2025
- Tanaka A, Abe M, Namisaki T, Shimoda S, Zeniya M, Ido A, Yoshiji H, Ohira H, Harada K, Kakuda Y, Umeda A, Kamiya Y, Higashine Y, Hojo S, Imai T, Kawano T, Nakanuma Y, Tsubouchi H.
A placebo-controlled Phase 2 trial of E6011, anti-human fractalkine monoclonal antibody, in primary biliary cholangitis.
J Transl Autoimmun. 2025 Mar;20(10):100283.
2024
- Eng JW, Kato Y, Adachi Y, Swaminathan B, Naiche LA, Vadakath R, Sakamoto Y, Nakazawa Y, Tachino S, Ito K, Abe T, Minoshima Y, Hoshino-Negishi K, Ogasawara H, Kawakatsu T, Nishimura M, Katayama M, Shimizu M, Tahara K, Sato T, Suzuki K, Agarwala K, Iwata M, Nomoto K, Ozawa Y, Imai T, Funahashi Y, Matsui J, Kitajewski J.
Inhibition of Notch4 Using Novel Neutralizing Antibodies Reduces Tumor Growth in Murine Cancer Models by Targeting the Tumor Endothelium.
Cancer Res Commun. 2024 Jul;4(7):1881-1893. - Hasegawa T, Utsunomiya A, Chino T, Kasamatsu H, Shimizu T, Matsushita T, Obara T, Ishii N, Ogasawara H, Ikeda W, Imai T, Oyama N, Hasegawa M.
Anti-CX3CL1 (fractalkine) monoclonal antibody attenuates lung and skin fibrosis in sclerodermatous graft-versus-host disease mouse model.
Arthritis Res Ther. 2024 May 3;26(1):94. - Abe S, Masuda A, Matsumoto T, Inoue J, Toyama H, Sakai A, Kobayashi T, Tanaka T, Tsujimae M, Yamakawa K, Gonda M, Masuda S, Uemura H, Kohashi S, Inomata N, Nagao K, Harada Y, Miki M, Irie Y, Juri N, Ko T, Yokotani Y, Oka Y, Ota S, Kanzawa M, Itoh T, Imai T, Fukumoto T, Hara E, Kodama Y.
Impact of intratumoral microbiome on tumor immunity and prognosis in human pancreatic ductal adenocarcinoma.
J Gastroenterol. 2024 Mar;59(3):250-262. - Tanaka Y, Takeuchi T, Yamanaka H, Nanki T, Umehara H, Yasuda N, Tago F, Kitahara Y, Kawakubo M, Torii K, Hojo S, Kawano T, Imai T.
Long-term safety and efficacy of E6011, an anti-fractalkine monoclonal antibody, in patients with rheumatoid arthritis inadequately responding to methotrexate.
Mod Rheumatol. 2024Jan;34(1):37-44. - Tanaka Y, Takeuchi T, Yamanaka H, Nanki T, Umehara H, Yasuda N, Tago F, Kitahara Y, Kawakubo M, Torii K, Hojo S, Kawano T, Imai T.
Long-term evaluation of E6011, an anti-fractalkine monoclonal antibody, in patients with rheumatoid arthritis inadequately responding to biological disease-modifying antirheumatic drugs.
Mod Rheumatol. 2024Jan;34(1):45-49.
2023
- Ashina S, Masuda A, Yamakawa K, Hamada T, Tsujimae M, Tanaka T, Toyama H, Sofue K, Shiomi H, Sakai A, Kobayashi T, Abe S, Gonda M, Masuda S, Inomata N, Uemura H, Kohashi S, Nagao K, Harada Y, Miki M, Juri N, Irie Y, Kanzawa M, Itoh T, Inoue J, Imai T, Fukumoto T, Kodama Y.
A comprehensive analysis of tumor-stromal collagen in relation to pathological, molecular, and immune characteristics and patient survival in pancreatic ductal adenocarcinoma.
J Gastroenterol. 2023 Oct;58(10):1055-1067. - Kuboi Y, Suzuki Y, Motoi S, Matsui C, Toritsuka N, Nakatani T, Tahara K, Takahashi Y, Ida Y, Tomimatsu A, Soejima M, Imai T.
Identification of potent siRNA targeting complement C5 and its robust activity in pre-clinical models of myasthenia gravis and collagen-induced arthritis.
Mol Ther Nucleic Acids. 2023 Jan 13;31:339-351. - Tsukamoto S, Sugi NH, Nishibata K, Nakazawa Y, Ito D, Fukushima S, Nakagawa T, Ichikawa K, Kato Y, Kakiuchi D, Goto A, Itoh-Yagi M, Aota T, Inoue S, Yamane Y, Murai N, Azuma H, Nagao S, Sasai K, Akagi T, Imai T, Matsui J, Matsushima T.
ER851, a novel selective inhibitor of AXL, overcomes resistance to antimitotic drugs.
Mol Cancer Ther. 2023 Jan 3;22(1):12-24.
2022
- Kuboi Y, Kuroda Y, Ohkuro M, Motoi S, Tomimori Y, Yasuda H, Yasuda N, Imai T, Matsuo K.
The Fractalkine-CX3CR1 Axis Regulates Non-inflammatory Osteoclastogenesis by Enhancing Precursor Cell Survival.
JBMR Plus. 2022 Sep 22;6(10):e10680.
