主要論文一覧(R６度)

センターメンバーにはアンダーライン

難治性がん　Intractable Cancers

• Outcome research on esophagectomy analyzed using nationwide databases in Japan: evidences generated from real-world data.　Yoshihiro Kakeji, Hiroyuki Yamamoto, Masayuki Watanabe, Koji Kono, Hideki Ueno, Yuichiro Doki, Yuko Kitagawa, Hiroya Takeuchi, Ken Shirabe, Yasuyuki Seto.　Esophagus. 2024 Aug :21(4)(4)411-418. DOI: 10.1007/s10388-024-01080-w. PMID: 39158676.
• Periostin in Cancer-Associated Fibroblasts Promotes Esophageal Squamous Cell Carcinoma Progression by Enhancing Cancer and Stromal Cell Migration.　Shoji Miyako, Yu-ichiro Koma, Takashi Nakanishi, Shuichi Tsukamoto, Keitaro Yamanaka, Nobuaki Ishihara, Yuki Azumi, Satoshi Urakami, Masaki Shimizu, Takayuki Kodama, Mari Nishio, Manabu Shigeoka, Yoshihiro Kakeji, Hiroshi Yokozaki.　The American Journal of Pathology. 2024 May :194(5)(5)828-848.DOI: 10.1016/j.ajpath.2023.12.010. PMID: 38320632.
• AREG Upregulation in Cancer Cells via Direct Interaction with Cancer-Associated Fibroblasts Promotes Esophageal Squamous Cell Carcinoma Progression Through EGFR-Erk/p38 MAPK Signaling.　 Takashi Nakanishi, Yu-ichiro Koma, Shoji Miyako, Rikuya Torigoe, Hiroki Yokoo, Masaki Omori, Keitaro Yamanaka, Nobuaki Ishihara, Shuichi Tsukamoto, Takayuki Kodama, Mari Nishio, Manabu Shigeoka, Hiroshi Yokozaki, Yoshihiro Kakeji.　Cells. 2024 Oct :13(20)1733-1733. DOI: 10.3390/cells13201733. PMID: 39451251.
• Skull base surgery for malignant tumors: The 2nd international collaborative study (1995-2015)　Jatin P Shah, Helena Levyn, Cristina Valero, Dauren Adilbay, Alana Eagan, Junting Zheng, Mithat Gonen, Marc Cohen, Snehal Patel, Ian Ganly, Prathamesh Pai, Paolo Castelnuovo Fang Ju Gao, Cesare Piazza, Piero Nicolai, Ben Panizza, James Bowman, Catherine Barnett, Luiz P Kowalski, Ronaldo Toledo, Dan M Fliss, John DeAlmeida, Ian Witterick, Philippe Herman, Walter Fontanella, Gregorio Sanchez Aniceto, Sefik Hosal, Serdar Ozer, Subramania Iyer, Richard Harvey, C Rene Leemans, Jan-Jaap Hendrickx, Marcelo Figari, Luis Boccalatte, Ken-Ichi Nibu, Peter Clarke, Catherine Rennie, Zhu Yi Ming, Claudio Cernea, Sergio Goncalves, Rodney Schlosser, Fernando Dias, Zoukaa Sargi, Shahzada Ahmed, Wojciech Golusinski, Se Heon Kim, Shirley Y Su, Shaan M Raza, Franco DeMonte, Ehab Hanna.　 HEAD NECK. 2024 Nov:46(11)2762-2775-.DOI: 10.1002/hed.27746. PMID: 38770972.
• Human papillomavirus-driven head and neck cancers in Japan during 2008-2009 and 2018-2019: The BROADEN study.　Ken-Ichi Nibu, Nobuhiko Oridate, Yuki Saito, Montserrat Roset, Marta Forés Maresma, Daniel Cuadras, Edith Morais, Craig Roberts, Ya-Ting Chen, Jacque Spitzer, Kayo Sato, Itori Saito, Ichiro Tazaki, Omar Clavero, Lea Schroeder, Laia Alemany, Hisham Mehanna, Haitham Mirghani, Anna R Giuliano, Miquel Angel Pavón, Tim Waterboe.　Cancer Sci. 2024 Aug:115(8)2808-2818-.DOI:10.1111/ cas.16230. PMID: 38847353.
• Induction of Immunological Antitumor Effects by the Combination of Adenovirus-Mediated Gene Transfer of B7-1 and Anti-Programmed Cell Death-1 Antibody in a Murine Squamous Cell Carcinoma Model.　 Makiko Hara, Sumiyo Saburi, Natsumi Uehara, Takahiro Tsujikawa, Mie Kubo, Tatsuya Furukawa, Masanori Teshima, Hirotaka Shinomiya, Shigeru Hirano, Ken-Ichi Nibu.　CANCERS. 2024 :16(7)-.DOI: 10.3390/cancers16071359. PMID: 38611038.
• Role of the Ror family receptors in Wnt5a signaling.　Koki Kamizaki, Yasuhiro Minami, Michiru Nishita.　In Vitro Cell Dev Biol Anim. 2024 May;60(5):489-501. DOI: 10.1007/s11626-024-00885-4. PMID: 38587578.
• Ror2 signaling regulated by differential Wnt proteins determines pathological fate of muscle mesenchymal progenitors.　Koki Kamizaki, Mitsuko Katsukawa, Ayano Yamamoto, So-Ichiro Fukada, Akiyoshi Uezumi, Mitsuharu Endo, Yasuhiro Minami.　 Cell Death Dis. 2024 Oct;15(10)784. DOI: 10.1038/s41419-024-07173-9. PMID: 39468010.
• KIF1C facilitates retrograde transport of lysosomes through Hook3 and dynein.　Takeshi Saji, Mitsuharu Endo, Yasushi Okada, Yasuhiro Minami, Michiru Nishita.　Commun Biol. 2024 Oct;7(1)1305-1305. DOI: 10.1038/s42003-024-07023-6. PMID: 39394274.
• A highly sensitive reporter system to monitor endogenous YAP1/TAZ activity and its application in various human cells.　Hiroki Hikasa, Kohichi Kawahara, Masako Inui, Yukichika Yasuki, Keita Yamashita, Kohei Otsubo, Shojiro Kitajima, Miki Nishio, Kazunari Arima, Motoyoshi Endo , Masanori Taira, Akira Suzuki.　 Cancer Sci. 2024 Oct;115(10):3370-3383. DOI: 10.1111/cas.16316. PMID: 39155534.
• Ferroptosis induced by plasma-activated RingerFerroptosis induced by plasma-activated Ringer’s lactate solution prevents oral cancer progression’s lactate solution prevents oral cancer progression.　Kotaro Sato, Ming Yang, Kae Nakamura, Hiromasa Tanaka, Masaru Hori, Miki Nishio, Akira Suzuki, Hideharu Hibi, Shinya Toyokuni.　Oral Dis. 2024 :30(3)-.DOI: 10.1111/odi.14827. PMID: 38047766.

