研究業績

2021年

  1. A lack of ChREBP inhibits mitochondrial cristae formation in brown adipose tissue. Sakiyama H, Li L, Kuwahara-Otani S, Nakagawa T, Eguchi H, Yoshihara D, Shinohara M, Fujiwara N, Suzuki K. Mol Cell Biochem. 2021 May 21. doi: 10.1007/s11010-021-04178-2. Online ahead of print. PMID: 34021470
  2. Effect of Oral Tributyrin Treatment on Lipid Mediator Profiles in Endotoxin-Induced Hepatic Injury. Miyoshi M, Usami M, Kajita A, Kai M, Nishiyama Y, Shinohara M. Kobe J Med Sci. 2020 Dec 16;66(4):E129-E138. PMID: 33994516
  3. Phenotypes of SMA patients retaining SMN1 with intragenic mutation. Wijaya YOS, Ar Rohmah M, Niba ETE, Morisada N, Noguchi Y, Hidaka Y, Ozasa S, Inoue T, Shimazu T, Takahashi Y, Tozawa T, Chiyonobu T, Inoue T, Shiroshita T, Yokoyama A, Okamoto K, Awano H, Takeshima Y, Saito T, Saito K, Nishio H, Shinohara M. Brain Dev. 2021 Aug;43(7):745-758. doi: 10.1016/j.braindev.2021.03.006. Epub 2021 Apr 20. PMID: 33892995
  4. Dried Blood Spot Screening System for Spinal Muscular Atrophy with Allele-Specific Polymerase Chain Reaction and Melting Peak Analysis. Wijaya YOS, Nishio H, Niba ETE, Shiroshita T, Kato M, Bouike Y, Tode C, Ar Rochmah M, Harahap NIF, Nurputra DK, Okamoto K, Saito T, Takeuchi A, Lai PS, Yamaguchi S, Shinohara M. Genet Test Mol Biomarkers. 2021 Apr;25(4):293-301. doi: 10.1089/gtmb.2020.0312. PMID: 33877896
  5. Canagliflozin ameliorates hepatic fat deposition in obese diabetic mice: Role of prostaglandin E2. Yoshino K, Hosooka T, Shinohara M, Aoki C, Hosokawa Y, Imamori M, Ogawa W. Biochem Biophys Res Commun. 2021 Jun 11;557:62-68. doi: 10.1016/j.bbrc.2021.04.012. Epub 2021 Apr 13. PMID: 33862461
  6. Accessory pathway analysis using a multimodal deep learning model. Nishimori M, Kiuchi K, Nishimura K, Kusano K, Yoshida A, Adachi K, Hirayama Y, Miyazaki Y, Fujiwara R, Sommer P, El Hamriti M, Imada H, Takemoto M, Takami M, Shinohara M, Toh R, Fukuzawa K, Hirata KI. Sci Rep. 2021 Apr 13;11(1):8045. doi: 10.1038/s41598-021-87631-y. PMID: 33850245
  7. Pemafibrate, A Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator, Reduces Plasma Eicosanoid Levels and Ameliorates Endothelial Dysfunction in Diabetic Mice. Suto K, Fukuda D, Shinohara M, Ganbaatar B, Yagi S, Kusunose K, Yamada H, Soeki T, Hirata KI, Sata M. J Atheroscler Thromb. 2021 Mar 27. doi: 10.5551/jat.61101. Online ahead of print. PMID: 33775978
  8. Estimating Incidence of Acute Heart Failure Syndromes in Japan - An Analysis From the KUNIUMI Registry. Fujimoto W, Toh R, Takegami M, Hayashi T, Kuroda K, Hatani Y, Yamashita S, Imanishi J, Iwasaki M, Inoue T, Okamoto H, Okuda M, Konishi A, Shinohara M, Murata S, Ogata S, Nishimura K, Hirata KI. Circ J. 2021 Mar 5. doi: 10.1253/circj.CJ-20-1154. Online ahead of print. PMID: 33678754
  9. Geranylgeranylacetone attenuates cerebral ischemia-reperfusion injury in rats through the augmentation of HSP 27 phosphorylation: a preliminary study. Matsuo K, Hosoda K, Tanaka J, Yamamoto Y, Imahori T, Nakai T, Irino Y, Shinohara M, Sasayama T, Kohmura E. BMC Neurosci. 2021 Feb 8;22(1):9. doi: 10.1186/s12868-021-00614-7. PMID: 33557752