2021
- Matsuoka K, Naganuma M, Hibi T, Tsubouchi H, Oketani K, Katsurabara T, Hojo S, Takenaka O, Kawano T, Imai T, Kanai T.
Phase 1 study on the safety and efficacy of E6011, antifractalkine antibody, in patients with Crohn's disease.
J Gastroenterol Hepatol. 2021 Aug;36(8):2180-86. - Tanaka Y, Takeuchi T, Yamanaka H, Nanki T, Umehara H, Yasuda N, Tago F, Kitahara Y, Kawakubo M, Torii K, Hojo S, Kawano T, Imai T.
A phase 2 study of E6011, an anti-Fractalkine monoclonal antibody, in patients with rheumatoid arthritis inadequately responding to biological disease-modifying antirheumatic drugs.
Mod Rheumatol. 2021 Jul;31(4):783-89. - Mizutani S, Nishio J, Kondo K, Motomura K, Yamada Z, Masuoka S, Yamada S, Muraoka S, Ishii N, Kuboi Y, Sendo S, Mikami T, Imai T, Nanki T.
Treatment with an Anti-CX3CL1 Antibody Suppresses M1 Macrophage Infiltration in Interstitial Lung Disease in SKG Mice.
Pharmaceuticals. 2021 May 17;14(5):474. - Tanaka Y, Takeuchi T, Yamanaka H, Nanki T, Umehara H, Yasuda N, Tago F, Kitahara Y, Kawakubo M, Torii K, Hojo S, Kawano T, Imai T.
Efficacy and Safety of E6011, an Anti-Fractalkine Monoclonal Antibody, in Patients With Active Rheumatoid Arthritis With Inadequate Response to Methotrexate: Results of a Randomized, Double-Blind, Placebo-Controlled Phase II Study.
Arthritis Rheumatol. 2021 Apr;73(4):587-95. - Motoi S, Uesugi M, Obara T, Moriya K, Arita Y, Ogasawara H, Soejima M, Imai T, Kawano T.
Serum APOA4 Pharmacodynamically Represents Administered Recombinant Human Hepatocyte Growth Factor (E3112).
2021 Int J Mol Sci. Apr 27;22(9):4578.
2020
- Watanabe T, Watanabe T, Kakuta J, Saito S, Hasehira K, Kiyoi K, Imai T, Tateno H.
Monoclonal antibodies specific for podocalyxin expressed on human induced pluripotent stem cells.
Biochem Biophys Res Commun. 2020 Nov 19;532(4):647-54. - Yamada S, Miyoshi S, Nishio J, Mizutani S, Yamada Z, Kusunoki N, Sato H, Kuboi Y, Hoshino-Negishi K, Ishii N, Imai T, Minami T, Nakano H, Kawai S, Nanki T.
Effects of CX3CL1 inhibition on murine bleomycin-induced interstitial pneumonia.
Eur J Inflammation. 2020 Sep 24;18:1-10.
2019
- Luong VH, Utsunomiya A, Chino T, Doanh LH, Matsushita T, Obara T, Kuboi Y, Ishii N, Machinaga A, Ogasawara H, Ikeda W, Kawano T, Imai T, Oyama N, Hasegawa M.
Inhibition of the Progression of Skin Inflammation, Fibrosis, and Vascular Injury by Blockade of the CX3CL1/CX3CR1 Pathway in Experimental Mouse Models of Systemic Sclerosis.
Arthritis Rheumatol. 2019 Nov;71(11):1923-1934. - Tabuchi H, Katsurabara T, Mori M, Aoyama M, Obara T, Yasuda N, Kawano T, Imai T, Ieiri I, Kumagai Y.
Pharmacokinetics, Pharmacodynamics, and Safety of E6011, a Novel Humanized Antifractalkine (CX3CL1) Monoclonal Antibody: A Randomized, Double-Blind, Placebo-Controlled Single-Ascending-Dose Study.
J Clin Pharmacol. 2019 May;59(5):688-701. - Kuboi Y, Nishimura M, Ikeda W, Nakatani T, Seki Y, Yamaura Y, Ogawa K, Hamaguchi A, Muramoto K, Mizuno K, Ogasawara H, Yamauchi T, Yasuda N, Onodera H, ＊Imai T.
Blockade of the Fractalkine-CX3CR1 Axis Ameliorates Experimental Colitis by Dislodging Venous Crawling Monocytes.
Int Immunol. 2019 Apr 26;31(5):287-302. - Motoi S, Toyoda H, Obara T, Ohta E, Arita Y, Negishi K, Moriya K, Kuboi Y, Soejima M, Imai T, Ido A, Tsubouchi H, Kawano T.
Anti-Apoptotic Effects of Recombinant Human Hepatocyte Growth Factor on Hepatocytes Were Associated with Intrahepatic Hemorrhage Suppression Indicated by the Preservation of Prothrombin Time.
2019 Int J Mol Sci. Apr 12;20(8):1821. - Hoshino-Negishi K, Ohkuro M, Nakatani T, Kuboi Y, Nishimura M, Ida Y, Kakuta J, Hamaguchi A, Kumai M, Kamisako T, Sugiyama F, Ikeda W, Ishii N, Yasuda N, ＊Imai T.
Role of Anti-Fractalkine Antibody in Suppression of Joint Destruction by Inhibiting Migration of Osteoclast Precursors to the Synovium in Experimental Arthritis.
