主要論文一覧(R５度)

センターメンバーにはアンダーライン

難治性がん　Intractable Cancers

• Michiko Itoh, Atsushi Tamura, Sayaka Kanai, Miyako Tanaka, Yohei Kanamori, Ibuki Shirakawa, Ayaka Ito, Yasuyoshi Oka, Isao Hidaka, Taro Takami, Yasushi Honda, Mitsuyo Maeda, Yasuyuki Saito, Yoji Murata, Takashi Matozaki, Atsushi Nakajima, Yosky Kataoka, Tomoo Ogi, Yoshihiro Ogawa, Takayoshi Suganami. Lysosomal cholesterol overload in macrophages promotes liver fibrosis in a mouse model of NASH.　 J Exp Med. 2023 Nov: 220(11):e20220681. DOI: 10.1084/jem.20220681 PMID: 37725372
• Mitsuharu Endo, Yuki Tanaka, Mayo Fukuoka, Hayata Suzuki, Yasuhiro Minami. Wnt5a/Ror2 promotes Nrf2‐mediated tissue protective function of astrocytes after brain injury. Glia. 2023 Oct: 72(2) 411-432 DOI: 10.1002/glia.24483 PMID: 37904612
• Michiru Nishita, Koki Kamizaki, Kyoka Hoshi, Kana Aruga, Ikumi Nishikaku, Hiroshi Shibuya, Kunio Matsumoto,Yasuhiro Minami.　 Rho family small GTPase Rif regulates Wnt5a-Ror1-Dvl2 signaling and promotes lung adenocarcinoma progression. J Biol Chem. 2023 Oct: 299(10):105248-105248. DOI: 10.1016/j.jbc.2023.105248 PMID: 37703992
• Ryosuke Takahashi, Koki Kamizaki, Keitaro Yamanaka, Yoshito Terai,Yasuhiro Minami.　 Expression of Ferredoxin1 in cisplatin resistant ovarian cancer cells confers their resistance against ferroptosis induced by cisplatin. Oncol. Rep. 2023 Jun: 49(6):124. DOI: 10.3892/or.2023.8561 PMID: 37144519
• Jing Pu, Satoshi Kofuji, Yoshimi Okamoto-Uchida, Keiko Danzaki, Ruoxing Yu, Akira Suzuki, Satoshi Kitajima, Hiroshi Nishina.　 Lethal Phenotype-Based Database Screening Identifies Ceramide as a Negative Regulator of Primitive Streak Formation.　 Stem Cells. 2023 Dec 41(12):1142-1156. DOI:10.1093/stmcls/sxad071. PMID: 37819786
• Kotaro Sato, Ming Yang, Kae Nakamura, Hiromasa Tanaka, Masaru Hori, Miki Nishio, Akira Suzuki, Hideharu Hibi, Shinya Toyokuni.　 Ferroptosis induced by plasma-activated Ringer's lactate solution prevents oral cancer progression.　 Oral Dis. 2023 Dec: DOI: 10.1111/odi.14827 PMID: 38047766
• Yuki Yamamoto, Tomonori Kamiya, Megumu Yano, Vu Thuong Huyen, Masahiro Oishi, Miki Nishio, Akira Suzuki, Kishiko Sunami, Naoko Ohtani.　 Oral Microbial Profile Analysis in Patients with Oral and Pharyngeal Cancer Reveals That Tumoral Fusobacterium nucleatum Promotes Oral Cancer Progression by Activating YAP. Microorganisms. 2023 Dec: 11(12):2957. DOI: 10.3390/microorganisms11122957 PMID: 38138101
• Yuki Azumi, Yu-ichiro Koma, Shuichi Tsukamoto, Yu Kitamura, Nobuaki Ishihara, Keitaro Yamanaka, Takashi Nakanishi, Shoji Miyako, Satoshi Urakami, Kohei Tanigawa, Takayuki Kodama, Mari Nishio, Manabu Shigeoka, Yoshihiro Kakeji, Hiroshi Yokozaki.　 IFI16 Induced by Direct Interaction between Esophageal Squamous Cell Carcinomas and Macrophages Promotes Tumor Progression via Secretion of IL-1α.　 Cells 2023 Nov: 12(22):2603-2603. DOI: 10.3390/cells12222603 PMID: 37998338
• Yasuhiro Kodera, Kazuhiro Yoshida, Mitsugu Kochi, Takeshi Sano, Wataru Ichikawa, Yoshihiro Kakeji, Yu Sunakawa, Masahiro Takeuchi, Masashi Fujii.　 Addition of docetaxel to S－1 results in significantly superior 5-year survival outcomes in Stage III gastric cancer: a final report of the JACCRO GC-07 study.　Gastric cancer. 2023 Nov: 26(6):1063-1068. DOI:10.1007/s10120-023-01419-9 PMID: 37548812
• Satoru Matsuda, Yuko Kitagawa, Ryo Takemura, Jun Okui, Akihiko Okamura, Hirofumi Kawakubo, Manabu Muto, Yoshihiro Kakeji, Hiroya Takeuchi, Masayuki Watanabe, Yuichiro Doki. Real-world Evaluation of the Efficacy of Neoadjuvant DCF Over CF in Esophageal Squamous Cell Carcinoma: Propensity Score-matched Analysis From 85 Authorized Institutes for Esophageal Cancer in Japan. 　 Ann Surg. 2023 Jul: 278(1):e35-e42. DOI: 10.1097/SLA.0000000000005533 PMID: 35837977

