PUBLICATION
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亀山武志．(2026)
みにれびゅう: 新規単離精製法により明らかになったアストロサイトエンドフットの脳血管領域依存的な多様性．
生化学, 98(2): 316-320 -
Katanazaka, K., Shiotani, H., Miyata, M., Kameyama, T., Kedashiro, S.,
Komaki, R., Nishii, S., Kashiwagi, Y., Sato, Y., Okabe, S., Chihara, N., Matsumoto, R.,
Mizutani, K., and Takai, Y. (2026)
Localization of Puncta Adherentia Junctions at GABAergic Synapses on Parvalbumin-Positive GABAergic Inhibitory Neurons in the Mouse Hippocampus
J. Comp. Neurol., 534(3): e70152 -
Miyamoto, R., Sakane, A., Morino, H., Kume, K., Matsubara, T., Fukumoto, T., Osaki, Y.,
Oki, R., Hanada, K., Tachibana, K., Nakataki, M., Nishida, Y., Takahashi, Y., Mizuguchi,
K., Murayama, S., Saito, Y., Kawakami, H., Takai, Y., Sasaki, T., and Izumi, Y.
(2026)
An R83W mutation in Rab3A causes autosomal-dominant cerebellar ataxia.
Hum. Mol. Genet., 10;35(3):ddaf186
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Komaki, R., Shiotani, H., Kuriu, T., Kameyama, T., Miyata, M., Kedashiro, S.,
Katanazaka, K., Nishii, S., Chihara, N., Matsumoto, R., Koebis, M., Aiba, A., Mizutani,
K., and Takai, Y. (2025)
Necl-4/CADM4 regulates GABAergic synaptic strength on GABAergic inhibitory neurons via ErbB4 activation and prevents neuronal impairments.
Mol. Neurobiol., 62(12): 15943-15968 -
Ueno, A., Sakuta, K., Ono, H., Hashio, A., Tokumoto, H., Watanabe, M., Nishimoto, T.,
Konishi, T., Emori, Y., Mizuno, S., Hiratsuka, M., Miyoshi, J., Takai, Y., Tachibana,
M., and Koike, C. (2025)
Afadin-deficient mouse retinas exhibit severe neuronal lamination defects but preserve visual functions.
elife, 14: RP105627
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Kawashima, R., Matsushita, K., Mandai, K., Sugita, Y., Maruo, T., Mizutani, K., Midoh,
Y., Oguchi, A., Murakawa, Y., Kuniyoshi, K., Sato, R., Furukawa, T., Nishida, K., and
Takai, Y. (2024)
Necl-1/CADM3 regulates cone synapse formation in the mouse retina.
iScience, 27(4):109577
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Kameyama, T., Miyata, M., Shiotani, H., Adachi, J., Kakuta, S., Uchiyama, Y., Mizutani,
K., and Takai, Y. (2023)
Heterogeneity of perivascular astrocyte endfeet depending on vascular regions in the mouse brain.
iScience, 26(10): 108010 -
Maruo, T., Mizutani, K., Miyata, M., Kuriu, T., Sakakibara, S., Takahashi, H., Kida, D.,
Maesaka, K., Sugaya, T., Sakane, A., Sasaki, T., Takai, Y., and Mandai, K. (2023)
s-Afadin binds to MAGUIN/Cnksr2 and regulates the localization of the AMPA receptor and glutamatergic synaptic response in hippocampal neurons.
J. Biol. Chem., 299(4): 103040
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Nozawa, O., Miyata, M., Shiotani, H., Kameyama, T., Komaki, R., Shimizu, T., Kuriu, T.,
Kashiwagi, Y., Sato, Y., Koebisu, M., Aiba, A., Okabe, S., Mizutani, K., and Takai, Y.
(2022)
Necl2/3-mediated mechanism for tripartite synapse formation.
Development, 150(4): dev200931 -
Kedashiro, S., Kameyama, T., Mizutani, K., and Takai, Y. (2022)
Stimulatory role of nectin-4 and p95-ErbB2 in multilayered T47D cell proliferation.
Genes Cells, 27(6): 451-464 -
Sakakibara, S., Sakane, A., Sasaki, T., Shinohara, M., Maruo, T., Miyata, M., Mizutani,
K., and Takai, Y. (2022)
Identification of lysophosphatidic acid in serum as a factor that promotes epithelial apical junctional complex organization.
J. Biol. Chem., 298(10): 102426 -
Lohani, S., Funato, Y., Akieda, Y., Mizutani, K., Takai, Y., Ishitai, T., and Miki, H.
