主要論文一覧(R４度)

難治性がん

• Yasuyuki Saito, Satomi Komori, Takenori Kotani, Yoji Murata, Takashi Matozaki The Role of Type-2 Conventional Dendritic Cells in the Regulation of Tumor Immunity Cancers. 2022 Apr13; 14(8):1976. doi: 10.3390/cancers14081976 PMID: 35454882
• Ryosuke Takahashi, Koki Kamizaki, Keitaro Yamanaka, Yoshito Terai, Yasuhiro Minami Expression of Ferredoxin1 in cisplatin resistant ovarian cancer cells confers their resistance against ferroptosis induced by cisplatin Oncology reports. 2023 Jun; 49(6):124. doi: 10.3892/or.2023.8561 PMID: 37144519
• Tomohiro Ishikawa, Yasuka Ogura, Kazuhiro Tanaka, Hiroaki Nagashima, Takashi Sasayama, Mitsuharu Endo, Yasuhiro Minami Ror1 is expressed inducibly by Notch and hypoxia signaling and regulates stem cell‐like property of glioblastoma cells Cancer Science. 2023 Feb; 114 (2):561 - 573. doi: 10.1111/cas.15630 PMID:36314076
• Takeshi Saji, Michiru Nishita, Kazuho Ikeda, Mitsuharu Endo, Yasushi Okada, Yasuhiro Minami c-Src-mediated phosphorylation and activation of kinesin KIF1C promotes elongation of invadopodia in cancer cells Journal of Biological Chemistry. 2022 Jul; 298(7): 102090. doi: 10.1016/j.jbc.2022.102090 PMID: 35654143
• Shuichi Tsukamoto, Yu-ichiro Koma, Yu Kitamura, Kohei Tanigawa, Yuki Azumi, Shoji Miyako, Satoshi Urakami, Masayoshi Hosono, Takayuki Kodama, Mari Nishio, Manabu Shigeoka, Hiroshi Yokozaki Matrix Metalloproteinase 9 Induced in Esophageal Squamous Cell Carcinoma Cells via Close Contact with Tumor-Associated Macrophages Contributes to Cancer Progression and Poor Prognosis Cancers. 2023 May; 15(11): 2987. doi: 10.3390/cancers15112987 PMID:37296952
• Yu Kitamura, Yu-ichiro Koma, Kohei Tanigawa, Shuichi Tsukamoto, Yuki Azumi, Shoji Miyako, Satoshi Urakami, Takayuki Kodama, Mari Nishio, Manabu Shigeoka, Yoshihiro Kakeji, Hiroshi Yokozaki Roles of IL-7R Induced by Interactions between Cancer Cells and Macrophages in the Progression of Esophageal Squamous Cell Carcinoma Cancers. 2023 Jan; 15(2): 394. doi: 10.3390/cancers15020394 PMID:36672342
• Takayuki Kodama, Manabu Shigeoka, Mari Nishio, Yu‐ichiro Koma, Masaya Akashi, Hiroshi Yokozaki Significance of intratumoural CD163+ macrophages in oral malignant melanoma: A preliminary study Oral Diseases. 2023 Jul; 29(5): 2061-2065. doi: 10.1111/odi.14252 PMID: 35567533
• Shigeo Hisamori, Junko Mukohyama, Sanjay Koul, Takanori Hayashi, Michael Evan Rothenberg, Masao Maeda, Taichi Isobe, Luis Enrique Valencia Salazar, Xin Qian, Darius Michael Johnston, Dalong Qian, Kaiqin Lao, Naoya Asai, Yoshihiro Kakeji, Vincenzo Alessandro Gennarino, Debashis Sahoo, Piero Dalerba, Yohei Shimono Upregulation of BMI1-suppressor miRNAs (miR-200c, miR-203) during terminal differentiation of colon epithelial cells. Journal of gastroenterology 2022 Jun; 57(6): 407-422. doi: 10.1007/s00535-022-01865-9 PMID: 35244768
• Daiki Okamoto, Natsuko Yamauchi, Gosuke Takiguchi, Michiru Nishita, Yoshihiro Kakeji, Yasuhiro Minami, Koki Kamizaki Autonomous and intercellular chemokine signaling elicited from mesenchymal stem cells regulates migration of undifferentiated gastric cancer cells Genes to cells: devoted to molecular & cellular mechanisms. 2022 May; 27(5): 368-375. doi: 10.1111/gtc.12933 PMID: 35261108
• Kaori Kanemaru, Makoto Shimozawa, Manabu Kitamata, Rikuto Furuishi, Hinako Kayano, Yui Sukawa, Yuuki Chiba, Takatsugu Fukuyama, Junya Hasegawa, Hiroki Nakanishi, Takuma Kishimoto, Kazuya Tsujita, Kazuma Tanaka, Toshiki Itoh, Junko Sasaki, Takehiko Sasaki, Kiyoko Fukami, Yoshikazu Nakamura Plasma membrane phosphatidylinositol (4,5)-bisphosphate is critical for determination of epithelial characteristics Nature Communications. 2022 May 9; 13(1):2347. doi: 10.1038/s41467-022-30061-9 PMID: 35534464
• Shinya Yuge, Koichi Nishiyama, Yuichiro Arima, Yasuyuki Hanada, Eri Oguri-Nakamura, Sanshiro Hanada, Tomohiro Ishii, Yuki Wakayama, Urara Hasegawa, Kazuya Tsujita, Ryuji Yokokawa, Takashi Miura, Toshiki Itoh, Kenichi Tsujita, Naoki Mochizuki, Shigetomo Fukuhara Mechanical loading of intraluminal pressure mediates wound angiogenesis by regulating the TOCA family of F-BAR proteins Nature Communications. 2022 May 12; 13(1):2594. doi: 10.1038/s41467-022-30197-8 PMID: 35551172