代謝　Metabolism

• Hiromichi Okuma, Yumiko Saijo‐Hamano, Hiroshi Yamada, Aalaa Alrahman Sherif, Emi Hashizaki, Naoki Sakai, Takaaki Kato, Tsuyoshi Imasaki, Satoshi Kikkawa, Eriko Nitta, Miwa Sasai, Tadashi Abe, Fuminori Sugihara, Yoshimasa Maniwa, Hidetaka Kosako, Kohji Takei, Daron M. Standley, Masahiro Yamamoto, Ryo Nitta. Structural basis of Irgb6 inactivation by Toxoplasma gondii through the phosphorylation of switch I. 　 Genes Cells 2023 Nov :29(1): 17-38 .DOI: 10.1111/gtc.13080 PMID:37984375
• Shintaro Yamada, Toshiyuki Ko, Masamichi Ito, Tatsuro Sassa, Seitaro Nomura, Hiromichi Okuma, Mayuko Sato, Tsuyoshi Imasaki, Satoshi Kikkawa, Bo Zhang, Takanobu Yamada, Yuka Seki, Kanna Fujita, Manami Katoh, Masayuki Kubota, Satoshi Hatsuse, Mikako Katagiri, Hiromu Hayashi, Momoko Hamano, Norifumi Takeda, Hiroyuki Morita, Shuji Takada, Masashi Toyoda, Masanobu Uchiyama, Masashi Ikeuchi, Kiminori Toyooka, Akihiro Umezawa, Yoshihiro Yamanishi, Ryo Nitta, Hiroyuki Aburatani, Issei Komuro.　 TEAD1 trapping by the Q353R–Lamin A/C causes dilated cardiomyopathy.　 Sci. Adv. 2023 Apr: 9(15):eade7047. DOI: 10.1126/sciadv.ade7047 PMID: 37058558
• Toru Tanaka, Naoto Sasaki, Aga Krisnanda, Masakazu Shinohara, Hilman Zulkifli Amin, Sayo Horibe, Ken Ito, Motoaki Iwaya, Atsushi Fukunaga, Ken-Ichi Hirata , Yoshiyuki Rikitake.　Novel UV-B Phototherapy With a Light-Emitting Diode Device Prevents Atherosclerosis by Augmenting Regulatory T-Cell Responses in Mice.　 J of Am Heart Assoc. 2024 Jan; 13(2):e031639.DOI: 10.1161/JAHA.123.031639 PMID: 38214259
• Sayo Horibe, Takuo Emoto, Taiji Mizoguchi, Toru Tanaka, Shoji Kawauchi, Naoto Sasaki, Tomoya Yamashita, Koji Ikeda, Noriaki Emoto, Ken-Ichi Hirata, Yoshiyuki Rikitake. 　 Endothelial senescence alleviates cognitive impairment in a mouse model of Alzheimer's disease.　 Glia. 2024 Jan; 72(1) :51-68. DOI: 10.1002/glia.24461 PMID: 37610154
• Daichi Fujimoto, Masakazu Shinohara, Hiroyuki Kawamori, Takayoshi Toba, Shunsuke Kakizaki, Koichi Nakamura, Satoru Sasaki, Tomoyo Hamana, Hiroyuki Fujii, Yuto Osumi, Naomi Hayasaka, Shigenobu Kishino, Jun Ogawa, Ken-ichi Hirata, Hiromasa Otake.　 The relationship between unique gut microbiome-derived lipid metabolites and subsequent revascularization in patients who underwent percutaneous coronary intervention.　 Atherosclerosis. 2023 Jun: 375:1-8. DOI: 10.1016/j.atherosclerosis.2023.05.001 PMID : 37216727

