主要論文一覧(R７度)

センターメンバーにはアンダーライン

難治性がん　Intractable Cancers

• DA-Raf synergistically binds to the plasma membrane and Ras to suppress ERK signaling 　Kazunori Takano, Kazuya Tsujita, Akiko Suganami, Takuhiko Nakamura, Emiri Kanno, Yutaka Tamura, Toshiki Itoh, Takeshi Endo.　Life Sci. Alliance. 2025 Dec.8(12). DOI: 10.26508/lsa.202503300 PMID: 41120211
• Role of membrane proximal actin regulators in SARS-CoV-2 spike-induced cell-cell fusion 　Linting Kou, Yumeng Wan, Yuri L. Nemoto, Kazuya Tsujita, Toshiki Itoh Biocheml Biophys Res Commun. 2025 Jun 20: 766 151846. DOI: 10.1016/j.bbrc.2025.151846 PMID: 40300332
• Mechanical control of osteoclast fusion by membrane-cortex attachment and BAR proteins 　Yumeng Wan, Yuri L. Nemoto, Tsukasa Oikawa, Kazunori Takano, Takahiro K. Fujiwara, Kazuya Tsujita, Toshiki Itoh　J Cell Biol. 2025 May: 224(7) DOI: 10.1083/jcb.202411024 PMID: 40338171
• BST2 promotes esophageal squamous cell carcinoma progression by mediating the cell-cell interaction between cancer cells and cancer-associated fibroblasts 　Rikuya Torigoe, Yu-Ichiro Koma, Naozane Nomura, Hiroki Yokoo, Masaki Omori, Takashi Nakanishi, Shoji Miyako, Takaaki Nakanishi, Takayuki Kodama, Manabu Shigeoka, Yoshihiro Kakeji, Masafumi Horie　Am J Pathol. 2026 Feb:196(5)1220-1243. DOI: 10.1016/j.ajpath.2026.01.012 PMID: 41763536
• BGN Secreted by Cancer-Associated Fibroblasts Promotes Esophageal Squamous Cell Carcinoma Progression via Activation of TLR4-Mediated Erk and NF-κB Signaling Pathways 　Hiroki Yokoo, Yu-Ichiro Koma, Naozane Nomura, Rikuya Torigoe, Masaki Omori, Takashi Nakanishi, Shoji Miyako, Takaaki Nakanishi, Takayuki Kodama, Manabu Shigeoka, Yoshihiro Kakeji, Masafumi Horie　Int J Mol Sci. 2025 Dec 26(24)12024. DOI: 10.3390/ijms262412024 PMID: 41465449
• Integrative epigenome and transcriptome analyses reveal transcriptional programs differentially regulated by ASCL1 and NEUROD1 in small cell lung cancer　Hiroshi Takumida, Akira Saito, Yugo Okabe, Yasuhiro Terasaki, Yu Mikami, Hidenori Tanaka, Masami Suzuki, Yu Hamaguchi, Chao Zeng, Michiaki Hamada, Hiroshi I Suzuki, Hidenori Kage, Masafumi Horie　Oncogene. 2025 Jul: 44(34):3113-3125 DOI: 10.1038/s41388-025-03481-2 PMID: 40595415
• Neoadjuvant FOLFOXIRI plus bevacizumab without radiotherapy for high-risk rectal cancer: multicentre phase II trial　Takeru Matsuda, Yoshiaki Nagatani, Yohei Funakoshi, Takahiro Tsuboyama, Yasuhiko Mii, Kunihiko Kaneda, Tomohiro Tanaka, Hiroshi Hasegawa, Kimihiro Yamashita, Naomi Kiyota, Hironobu Minami, Yoshihiro Kakeji　BJS Open. 2025 Dec 10(1):zraf163. DOI: 10.1093/bjsopen/zraf163 PMID: 41661200
• Comparative study of the short-term outcomes of gastric cancer surgery between Japanese Gastric cancer association-certified and non-certified institutions: a retrospective cohort analysis using a national database in Japan　Tomoyuki Matsunaga, Hideki Endo, Hiroyuki Yamamoto, Koshi Kumagai, Shingo Kanaji, Hisato Kawakami, Chika Kusano, Ryoji Kushima, Mitsuhiro Fujishiro, Kensei Yamaguchi, Takaki Yoshikawa, Yuichiro Doki, Yoshihiro Kakeji, Yoshiyuki Fujiwara　Gastric Cancer. 2026 Mar: 29(2)415-423. DOI: 10.1007/s10120-025-01694-8 PMID: 41483151
• Beyond tumor mutational burden: a framework for immune-checkpoint blockade responsiveness in gastrointestinal cancers　Kimihiro Yamashita, Mitsugu Fujita, Masafumi Saito, Junko Mukohyama, Kumiko Miyashita, Taro Ikeda, Yasufumi Kostrzewa, Tomoaki Aoki, Hitoshi Harada, Yasunori Otowa, Naoki Urakawa, Hironobu Goto, Hiroshi Hasegawa, Shingo Kanaji, Takeru Matsuda, Yoshihiro Kakeji　Int J Clin Oncol. 2026 Mar DOI: 10.1007/s10147-026-02997-1 PMID: 41784875