代謝　Metabolism

• Differential metabolic secretion between muscular dystrophy mouse-derived spindle cell sarcomas and rhabdomyosarcomas drives tumor type development.　 Emma Tabe Eko Niba, Hiroyuki Awano, Noriyuki Nishimura, Hiroshi Koide, Masafumi Matsuo, Masakazu Shinohara.　Am J Physiol Cell Physiol. 2024 Jul;327(1):C34-C47. DOI: 10.1152/ajpcell.00523.2023. PMID: 38646787.
• ACLY Promotes Cardiac Fibrosis via the Regulation of DNL and Histone Acetylation.　Naoya Kuwahara, Manabu Nagao, Masakazu Shinohara, Kenta Kaneshiro, Takuo Emoto, Takeshi Yoshida, Terunobu Fukuda, Makoto Nishimori, Seimi Satomi-Kobayashi, Hiromasa Otake, Ken-Ichi Hirata, Tatsuro Ishida, Ryuji Toh.　Hypertension. 2025 Mar:82(6).DOI: 10.1161/hypertensionaha.124.24088.
• A Multicenter, Open-Label, Single-Arm Trial of the Efficacy and Safety of Empagliflozin Treatment for Refractory Diabetes Mellitus with Insulin Resistance (EMPIRE-01).　 Yushi Hirota, Yasumasa Kakei, Junta Imai, Hideki Katagiri, Ken Ebihara, Jun Wada, Junichi Suzuki, Tatsuhiko Urakami, Takashi Omori, Wataru Ogawa.　Diabetes Ther. 2024 :15(2)533-545-.DOI: 10.1007/s13300-023-01526-x. PMID: 38216831.
• Adaptive gene expression of alternative splicing variants of PGC-1α regulates whole-body energy metabolism.　 Kazuhiro Nomura, Shinichi Kinoshita, Nao Mizusaki, Yoko Senga, Tsutomu Sasaki, Tadahiro Kitamura, Hiroshi Sakaue, Aki Emi, Tetsuya Hosooka, Masahiro Matsuo, Hitoshi Okamura, Taku Amo, Alexander M Wolf , Naomi Kamimura, Shigeo Ohta, Tomoo Itoh, Yoshitake Hayashi, Hiroshi Kiyonari, Anna Krook, Juleen R Zierath, Masato Kasuga, Wataru Ogawa.　Mol Metab. 2024 Aug;86:101968. DOI: 10.1016/j.molmet.2024.101968. PMID: 38885788.
• A multicenter, open-label, single-arm trial of the long-term safety of empagliflozin treatment for refractory diabetes mellitus with insulin resistance (EMPIRE-02).　Yushi Hirota, Yasumasa Kakei, Junta Imai, Hideki Katagiri, Ken Ebihara, Jun Wada, Junichi Suzuki, Tatsuhiko Urakami, Takashi Omori, Wataru Ogawa.　J Diabetes Investig. 2024 Sept;15(9):1211-1219. DOI: 10.1111/jdi.14226. PMID: 38702973.
• Innervation of the human sternoclavicular joint.　Kenji Emura, Ryo Nitta, Takamitsu Arakawa.　Clin Anat. 2024 Aug. DOI: 10.1002/ ca.24209. PMID:39141520.
• Neuronal Populations Involved in Motor Function Show Prominent Expression of Sbno1 During Postnatal Brain Development.　 Sunjidmaa Zolzaya, Dai Ihara, Munkhsoyol Erkhembaatar, Shinsuke Ochiai, Ayaka Isa, Mariko Nishibe, Jean-Pierre Bellier, Takahiro Shimizu, Satoshi Kikkawa, Ryo Nitta, Yu Katsuyama.　J Dev Biol. 2025 Jan;13(1):3. DOI: 10.3390/jdb13010003. PMID:39982356.
• Degradation of STIM1 through FAM134B-mediated ER-phagy is potentially involved in cell proliferation.　 Hiroaki Kajiho, Toshiaki Sakisaka.　J Biol. Chem. 2024 Sep :300(9):107674. DOI: 10.1016/j.jbc.2024.107674. PMID: 39128711.

