主要論文一覧(R５度)

センターメンバーにはアンダーライン

難治性がん　Intractable Cancers

• Lysosomal cholesterol overload in macrophages promotes liver fibrosis in a mouse model of NASH.　 Michiko Itoh, Atsushi Tamura, Sayaka Kanai, Miyako Tanaka, Yohei Kanamori, Ibuki Shirakawa, Ayaka Ito, Yasuyoshi Oka, Isao Hidaka, Taro Takami, Yasushi Honda, Mitsuyo Maeda, Yasuyuki Saito, Yoji Murata, Takashi Matozaki, Atsushi Nakajima, Yosky Kataoka, Tomoo Ogi, Yoshihiro Ogawa, Takayoshi Suganami.　J Exp Med. 2023 Nov: 220(11):e20220681. DOI: 10.1084/jem.20220681 PMID: 37725372
• Wnt5a/Ror2 promotes Nrf2‐mediated tissue protective function of astrocytes after brain injury.　 Mitsuharu Endo, Yuki Tanaka, Mayo Fukuoka, Hayata Suzuki, Yasuhiro Minami. Glia. 2023 Oct: 72(2) 411-432 DOI: 10.1002/glia.24483 PMID: 37904612
• Rho family small GTPase Rif regulates Wnt5a-Ror1-Dvl2 signaling and promotes lung adenocarcinoma progression. 　Michiru Nishita, Koki Kamizaki, Kyoka Hoshi, Kana Aruga, Ikumi Nishikaku, Hiroshi Shibuya, Kunio Matsumoto,Yasuhiro Minami.　J Biol Chem. 2023 Oct: 299(10):105248-105248. DOI: 10.1016/j.jbc.2023.105248 PMID: 37703992
• Expression of Ferredoxin1 in cisplatin resistant ovarian cancer cells confers their resistance against ferroptosis induced by cisplatin.　Ryosuke Takahashi, Koki Kamizaki, Keitaro Yamanaka, Yoshito Terai,Yasuhiro Minami.　 Oncol. Rep. 2023 Jun: 49(6):124. DOI: 10.3892/or.2023.8561 PMID: 37144519
• Lethal Phenotype-Based Database Screening Identifies Ceramide as a Negative Regulator of Primitive Streak Formation.　Jing Pu, Satoshi Kofuji, Yoshimi Okamoto-Uchida, Keiko Danzaki, Ruoxing Yu, Akira Suzuki, Satoshi Kitajima, Hiroshi Nishina.　 Stem Cells. 2023 Dec 41(12):1142-1156. DOI:10.1093/stmcls/sxad071. PMID: 37819786
• Ferroptosis induced by plasma-activated Ringer's lactate solution prevents oral cancer progression.　 Kotaro Sato, Ming Yang, Kae Nakamura, Hiromasa Tanaka, Masaru Hori, Miki Nishio, Akira Suzuki, Hideharu Hibi, Shinya Toyokuni.　 Oral Dis. 2023 Dec: DOI: 10.1111/odi.14827 PMID: 38047766
• Oral Microbial Profile Analysis in Patients with Oral and Pharyngeal Cancer Reveals That Tumoral Fusobacterium nucleatum Promotes Oral Cancer Progression by Activating YAP. Yuki Yamamoto, Tomonori Kamiya, Megumu Yano, Vu Thuong Huyen, Masahiro Oishi, Miki Nishio, Akira Suzuki, Kishiko Sunami, Naoko Ohtani.　 Microorganisms. 2023 Dec: 11(12):2957. DOI: 10.3390/microorganisms11122957 PMID: 38138101
• IFI16 Induced by Direct Interaction between Esophageal Squamous Cell Carcinomas and Macrophages Promotes Tumor Progression via Secretion of IL-1α.　Yuki Azumi, Yu-ichiro Koma, Shuichi Tsukamoto, Yu Kitamura, Nobuaki Ishihara, Keitaro Yamanaka, Takashi Nakanishi, Shoji Miyako, Satoshi Urakami, Kohei Tanigawa, Takayuki Kodama, Mari Nishio, Manabu Shigeoka, Yoshihiro Kakeji, Hiroshi Yokozaki.　Cells 2023 Nov: 12(22):2603-2603. DOI: 10.3390/cells12222603 PMID: 37998338
• Addition of docetaxel to S－1 results in significantly superior 5-year survival outcomes in Stage III gastric cancer: a final report of the JACCRO GC-07 study. Yasuhiro Kodera, Kazuhiro Yoshida, Mitsugu Kochi, Takeshi Sano, Wataru Ichikawa, Yoshihiro Kakeji, Yu Sunakawa, Masahiro Takeuchi, Masashi Fujii.　 Gastric cancer. 2023 Nov: 26(6):1063-1068. DOI:10.1007/s10120-023-01419-9 PMID: 37548812
• Real-world Evaluation of the Efficacy of Neoadjuvant DCF Over CF in Esophageal Squamous Cell Carcinoma: Propensity Score-matched Analysis From 85 Authorized Institutes for Esophageal Cancer in Japan. 　 Satoru Matsuda, Yuko Kitagawa, Ryo Takemura, Jun Okui, Akihiko Okamura, Hirofumi Kawakubo, Manabu Muto, Yoshihiro Kakeji, Hiroya Takeuchi, Masayuki Watanabe, Yuichiro Doki.　 Ann Surg. 2023 Jul: 278(1):e35-e42. DOI: 10.1097/SLA.0000000000005533 PMID: 35837977

