主要論文一覧(R４度)

センターメンバーにはアンダーライン

難治性がん Intractable Cancers

• The Role of Type-2 Conventional Dendritic Cells in the Regulation of Tumor Immunity　 Yasuyuki Saito, Satomi Komori, Takenori Kotani, Yoji Murata, Takashi Matozaki　Cancers. 2022 Apr13; 14(8):1976. doi: 10.3390/cancers14081976 PMID: 35454882
• Expression of Ferredoxin1 in cisplatin resistant ovarian cancer cells confers their resistance against ferroptosis induced by cisplatin　 Ryosuke Takahashi, Koki Kamizaki, Keitaro Yamanaka, Yoshito Terai, Yasuhiro Minami Oncology reports. 2023 Jun; 49(6):124. doi: 10.3892/or.2023.8561 PMID: 37144519
• Ror1 is expressed inducibly by Notch and hypoxia signaling and regulates stem cell‐like property of glioblastoma cells 　Tomohiro Ishikawa, Yasuka Ogura, Kazuhiro Tanaka, Hiroaki Nagashima, Takashi Sasayama, Mitsuharu Endo, Yasuhiro Minami　 Cancer Science. 2023 Feb; 114 (2):561 - 573. doi: 10.1111/cas.15630 PMID:36314076
• c-Src-mediated phosphorylation and activation of kinesin KIF1C promotes elongation of invadopodia in cancer cells 　 Takeshi Saji, Michiru Nishita, Kazuho Ikeda, Mitsuharu Endo, Yasushi Okada, Yasuhiro Minami　Journal of Biological Chemistry. 2022 Jul; 298(7): 102090. doi: 10.1016/j.jbc.2022.102090 PMID: 35654143
• Matrix Metalloproteinase 9 Induced in Esophageal Squamous Cell Carcinoma Cells via Close Contact with Tumor-Associated Macrophages Contributes to Cancer Progression and Poor Prognosis 　 Shuichi Tsukamoto, Yu-ichiro Koma, Yu Kitamura, Kohei Tanigawa, Yuki Azumi, Shoji Miyako, Satoshi Urakami, Masayoshi Hosono, Takayuki Kodama, Mari Nishio, Manabu Shigeoka, Hiroshi Yokozaki Cancers. 2023 May; 15(11): 2987. doi: 10.3390/cancers15112987 PMID:37296952
• Roles of IL-7R Induced by Interactions between Cancer Cells and Macrophages in the Progression of Esophageal Squamous Cell Carcinoma 　Yu Kitamura, Yu-ichiro Koma, Kohei Tanigawa, Shuichi Tsukamoto, Yuki Azumi, Shoji Miyako, Satoshi Urakami, Takayuki Kodama, Mari Nishio, Manabu Shigeoka, Yoshihiro Kakeji, Hiroshi Yokozaki　Cancers.　2023 Jan; 15(2): 394. doi: 10.3390/cancers15020394 PMID:36672342
• Significance of intratumoural CD163+ macrophages in oral malignant melanoma: A preliminary study 　Takayuki Kodama, Manabu Shigeoka, Mari Nishio, Yu‐ichiro Koma, Masaya Akashi, Hiroshi Yokozaki Oral Diseases. 2023 Jul; 29(5): 2061-2065. doi: 10.1111/odi.14252 PMID: 35567533
• Upregulation of BMI1-suppressor miRNAs (miR-200c, miR-203) during terminal differentiation of colon epithelial cells.　 Shigeo Hisamori, Junko Mukohyama, Sanjay Koul, Takanori Hayashi, Michael Evan Rothenberg, Masao Maeda, Taichi Isobe, Luis Enrique Valencia Salazar, Xin Qian, Darius Michael Johnston, Dalong Qian, Kaiqin Lao, Naoya Asai, Yoshihiro Kakeji, Vincenzo Alessandro Gennarino, Debashis Sahoo, Piero Dalerba, Yohei Shimono Journal of gastroenterology 2022 Jun; 57(6): 407-422. doi: 10.1007/s00535-022-01865-9 PMID: 35244768
• Autonomous and intercellular chemokine signaling elicited from mesenchymal stem cells regulates migration of undifferentiated gastric cancer cells　 Daiki Okamoto, Natsuko Yamauchi, Gosuke Takiguchi, Michiru Nishita, Yoshihiro Kakeji, Yasuhiro Minami, Koki Kamizaki　Genes to cells: devoted to molecular & cellular mechanisms. 2022 May; 27(5): 368-375. doi: 10.1111/gtc.12933 PMID: 35261108
• Plasma membrane phosphatidylinositol (4,5)-bisphosphate is critical for determination of epithelial characteristics 　Kaori Kanemaru, Makoto Shimozawa, Manabu Kitamata, Rikuto Furuishi, Hinako Kayano, Yui Sukawa, Yuuki Chiba, Takatsugu Fukuyama, Junya Hasegawa, Hiroki Nakanishi, Takuma Kishimoto, Kazuya Tsujita, Kazuma Tanaka, Toshiki Itoh, Junko Sasaki, Takehiko Sasaki, Kiyoko Fukami, Yoshikazu Nakamura　Nature Communications. 2022 May 9; 13(1):2347. doi: 10.1038/s41467-022-30061-9 PMID: 35534464
• Mechanical loading of intraluminal pressure mediates wound angiogenesis by regulating the TOCA family of F-BAR proteins 　 Shinya Yuge, Koichi Nishiyama, Yuichiro Arima, Yasuyuki Hanada, Eri Oguri-Nakamura, Sanshiro Hanada, Tomohiro Ishii, Yuki Wakayama, Urara Hasegawa, Kazuya Tsujita, Ryuji Yokokawa, Takashi Miura, Toshiki Itoh, Kenichi Tsujita, Naoki Mochizuki, Shigetomo Fukuhara.　Nature Communications. 2022 May 12; 13(1):2594. doi: 10.1038/s41467-022-30197-8 PMID: 35551172