脳こころ　Brain and Mind

• C57BL/6J and C57BL/6N mice show distinct aging-associated behavioral alterations.　Rui Yamada, Hirotaka Nagai, Io Horikawa, Wenran Qiu, Yunhui Zhu, Kohei Ota, Tomoyuki Furuyashiki.　J Pharmacol Sci. 2025 Feb; 157(2): 124-129. DOI: 10.1016/j.jphs. 2025.01.002. PMID:39828392.
• The activation of the piriform cortex to lateral septum pathway during chronic social defeat stress is crucial for the induction of behavioral disturbance in mice.　 Yuki Okuda, Dongrui Li, Yuzuki Maruyama, Hirokazu Sonobe, Tomoyuki Mano, Kazuki Tainaka, Ryota Shinohara, Tomoyuki Furuyashiki.　Neuropsychopharmacology. Epub 2024 Dec. DOI: 10.1038/s41386-024-02034-7. PMID: 39638863.
• Potential of GSPT1 as a novel target for glioblastoma therapy.　Takashi Sasayama, Takeshi Hamada, Kazuhiro Tanaka, Hiroaki Nagashima, Shunsuke Yamanishi, Takehiko Ueyama.　Cell Death Dis. 2024 Aug 15(8):572. DOI: 10.1038/s41419-024-06967-1. PMID:39117611.
• A facile assay for zDHHC palmitoyl transferase activation elucidates effects of mutation and modification.　Naoko Adachi, Douglas T Hess, Takehiko Ueyama.　J Lipid Res. 2025 Feb;66(2):100743. DOI: 10.1016/j.jlr.2025.100743. PMID: 39800157.
• Hearing loss occurs prior to thrombocytopenia in both mice and humans with DFNA1.　Shunkou Kurasawa, Akira Ganaha, Shinya Ayabe, Atsushi Yoshiki, Fumiya Kawama, Shota Kitayama, Keiji Tabuchi, Kouhei Yamashita, Takehiko Ueyama.　FASEB J. 2025 Jan39(2):e70309. DOI: 10.1096/fj.202402118R. PMID: 39831886.
• Relationship between residual visual field and full-field stimulus testing in patients with late-stage retinal degenerative diseases.　 Daiki Sakai, Tadao Maeda, Midori Yamamoto, Satoshi Yokota, Akiko Maeda, Yasuhiko Hirami, Makoto Nakamura, Yasuo Kurimoto, Michiko Mandai.　Sci Res. 2024 :14(1)2793. DOI: 10.1038/s41598-024-53474-6. PMID: 38307956.
• High Intraocular Concentration of Fibrinogen Regulates Retinal Function Via the ICAM-1 Pathway.　 Yasuyuki Sotani, Hisanori Imai, Hiroko Yamada, Akiko Miki, Sentaro Kusuhara, Makoto Nakamura.　Invest Ophthalmol Vis Sci. 2024 Nov; 65(13):34. DOI: 10.1167/iovs.65.13.34. PMID: 39546292.
• Remodeling of the postsynaptic proteome in male mice and marmosets during synapse development.　Takeshi Kaizuka, Takehiro Suzuki, Noriyuki Kishi, Kota Tamada, Manfred W Kilimann, Takehiko Ueyama, Masahiko Watanabe, Tomomi Shimogori, Hideyuki Okano, Naoshi Dohmae, Toru Takumi.　Nat Commun. 2024 15(1):2496. DOI: 10.1038/s41467-024-46529-9. PMID: 38548776.
• FAM81A is a postsynaptic protein that regulates the condensation of postsynaptic proteins via liquid-liquid phase separation.　Takeshi Kaizuka, Taisei Hirouchi, Takeo Saneyoshi, Toshihiko Shirafuji, Mark O Collins, Seth G N Grant, Yasunori Hayashi, Toru Takumi.　PLoS Biol. 2024; 22(3)e3002006. DOI: 10.1371/journal.pbio.3002006. PMID: 38452102.
• End-to-end deep learning approach to mouse behavior classification from cortex-wide calcium imaging. Takehiro Ajioka, Nobuhiro Nakai, Okito Yamashita, Toru Takumi.　PLoS Comput Biol. 2024;20(3):e1011074. DOI: 10.1371/journal.pcbi.1011074. PMID: 38478563.
• Accelerated epigenetic aging in alcohol dependence.Toshiyuki Shirai, Satoshi Okazaki, Ikuo Otsuka, Masao Miyachi, Takaki Tanifuji, Ryota Shindo, Shohei Okada, Haruka Minami, Tadasu Horai, Kentaro Mouri, Akitoyo Hishimoto.　J Psychiatr Res. 2024 May:173: 175-182. DOI: 10.1016/j.jpsychires.2024.03.025. PMID: 38547739.
• Increased somatic mosaicism in autosomal and X chromosomes for suicide death.　Ikuo Otsuka, Shunsuke Uchiyama, Toshiyuki Shirai, Xiaoxi Liu, Motonori Takahashi, Yoichiro Kamatani, Chikashi Terao, Akitoyo Hishimoto.　Mol Psychiatry. 2025 Mar; 30(3):881-888. DOI: 10.1038/s41380-024-02718-y. PMID: 39215187.
• Relationship of Major Depressive Disorder and Schizophrenia Polygenic Risk Scores to Suicide: A Comparison Between European and Asian Ancestry Populations.　 Ikuo Otsuka, Hanga Galfalvy, Jia Guo, Masato Akiyama, Satoshi Okazaki, Chikashi Terao, Dan Rujescu, Gustavo Turecki, Akitoyo Hishimoto, J John Mann.　Arch Suicide Res. 2025 Jan-Mar; 29(1):309-316. DOI: 10.1080/13811118.2024.2332258. PMID: 38662626. Epub 2024 Apr 25.

