研究業績

2017年

  1. Spinal muscular atrophy carriers with two SMN1 copies. Ar Rochmah M, Awano H, Awaya T, Harahap NIF, Morisada N, Bouike Y, Saito T, Kubo Y, Saito K, Lai PS, Morioka I, Iijima K, Nishio H, Shinohara M. Brain Dev. 2017 Jul 1. pii: S0387-7604(17)30171-7. doi: 10.1016/j.braindev.2017.06.002. [Epub ahead of print] PMID: 28676237
  2. DMD transcripts in CRL-2061 rhabdomyosarcoma cells show high levels of intron retention by intron-specific PCR amplification. Niba ETE, Yamanaka R, Rani AQM, Awano H, Matsumoto M, Nishio H, Matsuo M. Cancer Cell Int. 2017 May 23;17:58. doi: 10.1186/s12935-017-0428-4. eCollection 2017. PMID: 28546788
  3. Genetic screening of spinal muscular atrophy using a real-time modified COP-PCR technique with dried blood-spot DNA. Ar Rochmah M, Harahap NIF, Niba ETE, Nakanishi K, Awano H, Morioka I, Iijima K, Saito T, Saito K, Lai PS, Takeshima Y, Takeuchi A, Bouike Y, Okamoto M, Nishio H, Shinohara M. Brain Dev. 2017 May 15. pii: S0387-7604(17)30134-1. doi: 10.1016/j.braindev.2017.04.015. [Epub ahead of print] PMID: 28522225
  4. SMA mutations in SMN Tudor and C-terminal domains destabilize the protein. Takarada T, Ar Rochmah M, Harahap NIF, Shinohara M, Saito T, Saito K, Lai PS, Bouike Y, Takeshima Y, Awano H, Morioka I, Iijima K, Nishio H, Takeuchi A. Brain Dev. 2017 Aug;39(7):606-612. doi: 10.1016/j.braindev.2017.03.002. Epub 2017 Mar 31. PMID: 28366534
  5. Cryptic splice activation but not exon skipping is observed in minigene assays of dystrophin c.9361+1G>A mutation identified by NGS. Niba ETE, Nishida A, Tran VK, Vu DC, Matsumoto M, Awano H, Lee T, Takeshima Y, Nishio H, Matsuo M. J Hum Genet. 2017 Apr;62(5):531-537. doi: 10.1038/jhg.2016.162. Epub 2017 Jan 19. PMID: 28100912
  6. Novel mechanism of regulation of the 5-lipoxygenase/leukotriene B4 pathway by high-density lipoprotein in macrophages. Tsuda S, Shinohara M, Oshita T, Nagao M, Tanaka N, Mori T, Hara T, Irino Y, Toh R, Ishida T, Hirata KI. Sci Rep. 2017 Oct 11;7(1):12989. doi: 10.1038/s41598-017-13154-0. PMID: 29021582
  7. High-density lipoprotein protects cardiomyocytes from oxidative stress via the PI3K/mTOR signaling pathway. Nagao M, Toh R, Irino Y, Nakajima H, Oshita T, Tsuda S, Hara T, Shinohara M, Ishida T, Hirata KI. FEBS Open Bio. 2017 Aug 14;7(9):1402-1409. doi: 10.1002/2211-5463.12279. eCollection 2017 Sep. PMID: 28904868
  8. Targeted Disruption of JCAD (Junctional Protein Associated With Coronary Artery Disease)/KIAA1462, a Coronary Artery Disease-Associated Gene Product, Inhibits Angiogenic Processes In Vitro and In Vivo. Hara T, Monguchi T, Iwamoto N, Akashi M, Mori K, Oshita T, Okano M, Toh R, Irino Y, Shinohara M, Yamashita Y, Shioi G, Furuse M, Ishida T, Hirata KI. Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1667-1673. doi: 10.1161/ATVBAHA.117.309721. Epub 2017 Jul 13. PMID: 28705794