代謝　Metabolism

• Structural basis of Irgb6 inactivation by Toxoplasma gondii through the phosphorylation of switch I.　Hiromichi Okuma, Yumiko Saijo‐Hamano, Hiroshi Yamada, Aalaa Alrahman Sherif, Emi Hashizaki, Naoki Sakai, Takaaki Kato, Tsuyoshi Imasaki, Satoshi Kikkawa, Eriko Nitta, Miwa Sasai, Tadashi Abe, Fuminori Sugihara, Yoshimasa Maniwa, Hidetaka Kosako, Kohji Takei, Daron M. Standley, Masahiro Yamamoto, Ryo Nitta.　Genes Cells 2023 Nov :29(1): 17-38 .DOI: 10.1111/gtc.13080 PMID:37984375
• TEAD1 trapping by the Q353R–Lamin A/C causes dilated cardiomyopathy.　 Shintaro Yamada, Toshiyuki Ko, Masamichi Ito, Tatsuro Sassa, Seitaro Nomura, Hiromichi Okuma, Mayuko Sato, Tsuyoshi Imasaki, Satoshi Kikkawa, Bo Zhang, Takanobu Yamada, Yuka Seki, Kanna Fujita, Manami Katoh, Masayuki Kubota, Satoshi Hatsuse, Mikako Katagiri, Hiromu Hayashi, Momoko Hamano, Norifumi Takeda, Hiroyuki Morita, Shuji Takada, Masashi Toyoda, Masanobu Uchiyama, Masashi Ikeuchi, Kiminori Toyooka, Akihiro Umezawa, Yoshihiro Yamanishi, Ryo Nitta, Hiroyuki Aburatani, Issei Komuro.　Sci. Adv. 2023 Apr: 9(15):eade7047. DOI: 10.1126/sciadv.ade7047 PMID: 37058558
• Novel UV-B Phototherapy With a Light-Emitting Diode Device Prevents Atherosclerosis by Augmenting Regulatory T-Cell Responses in Mice.　 Toru Tanaka, Naoto Sasaki, Aga Krisnanda, Masakazu Shinohara, Hilman Zulkifli Amin, Sayo Horibe, Ken Ito, Motoaki Iwaya, Atsushi Fukunaga, Ken-Ichi Hirata , Yoshiyuki Rikitake.　J of Am Heart Assoc. 2024 Jan; 13(2):e031639.DOI: 10.1161/JAHA.123.031639 PMID: 38214259
• Endothelial senescence alleviates cognitive impairment in a mouse model of Alzheimer's disease.　Sayo Horibe, Takuo Emoto, Taiji Mizoguchi, Toru Tanaka, Shoji Kawauchi, Naoto Sasaki, Tomoya Yamashita, Koji Ikeda, Noriaki Emoto, Ken-Ichi Hirata, Yoshiyuki Rikitake.　Glia. 2024 Jan; 72(1) :51-68. DOI: 10.1002/glia.24461 PMID: 37610154
• The relationship between unique gut microbiome-derived lipid metabolites and subsequent revascularization in patients who underwent percutaneous coronary intervention.　 Daichi Fujimoto, Masakazu Shinohara, Hiroyuki Kawamori, Takayoshi Toba, Shunsuke Kakizaki, Koichi Nakamura, Satoru Sasaki, Tomoyo Hamana, Hiroyuki Fujii, Yuto Osumi, Naomi Hayasaka, Shigenobu Kishino, Jun Ogawa, Ken-ichi Hirata, Hiromasa Otake.　Atherosclerosis. 2023 Jun: 375:1-8. DOI: 10.1016/j.atherosclerosis.2023.05.001 PMID : 37216727