代謝

• Shintaro Yamada, Toshiyuki Ko, Masamichi Ito, Tatsuro Sassa, Seitaro Nomura, Hiromichi Okuma, Mayuko Sato, Tsuyoshi Imasaki, Satoshi Kikkawa, Bo Zhang, Takanobu Yamada, Yuka Seki, Kanna Fujita, Manami Katoh, Masayuki Kubota, Satoshi Hatsuse, Mikako Katagiri, Hiromu Hayashi, Momoko Hamano, Norifumi Takeda, Hiroyuki Morita, Shuji Takada, Masashi Toyoda, Masanobu Uchiyama, Masashi Ikeuchi, Kiminori Toyooka, Akihiro Umezawa, Yoshihiro Yamanishi, Ryo Nitta, Hiroyuki Aburatani, Issei Komuro TEAD1 trapping by the Q353R–Lamin A/C causes dilated cardiomyopathy Science Advances. 2023 Apr; 9(15): eade7047. doi: 10.1126/sciadv.ade7047 PMID:37058558
• Shinya Taguchi, Juri Nakano, Tsuyoshi Imasaki, Tomoki Kita, Yumiko Saijo-Hamano, Naoki Sakai, Hideki Shigematsu, Hiromichi Okuma, Takahiro Shimizu, Eriko Nitta, Satoshi Kikkawa, Satoshi Mizobuchi, Shinsuke Niwa, Ryo Nitta Structural model of microtubule dynamics inhibition by kinesin-4 from the crystal structure of KLP-12 –tubulin complex eLife. 2022 Sept 6; 11: e77877. doi: 10.7554/elife.77877 PMID: 36065637
• Tsuyoshi Imasaki, Satoshi Kikkawa, Shinsuke Niwa, Yumiko Saijo-Hamano, Hideki Shigematsu, Kazuhiro Aoyama, Kaoru Mitsuoka, Takahiro Shimizu, Mari Aoki, Ayako Sakamoto, Yuri Tomabechi, Naoki Sakai, Mikako Shirouzu, Shinya Taguchi, Yosuke Yamagishi, Tomiyoshi Setsu, Yoshiaki Sakihama, Eriko Nitta, Masatoshi Takeichi, Ryo Nitta CAMSAP2 organizes a γ-tubulin-independent microtubule nucleation centre through phase separation eLife. 2022 Jun; 11: e77362. doi: 10.7554/elife.77365 PMID: 35762204
• Yoshihiro Saito, Tomoya Yamashita, Naofumi Yoshida, Takuo Emoto, Shintaro Takeda, Tokiko Tabata, Masakazu Shinohara, Shigenobu Kishino, Yuta Sugiyama, Nahoko Kitamura, Hiroyuki Yamamoto, Tomofumi Takaya, Jun Ogawa, Ken-ichi Hirata Structural differences in bacterial lipopolysaccharides determine atherosclerotic plaque progression by regulating the accumulation of neutrophils Atherosclerosis. 2022 Oct; 358: 1-11. doi: 10.1016/j.atherosclerosis.2022.08.009 PMID:36049289
• Sachiko Yoshikawa, Manabu Nagao, Ryuji Toh, Masakazu Shinohara, Takuya Iino, Yasuhiro Irino, Makoto Nishimori, Hidekazu Tanaka, Seimi Satomi-Kobayashi, Tatsuro Ishida, Ken-Ichi Hirata Inhibition of glutaminase 1-mediated glutaminolysis improves pathological cardiac remodeling. American journal of physiology Heart and circulatory physiology. 2022 May 1; 322(5): H749-H761. doi: 10.1152/ajpheart.00692.2021 PMID: 35275762
• Ryohei Shinohara, Hitomi Nakashima, Takuo Emoto, Tomoya Yamashita, Yoshihiro Saito, Naofumi Yoshida, Taishi Inoue, Katsuhiro Yamanaka, Kenji Okada, Ken-Ichi Hirata Gut Microbiota Influence the Development of Abdominal Aortic Aneurysm by Suppressing Macrophage Accumulation in Mice.Hypertension (Dallas, Tex.: 1979). 2022 Dec; 79(12): 2821-2829. doi: 10.1161/HYPERTENSIONAHA.122.19422 PMID: 36252141