感染症　Infectious Disease

• Spatial-temporal transmission dynamics of HIV-1 CRF01_AE in Indonesia.　Siti Qamariyah Khairunisa, Dwi Wahyu Indriati, Ni Luh Ayu Megasari, Shuhei Ueda, Tomohiro Kotaki, Muhamad Fahmi, Masahiro Ito, Brian Eka Rachman, Afif Nurul Hidayati, Nasronudin, Masanori Kameoka.　Sci Rep. 2024 May; 14(1):9917. DOI: 10.1038/s41598-024-59820-y. PMID: 38730038.
• Low clinical impact of HIV drug resistance mutations in oral pre-exposure prophylaxis: a systematic review and meta-analysis.　Brian Eka Rachman, Siti Qamariyah Khairunisa, Citrawati Dyah Kencono Wungu, Tri Pudy Asmarawati, Musofa Rusli, Bramantono, M Vitanata Arfijanto, Usman Hadi, Masanori Kameoka, Nasronudin.　AIDS Res Ther. 2024 Jun; 21(1):37. DOI: 10.1186/s12981-024-00627-2. PMID: 38844950.
• Further Characterization of the Antiviral Transmembrane Protein MARCH8.　Takuya Tada, Yanzhao Zhang, Dechuan Kong, Michiko Tanaka, Weitong Yao, Masanori Kameoka, Takamasa Ueno, Hideaki Fujita, Kenzo Tokunaga.　Cells. 2024 Apr 13(8):689. DOI: 10.3390/cells13080698. PMID: 38667313.
• Gene-specific somatic epigenetic mosaicism of FDFT1 underlies a non-hereditary localized form of porokeratosis.　 Sonoko Saito, Yuki Saito, Showbu Sato, Satomi Aoki, Harumi Fujita, Yoshihiro Ito, Noriko Ono, Takeru Funakoshi, Tomoko Kawai, Hisato Suzuki, Takashi Sasaki, Tomoyo Tanaka, Masukazu Inoie, Kenichiro Hata, Keisuke Kataoka, Kenjiro Kosaki, Masayuki Amagai, Kazuhiko Nakabayashi, Akiharu Kubo.　Am J Hum Genet. 2024 May ; 111(5):896-912. DOI: 10.1016/j.ajhg.2024.03.017. PMID: 38653249.
• History and prospects of Nagashima‐type palmoplantar keratosis, the most common palmoplantar keratoderma in east Asian populations.　Akiharu Kubo.　J Dermatol. 2025 Mar; 52(3):408-415. DOI: 10.1111/1346-8138.17552. PMID: 39749860.
• Temporal progression of pancreatic cancer computed tomography findings until diagnosis: A large-scale multicenter study.　 Masanori Gonda, Atsuhiro Masuda, Takashi Kobayashi, Takao Iemoto, Saori Kakuyama, Takeshi Ezaki, Takuya Ikegawa, Yuichi Hirata, Hidetaka Tsumura, Kyohei Ogisu, Ryota Nakano, Seiji Fujigaki, Takashi Nakagawa, Megumi Takagi, Kodai Yamanaka, Yu Sato, Koichi Fujita, Keisuke Furumatsu, Takao Kato, Arata Sakai, Hideyuki Shiomi, Tsuyoshi Sanuki, Yoshifumi Arisaka, Yoshihiro Okabe, Hirochika Toyama, Keitaro Sofue, Yuzo Kodama.　United European Gastroenterol J. 2024 Jul;12(6)761-771. DOI: 10.1002/ueg2.12557. PMID: 38451583. Epub 2024 Mar 7.
• Anti-integrin αvβ6 autoantibodies are a potential biomarker for ulcerative colitis-like immune checkpoint inhibitor-induced colitis.　Masataka Yokode, Masahiro Shiokawa, Hisato Kawakami, Takeshi Kuwada, Yoshihiro Nishikawa, Yuya Muramoto, Hiroki Kitamoto, Makoto Okabe, Hajime Yamazaki, Norihiro Okamoto, Toshihiro Morita, Kazuya Ohno, Risa Nakanishi, Ikuhisa Takimoto, Muneji Yasuda, Koki Chikugo, Shimpei Matsumoto, Hiroyuki Yoshida, Sakiko Ota, Takeharu Nakamura, Hirokazu Okada, Tomonori Hirano, Nobuyuki Kakiuchi, Tomoaki Matsumori, Shuji Yamamoto, Norimitsu Uza, Makoto Ooi, Yuzo Kodama, Tsutomu Chiba, Hidetoshi Hayashi, Hiroshi Seno.　Br J Cancer. 2024 May:130(9)1552-1560. DOI: 10.1038/s41416-024-02647-1. PMID: 38461170.