Arthritis Rheumatol. 2019 Feb;71(2):222-31. - Morita N, Umemoto E, Fujita S, Hayashi A, Kikuta J, Kimura I, Haneda T, Imai T, Inoue A, Mimuro H, Maeda Y, Kayama H, Okumura R, Aoki J, Okada N, Kida T, Ishii M, Nabeshima R, Takeda K.
GPR31-dependent dendrite protrusion of intestinal CX3CR1+ cells by bacterial metabolites.
Nature. 2019 Feb;566(7742):110-14.
2018
- Tanaka Y, Takeuchi T, Umehara H, Nanki T, Yasuda N, Tago F, Kawakubo M, Kitahara Y, Hojo S, Kawano T, Imai T.
Safety, pharmacokinetics, and efficacy of E6011, an antifractalkine monoclonal antibody, in a first-in-patient phase 1/2 study on rheumatoid arthritis.
Mod Rheumatol. 2018 Jan;28(1):58-65.
2017
- Wakita H, Yanagawa T, Kuboi Y, Imai T.
E6130, a Novel CX3C Chemokine Receptor 1 (CX3CR1) Modulator, Attenuates Mucosal Inflammation and Reduces CX3CR1+ Leukocyte Trafficking in Mice with Colitis.
Mol Pharmacol. 2017 Nov;92(5):502-9. - Sato H, Muraoka S, Kusunoki N, Masuoka S, Yamada S, Ogasawara H, Imai T, Akasaka Y, Tochigi N, Takahashi H, Tsuchiya K, Kawai S, Nanki T.
Resistin upregulates chemokine production by fibroblast-like synoviocytes from patients with rheumatoid arthritis.
Arthritis 2017 Res Ther.19(1):263.
2016
- Kojima C, Fusaoka-Nishioka E, Imai T, Nakahira A, Onodera H.
Dendrigraft polylysine coated-poly (glycolic acid) fibrous scaffolds for hippocampal neurons.
J Biomed Mater Res A. 2016 Nov;104(11):2744-50.
2013
- Kitagawa Y, Kikuchi S, Arita Y, Nishimura M, Mizuno K, Ogasawara H, Kawano T, Ochiai T, Otsuji E, ＊Imai T.
Inhibition of CCL20 increases mortality in models of mouse sepsis with intestinal apoptosis.
Surgery. 2013 Jul;154(1):78-88. - Hoshino A, Ueha S, Hanada S, Imai T, Ito M, Yamamoto K, Matsushima K, Yamaguchi A, Iimura T.
Roles of chemokine receptor CX3CR1 in maintaining murine bone homeostasis through the regulation of both osteoblasts and osteoclasts.
J Cell Sci. 2013 Feb 15;126(Pt 4):1032-45.
2012
- Kitagawa M, Takebe A, Ono Y, Imai T, Nakao K, Nishikawa S, Era T.
Phf14, a novel regulator of mesenchyme growth via platelet-derived growth factor (PDGF) receptor-(alpha).
J Biol Chem. 2012 Aug 10;287(33):27983-96. - Suzuki F, Kubota T, Miyazaki Y, Ishikawa K, Ebisawa M, Hirohata S, Ogura T, Mizusawa H, Imai T, Miyasaka N, Nanki T.
Serum level of soluble CX3CL1/fractalkine is elevated in patients with polymyositis and dermatomyositis, which is correlated with disease activity.
Arthritis Res Ther. 2012 Mar 6;14(2):R48.
2011
- Fusaoka-Nishioka E, Shimono C, Taniguchi Y, Togawa A, Yamada A, Inoue E, Onodera H, Sekiguchi K, ＊Imai T.
Differential effects of laminin isoforms on axon and dendrite development in hippocampal neurons.
Neurosci Res. 2011 Dec;71(4):421-6. - Kiyozumi D, Osada A, Sugimoto N, Weber CN, Ono Y, Imai T, Okada A, Sekiguchi K.
Identification of genes expressed during hair follicle induction.
J Dermatol. 2011 Jul;38(7):674-9.
2010
- Tagi T, Matsui T, Kikuchi S, Hoshi S, Ochiai T, Kokuba Y, Kinoshita-Ida Y, Kisumi-Hayashi F, Morimoto K, Imai T, Imoto I, Inazawa J, Otsuji E.
Dermokine as a novel biomarker for early-stage colorectal cancer.
J Gastroenterol. 2010 Dec;45(12):1201-11. - Hoshino A, Iimura T, Ueha S, Hanada S, Maruoka Y, Mayahara M, Suzuki K, Imai T, Ito M, Manome Y, Yasuhara M, Kirino T, Yamaguchi A, Matsushima K, Yamamoto K.
Deficiency of chemokine receptor CCR1 causes osteopenia due to impaired functions of osteoclasts and osteoblasts.
J Biol Chem. 2010 Sep 10;285(37):28826-37.
2009
- Koizumi K, Saitoh Y, Minami T, Takeno N, Tsuneyama K, Miyahara T, Nakayama T, Sakurai H, Takano Y, Nishimura M, Imai T, Yoshie O, Saiki I.
Role of CX3CL1/fractalkine in osteoclast differentiation and bone resorption.
J Immunol. 2009 Dec 15;183(12):7825-31.
2008
- Holmes FE, Arnott N, Vanderplank P, Kerr NCH, Longbrake EE, Popovich PG, Imai T, Combadiere C, Murphy PM, Wynick D.
