dec 25;83(1):182-192. doi: 10.1253/circj.CJ-18-0468.
PMID: 30487369
Modulation of lipid mediator profile may contribute to amelioration of chronic inflammation in adipose tissue of obese mice by pioglitazone.
Okada K, Hosooka T, Shinohara M, Ogawa W.
Biochem Biophys Res Commun. 2018 Oct 20;505(1):29-35.
PMID: 30236987
Behavioral effects of long-term oral administration of aluminum ammonium sulfate in male and female C57BL/6J mice.
Shoji H, Irino Y, Yoshida M, Miyakawa T.
Neuropsychopharmacol Rep. 2018 Mar;38(1):18-36.
PMID: 30106265
Pentose phosphate pathway activation via HSP27 phosphorylation by ATM kinase: A putative endogenous antioxidant defense mechanism during cerebral ischemia-reperfusion.
Yamamoto Y, Hosoda K, Imahori T, Tanaka J, Matsuo K, Nakai T, Irino Y, Shinohara M, Sato N, Sasayama T, Tanaka K, Nagashima H, Kohta M, Kohmura E.
Brain Res. 2018 May 15;1687:82-94.
PMID: 29510140
Glutamate production from ammonia via glutamate dehydrogenase 2 activity supports cancer cell proliferation under glutamine depletion.
Takeuchi Y, Nakayama Y, Fukusaki E, Irino Y.
Biochem Biophys Res Commun. 2018 Jan 1;495(1):761-767.
PMID: 29146184
2017
Novel mechanism of regulation of the 5-lipoxygenase/leukotriene B4 pathway by high-density lipoprotein in macrophages.
Tsuda S, Shinohara M, Oshita T, Nagao M, Tanaka N, Mori T, Hara T, Irino Y, Toh R, Ishida T, Hirata KI.
Sci Rep. 2017 Oct 11;7(1):12989. doi: 10.1038/s41598-017-13154-0.
PMID: 29021582
High-density lipoprotein protects cardiomyocytes from oxidative stress via the PI3K/mTOR signaling pathway.
Nagao M, Toh R, Irino Y, Nakajima H, Oshita T, Tsuda S, Hara T, Shinohara M, Ishida T, Hirata KI.
FEBS Open Bio. 2017 Aug 14;7(9):1402-1409. doi: 10.1002/2211-5463.12279. eCollection 2017 Sep.
PMID: 28904868
Targeted Disruption of JCAD (Junctional Protein Associated With Coronary Artery Disease)/KIAA1462, a Coronary Artery Disease-Associated Gene Product, Inhibits Angiogenic Processes In Vitro and In Vivo.
Hara T, Monguchi T, Iwamoto N, Akashi M, Mori K, Oshita T, Okano M, Toh R, Irino Y, Shinohara M, Yamashita Y, Shioi G, Furuse M, Ishida T, Hirata KI.
Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1667-1673. doi: 10.1161/ATVBAHA.117.309721. Epub 2017 Jul 13.
PMID: 28705794
Eicosapentaenoic Acid-Enriched High-Density Lipoproteins Exhibit Anti-Atherogenic Properties.
Tanaka N, Irino Y, Shinohara M, Tsuda S, Mori T, Nagao M, Oshita T, Mori K, Hara T, Toh R, Ishida T, Hirata KI.
Circ J 2017 in press. PMID: 28652532
Association between Serum Elaidic acid Concentration and Insulin Resistance in Two Japanese Cohorts with Different Lifestyles.
Itcho K, Yoshii Y, Ohno H, Oki K, Shinohara M, Irino Y, Toh R, Ishida T, Hirata KI, Yoneda M.
J Atheroscler Thromb. 2017 in press. PMID: 28484112
Combined metabolic and transcriptional profiling identifies pentose phosphate pathway activation by HSP27 phosphorylation during cerebral ischemia.
