臨床研究

• 肺癌手術によるPHRの長期的推移に関する探索的前向き研究（JCOG2217A1）
• 肺縮小手術におけるステイプルライン補強材使用に関する多施設ランダム化比較試験
• 「肺縮小手術におけるステイプルライン補強材使用に関する多施設ランダム化比較試験（25C001）」の附随研究　手術用自動縫合器のICチップデータから得られる操作解析と術中エアリークの検討
• SUV Harmonizationを用いた腫瘍最大径3cm以下かつ充実成分優位な臨床病期IA2-IA3期非小細胞肺癌における画像的Less invasive cancerの定義に関する多施設前向き観察研究
• 病理病期IA2-IIA期EGFR遺伝子変異陽性非小細胞肺癌における術後補助療法の実態を調査する多施設共同前向き観察研究
• JACTOP-02: ALK陽性非小細胞肺癌に対するAlectinib術後補助療法の300mg BIDの有効性を検証する単群第III相試験
• JACTOP-01: EGFR遺伝子変異陽性病理病期II-III期非扁平上皮非小細胞肺癌完全切除例に対するOsimertinib術後補助療法最適化に関するランダム化比較第III相試験（OASIS）
• 手術教育用AIシステムを用いた無名静脈認知に関する研究
• JCOG2501：肺野中枢小型充実成分優位非小細胞肺癌に対する肺葉切除と区域切除のランダム化比較試験
• 早期・局所進行期KRAS遺伝子変異陽性 非小細胞肺癌のレジストリ研究 （REGORAS）術中洗浄液を用いた肺がん切除断端の分子学的評価法の開発と局所再発予測への応用の検討
• hinotoriロボット支援肺切除術における多孔式（5ポート）とD-RATS（2ポート）の術後疼痛短期成績の比較：前向き観察研究
• 臨床病期I/II期非小細胞肺癌に対する選択的リンパ節郭清の治療的意義に関するランダム化比較試験
• JCOG1708:特発性肺線維症合併臨床病期I期非小細胞肺癌に対する肺縮小手術に関するランダム化比較第III相試験
• 肺葉切除高リスク臨床病期IA期非小細胞肺癌に対する区域切除と楔状切除のランダム化比較試験
• JCOG1916：病理学的N2非小細胞肺癌に対する術後放射線治療に関するランダム化比較第III相試験
• 再発高リスク臨床病期I期非小細胞肺がんを対象とした　術前Nivolumab施行例に関する観察研究
• 胸部薄切所見に基づく早期肺癌に対する経過観察の単群検証的試験
• JCOG-バイオバンク・ジャパン連携バイオバンク
• JANP studyにおいて集積された臨床検体の保存および医学研究への利用（包括的同意）
• 原発性肺癌における胸膜下リンパ流の同定についての探索的研究
• JCOG2012 :病理病期 II-IIIA 期非小細胞肺癌に対する術後サーベイランスに関するランダム化比較試験
• JCOG2109 : 80 歳以上の高齢者肺野末梢小型非小細胞肺癌における区域切除 vs. 楔状切除のランダム化比較試験
• WJOG16923L：臨床病期IA3期の肺野末梢充実型非小細胞肺癌に対する肺葉切除と区域切除のランダム化比較第Ⅲ相試験
• JCOG2217：胸部薄切CT上すりガラス成分を伴う充実成分優位な非小細胞肺癌（＞2-3cm）に対する肺葉切除と区域切除のランダム化比較試験
• 非小細胞肺癌手術例における全ゲノム解析を用いたバイオマーカー研究
• 縦隔リンパ節転移を有するIIIA期ヒト上皮成長因子受容体（EGFR）遺伝子変異陽性非小細胞肺癌に対するエルロチニブによる術前導入療法後の外科的切除の第II相試験
• JCOG1807C：肺尖部胸壁浸潤癌に対する化学放射線療法後の術前後デュルバルマブもしくはデュルバルマブ維持療法を併用した集学的治療に関する単群検証的試験
• JCOG2103: 画像上診断困難な胸膜播種を有する臨床病期IVA期（cT1-2bN0-1M1a）非小細胞肺癌に対する原発巣切除追加の治療的意義を検証するランダム化比較第III相試験
• 原発性肺癌における胸膜下リンパ流の同定についての探索的研究
• JCOG2108: 非小細胞肺癌術後オリゴ再発に対する全身治療後の維持療法と局所治療を比較するランダム化比較第III相試験
• 切除可能な臨床病期 II-III 期非小細胞肺癌に対する術前療法後手術と手術先行療法に関するランダム化比較第 III 相試験
• LC-SCRUM-Advantage/MRD：肺癌における周術期個別化医療の確立を目指した遺伝子スクリーニングと微小残存病変のモニタリングのための多施設共同前向き観察研究
• 肺・縦隔腫瘍を対象とした、研究目的での手術検体保管

オプトアウト

• 胸壁浸潤(肺尖部胸壁浸潤癌を除いた)を伴う非小細胞肺癌患者に対する治療の実態に関する多施設共同後向き観察研究
• 神経内分泌肺癌切除例における疫学ならびに再発・予後を調査する多施設共同後ろ向き観察研究（CReGYT-06）
• 原発性肺癌に対する免疫療法後サルベージ手術の有効性・安全性を検討する多施設後向き研究観察研究（CReGYT-05）
• 手術教育用AIシステムを用いた無名静脈認知に関する研究
• 2017年に外科治療を施行された肺癌症例のデータベース研究（肺癌登録合同委員会第10次事業）
• 2021年に外科治療を施行された肺癌症例のデータベース研究 肺癌登録合同委員会 第11次事業
• RNAシークエンスを用いた縦隔肉腫における遺伝子発現解析
• 胸腺カルチノイドに対する至適治療とその予後について検討する多施設後向き観察研究
• 原発性肺癌に対する腫瘍の局在性と術後予後の相関を調査する後ろ向き観察研究
• 切除肺combined神経内分泌癌（SCLC-AD）のRNA発現解析による腫瘍構造と治療標的の解明
• 肺癌患者の術式選択と他病死リスクに関する多施設共同後ろ向き観察研究－肺切除と他病死リスク研究－
• 肺腺癌手術症例におけるALK融合遺伝子に関する疫学ならびに再発・予後を調査する多機関共同後ろ向き観察研究(CReGYT-03 ALK study)
• 非小細胞肺癌における術前化学免疫療法の安全性・有効性に関する多施設共同後ろ向き観察研究 (CReGYT-04)
• 非小細胞肺癌に対する縮小手術後症例における再発及び長期予後に関する多施設共同後ろ向き観察研究

実績

英文

• Tane S, Nishikubo M, Manabe T, Watanabe T, Nomura K, Hamada A, Takamori S,
  Katsumata S, Shimizu N, Kojima H, Takamori S, Muto S, Abe M, Yoshikawa M, Suzuki J,
  Toda M, Okada S, Kano S, Ohde Y, Maniwa Y. Efficacy and Safety of Salvage Surgery
  After Immunotherapy in Non-small Cell Lung Cancer: A Multi-institutional Retrospective
  Study. Ann Surg Oncol. 2026 Jun;33(6):5377-5386.