  10. Mobilization efficiency is critically regulated by fat via marrow PPARδ. Suzuki T, Ishii S, Shinohara M, Kawano Y, Wakahashi K, Kawano H, Sada A, Minagawa K, Hamada M, Takahashi S, Furuyashiki T, Tan NS, Matsui T, Katayama Y. Haematologica. 2021 Jun 1;106(6):1671-1683. doi: 10.3324/haematol.2020.265751. PMID: 33538151
  11. Glioma cells require one-carbon metabolism to survive glutamine starvation. Tanaka K, Sasayama T, Nagashima H, Irino Y, Takahashi M, Izumi Y, Uno T, Satoh N, Kitta A, Kyotani K, Fujita Y, Hashiguchi M, Nakai T, Kohta M, Uozumi Y, Shinohara M, Hosoda K, Bamba T, Kohmura E. Acta Neuropathol Commun. 2021 Jan 19;9(1):16. doi: 10.1186/s40478-020-01114-1. PMID: 33468252
  12. Metabolic changes and anti-tumor effects of a ketogenic diet combined with anti-angiogenic therapy in a glioblastoma mouse model. Maeyama M, Tanaka K, Nishihara M, Irino Y, Shinohara M, Nagashima H, Tanaka H, Nakamizo S, Hashiguchi M, Fujita Y, Kohta M, Kohmura E, Sasayama T. Sci Rep. 2021 Jan 8;11(1):79. doi: 10.1038/s41598-020-79465-x. PMID: 33420169
  13. Precipitating factors and clinical impact of early rehospitalization for heart failure in patients with heart failure in Awaji Island, Japan. Fujimoto W, Konishi A, Iwasaki M, Toh R, Shinohara M, Hamana T, Kuroda K, Hatani Y, Yamashita S, Imanishi J, Inoue T, Okamoto H, Okuda M, Hayashi T, Hirata KI. J Cardiol. 2021 Jun;77(6):645-651. doi: 10.1016/j.jjcc.2020.12.014. Epub 2021 Jan 5. PMID: 33419613
  14. Critical role of glutamine metabolism in cardiomyocytes under oxidative stress. Watanabe K, Nagao M, Toh R, Irino Y, Shinohara M, Iino T, Yoshikawa S, Tanaka H, Satomi-Kobayashi S, Ishida T, Hirata KI. Biochem Biophys Res Commun. 2021 Jan 1;534:687-693. doi: 10.1016/j.bbrc.2020.11.018. Epub 2020 Nov 17. PMID: 33213841

2020年

  1. Assessment of Spinal Muscular Atrophy Carrier Status by Determining SMN1 Copy Number Using Dried Blood Spots. Wijaya YOS, Purevsuren J, Harahap NIF, Niba ETE, Bouike Y, Nurputra DK, Rochmah MA, Thursina C, Hapsara S, Yamaguchi S, Nishio H, Shinohara M. Int J Neonatal Screen. 2020 May 29;6(2):43. doi: 10.3390/ijns6020043. eCollection 2020 Jun. PMID: 33073034
  2. A Novel System for Spinal Muscular Atrophy Screening in Newborns: Japanese Pilot Study. Shinohara M, Niba ETE, Wijaya YOS, Takayama I, Mitsuishi C, Kumasaka S, Kondo Y, Takatera A, Hokuto I, Morioka I, Ogiwara K, Tobita K, Takeuchi A, Nishio H; SMA-NBS PILOT STUDY GROUP. Int J Neonatal Screen. 2019 Nov 12;5(4):41. doi: 10.3390/ijns5040041. eCollection 2019 Dec. PMID: 33072999
  3. Clinical phenotypes of spinal muscular atrophy patients with hybrid SMN gene. Niba ETE, Nishio H, Wijaya YOS, Lai PS, Tozawa T, Chiyonobu T, Yamadera M, Okamoto K, Awano H, Takeshima Y, Saito T, Shinohara M. Brain Dev. 2021 Feb;43(2):294-302. doi: 10.1016/j.braindev.2020.09.005. Epub 2020 Oct 6. PMID: 33036822