代謝　Metabolism

• Structural analysis of a motor with increased mechanical output reveals new transitions in kinesin microtubule motility　Satoki Shibata, Matthew Y Wang, Tsuyoshi Imasaki, Hideki Shigematsu, Diego Ugarte La Torre, Yuanyuan Wei, Chacko Jobichen, Hajime Hagio, J Sivaraman, Yuji Sugita, Sharyn A Endow, Ryo Nitta　Sci Rep. 2026 Jan: 16(1)487. DOI: 10.1038/s41598-025-28573-7 PMID: 41491787
• Human spastin functions as an ATPase-independent microtubule nucleator via ring-stack formation　Hanjin Liu, Nao Matsumoto, Toshiyuki Kaneshiro, Takaaki Kato, Hideki Shigematsu, Satoshi Kikkawa, Eriko Nitta, Tsuyoshi Imasaki, Ryo Nitta　bioRxiv 2025 Nov. DOI: 10.1101/2025.11.28.691112
• Cryo-ET of actin cytoskeleton and membrane structure in lamellipodia formation using optogenetics　Hironori Inaba, Tsuyoshi Imasaki, Kazuhiro Aoyama, Shogo Yoshihara, Hiroko Takazaki, Takayuki Kato, Hidemasa Goto, Kaoru Mitsuoka, Ryo Nitta, Takao Nakata　iScience. 2025 Jun: 28(6):112529. DOI: 10.1016/j.isci.2025.112529 PMID: 40475257
• ADP ribosylation factor-like GTPase 6-interacting protein 5 (ARL6IP5): a prenylated Rab acceptor protein 1 (PRA1) family protein that shapes the ER membrane and regulates ER-phagy　Yasunori Yamamoto, Toshiaki Sakisaka　Autophagy Rep. 2025 Jun: 4(1):2513466. DOI: 10.1080/27694127.2025.2513466 PMID: 40503170
• ADP ribosylation factor–like GTPase 6–interacting protein 5 (Arl6IP5) is an ER membrane-shaping protein that modulates ER-phagy　Yasunori Yamamoto, Toshiaki Sakisaka　J Biol Chem. 2025 May: 301(5)108493. DOI: 10.1016/j.jbc.2025.108493 PMID: 40209949
• High-Fat Diet-Fed Kcnq1 Mutant Mice Have Reduced Pancreatic β-Cell Mass via Gene-Environment Interaction. 　Shun-Ichiro Asahara, Hiroyuki Inoue, Yuka Ihara, Kyoko Teruyama, Asuka Imai, Chisako Hara, Mizuki Hara, Masako Seike, Aisha Yokoi, Nozomi Kido, Hirotaka Suzuki, Ayumi Kanno, Yuka Inaba, Hitoshi Watanabe, Go Shioi, Maki Kimura-Koyanagi, Michihiro Matsumoto, Hiroshi Inoue, Keiichi I Nakayama, Wataru Ogawa, Masato Kasuga, Yoshiaki Kido. 　Diabetes Metab J. Epub 2025 Jul DOI: 10.4093/dmj.2024.0790 PMID: 40734497
• The usefulness of HbA1c measurement in diabetic mouse models using various devices　Koya Miyazaki, Aisha Yokoi, Hiroyuki Inoue, Hirotaka Suzuki, Nozomi Kido, Ayumi Kanno, Maki Kimura-Koyanagi, Yoshiaki Kido, Shun-Ichiro Asahara　Exp Anim. 2025 Jul: 74(3)319-327. DOI: 10.1538/expanim.24-0154 PMID: 39880619
• Impaired cardiac branched-chain amino acid metabolism in a novel model of diabetic cardiomyopathy　Junko Asakura, Manabu Nagao, Masakazu Shinohara, Tetsuya Hosooka, Naoya Kuwahara, Makoto Nishimori, Hidekazu Tanaka, Seimi Satomi-Kobayashi, Sho Matsui, Tsutomu Sasaki, Tadahiro Kitamura, Hiromasa Otake, Tatsuro Ishida, Wataru Ogawa, Ken-Ichi Hirata, Ryuji Toh　Cardiovasc Diabetol. 2025 Apr: 24(1)267. DOI: 10.1186/s12933-025-02725-5 PMID: 40240904
• Interleukin-6 Enhances Localized Immune Cell Infiltration and Deep Vein Thrombosis Resolution at the Distal Edge　Arinal Chairul Achyar, Tetsuya Hara, Aditya Adinata, Yoko Suzuki, Makoto Nishimori, Ken-Ichi Hirata, Hiromasa Otake, Noriaki Emoto　Am J Physiol Heart Circ Physiol. 2025 Aug 1:329(2)H603-H621. DOI: 10.1152/ajpheart.00163.2025 PMID: 40695538 Epub Jul 22

