業績一覧

Utsumi T, Lusida MI, Dinana Z, Wahyuni RM, Yamani LN, Juniastuti, Soetjipto, Matsui C, Deng L, Abe T, Doan YH, Fujii Y, Kimura H, Katayama K, and Shoji I. Occurence of norovirus infection in an asymptomatic population in Indonesia. Infection, Genetics and Evolution, 2017, 55, 1-7.

Minami N, Abe T, Deng L, Matsui C, Fukuhara T, Matsuura Y, and Shoji I. Unconjugated interferon-stimulated gene 15 specifically interacts with the hepatitis C virus NS5A protein via domain I. Microbiology and Immunology, 2017, 61 (7): 287-292.

Kawaguchi Y, Taoka M, Takekiyo T, Uekita T, Shoji I, Hachiya N, and Ichimura T. TRIM32-cytoplasmic-body formation is an ATP-requiring process stimulated by HSP70 ATPase function in cells. PLoS One, 2017, 12 (1): e0169436.

Aizawa S, Okamoto T, Sugiyama Y, Kouwaki T, Ito A, Suzuki T, Ono C, Fukuhara T, Yamamoto M, Okochi M, Hiraga N, Imamura M, Chayama K, Suzuki R, Shoji I, Moriishi K, Moriya K, Koike K, and Matsuura Y. TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis. Nature Communications, 2016, 7:11379.

Chen M, Gan X, Yoshino K, Kitagawa M, Shoji I, Deng L, and Hotta H. Hepatitis C virus NS5A protein interacts with lysine methyltransferase SET and MYND domain-containing 3 and induces activator protein 1 activation. Microbiology and Immunology, 2016, 60: 407-17.

Hayashi M, Deng L, Chen M, Gan X, Shinozaki K, Shoji I, and Hotta H. Interaction of the hepatitis B virus X protein with the lysine methyltransferase SET and MYND domain-containing 3 induces activator protein 1 activation. Microbiology and Immunology, 2016, 60: 17-25.

Deng L, Chen M, Shoji I, and Hotta H. HCV upregulates Bim through the ROS/JNK signaling pathway, leading to Bax-mediated apoptosis. Journal of General Virology, 2015, 96: 2670-83.

Sianipar IR, Matsui C, Minami N, Gan X, Deng L, Hotta H, and Shoji I. Physical and functional interaction between hepatitis C virus NS5A protein and ovarian tumor protein deubiquitinase 7B. Microbiology and Immunology., 2015, 59: 466-76.

Matsui C, Sianipar IR, Minami N, Deng L, Hotta H, and Shoji I. A single-amino-acid mutation in hepatitis C virus NS5A disrupts physical and functional interaction with the transcription factor HNF-1α. Journal of General Virology, 2015, 96: 2200-05.

Ratnoglik SL, Jang DP, Aoki C, Sudarmono P, Shoji I, Deng L, and Hotta H. Induction of cell-mediated immune responses in mice by DNA vaccines that express hepatitis C virus NS3 mutants lacking serine protease and NTPase/RNA helicase activities., PLoS One, 2014, 9 (6): e98877.

Ratnoglik, SL., Aoki, C., Sudarmono, P., Komoto, M., Deng, L., Shoji, I., Fuchino, H., Kawahara, N., and Hotta, H. Antiviral activity of extracts from Morinda citrifolia leaves and chlorophyll catabolites pheophorbide a and pyropheophorbide a, against hepatitis C virus. Microbiology and Immunology, 2014, 58 (3): 188-94.

Adianti, M., Aoki, C., Komoto, M., Deng, L., Shoji, I., Wahyuni, T., Lusida, M., Soetjipto, S., Fuchino, H., Kawahara, N., and Hotta, H. Anti-hepatitis C virus compounds obtained from Glycyrrhiza uralensis and other Glycyrrhiza species. Microbiology and Immunology, 2014, 58 (3): 180-7.

Tao RR, Huang JY, Lu YM, Hong LJ, Wang H, Masood MA, Ye WF, Zhu DY, Huang Q, Fukunaga K, Lou YJ, Shoji I, Wilcox CS, Lai EY, Han F. Nitrosative stress induces peroxiredoxin 1 ubiquitination during ischemic insult via E6AP activation in endothelial cells both in vitro and in vivo. Antioxidants & Redox Signaling, 2014, 21 (1): 1-16.

Mawatari, S., Uto, H., Ido, A., Nakashima, K., Suzuki, T., Kanmura, S., Kumagai, K., Oda, K., Tabu, K., Tamai, T., Moriuchi, A., Oketani, M., Shimada, Y., Sudoh, M., Shoji, I., and Tsubouchi, H. Hepatitis C virus NS3/4A protease inhibits complement activation by cleaving complement component 4., PLoS One, 2013, 8 (12): e82094.