• Tane S, Maniwa Y. ASO Author Reflections: Salvage Surgery in the Immunotherapy Era: A New Paradigm for Advanced Non-Small Cell Lung Cancer.
  Ann Surg Oncol. 2026 Jun;33(6):5419-5420.
• Toda M, Takada K, Nomura K, Kosai K, Hayasaka K, Watanabe T, Takamori S, Hamada A,
  Suda K, Ohara S, Ito M, Oiki H, Fukami T, Muto S, Katsumata S, Konno H, Toyoda T, Endo M, Takamori S, Nakatsuka M, Tenpaku H, Takegahara K, Matsubara T, Kinoshita F,
  Akamine T, Nakamura R, Mizuno K, Nakagawa K, Kaneda S, Okada S, Notsuda H,
  Sakane T, Shinohara S, Abe M, Haratake N, Tane S, Hanawa R, Ito A, Namba K,
  Kawaguchi T, Minegishi K, Kurihara N, Iguchi T, Aokage K, Tsuboi M, Iwata T, Soh J,
  Shimokawa M, Ohde Y. Lack of impact of antibiotics and proton pump inhibitors on the
  efficacy of preoperative chemoimmunotherapy in locally advanced non-small cell lung
  cancer: A multicenter retrospective study.
  Lung Cancer. 2026 Apr;214:109344.
• Takamochi K, Suzuki K, Tsuboi M, Niho S, Ishikura S, Kobayashi S, Oyamada S,
  Yamaguchi T, Suzuki H, Ito H, Okumura N, Tanaka F, Saji H, Koike T, Horio H, Endo M, Fujiwara T, Ikeda N, Tanaka T, Iwata H, Haruki T, Suzuki H, Maniwa Y, Shiono S, Okada M. Induction chemotherapy plus bevacizumab or radiotherapy in N2 non-squamous non-small cell lung cancer: 5-year results of a randomized phase 2 trial.
  JTCVS Open. 2026 Apr;30:101607.
• Mitsui S, Jimbo N, Ogawa H, Tane S, Hokka D, Kitamura Y, Maniwa Y, Itoh T. POU2F3
  expression in lung squamous cell carcinoma: transcriptomic and immunohistochemical
  profiling with prognosis. Jpn J Clin Oncol. 2026;00(00):1-13.
• Tane S, Hokka D, Izawa R, Ogawa H, Kitamura Y, Uchino K, Maniwa Y. Dual-port robot-
  assisted thoracic surgery using hinotori™ surgical system.
  Gen Thorac Cardiovasc Surg. 2026 in press.
• Tane S, Nomura K, Watanabe T, Takamori S, Ohara S, Oiki H, Katsumata S,Takamori S, Nakatsuka M, Tenpaku H, Nakamura R, Notsuda H, Namba K, Minegishi K, Kitamura Y, Abe M, Takegahara K, Konno H, Mizuno K, Toyoda T, Satoshi Muto S, Toda M, Endo M, Maniwa Y, Soh J, Ohde Y. Preoperative Predictors of Surgical Complexity After Neoadjuvant Immunochemotherapy in non-small-cell lung cancer.
  Ann Surg Oncol. 2026 in press.
• Takamori S, Tane S, Nishikubo M, Watanabe T, Nomura K, Hamada A, Takamori S,
  Katsumata S, Shiono S. Clinical predictors of pathological response after immunotherapy insalvage surgery for non-small cell lung cancer: a supplementary analysis of the CReGYT-05 immune checkpoint inhibitor-salvage study.
  Gen Thorac Cardiovasc Surg. 2026 in press.
• Koga T, Ogawa H, Radulovich N, Pham NA, Li Q, Nakajima T, Djan M, Li M, Wang Y,
  Hinokuma H, Fujibayashi Y, Hiraishi Y, Sata Y, Kitazawa S, Suzuki M, Aoi T, Maniwa Y,Tsao MS, Yasufuku K. Endobronchial ultrasound-guided biopsy-derived lung cancermodels: a platform for precision therapy. J Thorac Oncol. 2026 Apr 27:103893.
• Tane S, Shimizu N, Jimbo N, Takanashi M, Doi T, Ogawa H, Hokka D, Kitamura Y,
  Shimomura Y, Nishio W, Maniwa Y. Impact of pathologically confirmed inner lung tumors
  on nodal upstaging and feasibility of segmentectomy versus lobectomy.
  JTCVS Open. 2025 Dec 27;29:101575.
• Kohama T, Sakamoto T, Tanahashi M, Maniwa Y. Larger polyglycolic acid sheet pleural
  covering to reduce postoperative recurrence of primary spontaneous pneumothorax. J
  Thorac Dis. 2025 Jul 31;17(7):4576-4586.