• Wnt-deficient and hypoxic environment orchestrates squamous reprogramming of human pancreatic ductal adenocarcinoma.　Hiroki Tamagawa, Masayuki Fujii, Kazuhiro Togasaki, Takashi Seino, Shintaro Kawasaki, Ai Takano, Kohta Toshimitsu, Sirirat Takahashi, Yuki Ohta, Mami Matano, Kenta Kawasaki, Yujiro Machida, Shigeki Sekine, Akihito Machinaga, Ken Sasai, Yuzo Kodama, Nobuyuki Kakiuchi, Seishi Ogawa, Tomonori Hirano, Hiroshi Seno, Minoru Kitago Yuko Kitagawa, Eisuke Iwasaki, Takanori Kanai, Toshiro Sato.　Nat Cell Biol. 2024 Oct;26(10);1759-1772. DOI: 10.1038/s41556-024-01498-5. PMID: 39232216.
• Unusual G9P[4] Rotavirus Emerged After the Dynamic Changes in Rotavirus Genotypes From Equine-Like G3 to Typical Human G1/G3 in Indonesia.　Zayyin Dinana, Yen Hai Doan, Aussie Tahta Maharani, Anisa Lailatul Fitria, Laura Navika Yamani, Juniastuti, Rury Mega Wahyuni, Soegeng Soegijanto, Soetjipto, Takako Utsumi, Chieko Matsui, Lin Deng, Nobuhiro Takemae, Tsutomu Kageyama, Kazuhiko Katayama, Maria Inge Lusida, Ikuo Shoji.　J Med Virol. 2024 Dec;96(12)e70106. DOI: 10.1002/jmv.70106. PMID: 39670413.
• Identification of glycogen synthase kinase 3alpha/beta as a host factor required for HBV transcription using high-throughput screening.　Hironori Nishitsuji, Yui Naito, Yuuna Murakami, Masaya Sugiyama, Masashi Mizokami, Ikuo Shoji, Takayuki Murata, Kunitada Shimotohno.　Hepatology. 2025 Jan. DOI: 10.1097/HEP.0000000000001239. PMID: 39847392. Online ahead of print.
• Single Amino Acid Substitution Within the Helicase of Varicella Zoster Virus Makes It Resistant to Amenamevir.　Gema Barlian Effendi, Kaito Aoki, Maria Istiqomah Marini, Rei Takamiya, Hanako Ishimaru, Mitsuhiro Nishimura, asuko Mori.　J Med Virol. 2024 Nov;96(11):e70080. DOI: 10.1002/jmv.70080. PMID: 39569446.
• HHV-6B ribonucleotide reductase sequesters NF-κB subunit p65 to inhibit innate immune responses.Mansaku Hirai, Khoir Amaliin, Jing Rin Huang, Salma Aktar, Yasuko Mori, Jun Arii.　iScience. 2024 Dec:28(2). DOI: 10.1016/j.isci.2024.111710. PMID: 39877902. eCollection 2025 Feb 21.
• Epitopes of an antibody that neutralizes a wide range of SARS-CoV-2 variants in a conserved subdomain 1 of the spike protein.　Hanako Ishimaru, Mitsuhiro Nishimura, Hideki Shigematsu, Maria Istiqomah Marini, Natsumi Hasegawa, Rei Takamiya, Sachiyo Iwata, Yasuko Mori.　J Virol. 2024 May:98(5):e0041624. DOI: 10.1128/jvi.00416-24. PMID:38624232. Epub 2024 Apr 16.
• Role of Iron in Children With Immunoglobulin A Nephropathy and Macrohematuria-Induced Acute Kidney Injury.　Shingo Ishimori, Tomoko Horinouchi, Tomohiko Yamamura, Junya Fujimura, Naohiro Kamiyoshi, Hiroshi Kaito, Yuriko Tanaka, Hiroyoshi Matsukura, Wataru Shimabukuro, Yuko Shima, Azusa Kawaguchi, Yoshinori Araki, Koichi Nakanishi, Shigeo Hara, Kandai Nozu　Kidney Int Rep. 2024 Mar; 9(6):1664-1673. DOI: 10.1016/j.ekir.2024.03.003. PMID: 38899207.
• COL4A5 Intronic Variants at Third to Fifth Nucleotides Cause Alport Syndrome.　Hideaki Kitakado, Tomoko Horinouchi, Shuhei Aoyama, Yuka Kimura, Yuta Inoki, Yu Tanaka, Chika Ueda, Yuya Aoto, Nana Sakakibara, China Nagano, Tomohiko Yamamura, Shingo Ishimori, Rini Rossanti, Masafumi Matsuo, Kandai Nozu.　Kidney Int Rep. 2024 Nov 16;10(2):516-521. doi: 10.1016/j.ekir. 2024.11.016. PMID: 39990911. eCollection 2025 Feb.
• Association of perinatal factors with neurodevelopmental referrals in a population-based cohort study in Japan.　Yuki Kyono, Masahiro Nishiyama, Aoi Kawamura, Shizuka Oikawa, Shoichi Tokumoto, Hiroshi Yamaguchi, Kazumi Tomioka, Kandai Nozu, Hiroki Mishina, Hiroaki Nagase.　Sci Rep. 2024:14(1):3492.DOI: 10.1038/s41598-024-54167-w. PMID: 38347064.