脳こころ

• Rei Mishima, Masayuki Taniguchi, Kazutoshi Matsushita, Bowen Tian, Tomoyuki Furuyashiki Microglial subpopulations with distinct transcriptome signatures vary across brain regions in the resting mouse brain. Journal of Pharmacological Sciences. 2023 Mar; 151(3): 142-147. doi: 10.1016/j.jphs.2022.12.010 PMID: 36828616 Epub 2022 Dec 29.
• Risa Sakate; Masahiro Nishiyama; Yu Fukuda; Shiho Kitaoka; Tomoyuki Furuyashiki The transcription factor Hhex regulates inflammation-related genes in microglia. J Pharmacol Sci. 2022 Jul; 149(3): -. doi: 10.1016/j.jphs.2022.04.006 PMID: 35641029
• Suhda S, Yamamoto Y, Wisesa S, Sada R, Sakisaka T The 14-3-3γ isoform binds to and regulates the localization of endoplasmic reticulum (ER) membrane protein TMCC3 for the reticular network of the ER. Journal of Biological Chemistry. 2023 Feb; 299(2): -. doi: 10.1016/j.jbc.2022.102813 PMID: 36549645
• Atsushi Hara, Norio Chihara, Ritsu Akatani, Ryusei Nishigori, Asato Tsuji, Hajime Yoshimura, Michi Kawamoto, Yoshihisa Otsuka, Yasufumi Kageyama, Takayuki Kondo, Frank Leypoldt, Klaus-Peter Wandinger, Riki Matsumoto Circulating plasmablasts and follicular helper T-cell subsets are associated with antibody-positive autoimmune epilepsy. Frontiers in Immunology. 2022 Dec 8; 13: 1048428. doi: 10.3389/fimmu.2022.1048428 PMID: 36569937
• Shusuke Koto, Norio Chihara, Ritsu Akatani, Hiroko Nakano, Atsushi Hara, Kenji Sekiguchi, Riki Matsumoto, Tatsushi Toda Transcription Factor c-Maf Promotes Immunoregulation of Programmed Cell Death 1-Expressed CD8+ T Cells in Multiple Sclerosis Neurology® Neuroimmunology & Neuroinflammation. 2022 Apr 5; 9(4): e1166. doi: 10.1212/NXI.0000000000001166 PMID: 35383094
• Togo M, Matsumoto R, Usami K, Kobayashi K, Takeyama H, Nakae T, Shimotake A, Kikuchi T, Yoshida K, Matsuhashi M, Kunieda T, Miyamoto S, Takahashi R, Ikeda A. Distinct connectivity patterns in human medial parietal cortices: Evidence from standardized connectivity map using cortico-cortical evoked potential. Neuroimage 2022 Nov; 263: 119639. doi: 10.1016/j.neuroimage.2022.119639. PMID: 36155245
• Nobuhiro Nakai, Masaaki Sato, Okito Yamashita, Yukiko Sekine, Xiaochen Fu, Junichi Nakai, Andrew Zalesky, Toru Takumi Virtual reality-based real-time imaging reveals abnormal cortical dynamics during behavioral transitions in a mouse model of autism. Cell reports. 2023 Mar; 112258. doi: 10.1016/j.celrep.2023.112258 PMID: 36990094
• Chia-Wen Lin, Jacob Ellegood, Kota Tamada, Ikuo Miura, Mikiko Konda, Kozue Takeshita, Koji Atarashi, Jason P Lerch, Shigeharu Wakana, Thomas J McHugh, Toru Takumi An old model with new insights: endogenous retroviruses drive the evolvement toward ASD susceptibility and hijack transcription machinery during development Molecular psychiatry. 2023 Mar 7. doi: 10.1038/s41380-023-01999-z PMID: 36882500
• Chia-Wen Lin, Dian E Septyaningtrias, Hsu-Wen Chao, Mikiko Konda, Koji Atarashi, Kozue Takeshita, Kota Tamada, Jun Nomura, Yohei Sasagawa, Kaori Tanaka, Itoshi Nikaido, Kenya Honda, Thomas J McHugh, Toru Takumi A common epigenetic mechanism across different cellular origins underlies systemic immune dysregulation in an idiopathic autism mouse model. Molecular psychiatry. 2022 Aug; 27(8): 3343-3354. doi: 10.1038/s41380-022-01566-y PMID: 35491410
• Takashi Nakamura, Hirofumi Sakaguchi, Hiroaki Mohri, Yuzuru Ninoyu, Akihiro Goto, Taro Yamaguchi, Yoshitaka Hishikawa, Michiyuki Matsuda, Naoaki Saito, Takehiko Ueyama Dispensable role of Rac1 and Rac3 after cochlear hair cell specification Journal of Molecular Medicine. 2023 Jul; 101(7): 843-854. doi: 10.1007/s00109-023-02317-4 PMID: 37204479
• Yoko Niki, Naoko Adachi, Masaki Fukata, Yuko Fukata, Shinichiro Oku, Chieko Makino-Okamura, Seiji Takeuchi, Kazumasa Wakamatsu, Shosuke Ito, Lieve Declercq, Daniel B Yarosh, Tomas Mammone, Chikako Nishigori, Naoaki Saito, Takehiko Ueyama S-Palmitoylation of Tyrosinase at Cysteine500 Regulates Melanogenesis. The Journal of investigative dermatology. 2023 Feb; 143(2): 317-327. doi: 10.1016/j.jid.2022.08.040 PMID: 36063887
• Bong Jik Kim, Takushi Miyoshi, Taimur Chaudhry, Thomas B Friedman, Byung Yoon Choi, Takehiko Ueyama Late-onset hearing loss case associated with a heterozygous truncating variant of DIAPH1. Clinical genetics. 2022 Apr; 101(4): 466-471. doi: 10.1111/cge.14115 PMID: 35060117
• Haruhi Encho, Kazuaki Uchida, Junya Nakamura, Sachiko Mizuta, Toshihiro Akisue, Hisatomo Kowa, Rei Ono Association between locomotive syndrome and anemia among community-dwelling older adults Geriatrics & gerontology international. 2023 Jun; 23(6): 426-429. doi: 10.1111/ggi.14593 PMID: 37165517
• Ryoko Kumagai, Tohmi Osaki, Yutaro Oki, Shunsuke Murata, Kazuaki Uchida, Haruhi Encho, Rei Ono, Hisatomo Kowa The Japan-Multimodal Intervention Trial for Prevention of Dementia PRIME Tamba (J-MINT PRIME Tamba): Study protocol of a randomised controlled multi-domain intervention trial Archives of Gerontology and Geriatrics. 2023 Jan; 104: 104803. doi: 10.1016/j.archger.2022.104803 PMID:36088747
• Hisatomo Kowa, Maki Uchimura, Asuka Ohashi, Mamoru Hiroe, Rei Ono Self Assessment Memory Scale (SAMS), a new simple method for evaluating memory function Frontiers in aging neuroscience. 2022 Nov 22; 14: 1024497-1024497. doi: 10.3389/fnagi.2022.1024497 PMID: 36483113