(2022)
A novel role of PRL in regulating epithelial cell density by inducing apoptosis at confluence.
J. Cell Sci., 135(2): jcs258550
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Russo, E., Runge, P., Jahromi, NH., Naboth, H., Landtwing, A., Montecchi, R., Leicht,
N., Hunter, MC., Takai, Y., and Halin, C. (2021)
CD112 regulates angiogenesis and T cell entry into the spleen.
Cells, 10(1): 169 -
Furuse, M., and Takai, Y. (2021)
Recent advances in understanding tight junctions.
Fac. Rev., 10: 18 -
Sugiura, A., Kameyama, T., Maruo, T., Kedashiro, S., Miyata, M., Mizutani, K., and
Takai, Y. (2021)
Identification of Sox2 and NeuN double-positive cells in the mouse hypothalamic arcuate nucleus and their reduction in number with aging.
Front. Aging Neurosci., 12: 609911 -
Nishimura, T., Oyama, T., Hu, HT, Fujioka, T., Hanawa-Suetsugu, K., Ikeda, K., Yamada,
S., Kawana, H., Sagisusa, D., Ikeda, H., Kurata, R., Oono-Yakura, K., Kitamata, M.,
Kida, K., Hikita, T., Mizutani, K., Yasuhara, K., Mimori-Kiyosue Y., Oneyama, C.,
Kurimoto, K., Hosokawa, Y., Aoki, J., Takai, Y., Arita, M., and Suetsugu, S. (2021)
Filopodium-derived vesicles produced by MIM enhance the migration of recipient cells.
Dev. Cell., 56(6): 842-859 -
Kedashiro, S., Kameyama, T., Mizutani, K., and Takai, Y. (2021)
Nectin-4 and p95-ErbB2 cooperatively regulate Hippo signaling-dependent SOX2 gene expression, enhancing anchorage-independent T47D cell proliferation.
Sci. Rep., 11(1): 7344 -
Mizutani, K., Miyata, M., Shiotani, H., Kameyama, T., and Takai, Y. (2021)
Nectin-2 in general and in the brain.
Mol. Cell. Biochem., 477(1): 167-180 -
Mizutani, K., Miyata, M., Shiotani, H., Kameyama, T., and Takai, Y. (2021)
Nectins and Nectin-like molecules in synapse formation and involvement in neurological diseases.
Mol. Cell. Neurosci., 115: 103653 -
Mizutani, K., and Takai, Y. (2021)
Changes in brain synapse-related molecules with age.
In Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet(eds. Martin, C., Preedy, V., and Rajendram, R.), Pages 185-198, Academic Press
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Sakakibara, S., Mizutani, K., Sugiura, A., Sakane A., Sasaki, T., Yonemura, S., and
Takai, Y. (2020)
Afadin regulates actomyosin organization through αE-catenin at adherens junctions.
J. Cell Biol., 219(5): e201907079 -
Luo, L., Ambrozkiewicz, M.C. Benseler, F., Chen, C., Dumontier, E., Falkner, S.,
Furlanis, E., Gomez, A.M., Hoshina, N., Huang, Wei-Hsiang, Hutchison, M.A.,
Itoh-Maruoka, Y., Lavery, L.A., Li, W., Maruo, T., Motohashi, J., Pai, E Ling-Lin,
Pelkey, K.A., Pereira, A., Philips, T., Sinclair, J.L., Stogsdill, J.A., Traunmüller,
L., Wang, J., Wortel, J., You, W., Abumaria, N., Beier, K.T., Brose, N., Burgess, HA.,
Cepko, CL., Cloutier, Jean-François, Eroglu, C., Goebbels, S., Kaeser, P.S., Kay, J.N.,
Lu, W., Luo, L., Mandai, K., McBain, C.J., Nave, Klaus-Armin, Prado, M.A.M., Prado,
V.F., Rothstein, J., Rubenstein, J.L.R., Saher, G., Sakimura, K., Sanes, J.R.,
Scheiffele, P., Takai, Y., Umemori, H., Verhage, M., Yuzaki, M., Zoghbi, H.Y., Kawabe,
H., and Craig, A.M. (2020)
Optimizing nervous system-specific gene targeting with cre driver lines: Prevalence of germline recombination and influencing factors.
Neuron, 106(1): 37-65 -
Shiotani, H., Miyata, M., Kameyama, T., Mandai K., Yamasaki, M., Watanabe, M., Mizutani,
K., and Takai, Y. (2020)
Nectin-2α is localized at cholinergic neuron dendrites and regulates synapse formation in the medial habenula.