脳こころ　Brain and Mind

• Kiyohide Usami, Riki Matsumoto, Anna Korzeniewska, Akihiro Shimotake, Masao Matsuhashi, Takuro Nakae, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Ryosuke Takahashi, Nathan E Crone, Akiko Ikeda.　 The dynamics of cortical interactions in visual recognition of object category: living vs non-living. 　Cereb Cortex. 2023 Apr: 33(9):5740-5750. DOI: 10.1093/cercor/bhac456 PMID: 36408645
• Christopher R.Cox, Timothy Rogers, Akihiro Shimotake, Takayuki Kikuchi, Takeharu Kunieda, Susumu Miyamoto, Tyosuke Takahashi, Riki Matsumoto, Akiko Ikeda Matthew A. Lambon Ralph.　 Representational similarity learning reveals a graded multidimensional semantic space in the human anterior temporal cortex. 　Imaging Neuroscience. 2024 Feb: 2 DOI:10.1162/imag_a_00093
• Kiminobu Okayama, Naotaka Usui, Takashi Matsudaira, Akihiko Kondo, Yasukiyo Araki, Norihiko Kawaguchi, Kazumi Matsuda, Takayasu Tottori, Kiyohito Terada, Riki Matsumoto, Yukitoshi Takahashi.　 Mesial temporal lobe epilepsy with amygdalar hamartoma-like lesion: Is it a distinct syndrome? 　Epilepsy Res. 2023 May: 192:107140. DOI:10.1016/j.eplepsyres.2023.107140 PMID : 37037096
• Hisayoshi Kubota, Kazuo Kunisawa, Bolati Wulaer, Masaya Hasegawa, Hitomi Kurahashi, Takatoshi Sakata, Hiroyuki Tezuka, Masanori Kugita, Shizuko Nagao, Taku Nagai, Tomoyuki Furuyashiki, Shuh Narumiya, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri.　 High salt induces cognitive impairment via the interaction of angiotensin II-AT₁ and prostaglandin E2-EP₁ systems.　Br J Pharmacol. 2023 Sep: 180(18):2393-2411.DOI: 10.1111/bph.16093 PMID: 37076133
• Shiho Kitaoka, Ayaka Tomohiro, Shinya Ukeshima, Keyue Liu, Hidenori Wake, Shinya H Kimura, Yasuhiko Yamamoto, Masahiro Nishibori, Tomoyuki Furuyashiki.　 Repeated Social Defeat Stress Induces HMGB1 Nuclear Export in Prefrontal Neurons, Leading to Social Avoidance in Mice. 　Cells. 2023 Jul: 12(13):1789. DOI: 10.3390/cells12131789 PMID: 37443823
• Takeshi Kaizuka, Takehiro Suzuki, Noriyuki Kishi, Kota Tamada, Manfred W Kilimann, Takehiko Ueyama, Masahiko Watanabe, Hideyuki Okano, Naoshi Dohmae, Tomomi Shimogori, Toru Takumi.　 Remodeling of the postsynaptic proteome in male mice and marmosets during synapse development.　 Nat. Commun. 2024 Mar: 15(1):2496. DOI: 10.1038/s41467-024-46529-9 PMID: 38548776
• Takeshi Kaizuka, Taisei Hirouchi, Takeo Saneyoshi, Toshihiko Shirafuji, Mark O Collins, Seth G N Grant, Yasunori Hayashi, Toru Takumi.　FAM81A is a postsynaptic protein that regulates the condensation of postsynaptic proteins via liquid-liquid phase separation.　 PLoS Biol. 2024 Mar: 22(3):e3002006-. DOI:10.1371/journal.pbio.3002006 PMID: 38452102
• Masaaki Sato, Nobuhiro Nakai, Shuhei Fujima, Katrina Y Choe, Toru Takumi.　 Social circuits and their dysfunction in autism spectrum disorder.　 Mol Psychiatry. 2023 Aug: 28(8):3194-3206. DOI: 10.1038/s41380-023-02201-0 PMID: 37612363
• Ikuo Otsuka, Hanga Galfalvy, Jia Guo, Masato Akiyama, Dan Rujescu, Gustavo Turecki, Akitoyo Hishimoto , J John Mann.　Mapping the genetic architecture of suicide attempt and suicide death using polygenic risk scores for clinically-related psychiatric disorders and traits.　 Psychol Med. 2023 Apr: 53(6):2689-2697.DOI: 10.1017/S0033291721004700 PMID: 37310312
• Takaki Tanifuji, Satoshi Okazaki, Ikuo Otsuka, Kentaro Mouri, Tadasu Horai, Ryota Shindo, Toshiyuki Shirai, Akitoyo Hishimoto.　Epigenetic clock analysis reveals increased plasma cystatin C levels based on DNA methylation in major depressive disorder. 　Psychiatry Res. 2023 Apr: 322:115103-115103. DOI: 10.1016/j.psychres.2023.115103 PMID: 36803907
• Yuichi Fujita, Yoichi Uozumi, Nobuyuki Akutsu, Takashi Sasayama, Eiji Kohmura.　 Delayed facial palsy after resection of vestibular schwannoma: does it influence long-term facial nerve functional outcomes? 　J Neurosurg. 2023 Dec: 140(6):1605-1613. DOI: 10.3171/2023.10.JNS231581 PMID: 38100764
• Yuichi Fujita, Yoichi Uozumi, Takashi Sasayama, Eiji Kohmura.　 Subclassification of Koos grade 4 vestibular schwannoma: insights into tumor morphology for predicting postoperative facial nerve function. 　J Neurosurg. 2023 Jul :1-11.DOI: 10.3171/2023.5.JNS23715 PMID: 37503933
• Takashi Nakamura, Hirofumi Sakaguchi, Hiroaki Mohri, Yuzuru Ninoyu, Akihiro Goto, Taro Yamaguchi, Yoshitaka Hishikawa, Michiyuki Matsuda, Naoki Saito, Takehiko Ueyama.　 Dispensable role of Rac1 and Rac3 after cochlear hair cell specification.　 J. Mol. Med. 2023 Jul 101(7):843-854. DOI:10.1007/s00109-023-02317-4 PMID: 37204479