再生医学　Regenerative Medicine

• Clinical Characteristics, Surgical Outcomes, and Risk Factors for Emergency Surgery in Patients With Spinal Metastases: A Prospective Cohort Study.　 Yutaro Kanda, Kenichiro Kakutani, Yoshitada Sakai, Takashi Yurube, Yoshiki Takeoka, Kunihiko Miyazaki, Hiroki Ohnishi, Tomoya Matsuo, Masao Ryu, Naotoshi Kumagai, Kohei Kuroshima, Yoshiaki Hiranaka, Ryosuke Kuroda.　Neurospine. 2024 21(1):314-327. DOI: 10.14245/ns.2347012.506. PMID: 38317551.
• Treatment of Osteoporosis in Men on Androgen Deprivation Therapy in Japan.Hanako Nishimoto, Atsuyuki Inui, Yutaka Mifune, Kohei Yamaura, Yukari Bando, Yasuyoshi Okamura, Takuto Hara, Tomoaki Terakawa, Ryosuke Kuroda.　Medicina (Kaunas). 2024 :60(4)551.DOI: 10.3390/medicina60040551. PMID: 38674197.
• SPRR1A is a potential therapeutic target for osteosarcoma: in vitro and in vivo evaluations using generated artificial osteosarcoma cancer stem cell‑like cells.　 Tomohiro Miyamoto, Naomasa Fukase, Teruya Kawamoto, Shuichi Fujiwara, Hitomi Hara, Ryoko Sawada, Yuta Nakamatsu, Yutaka Mifune, Kenichiro Kakutani, Yuichi Hoshino, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Michiyo Koyanagi-Aoi, Takashi Aoi, Toshiyuki Takemori, Shunsuke Yahiro, Ryosuke Kuroda, Toshihiro Akisue.　Oncol Rep. 2025 Feb;53(2):24. DOI: 10.3892/or.2024.8857. PMID: 39704263.
• Effect of a FOXO1 inhibitor on trophoblast differentiation from human pluripotent stem cells and ERV-associated gene expression.　 Erika Tanaka, Michiyo Koyanagi-Aoi, So Nakagawa, Sayumi Shimode, Hideto Yamada, Yoshito Terai, Takashi Aoi.　Regen Ther. 2024 Sep:26:729-740. doi: 10.1016/j.reth.2024.08.020. PMID:39290630. eCollection 2024 Jun.

創薬・医療機器　New Drug & Medical Device Development

• Recent developments in the field of radiotherapy for the management of lung cancer.　 Katsuyuki Shirai, Shuri Aoki, Masashi Endo, Yuta Takahashi, Yukiko Fukuda, Keiko Akahane, Atsushi Musha, Harutoshi Sato, Masaru Wakatsuki, Hitoshi Ishikawa, Ryohei Sasaki.　Jpn J Radiol. 2025 Feb;43(2):186-199. doi: 10.1007/s11604-024-01663-8. PMID: 39316285. Epub 2024 Sep 24.
• A nomogram based on pretreatment radiomics and dosiomics features for predicting overall survival associated with esophageal squamous cell cancer. 　Daisuke Kawahara, Riku Nishioka, Yuji Murakami, Yuki Emoto, Kazuma Iwashita, Ryohei Sasaki.　Eur J Surg Oncol. 2024 Jul;50(7):108450. DOI: 10.1016/j.ejso.2024.108450. PMID: 38843660. Epub 2024 Jun.
• Black Soybean Seed Coat Extract Suppresses Gut Tumorigenesis by Augmenting the Production of Gut Microbiota-Derived Short-Chain Fatty Acids. 　Yasuyuki Shimizu, Shunta Hirano, Mohammed Salah, Namiko Hoshi, Yoko Yamashita, Takeshi Fukumoto, Naritoshi Mukumoto, Ai Nakaoka, Takeaki Ishihara, Daisuke Miyawaki, Hitoshi Ashida, Ryohei Sasaki.　Cancers(Basel). 2024 Nov;16(22):3846. DOI: 10.3390/cancers16223846. PMID:39594801.
• Early experience and future prospects regarding use of newly developed surgical robot system, hinotori, in the field of urologic cancer surgery. 　Hideaki Miyake, Masato Fujisawa.　Int J Clin Oncol. 2024 Jun;29(6):640-646. DOI: 10.1007/s10147-024-02503-5. PMID: 38625439.
• Comparative prognostic value of tumor volume in IOIO and IOTKI treatment for metastatic renal cancer. 　Takuto Hara, Hideto Ueki, Yasuyoshi Okamura, Yukari Bando, Kotaro Suzuki, Tomoaki Terakawa, Koji Chiba, Yoji Hyodo, Jun Teishima, Hideaki Miyake.　Urol Oncol. 2025 Jan;43(1)e19-e27. DOI: 10.1016/j.urolonc.2024.10.015. PMID: 39523170. Epub 2024 Nov 9.
• Utility of Machine Learning Models to Predict Lymph Node Metastasis of Japanese Localized Prostate Cancer. 　Hideto Ueki, Tomoaki Terakawa, Takuto Hara, Munenori Uemura, Yasuyoshi Okamura, Kotaro Suzuki, Yukari Bando, Jun Teishima, Yuzo Nakano, Raizo Yamaguchi, Hideaki Miyake.　Cancers(Basel). 2024 Dec;16(23):4073. DOI: 10.3390/cancers16234073. PMID: 39682259.
• Water-Mediated On-Demand Detachable Solid-State Adhesive of Porous Hydroxyapatite for Internal Organ Retractions. 　Adv Healthc Mater. 2024 Jul;13(19):e2304616. DOI: 10.1002/adhm.202304616. PMID: 38691405. Epub 2024 May.
• Assessment of first-touch skills in robotic surgical training using hi-Sim and the hinotori surgical robot system among surgeons and novices. 　Takeshi Urade, Nobuaki Yamasaki, Munenori Uemura, Junichiro Hirata, Yasuyoshi Okamura, Yuki Mitani, Tatsuya Hattori, Kaito Nanchi, Seiichi Ozawa, Yasuo Chihara, Kiyoyuki Chinzei, Masato Fujisawa, Takumi Fukumoto.　Langenbecks Arch Surg. 2024 Nov;409(1):332. DOI: 10.1007/s00423-024-03514-6. PMID: 39482467.
• Pharmacokinetics of Brexpiprazole, Quetiapine, Risperidone, and Its Active Metabolite Paliperidone in a Postpartum Woman and Her Baby. 　Toru Konishi, Yumi Kitahiro, Naoko Fujiwara, Kazuhiro Yamamoto, Mari Hashimoto, Takahiro Ito, Kotaro Itohara, Kazumichi Fujioka, Hitomi Imafuku, Ikuo Otsuka, Tomohiro Omura, Ikuko Yano.　Ther Drug Monit. 2024 Oct;46(5):687-691. DOI: 10.1097/FTD.0000000000001197. PMID: 38648649 Epub 2024 Apr 4.
• Pharmacokinetic and Pharmacodynamic Assessment of Valganciclovir in Infants With Congenital Cytomegalovirus Infection. 　Kotaro Itohara, Kazuhiro Yamamoto, Shunsuke Fujinaka, Mari Hashimoto, Naoki Tamura, Yumi Kitahiro, Tomohiro Omura, Kazumichi Fujioka, Ikuko Yano.　Ther Drug Monit. 2024 Sep. DOI: 10.1097/FTD.0000000000001257. PMID: 40344019.