感染症

• Yasuhiko Asahina, Umi Tahara, Satomi Aoki, Kazuhiko Nakabayashi, Chiharu Tateishi, Daisuke Hayashi, Masayuki Amagai, Daisuke Tsuruta, Akiharu Kubo Two sporadic cases of childhood-onset Hailey-Hailey disease with superimposed mosaicism. European journal of human genetics. 2023 Jun; 31(6): 716-720. doi: 10.1038/s41431-023-01316-w PMID: 36922631 Epub 2023 Mar 15
• Sonoko Saito, Noriko Ono, Takashi Sasaki, Satomi Aoki, Kenjiro Kosaki, Bunya Kuze, Kazuhiko Nakabayashi, Masayuki Amagai, Akiharu Kubo Neurofibromatosis type 2 with mild Pierre-Robin sequence showing a heterozygous chromosome 22q12 microdeletion encompassing NF2 and MN1. Journal of human genetics. 2022 Nov; 67(11): 675-678. doi: 10.1038/s10038-022-01068-3 PMID: 35970985
• Ai Yoshioka, Makoto Kunisada, Hitoshi Fukuda, Akiharu Kubo Autoimmune progesterone dermatitis treated with dienogest: A case report. The Journal of dermatology. 2022 Oct; 49(10): e391-2392. doi: 10.1111/1346-8138.16445 PMID: 35587696
• Salma Aktar, Jun Arii, Thi Thu Huong Nguyen, Jing Rin Huang, Mitsuhiro Nishimura, Yasuko Mori ATF1 Restricts Human Herpesvirus 6A Replication via Beta Interferon Induction. Journal of virology. 2022 Oct 12; 96(19): e0126422. doi: 10.1128/jvi.01264-22 PMID: 36154610
• Yukiya Kurahashi, Koichi Furukawa, Silvia Sutandhio, Lidya Handayani Tjan, Sachiyo Iwata, Shigeru Sano, Yoshiki Tohma, Hiroyuki Ohkita, Sachiko Nakamura, Mitsuhiro Nishimura, Jun Arii, Tatsunori Kiriu, Masatsugu Yamamoto, Tatsuya Nagano, Yoshihiro Nishimura, Yasuko Mori Cross-neutralizing activity against Omicron could be obtained in SARS-CoV-2 convalescent patients who received two doses of mRNA vaccination. The Journal of infectious diseases. 2022 Oct 17; 226(8): 1391-1395. doi: 10.1093/infdis/jiac178 PMID: 35512332
• Koichi Furukawa, Lidya Handayani Tjan, Yukiya Kurahashi, Silvia Sutandhio, Mitsuhiro Nishimura, Jun Arii, Yasuko Mori Assessment of Neutralizing Antibody Response Against SARS-CoV-2 Variants After 2 to 3 Doses of the BNT162b2 mRNA COVID-19 Vaccine. JAMA network open. 2022 May; 5(5): e2210780. doi: 10.1001/jamanetworkopen.2022.10780 PMID: 35532938
• Laura Navika Yamani, Takako Utsumi, Yen Hai Doan, Yoshiki Fujii, Zayyin Dinana, Rury Mega Wahyuni, Emily Gunawan, Soegeng Soegijanto, Alpha Fardah Athiyyah, Subijanto Marto Sudarmo, Reza Gunadi Ranuh, Andy Darma, Soetjipto, Juniastuti, Rheza Gandi Bawono, Chieko Matsui, Lin Deng, Takayuki Abe, Hiroyuki Shimizu, Koji Ishii, Kazuhiko Katayama, Maria Inge Lusida, Ikuo Shoji Complete genome analyses of G12P [8] rotavirus strains from hospitalized children in Surabaya, Indonesia, 2017-2018. Journal of medical virology. 2023 Jan 10. doi: 10.1002/jmv.28485
• Putu Yuliandari, Chieko Matsui, Lin Deng, Takayuki Abe, Hiroyuki Mori, Shuhei Taguwa, Chikako Ono, Takasuke Fukuhara, Yoshiharu Matsuura, Ikuo Shoji Hepatitis C virus NS5A protein promotes the lysosomal degradation of diacylglycerol O-acyltransferase 1 (DGAT1) via endosomal microautophagy. Autophagy Reports. 2022 Jul; 1(1): 264-285. doi: 10.1080/27694127.2022.2095591
• Hiroshi Yamaguchi, Kandai Nozu, Hiroaki Hanafusa, Yoshinori Nambu, Takumi Kido, Atsushi Kondo, Akihiro Tamura, Hiroyuki Awano, Ichiro Morioka, Hiroaki Nagase, Akihito Ishida Impact after the Change from Voluntary to Universal Oral Rotavirus Vaccination on Consecutive Emergency Department Visits for Acute Gastroenteritis among Children in Kobe City, Japan (2016-2022). Vaccines. 2022 Oct; 10(11):1831. doi: 10.3390/vaccines10111831 PMID: 36366340
• Eri Okada, Naoya Morisada, Tomoko Horinouchi, Hideki Fujii, Takayuki Tsuji, Masayoshi Miura, Hideyuki Katori, Masashi Kitagawa, Kunio Morozumi, Takanobu Toriyama, Yuki Nakamura, Ryuta Nishikomori, Sadayuki Nagai, Atsushi Kondo, Yuya Aoto, Shinya Ishiko, Rini Rossanti, Nana Sakakibara, China Nagano, Tomohiko Yamamura, Shingo Ishimori, Joichi Usui, Kunihiro Yamagata, Kazumoto Iijima, Toshiyuki Imasawa, Kandai Nozu Detecting MUC1 Variants in Patients Clinicopathologically Diagnosed With Having Autosomal Dominant Tubulointerstitial Kidney Disease. Kidney international reports. 2022 Jan 4; 7(4): 857-866. doi: 10.1016/j.ekir.2021.12.037 PMID: 35497811 eCollection 2022 Apr.
• Siti Qamariyah Khairunisa, Ni Luh Ayu Megasari, Shuhei Ueda, Tomohiro Kotaki, Afif Nurul Hidayati, - Nasronudin, Masanori Kameoka Subtype distribution and drug resistance patterns among HIV-1 strains prevalent in Makassar, Indonesia. AIDS research and human retroviruses. 2023 Mar; 39(3): 124-129. doi: 10.1089/AID.2022.0139 PMID: 36656663
• Tomohiro Kotaki, Yurie Nagai, Atsushi Yamanaka, Eiji Konishi, Masanori Kameoka Japanese Encephalitis DNA Vaccines with Epitope Modification Reduce the Induction of Cross-Reactive Antibodies against Dengue Virus and Antibody-Dependent Enhancement of Dengue Virus Infection. Vaccines. 2022 Aug; 10(9): 1411. doi: 10.3390/vaccines10091411 PMID: 36146489
• Masahiro Urushidani, Akira Kawayoshi, Tomohiro Kotaki, Keiichi Saeki, Yasuko Mori, Masanori Kameoka Inactivation of SARS-CoV-2 and influenza A virus by dry fogging hypochlorous acid solution and hydrogen peroxide solution. PloS one. 2022 Apr 7; 17(4): e0261802. doi: 10.1371/journal.pone.0261802 PMID: 35389997