• Shunkou Kurasawa, Hiroaki Mohri, Keiji Tabuchi,Takehiko Ueyama.　 Loss of synaptic ribbons is an early cause in ROS-induced acquired sensorineural hearing loss.　 Neurobiol. Dis. 2023 Oct: 186:106280. DOI:10.1016/j.nbd.2023.106280 PMID: 37666363
• Anna R Docherty, Niamh Mullins, Allison E Ashley-Koch, Xuejun Qin, Jonathan R I Coleman, Andrey Shabalin, JooEun Kang, Balasz Murnyak, Frank Wendt, Mark Adams, Adrian I Campos, Emily DiBlasi, Janice M Fullerton, Henry R Kranzler, Amanda V Bakian, Eric T Monson, Miguel E Rentería, Consuelo Walss-Bass, Ole A Andreassen, Chittaranjan Behera, Cynthia M Bulik, Howard J Edenberg, Ronald C Kessler, J John Mann, John I Nurnberger Jr, Giorgio Pistis, Fabian Streit, Robert J Ursano, Renato Polimanti, Michelle Dennis, Melanie Garrett, Lauren Hair, Philip Harvey, Elizabeth R Hauser, Michael A Hauser, Jennifer Huffman, Daniel Jacobson, Ravi Madduri, Benjamin McMahon, David W Oslin, Jodie Trafton, Swapnil Awasthi, Wade H Berrettini, Martin Bohus, Xiao Chang, Hsi-Chung Chen, Wei J Chen, Erik D Christensen, Scott Crow, Philibert Duriez, Alexis C Edwards, Fernando Fernández-Aranda, Hanga Galfalvy, Michael Gandal, Philip Gorwood, Yiran Guo, Jonathan D Hafferty, Hakon Hakonarson, Katherine A Halmi, Akitoyo Hishimoto, Sonia Jain, Stéphane Jamain, Susana Jiménez-Murcia, Craig Johnson, Allan S Kaplan, Walter H Kaye, Pamela K Keel, James L Kennedy, Minsoo Kim, Kelly L Klump, Daniel F Levey, Dong Li, Shih-Cheng Liao, Klaus Lieb, Lisa Lilenfeld, Christian R Marshall, James E Mitchell, Satoshi Okazaki, Ikuo Otsuka, Dalila Pinto, Abigail Powers, Nicolas Ramoz, Stephan Ripke, Stefan Roepke, Vsevolod Rozanov, Stephen W Scherer, Christian Schmahl, Marcus Sokolowski, Anna Starnawska, Michael Strober, Mei-Hsin Su, Laura M Thornton, Janet Treasure, Erin B Ware, Hunna J Watson, Stephanie H Witt, D Blake Woodside, Zeynep Yilmaz, Lea Zillich, Rolf Adolfsson, Ingrid Agartz, Martin Alda, Lars Alfredsson, Vivek Appadurai, María Soler Artigas, Sandra Van der Auwera, M Helena Azevedo, Nicholas Bass, Claiton H D Bau, Bernhard T Baune, Frank Bellivier, Klaus Berger, Joanna M Biernacka, Tim B Bigdeli, Elisabeth B Binder, Michael Boehnke, Marco P Boks, David L Braff, Richard Bryant, Monika Budde, Enda M Byrne, Wiepke Cahn, Enrique Castelao, Jorge A Cervilla, Boris Chaumette, Aiden Corvin, Nicholas Craddock, Srdjan Djurovic, Jerome C Foo, Andreas J Forstner, Mark Frye, Justine M Gatt, Ina Giegling, Hans J Grabe, Melissa J Green, Eugenio H Grevet, Maria Grigoroiu-Serbanescu, Blanca Gutierrez, Jose Guzman-Parra, Marian L Hamshere, Annette M Hartmann, Joanna Hauser, Stefanie Heilmann-Heimbach, Per Hoffmann, Marcus Ising, Ian Jones, Lisa A Jones, Lina Jonsson, René S Kahn, John R Kelsoe, Kenneth S Kendler, Stefan Kloiber, Karestan C Koenen, Manolis Kogevinas, Marie-Odile Krebs, Mikael Landén, Marion Leboyer, Phil H Lee, Douglas F Levinson, Calwing Liao, Jolanta Lissowska, Fermin Mayoral, Susan L McElroy, Patrick McGrath, Peter McGuffin, Andrew McQuillin, Divya Mehta, Ingrid Melle, Philip B Mitchell, Esther Molina, Gunnar Morken, Caroline Nievergelt, Markus M Nöthen, Michael C O'Donovan, Roel A Ophoff, Michael J Owen, Carlos Pato, Michele T Pato, Brenda W J H Penninx, James B Potash, Robert A Power, Martin Preisig, Digby Quested, Josep Antoni Ramos-Quiroga, Andreas Reif, Marta Ribasés, Vanesa Richarte, Marcella Rietschel, Margarita Rivera, Andrea Roberts, Gloria Roberts, Guy A Rouleau, Diego L Rovaris, Alan R Sanders, Peter R Schofield, Thomas G Schulze, Laura J Scott, Alessandro Serretti, Jianxin Shi, Lea Sirignano, Pamela Sklar, Olav B Smeland, Jordan W Smoller, Edmund J S Sonuga-Barke, Maciej Trzaskowski, Ming T Tsuang, Gustavo Turecki, Laura Vilar-Ribó, John B Vincent, Henry Völzke, James T R Walters, Cynthia Shannon Weickert, Thomas W Weickert, Myrna M Weissman, Leanne M Williams, Naomi R Wray, Clement C Zai, Esben Agerbo, Anders D Børglum, Gerome Breen, Ditte Demontis, Annette Erlangsen, Joel Gelernter, Stephen J Glatt, David M Hougaard, Hai-Gwo Hwu, Po-Hsiu Kuo, Cathryn M Lewis, Qingqin S Li, Chih-Min Liu, Nicholas G Martin, Andrew M McIntosh, Sarah E Medland, Ole Mors, Merete Nordentoft, Catherine M Olsen, David Porteous, Daniel J Smith, Eli A Stahl, Murray B Stein, Danuta Wasserman, Thomas Werge, David C Whiteman, Virginia Willour, Hilary Coon, Jean C Beckham, Nathan A Kimbrel, Douglas M Ruderfer.　 GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors.　 The Am J Psychiatry. 2023 Oct: 180(10):723-738. DOI:10.1176/appi.ajp.21121266 PMID :37777856

