CMX Young Scientists Collaborative Research Keynote Lecture
Radial glia: the basis for mammalian neurogenesis
| (DATE) 15:50 ～17:30, June 22, 2023 |
| (VENUE) ・Face-to-Face: Shinryoku Memorial Hall B (Shinryoku Kaikan Kinen Hall B ) ・Online: Attendees will be notified later. |
| Our bodies start as a single cell, the fertilized egg. Cells divide rapidly, producing an enormous number of different types of cells. About four weeks after fertilization, a structure called the "neural tube" appears and is compartmentalized, with the anterior end region forming the basis of the "brain. The "neural stem cells" in the neural tube, called "radial glia," give rise to neurons (neurogenesis) and support their migration. As development progresses, the length of neural stem cells increases, requiring appropriate "molecules" to be placed in the right places within the cell. I was analyzing the function of the molecule Pax6, a critical factor in neural tube compartmentalization and neurogenesis, when a graduate student noticed that mRNAs for a molecule called cyclin D2, which regulates the cell division cycle, gather onto the tip of neural stem cells, which sparked my interest in the mechanism of mRNA transport in radial glia. In my talk, I will discuss the latest results of our research and show how interesting it is to test hypotheses in a study. |