AI・デジタルヘルス　プラットフォーム　AI & Degital Health Science

• "Apathetic look" is a valuable indicator of intraoperative supplementary motor area syndrome during awake craniotomy. 　Taiichi Saito, Yoshihiro Muragaki, Bunto Ro, Shunsuke Tsuzuki, Shunichi Koriyama, Ken Masamune, Nobutaka Horie, Takakazu Kawamata.　Neurosurg Rev. 2024 Sep; 47(1):651. DOI: 10.1007/s10143-024-02844-9. PMID: 39304542.
• Classification of speech arrests and speech impairments during awake craniotomy: a multi-databases analysis.　Ilias Maoudj, Atsushi Kuwano, Céline Panheleux, Yuichi Kubota, Takakazu Kawamata, Yoshihiro Muragaki, Ken Masamune, Romuald Seizeur, Guillaume Dardenne, Manabu Tamura. 　Int J Comput Assist Radiol Surg. 2025 Feb;20(2)217-224. DOI: 10.1007/s11548-024-03301-0. PMID: 39652158. Epub 2024 Dec.
• Computerized Classification Method for Molecular Subtypes of Low-Grade Gliomas on Brain MR Images Using Modified ArcFace With Gram-Schmidt Orthogonalization. 　Akiyoshi Hizukuri, Daiki Tanaka, Ryohei Nakayama, Kaori Kusuda, Ken Masamune, Yoshihiro Muragaki.　IEEE ACCESS. 2024;12:194540-194550-.DOI: 10.1109/ACCESS.2024.3520165.

イメージング　プラットフォーム　Imaging

• Periportal macrophages protect against commensal-driven liver inflammation.　Yu Miyamoto, Junichi Kikuta, Takahiro Matsui, Tetsuo Hasegawa, Kentaro Fujii, Daisuke Okuzaki, Yu-chen Liu, Takuya Yoshioka, Shigeto Seno, Daisuke Motooka, Yutaka Uchida, Erika Yamashita, Shogo Kobayashi, Hidetoshi Eguchi, Eiichi Morii, Karl Tryggvason, Takashi Shichita, Hisako Kayama, Koji Atarashi, Jun Kunisawa, Kenya Honda, Kiyoshi Takeda, Masaru Ishii.　Nature. 2024 May;629(8013):901-909. DOI: 10.1038/s41586-024-07372-6. PMID:38658756.
• Sublingual immune cell clusters and dendritic cell distribution in the oral cavity.　 Yutaka Kusumoto, Mizuki Ueda, Mayuko Hashimoto, Haruka Takeuchi, Naoko Okada, Junya Yamamoto, Akiko Nishii, Atsuki Fujino, Akiho Kurahashi, Momoka Satoh, Yuki Iwasa, Koki Okamura, Karin Obazaki, Ryoto Kumagai, Naruya Sakamoto, Yuto Tanaka, Yukika Kamiya, Tetsushi Hoshida, Tsuneyasu Kaisho, Hiroaki Hemmi, Tomoya Katakai, Tetsuya Honda, Junichi Kikuta, Kosuke Kataoka, Ryoyo Ikebuchi, Taiki Moriya, Takahiro Adachi, Takeshi Watanabe, Masaru Ishii, Atsushi Miyawaki, Kenji Kabashima, Tatyana Chtanova, Michio Tomura.　JCI Insight. 2024 Oct;9(21);e167373. DOI: 10.1172/jci.insight.167373. PMID:39352752.
• Transcutaneous carbon dioxide suppresses skeletal muscle atrophy in a mouse model of oral squamous cell carcinoma.　 Aki Sasaki, Daisuke Takeda, Hotaka Kawai, Yoshiaki Tadokoro, Aki Murakami, Nanae Yatagai, Satomi Arimoto, Hitoshi Nagatsuka, Masaya Akashi, Takumi Hasegawa.　PLoS One. 2024 Apr;19(4):e0302194. DOI: 10.1371/journal.pone.0302194. PMID: 38630690.
• Relationship between bone union and degree of bone marrow fibrosis at resection margins of advanced mandibular ORN.　Hiroaki Ohori, Eiji Iwata, Chihiro Ichikawa, Manabu Shigeoka, Yoshiaki Tadokoro,  Daisuke Takeda, Junya Kusumoto, Takumi Hasegawa, Masaya Akashi.　Clin Oral Investig. 2024 Nov:28(11):626. DOI: 10.1007/s00784-024-06008-3. PMID: 39496886.