脳こころ　Brain and Mind

• Sex differences in the risk of autistic-related traits in toddlers born to mothers with perinatal depression: Evidence from human cohort and mouse study　Changrong Duan, Zhiqian Yu, Xue Li, Mai Sakai, Yuko Maejima, Kenju Shimomura, Tomoyuki Furuyashiki, Saya Kikuchi, Natsuko Kobayashi, Kazuto Sasaki, Tasuku Matsuki, Hiroshi Komatsu, Mizuki Hino, Yasuto Kunii, Tomoko Kasahara, Mami Ishikuro, Keiko Murakami, Masatsugu Orui, Takaaki Abe, Fuji Nagami, Nobuo Fuse, Soichi Ogishima, Kengo Kinoshita, Masayuki Yamamoto, Naoki Nakaya, Atsushi Hozawa, Taku Obara, Shinichi Kuriyama, Hiroaki Tomita　Mol Psychiatry. Epub 2026 Feb 4. DOI: 10.1038/s41380-026-03456-z PMID: 41639232
• Protective Role of Apelin in a Mouse Model of Post-Intensive Care Syndrome　Yumiko Imai, Yasuha Kinugasa, Ryota Nukiwa, Mara Anais Llamas Covarrubias, Khin Kyaemon Thwin, Kumiko Yonezaki, Takashi Shimizu, Sho Yamasaki, Yusuke Shintani, Hitoshi Hashimoto, Yutaka Suzuki, Yuji Fujino, Kota Kubodera, Toru Kotani, Tomoyuki Furuyashiki, Josef Penninger, Arthur S Slutsky　Am J Respir Cell Mol Biol. 2026 Feb 1:74(2):241-256. DOI: 10.1165/rcmb.2025-0028OC PMID: 40920972
• Recovery of centralities in medial prefrontal and sensory-related cortices associated with social behavior improvements in an autism mouse model　Hiroki Ueno, Yusuke Iyanaga, Katsuyuki Kunida, Yuta Hara, Hiroki Miura, Yuka Nakai, Masato Tanuma, Misuzu Hayashida, Rei Yokoyama, Jin Ohkubo, Kaoru Seiriki, Atsuko Hayata-Takano, Tomoka Ao, Shun Yamaguchi, Shiho Kitaoka, Tomoyuki Furuyashiki, Yukio Ago, Takanobu Nakazawa, Kazuhiro Takuma, Junichiro Yoshimoto, Hitoshi Hashimoto, Atsushi Kasai　Sci Reps. 2025 Jul 2: 15:22895. DOI: 10.1038/s41598-025-05996-w PMID: 40594719
• Isogenic modeling of 1q21.1 reciprocal CNVs in human ES cells reveals divergent neurodevelopmental trajectories　Yoshiko Nomura, Jun Nomura, Kota Tamada, Noriomi Eguchi, Kosuke Torigata, Shoichi Tokumoto, Akisa Nemoto, Toshihiko Shirafuji, Kana Yamamoto, Akitoyo Hishimoto, Hiroaki Nagase, Toru Nishikawa, Toru Takumi　Hum Mol Genet. 2026 Feb 9: 35 (2). DOI: 10.1093/hmg/ddaf184 PMID: 41370233
• Parvalbumin interneurons in the insular cortex control social familiarity and emotion recognition　Shuhei Fujima, Masaaki Sato, Nobuhiro Nakai, Toru Takumi　Cell Rep. 2025 Sep 23:44(9):116085. DOI: 10.1016/j.celrep.2025.116085 PMID: 40865515 Epub 2025 Aug 26