  4. Empagliflozin ameliorates endothelial dysfunction and suppresses atherogenesis in diabetic apolipoprotein E-deficient mice. Ganbaatar B, Fukuda D, Shinohara M, Yagi S, Kusunose K, Yamada H, Soeki T, Hirata KI, Sata M. Eur J Pharmacol. 2020 Feb 27;875:173040. doi: 10.1016/j.ejphar.2020.173040. [Epub ahead of print] PMID: 32114052
  5. Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice. Kimura I, Miyamoto J, Ohue-Kitano R, Watanabe K, Yamada T, Onuki M, Aoki R, Isobe Y, Kashihara D, Inoue D, Inaba A, Takamura Y, Taira S, Kumaki S, Watanabe M, Ito M, Nakagawa F, Irie J, Kakuta H, Shinohara M, Iwatsuki K, Tsujimoto G, Ohno H, Arita M, Itoh H, Hase K. Science. 2020 Feb 28;367(6481). pii: eaaw8429. doi: 10.1126/science.aaw8429. PMID: 32108090
  6. Association of cholesterol uptake capacity, a novel indicator for HDL functionality, and coronary plaque properties: An optical coherence tomography-based observational study. Oshita T, Toh R, Nagano Y, Kuroda K, Nagasawa Y, Harada A, Murakami K, Kiriyama M, Yoshikawa K, Miwa K, Kubo T, Iino T, Nagao M, Irino Y, Hara T, Shinohara M, Otake H, Shinke T, Nakajima K, Ishida T, Hirata KI. Clin Chim Acta. 2020 Apr;503:136-144. doi: 10.1016/j.cca.2020.01.001. Epub 2020 Jan 21. PMID: 31972150
  7. Recombinant human thrombomodulin attenuated sepsis severity in a non-surgical preterm mouse model. Ashina M, Fujioka K, Nishida K, Okubo S, Ikuta T, Shinohara M, Iijima K. Sci Rep. 2020 Jan 15;10(1):333. doi: 10.1038/s41598-019-57265-2. PMID: 31941991

2019年

  1. Roles of Toll-like receptor 2/4, monoacylglycerol lipase, and cyclooxygenase in social defeat stress-induced prostaglandin E2 synthesis in the brain and their behavioral relevance. Nie X, Kitaoka S, Shinohara M, Kakizuka A, Narumiya S, Furuyashiki T. Sci Rep. 2019 Nov 26;9(1):17548. doi: 10.1038/s41598-019-54082-5. PMID: 31772309
  2. Serum elaidic acid concentration and risk of dementia: The Hisayama Study. Honda T, Ohara T, Shinohara M, Hata J, Toh R, Yoshida D, Shibata M, Ishida T, Hirakawa Y, Irino Y, Sakata S, Uchida K, Kitazono T, Kanba S, Hirata KI, Ninomiya T. Neurology. 2019 Nov 26;93(22):e2053-e2064. doi: 10.1212/WNL.0000000000008464. Epub 2019 Oct 23. PMID: 31645469
  3. Serum concentration of full-length- and carboxy-terminal fragments of endothelial lipase predicts future cardiovascular risks in patients with coronary artery disease. Nagao M, Miyashita K, Mori K, Irino Y, Toh R, Hara T, Hirata KI, Shinohara M, Nakajima K, Ishida T. J Clin Lipidol. 2019 Jul 29. pii: S1933-2874(19)30239-9. doi: 10.1016/j.jacl.2019.07.007. [Epub ahead of print]
  4. Change in brain plasmalogen composition by exposure to prenatal undernutrition leads to behavioral impairment of rats. Hino K, Kaneko S, Harasawa T, Kimura T, Takei S, Shinohara M, Yamazaki F, Morita SY, Sato S, Kubo Y, Kono T, Setou M, Yoshioka M, Fujino J, Sugihara H, Kojima H, Yamada N, Udagawa J. J Neurosci. 2019 Aug 7. pii: 2721-18. doi: 10.1523/JNEUROSCI.2721-18.2019. [Epub ahead of print] PMID: 31391260
  5. Effect of Rosuvastatin and Eicosapentaenoic Acid on Neoatherosclerosis: The LINK-IT Trial. Kuroda K, Otake H, Shinohara M, Kuroda M, Tsuda S, Toba T, Nagano Y, Toh R, Ishida T, Shinke T, Hirata KI. EuroIntervention. 2019 Jul 23. pii: EIJ-D-18-01073. doi: 10.4244/EIJ-D-18-01073. [Epub ahead of print] PMID: 31334703