感染症　Infectious Disease

• Umi Tahara, Takeshi Matsui, Toru Atsugi, Keitaro Fukuda, Tommy W Terooatea, Aki Minoda, Akiharu Kubo, Masayuki Amagai.　 Keratinocytes of the Upper Epidermis and Isthmus of Hair Follicles Express Hemoglobin mRNA and Protein.　J Invest Dermatol.　2023 Dec: 143(12):2346-2355. DOI: 10.1016/j.jid.2023.08.008 PMID: 37981423
• Yasuhiko Asahina, Umi Tahara, Satomi Aoki, Kazuhiko Nakabayashi, Chiharu Tateishi, Daisuke Hayashi, Masayuki Amagai, Daisuke Tsuruta, Akiharu Kubo.　 Two sporadic cases of childhood-onset Hailey-Hailey disease with superimposed mosaicism. 　 Eur J Hum Genet. 2023 Jan: 31(6):716-720. DOI: 10.1038/s41431-023-01316-w PMID: 36922631
• Tetsuya Yoshizaki, Yoshinobu Yamamoto, Tomoya Sako, Yasuaki Kitamura, Takayuki Ose, Tsukasa Ishida, Atsushi Ikeda, Ryusuke Ariyoshi, Mineo Iwatate, Fumiaki Kawara, Shinwa Tanaka, Toshitatsu Takao, Yoshinori Morita, Takashi Toyonaga, Yuzo Kodama.　 Outcomes of endoscopic submucosal dissection for esophageal cancer with segmental absence of intestinal musculature. 　 Gastrointest Endosc.　2023 Nov: DOI: 10.1016/j.gie.2023.11.007 PMID: 37952682
• Jing Rin Huang, Jun Arii, Mansaku Hirai, Mitsuhiro Nishimura, Yasuko Mori.　Human herpesvirus 6A nuclear matrix protein U37 interacts with heat shock transcription factor 1 and activates the heat shock response. 　J Virology 　2023 Sep: 97(9):e0071823-.DOI: 10.1128/jvi.00718-23 PMID: 37671864
• Silvia Sutandhio, Koichi Furukawa, Yukiya Kurahashi, Maria Istiqomah Marini, Gema Barlian Effendi, Natsumi Hasegawa, Hanako Ishimaru, Mitsuhiro Nishimura, Jun Arii, Yasuko Mori.　 Fourth mRNA vaccination increases cross-neutralizing antibody titers against SARS-CoV-2 variants, including BQ.1.1 and XBB, in a very elderly population. 　J Infect Public Health.　2023 Jul: 16(7):1064-1072. DOI:10.1016/j.jiph.2023.05.004 PMID: 37196370