J. Comp. Neurol., 529(2): 450-477
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Shiotani, H., Miyata, M., Mizutani, K., Wang, S., Mizoguchi, A., Mochizuki, H., Mandai,
K., and Takai, Y. (2019)
Interaction of nectin-2α with the auxiliary subunit of the voltage-gated A-type K+ channel Kv4.2 dipeptidyl aminopeptidase-like protein at the boundary between the adjacent somata of clustered cholinergic neurons in the medial habenula.
Mol. Cell. Neurosci., 94: 32-40 -
Kedashiro, S., Sugiura, A., Mizutani, K., and Takai, Y. (2019)
Nectin-4 cis-interacts with ErbB2 and its trastuzumab-resistant splice variants, enhancing their activation and DNA synthesis.
Sci. Rep., 9(1): 18997
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Sakakibara, S., Maruo, T., Miyata, M., Mizutani, K., and Takai, Y. (2018)
Requirement of the F-actin-binding activity of l-afadin for enhancing the formation of adherens and tight junctions.
Genes Cells, 23(3): 185-199 -
Ueda, Y., Kedashiro, S., Maruoka, M., Mizutani, K., and Takai, Y. (2018)
Roles of the third Ig-like domain of Necl-5/PVR and the fifth Ig-like domain of the PDGF receptor in its signaling.
Genes Cells, 23(3): 214-224 -
Shiotani, H., Miyata, M., Itoh, Y., Wang, S., Kaito, A., Miozguchi, A., Yamasaki, M.,
Watanabe, M., Mandai, K., Mochizuki, H., and Takai, Y. (2018)
Localization of nectin-2α at the boundary between the adjacent somata of the clustered cholinergic neurons and its regulatory role in the subcellular localization of the voltage-gated A-type K+ channel Kv4.2 in the medial habenula.
J. Comp. Neurol., 526(9): 1527-1549 -
Maruo, T., Sakakibara, S., Miyata, M., Itoh, Y., Kurita, S., Mandai, K., Sasaki, T., and
Takai, Y. (2018)
Involvement of l-afadin, but not s-afadin, in the formation of puncta adherentia junctions of hippocampal synapses.
Mol. Cell. Neurosci., 92: 40-49 -
Tagashira, T., Fukuda, T., Miyata, M., Takai, Y., Hirata, K., and Rikitake Y. (2018)
Afadin facilitates vascular endothelial growthfactor-induced network formation and migration of vascular endothelial cells by inactivating Rho-associated kinase through ArhGAP29.
Arterioscler. Thromb. Vasc. Biol., 38(5): 1159-1169
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Maruoka, M., Kedashiro, S., Ueda, Y., Mizutani, K., and Takai, Y. (2017)
Nectin-4 co-stimulates the prolactin receptor by interacting with SOCS1 and inhibiting its activity on the JAK2-STAT5a signaling pathway.
J. Biol. Chem., 292(17): 6895-6909 -
Miyata, M., Maruo, T., Kaito, A., Wang, S., Yamamoto, H., Fujiwara, T., Mizoguchi, A.,
Mandai, K., and Takai, Y. (2017)
Roles of afadin in the formation of the cellular architecture of the mouse hippocampus and dentate gyrus.
Mol. Cell. Neurosci., 79: 34-44 -
Shiotani,H., Maruo, T., Sakakibara,S., Miyata, M., Mandai, K., Mochizuki, H., and Takai,
Y. (2017)
Aging-dependent expression of synapse-related proteins in the mouse brain.
Genes Cells, 22(5): 472-484 -
Maruo, T., Mandai, K., Miyata, M., Sakakibara, S., Wang, S., Sai, K., Itoh, Y., Kaito,
A., Fujiwara, T., Mizoguchi, A., and Takai, Y. (2017)
NGL-3-induced presynaptic differentiation of hippocampal neurons in an afadin-dependent, nectin-1-independent manner.
Genes Cells, 22(8): 742-755 -
Sai, K., Wang, S., Kaito, A., Fujiwara, T., Maruo, T., Itoh, Y., Miyata, M., Sakakibara,
S., Miyazaki, N., Murata, K., Yamaguchi, Y., Haruta, T., Nishioka, H., Motojima, Y.,
Komura, M., Kimura, K., Mandai, K., Takai, Y., and Mozuguchi, A. (2017)
Multiple Roles of afadin in the ultrastructural morphogenesis of mouse hippocampal mossy fiber synapses.