  6. Identification of novel serum markers for the progression of coronary atherosclerosis in WHHLMI rabbits, an animal model of familial hypercholesterolemia. Shiomi M, Takeda H, Irino Y, Kimura N, Yamada S, Kuniyoshi N, Kikumori A, Koike Y, Koike T, Yoshida M, Izumi Y, Shinohara M, Bamba T, Ishida T. Atherosclerosis. 2019 Feb 28;284:18-23. doi: 10.1016/j.atherosclerosis.2019.02.020. [Epub ahead of print] PMID: 30870703
  7. Elevated Serum Elaidic Acid Predicts Risk of Repeat Revascularization After Percutaneous Coronary Intervention in Japan. Oshita T, Toh R, Shinohara M, Mori K, Irino Y, Nagao M, Hara T, Otake H, Ishida T, Hirata KI. Circ J. 2019 Mar 13. doi: 10.1253/circj.CJ-18-1175. [Epub ahead of print] PMID: 30867359

2018年

  1. Gut Microbiome and Plasma Microbiome-Related Metabolites in Patients With Decompensated and Compensated Heart Failure. Hayashi T, Yamashita T, Watanabe H, Kami K, Yoshida N, Tabata T, Emoto T, Sasaki N, Mizoguchi T, Irino Y, Toh R, Shinohara M, Okada Y, Ogawa W, Yamada T, Hirata KI. Circ J. 2018 Dec 25;83(1):182-192. doi: 10.1253/circj.CJ-18-0468. Epub 2018 Nov 29. PMID: 30487369
  2. Comparative metabolomics of Japanese Black cattle beef and other meats using gas chromatography-mass spectrometry. Ueda S, Iwamoto E, Kato Y, Shinohara M, Shirai Y, Yamanoue M. Biosci Biotechnol Biochem. 2018 Oct 18:1-11. doi: 10.1080/09168451.2018.1528139. [Epub ahead of print] PMID: 30336733t.
  3. Modulation of lipid mediator profile may contribute to amelioration of chronic inflammation in adipose tissue of obese mice by pioglitazone. Okada K, Hosooka T, Shinohara M, Ogawa W. Biochem Biophys Res Commun. 2018 Oct 20;505(1):29-35. doi: 10.1016/j.bbrc.2018.09.081. Epub 2018 Sep 17. PMID: 30236987
  4. Intron-retained transcripts of the spinal muscular atrophy genes, SMN1 and SMN2. Harahap NIF, Niba ETE, Ar Rochmah M, Wijaya YOS, Saito T, Saito K, Awano H, Morioka I, Iijima K, Lai PS, Matsuo M, Nishio H, Shinohara M. Brain Dev. 2018 Sep;40(8):670-677. doi: 10.1016/j.braindev.2018.03.001. Epub 2018 Mar 23. PMID: 29580671
  5. Pentose phosphate pathway activation via HSP27 phosphorylation by ATM kinase: A putative endogenous antioxidant defense mechanism during cerebral ischemia-reperfusion. Yamamoto Y, Hosoda K, Imahori T, Tanaka J, Matsuo K, Nakai T, Irino Y, Shinohara M, Sato N, Sasayama T, Tanaka K, Nagashima H, Kohta M, Kohmura E. Brain Res. 2018 May 15;1687:82-94. doi: 10.1016/j.brainres.2018.03.001. Epub 2018 Mar 3. PMID: 29510140

2017年

  1. SMA Diagnosis: Detection of SMN1 Deletion with Real-Time mCOP-PCR System Using Fresh Blood DNA. Niba ETE, Ar Rochmah M, Harahap NIF, Awano H, Morioka I, Iijima K, Saito T, Saito K, Takeuchi A, Lai PS, Bouike Y, Nishio H, Shinohara M. Kobe J Med Sci. 2017 Dec 18;63(3):E80-E83. PMID: 29434179
