2016

Original Article

Hashimoto O, Yoshida M, Koma YI, Yanai T, Hasegawa D, Kosaka Y, Nishimura N, Yokozaki H.
Collaboration of cancer-associated fibroblasts and tumour-associated macrophages for neuroblastoma development
J. Pathol. 240(2): 211–223, 2016.

Takase N, Koma YI, Urakawa N, Nishio M, Arai N, Akiyama H, Shigeoka M, Kakeji Y, Yokozaki H.
NCAM- and FGF-2-mediated FGFR1 signaling in the tumor microenvironment of esophageal cancer regulates the survival and migration of tumor-associated macrophages and cancer cells
Cancer Lett. 380(1): 47–58, 2016.

Nishio M, Urakawa N, Shigeoka M, Takase N, Ichihara Y, Arai N, Koma Y, Yokozaki H.
Software-assisted morphometric and phenotype analyses of human peripheral blood monocyte-derived macrophages induced by a microenvironment model of human esophageal squamous cell carcinoma
Pathol. Int. 66(2): 83–93, 2016.

Review Article

横崎 宏,狛雄一朗,重岡 學,西尾真理
【慢性炎症とがん】 がん微小環境とがんの増殖・浸潤・転移 消化管がんの進展とがん間質
別冊BIO Clinica 慢性炎症と疾患 5(1): 77–81, 2016.

2015

Original Article

Urakawa N, Utsunomiya S, Nishio M, Shigeoka M, Takase N, Arai N, Kakeji Y, Koma Y, Yokozaki H.
GDF15 derived from both tumor-associated macrophages and esophageal squamous cell carcinomas contributes to tumor progression via Akt and Erk pathways
Lab. Invest. 95(5): 491–503, 2015.

Shigeoka M, Urakawa N, Nishio M, Takase N, Utsunomiya S, Akiyama H, Kakeji Y, Komori T, Koma Y, Yokozaki H.
Cyr61 promotes CD204 expression and the migration of macrophages via MEK/ERK pathway in esophageal squamous cell carcinoma
Cancer Med. 4(3): 437–446, 2015.

2014

Review Article

横崎 宏,仙波秀峰
消化管がん間質の特徴
病理と臨床 32(1): 51–56, 2014.

2013

Original Article

Shigeoka M, Urakawa N, Nakamura T, Nishio M, Watajima T, Kuroda D, Komori T, Kakeji Y, Semba S, Yokozaki H.
Tumor associated macrophage expressing CD204 is associated with tumor aggressiveness of esophageal squamous cell carcinoma
Cancer Sci. 104(8): 1112–1119, 2013.

2012

Original Articles

Nishimura K, Semba S, Aoyagi K, Sasaki H, Yokozaki H.
Mesenchymal stem cells provide an advantageous tumor microenvironment for the restoration of cancer stem cells.
Pathobiology 79(6): 290–306, 2012.

Yusra, Semba S, Yokozaki H.
Biological significance of tumor budding at the invasive front of human colorectal carcinoma cells.
Int. J. Oncol. 41(1): 201–210, 2012.

Tanaka S, Morita Y, Fujita T, Yokozaki H, Obata D, Fujiwara S, Wakahara C, Masuda A, Sugimoto M, Sanuki T, Yoshida M, Toyonaga T, Kutsumi H, Azuma T.
Clinicopathological characteristics of abnormal micro-lesions at the oro-hypopharynx detected by a magnifying narrow band imaging system.
Dig. Endosc. 24(2): 100–109, 2012.

Review Article

仙波秀峰
胃癌細胞と線維芽細胞・間葉系幹細胞の相互作用
胃がんperspective 5(1): 14–23, 2012.

2011

Original Articles

Watanabe T, Semba S, Yokozaki H.
Regulation of PTEN expression by the SWI/SNF chromatin-remodelling protein BRG1 in human colorectal carcinoma cells.
Br. J. Cancer 104(1): 146–154, 2012.

Hashimoto O, Shimizu K, Semba S, Chiba S, Ku Y, Yokozaki H, Hori Y.
Hypoxia induces tumor aggressiveness and the expansion of CD133-positive cells in a hypoxia-inducible factor-1α-dependent manner in pancreatic cancer cells.
Pathobiology 78(4): 181–192, 2011.

Funakoshi Y, Matsuoka H, Yamamoto K, Yakushijin K, Inui Y, Okamura A, Takeuchi M, Yokozaki H, Minami H.
Therapy-related pure erythroid leukemia with hepatic infiltration and hemophagocytic syndrome.
Intern. Med. 50(24): 3031–3035, 2011.

Review Article

横崎 宏,仙波秀峰
多発胃癌の病理学的特徴 分子病理学的立場から
胃と腸 46(1): 23–29, 2011.

2010

Original Articles

Semba S, Mizuuchi E, Yokozaki H.
Requirement of phosphatase of regenerating liver-3 for the nucleolar localization of nucleolin during the progression of colorectal carcinoma.
Cancer. Sci. 101(10): 2254–2261, 2010.