Imahori T, Hosoda K, Nakai T, Yamamoto Y, Irino Y, Shinohara M, Sato N, Sasayama T, Tanaka K, Nagashima H, Kohta M, Kohmura E.
Neuroscience. 2017 May 4;349:1-16. PMID: 28257891
Excessive intake of trans fatty acid accelerates atherosclerosis through promoting inflammation and oxidative stress in a mouse model of hyperlipidemia.
Monguchi T, Hara T, Hasokawa M, Nakajima H, Mori K, Toh R, Irino Y, Ishida T, Hirata KI, Shinohara M.
J Cardiol. 2017 in press. PMID: 28254384
NLRP3 Inflammasome Deficiency Protects Against Microbial Sepsis via Increased Lipoxin B4 Synthesis.
Lee S, Nakahira K, Dalli J, Siempos II, Norris PC, Colas RA, Moon JS, Shinohara M, Hisata S, Howrylak JA, Suh GY, Ryter SW, Serhan CN, Choi AM.
Am J Respir Crit Care Med. 2017 in press. PMID: 28245134
2016
2-Aminobutyric acid modulates glutathione homeostasis in the myocardium.
Irino Y, Toh R, Nagao M, Mori T, Honjo T, Shinohara M, Tsuda S, Nakajima H, Satomi-Kobayashi S, Shinke T, Tanaka H, Ishida T, Miyata O, Hirata KI.
Sci Rep. 2016 Nov 9;6:36749. PMID: 27827456
G-CSF-induced sympathetic tone provokes fever and primes anti-mobilizing functions of neutrophils via PGE2.
Kawano Y, Fukui C, Shinohara M, Wakahashi K, Ishii S, Suzuki T, Sato M, Asada N, Kawano H, Minagawa K, Sada A, Furuyashiki T, Uematsu S, Akira S, Uede T, Narumiya S, Matsui T, Katayama Y.
Blood 2016 in publication. PMID: 27827823
Promotion of Intestinal Epithelial Cell Turnover by Commensal Bacteria: Role of Short-Chain Fatty Acids.
Park JH, Kotani T, Konno T, Setiawan J, Kitamura Y, Imada S, Usui Y, Hatano N, Shinohara M, Saito Y, Murata Y, Matozaki T.
PLoS One. 2016 May 27;11(5):e0156334. PMID: 27232601
Novel Endogenous Proresolving Molecules:
Essential Fatty Acid-Derived and Gaseous Mediators in the Resolution of Inflammation.
Shinohara M, Serhan CN.
J Atheroscler Thromb.2016 Jun 1;23(6):655-64. PMID: 27052783
Alterations of Hepatic Metabolism in Chronic Kidney Disease via D-box-binding Protein Aggravate the Renal Dysfunction.
Hamamura K, Matsunaga N, Ikeda E, Kondo H, Ikeyama H, Tokushige K, Itcho K, Furuichi Y, Yoshida Y, Matsuda M, Yasuda K, Doi A, Yokota Y, Amamoto T, Aramaki H, Irino Y, Koyanagi S, Ohdo S.
J Biol Chem.2016 Mar 4;291(10):4913-27. PMID: 26728457
2015
Identification of putative biomarkers for prediabetes by metabolome analysis of rat models of type 2 diabetes.
Yokoi N, Beppu M, Yoshida E, Hoshikawa R, Hidaka S, Matsubara T, Shinohara M, Irino Y, Hatano N, Seino S.
Metabolomics.2015;11(5):1277-1286. PMID: 26366137
Metabolomic profiling in inner ear fluid by gas chromatography/mass spectrometry in guinea pig cochlea.
Fujita T, Yamashita D, Irino Y, Kitamoto J, Fukuda Y, Inokuchi G, Hasegawa S, Otsuki N, Yoshida M, Nibu K.
Neurosci Lett.2015 Oct 8;606:188-93. PMID: 26343935
Metabolomics analysis of saliva from patients with primary Sjögren's syndrome.