• ESC models of autism with copy-number variations reveal cell-type-specific translational vulnerability　Jun Nomura, Amila Zuko, Keiko Kishimoto, Hiroaki Mutsumine, Hiroko Maegawa, Kazumi Fukatsu, Yoshiko Nomura, Xiaoxi Liu, Nobuhiro Nakai, Eiki Takahashi, Tsukasa Kouno, Jay W Shin, Toru Takumi　Cell Genom. 2025 Jun 11: 5(6)100877. DOI: 10.1016/j.xgen.2025.100877 PMID: 40505628
• Nox3 expression and function in retinal ganglion cells and amacrine cells　Takehiko Ueyama, Kyoko Yamaguchi, Yakumo Aoyama, Kota Aoshima, Michiho Onizuka, Taichi Tamagawa, Shota Kitayama, Junichi Ueyama, Kiyoki Okamoto, Hiroaki Mohri, Masamitsu Shimazawa　Cell Mol Life Sci. 2025 Dec 3; 83(1):28. DOI: 10.1007/s00018-025-05876-6 PMID: 41339603
• Age-Progressive Synaptic and Axonal Dysregulation Induced by Purkinje Cell-Targeted AAV Expression of SCA14 PKCγ in Mice　Naoko Adachi, Izumi Koganemaru, Feng Wanying, Naoya Matsushita, Tomoyoshi Nakayama, Takahiro Seki, Ayumu Konno, Hirokazu Hirai, Naoaki Saito, Takehiko Ueyama　J Neurochem. 2025 Nov; 169(11)e70305. DOI: 10.1111/jnc.70305 PMID: 41287930
• Localization of Puncta Adherentia Junctions at GABAergic Synapses on Parvalbumin-Positive GABAergic Inhibitory Neurons in the Mouse Hippocampus　Kimitaka Katanazaka, Hajime Shiotani, Muneaki Miyata, Takeshi Kameyama, Shin Kedashiro, Ryouhei Komaki, Shota Nishii, Yutaro Kashiwagi, Yuka Sato, Shigeo Okabe, Norio Chihara, Riki Matsumoto, Kiyohito Mizutani, Yoshimi Takai.　J Comp Neurol. 2026 Mar: 534(3)e70152. DOI: 10.1002/cne.70152 PMID: 41854227
• Characteristic patterns of complement deposition in NMOSD, MOGAD, and MS　Yoshiki Takai, Simon Hametner, Christian Riedl, Tatsuro Misu, Toshiyuki Takahashi, Hiroyoshi Suzuki, Norio Chihara, Masashi Watanabe, Hiroaki Miyahara, Mari Yoshida, Yasushi Iwasaki, Takashi Suzuki, Franziska Di Pauli, Stephan Bramow, Guy Laureys, Brenda Banwell, Sara Mariotto, Kazuo Fujihara, Masashi Aoki, Monika Bradl, Hans Lassmann, Romana Höftberger　Acta Neuropathol. 2026 Feb 9:151(1)13. DOI: 10.1007/s00401-026-02985-9 PMID: 41661329
• Necl-4/CADM4 regulates GABAergic synaptic strength on GABAergic inhibitory neurons via ErbB4 activation and prevents neuronal impairments　Ryouhei Komaki, Hajime Shiotani, Toshihiko Kuriu, Takeshi Kameyama, Muneaki Miyata, Shin Kedashiro, Kimitaka Katanazaka, Shota Nishii, Norio Chihara, Riki Matsumoto, Michinori Koebis, Atsu Aiba, Kiyohito Mizutani, Yoshimi Takai.　Mol Neurobiol. 2025 Dec: 62(12):15943-15968. DOI: 10.1007/s12035-025-05230-8 PMID: 40728771 Epub 2025 Jul 29