• Nomura K, Watanabe T, Takamori S, Hamada A, Suda K, Ito M, Ohara S, Oiki H, Fukami
  T, Muto S, Katsumata S, Konno H, Hayasaka K, Toyoda T, Endo M, Takamori S,
  Nakatsuka M, Tenpaku H, Takegahara K, Matsubara T, Kinoshita F, Akamine T, Nakamura
  R, Mizuno K, Nakagawa K, Kaneda S, Okada S, Kosai K, Notsuda H, Sakane T, ShinoharaS, Abe M, Haratake N, Tane S, Hanawa R, Tarukawa T, Namba K, Toda M, Kawaguchi T,
  Takada K, Minegishi K, Kurihara N, Iguchi T, Aokage K, Tsutani Y, Tsuboi M, Soh J,
  Shimokawa M, Ohde Y. Safety Profile of Neoadjuvant Chemoimmunotherapy With
  Nivolumab for Patients With Resectable Non-Small Cell Lung Cancer in the Real World
  (CReGYT-04 Neo-Venus).
  Ann Thorac Surg. 2025 Oct 30:S0003-4975(25)01059-8.
• Tane S. The Future Direction of Artificial-Intelligence-Aided Thoracic Surgery.
  Ann Surg Oncol. 2025 Sep;32(9):6203-6204.
• Fujibayashi Y, Takata M, Tsubota N, Maniwa Y. Segmentectomy versus lobectomy: does
  FEV1.0 change accurately reflect the postoperative cardiopulmonary function Gen Thorac Cardiovasc Surg. 2025;73:96-101. doi:10.1007/s11748-024-02052-8.
• Waseda R, Yamamoto H, Shintani Y, Sato T, Suzuki K, Maniwa Y, Sato Y, Yoshino I,
  Chida M. Preoperative risk-factors for secondary spontaneous pneumothorax surgery in Japan: a nationwide database study. Surg Today. 2025 Mar;55(3):393-404.
• Koga K, Tane S, Tanaka Y, Takanashi M, Izawa R, Ogawa H, Hokka D, Kitamura Y,
  Maniwa Y. A Novel Wound Protector With Honeycomb Meshing for Thoracoscopic
  Surgery.
  Asian J Endosc Surg. 2025 Jan-Dec;18(1):e70150.
• Tane S, Izawa R, Ogawa H, Hokka D, Maniwa Y. Consoler and bedside surgeon fused
  uniportal robotic-assisted thoracoscopic surgery.
  J Chest Surg. 2025 May 29;58 Suppl 1:S82.
• Watanabe T, Sakane T, Fujino K, Handa Y, Iida T, Shinohara S, Hanawa R, Doi T, Ito A,Tanahashi M. Bronchopleural fistula: a multi-institutional analysis of the treatment outcomes and prognostic factors in the ESSG-01 study.
  Eur J Cardiothorac Surg. 2025 Jun 19;67(6):ezaf207.
• Watanabe T, Nomura K, Takamori S, Tane S, Ohara S, Oiki H, Katsumata S, Endo M,
  Takamori S, Nakatsuka M, Tenpaku H, Nakamura R, Notsuda H, Namba K, Minegishi K,
  Tanahashi M, Tsuboi M, Soh J, Shimokawa M, Ohde Y. Preoperative Immune-Related
  Adverse Events in Resectable NSCLC Treated With Neoadjuvant Nivolumab Plus
  Chemotherapy: A Multicenter Retrospective Analysis.
  JTO Clin Res Rep. 2025 Oct 30;7(1):100930.
• Izawa R, Tane S, Doi T, Ogawa H, Hokka D, Maniwa Y. Novel, noninvasive, extended
  reality-aided pulmonary tumor marking method for sublobar resection in minimally invasive surgery.
  JTCVS Tech. 2025 Jul 2;32:157-162.
• Mitsui S, Tanaka Y, Jimbo N, Ogawa H, Tane S, Hokka D, Okada K, Mitomo Y, Maniwa Y.
  Ribonucleic Acid Sequencing Analysis of Intimal Sarcoma of the Large Blood Vessels.
  Eur J Cardiothorac Surg. 2025 Aug 2;67(8):ezaf245.
• Mitsui S, Jimbo N, Tanaka Y, Ogawa H, Tane S, Hokka D, Maniwa Y. Clinical Impact of
  POU2F3 Expression in Surgically Resected Pulmonary High-Grade Neuroendocrine
  Carcinoma.
  Cureus. 2025 Apr 21;17(4):e82758.
• Nishikubo M, Tanaka Y, Tane S, Hokka D, Maniwa Y. Lobectomy Increases Postoperative
  Pulmonary Artery Enlargement to a Greater Extent than Segmentectomy.
  Ann Thorac Cardiovasc Surg. 2025;31(1):24-00083.
• Mitsui S, Tanaka Y, Nishikubo M, Doi T, Tane S, Hokka D, Imai T, Maniwa Y. Ninjin'yoeito
  improves respiratory symptoms after lung cancer surgery: a prospective randomized study.Surg Today. 2025 May;55(5):693-704.
• Watanabe T, Fujino K, Sakane T, Handa Y, Doi T, Kawatani N, Nakazawa S, Iida T,
  Hanawa R, Shinohara S, Ito A, Tanahashi M. Completion lobectomy following
  segmentectomy for malignant lung tumors: a multi-institutional study of surgical feasibility,oncologic outcomes, and diagnostic challenges (ESSG-02 study).
  Transl Lung Cancer Res.2025 Dec 31;14(12):5372-5382.
• Uno Y, Tane S, Tanaka Y, Takanashi M, Doi T, Ogawa H, Hokka D, Maniwa Y. Learning
  curve of consolers and bedside surgeons fused robotic-assisted thoracoscopic
  segmentectomy: insights from the initial 100 cases.
