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Welcome to Nakamura lab!

 

Our lab focus on the molecular mechanism of sphingosine 1-phosphate signaling.

 


Lab news

3/2017 New paper in Scientific Reports.

Extracellular α-synuclein induces sphingosine 1-phosphate receptor subtype 1 uncoupled from inhibitory G-protein leaving β-arrestin signal intact. Zhang, L., Okada, T., Badawy, S., Hirai, C., Kajimoto, T., Nakamura, SI. Sci Rep. 7:44248 . doi:10.1038/srep44248 (2017)

11/2016 New paper in Scientific Reports.

Impairment of PDGF-induced chemotaxis by extracellular α-synuclein through selective inhibition of Rac1 activation. Okada, T., Hirai, C., Badawy, S., Zhang, L., Kajimoto, T., Nakamura, SI. Sci Rep. 6:37810. doi: 10.1038/srep37810 (2016)

11/2013 New paper in Nature Communications.

Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes. Kajimoto, T., Okada, T., Miya, S., Zhang, L., Nakamura, SI. Nat. Commun. 4:2712 doi: 10.1038/ncomms3712 (2013)