代謝　Metabolism

• TEAD1 trapping by the Q353R–Lamin A/C causes dilated cardiomyopathy 　Shintaro Yamada, Toshiyuki Ko, Masamichi Ito, Tatsuro Sassa, Seitaro Nomura, Hiromichi Okuma, Mayuko Sato, Tsuyoshi Imasaki, Satoshi Kikkawa, Bo Zhang, Takanobu Yamada, Yuka Seki, Kanna Fujita, Manami Katoh, Masayuki Kubota, Satoshi Hatsuse, Mikako Katagiri, Hiromu Hayashi, Momoko Hamano, Norifumi Takeda, Hiroyuki Morita, Shuji Takada, Masashi Toyoda, Masanobu Uchiyama, Masashi Ikeuchi, Kiminori Toyooka, Akihiro Umezawa, Yoshihiro Yamanishi, Ryo Nitta, Hiroyuki Aburatani, Issei Komuro　Science Advances. 2023 Apr; 9(15): eade7047. doi: 10.1126/sciadv.ade7047 PMID:37058558
• Structural model of microtubule dynamics inhibition by kinesin-4 from the crystal structure of KLP-12 –tubulin complex 　Shinya Taguchi, Juri Nakano, Tsuyoshi Imasaki, Tomoki Kita, Yumiko Saijo-Hamano, Naoki Sakai, Hideki Shigematsu, Hiromichi Okuma, Takahiro Shimizu, Eriko Nitta, Satoshi Kikkawa, Satoshi Mizobuchi, Shinsuke Niwa, Ryo Nitta >eLife. 2022 Sept 6; 11: e77877. doi: 10.7554/elife.77877 PMID: 36065637
• Tsuyoshi Imasaki, Satoshi Kikkawa, Shinsuke Niwa, Yumiko Saijo-Hamano, Hideki Shigematsu, Kazuhiro Aoyama, Kaoru Mitsuoka, Takahiro Shimizu, Mari Aoki, Ayako Sakamoto, Yuri Tomabechi, Naoki Sakai, Mikako Shirouzu, Shinya Taguchi, Yosuke Yamagishi, Tomiyoshi Setsu, Yoshiaki Sakihama, Eriko Nitta, Masatoshi Takeichi, Ryo Nitta CAMSAP2 organizes a γ-tubulin-independent microtubule nucleation centre through phase separation eLife. 2022 Jun; 11: e77362. doi: 10.7554/elife.77365 PMID: 35762204
• Yoshihiro Saito, Tomoya Yamashita, Naofumi Yoshida, Takuo Emoto, Shintaro Takeda, Tokiko Tabata, Masakazu Shinohara, Shigenobu Kishino, Yuta Sugiyama, Nahoko Kitamura, Hiroyuki Yamamoto, Tomofumi Takaya, Jun Ogawa, Ken-ichi Hirata Structural differences in bacterial lipopolysaccharides determine atherosclerotic plaque progression by regulating the accumulation of neutrophils Atherosclerosis. 2022 Oct; 358: 1-11. doi: 10.1016/j.atherosclerosis.2022.08.009 PMID:36049289
• Inhibition of glutaminase 1-mediated glutaminolysis improves pathological cardiac remodeling. American journal of physiology 　 Sachiko Yoshikawa, Manabu Nagao, Ryuji Toh, Masakazu Shinohara, Takuya Iino, Yasuhiro Irino, Makoto Nishimori, Hidekazu Tanaka, Seimi Satomi-Kobayashi, Tatsuro Ishida, Ken-Ichi Hirata　Heart and circulatory physiology. 2022 May 1; 322(5): H749-H761. doi: 10.1152/ajpheart.00692.2021 PMID: 35275762
• Gut Microbiota Influence the Development of Abdominal Aortic Aneurysm by Suppressing Macrophage Accumulation in Mice.　Ryohei Shinohara, Hitomi Nakashima, Takuo Emoto, Tomoya Yamashita, Yoshihiro Saito, Naofumi Yoshida, Taishi Inoue, Katsuhiro Yamanaka, Kenji Okada, Ken-Ichi Hirata Hypertension (Dallas, Tex.: 1979). 2022 Dec; 79(12): 2821-2829. doi: 10.1161/HYPERTENSIONAHA.122.19422 PMID: 36252141