  9. Eicosapentaenoic Acid-Enriched High-Density Lipoproteins Exhibit Anti-Atherogenic Properties. Tanaka N, Irino Y, Shinohara M, Tsuda S, Mori T, Nagao M, Oshita T, Mori K, Hara T, Toh R, Ishida T, Hirata KI. Circ J. 2017 Jun 23. doi: 10.1253/circj.CJ-17-0294. [Epub ahead of print] PMID: 28652532
  10. Association between Serum Elaidic acid Concentration and Insulin Resistance in Two Japanese Cohorts with Different Lifestyles. Itcho K, Yoshii Y, Ohno H, Oki K, Shinohara M, Irino Y, Toh R, Ishida T, Hirata KI, Yoneda M. J Atheroscler Thromb. 2017 May 9. doi: 10.5551/jat.39164. [Epub ahead of print] PMID: 28484112
  11. Combined metabolic and transcriptional profiling identifies pentose phosphate pathway activation by HSP27 phosphorylation during cerebral ischemia. Imahori T, Hosoda K, Nakai T, Yamamoto Y, Irino Y, Shinohara M, Sato N, Sasayama T, Tanaka K, Nagashima H, Kohta M, Kohmura E. Neuroscience. 2017 May 4;349:1-16. doi: 10.1016/j.neuroscience.2017.02.036. Epub 2017 Mar 6. PMID: 28257891
  12. Excessive intake of trans fatty acid accelerates atherosclerosis through promoting inflammation and oxidative stress in a mouse model of hyperlipidemia. Monguchi T, Hara T, Hasokawa M, Nakajima H, Mori K, Toh R, Irino Y, Ishida T, Hirata KI, Shinohara M. J Cardiol. 2017 Aug;70(2):121-127. doi: 10.1016/j.jjcc.2016.12.012. Epub 2017 Feb 21. PMID: 28254384
  13. NLRP3 Inflammasome Deficiency Protects Against Microbial Sepsis via Increased Lipoxin B4 Synthesis. Lee S, Nakahira K, Dalli J, Siempos II, Norris PC, Colas RA, Moon JS, Shinohara M, Hisata S, Howrylak JA, Suh GY, Ryter SW, Serhan CN, Choi AM. Am J Respir Crit Care Med. 2017 Feb 28. doi: 10.1164/rccm.201604-0892OC. [Epub ahead of print] PMID: 28245134
  14. G-CSF-induced sympathetic tone provokes fever and primes antimobilizing functions of neutrophils via PGE2. Kawano Y, Fukui C, Shinohara M, Wakahashi K, Ishii S, Suzuki T, Sato M, Asada N, Kawano H, Minagawa K, Sada A, Furuyashiki T, Uematsu S, Akira S, Uede T, Narumiya S, Matsui T, Katayama Y. Blood. 2017 Feb 2;129(5):587-597. doi: 10.1182/blood-2016-07-725754. Epub 2016 Nov 8. PMID: 27827823
  15. Enhanced Impact of Cholesterol Absorption Marker on New Atherosclerotic Lesion Progression After Coronary Intervention During Statin Therapy. Mori K, Ishida T, Tsuda S, Oshita T, Shinohara M, Hara T, Irino Y, Toh R, Hirata KI. J Atheroscler Thromb. 2017 Feb 1;24(2):123-132. doi: 10.5551/jat.32615. Epub 2016 Aug 4. PMID: 27487947

2016

  1. Alternative splicing of a cryptic exon embedded in intron 6 of SMN1 and SMN2. Yoshimoto S, Harahap NI, Hamamura Y, Ar Rochmah M, Shima A, Morisada N, Shinohara M, Saito T, Saito K, Lai PS, Matsuo M, Awano H, Morioka I, Iijima K, Nishio H. Hum Genome Var. 2016 Dec 1;3:16040. eCollection 2016. PMID: 27917293