J. Comp. Neurol., 525(12): 2719-2734 -
Geng, X., Maruo, T., Mandai, K., Supriyanto, I., Miyata, M., Sakakibara, S., Mizoguchi,
A., Takai, Y., and Mori, M. (2017)
Roles of afadin in functional differentiations of hippocampal mossy fiber synapse.
Genes Cells, 22(8): 715-722 -
Kawashima, T., Takito, J., Shimada, Y., Sato, M., Inoue, M., Miyazaki, T., Miyata, M.,
Rikitake, Y., Takai Y., and Nakamura, M. (2017)
Dynamic expression of nectins in enamle organs of mouse incisors.
J. Oral Biosci., 59(3): 172-178 -
Mizutani, K., Kedashiro, S., and Takai, Y. (2017)
Nectin-like molecule-4/cell adhesion molecule 4 inhibits the ligand-induced dimerization of ErbB3 with ErbB2.
Sci. Rep., 7(1): 11375
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Kitayama, M., Mizutani, K., Maruoka, M., Mandai, K., Sakakibara, S., Ueda, Y., Komori,
T., Shimono, Y., and Takai , Y. (2016)
A novel nectin-mediated cell adhesion apparatus that is implicated in prolactin receptor signaling for mammary gland development.
J. Biol. Chem., 291(11): 5817-5831 -
Katsunuma, S., Honda, H., Shinoda, T., Ishimoto, Y., Miyata, T., Kiyonari, H., Abe, T.,
Nibu, K., Takai, Y., and Togashi, H. (2016)
Synergistic action of nectins and cadherins generates the mosaic cellular pattern of the olfactory epithelium.
J. Cell Biol., 212(5): 561-575 -
Geng, X., Mandai, K., Maruo, T., Wang, S., Fujiwara, T., Mizoguchi, A., Takai, Y., and
Mori, M. (2016)
Regulatory role of the cell adhesion molecule nectin-1 in GABAergic inhibitory synaptic transmission in the CA3 region of mouse hippocampus.
Genes Cells, 21(1): 88-98 -
Kobayashi, S., Hida, Y., Ishizaki, H., Inoue, E., Tanaka-Okamoto, M., Yamasaki, M.,
Miyazaki, T., Fukaya, M., Kitajima, I., Takai, Y., Watanabe, M., Ohtsuka, T., and
Manabe, T. (2016)
The active zone protein CAST regulates synaptic vesicle recycling and quantal size in the mouse hippocampus.
Eur. J. Neurosci., 44(5): 2272-2284 -
Miyata, M., Mandai, K., Maruo, T., Sato, J., Shiotani, H., Kaito, A., Itoh, Y., Wang,
S., Fujiwara, T., Mizoguchi, A., Takai, Y., and Rikitake, Y. (2016)
Localization of nectin-2δ at perivascular astrocytic endfoot processes and degeneration of astrocytes and neurons in nectin-2 knockout mouse brain.
Brain Res., 1649(Pt A): 90-101 -
Mizutani, K., and Takai, Y. (2016)
Nectin spot: a novel type of nectin-mediated cell adhesion apparatus.
Biochem. J., 473(18): 2691-2715 -
Fujiwara, T., Mizoguchi, A., and Takai, Y. (2016)
Cooperative roles of nectins with cadherins in physiological and pathological Processes.
In The Cadherin Superfamily: Key Regulators of Animal Development and Physiology (Suzuki, S.T., Hirano, S., eds.), pp. 115-156, Springer Japan, 2016/6/19 published
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Inoue, T., Fujiwara, T., Rikitake, Y., Maruo, T., Mandai, K., Kimura, K., Kayahara, T.,
Wang, S., Ioth, Y., Sai, K., Mori, M., Mori, K., Mizoguchi, A., and Takai, Y. (2015)
Nectin-1 spots as a novel adhesion apparatus that tethers mitral cell lateral dendrites in a dendritic meshwork structure of the developing mouse olfactory bulb.
J. Comp. Neurol., 523(12): 1824-1839 -
Nobutani, K., Shimono, Y., Mizutani, K. Ueda, Y., Suzuki, T., Kitayama, M., Minami, A.,
Momose, K., Miyawaki, K., Akashi, K., Azuma, T., and Takai, Y. (2015)
Downregulation of CXCR4 in metastasized breast cancer cells and implication in their dormancy.