脳こころ　Brain and Mind

• Microglial subpopulations with distinct transcriptome signatures vary across brain regions in the resting mouse brain. 　Rei Mishima, Masayuki Taniguchi, Kazutoshi Matsushita, Bowen Tian, Tomoyuki Furuyashiki Journal of Pharmacological Sciences. 2023 Mar; 151(3): 142-147. doi: 10.1016/j.jphs.2022.12.010 PMID: 36828616 Epub 2022 Dec 29.
• The transcription factor Hhex regulates inflammation-related genes in microglia.　 Risa Sakate; Masahiro Nishiyama; Yu Fukuda; Shiho Kitaoka; Tomoyuki Furuyashiki　 J Pharmacol Sci. 2022 Jul; 149(3): -. doi: 10.1016/j.jphs.2022.04.006 PMID: 35641029
• The 14-3-3γ isoform binds to and regulates the localization of endoplasmic reticulum (ER) membrane protein TMCC3 for the reticular network of the ER. 　Suhda S, Yamamoto Y, Wisesa S, Sada R, Sakisaka T　 Journal of Biological Chemistry. 2023 Feb; 299(2): -. doi: 10.1016/j.jbc.2022.102813 PMID: 36549645
• Circulating plasmablasts and follicular helper T-cell subsets are associated with antibody-positive autoimmune epilepsy. 　Atsushi Hara, Norio Chihara, Ritsu Akatani, Ryusei Nishigori, Asato Tsuji, Hajime Yoshimura, Michi Kawamoto, Yoshihisa Otsuka, Yasufumi Kageyama, Takayuki Kondo, Frank Leypoldt, Klaus-Peter Wandinger, Riki Matsumoto 　Frontiers in Immunology. 2022 Dec 8; 13: 1048428. doi: 10.3389/fimmu.2022.1048428 PMID: 36569937
• Transcription Factor c-Maf Promotes Immunoregulation of Programmed Cell Death 1-Expressed CD8+ T Cells in Multiple Sclerosis 　Shusuke Koto, Norio Chihara, Ritsu Akatani, Hiroko Nakano, Atsushi Hara, Kenji Sekiguchi, Riki Matsumoto, Tatsushi Toda Neurology® Neuroimmunology & Neuroinflammation. 2022 Apr 5; 9(4): e1166. doi: 10.1212/NXI.0000000000001166 PMID: 35383094
• Distinct connectivity patterns in human medial parietal cortices: Evidence from standardized connectivity map using cortico-cortical evoked potential. 　Togo M, Matsumoto R, Usami K, Kobayashi K, Takeyama H, Nakae T, Shimotake A, Kikuchi T, Yoshida K, Matsuhashi M, Kunieda T, Miyamoto S, Takahashi R, Ikeda A.　 Neuroimage 2022 Nov; 263: 119639. doi: 10.1016/j.neuroimage.2022.119639. PMID: 36155245
• Virtual reality-based real-time imaging reveals abnormal cortical dynamics during behavioral transitions in a mouse model of autism. 　Nobuhiro Nakai, Masaaki Sato, Okito Yamashita, Yukiko Sekine, Xiaochen Fu, Junichi Nakai, Andrew Zalesky, Toru Takumi　Cell reports. 2023 Mar; 112258. doi: 10.1016/j.celrep.2023.112258 PMID: 36990094
• An old model with new insights: endogenous retroviruses drive the evolvement toward ASD susceptibility and hijack transcription machinery during development 　Chia-Wen Lin, Jacob Ellegood, Kota Tamada, Ikuo Miura, Mikiko Konda, Kozue Takeshita, Koji Atarashi, Jason P Lerch, Shigeharu Wakana, Thomas J McHugh, Toru Takumi　 Molecular psychiatry. 2023 Mar 7. doi: 10.1038/s41380-023-01999-z PMID: 36882500
• A common epigenetic mechanism across different cellular origins underlies systemic immune dysregulation in an idiopathic autism mouse model. 　Chia-Wen Lin, Dian E Septyaningtrias, Hsu-Wen Chao, Mikiko Konda, Koji Atarashi, Kozue Takeshita, Kota Tamada, Jun Nomura, Yohei Sasagawa, Kaori Tanaka, Itoshi Nikaido, Kenya Honda, Thomas J McHugh, Toru Takumi 　Molecular psychiatry. 2022 Aug; 27(8): 3343-3354. doi: 10.1038/s41380-022-01566-y PMID: 35491410
• Dispensable role of Rac1 and Rac3 after cochlear hair cell specification 　Takashi Nakamura, Hirofumi Sakaguchi, Hiroaki Mohri, Yuzuru Ninoyu, Akihiro Goto, Taro Yamaguchi, Yoshitaka Hishikawa, Michiyuki Matsuda, Naoaki Saito, Takehiko Ueyama 　Journal of Molecular Medicine. 2023 Jul; 101(7): 843-854. doi: 10.1007/s00109-023-02317-4 PMID: 37204479
• S-Palmitoylation of Tyrosinase at Cysteine500 Regulates Melanogenesis. 　Yoko Niki, Naoko Adachi, Masaki Fukata, Yuko Fukata, Shinichiro Oku, Chieko Makino-Okamura, Seiji Takeuchi, Kazumasa Wakamatsu, Shosuke Ito, Lieve Declercq, Daniel B Yarosh, Tomas Mammone, Chikako Nishigori, Naoaki Saito, Takehiko Ueyama 　The Journal of investigative dermatology. 2023 Feb; 143(2): 317-327. doi: 10.1016/j.jid.2022.08.040 PMID: 36063887
• Late-onset hearing loss case associated with a heterozygous truncating variant of DIAPH1. 　Bong Jik Kim, Takushi Miyoshi, Taimur Chaudhry, Thomas B Friedman, Byung Yoon Choi, Takehiko Ueyama 　Clinical genetics. 2022 Apr; 101(4): 466-471. doi: 10.1111/cge.14115 PMID: 35060117
• Association between locomotive syndrome and anemia among community-dwelling older adults 　Haruhi Encho, Kazuaki Uchida, Junya Nakamura, Sachiko Mizuta, Toshihiro Akisue, Hisatomo Kowa, Rei Ono 　Geriatrics & gerontology international. 2023 Jun; 23(6): 426-429. doi: 10.1111/ggi.14593 PMID: 37165517
• The Japan-Multimodal Intervention Trial for Prevention of Dementia PRIME Tamba (J-MINT PRIME Tamba): Study protocol of a randomised controlled multi-domain intervention trial 　Ryoko Kumagai, Tohmi Osaki, Yutaro Oki, Shunsuke Murata, Kazuaki Uchida, Haruhi Encho, Rei Ono, Hisatomo Kowa　 Archives of Gerontology and Geriatrics. 2023 Jan; 104: 104803. doi: 10.1016/j.archger.2022.104803 PMID:36088747
• Self Assessment Memory Scale (SAMS), a new simple method for evaluating memory function 　Hisatomo Kowa, Maki Uchimura, Asuka Ohashi, Mamoru Hiroe, Rei Ono 　Frontiers in aging neuroscience. 2022 Nov 22; 14: 1024497-1024497. doi: 10.3389/fnagi.2022.1024497 PMID: 36483113