Intra-neural administration of fractalkine attenuates neuropathic pain-related behaviour.
J Neurochem. 2008 Jul;106(2):640-9. - Morimoto K, Satoh-Yamaguchi K, Hamaguchi A, Inoue Y, Takeuchi M, Okada M, Ikeda W, Takai Y, ＊Imai T.
Interaction of cancer cells with platelets mediated by Necl-5/poliovirus receptor enhances cancer cell metastasis to the lungs.
Oncogene. 2008 Jan 10;27(3):264-73.
2007
- Mizutani N, Sakurai T, Shibata T, Uchida K, Fujita J, Kawashima R, Kawamura YI, Toyama-Sorimachi N, Imai T, Dohi T.
Dose-dependent differential regulation of cytokine secretion from macrophages by fractalkine.
J Immunol. 2007 Dec 1;179(11):7478-87 - Ono Y, Nakatani T, Sakamoto Y, Mizuhara E, Minaki Y, Kumai M, Hamaguchi A, Nishimura M, Inoue Y, Hayashi H, Takahashi J, Imai T.
Differences in neurogenic potential in floor plate cells along an anteroposterior location: Midbrain dopaminergic neurons originate from mesencephalic floor plate cells.
Development. 2007 Sep;134(17):3213-25. - Kobayashi T, Okamoto S, Iwakami Y, Nakazawa A, Hisamatsu T, Chinen H, Kamada N, Imai T, Goto H, Hibi T.
Exclusive increase of CX3CR1(+)CD28(-)CD4(+) T cells in inflammatory bowel disease and their recruitment as intraepithelial lymphocytes.
Inflamm Bowel Dis. 2007 Jul;13(7):837-46. - Sugihara-Mizuno Y, Adachi M, Kobayashi Y, Hamazaki Y, Nishimura M, Imai T, Furuse M, Tsukita S.
Molecular characterization of angiomotin/JEAP family proteins: Interaction with MUPP1/Patj and their endogenous properties.
Genes Cells. 2007 Apr;12(4):473-86. - Ueha S, Murai M, Yoneyama H, Kitabatake M, Imai T, Shimaoka T, Yonehara S, Ishikawa S, Matsushima K.
Intervention of MAdCAM-1 or fractalkine alleviates graft-versus-host reaction associated intestinal injury while preserving graft-versus-tumor effects.
J Leukoc Biol. 2007 Jan;81(1):176-85.
2006
- Ishizaki H, Togawa A, Tanaka-Okamoto M, Hori K, Nishimura M, Hamaguchi A, Imai T, Takai Y, Miyoshi J.
Defective chemokine-directed lymphocyte migration and development in the absence of Rho guanosine diphosphate-dissociation inhibitors (alpha) and (beta).
J Immunol. 2006 Dec 15;177(12):8512-21. - Ohmori K, Fukui F, Kiso M, Imai T, Yoshie O, Hasegawa H, Matsushima K, Kannagi R.
Identification of cutaneous lymphocyte-associated antigen as sialyl 6-sulfo Lewis X, a selectin ligand expressed on a subset of skin-homing helper memory T cells.
Blood. 2006 Apr 15;107(8):3197-204.
2005
- Suzuki F, Nanki T, Imai T, Kikuchi H, Hirohata S, Kohsaka H, Miyasaka N.
Inhibition of CX3CL1 (fractalkine) improves experimental autoimmune myositis in SJL/J mice.
J Immunol. 2005 Nov 15;175(10):6987-96. - Minaki Y, Mizuhara E, Morimoto K, Nakatani T, Sakamoto Y, Inoue Y, Satoh K, Imai T, Takai Y, Ono Y.
Migrating postmitotic neural precursor cells in the ventricular zone extend apical processes and form adherens junctions near the ventricle in the developing spinal cord.
Neurosci Res. 2005 Jul;52(3):250-62. - Kiyozumi D, Osada A, Sugimoto N, Weber CN, Ono Y, Imai T, Okada A, Sekiguchi K.
Identification of a novel cell-adhesive protein spatiotemporally expressed in the basement membrane of mouse developing hair follicle.
Exp Cell Res. 2005 May 15;306(1):9-23. - Sawai H, Park YW, Roberson J, Imai T, Goronzy JJ, Weyand CM.
T cell costimulation by fractalkine-expressing synoviocytes in rheumatoid arthritis.
Arthritis Rheum. 2005 May;52(5):1392-401. - Inoue A, Hasegawa H, Kohno M, Ito MR, Terada M, Imai T, Yoshie O, Nose M, Fujita S.
Antagonist of fractalkine (CX3CL1) delays the initiation and ameliorates the progression of lupus nephritis in MRL/lpr mice.
Arthritis Rheum. 2005 May;52(5):1522-33. - Osada A, Kiyozumi D, Tsutsui K, Ono Y, Weber CN, Sugimoto N, Imai T, Okada A, Sekiguchi K.
Expression of MAEG, a novel basement membrane protein, in mouse hair follicle morphogenesis.
Exp Cell Res. 2005 Feb 1;303(1):148-59.
2004
- Nanki T, Urasaki Y, Imai T, Nishimura M, Muramoto K, Kubota T, Miyasaka N.
Inhibition of fractalkine ameliorates murine collagen-induced arthritis.