免疫・感染症　Immunology & Infectious Disease

• Defining and Predicting HIV Immunological Non-Response: A Multi-Definition Analysis from an Indonesian Cohort　Brian Eka Rachman, Yehuda Tri Nugroho Supranoto, Soraya Isfandiary Iskandar, Tri Pudy Asmarawati, Siti Qamariyah Khairunisa, Muhammad Vitanata Arfijanto, Usman Hadi, Muhammad Miftahussurur, Nasronudin Nasronudin, Masanori Kameoka, Retno Pudji Rahayu, Afif Nurul Hidayati　Viruses. 2025 Dec:17(2)1581. DOI: 10.3390/v17121581
• Antimicrobial and antiviral activities and reaction mechanisms of an organic photocatalyst upon visible-light irradiation　Hayato Shiroma, Atsushi Chikamoto, Masanori Kameoka, Kazuo Kumagai, Hideto Matsuyama, Yuichi Ichihashi　Res. Chem. Intermed. 2025 Aprl: 51; 2591-2604. DOI: 10.1007/s11164-025-05570-z
• Microbial Dysbiosis and Foot Odor in Nagashima-Type Palmoplantar Keratosis: Improvement with Topical Benzoyl Peroxide　Noriko Ono, Yoshihiro Ito, Satomi Aoki, Aiko Shiohama, Takashi Sasaki, Rina Kurokawa, Wataru Suda, Masayuki Amagai, Akiharu Kubo　J Invest Dermatol. Epub 2025 DOI: 10.1016/j.jid.2025.11.011 PMID: 41338335
• Rho-ROCK liberates sequestered claudin for rapid de novo tight junction formation　Yuma Cho, Akari Taniguchi, Akiharu Kubo, Junichi Ikenouchi　eLife. 2025 Jul: 13: RP102794. DOI: 10.7554/eLife.102794.3 PMID: 40705412
• Aquaporin 3 inhibition attenuates imiquimod-induced psoriatic symptoms in a murine model　Ryosuke Okubo, Manami Tanaka, Akiharu Kubo, Masato Yasui, Mariko Hara-Chikuma　Mol Biol Rep. 2025 Apr 1: 52(1)354. DOI: 10.1007/s11033-025-10444-z PMID: 40167833
• Clinical manifestations of immunoglobulin G4-related gastrointestinal disease: a nationwide multicenter retrospective study　Atsuhiro Masuda, Kenji Notohara, Yuzo Kodama, Dai Inoue, Takeji Umemura, Tsukasa Ikeura, Atsushi Kanno, Eisuke Iwasaki, Nao Fujimori, Hiroshi Seno, Kazuhiro Kikuta, Hiroshi Nakase, Takeshi Uehara, Shohei Abe, Masahiro Tsujimae, Seiji Nakamura, Mitsuhiro Kawano, Atsushi Masamune　J Gastroenterol. 2026 Jan: 61(1);16-26. DOI: 10.1007/s00535-025-02307-y PMID: 41148248
• Peripancreatic Vascular Involvement and Gastric Varices in Autoimmune Pancreatitis: A Multicenter Retrospective Study　Noriko Juri, Atsuhiro Masuda, Ryota Nakano, Takao Kato, Yuichi Hirata, Koichi Fujita, Shigeto Ashina, Megumi Takagi, Hirofumi Ogawa, Takashi Nakagawa, Seiji Fujigaki, Kyohei Ogisu, Takao Iemoto, Takeshi Ezaki, Yosuke Yagi, Kodai Yamanaka, Takuya Ikegawa, Yu Sato, Keisuke Furumatsu, Masahiro Tsujimae, Arata Sakai, Takashi Kobayashi, Hideyuki Shiomi, Tsuyoshi Sanuki, Yoshifumi Arisaka, Yoshihiro Okabe, Eisuke Ueshima, Keitaro Sofue, Norimitsu Uza, Yuzo Kodama　Clin Gastroenterol Hepatol Epub 2025 Aug: DOI: 10.1016/j.cgh.2025.06.044 PMID: 40774591
• Selective identification of polyploid hepatocellular carcinomas with poor prognosis by artificial intelligence-based pathological image recognition　Takanori Matsuura, Masatoshi Abe, Yoshiyuki Harada, Masahiro Kido, Hajime Nagahara, Yuzo Kodama, Yoshihide Ueda, Eiji Hara, Hirohiko Niioka, Tomonori Matsumoto　Commun Med. 2025 Jul 3; 5(1):270. DOI: 10.1038/s43856-025-00967-8 PMID: 40610763
• Mosquito populations originating from nonendemic areas have the potential to transmit recently emerging Japanese encephalitis virus genotype IV　Astri Nur Faizah, Daisuke Kobayashi, Faustus Akankperiwen Azerigyik, Ryo Matsumura, Izumi Kai, Yoshihide Maekawa, Yukiko Higa, Kentaro Itokawa, Toshinori Sasaki, Kris Cahyo Mulyatno, Sri Subekti, Maria Inge Lusida, Etik Ainun Rohmah, Yasuko Mori, Yusuf Ozbel, Chizu Sanjoba, Tran Vu Phong, Tran Cong Tu, Shinji Kasai, Kyoko Sawabe, Haruhiko Isawa　Emerg Microbes Infect. 2025 Dec; 14(1)2438661. DOI: 10.1080/22221751.2024.2438661 PMID: 39655411
• Summary of the 12th International Conference on Human Herpesviruses-6A, -6B, and -7　Anthony L Komaroff, Hideo Asada, Masao Ogata, Tetsushi Yoshikawa, Yasuko Mori　J Med Virol. 2025 Sep; 97(9)e70602. DOI: 10.1002/jmv.70602 PMID: 40947653
• Endogenous human herpesviruses 6A/B　Louis Flamand, Jesse Arbuckle, Pascale Bonnafous, Vincent Descamps, Joshua A Hill, Ruth Jarrett, Keith Jerome, Benedikt B Kaufer, Rie Koide, Anthony L Komaroff, Peter Medveczky, Hiroki Miura, Yasuko Mori, Nicholas Parrish, Philip E Pellett, Michael Wood, Tetsushi Yoshikawa, Danielle M Zerr　J Virol. 2025 Sep 23; 99(9):e0105425. DOI: 10.1128/jvi.01054-25 PMID: 40748144 Epub 2025 Aug.