  Surg Today. 2025 Jun;55(6):823-829.
• Honda T, Tauchi S. Chest drainage outcomes by water seal versus low suction on digital
  drainage systems after lung resection: retrospective study.
  J Thorac Dis. 16(10):6644-6650, 2024.
• Tane S. The Crucial Value of Glutathione Peroxidase 2 to Understand the 'Two-Faced'
  Role of Reactive Oxygen Species in Lung Adenocarcinoma.
  Ann Surg Oncol. 2024 Aug;31(8):4849-4850.
• Jimbo N, Ohbayashi C, Takeda M, Fujii T, Mitsui S, Tsukamoto R, Tanaka Y, Itoh T,
  Maniwa Y.
  POU2F3-expressing small cell lung carcinoma and large cell neuroendocrine carcinoma
  show morphologic and phenotypic overlap. Am J Surg Pathol. 2024 Jan;48(1):4–15.
• Jimbo N, Ohbayashi C, Fujii T, Takeda M, Mitsui S, Tanaka Y, Itoh T, Maniwa Y. The
  expression of YAP1 and other transcription factors contributes to lineage plasticity in combined small cell lung carcinoma. J Pathol Clin Res. 2024 Sep;10:e70001.
• Ogawa H, Koga T, Pham NA, Bernards N, Gregor A, Sata Y, Kitazawa S, Hiraishi Y,
  Ishiwata T, Aragaki M, Yokote F, Effat A, Kazlovich K, Li Q, Hueniken K, Li M, Maniwa Y,Tsao MS, Yasufuku K. Clinical and pathological predictors of engraftment for patient-derived xenografts in lung adenocarcinoma. Lung Cancer. 2024 Aug;194:107863.
• Jimbo N, Ohbayashi C, Fujii T, Takeda M, Mitsui S, Tsukamoto R, Tanaka Y, Itoh T,
  Maniwa Y.
  Implication of cytoplasmic p53 expression in pulmonary neuroendocrine carcinoma using
  next-generation sequencing analysis. Histopathology. 2024;84(3):336–342.
• Mizuno T, Chen-Yoshikawa TF, Yoshino I, Okumura M, Ikeda N, Kuroda K, Maniwa Y,
  Kanzaki M, Suzuki M; Japanese Association for Research on the Thymus. Updated
  outcomes of surgical treatment for recurrent thymic tumour: a report from the Japanese
  nationwide database. Interdiscip Cardiovasc Thorac Surg. 2024 Jun 19;38(6):ivae064.
• Tane S, Okami J, Maniwa Y, Shintani Y, Ito H, Ohtsuka T, Toyooka S, Mori T, Watanabe
  SI, Chida M, Endo S, Nakanishi R, Kadokura M, Suzuki H, Miyaoka E, Yoshino I, Date H;
  Japanese Joint Committee of Lung Cancer Registry. Clinical outcomes of left upper
  segmentectomy vs. lobectomy for early non-small-cell lung cancer: a nationwide databasestudy in Japan.
  Surg Today. 2024 Oct;54(10):1162-1172.
• Okuma H, Saijo-Hamano Y, Yamada H, Sherif AA, Hashizaki E, Sakai N, Kato T, Imasaki
  T, Kikkawa S, Nitta E, Sasai M, Abe T, Sugihara F, Maniwa Y, Kosako H, Takei K, Standley
  DM, Yamamoto M, Nitta R. Structural basis of Irgb6 inactivation by Toxoplasma gondii
  through the phosphorylation of switch I. Genes Cells. 2024 Jan;29(1):17-38.
  Mitsui S, Tanaka Y, Nishikubo M, Doi T, Tane S, Hokka D, Mitomo Y, Maniwa Y. Safety
  and efficacy of new staple-line reinforcement in lung resection: a prospective study of 48 patients.
  Surg Today. 2024 Jul;54(7):779-786.
• Tanaka Y, Tane S, Doi T, Mitsui S, Nishikubo M, Hokka D, Maniwa Y. Factors affecting the
  short-term outcomes of robotic-assisted thoracoscopic surgery for lung cancer.
  Surg Today. 2024 Aug;54(8):874-881.
• Wang M, Zhang Y, Liu M, Wang Y, Niu X, Qiu D, Xi H, Zhou Y, Chang N, Xu T, Xing L,
  Yamauchi Y, Terra RM, Tane S, Moon MH, Yan X, Zhao F, Zhang J. Exploration of a novel
  prognostic model based on nomogram in non-small cell lung cancer patients with distant
  organ metastasis: implications for immunotherapy.
  Transl Lung Cancer Res. 2023 Oct 31;12(10):2040-2054.
• Tane S, Tanaka Y, Nishikubo M, Doi T, Hokka D, Maniwa Y. Console and bedside surgeon
  fused robot-assisted thoracic surgery.
  Gen Thorac Cardiovasc Surg. 2023 Dec;71(12):730-732.
• Mitsui S, Tanaka Y, Jimbo N, Doi T, Tane S, Hokka D, Maniwa Y. Programmed death
  ligand-1 expression and occult lymph node metastasis in non-small cell lung cancer.
  Thorac Cancer. 2023 Jun;14(18):1774-1781.
• Tane S, Nishioka Y, Tanaka Y, Uchino K, Nishio W, Maniwa Y. Uniportal left S1 + 2
  segmentectomy.
  Gen Thorac Cardiovasc Surg. 2023 Jul;71(7):432-435.
• Kuroda S, Tane S, Kitamura Y, Maniwa Y, Nishio W. The dynamic pulmonary functional
  change after thoracoscopic lower lobe segmentectomy.
  Asian Cardiovasc Thorac Ann. 2023 Mar;31(3):229-237.
• Kitazume M, Tane S, Shimizu N, Kitamura Y, Maniwa Y, Nishio W. Segmental volumetric
  analysis with ventilated or perfused area: Identify the intersegmental plane.