脳こころ　Brain and Mind

• The dynamics of cortical interactions in visual recognition of object category: living vs non-living. 　Kiyohide Usami, Riki Matsumoto, Anna Korzeniewska, Akihiro Shimotake, Masao Matsuhashi, Takuro Nakae, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Ryosuke Takahashi, Nathan E Crone, Akiko Ikeda.　 Cereb Cortex. 2023 Apr: 33(9):5740-5750. DOI: 10.1093/cercor/bhac456 PMID: 36408645
• Representational similarity learning reveals a graded multidimensional semantic space in the human anterior temporal cortex. 　Christopher R.Cox, Timothy Rogers, Akihiro Shimotake, Takayuki Kikuchi, Takeharu Kunieda, Susumu Miyamoto, Tyosuke Takahashi, Riki Matsumoto, Akiko Ikeda Matthew A. Lambon Ralph.　Imaging Neuroscience. 2024 Feb: 2 DOI:10.1162/imag_a_00093
• Mesial temporal lobe epilepsy with amygdalar hamartoma-like lesion: Is it a distinct syndrome? 　Kiminobu Okayama, Naotaka Usui, Takashi Matsudaira, Akihiko Kondo, Yasukiyo Araki, Norihiko Kawaguchi, Kazumi Matsuda, Takayasu Tottori, Kiyohito Terada, Riki Matsumoto, Yukitoshi Takahashi.　Epilepsy Res. 2023 May: 192:107140. DOI:10.1016/j.eplepsyres.2023.107140 PMID : 37037096
• High salt induces cognitive impairment via the interaction of angiotensin II-AT₁ and prostaglandin E2-EP₁ systems.　 Hisayoshi Kubota, Kazuo Kunisawa, Bolati Wulaer, Masaya Hasegawa, Hitomi Kurahashi, Takatoshi Sakata, Hiroyuki Tezuka, Masanori Kugita, Shizuko Nagao, Taku Nagai, Tomoyuki Furuyashiki, Shuh Narumiya, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri.　Br J Pharmacol. 2023 Sep: 180(18):2393-2411.DOI: 10.1111/bph.16093 PMID: 37076133
• Repeated Social Defeat Stress Induces HMGB1 Nuclear Export in Prefrontal Neurons, Leading to Social Avoidance in Mice. 　Shiho Kitaoka, Ayaka Tomohiro, Shinya Ukeshima, Keyue Liu, Hidenori Wake, Shinya H Kimura, Yasuhiko Yamamoto, Masahiro Nishibori, Tomoyuki Furuyashiki.　 Cells. 2023 Jul: 12(13):1789. DOI: 10.3390/cells12131789 PMID: 37443823
• Remodeling of the postsynaptic proteome in male mice and marmosets during synapse development.　 Takeshi Kaizuka, Takehiro Suzuki, Noriyuki Kishi, Kota Tamada, Manfred W Kilimann, Takehiko Ueyama, Masahiko Watanabe, Hideyuki Okano, Naoshi Dohmae, Tomomi Shimogori, Toru Takumi.　 Nat. Commun. 2024 Mar: 15(1):2496. DOI: 10.1038/s41467-024-46529-9 PMID: 38548776
• FAM81A is a postsynaptic protein that regulates the condensation of postsynaptic proteins via liquid-liquid phase separation.　 Takeshi Kaizuka, Taisei Hirouchi, Takeo Saneyoshi, Toshihiko Shirafuji, Mark O Collins, Seth G N Grant, Yasunori Hayashi, Toru Takumi.　PLoS Biol. 2024 Mar: 22(3):e3002006-. DOI:10.1371/journal.pbio.3002006 PMID: 38452102
• Social circuits and their dysfunction in autism spectrum disorder.　Masaaki Sato, Nobuhiro Nakai, Shuhei Fujima, Katrina Y Choe, Toru Takumi.　 Mol Psychiatry. 2023 Aug: 28(8):3194-3206. DOI: 10.1038/s41380-023-02201-0 PMID: 37612363
• Mapping the genetic architecture of suicide attempt and suicide death using polygenic risk scores for clinically-related psychiatric disorders and traits.　 Ikuo Otsuka, Hanga Galfalvy, Jia Guo, Masato Akiyama, Dan Rujescu, Gustavo Turecki, Akitoyo Hishimoto , J John Mann.　Psychol Med. 2023 Apr: 53(6):2689-2697.DOI: 10.1017/S0033291721004700 PMID: 37310312
• Epigenetic clock analysis reveals increased plasma cystatin C levels based on DNA methylation in major depressive disorder. 　Takaki Tanifuji, Satoshi Okazaki, Ikuo Otsuka, Kentaro Mouri, Tadasu Horai, Ryota Shindo, Toshiyuki Shirai, Akitoyo Hishimoto.　Psychiatry Res. 2023 Apr: 322:115103-115103. DOI: 10.1016/j.psychres.2023.115103 PMID: 36803907
• Delayed facial palsy after resection of vestibular schwannoma: does it influence long-term facial nerve functional outcomes? 　Yuichi Fujita, Yoichi Uozumi, Nobuyuki Akutsu, Takashi Sasayama, Eiji Kohmura.　J Neurosurg. 2023 Dec: 140(6):1605-1613. DOI: 10.3171/2023.10.JNS231581 PMID: 38100764
• Subclassification of Koos grade 4 vestibular schwannoma: insights into tumor morphology for predicting postoperative facial nerve function. 　Yuichi Fujita, Yoichi Uozumi, Takashi Sasayama, Eiji Kohmura.　J Neurosurg. 2023 Jul :1-11.DOI: 10.3171/2023.5.JNS23715 PMID: 37503933
• Dispensable role of Rac1 and Rac3 after cochlear hair cell specification.　 Takashi Nakamura, Hirofumi Sakaguchi, Hiroaki Mohri, Yuzuru Ninoyu, Akihiro Goto, Taro Yamaguchi, Yoshitaka Hishikawa, Michiyuki Matsuda, Naoki Saito, Takehiko Ueyama.　J. Mol. Med. 2023 Jul 101(7):843-854. DOI:10.1007/s00109-023-02317-4 PMID: 37204479