  2. Early detection of tumor relapse/regrowth by consecutive minimal residual disease monitoring in high-risk neuroblastoma patients. Hirase S, Saitoh A, Hartomo TB, Kozaki A, Yanai T, Hasegawa D, Kawasaki K, Kosaka Y, Matsuo M, Yamamoto N, Mori T, Hayakawa A, Iijima K, Nishio H, Nishimura N. Oncol Lett. 2016 Aug;12(2):1119-1123. Epub 2016 Jun 7. PMID: 27446404
  3. Fluorescent protein-based detection of unconjugated bilirubin in newborn serum. Iwatani S, Nakamura H, Kurokawa D, Yamana K, Nishida K, Fukushima S, Koda T, Nishimura N, Nishio H, Iijima K, Miyawaki A, Morioka I. Sci Rep. 2016 Jun 21;6:28489. doi: 10.1038/srep28489. PMID: 27324682
  4. Telomeric Region of the Spinal Muscular Atrophy Locus Is Susceptible to Structural Variations. Noguchi Y, Onishi A, Nakamachi Y, Hayashi N, Harahap NI, Rochmah MA, Shima A, Yanagisawa S, Morisada N, Nakagawa T, Iijima K, Kasagi S, Saegusa J, Kawano S, Shinohara M, Tairaku S, Saito T, Kubo Y, Saito K, Nishio H. Pediatr Neurol. 2016 May;58:83-9. doi: 10.1016/j.pediatrneurol.2016.01.019. Epub 2016 Jan 30. PMID: 27268759
  5. HEK293 cells express dystrophin Dp71 with nucleus-specific localization of Dp71ab. Nishida A, Yasuno S, Takeuchi A, Awano H, Lee T, Niba ET, Fujimoto T, Itoh K, Takeshima Y, Nishio H, Matsuo M. Histochem Cell Biol. 2016 Sep;146(3):301-9. doi: 10.1007/s00418-016-1439-2. Epub 2016 Apr 25. PMID: 27109495
  6. Rare renal ciliopathies in non-consanguineous families that were identified by targeted resequencing. Yamamura T, Morisada N, Nozu K, Minamikawa S, Ishimori S, Toyoshima D, Ninchoji T, Yasui M, Taniguchi-Ikeda M, Morioka I, Nakanishi K, Nishio H, Iijima K. Clin Exp Nephrol. 2017 Feb;21(1):136-142. doi: 10.1007/s10157-016-1256-x. Epub 2016 Mar 11. PMID: 26968886
  7. Next-generation sequencing discloses a nonsense mutation in the dystrophin gene from long preserved dried umbilical cord and low-level somatic mosaicism in the proband mother. Taniguchi-Ikeda M, Takeshima Y, Lee T, Nishiyama M, Awano H, Yagi M, Unzaki A, Nozu K, Nishio H, Matsuo M, Kurahashi H, Toda T, Morioka I, Iijima K. J Hum Genet. 2016 Apr;61(4):351-5. doi: 10.1038/jhg.2015.157. Epub 2016 Jan 7. PMID: 26740235
  8. 2-Aminobutyric acid modulates glutathione homeostasis in the myocardium. Irino Y, Toh R, Nagao M, Mori T, Honjo T, Shinohara M, Tsuda S, Nakajima H, Satomi-Kobayashi S, Shinke T, Tanaka H, Ishida T, Miyata O, Hirata KI. Sci Rep. 2016 Nov 9;6:36749. doi: 10.1038/srep36749. PMID: 27827456
  9. Promotion of Intestinal Epithelial Cell Turnover by Commensal Bacteria: Role of Short-Chain Fatty Acids. Park JH, Kotani T, Konno T, Setiawan J, Kitamura Y, Imada S, Usui Y, Hatano N, Shinohara M, Saito Y, Murata Y, Matozaki T. PLoS One. 2016 May 27;11(5):e0156334. doi: 10.1371/journal.pone.0156334. eCollection 2016. PMID: 27232601
  10. Novel Endogenous Proresolving Molecules:Essential Fatty Acid-Derived and Gaseous Mediators in the Resolution of Inflammation. Shinohara M, Serhan CN. J Atheroscler Thromb. 2016 Jun 1;23(6):655-64. doi: 10.5551/jat.33928. Epub 2016 Apr 6. Review. PMID: 27052783