J Immunol. 2004 Dec 1;173(11):7010-6. - Kakunaga S, Ikeda W, Shingai T, Fujito T, Yamada A, Minami Y, Imai T, Takai Y.
Enhancement of serum- and platelet-derived growth factor-induced cell proliferation by Necl-5/Tage4/poliovirus receptor/CD155 through the Ras-Raf-MEK-ERK signaling.
J Biol Chem. 2004 Aug 27;279(35):36419-25. - Matsui T, Hayashi-Kisumi F, Kinoshita Y, Katahira S, Morita K, Miyachi Y, Ono Y, Imai T, Tanigawa Y, Komiya T, Tsukita S.
Identification of novel keratinocyte-secreted peptides dermokine-(alpha)/- (beta) and a new stratified epithelium-secreted protein gene complex on human chromosome 19q13.1.
Genomics. 2004 Aug;84(2):384-97. - Ooshio T, Irie K, Morimoto K, Fukuhara A, Imai T, Takai Y.
Involvement of LMO7 in the association of two cell-cell adhesion molecules, nectin and E-cadherin, through afadin and (alpha)-actinin in epithelial cells.
J Biol Chem. 2004 Jul 23;279(30):31365-73. - Ikeda W, Kakunaga S, Takekuni K, Shingai T, Satoh K, Morimoto K, Takeuchi M, Imai T, Takai Y.
Nectin-like Molecule-5/Tage4 Enhances Cell Migration in an Integrin-dependent, Nectin-3-independent Manner.
J Biol Chem. 2004 Apr 23;279(17):18015-25. - Yoshikawa M, Nakajima T, Matsumoto K, Okada N, Tsukidate T, Iida M, Otori N, Haruna SI, Moriyama H, Imai T, Saito H.
TNF-(alpha) and IL-4 regulate expression of fractalkine (CX(3)CL1) as a membrane-anchored proadhesive protein and soluble chemotactic peptide on human fibroblasts.
FEBS Lett. 2004 Mar 12;561(1-3):105-10. - Ohtani N, Ohtani H, Nakayama T, Naganuma H, Sato E, Imai T, Nagura H, Yoshie O.
Infiltration of CD8+ T cells containing RANTES/CCL5+ cytoplasmic granules in actively inflammatory lesions of human chronic gastritis.
Lab Invest. 2004 Mar;84(3):368-75.
2003
- Shingai T, Ikeda W, Kakunaga S, Morimoto K, Takekuni K, Itoh S, Satoh K, Takeuchi M, Imai T, Monden M, Takai Y.
Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells.
J Biol Chem. 2003 Sep 12;278(37):35421-7.d - Ikeda W, Kakunaga S, Itoh S, Shingai T, Takekuni K, Satoh K, Inoue Y, Hamaguchi A, Morimoto K, Takeuchi M, Imai T, Takai Y.
Tage4/nectin-like molecule-5 heterophilically trans-interacts with cell adhesion molecule nectin-3 and enhances cell migration.
J Biol Chem. 2003 Jul 25;278(30):28167-72. - Yoneda O, Imai T, Nishimura M, Miyaji M, Mimori T, Okazaki T, Domae N, Fujimoto H, Minami Y, Kono T, Bloom E.T, Umehara H.
Membrane-bound form of fractalkine induces IFN- production by NK cells.
Eur J Immunol. 2003 Jan;33(1):53-8.
2002
- Nanki T, Imai T, Nagasaka K, Urasaki Y, Nonomura Y, Taniguchi K, Hayashida K, Hasegawa J, Yoshie O, Miyasaka N.
Migration of CX3CR1-positive T cells producing type 1 cytokines and cytotoxic molecules into the synovium of patients with rheumatoid arthritis.
Arthritis Rheum. 2002 Nov;46(11):2878-83. - Nishimura M, Umehara H, Nakayama T, Yoneda O, Hieshima K, Kakizaki M, Dohmae N, Yoshie O, ＊Imai T.
Dual functions of fractalkine/CX3C ligand 1 in trafficking of perforin(+)/granzyme B(+) cytotoxic effector lymphocytes that are defined by Cx3CR1 expression.
J Immunol. 2002 Jun 15;168(12):6173-80. - Fong A.M, Alam S.M, Imai T, Haribabu B, Patel D.D.
CX3CR1 tyrosine sulfation enhances fractalkine-induced cell adhesion.
J Biol Chem. 2002 May 31;277(22):19418-23. - Nishimura M, Kakizaki M, Ono Y, Morimoto K, Takeuchi M, Inoue Y, ＊Imai T, ＊Takai Y.
JEAP, a novel component of tight junctions in exocrine cells.
J Biol Chem. 2002 Feb 15;277(7):5583-7.
2001
- Harrison J.K, Fong A.M, Swain P.A.W, Chen S, Yu Y-RA, Salafranca M.N, Greenleaf W.B, Imai T, Patel D.D.
Mutational analysis of the fractalkine chemokine domain. Basic amino acid residues differentially contribute to CX3CR1 binding, signaling, and cell adhesion.
J Biol Chem. 2001 Jun 15;276(24):21632-41. - Umehara H, Goda S, Imai T, Nagano Y, Minami Y, Tanaka Y, Okazaki T, Bloom E.T, Domae N.
Fractalkine, a CX3C-chemokine, functions predominantly as an adhesion molecule in monocytic cell line THP-1.