• Loss of synaptic ribbons is an early cause in ROS-induced acquired sensorineural hearing loss.　Shunkou Kurasawa, Hiroaki Mohri, Keiji Tabuchi,Takehiko Ueyama.　 Neurobiol. Dis. 2023 Oct: 186:106280. DOI:10.1016/j.nbd.2023.106280 PMID: 37666363
• GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors.　 Anna R Docherty, Niamh Mullins, Allison E Ashley-Koch, Xuejun Qin, Jonathan R I Coleman, Andrey Shabalin, JooEun Kang, Balasz Murnyak, Frank Wendt, Mark Adams, Adrian I Campos, Emily DiBlasi, Janice M Fullerton, Henry R Kranzler, Amanda V Bakian, Eric T Monson, Miguel E Rentería, Consuelo Walss-Bass, Ole A Andreassen, Chittaranjan Behera, Cynthia M Bulik, Howard J Edenberg, Ronald C Kessler, J John Mann, John I Nurnberger Jr, Giorgio Pistis, Fabian Streit, Robert J Ursano, Renato Polimanti, Michelle Dennis, Melanie Garrett, Lauren Hair, Philip Harvey, Elizabeth R Hauser, Michael A Hauser, Jennifer Huffman, Daniel Jacobson, Ravi Madduri, Benjamin McMahon, David W Oslin, Jodie Trafton, Swapnil Awasthi, Wade H Berrettini, Martin Bohus, Xiao Chang, Hsi-Chung Chen, Wei J Chen, Erik D Christensen, Scott Crow, Philibert Duriez, Alexis C Edwards, Fernando Fernández-Aranda, Hanga Galfalvy, Michael Gandal, Philip Gorwood, Yiran Guo, Jonathan D Hafferty, Hakon Hakonarson, Katherine A Halmi, Akitoyo Hishimoto, Sonia Jain, Stéphane Jamain, Susana Jiménez-Murcia, Craig Johnson, Allan S Kaplan, Walter H Kaye, Pamela K Keel, James L Kennedy, Minsoo Kim, Kelly L Klump, Daniel F Levey, Dong Li, Shih-Cheng Liao, Klaus Lieb, Lisa Lilenfeld, Christian R Marshall, James E Mitchell, Satoshi Okazaki, Ikuo Otsuka, Dalila Pinto, Abigail Powers, Nicolas Ramoz, Stephan Ripke, Stefan Roepke, Vsevolod Rozanov, Stephen W Scherer, Christian Schmahl, Marcus Sokolowski, Anna Starnawska, Michael Strober, Mei-Hsin Su, Laura M Thornton, Janet Treasure, Erin B Ware, Hunna J Watson, Stephanie H Witt, D Blake Woodside, Zeynep Yilmaz, Lea Zillich, Rolf Adolfsson, Ingrid Agartz, Martin Alda, Lars Alfredsson, Vivek Appadurai, María Soler Artigas, Sandra Van der Auwera, M Helena Azevedo, Nicholas Bass, Claiton H D Bau, Bernhard T Baune, Frank Bellivier, Klaus Berger, Joanna M Biernacka, Tim B Bigdeli, Elisabeth B Binder, Michael Boehnke, Marco P Boks, David L Braff, Richard Bryant, Monika Budde, Enda M Byrne, Wiepke Cahn, Enrique Castelao, Jorge A Cervilla, Boris Chaumette, Aiden Corvin, Nicholas Craddock, Srdjan Djurovic, Jerome C Foo, Andreas J Forstner, Mark Frye, Justine M Gatt, Ina Giegling, Hans J Grabe, Melissa J Green, Eugenio H Grevet, Maria Grigoroiu-Serbanescu, Blanca Gutierrez, Jose Guzman-Parra, Marian L Hamshere, Annette M Hartmann, Joanna Hauser, Stefanie Heilmann-Heimbach, Per Hoffmann, Marcus Ising, Ian Jones, Lisa A Jones, Lina Jonsson, René S Kahn, John R Kelsoe, Kenneth S Kendler, Stefan Kloiber, Karestan C Koenen, Manolis Kogevinas, Marie-Odile Krebs, Mikael Landén, Marion Leboyer, Phil H Lee, Douglas F Levinson, Calwing Liao, Jolanta Lissowska, Fermin Mayoral, Susan L McElroy, Patrick McGrath, Peter McGuffin, Andrew McQuillin, Divya Mehta, Ingrid Melle, Philip B Mitchell, Esther Molina, Gunnar Morken, Caroline Nievergelt, Markus M Nöthen, Michael C O'Donovan, Roel A Ophoff, Michael J Owen, Carlos Pato, Michele T Pato, Brenda W J H Penninx, James B Potash, Robert A Power, Martin Preisig, Digby Quested, Josep Antoni Ramos-Quiroga, Andreas Reif, Marta Ribasés, Vanesa Richarte, Marcella Rietschel, Margarita Rivera, Andrea Roberts, Gloria Roberts, Guy A Rouleau, Diego L Rovaris, Alan R Sanders, Peter R Schofield, Thomas G Schulze, Laura J Scott, Alessandro Serretti, Jianxin Shi, Lea Sirignano, Pamela Sklar, Olav B Smeland, Jordan W Smoller, Edmund J S Sonuga-Barke, Maciej Trzaskowski, Ming T Tsuang, Gustavo Turecki, Laura Vilar-Ribó, John B Vincent, Henry Völzke, James T R Walters, Cynthia Shannon Weickert, Thomas W Weickert, Myrna M Weissman, Leanne M Williams, Naomi R Wray, Clement C Zai, Esben Agerbo, Anders D Børglum, Gerome Breen, Ditte Demontis, Annette Erlangsen, Joel Gelernter, Stephen J Glatt, David M Hougaard, Hai-Gwo Hwu, Po-Hsiu Kuo, Cathryn M Lewis, Qingqin S Li, Chih-Min Liu, Nicholas G Martin, Andrew M McIntosh, Sarah E Medland, Ole Mors, Merete Nordentoft, Catherine M Olsen, David Porteous, Daniel J Smith, Eli A Stahl, Murray B Stein, Danuta Wasserman, Thomas Werge, David C Whiteman, Virginia Willour, Hilary Coon, Jean C Beckham, Nathan A Kimbrel, Douglas M Ruderfer.　The Am J Psychiatry. 2023 Oct: 180(10):723-738. DOI:10.1176/appi.ajp.21121266 PMID :37777856