再生医学

• Masahiro Fujita, Tomoyuki Matsumoto, Shinya Hayashi, Shingo Hashimoto, Naoki Nakano, Toshihisa Maeda, Yuichi Kuroda, Yoshinori Takashima, Kenichi Kikuchi, Kensuke Anjiki, Kemmei Ikuta, Yuma Onoi, Shotaro Tachibana, Takehiko Matsushita, Hideki Iwaguro, Satoshi Sobajima, Takafumi Hiranaka, Ryosuke Kuroda Paracrine effect of the stromal vascular fraction containing M2 macrophages on human chondrocytes through the Smad2/3 signaling pathway. Journal of cellular physiology. 2022 Sept; 237(9): 3627-3639. doi: 10.1002/jcp.30823 PMID: 35766589
• Issei Shinohara, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Kohei Yamaura, Shintaro Mukohara, Tomoya Yoshikawa, Tatsuo Kato, Takahiro Furukawa, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda Biochemical Markers of Aging (Advanced Glycation End Products) and Degeneration Are Increased in Type 3 Rotator Cuff Tendon Stumps With Increased Signal Intensity Changes on MRI. The American journal of sports medicine. 2022 Jun; 50(7): 1960-1970. doi: 10.1177/03635465221090649 PMID: 35486520
• Nobuyuki Murai, Michiyo Koyanagi-Aoi, Hiroto Terashi, Takashi Aoi Re-generation of cytotoxic γδT cells with distinctive signatures from human γδT-derived iPSCs. Stem Cell Reports. 2023 Apr 11; 28(4): 853-868. doi: 10.1016/j.stemcr.2023.02.010 PMID: 36963392
• Mukhamad Sunardi, Keisuke Ito, Yuya Sato, Toshihiro Uesaka, Mitsuhiro Iwasaki, Hideki Enomoto A single RET mutation in Hirschsprung disease induces intestinal aganglionosis via a dominant-negative mechanism. Cellular and Molecular Gastroenterology and Hepatology. 2023: 15(6): 1505-1524. doi: 10.1016/j.jcmgh.2022.12.003 PMID: 36521661 Epub 2022 Dec 13.