• Rapid diagnosis of ocular viral infections via single-virus detection using solid-state nanopore: A diagnostic evaluation study　Noriyasu Hashida, Hiroyasu Takei, Masateru Taniguchi, Norihiko Naono, Takeshi Soma, Yoshinori Oie, Kazuichi Maruyama, Lidya Handayani, Yasuko Mori, Andrew Quantock, Kohji Nishida　PNAS Nexus. 2025 May 21: 4(6):pgaf161. DOI: 10.1093/pnasnexus/pgaf161 PMID: 40496189 eCollection 2025 Jun.
• Pyruvate-GPR31 axis induces LysoDC dendrite protrusion to M-cell pockets for effective immune responses　Katsuhiro Nakanishi, Takayuki Ajiro, Kaito Yukishima, Yuki Tsukamoto, Junichi Kikuta, Shinichiro Sawa, Michio Tomura, Nozomi Kinoshita, Wataru Shimanuki, Akio Suzuki, Shun Arai, Kazuki Maeshima, Takumi Ichisawa, Tomoya Katakai, Haruko Hayasaka, Masaru Ishii, Eiji Umemoto　Gut Microbes. 2025 Dec; 17(1):2536089. DOI: 10.1080/19490976.2025.2536089 PMID: 40745869
• The RANK/RANKL axis controls vascular dynamics in the bone marrow　Takeshi Kaneko, Shinya Yari, Junichi Kikuta, Yoshiki Omatsu, Shigeto Seno, Sumire Kikuchi, Kazuma Sato, Kentaro Fujii, Takao Sudo, Tetsuo Hasegawa, Kunimaro Furuta, Qianqian Guo, Samar H. Ibrahim, Kosuke Muraoka, Yoshiaki Okada, Yoshiaki Kubota, Daisuke Okuzaki, Yasuhiro Kobayashi, Atsushi Kumanogoh, Nobuyuki Udagawa, Takashi Nagasawa, Josef M. Penninger, Masaru Ishii　Proc Natl Acad Sci U S A. 2025 Nov 11;122(45):e2425366122. DOI: 10.1073/pnas.2425366122 PMID: 41183210
• HCV infection induces ubiquitin-dependent degradation of LATS1, inactivating the Hippo pathway and upregulating transcription of the CYR61 and CTGF genes　Maria Alethea Septianastiti, Chieko Matsui, Zihan Xu, Fransisca Puspitasari, Dewa Nyoman Murti Adyaksa, Lin Deng, Takayuki Abe, Ikuo Shoji　J Gen Virol. 2026 Feb; 107(2):002221. DOI: 10.1099/jgv.0.002221 PMID: 41642640
• Hepatitis C virus NS3/4A protease cleaves SPG20, a key regulator of lipid droplet turnover, to promote lipid droplet formation　Chieko Matsui, Putu Yuliandari, Lin Deng, Takayuki Abe, Ikuo Shoji　J Virol. 2025 Oct 23; 99(10)e0089025. DOI: 10.1128/jvi.00890-25 PMID: 40985721 Epub 2025 Sep 23
• A novel synthetic bile acid derivative inhibits hepatitis B virus infection at entry step by interfering with the oligomerization of sodium taurocholate co-transporting polypeptide　Gede Ngurah Rsi Suwardana, Takayuki Abe, Lin Deng, Chieko Matsui, Takashi Okitsu, Takeshi Yamada, Manabu Hatano, Pattama Wiriyasermkul, Shushi Nagamori, Sameh A Gad, Hussein H Aly, Hironori Nishitsuji, Kunitada Shimotohno, Ikuo Shoji　Antiviral Res. 2025 Nov; 243:106267. DOI: 10.1016/j.antiviral.2025.106267 PMID: 40889532 Epub 2025 Aug 30
• Rituximab-induced long-term remission in childhood-onset, uncomplicated, frequently relapsing or steroid-dependent nephrotic syndrome: a randomized, placebo-controlled trial and a follow-up study　Kazumoto Iijima, Mayumi Sako, Tomoko Horinouchi, Tomoyuki Sakai, Tomohiko Yamamura, Riku Hamada, Yasufumi Ohtsuka, Seiji Tanaka, Koichi Kamei, Ryojiro Tanaka, Yuji Kano, Takuo Kubota, Yuko Shima, Tamaki Morohashi, Aya Inaba, Shuichiro Fujinaga, Masafumi Oka, Hiroshi Kaito, Akihide Konishi, China Nagano, Koichi Nakanishi, Kenji Ishikura, Shuichi Ito, Hidefumi Nakamura, Gian Marco Ghiggeri, Rintaro Mori, Takashi Omori, Kandai Nozu　Sci Rep. 2025 Oct 10; 15(1):34306. DOI: 10.1038/s41598-025-19214-0 PMID: 41073503
• Exon Skipping Therapies for Rare Kidney Diseases　Tomohiko Yamamura, Kandai Nozu　. J Am Soc Nephrol : JASN. 2025 May 1; 36(5);967-969. DOI: 10.1681/ASN.0000000623 PMID: 39774852
• Comprehensive Splice Pattern Analysis for Previously Reported OCRL Splicing Variants and Their Phenotypic Contributions　Rini Rossanti, Eri Okada, Nana Sakakibara, Ryota Suzuki, Yuta Inoki, Yuta Ichikawa, Yu Tanaka, Hideaki Kitakado, Chika Ueda, Atsushi Kondo, Yuya Aoto, China Nagano, Tomoko Horinouchi, Tomohiko Yamamura, Shingo Ishimori, Kandai Nozu　Kidney Int Rep. eCollection 2025 May: 10(5)(5)1509-1517. DOI: 10.1016/j.ekir.2025.02.023 PMID: 40485688