感染症　Infectious Disease

• Keratinocytes of the Upper Epidermis and Isthmus of Hair Follicles Express Hemoglobin mRNA and Protein.　Umi Tahara, Takeshi Matsui, Toru Atsugi, Keitaro Fukuda, Tommy W Terooatea, Aki Minoda, Akiharu Kubo, Masayuki Amagai.　 J Invest Dermatol. 2023 Dec: 143(12):2346-2355. DOI: 10.1016/j.jid.2023.08.008 PMID: 37981423
• Two sporadic cases of childhood-onset Hailey-Hailey disease with superimposed mosaicism. 　 Yasuhiko Asahina, Umi Tahara, Satomi Aoki, Kazuhiko Nakabayashi, Chiharu Tateishi, Daisuke Hayashi, Masayuki Amagai, Daisuke Tsuruta, Akiharu Kubo.　 Eur J Hum Genet. 2023 Jan: 31(6):716-720. DOI: 10.1038/s41431-023-01316-w PMID: 36922631
• Outcomes of endoscopic submucosal dissection for esophageal cancer with segmental absence of intestinal musculature. 　 Tetsuya Yoshizaki, Yoshinobu Yamamoto, Tomoya Sako, Yasuaki Kitamura, Takayuki Ose, Tsukasa Ishida, Atsushi Ikeda, Ryusuke Ariyoshi, Mineo Iwatate, Fumiaki Kawara, Shinwa Tanaka, Toshitatsu Takao, Yoshinori Morita, Takashi Toyonaga, Yuzo Kodama.　 Gastrointest Endosc. 2023 Nov: DOI: 10.1016/j.gie.2023.11.007 PMID: 37952682
• Human herpesvirus 6A nuclear matrix protein U37 interacts with heat shock transcription factor 1 and activates the heat shock response. 　Jing Rin Huang, Jun Arii, Mansaku Hirai, Mitsuhiro Nishimura, Yasuko Mori.　J Virology 2023 Sep: 97(9):e0071823-.DOI: 10.1128/jvi.00718-23 PMID: 37671864
• Fourth mRNA vaccination increases cross-neutralizing antibody titers against SARS-CoV-2 variants, including BQ.1.1 and XBB, in a very elderly population. 　Silvia Sutandhio, Koichi Furukawa, Yukiya Kurahashi, Maria Istiqomah Marini, Gema Barlian Effendi, Natsumi Hasegawa, Hanako Ishimaru, Mitsuhiro Nishimura, Jun Arii, Yasuko Mori.　 J Infect Public Health. 2023 Jul: 16(7):1064-1072. DOI:10.1016/j.jiph.2023.05.004 PMID: 37196370