  2. Gender Effects on the Clinical Phenotype in Japanese Patients with Spinal Muscular Atrophy. Ar Rochmah M, Shima A, Harahap NIF, Niba ETE, Morisada N, Yanagisawa S, Saito T, Kaneko K, Saito K, Morioka I, Iijima K, Lai PS, Bouike Y, Nishio H, Shinohara M. Kobe J Med Sci. 2017 Oct 16;63(2):E41-E44. PMID: 29434173
  3. New, Improved Version of the mCOP-PCR Screening System for Detection of Spinal Muscular Atrophy Gene (SMN1) Deletion. Shinohara M, Ar Rochmah M, Nakanishi K, Harahap NIF, Niba ETE, Saito T, Saito K, Takeuchi A, Bouike Y, Nishio H. Kobe J Med Sci. 2017 Sep 7;63(2):E37-E40. PMID: 29434172
  4. Spinal muscular atrophy carriers with two SMN1 copies. Ar Rochmah M, Awano H, Awaya T, Harahap NIF, Morisada N, Bouike Y, Saito T, Kubo Y, Saito K, Lai PS, Morioka I, Iijima K, Nishio H, Shinohara M. Brain Dev. 2017 Jul 1. pii: S0387-7604(17)30171-7. doi: 10.1016/j.braindev.2017.06.002. [Epub ahead of print] PMID: 28676237
  5. DMD transcripts in CRL-2061 rhabdomyosarcoma cells show high levels of intron retention by intron-specific PCR amplification. Niba ETE, Yamanaka R, Rani AQM, Awano H, Matsumoto M, Nishio H, Matsuo M. Cancer Cell Int. 2017 May 23;17:58. doi: 10.1186/s12935-017-0428-4. eCollection 2017. PMID: 28546788
  6. Genetic screening of spinal muscular atrophy using a real-time modified COP-PCR technique with dried blood-spot DNA. Ar Rochmah M, Harahap NIF, Niba ETE, Nakanishi K, Awano H, Morioka I, Iijima K, Saito T, Saito K, Lai PS, Takeshima Y, Takeuchi A, Bouike Y, Okamoto M, Nishio H, Shinohara M. Brain Dev. 2017 May 15. pii: S0387-7604(17)30134-1. doi: 10.1016/j.braindev.2017.04.015. [Epub ahead of print] PMID: 28522225
  7. SMA mutations in SMN Tudor and C-terminal domains destabilize the protein. Takarada T, Ar Rochmah M, Harahap NIF, Shinohara M, Saito T, Saito K, Lai PS, Bouike Y, Takeshima Y, Awano H, Morioka I, Iijima K, Nishio H, Takeuchi A. Brain Dev. 2017 Aug;39(7):606-612. doi: 10.1016/j.braindev.2017.03.002. Epub 2017 Mar 31. PMID: 28366534
  8. Cryptic splice activation but not exon skipping is observed in minigene assays of dystrophin c.9361+1G>A mutation identified by NGS. Niba ETE, Nishida A, Tran VK, Vu DC, Matsumoto M, Awano H, Lee T, Takeshima Y, Nishio H, Matsuo M. J Hum Genet. 2017 Apr;62(5):531-537. doi: 10.1038/jhg.2016.162. Epub 2017 Jan 19. PMID: 28100912
  9. Novel mechanism of regulation of the 5-lipoxygenase/leukotriene B4 pathway by high-density lipoprotein in macrophages. Tsuda S, Shinohara M, Oshita T, Nagao M, Tanaka N, Mori T, Hara T, Irino Y, Toh R, Ishida T, Hirata KI. Sci Rep. 2017 Oct 11;7(1):12989. doi: 10.1038/s41598-017-13154-0. PMID: 29021582
  10. High-density lipoprotein protects cardiomyocytes from oxidative stress via the PI3K/mTOR signaling pathway. Nagao M, Toh R, Irino Y, Nakajima H, Oshita T, Tsuda S, Hara T, Shinohara M, Ishida T, Hirata KI. FEBS Open Bio. 2017 Aug 14;7(9):1402-1409. doi: 10.1002/2211-5463.12279. eCollection 2017 Sep. PMID: 28904868