創薬・医療機器

• Walaa Y B Mahdy, Kazuhiro Yamamoto, Takahiro Ito, Naoko Fujiwara, Kazumichi Fujioka, Tadasu Horai, Ikuo Otsuka, Hitomi Imafuku, Tomohiro Omura, Kazumoto Iijima, Ikuko Yano Physiologically-based pharmacokinetic model to investigate the effect of pregnancy on risperidone and paliperidone pharmacokinetics: Application to a pregnant woman and her neonate. Clinical and translational science. 2023 Apr; 16(4): 618-630. doi: 10.1111/cts.13473 PMID: 36655374 Epub 2023 Jan 19
• Takeshi Kimura, Misa Fujita, Michiko Shimizu, Kasumi Sumiyoshi, Saho Bansho, Kazuhiro Yamamoto, Tomohiro Omura, Ikuko Yano Effectiveness of pharmacist intervention for deprescribing potentially inappropriate medications: a prospective observational study. Journal of Pharmaceutical Health Care and Sciences. 2022 Apr; 8(1): 12. doi: 10.1186/s40780-022-00243-0 PMID: 35382881
• Kotaro Itohara, Ikuko Yano, Shunsaku Nakagawa, Mitsuhiro Sugimoto, Machiko Hirai, Atsushi Yonezawa, Satoshi Imai, Takayuki Nakagawa, Daiki Hira, Takashi Ito, Koichiro Hata, Etsuro Hatano, Tomohiro Terada, Kazuo Matsubara. Population pharmacokinetics of everolimus in adult liver transplant patients: Comparison to tacrolimus disposition and extrapolation to pediatrics. Clinical and Translational Science. 2022 Nov; 15(11): 2652-2662. doi: 10.1111/cts.13389 PMID: 36004935
• Jun Ishida, Hirochika Toyama, Sadaki Asari, Tadahiro Goto, Yoshihide Nanno, Takuya Mizumoto, Daisuke Tsugawa, Shohei Komatsu, Kaori Kuramitsu, Hiroaki Yanagimoto, Masahiro Kido, Takumi Fukumoto Use of a short cartridge stapler is beneficial in pancreatic transection at the neck during laparoscopic distal pancreatectomy. Surgery today. 2023 Jan; 53(1): 153-157. doi: 10.1007/s00595-022-02540-5 PMID: 35879473
• Yu Hashimoto, Shohei Komatsu, Kazuki Terashima, Daisuke Tsugawa, Hiroaki Yanagimoto, Masaki Suga, Yusuke Demizu, Sunao Tokumaru, Tomoaki Okimoto, Ryohei Sasaki, Tetsuo Ajiki, Takumi Fukumoto Space-making particle therapy for unresectable hilar cholangiocarcinoma. Digestive surgery. 2022; 39(2-3): 99-108. doi: 10.1159/000524582 PMID: 35462363
• Yamamoto N, Inoue R, Makino Y, Sekiguchi H, Shibayama N, Naito A, Sugiyama M, Chatani E. Tracking the Structural Development of Amyloid Precursors in the Insulin B Chain and the Inhibition Effect by Fibrinogen. J. Phys. Chem. B. 2022 Dec 29; 126(51): 10797-10812. doi: 10.1021/acs.jpcb.2c05136. PMID:36534755
• Mohammed Salah, Hiroaki Akasaka, Yasuyuki Shimizu, Kenta Morita, Yuya Nishimura, Hikaru Kubota, Hiroki Kawaguchi, Tomomi Sogawa, Naritoshi Mukumoto, Chiaki Ogino, Ryohei Sasaki Reactive oxygen species-inducing titanium peroxide nanoparticles as promising radiosensitizers for eliminating pancreatic cancer stem cells. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 2022 Apr 15; 41(1): 146. doi: 10.1186/s13046-022-02358-6 PMID: 35428310
• Marika Watanabe, Kimikazu Yakushijin, Yohei Funakoshi, Goh Ohji, Hiroya Ichikawa, Hironori Sakai, Wataru Hojo, Miki Saeki, Yuri Hirakawa, Sakuya Matsumoto, Rina Sakai, Shigeki Nagao, Akihito Kitao, Yoshiharu Miyata, Taiji Koyama, Yasuyuki Saito, Shinichiro Kawamoto, Katsuya Yamamoto, Mitsuhiro Ito, Tohru Murayama, Hiroshi Matsuoka, Hironobu Minami A Third Dose COVID-19 Vaccination in Allogeneic Hematopoietic Stem Cell Transplantation Patients. Vaccines. 2022 Oct 29; 10(11): 1830. doi: 10.3390/vaccines10111830 PMID: 36366338
• Yukinori Ozaki, Junji Tsurutani, Toru Mukohara, Tsutomu Iwasa, Masato Takahashi, Yuko Tanabe, Hidetaka Kawabata, Norikazu Masuda, Manabu Futamura, Hironobu Minami, Koji Matsumoto, Kenichi Yoshimura, Shigehisa Kitano, Toshimi Takano Safety and efficacy of nivolumab plus bevacizumab, paclitaxel for HER2-negative metastatic breast cancer: Primary results and biomarker data from a phase 2 trial (WJOG9917B). European journal of cancer (Oxford, England: 1990). 2022 Aug; 171: 193-202. doi: 10.1016/j.ejca.2022.05.014 PMID: 35728379
• Yoshinori Imamura, Kazunori Otsui, Kenta Mori, Koichi Kitagawa, Hideaki Okada, Akito Hata, Hidetoshi Hayashi, Taku Nose, Shinya Ohata, Yoshiharu Miyata, Yohei Funakoshi, Masanori Toyoda, Kimikazu Yakushijin, Naomi Kiyota, Hiroshi Matsuoka, Hironobu Minami Apixaban in Japanese patients with cancer-associated venous thromboembolism: a multi-center phase II trial. International journal of hematology. 2022 Apr; 115(4): 499-507. doi: 10.1007/s12185-022-03289-w PMID: 35079961