再生医学　Regenerative Medicine

• Re-generation of cytotoxic γδT cells with distinctive signatures from human γδT-derived iPSCs. 　Nobuyuki Murai, Michiyo Koyanagi-Aoi, Hiroto Terashi, Takashi Aoi.　Stem Cell Reports 2023 Apr :18(4):853-868. DOI:10.1016/j.stemcr.2023.02.010 PMID: 36963392
• Clinical Characteristics and Surgical Outcomes of Metastatic Spine Tumors in the Very Elderly: A Prospective Cohort Study in a Super-Aged Society. 　Yutaro Kanda, Kenichiro Kakutani, Yoshitada Sakai, Kunihiko Miyazaki, Tomoya Matsuo, Takashi Yurube, Yoshiki Takeoka, Hiroki Ohnishi, Masao Ryu, Naotoshi Kumagai, Kohei Kuroshima, Yoshiaki Hiranaka, Teruya Kawamoto, Hitomi Hara, Yuichi Hoshino, Shinya Hayashi, Toshihiro Akisue, Ryosuke Kuroda.　J Clin Med. 2023 Jul: 12(14):4747. DOI: 10.3390/jcm12144747 PMID: 37510862
• Clinical Characteristics, Surgical Outcomes, and Risk Factors for Emergency Surgery in Patients With Spinal Metastases: A Prospective Cohort Study. 　 Yutaro Kanda, Kenichiro Kakutani, Yoshitada Sakai, Takashi Yurube, Yoshiki Takeoka, Kunihiko Miyazaki, Hiroki Ohnishi, Tomoya Matsuo, Masao Ryu, Naotoshi Kumagai, Kohei Kuroshima, Yoshiaki Hiranaka, Ryosuke Kuroda.　Neurospine. 2024 Mar: 21(1): 314-327. DOI: 10.14245/ns.2347012.506 PMID: 38317551
• Pcgf1 gene disruption reveals primary involvement of epigenetic mechanism in neuronal subtype specification in the enteric nervous system. 　Bayu Pratama Putra, Keisuke Ito, Carla Cirillo, Mukhamad Sunardi, Haruhiko Koseki, Toshihiro Uesaka, Hideki Enomoto.　Dev Growth Differ. 2023 Oct: 65(8): 461-469. DOI: 10.1111/dgd.12880 PMID: 37452641