Kageyama G, Saegusa J, Irino Y, Tanaka S, Tsuda K, Takahashi S, Sendo S, Morinobu A.
Clin Exp Immunol.2015 Nov;182(2):149-53. PMID: 26201380
Serum Trans-Fatty Acid Concentration Is Elevated in Young Patients With Coronary Artery Disease in Japan.
Mori K, Ishida T, Yasuda T, Hasokawa M, Monguchi T, Sasaki M, Kondo K, Nakajima H, Shinohara M, Shinke T, Irino Y, Toh R, Nishimura K, Hirata KI.
Circ J.2015;79(9):2017-25. PMID: 26166015
Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment.
Tanaka K, Sasayama T, Irino Y, Takata K, Nagashima H, Satoh N, Kyotani K, Mizowaki T, Imahori T, Ejima Y, Masui K, Gini B, Yang H, Hosoda K, Sasaki R, Mischel PS, Kohmura E.
J Clin Invest.2015 in press PMID: 25798620
Proresolving Lipid Mediator Profiles in Baboon Pneumonia are Regulated by Inhaled Carbon Monoxide.
Dalli J, Kraft BD, Colas RA, Shinohara M, Fredenburgh LE, Hess DR, Chiang N, Welty-Wolf KE, Choi AM, Piantadosi CA, Serhan CN.
Am J Respir Cell Mol Biol.2015 Sep;53(3):314-25. PMID: 25568926
2014
Glutamate acts as a key signal linking glucose metabolism to incretin/cAMP action to amplify insulin secretion.
Gheni G, Ogura M, Iwasaki M, Yokoi N, Minami K, Nakayama Y, Harada K, Hastoy B, Wu X, Takahashi H, Kimura K, Matsubara T, Hoshikawa R, Hatano N, Sugawara K, Shibasaki T, Inagaki N, Bamba T, Mizoguchi A, Fukusaki E, Rorsman P, Seino S.
Cell Rep. 2014 Oct 23;9(2):661-73. PMID: 25373904
Cell-Cell Interactions and Bronchoconstrictor Eicosanoid Reduction With Inhaled Carbon Monoxide and Resolvin D1.
Shinohara M, Kibi M, Riley IR, Chiang N, Dalli J, Kraft BD, Piantadosi CA, Choi AM, Serhan CN.
Am J Physiol Lung Cell Mol Physiol. 2014 Nov 15;307(10):L746-57 PMID: 25217660
Aging Delays Resolution of Acute Inflammation in Mice: Reprogramming the Host Response with Novel Nanoproresolving Medicines.
Arnardottir HH, Dalli J, Colas RA, Shinohara M, Serhan CN.
J Immunol 2014 Oct 15;193(8):4235-44 PMID: 25217168
Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue.
Colas RA, Shinohara M, Dalli J, Chiang N, Serhan CN.
Am J Physiol Cell Physiol. 2014 Jul 1;307(1):C39-54. PMID: 24696140
2013
Inhaled carbon monoxide accelerates resolution of inflammation via unique proresolving mediator-heme oxygenase-1 circuits.
Chiang N, Shinohara M, Dalli J, Mirakaj V, Kibi M, Choi AM, Serhan CN.
J Immunol. 2013 Jun 15;190(12):6378-88. PMID: 23650615
2012
Role of Phosphatidylinositol 3,4,5-trisphosphate (PIP3) 5-phosphatase, skeletal muscle and kidney enriched inositol polyphosphate phosphatase (SKIP) in myoblast differentiation.
Ijuin T, Takenawa T.
J Biol Chem. 2012 Jul 19. PMID: 22815484
Regulation of Insulin Signaling by the Phosphatidylinositol 3,4,5-Triphosphate Phosphatase SKIP through the Scaffolding Function of Pak1.
Ijuin T, Takenawa T.
Mol Cell Biol. 2012 Sep;32(17):3570-84.