  11. Targeted Disruption of JCAD (Junctional Protein Associated With Coronary Artery Disease)/KIAA1462, a Coronary Artery Disease-Associated Gene Product, Inhibits Angiogenic Processes In Vitro and In Vivo. Hara T, Monguchi T, Iwamoto N, Akashi M, Mori K, Oshita T, Okano M, Toh R, Irino Y, Shinohara M, Yamashita Y, Shioi G, Furuse M, Ishida T, Hirata KI. Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1667-1673. doi: 10.1161/ATVBAHA.117.309721. Epub 2017 Jul 13. PMID: 28705794
  12. Eicosapentaenoic Acid-Enriched High-Density Lipoproteins Exhibit Anti-Atherogenic Properties. Tanaka N, Irino Y, Shinohara M, Tsuda S, Mori T, Nagao M, Oshita T, Mori K, Hara T, Toh R, Ishida T, Hirata KI. Circ J. 2017 Jun 23. doi: 10.1253/circj.CJ-17-0294. [Epub ahead of print] PMID: 28652532
  13. Association between Serum Elaidic acid Concentration and Insulin Resistance in Two Japanese Cohorts with Different Lifestyles. Itcho K, Yoshii Y, Ohno H, Oki K, Shinohara M, Irino Y, Toh R, Ishida T, Hirata KI, Yoneda M. J Atheroscler Thromb. 2017 May 9. doi: 10.5551/jat.39164. [Epub ahead of print] PMID: 28484112
  14. Combined metabolic and transcriptional profiling identifies pentose phosphate pathway activation by HSP27 phosphorylation during cerebral ischemia. Imahori T, Hosoda K, Nakai T, Yamamoto Y, Irino Y, Shinohara M, Sato N, Sasayama T, Tanaka K, Nagashima H, Kohta M, Kohmura E. Neuroscience. 2017 May 4;349:1-16. doi: 10.1016/j.neuroscience.2017.02.036. Epub 2017 Mar 6. PMID: 28257891
  15. Excessive intake of trans fatty acid accelerates atherosclerosis through promoting inflammation and oxidative stress in a mouse model of hyperlipidemia. Monguchi T, Hara T, Hasokawa M, Nakajima H, Mori K, Toh R, Irino Y, Ishida T, Hirata KI, Shinohara M. J Cardiol. 2017 Aug;70(2):121-127. doi: 10.1016/j.jjcc.2016.12.012. Epub 2017 Feb 21. PMID: 28254384
  16. NLRP3 Inflammasome Deficiency Protects Against Microbial Sepsis via Increased Lipoxin B4 Synthesis. Lee S, Nakahira K, Dalli J, Siempos II, Norris PC, Colas RA, Moon JS, Shinohara M, Hisata S, Howrylak JA, Suh GY, Ryter SW, Serhan CN, Choi AM. Am J Respir Crit Care Med. 2017 Feb 28. doi: 10.1164/rccm.201604-0892OC. [Epub ahead of print] PMID: 28245134
  17. G-CSF-induced sympathetic tone provokes fever and primes antimobilizing functions of neutrophils via PGE2. Kawano Y, Fukui C, Shinohara M, Wakahashi K, Ishii S, Suzuki T, Sato M, Asada N, Kawano H, Minagawa K, Sada A, Furuyashiki T, Uematsu S, Akira S, Uede T, Narumiya S, Matsui T, Katayama Y. Blood. 2017 Feb 2;129(5):587-597. doi: 10.1182/blood-2016-07-725754. Epub 2016 Nov 8. PMID: 27827823
  18. Enhanced Impact of Cholesterol Absorption Marker on New Atherosclerotic Lesion Progression After Coronary Intervention During Statin Therapy. Mori K, Ishida T, Tsuda S, Oshita T, Shinohara M, Hara T, Irino Y, Toh R, Hirata KI. J Atheroscler Thromb. 2017 Feb 1;24(2):123-132. doi: 10.5551/jat.32615. Epub 2016 Aug 4. PMID: 27487947

2016

  1. Alternative splicing of a cryptic exon embedded in intron 6 of SMN1 and SMN2. Yoshimoto S, Harahap NI, Hamamura Y, Ar Rochmah M, Shima A, Morisada N, Shinohara M, Saito T, Saito K, Lai PS, Matsuo M, Awano H, Morioka I, Iijima K, Nishio H. Hum Genome Var. 2016 Dec 1;3:16040. eCollection 2016. PMID: 27917293