感染症　Infectious Disease

• Two sporadic cases of childhood-onset Hailey-Hailey disease with superimposed mosaicism. 　Yasuhiko Asahina, Umi Tahara, Satomi Aoki, Kazuhiko Nakabayashi, Chiharu Tateishi, Daisuke Hayashi, Masayuki Amagai, Daisuke Tsuruta, Akiharu Kubo　European journal of human genetics. 2023 Jun; 31(6): 716-720. doi: 10.1038/s41431-023-01316-w PMID: 36922631 Epub 2023 Mar 15
• Neurofibromatosis type 2 with mild Pierre-Robin sequence showing a heterozygous chromosome 22q12 microdeletion encompassing NF2 and MN1. 　Sonoko Saito, Noriko Ono, Takashi Sasaki, Satomi Aoki, Kenjiro Kosaki, Bunya Kuze, Kazuhiko Nakabayashi, Masayuki Amagai, Akiharu Kubo　Journal of human genetics. 2022 Nov; 67(11): 675-678. doi: 10.1038/s10038-022-01068-3 PMID: 35970985
• Autoimmune progesterone dermatitis treated with dienogest: A case report. 　Ai Yoshioka, Makoto Kunisada, Hitoshi Fukuda, Akiharu Kubo　 The Journal of dermatology. 2022 Oct; 49(10): e391-2392. doi: 10.1111/1346-8138.16445 PMID: 35587696
• ATF1 Restricts Human Herpesvirus 6A Replication via Beta Interferon Induction. 　Salma Aktar, Jun Arii, Thi Thu Huong Nguyen, Jing Rin Huang, Mitsuhiro Nishimura, Yasuko Mori 　Journal of virology. 2022 Oct 12; 96(19): e0126422. doi: 10.1128/jvi.01264-22 PMID: 36154610
• Cross-neutralizing activity against Omicron could be obtained in SARS-CoV-2 convalescent patients who received two doses of mRNA vaccination. 　Yukiya Kurahashi, Koichi Furukawa, Silvia Sutandhio, Lidya Handayani Tjan, Sachiyo Iwata, Shigeru Sano, Yoshiki Tohma, Hiroyuki Ohkita, Sachiko Nakamura, Mitsuhiro Nishimura, Jun Arii, Tatsunori Kiriu, Masatsugu Yamamoto, Tatsuya Nagano, Yoshihiro Nishimura, Yasuko Mori　The Journal of infectious diseases. 2022 Oct 17; 226(8): 1391-1395. doi: 10.1093/infdis/jiac178 PMID: 35512332
• Assessment of Neutralizing Antibody Response Against SARS-CoV-2 Variants After 2 to 3 Doses of the BNT162b2 mRNA COVID-19 Vaccine. 　Koichi Furukawa, Lidya Handayani Tjan, Yukiya Kurahashi, Silvia Sutandhio, Mitsuhiro Nishimura, Jun Arii, Yasuko Mori　 JAMA network open. 2022 May; 5(5): e2210780. doi: 10.1001/jamanetworkopen.2022.10780 PMID: 35532938
• Complete genome analyses of G12P [8] rotavirus strains from hospitalized children in Surabaya, Indonesia, 2017-2018. 　Laura Navika Yamani, Takako Utsumi, Yen Hai Doan, Yoshiki Fujii, Zayyin Dinana, Rury Mega Wahyuni, Emily Gunawan, Soegeng Soegijanto, Alpha Fardah Athiyyah, Subijanto Marto Sudarmo, Reza Gunadi Ranuh, Andy Darma, Soetjipto, Juniastuti, Rheza Gandi Bawono, Chieko Matsui, Lin Deng, Takayuki Abe, Hiroyuki Shimizu, Koji Ishii, Kazuhiko Katayama, Maria Inge Lusida, Ikuo Shoji　Journal of medical virology. 2023 Jan 10. doi: 10.1002/jmv.28485
• Hepatitis C virus NS5A protein promotes the lysosomal degradation of diacylglycerol O-acyltransferase 1 (DGAT1) via endosomal microautophagy. 　Putu Yuliandari, Chieko Matsui, Lin Deng, Takayuki Abe, Hiroyuki Mori, Shuhei Taguwa, Chikako Ono, Takasuke Fukuhara, Yoshiharu Matsuura, Ikuo Shoji　Autophagy Reports. 2022 Jul; 1(1): 264-285. doi: 10.1080/27694127.2022.2095591
• Impact after the Change from Voluntary to Universal Oral Rotavirus Vaccination on Consecutive Emergency Department Visits for Acute Gastroenteritis among Children in Kobe City, Japan (2016-2022). 　Hiroshi Yamaguchi, Kandai Nozu, Hiroaki Hanafusa, Yoshinori Nambu, Takumi Kido, Atsushi Kondo, Akihiro Tamura, Hiroyuki Awano, Ichiro Morioka, Hiroaki Nagase, Akihito Ishida　Vaccines. 2022 Oct; 10(11):1831. doi: 10.3390/vaccines10111831 PMID: 36366340
• Detecting MUC1 Variants in Patients Clinicopathologically Diagnosed With Having Autosomal Dominant Tubulointerstitial Kidney Disease. 　Eri Okada, Naoya Morisada, Tomoko Horinouchi, Hideki Fujii, Takayuki Tsuji, Masayoshi Miura, Hideyuki Katori, Masashi Kitagawa, Kunio Morozumi, Takanobu Toriyama, Yuki Nakamura, Ryuta Nishikomori, Sadayuki Nagai, Atsushi Kondo, Yuya Aoto, Shinya Ishiko, Rini Rossanti, Nana Sakakibara, China Nagano, Tomohiko Yamamura, Shingo Ishimori, Joichi Usui, Kunihiro Yamagata, Kazumoto Iijima, Toshiyuki Imasawa, Kandai Nozu 　Kidney international reports. 2022 Jan 4; 7(4): 857-866. doi: 10.1016/j.ekir.2021.12.037 PMID: 35497811 eCollection 2022 Apr.
• Subtype distribution and drug resistance patterns among HIV-1 strains prevalent in Makassar, Indonesia. 　Siti Qamariyah Khairunisa, Ni Luh Ayu Megasari, Shuhei Ueda, Tomohiro Kotaki, Afif Nurul Hidayati, - Nasronudin, Masanori Kameoka 　AIDS research and human retroviruses. 2023 Mar; 39(3): 124-129. doi: 10.1089/AID.2022.0139 PMID: 36656663
• Japanese Encephalitis DNA Vaccines with Epitope Modification Reduce the Induction of Cross-Reactive Antibodies against Dengue Virus and Antibody-Dependent Enhancement of Dengue Virus Infection. 　Tomohiro Kotaki, Yurie Nagai, Atsushi Yamanaka, Eiji Konishi, Masanori Kameoka　 Vaccines. 2022 Aug; 10(9): 1411. doi: 10.3390/vaccines10091411 PMID: 36146489
• Inactivation of SARS-CoV-2 and influenza A virus by dry fogging hypochlorous acid solution and hydrogen peroxide solution. 　Masahiro Urushidani, Akira Kawayoshi, Tomohiro Kotaki, Keiichi Saeki, Yasuko Mori, Masanori Kameoka 　PloS one. 2022 Apr 7; 17(4): e0261802. doi: 10.1371/journal.pone.0261802 PMID: 35389997