  Eur JCardiothorac Surg, 2022: 62(6): ezac537.
• Nishikubo M, Tane S, Kimura K, Shimizu N, Kitamura Y, Nishio W. Comparison ofoncological outcomes between trisegmentectomy and lobectomy for non-small cell lung
  cancer in the left upper division.
  J Thorac Dis, 2022: 14(12): 4614-4623.
• Tane S, Kitamura Y, Kimura K, Shimizu N, Matsumoto G, Uchino K, Nishio W.
  Segmentectomy versus lobectomy for inner-located small-sized early non-small-cell lung cancer.
  Interact CardioVasc Thorac Surg, 2022: 35(4): ivac218.
• Mitsui S, Tanaka Y , Doi T, Hokka D, Maniwa Y .
  Prognostic value of preoperative plasma fibrinogen levels in resected stage I non-small cell lung cancer.
  Thorac Cancer. 2022 May;13(10):1490–1495.
• Minami K, Jimbo N, Tanaka Y, Uchida T, Okamoto T, Shimizu N, Doi T, 　Hokka D, Itoh T, Maniwa Y. Fibrous bands associated with higher Masaoka stage and poor recurrence-free survival in patients with thymoma.
  Thorac Cancer. 12(3):349-356, 2021.
• Mitsui S, Tanaka Y, Kimura K, Jimbo N, Chihara N, Maniwa Y. Paraneoplastic Neuromyelitis Optica Spectrum Disorder Associated with Atypical Thymic Carcinoid: A Case Report.
  Ann Thorac Cardiovasc Surg. in press.
• Tanaka Y, Yamamoto H, Sato M, Toyooka S, Okada M, Endo S, Sato Y, Suzuki K, Maniwa Y, Fukuchi E, Miyata H, Chida M. Preoperative cumulative smoking dose on lung cancer surgery in a Japanese nationwide database.
  Ann Thorac Surg. 113(1):237-243, 2022.
• Uchida T, Tanaka Y, Kuroda S, Hokka D, Maniwa Y. Successful treatment of refractory empyema using dual sheet covering.
  Asian Cardiovasc Thorac Ann. in press.
• Hokka D, Tanaka Y, Shimizu N, Doi T, Maniwa Y. Oxidized Regenerated Cellulose Sheets in Postoperative Intrathoracic Adhesions.
  Ann Thorac Cardiovasc Surg. in press
• Shimizu N, Tanaka Y, Tachihara M, Maniwa Y. ROS1-rearranged lung cancer successfully resected after response to crizotinib: A case report
  Kobe J. Med. Sci., in press
• Mitsui S, Tauchi S, Tanaka Y, Tobe S. Pulmonary arteriovenous fistula ruptured in an adolescent girl 1 week after her mother's rupture: a report of a case.
  Gen Thorac Cardiovasc Surg. 69(1):130-132, 2021.
• Nishikubo M, Kin Y, Tane S, Nakamura K, Miyagi Y, Miura A, Nishio W, Senzaki H, Uchino K. Cellular cannibalism and consequent thrombocytopenia in a patient with bone marrow metastasis of malignant pleural mesothelioma: A case report.
  Mol Clin Oncol. 15(2):163, 2021.
• Mitsui S, Tauchi S, Uchida T, Ohnishi H, Shimokawa T, Tobe S. Low suction on digital drainage devices promptly improves post-operative air leaks following lung resection operations: a retrospective study.
  J Cardiothorac Surg. 2021 Apr 21;16(1):105.
• Mitsui S, Tauchi S.
  Tension pyopneumothorax.
  BMJ Case Rep. 14(3):e242197, 2021.
• Mitsui S, Tauchi S, Mizuki S, Tobe S.
  Extended-spectrum β-lactamase-producing Escherichia coli rib osteomyelitis with debridement and vacuum-assisted closure.
  BMJ Case Rep. 14(1):e238029, 2021.
• Jimbo N, Tateyama H, Komatsu M, Doi T, Tanaka Y, Maniwa Y, Itoh T.
  A case of type AB thymoma with atypical histological features: Is atypical type AB thymoma an acceptable variant of thymoma?
  Pathol Int. 71(4):272-274, 2021.
• Saito T, Ono R, Tanaka Y, Tatebayashi D, Okumura M, Makiura D, Inoue J, Fujikawa T, Kondo S, Inoue T, Maniwa Y, Sakai Y.
  The effect of home-based preoperative pulmonary rehabilitation before lung resection: a retrospective cohort study.
  Lung Cancer. in press
• Safety and Immunogenicity of the COVID-19 Vaccine BNT162b2 in Patients Undergoing Chemotherapy for Solid Cancer
  Journal of Infection and Chemotherapy. In press
• Nishikubo M, Jimbo N, Tanaka Y, Tachihara M, Itoh T, Maniwa Y. Sarcomatoid mesothelioma originating from mesothelioma in situ: are methylthioadenosine phosphorylase loss and CDKN2A homozygous deletion poor prognostic factors for preinvasive mesothelioma? Virchows Arch. 2022 Jan 19. doi: 10.1007/s00428-022-03281-z. Epub ahead of print. PMID: 35043235.
• Suguru Mitsui , Yugo Tanaka, Takefumi Doi, Daisuke Hokka, Yoshimasa Maniwa
  Prognostic value of preoperative plasma fibrinogen levels in resected stage I non-small cell lung cancer
  Thorac cancer 2022;13:1490-1495.
• Tane S, Kitazume M, Fujibayashi Y, Kuroda S, Kimura K, Kitamura Y, Takenaka D, Nishio W. The difference in postoperative pulmonary functional change between upper and lower thoracoscopic segmentectomy. Interact Cardiovasc Thorac Surg, 2022; 34(3): 408-415.
• Tane S, Kimura K, Shimizu N, Kitamura Y, Matsumoto G, Uchino K, Nishio W. Segmentectomy for inner location non-small-cell lung cancer: Is it feasible? Ann Thorac Surg, Article in press, 2022.　