再生医学　Regenerative Medicine

• Nobuyuki Murai, Michiyo Koyanagi-Aoi, Hiroto Terashi, Takashi Aoi.　 Re-generation of cytotoxic γδT cells with distinctive signatures from human γδT-derived iPSCs.　Stem Cell Reports　2023 Apr :18(4):853-868. DOI:10.1016/j.stemcr.2023.02.010 PMID: 36963392
• Yutaro Kanda, Kenichiro Kakutani, Yoshitada Sakai, Kunihiko Miyazaki, Tomoya Matsuo, Takashi Yurube, Yoshiki Takeoka, Hiroki Ohnishi, Masao Ryu, Naotoshi Kumagai, Kohei Kuroshima, Yoshiaki Hiranaka, Teruya Kawamoto, Hitomi Hara, Yuichi Hoshino, Shinya Hayashi, Toshihiro Akisue, Ryosuke Kuroda.　Clinical Characteristics and Surgical Outcomes of Metastatic Spine Tumors in the Very Elderly: A Prospective Cohort Study in a Super-Aged Society. 　J Clin Med.　2023 Jul: 12(14):4747. DOI: 10.3390/jcm12144747 PMID: 37510862
• Yutaro Kanda, Kenichiro Kakutani, Yoshitada Sakai, Takashi Yurube, Yoshiki Takeoka, Kunihiko Miyazaki, Hiroki Ohnishi, Tomoya Matsuo, Masao Ryu, Naotoshi Kumagai, Kohei Kuroshima, Yoshiaki Hiranaka, Ryosuke Kuroda.　 Clinical Characteristics, Surgical Outcomes, and Risk Factors for Emergency Surgery in Patients With Spinal Metastases: A Prospective Cohort Study. 　 Neurospine.　2024 Mar: 21(1): 314-327. DOI: 10.14245/ns.2347012.506 PMID: 38317551
• Bayu Pratama Putra, Keisuke Ito, Carla Cirillo, Mukhamad Sunardi, Haruhiko Koseki, Toshihiro Uesaka, Hideki Enomoto.　 Pcgf1 gene disruption reveals primary involvement of epigenetic mechanism in neuronal subtype specification in the enteric nervous system. 　Dev Growth Differ.　2023 Oct: 65(8): 461-469. DOI: 10.1111/dgd.12880 PMID: 37452641