感覚器プラットフォーム

• Yoshiaki Kiuchi, Toshihiro Inoue, Nobuyuki Shoji, Makoto Nakamura, Masaki Tanito The Japan Glaucoma Society guidelines for glaucoma 5th edition. Japanese journal of ophthalmology. 2023 Mar; 67(2): 189-254. doi: 10.1007/s10384-022-00970-9 PMID: 36780040
• Yasuyuki Sotani, Hisanori Imai, Yukako Iwane, Tomohiro Yokogawa, Hiroko Yamada, Wataru Matsumiya, Akiko Miki, Sentaro Kusuhara, Makoto Nakamura INTRAOPERATIVE OPTICAL COHERENCE TOMOGRAPHY FOR REAL-TIME VISUALIZATION OF THE POSITIONAL RELATIONSHIP BETWEEN BUCKLING MATERIAL AND RETINAL BREAKS DURING SCLERAL BUCKLING FOR RHEGMATOGENOUS RETINAL DETACHMENT. Retina (Philadelphia, Pa.). 2022 Dec 1; 42(12): 2395-2400. doi: 10.1097/IAE.0000000000003610 PMID: 36394893

難治性がん×再生医学

• Takahiro Koide, Michiyo Koyanagi-Aoi, Keiichiro Uehara, Yoshihiro Kakeji, Takashi Aoi CDX2-induced intestinal metaplasia in human gastric organoids derived from induced pluripotent stem cells. iScience. 2022 Apr 28; 25(5): 104314. doi: 10.1016/j.isci.2022.104314 PMID: 35602937

難治性がん×創薬・医療機器

• Yusuke Shiraishi, Tomohiko Maehama, Miki Nishio, Junji Otani, Hiroki Hikasa, Tak Wah Mak, Takehiko Sasaki, Teruki Honma, Yasumitsu Kondoh, Hiroyuki Osada, Minoru Yoshida, Masato Fujisawa, Akira Suzuki N-(3,4-dimethoxyphenethyl)-6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-amine inhibits bladder cancer progression by suppressing YAP1/TAZ. GENES TO CELLS. 2022 Oct; 27(10): 602-612. doi: 10.1111/gtc.12979 PMID: 36054428
• Yuntao Dai, Tetsuya Kawaguchi, Miki Nishio, Junji Otani, Hironori Tashiro, Yoshito Terai, Ryohei Sasaki, Tomohiko Maehama, Akira Suzuki The TIGD5 gene located in 8q24 and frequently amplified in ovarian cancers is a tumor suppressor. GENES TO CELLS. 2022 Nov; 27(11):633-642. doi: 10.1111/gtc.12980 PMID: 36054307
• Hirotoshi Soyama, Miki Nishio, Junji Otani, Toshiko Sakuma, Shintaro Takao, Shigeo Hara, Takaaki Masuda, Koshi Mimori, Shinya Toyokuni, John P. Lydon, Kazuwa Nakao, Hiroshi Nishina, Takumi Fukumoto, Tomohiko Maehama, Akira Suzuki Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022 Jul 19; 119(29): e2123134119. doi: 10.1073/pnas.2123134119 PMID: 35858357

代謝×脳こころ

• Satoshi Akiyama, Hirotaka Nagai, Shota Oike, Io Horikawa, Masakazu Shinohara, Yabin Lu, Takashi Futamura, Ryota Shinohara, Shiho Kitaoka, Tomoyuki Furuyashiki Chronic social defeat stress increases the amounts of 12-lipoxygenase lipid metabolites in the nucleus accumbens of stress-resilient mice. Scientific Reports. 2022 Jul; 12(1): 11385. doi: 10.1038/s41598-022-15461-7 PMID: 35790870
• Takuo Emoto, Hiroyuki Yamamoto, Tomoya Yamashita, Tomofumi Takaya, Takahiro Sawada, Shintaro Takeda, Masayuki Taniguchi, Naoto Sasaki, Naofumi Yoshida, Yoshihiro Saito, Tharini Sivasubramaniyam, Hiromasa Otake, Tomoyuki Furuyashiki, Clinton S Robbins, Hiroya Kawai, Ken-Ichi Hirata Single-Cell RNA Sequencing Reveals a Distinct Immune Landscape of Myeloid Cells in Coronary Culprit Plaques Causing Acute Coronary Syndrome. Circulation. 2022 May 3; 145(18): 1434-1436. doi: 10.1161/CIRCULATIONAHA.121.058414 PMID: 35500048

代謝×感染症

• Yunlong Sui, Namiko Hoshi, Ryuichi Ohgaki, Lingling Kong, Ryutaro Yoshida, Norihiro Okamoto, Masato Kinoshita, Haruka Miyazaki, Yuna Ku, Eri Tokunaga, Yuki Ito, Daisuke Watanabe, Makoto Ooi, Masakazu Shinohara, Kengo Sasaki, Yoh Zen, Takenori Kotani, Takashi Matozaki, Zibin Tian, Yoshikatsu Kanai, Yuzo Kodama LAT1 expression influences Paneth cell number and tumor development in Apc^Min/+ mice. Journal of Gastroenterology. 2023 May; 58(5): 444 - 457. doi: 10.1007/s00535-023-01960-5 PMID: 36739585 Epub 2023 Feb 5.