創薬・医療機器　New Drug & Medical Device Development

• Population pharmacokinetics of everolimus in renal transplant recipients receiving long-term multiple immunosuppressive therapy.　 Tomoyuki Sakaue, Kazuhiro Yamamoto, Kotaro Itohara, Yumi Kitahiro, Takahito Endo, Naoki Yokoyama, Takeshi Ishimura, Tomohiro Omura, Ikuko Yano.　Drug Metab Pharmacokinet. 2024 Epub 2024 Mar 12. DOI: 10.1016/j.dmpk.2024.101009 PMID: 38547661
• A model-based pharmacokinetic assessment of drug–drug interaction between tacrolimus and nirmatrelvir/ritonavir in a kidney transplant patient with COVID-19.　 Takeshi Tomida, Kotaro Itohara, Kazuhiro Yamamoto, Takeshi Kimura, Kohei Fujita, Atsushi Uda, Yumi Kitahiro, Naoki Yokoyama, Yoji Hyodo, Tomohiro Omura, Ikuko Yano.　 Drug Metab Pharmacokinet 2023 Sep: DOI: 10.1016/j.dmpk.2023.100529 PMID: 37924724
• Luteolin Protects Against 6-Hydoroxydopamine-Induced Cell Death via an Upregulation of HRD1 and SEL1L.　 Hiroki Nishiguchi, Tomohiro Omura, Ayaka Sato, Yumi Kitahiro, Kazuhiro Yamamoto, Junichi Kunimasa, Ikuko Yano.　 Neurochem Research 2024 Jan;49(1):117-128. DOI: 10.1007/s11064-023-04019-2 PMID: 37632637 Epub 2023 Aug
• Clinical impact of spacer placement surgery with expanded polytetrafluoroethylene sheet for particle therapy.　 Ryosuke Fujinaka, Shohei Komatsu, Kazuki Terashima, Yusuke Demizu, Satoshi Omiya, Masahiro Kido, Hirochika Toyama, Sunao Tokumaru, Tomoaki Okimoto, Takumi Fukumoto. Radiat Oncol. 2023 Oct: 18(1):173. DOI: 10.1186/s13014-023-02359-5 PMID: 37875956
• Comparative study of sub-second temporal resolution 4D-MRI and 4D-CT for target motion assessment in a phantom model. 　Tianyuan Wang, Keitaro Sofue, Ryuji Shimada, Takeaki Ishihara, Ryuichi Yada, Masanori Miyamoto, Ryohei Sasaki, Takamichi Murakami.　Sci Rep. 2023 Sep: 13(1):15685-. DOI: 10.1038/s41598-023-42773-z PMID: 37735180
• Asciminib monotherapy in patients with CML-CP without BCR::ABL1 T315I mutations treated with at least two prior TKIs: 4-year phase 1 safety and efficacy results　 Michael J Mauro, Timothy P Hughes, Dong-Wood Kim, Delpjome Réa, Jorge E Cortes, Andreas Hochhaus, Koji Sasaki, Massimo Breccia, Moshe Talpaz, Oliver Ottmann, Hironobu Minami, Yeow Tee Goh, Daniel J DeAngelo, Michael C Heinrich, Valle Gómez-García de Soria,　 Philipp Le Coutre, Francois-Xavier Mahon, Jeroen J W M Janssen, Michael Deininger, Naranie Shanmuganathan, Mark B Geyer, Silvia Cacciatore, Fotis Polydoros, Nithya Agrawal, Matthias Hoch, Fabian Lang.　Leukemia. 2023 May: 37(5):1048-1059. DOI: 10.1038/s41375-023-01860-w PMID: 36949155
• Safety and antitumor activity of copanlisib in Japanese patients with relapsed/refractory indolent non-Hodgkin lymphoma: a phase Ib/II study.　Noriko Fukuhara, Dai Maruyama, Kiyohito Hatake, Hirokazu Nagai, Shinichi Makita, Kenjiro Kamezaki, Toshiki Uchida, Shigeru Kusumoto, Junya Kuroda, Chisako Iriyama, Masamitsu Yanada, Norifumi Tsukamoto, Youko Suehiro, Hironobu Minami, Jose Garcia-Vargas, Barrett H Childs, Masanobu Yasuda, Shigeo Masuda, Toshiaki Tsujino, Yui Terao, Kensei Tobinai.　Int J Hematol. 2023 Jan: 117(1):110-109. DOI:10.1007/s12185-022-03455-0 PMID: 36175779
• Stepwise prolongation of overall survival from first to third generation EGFR-TKIs for EGFR mutation-positive non-small-cell lung cancer: the Tokushukai REAl-world Data project (TREAD 01) 　 Kiyoaki Uryu, Yoshinori Imamura, Rai Shimoyama, Takahiro Mase, Yoshiaki Fujimura, Maki Hayashi, Megu Ohtaki, Keiko Otani, Makoto Hibino, Shigeto Horiuchi, Tomoya Fukui, Ryuta Fukai, Yusuke Chihara, Akihiko Iwase, Noriko Yamada, Yukihiro Tamura, Hiromasa Harada, Nobuaki Shinozaki, Asuka Tsuya, Masahiro Fukuoka, Hironobu Minami.　Jpn J Clin Oncol. 2024 Mar: 54(3):319-328. DOI: 10.1093/jjco/hyad162 PMID: 37997468
• Innovative Combination Treatment to Expand the Indications of Particle Therapy: Spacer Placement Surgery Using Bio-Absorbable Polyglycolic Acid Spacer.　 Shohei Komatsu, Tianyuan Wang, Kazuki Terashima, Yusuke Demizu, Makoto Anzai, Masaki Suga, Tomohiro Yamashita, Osamu Suzuki, Tomoaki Okimoto, Ryohei Sasaki, Takumi Fukumoto.　J Am Coll Surg. 2024 Jan: 238(1):119-128. DOI:10.1097/XCS.0000000000000873 PMID: 37737669

感覚器プラットフォーム　Sensory Systems

• Potentially compromised systemic and local lactate metabolic balance in glaucoma, which could increase retinal glucose and glutamate concentrations. 　Mina Arai-Okuda, Yusuke Murai, Hidetaka Maeda, Akiyasu Kanamori, Takako Miki, Tomoko Naito, Kazunobu Sugihara, Michihiro Kono, Masaki Tanito, Hiromitsu Onoe, Kazuyuki Hirooka, Yoshiaki Kiuchi, Masakazu Shinohara, Sentaro Kusuhara, Sotaro Mori, Kaori Ueda, Mari Sakamoto, Yuko Yamada-Nakanishi, Makoto Nakamura.　Sci Rep. 2024 Feb: 14(1):3683-3683. DOI: 10.1038/s41598-024-54383-4 PMID: 38355836
• Favorable effect of ripasudil use on surgical outcomes of microhook ab interno trabeculotomy.　 Mina Okuda, Sotaro Mori, Kaori Ueda, Mari Sakamoto, Sentaro Kusuhara, Yuko Yamada-Nakanishi, Makoto Nakamura.　 Graefes Arc Clin Exp Ophthalmol. 2023 Sep : 261(9):2603-2610. DOI: 10.1007/s00417-023-06040-1 PMID: 37000272
• Detection of Relative Afferent Pupillary Defect and Its Correlation with Structural and Functional Asymmetry in Patients with Glaucoma Using Hitomiru, a Novel Hand-Held Pupillometer. 　Makoto Nakamura, Mari Sakamoto, Kaori Ueda, Mina Okuda, Fumio Takano, Yuko Yamada-Nakanishi.　J Clin Med. 2023 Jun: 12(12):3936. DOI: 10.3390/jcm12123936 PMID: 37373631