Wahyuni, TS., Tumewu, L., Permanasari, AA., Apriani, E., Adianti, M., Rahman, A., Widyawaruyanti, A., Lusida, MI., Fuad, A., Soetjipto, Nasronudin, Fuchino, H., Kawahara, N., Shoji, I., Deng, L., Aoki, C., and Hotta H. Antiviral activities of Indonesian medicinal plants in the East Java region against hepatitis C virus. VirologyJournal, 10 (1):259, 1-9, 2013.

Ichimura, T., Taoka, M., Shoji, I., Kato, H., Hatakeyama, S., Isobe, T., and Hachiya, N. 14-3-3 Proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitination and cytoplasmic body formation., Journal of Cell Science, 126 (Pt9): 2014-26, 2013.

El-Shamy, A., Shindo, M., Shoji, I., Deng, L., Okuno, T., and Hotta, H. Polymorphisms of the Core, NS3 and NS5A proteins of hepatitis C virus genotype 1b associate with development of hepatocellular carcinoma, Hepatology, 58 (2): 555-63, 2013.

El-Shamy, A., Shoji, I., El-Akel, W., Bilasy SE, Deng, L., El-Raziky, M., Jiang, D., Esmat, G., and Hotta, H. NS5A sequence heterogeneity of hepatitis C virus genotype 4a predicts clinical outcome of pegylated-interferon/ribavirin therapy in Egyptian patients., J Clinical Microbiology, 50 (12): 3886-92, 2012.

Matsui, C., Shoji, I., Kaneda, S., Sianipar, IR., Deng, L., and Hotta, H. Hepatitits C virus infection suppresses GLUT2 gene expression via down-regulation of hepatocyte nuclear factor 1α. Journal of Virology, 86 (23): 12903-11, 2012.

Nakashima, K., Takeuchi, K., Chihara, K., Deng, L., Shoji, I., Hotta, H., and Sada, K. HCV NS5A protein containing potential ligands for both Src homology 2 and 3 domains enhances autophosphorylation of Src family kinases Fyn in B cells., PLoS One, 7 (10):e46634, 2012.

Kim, S-R., El-Shamy, A., Imoto, S., Kim, KI., Ide, Y-H., Deng, L., Shoji, I., Tanaka, Y., Hasegawa, Y., Ota, Mitsuhiro., and Hotta, H. Prediction of response to pegylated inferferon/ribavirin combination therapy for chronic hepatitis C genotype 1b and high viral load., Journal of Gastroenterology, 47 (10): 1143-51, 2012.

El-Shamy, A., Shoji, I., Kim S-R., Ide, Y-H., Imoto, S., Deng, L., Yoon, S., Fujisawa, T., Tani, S., Yano, Y., Seo, Y., Azuma, T., and Hotta, H. Sequence heterogeneity in NS5A of hepatitis C virus gentypes 2a and 2b and clinical outcome of pegylated-Interferon/Ribavirin therapy., PLoS One, 7, e30513, 1-10, 2012.

Sasayama, M., Shoji, I., Adianti M, Jiang DP, Deng, L, Saito T, Watanabe H, Kawata S, Aoki C, and Hotta, H. A point mutation at Asn-534 that disrupts a conserved N-glycosylation motif of the E2 glycoprotein of hepatitis C virus markedly enhances the sensitivity to antibody neutralization. Journal of Medical Virology, 84, 229-34, 2012.

Kamada, K., Shoji, I., Deng, L, Wakita, T., and Hotta, H. Generation of a recombinant reporter hepatitis C virus useful for the analyses of virus entry, intra-cellular replication and virion production. Microbes and Infection, 14, 69-78, 2012.

El-Shamy, A., Ide, Y-H., Kim, SR., Sasase, N., Imoto, S., Deng, L., Shoji, I., and Hotta, H. Polymorphisms of hepatitis C virus NS5A and core proteins and clinical outcome of pegylated interferon/ribavirin therapy. Intervirology, 55, 1-11, 2012.

Deng, L., Shoji, I., Oawa, W., Kaneda, S., Soga, T., Jiang, D. P., Ide, Y-H., and Hotta, H., Hepatitis C virus infection promotes hepatic gluconeogenesis through an NS5A-mediated, FoxO1-dependent pathway. Journal of Virology, 85, 8556-68, 2011.

Yamagishi, Y., Shoji, I., Miyagawa, S., Kawakami, T., Katoh, T., Goto, Y., and Suga, H. Natural product-like macrocyclic N-methyl-peptide inhibitors against a ubiquitin ligase uncovered from a ribosome-expressed de novo library. Chemistry & Biology, 18, 1562-1570, 2011.