再生医学　Regenerative Medicine

• Paracrine effect of the stromal vascular fraction containing M2 macrophages on human chondrocytes through the Smad2/3 signaling pathway.　Masahiro Fujita, Tomoyuki Matsumoto, Shinya Hayashi, Shingo Hashimoto, Naoki Nakano, Toshihisa Maeda, Yuichi Kuroda, Yoshinori Takashima, Kenichi Kikuchi, Kensuke Anjiki, Kemmei Ikuta, Yuma Onoi, Shotaro Tachibana, Takehiko Matsushita, Hideki Iwaguro, Satoshi Sobajima, Takafumi Hiranaka, Ryosuke Kuroda 　Journal of cellular physiology. 2022 Sept; 237(9): 3627-3639. doi: 10.1002/jcp.30823 PMID: 35766589
• Biochemical Markers of Aging (Advanced Glycation End Products) and Degeneration Are Increased in Type 3 Rotator Cuff Tendon Stumps With Increased Signal Intensity Changes on MRI. 　Issei Shinohara, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Kohei Yamaura, Shintaro Mukohara, Tomoya Yoshikawa, Tatsuo Kato, Takahiro Furukawa, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda 　The American journal of sports medicine. 2022 Jun; 50(7): 1960-1970. doi: 10.1177/03635465221090649 PMID: 35486520
• Re-generation of cytotoxic γδT cells with distinctive signatures from human γδT-derived iPSCs. 　Nobuyuki Murai, Michiyo Koyanagi-Aoi, Hiroto Terashi, Takashi Aoi　 Stem Cell Reports. 2023 Apr 11; 28(4): 853-868. doi: 10.1016/j.stemcr.2023.02.010 PMID: 36963392
• A single RET mutation in Hirschsprung disease induces intestinal aganglionosis via a dominant-negative mechanism. 　Mukhamad Sunardi, Keisuke Ito, Yuya Sato, Toshihiro Uesaka, Mitsuhiro Iwasaki, Hideki Enomoto　 Cellular and Molecular Gastroenterology and Hepatology. 2023: 15(6): 1505-1524. doi: 10.1016/j.jcmgh.2022.12.003 PMID: 36521661 Epub 2022 Dec 13.