難治性がん×創薬・医療機器

• Preclinical evaluation of the efficacy of an antibody to human SIRPα for cancer immunotherapy in humanized mouse models.　Yasuyuki Saito, Rie Iida-Norita, Tania Afroj, Alaa Refaat, Daisuke Hazama, Satomi Komori, Shinya Ohata, Tomoko Takai, Okechi S. Oduori, Takenori Kotani, Yohei Funakoshi, Yu-Ichiro Koma, Yoji Murata, Kimikazu Yakushijin, Hiroshi Matsuoka, Hironobu Minami, Hiroshi Yokozaki, Markus G. Manz, Takashi Matozaki.　Front Immunol. 2023 Dec: 14:1294814. DOI: 10.3389/fimmu.2023.1294814 PMID: 38162643

難治性がん×代謝

• CD47 promotes peripheral T cell survival by preventing dendritic cell–mediated T cell necroptosis.　 Satomi Komori, Yasuyuki Saito, Taichi Nishimura, Datu Respatika, Hiromi Endoh, Hiroki Yoshida, Risa Sugihara, Rie Iida-Norita, Tania Afroj, Tomoko Takai, Okechi S. Oduori, Eriko Nitta, Takenori Kotani, Yoji Murata, Yoriaki Kaneko, Ryo Nitta, Hiroshi Ohnishi, Takashi Matozaki.　Proc Natl Acad Sci U S A. 2023 Aug: 120(33):e2304943120. DOI: 10.1073/pnas.2304943120 PMID: 37549290

代謝×脳こころ

• Stress-induced stenotic vascular remodeling via reduction of plasma omega-3 fatty acid metabolite 4-oxoDHA by noradrenaline. 　Makoto Nishimori, Naomi Hayasaka, Kazunori Otsui, Nobutaka Inoue, Manabu Nagao, Ryuji Toh, Tatsuro Ishida, Ken-ichi Hirata, Tomoyuki Furuyashiki, Masakazu Shinohara.　Sci Rep. 2024 Feb: 14(1):4178. DOI: 10.1038/s41598-024-54867-3 PMID: 38378892

感染症×創薬・医療機器

• Oncological outcomes of concurrent chemoradiotherapy with docetaxel, cisplatin, and 5-fluorouracil for locally advanced squamous cell carcinoma of the external auditory canal: A single-center study.　 Akihiro Yamada, Hirotaka Shinomiya, Natsumi Uehara, Keisuke Iritani, Shun Tatehara, Tatsuya Furukawa, Masanori Teshima, Daisuke Miyawaki, Takeshi Fujita, Akinobu Kakigi, Naomi Kiyota, Ryohei Sasaki, Ken-Ichi Nibu.　Head Neck. 2023 Oct: 45(10):2498-2504. DOI: 10.1002/hed.27461 PMID: 37503962
• Impact of intratumoral microbiome on tumor immunity and prognosis in human pancreatic ductal adenocarcinoma.　 Shohei Abe, Atsuhiro Masuda, Tomonori Matsumoto, Jun Inoue, Hirochika Toyama, Arata Sakai, Takashi Kobayashi, Takeshi Tanaka, Masahiro Tsujimae, Kohei Yamakawa, Masanori Gonda, Shigeto Masuda, Hisahiro Uemura, Shinya Kohashi, Noriko Inomata, Kae Nagao, Yoshiyuki Harada, Mika Miki, Yosuke Irie, Noriko Juri, Testuhisa Ko, Yusuke Yokotani, Yuki Oka, Shogo Ota, Maki Kanzawa, Tomoo Itoh, Toshio Imai, Takumi Fukumoto, Eiji Hara, Yuzo Kodama.　J Gastroenterol. 2024 Mar: 59(3) :250-262. DOI: 10.1007/s00535-023-02069-5 PMID: 38242997
• Histological diagnosis of polyploidy discriminates an aggressive subset of hepatocellular carcinomas with poor prognosis.　Takanori Matsuura, Yoshihide Ueda, Yoshiyuki Harada, Kazuki Hayashi, Kisara Horisaka, Yoshihiko Yano, Shinichi So, Masahiro Kido, Takumi Fukumoto, Yuzo Kodama, Eiji Hara, Tomonori Matsumoto.　 Br J Cancer. 2023 Oct: 129(8):1251-1260. DOI: 10.1038/s41416-023-02408-6 PMID: 37715023

感染症×再生医学

• Blockage of retinoic acid signaling via RARγ suppressed the proliferation of pancreatic cancer cells by arresting the cell cycle progression of the G1-S phase.　 Kohei Yamakawa, Michiyo Koyanagi-Aoi, Akihito Machinaga, Nobuyuki Kakiuchi, Tomonori Hirano, Yuzo Kodama, Takashi Aoi.　Cancer Cell Int. 2023 May: 23(1):94. DOI: 10.1186/s12935-023-02928-4 PMID: 37198667