再生医学　Regenerative Medicine

• Alteration of long- and short-term hematopoietic stem cell ratio causes myeloid-biased hematopoiesis　Katsuyuki Nishi, Taro Sakamaki, Akiomi Nagasaka, Kevin Shuolong Kao, Kay Sadaoka, Masahide Asano, Nobuyuki Yamamoto, Akifumi Takaori-Kondo, Masanori Miyanishi　eLife. 2025 Aug 27; 13:RP95880. DOI: 10.7554/eLife.95880 PMID: 40864176
• Ready-to-use cryopreservation of undifferentiated induced pluripotent stem cells (iPSCs) without detachment from culture plates using D-proline and a synthetic polymer　Kenta Morita, Shinya Kawasaki, Tomoko Yashiro, Ryoko Futai, Chanhyon Kin, Aito Nakahashi, Hikaru Amo, Yukiya Kitayama, Takashi Aoi, Michiyo Koyanagi-Aoi, Tatsuo Maruyama　Biochem. Eng. J. 2026 Mar; 227:110041. DOI: 10.1016/j.bej.2025.110041
• Prediction of the hypothalamus-pituitary organoid formation using machine learning　Ryusaku Matsumoto, Hidetaka Suga, Yutaka Takahashi, Takashi Aoi, Takuya Yamamoto　Cell Rep Methods. 2025 Aug 18; 5(8): 101119. DOI: 10.1016/j.crmeth.2025.101119 PMID: 40763741
• Regulation of MCCC1 expression by a Parkinson's disease-associated intronic variant: implications for pathogenesis　Shunsaku Sogabe, Hiroko Nakano, Yusuke Ogasahara, Pei-Chieng Cha, Yuko Ando, Mariko Taniguchi-Ikeda, Ryusaku Matsumoto, Motoi Kanagawa, Kazuhiro Kobayashi, Shigeo Murayama, Takashi Aoi, Tatsushi Toda, Wataru Satake　J Hum Genet. 2025 Jul; 70(7);371-374. DOI: 10.1038/s10038-025-01335-z PMID: 40216992
• Relationships between frailty and surgical outcomes of palliative surgery for spinal metastases : a prospective cohort study　Takeru Tsujimoto, Tomoya Matsuo, Takashi Yurube, Yoshiki Takeoka, Yutaro Kanda, Ryosuke Kuroda, Kenichiro Kakutani　Bone Jt Open. 2025 Oct 7; 6(10);1199-1207. DOI: 10.1302/2633-1462.610.BJO-2024-0253.R1 PMID: 41052775
• Potential of boron neutron capture therapy (BNCT) for epithelioid sarcoma　Takuya Fujimoto, Tooru Andoh, Tamotsu Sudo, Toshiko Sakuma, Ikuo Fujita, Yoshinori Sakurai, Takushi Takata, Hiroki Tanaka, Teruya Kawamoto, Shunsuke Yahiro, Hitomi Hara, Naomasa Fukase, Toshihiro Akisue, Hideki Ichikawa, Ryosuke Kuroda, Minoru Suzuki　Appl Radiat Isot. 2025 Aug; 222;111846. DOI: 10.1016/j.apradiso.2025.111846 PMID: 40319847
• Risk Factors for Wound Dehiscence After Spinal Metastasis Surgery and a New Approach to Prevention-Curved Skin Incision　Kunihiko Miyazaki, Yutaro Kanda, Takashi Yurube, Yoshiki Takeoka, Takeru Tsujimoto, Tomoya Matsuo, Masao Ryu, Naotoshi Kumagai, Kohei Kuroshima, Yoshiaki Hiranaka, Ryosuke Kuroda, Kenichiro Kakutani　Cancers. 2025 Jun 13; 17(12); 1973. DOI: 10.3390/cancers17121973 PMID: 40563623
• External Nasal Reconstruction in Patients With Extranodal Natural Killer (NK)/T-cell Lymphoma, Nasal Type　Misato Ueda, Tadashi Nomura, Shunsuke Sakakibara　Cureus. 2025 Dec 20; 17(12): e99730-. DOI: 10.7759/cureus.99730 PMID: 41561241