創薬・医療機器　New Drug & Medical Device Development

• Physiologically-based pharmacokinetic model to investigate the effect of pregnancy on risperidone and paliperidone pharmacokinetics: Application to a pregnant woman and her neonate. 　Walaa Y B Mahdy, Kazuhiro Yamamoto, Takahiro Ito, Naoko Fujiwara, Kazumichi Fujioka, Tadasu Horai, Ikuo Otsuka, Hitomi Imafuku, Tomohiro Omura, Kazumoto Iijima, Ikuko Yano Clinical and translational science. 2023 Apr; 16(4): 618-630. doi: 10.1111/cts.13473 PMID: 36655374 Epub 2023 Jan 19
• Effectiveness of pharmacist intervention for deprescribing potentially inappropriate medications: a prospective observational study. 　Takeshi Kimura, Misa Fujita, Michiko Shimizu, Kasumi Sumiyoshi, Saho Bansho, Kazuhiro Yamamoto, Tomohiro Omura, Ikuko Yano　 Journal of Pharmaceutical Health Care and Sciences. 2022 Apr; 8(1): 12. doi: 10.1186/s40780-022-00243-0 PMID: 35382881
• Population pharmacokinetics of everolimus in adult liver transplant patients: Comparison to tacrolimus disposition and extrapolation to pediatrics. 　Kotaro Itohara, Ikuko Yano, Shunsaku Nakagawa, Mitsuhiro Sugimoto, Machiko Hirai, Atsushi Yonezawa, Satoshi Imai, Takayuki Nakagawa, Daiki Hira, Takashi Ito, Koichiro Hata, Etsuro Hatano, Tomohiro Terada, Kazuo Matsubara. 　 Clinical and Translational Science. 2022 Nov; 15(11): 2652-2662. doi: 10.1111/cts.13389 PMID: 36004935
• Use of a short cartridge stapler is beneficial in pancreatic transection at the neck during laparoscopic distal pancreatectomy. 　Jun Ishida, Hirochika Toyama, Sadaki Asari, Tadahiro Goto, Yoshihide Nanno, Takuya Mizumoto, Daisuke Tsugawa, Shohei Komatsu, Kaori Kuramitsu, Hiroaki Yanagimoto, Masahiro Kido, Takumi Fukumoto 　Surgery today. 2023 Jan; 53(1): 153-157. doi: 10.1007/s00595-022-02540-5 PMID: 35879473
• Space-making particle therapy for unresectable hilar cholangiocarcinoma.　 Yu Hashimoto, Shohei Komatsu, Kazuki Terashima, Daisuke Tsugawa, Hiroaki Yanagimoto, Masaki Suga, Yusuke Demizu, Sunao Tokumaru, Tomoaki Okimoto, Ryohei Sasaki, Tetsuo Ajiki, Takumi Fukumoto 　Digestive surgery. 2022; 39(2-3): 99-108. doi: 10.1159/000524582 PMID: 35462363
• Tracking the Structural Development of Amyloid Precursors in the Insulin B Chain and the Inhibition Effect by Fibrinogen. 　Yamamoto N, Inoue R, Makino Y, Sekiguchi H, Shibayama N, Naito A, Sugiyama M, Chatani E.　 J. Phys. Chem. B. 2022 Dec 29; 126(51): 10797-10812. doi: 10.1021/acs.jpcb.2c05136. PMID:36534755
• Reactive oxygen species-inducing titanium peroxide nanoparticles as promising radiosensitizers for eliminating pancreatic cancer stem cells. 　Mohammed Salah, Hiroaki Akasaka, Yasuyuki Shimizu, Kenta Morita, Yuya Nishimura, Hikaru Kubota, Hiroki Kawaguchi, Tomomi Sogawa, Naritoshi Mukumoto, Chiaki Ogino, Ryohei Sasaki 　JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 2022 Apr 15; 41(1): 146. doi: 10.1186/s13046-022-02358-6 PMID: 35428310
• A Third Dose COVID-19 Vaccination in Allogeneic Hematopoietic Stem Cell Transplantation Patients. 　Marika Watanabe, Kimikazu Yakushijin, Yohei Funakoshi, Goh Ohji, Hiroya Ichikawa, Hironori Sakai, Wataru Hojo, Miki Saeki, Yuri Hirakawa, Sakuya Matsumoto, Rina Sakai, Shigeki Nagao, Akihito Kitao, Yoshiharu Miyata, Taiji Koyama, Yasuyuki Saito, Shinichiro Kawamoto, Katsuya Yamamoto, Mitsuhiro Ito, Tohru Murayama, Hiroshi Matsuoka, Hironobu Minami 　Vaccines. 2022 Oct 29; 10(11): 1830. doi: 10.3390/vaccines10111830 PMID: 36366338
• Safety and efficacy of nivolumab plus bevacizumab, paclitaxel for HER2-negative metastatic breast cancer: Primary results and biomarker data from a phase 2 trial (WJOG9917B). 　Yukinori Ozaki, Junji Tsurutani, Toru Mukohara, Tsutomu Iwasa, Masato Takahashi, Yuko Tanabe, Hidetaka Kawabata, Norikazu Masuda, Manabu Futamura, Hironobu Minami, Koji Matsumoto, Kenichi Yoshimura, Shigehisa Kitano, Toshimi Takano　 European journal of cancer (Oxford, England: 1990). 2022 Aug; 171: 193-202. doi: 10.1016/j.ejca.2022.05.014 PMID: 35728379
• Apixaban in Japanese patients with cancer-associated venous thromboembolism: a multi-center phase II trial. 　Yoshinori Imamura, Kazunori Otsui, Kenta Mori, Koichi Kitagawa, Hideaki Okada, Akito Hata, Hidetoshi Hayashi, Taku Nose, Shinya Ohata, Yoshiharu Miyata, Yohei Funakoshi, Masanori Toyoda, Kimikazu Yakushijin, Naomi Kiyota, Hiroshi Matsuoka, Hironobu Minami 　International journal of hematology. 2022 Apr; 115(4): 499-507. doi: 10.1007/s12185-022-03289-w PMID: 35079961