代謝×再生医学

• Yu Hirata, Kazuhiro Nomura, Daisuke Kato, Yoshihisa Tachibana, Takahiro Niikura, Kana Uchiyama, Tetsuya Hosooka, Tomoaki Fukui, Keisuke Oe, Ryosuke Kuroda, Yuji Hara, Takahiro Adachi, Koji Shibasaki, Hiroaki Wake, Wataru Ogawa A Piezo1/KLF15/IL-6 axis mediates immobilization-induced muscle atrophy. The Journal of clinical investigation. 2022 May 16; 132(10): 1-13. doi: 10.1172/JCI154611 PMID: 35290243

感染症×創薬・医療機器

• Yohei Funakoshi, Kimikazu Yakushijin, Goh Ohji, Wataru Hojo, Hironori Sakai, Marika Watanabe, Akihito Kitao, Yoshiharu Miyata, Yasuyuki Saito, Shinichiro Kawamoto, Katsuya Yamamoto, Mitsuhiro Ito, Taiji Koyama, Yoshinori Imamura, Naomi Kiyota, Hiroshi Matsuoka, Yasuko Mori, Hironobu Minami Promising Efficacy of a Third Dose of mRNA SARS-CoV-2 Vaccination in Patients Treated with Anti-CD20 Antibody Who Failed 2-Dose Vaccination. Vaccines. 2022 Jun 17; 10(6): 965. doi: 10.3390/vaccines10060965 PMID: 35746573
• Takeshi Tanaka, Atsuhiro Masuda, Jun Inoue, Tsuyoshi Hamada, Takuya Ikegawa, Hirochika Toyama, Keitaro Sofue, Hideyuki Shiomi, Arata Sakai, Takashi Kobayashi, Shunta Tanaka, Ryota Nakano, Yasutaka Yamada, Shigeto Ashina, Masahiro Tsujimae, Kohei Yamakawa, Shohei Abe, Masanori Gonda, Shigeto Masuda, Noriko Inomata, Hisahiro Uemura, Shinya Kohashi, Kae Nagao, Maki Kanzawa, Tomoo Itoh, Yoshihide Ueda, Takumi Fukumoto, Yuzo Kodama Integrated analysis of tertiary lymphoid structures in relation to tumor-infiltrating lymphocytes and patient survival in pancreatic ductal adenocarcinoma. Journal of gastroenterology. 2023 Jan; 58(3): 277-291. doi: 10.1007/s00535-022-01939-8 PMID: 36705749

再生医学×創薬・医療機器

• Toshiyuki Takemori, Teruya Kawamoto, Hitomi Hara, Naomasa Fukase, Shuichi Fujiwara, Ikuo Fujita, Takuya Fujimoto, Masayuki Morishita, Kazumichi Kitayama, Shunsuke Yahiro, Tomohiro Miyamoto, Masanori Saito, Jun Sugaya, Katsuhiro Hayashi, Hiroyuki Kawashima, Tomoaki Torigoe, Tomoki Nakamura, Hiroya Kondo, Toru Wakamatsu, Munenori Watanuki, Munehisa Kito, Satoshi Tsukushi, Akihito Nagano, Hidetatsu Outani, Shunichi Toki, Shunji Nishimura, Hiroshi Kobayashi, Itsuo Watanabe, Yusuke Demizu, Ryohei Sasaki, Takumi Fukumoto, Takahiro Niikura, Ryosuke Kuroda, Toshihiro Akisue Clinical Outcome of Patients with Pelvic and Retroperitoneal Bone and Soft Tissue Sarcoma: A Retrospective Multicenter Study in Japan. Cancers. 2022 Jun 20; 14(12): 3023. doi: 10.3390/cancers14123023 PMID: 35740688
• Yuta Yoshioka, Yoshihisa Tachibana, Toshihiro Uesaka, Hiroyuki Hioki, Yuya Sato, Takumi Fukumoto, Hideki Enomoto Uts2b is a microbiota-regulated gene expressed in vagal afferent neurons connected to enteroendocrine cells producing cholecystokinin. Biochemical and biophysical research communications. 2022 Jun 11; 608: 66-72. doi: 10.1016/j.bbrc.2022.03.117 PMID: 35390674

感染症×再生医学×創薬・医療機器

• Kohei Yamakawa, Michiyo Koyanagi-Aoi, Keiichiro Uehara, Atsuhiro Masuda, Hiroaki Yanagimoto, Hirochika Toyama, Takumi Fukumoto, Yuzo Kodama, Takashi Aoi Increased expression of SPRR1A is associated with a poor prognosis in pancreatic ductal adenocarcinoma. PLOS ONE. 2022 May 26; 17(5): e0266620. doi: 10.1371/journal.pone.0266620 PMID: 35617311