創薬・医療機器　New Drug & Medical Device Development

• Tomoyuki Sakaue, Kazuhiro Yamamoto, Kotaro Itohara, Yumi Kitahiro, Takahito Endo, Naoki Yokoyama, Takeshi Ishimura, Tomohiro Omura, Ikuko Yano.　 Population pharmacokinetics of everolimus in renal transplant recipients receiving long-term multiple immunosuppressive therapy.　 Drug Metab Pharmacokinet.　2024 Epub 2024 Mar 12. DOI: 10.1016/j.dmpk.2024.101009 PMID: 38547661
• Takeshi Tomida, Kotaro Itohara, Kazuhiro Yamamoto, Takeshi Kimura, Kohei Fujita, Atsushi Uda, Yumi Kitahiro, Naoki Yokoyama, Yoji Hyodo, Tomohiro Omura, Ikuko Yano.　 A model-based pharmacokinetic assessment of drug–drug interaction between tacrolimus and nirmatrelvir/ritonavir in a kidney transplant patient with COVID-19.　 Drug Metab Pharmacokinet 　2023 Sep: DOI: 10.1016/j.dmpk.2023.100529 PMID: 37924724
• Hiroki Nishiguchi, Tomohiro Omura, Ayaka Sato, Yumi Kitahiro, Kazuhiro Yamamoto, Junichi Kunimasa, Ikuko Yano.　 Luteolin Protects Against 6-Hydoroxydopamine-Induced Cell Death via an Upregulation of HRD1 and SEL1L.　 Neurochem Research　 2024 Jan;49(1):117-128. DOI: 10.1007/s11064-023-04019-2 PMID: 37632637　Epub　2023 Aug
• Ryosuke Fujinaka, Shohei Komatsu, Kazuki Terashima, Yusuke Demizu, Satoshi Omiya, Masahiro Kido, Hirochika Toyama, Sunao Tokumaru, Tomoaki Okimoto, Takumi Fukumoto. Clinical impact of spacer placement surgery with expanded polytetrafluoroethylene sheet for particle therapy.　 Radiat Oncol.　2023 Oct: 18(1):173. DOI: 10.1186/s13014-023-02359-5 PMID: 37875956
• Tianyuan Wang, Keitaro Sofue, Ryuji Shimada, Takeaki Ishihara, Ryuichi Yada, Masanori Miyamoto, Ryohei Sasaki, Takamichi Murakami.　 Comparative study of sub-second temporal resolution 4D-MRI and 4D-CT for target motion assessment in a phantom model. 　Sci Rep.　2023 Sep: 13(1):15685-. DOI: 10.1038/s41598-023-42773-z PMID: 37735180
• Michael J Mauro, Timothy P Hughes, Dong-Wood Kim, Delpjome Réa, Jorge E Cortes, Andreas Hochhaus, Koji Sasaki, Massimo Breccia, Moshe Talpaz, Oliver Ottmann, Hironobu Minami, Yeow Tee Goh, Daniel J DeAngelo, Michael C Heinrich, Valle Gómez-García de Soria,　 Philipp Le Coutre, Francois-Xavier Mahon, Jeroen J W M Janssen, Michael Deininger, Naranie Shanmuganathan, Mark B Geyer, Silvia Cacciatore, Fotis Polydoros, Nithya Agrawal, Matthias Hoch, Fabian Lang.　Asciminib monotherapy in patients with CML-CP without BCR::ABL1 T315I mutations treated with at least two prior TKIs: 4-year phase 1 safety and efficacy results　 Leukemia.　2023 May: 37(5):1048-1059.　DOI: 10.1038/s41375-023-01860-w PMID: 36949155
• Noriko Fukuhara, Dai Maruyama, Kiyohito Hatake, Hirokazu Nagai, Shinichi Makita, Kenjiro Kamezaki, Toshiki Uchida, Shigeru Kusumoto, Junya Kuroda, Chisako Iriyama, Masamitsu Yanada, Norifumi Tsukamoto, Youko Suehiro, Hironobu Minami, Jose Garcia-Vargas, Barrett H Childs, Masanobu Yasuda, Shigeo Masuda, Toshiaki Tsujino, Yui Terao, Kensei Tobinai.　 Safety and antitumor activity of copanlisib in Japanese patients with relapsed/refractory indolent non-Hodgkin lymphoma: a phase Ib/II study.　Int J Hematol.　2023 Jan: 117(1):110-109. DOI:10.1007/s12185-022-03455-0 PMID: 36175779
• Kiyoaki Uryu, Yoshinori Imamura, Rai Shimoyama, Takahiro Mase, Yoshiaki Fujimura, Maki Hayashi, Megu Ohtaki, Keiko Otani, Makoto Hibino, Shigeto Horiuchi, Tomoya Fukui, Ryuta Fukai, Yusuke Chihara, Akihiko Iwase, Noriko Yamada, Yukihiro Tamura, Hiromasa Harada, Nobuaki Shinozaki, Asuka Tsuya, Masahiro Fukuoka, Hironobu Minami.　 Stepwise prolongation of overall survival from first to third generation EGFR-TKIs for EGFR mutation-positive non-small-cell lung cancer: the Tokushukai REAl-world Data project (TREAD 01) 　 Jpn J Clin Oncol.　2024 Mar: 54(3):319-328. DOI: 10.1093/jjco/hyad162 PMID: 37997468
• Shohei Komatsu, Tianyuan Wang, Kazuki Terashima, Yusuke Demizu, Makoto Anzai, Masaki Suga, Tomohiro Yamashita, Osamu Suzuki, Tomoaki Okimoto, Ryohei Sasaki, Takumi Fukumoto.　Innovative Combination Treatment to Expand the Indications of Particle Therapy: Spacer Placement Surgery Using Bio-Absorbable Polyglycolic Acid Spacer.　J Am Coll Surg.　 2024 Jan: 238(1):119-128. DOI:10.1097/XCS.0000000000000873 PMID: 37737669

感覚器プラットフォーム　Sensory Systems

• Mina Arai-Okuda, Yusuke Murai, Hidetaka Maeda, Akiyasu Kanamori, Takako Miki, Tomoko Naito, Kazunobu Sugihara, Michihiro Kono, Masaki Tanito, Hiromitsu Onoe, Kazuyuki Hirooka, Yoshiaki Kiuchi, Masakazu Shinohara, Sentaro Kusuhara, Sotaro Mori, Kaori Ueda, Mari Sakamoto, Yuko Yamada-Nakanishi, Makoto Nakamura.　Potentially compromised systemic and local lactate metabolic balance in glaucoma, which could increase retinal glucose and glutamate concentrations. 　Sci Rep.　2024 Feb: 14(1):3683-3683. DOI: 10.1038/s41598-024-54383-4 PMID: 38355836
• Mina Okuda, Sotaro Mori, Kaori Ueda, Mari Sakamoto, Sentaro Kusuhara, Yuko Yamada-Nakanishi, Makoto Nakamura.　 Favorable effect of ripasudil use on surgical outcomes of microhook ab interno trabeculotomy.　 Graefes Arc Clin Exp Ophthalmol.　2023 Sep : 261(9):2603-2610. DOI: 10.1007/s00417-023-06040-1 PMID: 37000272
• Makoto Nakamura, Mari Sakamoto, Kaori Ueda, Mina Okuda, Fumio Takano, Yuko Yamada-Nakanishi.　 Detection of Relative Afferent Pupillary Defect and Its Correlation with Structural and Functional Asymmetry in Patients with Glaucoma Using Hitomiru, a Novel Hand-Held Pupillometer. 　J Clin Med.　2023 Jun: 12(12):3936. DOI: 10.3390/jcm12123936 PMID: 37373631