感覚器プラットフォーム　Sensory Systems

• The Japan Glaucoma Society guidelines for glaucoma 5th edition. 　Yoshiaki Kiuchi, Toshihiro Inoue, Nobuyuki Shoji, Makoto Nakamura, Masaki Tanito　 Japanese journal of ophthalmology. 2023 Mar; 67(2): 189-254. doi: 10.1007/s10384-022-00970-9 PMID: 36780040
• INTRAOPERATIVE OPTICAL COHERENCE TOMOGRAPHY FOR REAL-TIME VISUALIZATION OF THE POSITIONAL RELATIONSHIP BETWEEN BUCKLING MATERIAL AND RETINAL BREAKS DURING SCLERAL BUCKLING FOR RHEGMATOGENOUS RETINAL DETACHMENT. 　Yasuyuki Sotani, Hisanori Imai, Yukako Iwane, Tomohiro Yokogawa, Hiroko Yamada, Wataru Matsumiya, Akiko Miki, Sentaro Kusuhara, Makoto Nakamura 　Retina (Philadelphia, Pa.). 2022 Dec 1; 42(12): 2395-2400. doi: 10.1097/IAE.0000000000003610 PMID: 36394893

難治性がん×再生医学

• CDX2-induced intestinal metaplasia in human gastric organoids derived from induced pluripotent stem cells. 　Takahiro Koide, Michiyo Koyanagi-Aoi, Keiichiro Uehara, Yoshihiro Kakeji, Takashi Aoi iScience. 2022 Apr 28; 25(5): 104314. doi: 10.1016/j.isci.2022.104314 PMID: 35602937

難治性がん×創薬・医療機器

• N-(3,4-dimethoxyphenethyl)-6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-amine inhibits bladder cancer progression by suppressing YAP1/TAZ. 　Yusuke Shiraishi, Tomohiko Maehama, Miki Nishio, Junji Otani, Hiroki Hikasa, Tak Wah Mak, Takehiko Sasaki, Teruki Honma, Yasumitsu Kondoh, Hiroyuki Osada, Minoru Yoshida, Masato Fujisawa, Akira Suzuki 　GENES TO CELLS. 2022 Oct; 27(10): 602-612. doi: 10.1111/gtc.12979 PMID: 36054428
• The TIGD5 gene located in 8q24 and frequently amplified in ovarian cancers is a tumor suppressor. 　Yuntao Dai, Tetsuya Kawaguchi, Miki Nishio, Junji Otani, Hironori Tashiro, Yoshito Terai, Ryohei Sasaki, Tomohiko Maehama, Akira Suzuki 　GENES TO CELLS. 2022 Nov; 27(11):633-642. doi: 10.1111/gtc.12980 PMID: 36054307
• Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers. 　Hirotoshi Soyama, Miki Nishio, Junji Otani, Toshiko Sakuma, Shintaro Takao, Shigeo Hara, Takaaki Masuda, Koshi Mimori, Shinya Toyokuni, John P. Lydon, Kazuwa Nakao, Hiroshi Nishina, Takumi Fukumoto, Tomohiko Maehama, Akira Suzuki　 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022 Jul 19; 119(29): e2123134119. doi: 10.1073/pnas.2123134119 PMID: 35858357

代謝×脳こころ

• Chronic social defeat stress increases the amounts of 12-lipoxygenase lipid metabolites in the nucleus accumbens of stress-resilient mice. 　Satoshi Akiyama, Hirotaka Nagai, Shota Oike, Io Horikawa, Masakazu Shinohara, Yabin Lu, Takashi Futamura, Ryota Shinohara, Shiho Kitaoka, Tomoyuki Furuyashiki　Scientific Reports. 2022 Jul; 12(1): 11385. doi: 10.1038/s41598-022-15461-7 PMID: 35790870
• Single-Cell RNA Sequencing Reveals a Distinct Immune Landscape of Myeloid Cells in Coronary Culprit Plaques Causing Acute Coronary Syndrome. 　Takuo Emoto, Hiroyuki Yamamoto, Tomoya Yamashita, Tomofumi Takaya, Takahiro Sawada, Shintaro Takeda, Masayuki Taniguchi, Naoto Sasaki, Naofumi Yoshida, Yoshihiro Saito, Tharini Sivasubramaniyam, Hiromasa Otake, Tomoyuki Furuyashiki, Clinton S Robbins, Hiroya Kawai, Ken-Ichi Hirata　Circulation. 2022 May 3; 145(18): 1434-1436. doi: 10.1161/CIRCULATIONAHA.121.058414 PMID: 35500048

代謝×感染症

• LAT1 expression influences Paneth cell number and tumor development in Apc^Min/+ mice. 　Yunlong Sui, Namiko Hoshi, Ryuichi Ohgaki, Lingling Kong, Ryutaro Yoshida, Norihiro Okamoto, Masato Kinoshita, Haruka Miyazaki, Yuna Ku, Eri Tokunaga, Yuki Ito, Daisuke Watanabe, Makoto Ooi, Masakazu Shinohara, Kengo Sasaki, Yoh Zen, Takenori Kotani, Takashi Matozaki, Zibin Tian, Yoshikatsu Kanai, Yuzo Kodama 　Journal of Gastroenterology. 2023 May; 58(5): 444 - 457. doi: 10.1007/s00535-023-01960-5 PMID: 36739585 Epub 2023 Feb 5.