• Fujibayashi Y, Tane S, Kitazume M, Kuroda S, Kimura K, Kitamura Y, Nishio W. Resected stage I anaplastic lymphoma kinase-positive lung adenocarcinoma has a negative impact on recurrence-free survival. Thoracic Cancer, 2022; 13(8): 1109-1116.
• Tane S, Ando Y, Matsumoto G, Ueda S, Uchino K. Basal segment deep wedge resection for lung cancer with pulmonary fibrosis. Gen Thorac Cardiovasc Surg. 2022; 70(4): 413-415.
• Minami K, Jimbo N, Tanaka Y, et al. Malignant mesothelioma in situ diagnosed by methylthioadenosine phosphorylase loss and homozygous deletion of CDKN2A: a case report. Virchows Arch. 2020;476(3):469-473.
• Kimura K, Ogawa H, Jimbo N, Hokka D, Tanaka Y, Maniwa Y. A case of leiomyosarcoma originating from a bronchogenic cyst: A case report. Mol Clin Oncol. 2020;12(3):244‐246.
• Jimbo N, Kawahara K, Tsukamoto R, et al. Malignant pleural mesothelioma showing intrapulmonary lepidic spread. Pathol Int. 2020;70(6):373-375.
• Minami K, Jimbo N, Tanaka Y, et al. Insulinoma-associated protein 1 is a prognostic biomarker in pulmonary high-grade neuroendocrine carcinoma. J Surg Oncol. 2020;122(2):243-253.
• Minami K, Tanaka Y, Ogawa H, et al. Neuroendocrine marker staining pattern categorization of small-sized pulmonary large cell neuroendocrine carcinoma. Thorac Cancer. 2019;10(11):2152‐2160.
• Ogawa H, Tanaka Y, Kitamura Y, et al. Efficacy of perioperative chemotherapy for pulmonary high-grade neuroendocrine carcinomas: a propensity score matching analysis. J Thorac Dis. 2019;11(4):1145‐1154.
• Shimizu N, Tanaka Y, Maniwa Y. Establishment of a safe thoracoscopic surgery. J Thorac Dis. 2019;11(Suppl 9):S1430‐S1431.
• Uchida T, Tanaka Y, Shimizu N, et al. Diaphragmatic plication for iatrogenic respiratory insufficiency after cardiothoracic surgery. J Thorac Dis. 2019;11(9):3704‐3711.
• Ogawa H, Tanaka Y, Tachihara M, et al. ROS1-rearranged high-PD-L1-expressing lung adenocarcinoma manifesting as mediastinal tumor: A case report. Oncol Lett. 2019;17(1):488‐491.
• Shimizu N, Tanaka Y, Demizu Y, Okimoto T, Maniwa Y. Surgery and Proton Beam Therapy for Mediastinal Extraskeletal Osteosarcoma. Ann Thorac Surg. 2019;108(5):e289‐e291.
• Tsuboshima K, Matoba Y, Wakahara T, Maniwa Y. Natural history of bulla neogenesis for primary spontaneous pneumothorax: a propensity score analysis. Gen Thorac Cardiovasc Surg. 2019;67(5):464‐469.
• Kimura K, Tanaka Y, Tauchi S, et al. Psf3 as a possible biomarker of postoperative chemotherapy for patients with early pulmonary adenocarcinoma. Thorac Cancer. 2019;10(12):2300‐2307.
• Tsuboshima K, Wakahara T, Matoba Y, Maniwa Y. Pleural Coating by 50% Glucose Solution Reduces Postoperative Recurrence of Spontaneous Pneumothorax. Ann Thorac Surg. 2018;106(1):184‐191.
• Shimizu N, Tanaka Y, Okamoto T, Doi T, Hokka D, Maniwa Y. How to prevent adverse events of vascular stapling in thoracic surgery: recommendations based on a clinical and experimental study. J Thorac Dis. 2018;10(12):6466‐6471.
• Saji T, Nishita M, Ogawa H, et al. Critical role of the Ror-family of receptor tyrosine kinases in invasion and proliferation of malignant pleural mesothelioma cells. Genes Cells. 2018;23(7):606‐613.
• Kishida Y, Seki S, Yoshikawa T, et al. Performance Comparison Between 18F-FDG PET/CT Plus Brain MRI and Conventional Staging Plus Brain MRI in Staging of Small Cell Lung Carcinoma. AJR Am J Roentgenol. 2018;211(1):185‐192.
• Ogawa H, Koyanagi-Aoi M, Otani K, Zen Y, Maniwa Y, Aoi T. Interleukin-6 blockade attenuates lung cancer tissue construction integrated by cancer stem cells. Sci Rep. 2017;7(1):12317. Published 2017 Sep 26.
• Tanaka Y, Hokka D, Ogawa H, Shimizu N, Inoue T, Tanaka H, Okita Y, Maniwa Y. Surgery for malignant lesions of the chest which extensively involved the mediastinum, lung, and heart. Gen Thorac Cardiovasc Surg. 2017;65:365-373.
• Tauchi S, Sakai Y, Fujimoto S, Ogawa H, Tane S, Hokka D, Tanaka Y, Nishio W, Yoshimura M, Yanagita E, Itoh T, Hayashi Y, Maniwa Y. Psf3 is a prognostic biomarker in lung adenocarcinoma: a larger trial using tissue microarrays of 864 consecutive resections. Eur J Cardiothorac Surg. 2016;50:758-764.
• Tanaka Y, Tane S, Hokka D, Ogawa H, Maniwa Y. The Use of Oxidized Regenerated Cellulose for Video-Assisted Thoracic Surgery. Ann Thorac Surg. 2016;101:786-8.
• Hokka D, Ogawa H, Tane S, Tanaka Y, Tauchi S, Maniwa Y. Ruptured thymoma causing a hemothorax: A case report. Oncol Lett. 2015;10:1810-1812.