  2. Early detection of tumor relapse/regrowth by consecutive minimal residual disease monitoring in high-risk neuroblastoma patients. Hirase S, Saitoh A, Hartomo TB, Kozaki A, Yanai T, Hasegawa D, Kawasaki K, Kosaka Y, Matsuo M, Yamamoto N, Mori T, Hayakawa A, Iijima K, Nishio H, Nishimura N. Oncol Lett. 2016 Aug;12(2):1119-1123. Epub 2016 Jun 7. PMID: 27446404
  3. Fluorescent protein-based detection of unconjugated bilirubin in newborn serum. Iwatani S, Nakamura H, Kurokawa D, Yamana K, Nishida K, Fukushima S, Koda T, Nishimura N, Nishio H, Iijima K, Miyawaki A, Morioka I. Sci Rep. 2016 Jun 21;6:28489. doi: 10.1038/srep28489. PMID: 27324682
  4. Telomeric Region of the Spinal Muscular Atrophy Locus Is Susceptible to Structural Variations. Noguchi Y, Onishi A, Nakamachi Y, Hayashi N, Harahap NI, Rochmah MA, Shima A, Yanagisawa S, Morisada N, Nakagawa T, Iijima K, Kasagi S, Saegusa J, Kawano S, Shinohara M, Tairaku S, Saito T, Kubo Y, Saito K, Nishio H. Pediatr Neurol. 2016 May;58:83-9. doi: 10.1016/j.pediatrneurol.2016.01.019. Epub 2016 Jan 30. PMID: 27268759
  5. HEK293 cells express dystrophin Dp71 with nucleus-specific localization of Dp71ab. Nishida A, Yasuno S, Takeuchi A, Awano H, Lee T, Niba ET, Fujimoto T, Itoh K, Takeshima Y, Nishio H, Matsuo M. Histochem Cell Biol. 2016 Sep;146(3):301-9. doi: 10.1007/s00418-016-1439-2. Epub 2016 Apr 25. PMID: 27109495
  6. Rare renal ciliopathies in non-consanguineous families that were identified by targeted resequencing. Yamamura T, Morisada N, Nozu K, Minamikawa S, Ishimori S, Toyoshima D, Ninchoji T, Yasui M, Taniguchi-Ikeda M, Morioka I, Nakanishi K, Nishio H, Iijima K. Clin Exp Nephrol. 2017 Feb;21(1):136-142. doi: 10.1007/s10157-016-1256-x. Epub 2016 Mar 11. PMID: 26968886
  7. Next-generation sequencing discloses a nonsense mutation in the dystrophin gene from long preserved dried umbilical cord and low-level somatic mosaicism in the proband mother. Taniguchi-Ikeda M, Takeshima Y, Lee T, Nishiyama M, Awano H, Yagi M, Unzaki A, Nozu K, Nishio H, Matsuo M, Kurahashi H, Toda T, Morioka I, Iijima K. J Hum Genet. 2016 Apr;61(4):351-5. doi: 10.1038/jhg.2015.157. Epub 2016 Jan 7. PMID: 26740235
  8. 2-Aminobutyric acid modulates glutathione homeostasis in the myocardium. Irino Y, Toh R, Nagao M, Mori T, Honjo T, Shinohara M, Tsuda S, Nakajima H, Satomi-Kobayashi S, Shinke T, Tanaka H, Ishida T, Miyata O, Hirata KI. Sci Rep. 2016 Nov 9;6:36749. doi: 10.1038/srep36749. PMID: 27827456
  9. Promotion of Intestinal Epithelial Cell Turnover by Commensal Bacteria: Role of Short-Chain Fatty Acids. Park JH, Kotani T, Konno T, Setiawan J, Kitamura Y, Imada S, Usui Y, Hatano N, Shinohara M, Saito Y, Murata Y, Matozaki T. PLoS One. 2016 May 27;11(5):e0156334. doi: 10.1371/journal.pone.0156334. eCollection 2016. PMID: 27232601
  10. Novel Endogenous Proresolving Molecules:Essential Fatty Acid-Derived and Gaseous Mediators in the Resolution of Inflammation. Shinohara M, Serhan CN. J Atheroscler Thromb. 2016 Jun 1;23(6):655-64. doi: 10.5551/jat.33928. Epub 2016 Apr 6. Review. PMID: 27052783