PMID: 22751929
Quantification and visualization of phosphoinositides by quantum dot-labeled specific binding-domain probes.
Irino Y, Tokuda E, Hasegawa J, Itoh T, Takenawa T.
J Lipid Res. 2012 Apr;53(4):810-9.
PMID: 22308508
Regulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP).
Ijuin T, Takenawa T.
J Biol Chem. 2012 Mar 2;287(10):6991-9. Epub 2012 Jan 15. PMID: 22247557
2011
SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain.
Hasegawa J, Tokuda E, Tenno T, Tsujita K, Sawai H, Hiroaki H, Takenawa T, Itoh T.
J Cell Biol. 2011 May 30;193(5):901-16.PMID: 21624956
2010
WASP and WAVE family proteins: friends or foes in cancer invasion?
Kurisu S, Takenawa T.
Cancer Sci. 2010 Oct;101(10):2093-104. Review. PMID: 20707804
Phosphoinositide-binding interface proteins involved in shaping cell membranes.
Takenawa T.
Proc Jpn Acad Ser B Phys Biol Sci. 2010;86(5):509-23. Review. PMID: 20467216
Proteome of acidic phospholipid-binding proteins: spatial and temporal regulation of Coronin 1A by phosphoinositides.
Tsujita K, Itoh T, Kondo A, Oyama M, Kozuka-Hata H, Irino Y, Hasegawa J, Takenawa T.
J Biol Chem. 2010 Feb 26;285(9):6781-9. Epub 2009 Dec 22. PMID: 20032464
2009
The tyrosine kinase Fer is a downstream target of the PLD-PA pathway that regulates cell migration.
Itoh T, Hasegawa J, Tsujita K, Kanaho Y, Takenawa T.
Sci Signal. 2009 Sep 8;2(87):ra52. PMID: 19738202
The WASP and WAVE family proteins.
Kurisu S, Takenawa T.
Genome Biol. 2009;10(6):226. Epub 2009 Jun 15. Review. PMID: 19589182
Mechanisms of membrane deformation by lipid-binding domains.
Itoh T, Takenawa T.
Prog Lipid Res. 2009 Sep;48(5):298-305. Epub 2009 May 27. Review. PMID: 19481110
PtdIns(3,4)P2 instigates focal adhesions to generate podosomes.
Oikawa T, Takenawa T.
Cell Adh Migr. 2009 Apr-Jun;3(2):195-7. Epub 2009 Apr 29. Review. PMID: 19262173
Involvement of Rac and Rho signaling in cancer cell motility in 3D substrates.
Yamazaki D, Kurisu S, Takenawa T.
Oncogene. 2009 Apr 2;28(13):1570-83. Epub 2009 Feb 23. PMID: 19234490
2008
Sequential signals toward podosome formation in NIH-src cells.
Oikawa T, Itoh T, Takenawa T.
J Cell Biol. 2008 Jul 14;182(1):157-69. Epub 2008 Jul 7. PMID: 18606851
Increased insulin action in SKIP heterozygous knockout mice.
Ijuin T, Yu YE, Mizutani K, Pao A, Tateya S, Tamori Y, Bradley A, Takenawa T.
Mol Cell Biol. 2008 Sep;28(17):5184-95. Epub 2008 Jun 23. PMID: 18573875
2007
Casein kinase 2-interacting protein-1, a novel Akt pleckstrin homology domain-interacting protein, down-regulates PI3K/Akt signaling and suppresses tumor growth in vivo.
Tokuda E, Fujita N, Oh-hara T, Sato S, Kurata A, Katayama R, Itoh T, Takenawa T, Miyazono K, Tsuruo T.
Cancer Res. 2007 Oct 15;67(20):9666-76. PMID: 17942896
The WASP-WAVE protein network: connecting the membrane to the cytoskeleton.
Takenawa T, Suetsugu S.
Nat Rev Mol Cell Biol. 2007 Jan;8(1):37-48. Review. PMID: 17183359