• Tane S, Sakai Y, Hokka D, Okuma H, Ogawa H, Tanaka Y, Uchino K, Nishio W, Yoshimura M, Maniwa Y. Significant role of Psf3 expression in non-small-cell lung cancer. Cancer Sci. 2015;106:1625-34.
• Tane S, Nishio W, Okuma H, Ogawa H, Hokka D, Tane K, Tanaka Y, Uchino K, Yoshimura M, Maniwa Y. Operative outcomes of thoracoscopic lobectomy for non-small-cell lung cancer. Asian Cardiovasc Thorac Ann. 2015;23:950-7
• Ogawa H, Uchino K, Tanaka Y, Shimizu N, Okuda Y, Tane K, Tauchi S, Nishio W, Maniwa Y, Yoshimura M. Efficacy of adjuvant chemotherapy for lung adenocarcinoma patients with positive pleural lavage cytology findings. Interact Cardiovasc Thorac Surg. 2015;21:34-9.
• Tomono A, Nakamura T, Otowa Y, Imanishi T, Tanaka Y, Maniwa Y, Kakeji Y. A Case of Benign Esophageal Schwannoma Causing Life-threatening Tracheal Obstruction. Ann Thorac Cardiovasc Surg. 2015;21:289-92.
• Ogawa H, Uchino K, Tanaka Y, Shimizu N, Okuda Y, Tane K, Hokka D, Tane S, Tauchi S, Nishio W, Maniwa Y, Yoshimura M. Outcomes of segmentectomy for cT1bN0M0 lung adenocarcinoma and squamous cell carcinoma: a possible association with pathological invasion. Eur J Cardiothorac Surg. 2015;48:77-82.
• Tanaka Y, Noda K, Isse K, Tobita K, Maniwa Y, Bhama JK, D'Cunha J, Bermudez CA, Luketich JD, Shigemura N. A Novel Dual Ex Vivo Lung Perfusion Technique Improves Immediate Outcomes in an Experimental Model of Lung Transplantation. Am J Transplant. 2015;15:1219-30.
• Hokka D, Uchino K, Tane K, Ogawa H, Tane S, Tanaka Y, Tauchi S, Nishio W, Yoshimura M, Maniwa Y. Pleural lavage cytology as an independent prognostic factor in non-small-cell lung cancer patients with stage I disease and adenocarcinoma. Mol Clin Oncol. 2015 Jan;3:244-248.
• Tane S, Nishio W, Ogawa H, Hokka D, Tane K, Tanaka Y, Tauchi S, Uchino K, Sakai Y, Ohbayashi C, Yoshimura M, Maniwa Y. Clinical significance of the “not otherwise specified" subtype in candidates for resectable non-small cell lung cancer. Oncol Lett. 2014;8:1017-1024.
• Tanaka Y, Shigemura N, Noda K, Kawamura T, Isse K, Stolz DB, Bermudez CA.Optimal lung inflation techniques in a rat lung transplantation model: A revisit. Thorac Cardiovasc Surg. 2014;62:427-33.
• Ogawa H, Tanaka Y, Koma Y, Hokka D, Tane S, Tauchi S, Uchino K, Yoshimura M, Maniwa Y. Pulmonary Large Cell Neuroendocrine Carcinoma showing extensive “pagetoid spread" in the bronchial epithelium. Oncol Lett.2014;8:2621-2623.
• Noda K, Shigemura N, Tanaka Y, Bhama JK, D'Cunha J, Luketich JD, Bermudez CA. Successful prolonged ex vivo lung perfusion for graft preservation in rats. Eur J Cardiothorac Surg. 2014;45:e54-60.
• Noda K, Shigemura N, Tanaka Y, Bhama J, D'Cunha J, Kobayashi H, Luketich JD, Bermudez CA. Hydrogen preconditioning during ex vivo lung perfusion improves the quality of lung grafts in rats. Transplantation. 2014;98:499-506
• Chen X, Hokka D, Maniwa Y, Ohbayashi C, Itoh T, Hayashi Y. Sirt1 is a tumor promoter in lung adenocarcinoma. Oncol Lett. 2014;8:387-393.
• Seki S, Koyama H, Ohno Y, Nishio M, Takenaka D, Maniwa Y, Itoh T, Nishimura Y, Sugimura K.Diffusion-weighted MR imaging vs. multi-detector row CT: Direct comparison of capability for assessment of management needs for anterior mediastinal solitary tumors. Eur J Radiol. 2014;83:835-42.
• Tsuboshima K, Wakahara T, Matoba Y, Miyauchi H, Hayashi C, Kobayashi I, Oue H, Watanabe Y, Ono T, Maniwa Y. Single-incision thoracoscopic surgery using a chest wall pulley for lung excision in patients with primary spontaneous pneumothorax. Surg Today. 2015;45:595-9.
• Tane S, Ohno Y, Hokka D, Ogawa H, Tauchi S, Nishio W, Yoshimura M, Okita Y, Maniwa Y. The efficacy of 320-detector row CT for Assessment of Preoperative Pulmonary Vasculature of Candidates for Pulmonary Segmentectomy. Interact Cardiovasc Thorac Surg. 2013;17:974-80.
• Hokka D, Maniwa Y, Tane S, Nishio W, Yoshimura M, Okita Y, Ohbayashi C, Sakai Y, Chen X, Hayashi Y. Psf3 is a prognostic biomarker in lung adenocarcinoma. Lung Cancer 2013;79:77-82.
• Tane S, Maniwa Y, Hokka D, Tauchi S, Nishio W, Okita Y, Yoshimura M. The role of Necl-5 in the invasive activity of lung adenocarcinoma. Exp Mol Pathol 2013;94:330-5.
• Tanaka Y, Ogawa H, Uchino K, Ohbayashi C, Maniwa Y, Nishio W, Nakao A, Yoshimura M. Immunohistochemical studies of pulmonarylarge cell neuroendocrine carcinoma: a possible association between staining patterns with neuroendocrine markers and tumor response to chemotherapy. J Thorac Cardiovasc Surg 2013;145:839-46.