代謝×再生医学

• A Piezo1/KLF15/IL-6 axis mediates immobilization-induced muscle atrophy.　Yu Hirata, Kazuhiro Nomura, Daisuke Kato, Yoshihisa Tachibana, Takahiro Niikura, Kana Uchiyama, Tetsuya Hosooka, Tomoaki Fukui, Keisuke Oe, Ryosuke Kuroda, Yuji Hara, Takahiro Adachi, Koji Shibasaki, Hiroaki Wake, Wataru Ogawa　 The Journal of clinical investigation. 2022 May 16; 132(10): 1-13. doi: 10.1172/JCI154611 PMID: 35290243

感染症×創薬・医療機器

• Promising Efficacy of a Third Dose of mRNA SARS-CoV-2 Vaccination in Patients Treated with Anti-CD20 Antibody Who Failed 2-Dose Vaccination. 　Yohei Funakoshi, Kimikazu Yakushijin, Goh Ohji, Wataru Hojo, Hironori Sakai, Marika Watanabe, Akihito Kitao, Yoshiharu Miyata, Yasuyuki Saito, Shinichiro Kawamoto, Katsuya Yamamoto, Mitsuhiro Ito, Taiji Koyama, Yoshinori Imamura, Naomi Kiyota, Hiroshi Matsuoka, Yasuko Mori, Hironobu Minami　Vaccines. 2022 Jun 17; 10(6): 965. doi: 10.3390/vaccines10060965 PMID: 35746573
• Integrated analysis of tertiary lymphoid structures in relation to tumor-infiltrating lymphocytes and patient survival in pancreatic ductal adenocarcinoma. 　Takeshi Tanaka, Atsuhiro Masuda, Jun Inoue, Tsuyoshi Hamada, Takuya Ikegawa, Hirochika Toyama, Keitaro Sofue, Hideyuki Shiomi, Arata Sakai, Takashi Kobayashi, Shunta Tanaka, Ryota Nakano, Yasutaka Yamada, Shigeto Ashina, Masahiro Tsujimae, Kohei Yamakawa, Shohei Abe, Masanori Gonda, Shigeto Masuda, Noriko Inomata, Hisahiro Uemura, Shinya Kohashi, Kae Nagao, Maki Kanzawa, Tomoo Itoh, Yoshihide Ueda, Takumi Fukumoto, Yuzo Kodama　Journal of gastroenterology. 2023 Jan; 58(3): 277-291. doi: 10.1007/s00535-022-01939-8 PMID: 36705749

再生医学×創薬・医療機器

• Clinical Outcome of Patients with Pelvic and Retroperitoneal Bone and Soft Tissue Sarcoma: A Retrospective Multicenter Study in Japan. 　Toshiyuki Takemori, Teruya Kawamoto, Hitomi Hara, Naomasa Fukase, Shuichi Fujiwara, Ikuo Fujita, Takuya Fujimoto, Masayuki Morishita, Kazumichi Kitayama, Shunsuke Yahiro, Tomohiro Miyamoto, Masanori Saito, Jun Sugaya, Katsuhiro Hayashi, Hiroyuki Kawashima, Tomoaki Torigoe, Tomoki Nakamura, Hiroya Kondo, Toru Wakamatsu, Munenori Watanuki, Munehisa Kito, Satoshi Tsukushi, Akihito Nagano, Hidetatsu Outani, Shunichi Toki, Shunji Nishimura, Hiroshi Kobayashi, Itsuo Watanabe, Yusuke Demizu, Ryohei Sasaki, Takumi Fukumoto, Takahiro Niikura, Ryosuke Kuroda, Toshihiro Akisue　Cancers. 2022 Jun 20; 14(12): 3023. doi: 10.3390/cancers14123023 PMID: 35740688
• Uts2b is a microbiota-regulated gene expressed in vagal afferent neurons connected to enteroendocrine cells producing cholecystokinin. 　Yuta Yoshioka, Yoshihisa Tachibana, Toshihiro Uesaka, Hiroyuki Hioki, Yuya Sato, Takumi Fukumoto, Hideki Enomoto　Biochemical and biophysical research communications. 2022 Jun 11; 608: 66-72. doi: 10.1016/j.bbrc.2022.03.117 PMID: 35390674

感染症×再生医学×創薬・医療機器

• Increased expression of SPRR1A is associated with a poor prognosis in pancreatic ductal adenocarcinoma. 　Kohei Yamakawa, Michiyo Koyanagi-Aoi, Keiichiro Uehara, Atsuhiro Masuda, Hiroaki Yanagimoto, Hirochika Toyama, Takumi Fukumoto, Yuzo Kodama, Takashi Aoi　PLOS ONE. 2022 May 26; 17(5): e0266620. doi: 10.1371/journal.pone.0266620 PMID: 35617311