創薬・医療機器　New Drug & Medical Device Development

• Plasma expression levels of microRNA-101 are downregulated in patients with Parkinson's disease　Tomohiro Omura, Hiroki Nishiguchi, Haruka Kaneda, Yumi Kitahiro, Kotaro Itohara, Kazuhiro Yamamoto, Toshiyasu Sakane, Ikuko Yano　BMC Res Notes. 2025 Dec 10; 19(1):19. DOI: 10.1186/s13104-025-07604-6 PMID: 41373032
• Evaluation of Fentanyl-Emerged Adverse Events and Pharmacokinetics in Neonates: A Physiologically Based Pharmacokinetic Modeling Approach　Walaa Yousef Bassyouni Mahdy, Kazuhiro Yamamoto, Risa Joji, Mari Hashimoto, Ruka Nakasone, Kazumichi Fujioka, Kotaro Itohara, Yumi Kitahiro, Tomohiro Omura, Ikuko Yano　Clin Pharmacokinet. 2025 Dec; 64(12):1811-1825. DOI: 10.1007/s40262-025-01573-6 PMID: 40999188 Epub 2025 Se- 26.
• A Newly Launched Nationwide Database Revealed Real-World Evidence on Systemic Therapy for Unresectable Hepatocellular Carcinoma in Japan: Hepatoma Registry of Integrating and Aggregating Electronic Health Record (HERITAGE)　Yoshinari Asaoka, Ryosuke Tateishi, Yasuhide Yamada, Takashi Kokudo, Akiko Saito, Kiyoshi Hasegawa, Hiroko Iijima, Naoya Kato, Mitsuo Shimada, Etsuro Hatano, Takumi Fukumoto, Takamichi Murakami, Hirohisa Yano, Kengo Yoshimitsu, Masayuki Kurosaki, Michiie Sakamoto, Yutaka Matsuyama, Masatoshi Kudo, Hiroaki Miyata, Norihiro Kokudo　Liver Cancer. 2025 Jun 22; 15(1):77-89. DOI: 10.1159/000546862 PMID: 40747339
• Gadoxetic Acid-Enhanced Magnetic Resonance Imaging Features Can Predict Immune-Excluded Phenotype of Hepatocellular Carcinoma　Eisuke Ueshima, Keitaro Sofue, Takahiro Kodama, Shuhei Yamamoto, Masato Komatsu, Shohei Komatsu, Nobuaki Ishihara, Akihiro Umeno, Takeru Yamaguchi, Masatoshi Hori, Takumi Fukumoto, Tetsuo Takehara, Takamichi Murakami　Liver Cancer. eCollection 2025 Jun; 14(3):271-285. DOI: 10.1159/000542099 PMID: 40547958

AI・デジタルヘルス　AI･Digital Health

• Evaluation of control strategies for robot-assisted multi-bending endoscope system (RAMBES)　Kosuke Yokoyama, Ryu Nakadate, Toshitatsu Takao, Yoshinori Morita, Norihito Wada, Yoshihiro Muragaki　Surg Endosc. 2025 Oct; 39(10):6496-6503. DOI: 10.1007/s00464-025-12023-6 PMID: 40789773

代謝 × 創薬・医療機器

• Dimerization of GAS2 mediates crosslinking of microtubules and F-actin　Jiancheng An, Tsuyoshi Imasaki, Akihiro Narita, Shinsuke Niwa, Ryohei Sasaki, Tsukasa Makino, Ryo Nitta, Masahide Kikkawa　EMBO J. 2025 May:33(10)2997-3024. DOI: 10.1038/s44318-025-00415-2 PMID: 40169809 Epub 2025 Apr. 1

免疫・感染症 × 創薬・医療機器

• Prognosis of Hepatectomy versus Systemic Chemotherapy Based on Oncological Resectability Criteria for Borderline Resectable Hepatocellular Carcinoma　Shohei Komatsu, Toshifumi Tada, Takashi Nishimura, Motofumi Tanaka, Atsushi Takebe, Saeko Kushida, Yoshimi Fujishima, Nobuaki Ishihara, Takanori Matsuura, Ikuo Nakamura, Taro Okazaki, Masahiro Tsuda, Jun Ishida, Ippei Matsumoto, Seiko Hirono, Hirayuki Enomoto, Yuzo Kodama, Takumi Fukumoto　Liver Cancer. 2025 Jun 10; 15(1):38-49. DOI: 10.1159/000546830 PMID: 40636398

脳こころ × AI・デジタルヘルス

• Soft-voting classifier for outcome prediction in traumatic brain injury patients with clear consciousness: model development and error pattern analysis　Kazuya Matsuo, Hideo Aihara, Yoshie Hara, Akitsugu Morishita, Yoshio Sakagami, Shigeru Miyake, Shotaro Tatsumi, Haruo Yamashita, Takashi Sasayama, Yoshihiro Muragaki　Neurosurg Rev. 2025 Dec 22; 49(1):86. DOI: 10.1007/s10143-025-04022-x PMID: 41423515

創薬・医療機器 × AI・デジタルヘルス

• Toward safe clinical deployment of remote robotic surgery in Japan: five-year validation of the hinotoriTM system using 5G wireless communication　Takuto Hara, Yoshifumi Morihiro, Yuki Horise, Shuhei Komatsu, Masanao Ohashi, Hiroaki Kitatsuji, Akihisa Yao, Yoshihiro Muragaki, Hideaki Miyake　Int J Clin Oncol. 2025 Dec; 30(12):2389-2398. DOI: 10.1007/s10147-025-02874-3 PMID: 41160299