Immunol Cell Biol. 2001 Jun;79(3):298-302. - Patel D.D, Koopmann W, Imai T, Whichard L.P, Yoshie O, Krangel M.S.
Chemokines have diverse abilities to form solid phase gradients.
Clin Immunol. 2001 Apr;99(1):43-52. - Kawasaki S, Takizawa H, Yoneyama H, Nakayama T, Fujisawa R, Izumizaki M, Imai T, Yoshie O, Homma I, Yamamoto K, Matsushima K.
Intervention of thymus and activation-regulated chemokine attenuates the development of allergic airway inflammation and hyperresponsiveness in mice.
J Immunol. 2001 Feb 1;166(3):2055-62. - Hashida H, Takabayashi A, Adachi M, Imai T, Kondo K, Kohno N, Yamaoka Y, Miyake M.
The novel monoclonal antibody MH8-4 inhibiting cell motility recognizes integrin alpha 3: inverse of its expression with metastases in colon cancer.
Int J Oncol. 2001 Jan;18(1):89-95.
2000
- Yoneda O, Imai T, Goda S, Inoue H, Yamauchi A, Okazaki T, Imai H, Yoshie O, Bloom E.T, Domae N, Umehara H.
Fractalkine-mediated endothelial cell injury by NK cells.
J Immunol. 2000 Apr 15;164(8):4055-62. - Goda S, Imai T, Yoshie O, Yoneda O, Inoue H, Nagano Y, Okazaki T, Imai H, Bloom E.T, Domae N, Umehara H.
CX3C-chemokine, fractalkine-enhanced adhesion of THP-1 cells to endothelial cells through integrin-dependent and -independent mechanisms.
J Immunol. 2000 Apr 15;164(8):4313-20. - Fong A.M, Erickson H.P, Zachariah J.P, Poon S, Schamberg N.J, Imai T, Patel D.D.
Ultrastructure and function of the fractalkine mucin domain in CX(3)C chemokine domain presentation.
J Biol Chem. 2000 Feb 11;275(6):3781-6.
1999
- Nagira M, Sato A, Miki S, Imai T, Yoshie O.
Enhanced HIV-1 replication by chemokines constitutively expressed in secondary lymphoid tissues.
Virology. 1999 Nov 25;264(2):422-6. - Ishikawa-Mochizuki I, Kitaura M, Baba M, Nakayama T, Izawa D, Imai T, Yamada H, Hieshima K, Suzuki R, Nomiyama H, Yoshie O.
Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus.
FEBS Lett. 1999 Nov 5;460(3):544-8. - Vestergaard C, Yoneyama H, Murai M, Nakamura K, Tamaki K, Terashima Y, Imai T, Yoshie O, Irimura T, Mizutani H, Matsushima K.
Overproduction of Th2-specific chemokines in NC/Nga mice exhibiting atopic dermatitis-like lesions.
J Clin Invest. 1999 Oct;104(8):1097-105. - Kitaura M, Suzuki N, Imai T, Takagi S, Suzuki R, Nakajima T, Hirai K, Nomiyama H, Yoshie O.
Molecular Cloning of a Novel Human CC Chemokine (Eotaxin-3) That Is a Functional Ligand of CC Chemokine Receptor 3.
J Biol Chem. 1999 Sep 24;274(39):27975-80. - Yoshida T, Ishikawa I, Ono Y, Imai T, Suzuki R, Yoshie O.
An activation-responsive element in single C motif-1/lymphotactin promoter is a site of constitutive and inducible DNA-protein interactions involving nuclear factor of activated T cell.
J Immunol. 1999 Sep 15;163(6):3295-303. - Yoshida T, Izawa D, Nakayama T, Nakahara K, Kakizaki M, Imai T, Suzuki R, Miyasaka M, Yoshie O.
Molecular cloning of mXCR1, the murine SCM-1/lymphotactin receptor.
FEBS Lett. 1999 Sep 10;458(1):37-40. - Nagata K, Tanaka K, Ogawa K, Kemmotsu K, Imai T, Yoshie O, Abe H, Tada K, Nakamura M, Sugamura K, Takano S.
Selective Expression of a Novel Surface Molecule by Human Th2 Cells in vivo.
J Immunol. 1999 Feb 1;162(3):1278-86. - Tasaki Y, Fukuda S, Iio M, Miura R, Imai T, Sugano S, Yoshie O, Hughes A.L, Nomiyama H.
Chemokine PARC Gene (SCYA18) Generated by Fusion of Two MIP- 1alpha/LD78alpha-like Genes.
Genomics. 1999 Feb 1;55(3):353-7. - Tanaka Y, Imai T, Baba M, Ishikawa I, Uehira M, Nomiyama H, Yoshie O.
Selective expression of liver and activation-regulated chemokine (LARC) in intestinal epithelium in mice and humans.
Eur J Immunol. 1999 Feb;29(2):633-42. - Imai T, Nagira M, Takagi S, Kakizaki M, Nishimura M, Wang J, Gray P.W, Matsushima K, Yoshie O.
Selective recruitment of CCR4-bearing Th2 cells toward antigen- presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine.
Int Immunol. 1999 Jan;11(1):81-8.
1998
- Yoneyama H, Harada A, Imai T, Baba M, Yoshie O, Zhang Y, Higashi H, Murai M, Asakura H, Matsushima K.
Pivotal role of TARC, a CC chemokine, in bacteria-induced fulminant hepatic failure in mice.