• Tane S, Nishio W, Hokka D, Maniwa Y, Yoshimura M. Ewing's sarcoma family of tumors originating in the main bronchus. Thoracic Cancer 2012;3:353-356.
• Noda K(※), Tanaka Y(※), Shigemura N, Kawamura T, Wang Y, Masutani K, Sun X, Toyoda Y, Bermudez CA, Nakao A, Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration. Transpl Int 2012;25:1213-22 (※)These authors contributed to this work equally.
• Maniwa Y, Nishio W, Okita Y, Yoshimura M. Expression of Nectin 3: Novel prognostic marker of lung adenocarcinoma. Thoracic Cancer 2012;3:175-181.
• Tanaka Y, Shigemura N, Kawamura T, Noda K, Isse K, Stolz DB, Billiar TR, Toyoda Y, Bermudez CA, Lyons-Weiler J, Nakao. Profiling molecular changes induced by hydrogen treatment of lung allografts prior to procurement. Biochem Biophys Res Commun 2012;425:873-9.
• Tane S, Tanaka Y, Tauchi S, Uchino K, Nakai R, Yoshimura M. Radically resected epithelioid angiosarcoma that originated in the mediastinum. Gen Thorac Cardiovasc Surg 2011;59:503-6.
• Doi T, Maniwa Y, Tanaka Y, Tane S, Hashimoto S, Ohno Y, Nishio W, Nishimura Y, Ohbayashi C, Okita Y, Hayashi Y, Yoshimura M. MT1-MMP plays an important role in an invasive activity of malignant pleural mesothelioma cell.
• Wakahara T, ManiwaY, Tanaka Y, Nishio W, Yoshimura M. Successful management of descending necrotizing mediastinitis. Asian Cardiovasc Thoracic Ann 2011;19:228-231.
• Maniwa Y, Nishio W, Yoshimura M. Application of hRad9 to lung cancer treatment as a molecular marker and a molecular target. Thoracic Cancer 2011;2:7-15.
• Satoh N, Maniwa Y, Bermudez VP, Nishimura K, Nishio W, Yoshimura M, Okita Y, Ohbayashi C, Hurwitz J, Hayashi Y. Oncogenic Phosphatase Wip1 is a Novel Prognostic Marker for Lung Adenocarcinoma Patient Survival. Cancer Sci 2011;102:1101-1106.
• Tanaka Y, Maniwa Y, Bermudez VP, Doi T, Nishio W, Ohbayashi C, Okita Y, Hurwitz J, Hayashi Y, Yoshimura M. Non-synonymous SNPs in DNA damage repair pathways and lung cancer risk. Cancer 2010;116:896-902.
• Maniwa Y, Yoshimura M, Hashimoto S, Takata M, Nishio W. Chemosensitivity of Lung Cancer: Differences between Primary Tumor and Lymph Node Metastasis. Oncology Letters 2010;1:345-349.
• Nakai R, Maniwa Y, Tanaka Y, Nishio W, Yoshimura M, Okita Y, Ohbayashi C, Satoh N, Ogita H, Takai Y, Hayashi Y. Overexpression of Necl-5 correlates with unfavorable prognosis in patients with lung adenocarcinoma. Cancer Sci 2010;101:1326-1330.
• Maekawa T, Maniwa Y, Doi T, Okada K, Nishio W, Yoshimura M, Ohbayashi C, Hayashi Y, Okita Y. Expression and localization of FOXO1 in non-small cell lung cancer. Oncol Rep 2009;22:57-64.
• Maniwa Y, Yoshimura M, Takata M, Nishimura Y, Ohno Y. Effective chemotherapy based on a chemosensitivity test for malignant pleural mesothelioma. Ann Thorac Cardiovasc Surg 2008;14:319-321.
• Yuki T, Maniwa Y, Doi T, Okada K, Nishio W, Hayashi Y, Okita Y. DNA damage sensor protein hRad9-a novel molecular target for lung cancer treatment. Oncol Rep 2008;20:1047-1052.
• Tanaka Y, Maniwa Y, Nishio W, Yoshimura M, Okita Y. The optimal timing to resect pulmonary metastasis. Eur J Cardiothorac Surg 2008;3:1135-1138.
• Takata M, Maniwa Y, Doi T, Tanaka Y, Okada K, Nishio W, Ohbayashi C, Yoshimura M, Hayashi Y, Okita Y. Double-layered collagen gel hemisphere for cell invasion assay: Successful visualization and quantification of cell invasion activity. Cell common adhes 2007;14:157-167.
• Tanaka Y, Maniwa Y, Yoshimura M, Okita Y. Successful treatment of descending necrotizing mediastinitis. Gen Thorac Cardiovasc Surg 2007;55:366-369.
• Maniwa Y, Yoshimura M, Bermudez VP, Obayashi C, Hayashi Y, Hurwitz J, Okita Y. The His239Arg SNP of HRAD9 is associated with Lung Adenocarcinoma. Cancer 2006;106:1117-1122.
• Maniwa Y, Yoshimura M, Bermudez VP, Obayashi C, Hayashi Y, Hurwitz J, Okita Y. Accumulation of hRad9 protein in the nuclei of non-small cell lung cancer (NSCLC) cells. Cancer 2005;103:126-132.
• Harada N, Maniwa Y, Yoshimura M, Nagata M, Hamada H, Yokono K, Okita Y. E1B-deleted Adenovirus replicates in p53-Deficient Lung Cancer Cells because of the Absence of Apoptosis. Oncol Rep;14:1155-1163.
• Maniwa Y, Yoshimura M, Obayashi C, Inaba M, Kiyooka K, Kanki M, Okita Y. The association of p53 gene mutation and telomerase activity in resectable non-small cell lung cancer. Chest 2001;120:589-594.