Maeda N, Semba S, Nakayama S, Yanagihara K, Yokozaki H.
Loss of WW domain-containing oxidoreductase expression in the progression and development of gastric carcinoma: clinical and histopathologic correlations.
Virchows. Arch. 457(4): 423–432, 2010.

Matsukawa Y, Semba S, Kato H, Koma Y, Yanagihara K, Yokozaki H.
Constitutive suppression of PRL-3 inhibits invasion and proliferation of gastric cancer cell in vitro and in vivo.
Pathobiology 77(3): 155–162, 2010.

Masuda R, Semba S, Mizuuchi E, Yanagihara K, Yokozaki H.
Negative regulation of the tight junction protein tricellulin by snail-induced epithelial-mesenchymal transition in gastric carcinoma cells.
Pathobiology 77(2): 106–113, 2010.

Wakahashi K, Shimoyama M, Katayama Y, Minagawa K, Yoshida K, Sasaki R, Nakayama S, Yokozaki H, Yanagita E, Itoh T, Hayashi Y, Matsui T.
Histiocytic sarcoma with two immunohistopathologically distinct populations.
Int. J. Hematol. 92(4): 642–646, 2010.

Morioka I, Fujibayashi H, Enoki E, Yokoyama N, Yokozaki H, Matsuo M.
Congenital pneumonia with sepsis caused by intrauterine infection of Ureaplasma parvum in a term newborn: a first case report.
J. Perinatol. 30(5): 359–362, 2010.

Book

横崎 宏,仙波秀峰
増殖因子:改訂版 新編スキルス胃癌 基礎と臨床.
曽和融生,井藤久雄(編),医薬ジャーナル社 p.131–136. 2010.

2009

Original Articles

Nakayama, S., Semba, S., Maeda, N., Matsushita, M., Kuroda, Y. and Yokozaki, H.
Hypermethylation-mediated reduction of WWOX expression in intraductal papillary mucinous neoplasms of the pancreas.
Br. J. Cancer 100(9): 1438–1443, 2009.

Omori, Y., Nakayama, F., Li, D., Kanemitsu, K., Semba, S., Ito, A. and Yokozaki, H.
Alternative lengthening of telomeres frequently occurs in mismatch repair system-deficient gastric carcinoma.
Cancer Sci. 100(3): 413–418, 2009.

Mizuuchi, E., Semba, S., Kodama, Y. and Yokozaki, H.
Down-modulation of keratin 8 phosphorylation levels by PRL-3 contributes to colorectal carcinoma progression.
Int. J. Cancer 124(8):1802–1810, 2009.

Semba, S., Satake, S., Matsushita, M. and Yokozaki, H.
Phosphatase activity of nuclear PTEN is required for CDX2-mediated intestinal differentiation of gastric carcinoma.
Cancer Lett. 274(1): 143–150, 2009.

2008

Original Articles

Semba, S., Yasujima, H., Takano, T. and Yokozaki, H.
Autopsy case of the neonatal form of carnitine palmitoyltransferase-II deficiency triggered by a novel disease-causing mutation del1737C.
Pathol. Int. 58(7): 436–441, 2008.

Nakayama, F., Semba, S., Usami, Y., Chiba, H., Sawada, N. and Yokozaki, H.
Hypermethylation-modulated downregulation of claudin-7 expression promotes the progression of colorectal carcinoma.
Pathobiology 75(3): 177–185, 2008.

Usami, Y., Satake, S., Nakayama, F., Matsumoto, M., Ohnuma, K., Komori, T., Semba, S., Ito, A., and Yokozaki, H.
Snail-associated epithelial-mesenchymal transition promotes oesophageal squamous cell carcinoma motility and progression.
J. Pathol. 215(3): 330–339, 2008.

Semba, S., Hasuo, T., Satake, S., Nakayama, F. and Yokozaki, H.
Prognostic significance of intestinal claudins in high-risk synchronous and metachronous multiple gastric epithelial neoplasias after initial endoscopic submucosal dissection.
Pathol. Int. 58(6): 371–377, 2008.

Koma, Y., Furuno, T., Hagiyama, M., Hamaguchi, K., Nakanishi, M., Masuda, M., Hirota, S., Yokozaki, H. and Ito, A.
Cell adhesion molecule 1 is a novel pancreatic-islet cell adhesion molecule that mediates nerve-islet cell interactions.
Gastroenterology 134(5): 1544–1554, 2008.

Nakayama S, Semba S, Maeda N, Aqeilan RI, Huebner K. and Yokozaki H.
Role of the WWOX gene, encompassing fragile region FRA16D, in suppression of pancreatic carcinoma cells.
Cancer Sci. 99(7): 1370–1376, 2008.

and others...

研究室概要

所在地

650-0017
兵庫県神戸市中央区楠町7-5-1
神戸大学大学院医学研究科
病理学講座病理学分野
(研究棟C 3階 西側)
TEL: (078) 382-5465
FAX: (078) 382-5479