J Clin Invest. 1998 Dec 1;102(11):1933-41. - Fong A.M, Robinson L.A, Steeber D.A, Tedder T.F, Yoshie O, Imai T, Patel D.D.
Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow.
J Exp Med. 1998 Oct 19;188(8):1413-9. - Nakajima T, Yamada H, Iikura M, Miyamasu M, Izumi S, Shida H, Ohta K, Imai T, Yoshie O, Mochizuki M, Schroder J.M, Morita Y, Yamamoto K, Hirai K.
Intracellular localization and release of eotaxin from normal eosinophils.
FEBS Lett. 1998 Sep 4;434(3):226-30. - Sozzani S, Allavena P, D'Amico G, Luini W, Bianchi G, Kitaura M, Imai T, Yoshie O, Bonecchi R, Mantovani A.
Differential regulation of chemokine receptors during dendritic cell migration: a model for their trafficking properties.
J Immunol. 1998 Aug 1;161(3):1083-6. - Nomiyama H, Amano K, Kusuda J, Imai T, Miura R, Yoshie O, Matsuda Y.
The human CC chemokine TECK (SCYA25) maps to chromosome 19p13.2.
Genomics. 1998 Jul 15;51(2):311-2. - Yoshida R, Nagira M, Imai T, Baba M, Takagi S, Tabira Y, Akagi J, Nomiyama H, Yoshie O.
EBI1-ligand chemokine (ELC) attracts a broad spectrum of lymphocytes: activated T cells strongly up-regulate CCR7 and efficiently migrate toward ELC.
Int Immunol. 1998 Jul;10(7):901-10. - Yoshida T, Imai T, Kakizaki M, Nishimura M, Takagi S, Yoshie O.
Identification of Single C Motif-1/Lymphotactin receptor XCR1.
J Biol Chem. 1998 Jun 26;273(26):16551-4. - Nagira M, Imai T, Yoshida R, Takagi S, Iwasaki M, Baba M, Tabira Y, Akagi J, Nomiyama H, Yoshie O.
A lymphocyte-specific CC chemokine, secondary lymphoid-tissue chemokine (SLC) is a highly efficient chemoattractant for B cells and activated T cells.
Eur J Immunol. 1998 May;28(5):1516-23. - Nomiyama H, Osborne L.R, Imai T, Kusuda J, Miura R, Tsui L C, Yoshie O.
Assignment of the human CC chemokine MPIF-2/eotaxin-2 (SCYA24) to chromosome 7q11.23.
Genomics. 1998 Apr 15;49(2):339-40. - Yoshida R, Nagira M, Kitaura M, Imagawa N, Imai T, Yoshie O.
Secondary lymphoid-tissue chemokine (SLC) is a functional ligand for the CC chemokine receptor CCR7.
J Biol Chem. 1998 Mar 20;273(12):7118-22. - Shoudai K, Hieshima K, Fukuda S, Iio M, Miura R, Imai T, Yoshie O, Nomiyama H.
Isolation of cDNA encoding a novel human CC chemokine NCC-4/LEC.
Biochim Biophys Acta. 1998 Mar 13;1396(3):273-7. - Imai T, Chantry D, Raport C.J, Wood C.L, Nishimura M, Godiska R, Yoshie O, Gray P.W.
Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4.
J Biol Chem. 1998 Jan 16;273(3):1764-8. - Nomiyama H, Imai T, Kusuda J, Miura R, Callen D.F, Yoshie O.
Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13.
Cytogenet Cell Genet. 1998;81(1):10-1.
1997
- Imai T, Hieshima K, Haskell C, Baba M, Nagira M, Nishimura M, Kakizaki M, Takagi S, Nomiyama H, Schall T.J, Yoshie O.
Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion.
Cell. 1997 Nov 14;91(4):521-30. - Hieshima K, Imai T, Baba M, Shoudai K, Ishizuka K, Nakagawa T, Tsuruta J, Takeya M, Sakaki Y, Takatsuki K, Miura R, Opdenakker G, Van Damme J, Yoshie O, Nomiyama H.
A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes.
J Immunol. 1997 Aug 1;159(3):1140-9. - Nagira M, Imai T, Hieshima K, Kusuda J, Ridanpaa M, Takagi S, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O.
Molecular cloning of a novel human CC chemokine secondary lymphoid- tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13.
J Biol Chem. 1997 Aug 1;272(31):19518-24. - Kawana Y, Komiya A, Ueda T, Nihei N, Kuramochi H, Suzuki H, Yatani R, Imai T, Dong J.T, Imai T, Yoshie O, Barrett J.C, Isaacs J.T, Shimazaki J, Ito H, Ichikawa T.
Location of KAI1 on the short arm of human chromosome 11 and frequency of allelic loss in advanced human prostate cancer.
Prostate. 1997 Aug 1;32(3):205-13. - Imai T, Baba M, Nishimura M, Kakizaki M, Takagi S, Yoshie O.
The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4.
J Biol Chem. 1997 Jun 6;272(23):15036-42. - Baba M, Imai T, Nishimura M, Kakizaki M, Takagi S, Hieshima K, Nomiyama H, Yoshie O.
Identification of CCR6, the specific receptor for a novel lymphocyte- directed CC chemokine LARC.
J Biol Chem. 1997 Jun 6;272(23):14893-8. - Yoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O.
Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7.
J Biol Chem. 1997 May 23;272(21):13803-9. - Nomiyama H, Imai T, Kusuda J, Miura R, Callen D.F, Yoshie O.
Assignment of the human CC chemokine gene TARC (SCYA17) to chromosome 16q13.
Genomics. 1997 Feb 15;40(1):211-3. - Hieshima K, Imai T, Opdenakker G, Van Damme J, Kusuda J, Tei H, Sakaki Y, Takatsuki K, Miura R, Yoshie O, Nomiyama H.
Molecular cloning of a novel human CC chemokine liver and activation- regulated chemokine (LARC) expressed in liver.
Chemotactic activity for lymphocytes and gene localization on chromosome 2.
J Biol Chem. 1997 Feb 28;272(9):5846-53.
1996
- Ueda T, Ichikawa T, Tamaru J, Mikata A, Akakura K, Akimoto S, Imai T, Yoshie O, Shiraishi T, Yatani R, Ito H, Shimazaki J.
Expression of the KAI1 protein in benign prostatic hyperplasia and prostate cancer.
Am J Pathol. 1996 Nov;149(5):1435-40. - Yoshida T, Imai T, Takagi S, Nishimura M, Ishikawa I, Yaoi T, Yoshie O.
Structure and expression of two highly related genes encoding SCM- 1/human lymphotactin.
FEBS Lett. 1996 Oct 14;395(1):82-8. - Imai T, Yoshida T, Baba M, Nishimura M, Kakizaki M, Yoshie O.
Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector.
J Biol Chem. 1996 Aug 30;271(35):21514-21. - Kitaura M, Nakajima T, Imai T, Harada S, Combadiere C, Tiffany H.L, Murphy P.M, Yoshie O.
Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3.
J Biol Chem. 1996 Mar 29;271(13):7725-30. - Baba M, Imai T, Yoshida T, Yoshie O.
Constitutive expression of various chemokine genes in human T-cell lines infected with human T-cell leukemia virus type 1: role of the viral transactivator Tax.
Int J Cancer. 1996 Mar 28;66(1):124-9.
1995
- Imai T, Kakizaki M, Nishimura M, Yoshie O.
Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82.
J Immunol. 1995 Aug 1;155(3):1229-39. - Takagi S, Fujikawa K, Imai T, Fukuhara N, Fukudome K, Minegishi M, Tsuchiya S, Konno T, Hinuma Y, Yoshie O.
Identification of a highly specific surface marker of T-cell acute lymphoblastic leukemia and neuroblastoma as a new member of the transmembrane 4 superfamily.
Int J Cancer. 1995 May 29;61(5):706-15. - Yoshida T, Imai T, Kakizaki M, Nishimura M, Yoshie O.
Molecular cloning of a novel C or gamma type chemokine, SCM-1.
FEBS Lett. 1995 Feb 27;360(2):155-9.
1994
- Nagira M, Imai T, Ishikawa I, Uwabe K.I, Yoshie O.
Mouse homologue of C33 antigen (CD82), a member of the transmembrane 4 superfamily: complementary DNA, genomic structure, and expression.
Cell Immunol. 1994 Aug;157(1):144-57.
1993
- Imai T, Tanaka Y, Fukudome K, Takagi S, Araki K, Yoshie O.
Enhanced expression of LFA-3 on human T-cell lines and leukemic cells carrying human T-cell-leukemia virus type 1.
Int J Cancer. 1993 Nov 11;55(5):811-6. - Imai T, Yoshie O.
C33 antigen and M38 antigen recognized by monoclonal antibodies inhibitory to syncytium formation by human T cell leukemia virus type 1 are both members of the transmembrane 4 superfamily and associate with each other and with CD4 or CD8 in T cells.
J Immunol. 1993 Dec 1;151(11):6470-81.
1992
- Imai T, Fukudome K, Takagi S, Nagira M, Furuse M, Fukuhara N, Nishimura M, Hinuma Y, Yoshie O.
C33 antigen recognized by monoclonal antibodies inhibitory to human T cell leukemia virus type 1-induced syncytium formation is a member of a new family of transmembrane proteins including CD9, CD37, CD53, and CD63.
J Immunol. 1992 Nov 1;149(9):2879-86. - Fukudome K, Furuse M, Fukuhara N, Orita S, Imai T, Takagi S, Nagira M, Hinuma Y, Yoshie O.
Strong induction of ICAM-1 in human T cells transformed by human T-cell- leukemia virus type 1 and depression of ICAM-1 or LFA-1 in adult T-cell- leukemia-derived cell lines.
Int J Cancer. 1992 Sep 30;52(3):418-27. - Furuse M, Fukudome K, Imai T, Uwabe K, Hinuma Y, Yoshie O.
Induction of strong homotypic adhesion in human T cell lines positive with human T-cell leukemia virus type 1 by monoclonal antibodies to MHC class I and beta 2-microglobulin.
Cell Immunol. 1992 Sep;143(2):298-309. - Fukudome K, Furuse M, Imai T, Nishimura M, Takagi S, Hinuma Y, Yoshie O.
Identification of membrane antigen C33 recognized by monoclonal antibodies inhibitory to human T-cell leukemia virus type 1 (HTLV-1)- induced syncytium formation: altered glycosylation of C33 antigen in HTLV-1-positive T cells.
J Virol. 1992 Mar;66(3):1394-401.