代謝×脳こころ

• Stress-induced stenotic vascular remodeling via reduction of plasma omega-3 fatty acid metabolite 4-oxoDHA by noradrenaline.　 Makoto Nishimori, Naomi Hayasaka, Kazunori Otsui, Nobutaka Inoue, Junko Asakura, Manabu Nagao, Ryuji Toh, Tatsuro Ishida, Ken-Ichi Hirata, Tomoyuki Furuyashiki, Masakazu Shinohara.　SCIENTIFIC REPORTS. 2024 :14(1):4178. DOI: 10.1038/ s41598-024-54867-3. PMID: 38378892.
• Left atrial single-cell transcriptomics reveals amphiregulin as a surrogate marker for atrial fibrillation. 　Yuya Suzuki, Takuo Emoto, Shunsuke Sato, Takeshi Yoshida, Mitsuhiko Shoda, Hiromi Endoh, Manabu Nagao, Tomoyo Hamana, Taishi Inoue, Tomohiro Hayashi, Eriko Nitta, Hiroki Konishi, Kunihiko Kiuchi, Mitsuru Takami, Kimitake Imamura, Masayuki Taniguchi, Masatoshi Inoue, Toshihiro Nakamura, Yusuke Sonoda, Hiroyuki Takahara, Kazutaka Nakasone, Kyoko Yamamoto, Kenichi Tani, Hidehiro Iwai, Yusuke Nakanishi, Shogo Yonehara, Atsushi Murakami, Ryuji Toh, Takenao Ohkawa, Tomoyuki Furuyashiki, Ryo Nitta, Tomoya Yamashita, Ken-Ichi Hirata, Koji Fukuzawa.　Communications biology. 2024 Dec;7(1):1601. DOI: 10.1038/s42003-024-07308-w. PMID: 39622943.
• Chronic stress alters lipid mediator profiles associated with immune-related gene expressions and cell compositions in mouse bone marrow and spleen. 　Io Horikawa, Hirotaka Nagai, Masayuki Taniguchi, Guowei Chen, Masakazu Shinohara, Tomohide Suzuki, Shinichi Ishii, Yoshio Katayama, Shiho Kitaoka, Tomoyuki Furuyashiki.　J Pharmacol Sci. 2024 Apr;154(4):279-293. DOI: 10.1016/j.jphs.2024.02.010. PMID: 38485346.
• Potentially compromised systemic and local lactate metabolic balance in glaucoma, which could increase retinal glucose and glutamate concentrations.　 Mina Arai-Okuda, Yusuke Murai, Hidetaka Maeda, Akiyasu Kanamori, Takako Miki, Tomoko Naito, Kazunobu Sugihara, Michihiro Kono, Masaki Tanito, Hiromitsu Onoe, Kazuyuki Hirooka, Yoshiaki Kiuchi, Masakazu Shinohara, Sentaro Kusuhara, Sotaro Mori, Kaori Ueda, Mari Sakamoto, Yuko Yamada-Nakanishi, Makoto Nakamura.　Sci Rep. 2024 14(1)3683. DOI: 10.1038/s41598-024-54383-4. PMID: 38355836.

感染症×創薬・医療機器

• SARS-CoV-2 papain-like protease inhibits ISGylation of the viral nucleocapsid protein to evade host anti-viral immunity.　 Aulia Fitri Rhamadianti, Takayuki Abe, Tomohisa Tanaka, Chikako Ono, Hisashi Katayama, Yoshiteru Makino, Lin Deng, Chieko Matsui, Kohji Moriishi, Fumi Shima, Yoshiharu Matsuura, Ikuo Shoji.　J Virol. 2024 Sep;98(9):e0085524. DOI: 10.1128/jvi.00855-24. PMID: 39120134. Epub 2024 Aug.

代謝×再生医学×創薬・医療機器

• Efficient differentiation of human iPSCs into Leydig-like cells capable of long-term stable secretion of testosterone. 　Katsuya Sato, Michiyo Koyanagi-Aoi, Keiichiro Uehara, Yosuke Yamashita, Masakazu Shinohara, Suji Lee, Anika Reinhardt, Knut Woltjen, Koji Chiba, Hideaki Miyake, Masato Fujisawa, Takashi Aoi.　 Stem Cell Reports. 2025 Feb;20(2):102392. DOI: 10.1016/j.stemcr.2024. 102392. PMID: 39824187. Epub 2025 Jan 16.

脳こころ×AI・デジタルヘルス

• Association of preoperative seizures with reduced expression of soluble CD163, an M2 macrophage marker, in the cerebrospinal fluid in isocitrate dehydrogenase wild-type glioblastoma. 　Shunsuke Yamanishi, Hiroaki Nagashima, Kazuhiro Tanaka, Takiko Uno, Yusuke Ikeuchi, Hirofumi Iwahashi, Mitsuru Hashiguchi, Shintaro Horii, Tomoo Itoh, Yoshihiro Muragaki, Takashi Sasayama.　J Neurooncol. 2025 Jan; 171(1):95-103. DOI: 10.1007/s11060-024-04837-6. PMID: 39377994.
• Clinical Benefits of Photodynamic Therapy Using Talaporfin Sodium in Patients With Isocitrate Dehydrogenase-Wildtype Diagnosed Glioblastoma: A Retrospective Study of 100 Cases. 　Yosuke Fujimoto, Yuichi Fujita, Kazuhiro Tanaka, Hiroaki Nagashima, Shunsuke Yamanishi, Yusuke Ikeuchi, Hirofumi Iwahashi, Shoji Sanada, Yoshihiro Muragaki, Takashi Sasayama. 　Neurosurgery. Epub 2024 Nov DOI: 10.1227/neu.0000000000003247. PMID: 39495040.