PLoS One, 10(6): e130032 -
Nakata, H., Wakayama, T., Takai, Y., and Iseki, S. (2015)
Quantitative analysis of the cellular composition in seminiferous tubules in normal and genetically modified infertile mice.
J. Histochem. Cytochem., 63(2): 99-113 -
Fujiwara, Y., Goda, N., Tamashiro, T., Narita, H., Satomura, K., Tenno, T., Nakagawa,
A., Oda, M., Suzuki, M., Sakisaka, T., Takai, Y., and Hiroaki, H. (2015)
Crystal structure of afadin PDZ domain-nectin-3 complex shows the structural plasticity of the ligand-binding site.
Protein Sci., 24(3): 376-385 -
Pujari, R., Hunte, R., Thomas, R., Weyden, L.V.D., Rauch, D., Rauch, D., Ramos, J.C.,
Takai, Y., and Shembade, N. (2015)
Human T-cell leukemia virus type 1 (HTLV-1) Tax requires CADM1/TSLC1 for inactivation of the NF-κB inhibitor A20 and constitutive NF-κB signaling.
PLoS Pathog., 11(3): e1004721 -
Yamana, S., Tokiyama, A., Mizutani, K., Hirata, K., Takai Y., and Rikitake Y. (2015)
The cell adhesion molecule Necl-4/CADM4 serves as a novel regulator for contact inhibition of cell movement and proliferation.
PLoS One, 10(4): e0124259 -
Yamamoto, H., Mandai, K., Konno, D., Maruo, T., Matsuzaki, F., and Takai, Y. (2015)
Impairment of radial glial scaffold-dependent neuronal migration and formation of double cortex by genetic ablation of afadin.
Brain Res., 1620: 139-152 -
Fujiwara, T., Inoue, T., Maruo, T., Rikitake, Y., Ieki, N., Mandai, K., Kimura, K.,
Kayahara, T., Wang, S., Itoh, Y., Sai, K., Mori, M., Mori, K., Takai Y., and Mizoguchi,
A. (2015)
Nectin-1 spots regulate the branching of olfactory mitral cell dendrites.
Mol. Cell. Neurosci., 68: 143-150 -
Mandai, K., Rikitake, Y., Mori, M., and Takai, Y. (2015)
Nectins and nectin-like molecules in development and disease.
Curr. Top. Dev. Biol., 112: 197-231 -
Maruo, T., Mandai, K., Takai, Y., and Mori., M. (2016)
Activity-dependent alteration of the morphology of a hippocampal giant synapse.
Mol. Cell. Neurosci., 71: 25-33 -
Nakanishi, H., and Takai, Y. (2015)
Frabin
In Encyclopedia of Signaling Molecules, ed. Choi, S., pp.670-674, Springer, New York
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Fukuda, T., Kominami, K., Wang, S., Togashi, H., Hirata, K., Mizoguchi, A., Rikitake,
Y., and Takai, Y. (2014)
Aberrant cochlear hair cell attachments caused by nectin-3 deficiency result in hair bundle abnormalities.
Development, 141(2): 399-409 -
Toyoshima, D., Mandai, K., Maruo, T., Supriyanto, I., Togashi, H., Inoue, T., Mori, M.,
and Takai, Y. (2014)
Afadin regulates puncta adherentia junction formation and presynaptic differentiation in hippocampal neurons.
PLoS One, 9(2): e89763 -
Tanaka-Okamoto, M., Itoh, Y., Miyoshi, J., Mizoguchi, A., Mizutani, K., Takai, Y., and
Inoue, M. (2014)
Genetic ablation of afadin causes mislocalization and deformation of Paneth cells in the mouse small intestinal epithelium.
PLoS One, 9(10): e110549 -
Nobutani, K., Shimono, Y., Yoshida, M., Mizutani, K., Minami, A., Kono, S., Mukohara,
T., Yamasaki, T., Itoh, T., Takao, S., Minami, H., Azuma, T., and Takai, Y. (2014)
Absence of primary cilia in cell cycle-arrested human breast cancer cells.
Genes Cells, 19(2): 141-152 -
Suzuki, T., Mizutani, K., Minami, A., Nobutani, K., Kurita, S., Nagino, M., Shimono, Y.,
and Takai, Y. (2014)
Suppression of the TGF-β1-induced protein expression of SNAI1 and N-cadherin by miR-199a.
Genes Cells, 19(9): 667-675 -
Yoshida, T., Iwata, T., Takai, Y., Birchmeier, W., Yamato, M., and Okano, T. (2014)
Afadin requirement for cytokine expressions in keratinocytes during chemically induced inflammation in mice.