El-Shamy, A., Shoji, I., Saito, T., Watanabe H., Ide, Y-H., Deng, L., Kawata, S., and Hotta, H. Sequence heterogeneity of NS5A and core proteins of hepatitis C virus and virological responses to Pegylated-Interferon/Ribavirin combination therapy. Microbiology and Immunology, 55, 418-26, 2011.

Inoue, Y., Aizaki, H., Hara, H., Matsuda, M., Ando, T., Shimoji, T., Murakami, K., Masaki, T., Shoji, I., Homma, S., Matsuura, Y., Miyamura, T., Lai, MMC, Wakita, T., and Suzuki, T. Chaperonin TRiC/CCT participates in replication of hepatitis C virus genome via interaction with the viral NS5B protein. Virology, 410, 38-47, 2011.

Hayashida K, Shoji, I., Deng, L., Ide, Y-H., and Hotta, H. 17-Estradiol inhibits the production of infectious particles of hepatitis C virus. Microbiology and Immunology, 54, 684-90, 2010.

Kim SR., Imoto S., Kudo M., Nakajima T., Ando K., Mita K., Fukuda K., Hong HS., Lee YH., Nakashima K., Shoji I., Nagano-Fujii M., Hotta H., and Hayashi Y. Autoimmune thrombocytopenic purpura during pegylated Interferon α treatment for chronic hepatitis C. Internal Medicine, 49, 1119-1122, 2010.

Nasu, J., Murakami, K., Miyagawa, S., Yamashita, R., Ichimura, T., Wakita, T., Hotta, H., Miyamura, T., Suzuki, T., Satoh, T., and Shoji, I. E6AP ubiquitin ligase mediates ubiquitin-dependent degradation of peroxiredoxin 1. Journal of Cellular Biochemistry, 111, 676-85, 2010.

Moriishi K., Shoji, I., Mori, Y., Suzuki, R., Suzuki, T., Kataoka, C., and Matsuura, Y. Involvement of PA28γ in the propagation of hepatitis C virus. Hepatology, 52 411-420 2010.

Sanjo M., Saito, T., Ishii, R., Nishise, Y., Haga, H., Okumoto, K., Ito, J., Watanabe, H., Saito, K., Togashi, H., Fukuda, K., Imai, Y., El-Shamy, A., Deng, L., Shoji, I., Hak, H., and Kawata, S. Secondary structure of the amino-terminal region of HCV NS3 and virological response to pegylated interferon plus ribavirin therapy for chronic hepatitis C. Journal of Medical Virology, 82, 1364-70, 2010.

Sasayama, M., Deng, L., Kim, SR., Ide Y-H., Shoji, I., and Hotta, H. Analysis of neutralizing antibodies against hepatitis C virus in patients who were treated with peglated-Interferon plus ribavirin. Kobe Journal of Medical Sciences, 56, E60-E66, 2010.

Kim, SR., Imoto, S., Kudo, M., Mita, K., Taniguchi, M., Kim, KI., Sasase, N., Shoji, I., Nagano, M., El-Shamy, A., Hotta, H., Nagai, T., Nagata, Y., and Hayashi, Y. Double filtration plasmapheresis plus interferon treatment for non-sustained virological response to previous combination therapy: Early viral dynamics. Intervirology, 53, 44-48, 2010.

Sasase, N., Kim, SR., Kudo, M., Kim, KI., Taniguchi, M., Imoto, S., Mita, K., Hayashi, Y., Shoji, I., El-Shamy, A., and Hotta, H. Outcome and early viral dynamics with viral mutation in PEG-IFN/RBV combination therapy for chronic hepatitis in patients with high viral loads of serum HCV RNA genotype 1b. Intervirology, 53, 49-54, 2010.

An, C., Ide Y., Nagano-Fujii, M., Kitazawa, S., Shoji, I., and Hotta, H. A transgenic mouse line with a 58-kb fragment deletion in chromosome 11E1 that encompasses part of the Fam20a gene and its upstream region shows growth disorder. Kobe Journal of Medical Sciences, 55, 82-92, 2010.

Bungyoku, Y., Shoji, I., Makine, T., Adachi, T., Hayashida, K., Nagano-Fujii, M., Ide Y., Deng, L., and Hotta, H. Efficient production of infectious hepatitis C virus with adaptive mutations in cultured hepatoma cells. Journal of General Virology, 90, 1681-91, 2009.