難治性がん×創薬・医療機器

• Yasuyuki Saito, Rie Iida-Norita, Tania Afroj, Alaa Refaat, Daisuke Hazama, Satomi Komori, Shinya Ohata, Tomoko Takai, Okechi S. Oduori, Takenori Kotani, Yohei Funakoshi, Yu-Ichiro Koma, Yoji Murata, Kimikazu Yakushijin, Hiroshi Matsuoka, Hironobu Minami, Hiroshi Yokozaki, Markus G. Manz, Takashi Matozaki.　Preclinical evaluation of the efficacy of an antibody to human SIRPα for cancer immunotherapy in humanized mouse models　 Front Immunol.　2023 Dec: 14:1294814. DOI: 10.3389/fimmu.2023.1294814 PMID: 38162643

難治性がん×代謝

• Satomi Komori, Yasuyuki Saito, Taichi Nishimura, Datu Respatika, Hiromi Endoh, Hiroki Yoshida, Risa Sugihara, Rie Iida-Norita, Tania Afroj, Tomoko Takai, Okechi S. Oduori, Eriko Nitta, Takenori Kotani, Yoji Murata, Yoriaki Kaneko, Ryo Nitta, Hiroshi Ohnishi, Takashi Matozaki.　 CD47 promotes peripheral T cell survival by preventing dendritic cell–mediated T cell necroptosis.　Proc Natl Acad Sci U S A.　 2023 Aug: 120(33):e2304943120. DOI: 10.1073/pnas.2304943120 PMID: 37549290

代謝×脳こころ

• Makoto Nishimori, Naomi Hayasaka, Kazunori Otsui, Nobutaka Inoue, Manabu Nagao, Ryuji Toh, Tatsuro Ishida, Ken-ichi Hirata, Tomoyuki Furuyashiki, Masakazu Shinohara. 　Stress-induced stenotic vascular remodeling via reduction of plasma omega-3 fatty acid metabolite 4-oxoDHA by noradrenaline. 　Sci Rep.　2024 Feb: 14(1):4178. DOI: 10.1038/s41598-024-54867-3 PMID: 38378892

感染症×創薬・医療機器

• Akihiro Yamada, Hirotaka Shinomiya, Natsumi Uehara, Keisuke Iritani, Shun Tatehara, Tatsuya Furukawa, Masanori Teshima, Daisuke Miyawaki, Takeshi Fujita, Akinobu Kakigi, Naomi Kiyota, Ryohei Sasaki, Ken-Ichi Nibu.　 Oncological outcomes of concurrent chemoradiotherapy with docetaxel, cisplatin, and 5-fluorouracil for locally advanced squamous cell carcinoma of the external auditory canal: A single-center study.　 Head Neck.　 2023 Oct: 45(10):2498-2504. DOI: 10.1002/hed.27461 PMID: 37503962
• Shohei Abe, Atsuhiro Masuda, Tomonori Matsumoto, Jun Inoue, Hirochika Toyama, Arata Sakai, Takashi Kobayashi, Takeshi Tanaka, Masahiro Tsujimae, Kohei Yamakawa, Masanori Gonda, Shigeto Masuda, Hisahiro Uemura, Shinya Kohashi, Noriko Inomata, Kae Nagao, Yoshiyuki Harada, Mika Miki, Yosuke Irie, Noriko Juri, Testuhisa Ko, Yusuke Yokotani, Yuki Oka, Shogo Ota, Maki Kanzawa, Tomoo Itoh, Toshio Imai, Takumi Fukumoto, Eiji Hara, Yuzo Kodama.　 Impact of intratumoral microbiome on tumor immunity and prognosis in human pancreatic ductal adenocarcinoma.　J Gastroenterol.　2024 Mar: 59(3) :250-262. DOI: 10.1007/s00535-023-02069-5 PMID: 38242997　
• Takanori Matsuura, Yoshihide Ueda, Yoshiyuki Harada, Kazuki Hayashi, Kisara Horisaka, Yoshihiko Yano, Shinichi So, Masahiro Kido, Takumi Fukumoto, Yuzo Kodama, Eiji Hara, Tomonori Matsumoto.　 Histological diagnosis of polyploidy discriminates an aggressive subset of hepatocellular carcinomas with poor prognosis.　Br J Cancer.　 2023 Oct: 129(8):1251-1260. DOI: 10.1038/s41416-023-02408-6 PMID: 37715023

感染症×再生医学

• Kohei Yamakawa, Michiyo Koyanagi-Aoi, Akihito Machinaga, Nobuyuki Kakiuchi, Tomonori Hirano, Yuzo Kodama, Takashi Aoi.　 Blockage of retinoic acid signaling via RARγ suppressed the proliferation of pancreatic cancer cells by arresting the cell cycle progression of the G1-S phase.　Cancer Cell Int.　2023 May: 23(1):94. DOI: 10.1186/s12935-023-02928-4 PMID: 37198667