Hara, H., Aizaki, H., Matsuda, M., Shinkai-Ouchi, F., Inoue, Y., Murakami, K., Shoji, I., Kawakami, H., Matsuura, Y., Lai, MMC., Miyamura, T., Wakita, T., and Suzuki, T. Involvement of creatine kinase B in hepatitis C virus genome replication through interaction with the viral NS4A protein. Journal of Virology, 83, 5137-47, 2009.

Jian, D.P., Ide, Y., Nagano-Fujii, M., Shoji, I., and Hotta, H. Single-point mutations of the M protein of a measles virus variant obtained from a patient with subacute sclerosing panencephalitis critically affect solubility and subcellular localization of the M protein and cell-free virus production. Microbes and Infection, 11, 467-75, 2009.

Shimoji, T., Murakami, K., Sugiyama, Y., Matsuda, M., Inubushi, S., Nasu, J., Shirakura, M., Suzuki, T., Wakita, T., Kishino, T., Hotta, H., Miyamura, T., and Shoji, I., Identification of annexin A1 as a novel substrate for E6AP-mediated ubiquitylation. Journal of Cellular Biochemistry, 106, 1123-1135, 2009.

Kasai, D., Adachi, T., Lin, D., Nagano-Fujii, M., Sada, K., Ikeda, M., Kato, N., Ide, Y., Shoji, I., and Hotta, H. HCV replication suppresses cellular glucose uptake through down-regulation of cell surface expression of glucose transporters.Journal ofHepatology, 50, 883-94, 2009.

Suzuki, R., Moriishi, K., Fukuda, K., Shirakura, M., Ishii, K., Shoji, I., Wakita, T., Miyamura, T., Matsuura, Y., and Suzuki, T. Proteasomal turnover of hepatitis C virus core protein is regulated by dual mechanisms, ubiquitin-dependent and ubiquitin-independent but PA28g-dependent. Journal of Virology, 83, 2389-2392, 2009.

Deng, L., Adachi, T., Kitayama, K., Bungyoku, Y., Kitazawa, S., Ishido, S., Shoji, I., and Hotta, H. Hepatitis C virus infection induces apoptosis through a Bax-triggered, mitochondria-mediated, Caspase-3-dependent pathway. Journal of Virology, 82, 10375-85, 2008.

Sasase, N., Kim, S.R., Kim, K.I., Taniguchi, M., Imoto, S., Mita, K., Hotta, H., Shoji, I., El-Shamy, A., Kawada, N., Kudo, M., and Hayashi, Y. Usefulness of a new immunoradiometric assay of HCV core antigen to predict virological response during PEG-IFN/RBV combination therapy for chronic hepatitis with high viral load of serum HCV RNA genotype 1b. Intervirology, 51, 70-5, 2008.

Murakami, K., Kimura, T., Osaki, M., Ishii, K., Miyamura, T., Suzuki, T., Wakita, T., and Shoji, I. Virological characterization of the HCV JFH-1 strain in lymphocytic cell lines. Journal of General Virology, 89, 1587-92, 2008.

Murakami, K., Inoue, Y., Hmwe, S.S., Omata, K., Hongo, T., Ishii, K., Yoshizaki, S., Aizaki, H., Matsuura, T., Shoji, I., Miyamura, T., and Suzuki, T. Dynamic behavior of hepatitis C virus quasispecies in a long-term culture of the three-dimensional radial-flow bioreactor system. Journal of Virological Methods, 148, 174-181, 2008.

Shirakura, M., Murakami, K., Ichimura, T., Suzuki, R., Shimoji, T., Fukuda, K., Abe, K., Sato, S., Fukasawa, M., Yamakawa, Y., Nishijima, M., Moriishi, K., Matsuura, Y., Wakita, T., Suzuki, T., Howley, P.M., Miyamura, T, and Shoji, I. E6AP ubiquitin ligase mediates ubiquitylation and degradation of hepatitis C virus core protein. Journal of Virology, 81, 1174-1185, 2007.

Sato, S., Fukasawa, M., Yamakawa, Y., Natsume, T., Suzuki, T., Shoji, I., Aizaki, H., Miyamura, T., and Nishijima, M. Proteomic profiling of lipid droplet proteins in hepatoma cell lines expressing hepatitis C virus core protein. Journal of Biochemistry, 139, 921-30, 2006.

Murakami, K., Ishii, K., Ishihara, Y., Yoshizaki, S., Tanaka, K., Gotoh, Y., Aizaki, H., Kohara, M., Yoshioka, H., Mori, Y., Manabe, N., Shoji, I., Sata, T., Bartenschlager, R., Matsuura, Y., Miyamura, T., and Suzuki, T. Production of infectious hepatitis C virus particles in three-dimensional cultures of the cell line carrying the genome-length dicistronic viral RNA of genotype 1b. Virology, 351, 381-92, 2006.