Genes Cells, 19(11): 842-852 -
Kobayashi, R., Kurita, S., Miyata, M., Maruo, T., Mandai, K., Rikitake Y., and Takai Y.
(2014)
s-Afadin binds more preferentially to the cell adhesion molecules nectins than l-afadin.
Genes Cells, 19(12): 853-863 -
Zhu, Q., Yamakuchi, M., Ture, S., de la Luz Garcia-Hernandez, M., Ko, K.A., Modjeski,
K.L., LoMonaco, M.B., Johnson, A.D., O’Donnell, C.J., Takai, Y., Morrell, C.N., and
Lowenstein, C.J. (2014)
Syntaxin-binding protein STXBP5 inhibits endothelial exocytosis and promotes platelet secretion.
J. Clin. Invest., 124(10): 4503-4516 -
Ye, S., Huang, Y., Joshi, S., Zhang, J., Yang, F., Zhang, G., Smyth, S.S., Li, Z.,
Takai, Y., and Whiteheart, S.W. (2014)
STXBP5/Tomosyn-1 is Critical for Platelet Secretion and Thrombosis.
J. Clin. Invest., 124, 10, 4517-4528. Oct 1 -
Yoshida, T., Takai, Y., and Thesleff, I. (2014)
Cooperation of nectin-1 and nectin-3 is required for maintenance of epidermal stratification and proper hair shaft formation in the mouse.
Developmental Biology Journal, vol. 2014, Article ID 432043, 12 pages, 2014. doi:10.1155/2014/432043. -
Mori, M., Rikitake, Y., Mandai, K., and Takai, Y. (2014)
Roles of nectins and nectin-like molecules in the nervous system.
Adv. Neurobiol. 8, 91-116 (Review)
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Minami, A., Shimono, Y., Mizutani, K., Nobutani, K., Momose, K.,Azuma, T., and Takai, Y.
(2013)
Reduction of the ST6 β-galactosamide α-2,6-sialyltransferase 1 (ST6GAL1)-catalyzed sialylation of nectin-like molecule 2/cell adhesion molecule 1 and enhancement of ErbB2/ErbB3 signaling by microRNA-199a
J. Biol. Chem. , 288(17): 11845-11853 -
Kurita, S., Yamada, T., Rikitsu, E., Ikeda, W., and Takai, Y. (2013)
Binding between the junctional proteins afadin and PLEKHA7 and implication in the formation of adherens junction in epithelial cells.
J. Biol. Chem. , 288(41): 29356-29368 -
Yamada, A., Inoue, E., Deguchi-Tawarada, M., Matsui, C., Togawa, A., Nakatani, T., Ono,
Y., and Takai, Y. (2013)
Necl-2/CADM1 interacts with ErbB4 and regulates its activity in GABAergic neurons.
Mol. Cell. Neurosci. , 56: 234-243 -
Komaki, R., Togashi, H., and Takai, Y. (2013)
Regulation of dendritic filopodial interactions by ZO-1 and implications for dendrite morphogenesis.
PLoS One , 8(10): e76201 -
Yamamoto, H., Maruo, T., Majima, T., Ishizaki, H., Tanaka-Okamoto, M., Miyoshi, J.,
Mandai, K., and Takai Y. (2013)
Genetic deletion of afadin causes hydrocephalus by destruction of adherens junctions in radial glial and ependymal cells in the midbrain.
PLoS One , 8(11): e80356 -
Momose, K., Minami, A., Shimono, Y., Mizutani, K., Nobutani, K., Azuma, T., and Takai,
Y. (2013)
miR-214 and Hypoxia Down-regulate Necl-2/CADM1 and enhance ErbB2/ErbB3 Signaling.
Genes Cells , 18(3): 195-202 -
Sugiyama, H., Mizutani, K., Kurita, S., Okimoto, N., Shimono, Y., and Takai, Y.
(2013)
Interaction of Necl-4/CADM4 with ErbB3 and integrin α6β4 and inhibition of ErbB2/ErbB3 signaling and hemidesmosome disassembly.
Genes Cells , 18(6): 519-528 -
Yamada, T., Kuramitsu, K., Rikitsu, E., Kurita, S., Ikeda, W., and Takai, Y. (2013)
Nectin and junctional adhesion molecule are critical cell adhesion molecules for the apico-basal alignment of adherens and tight junctions in epithelial cells.
Genes Cells , 18(11): 985-998 -
Du, M., Young, J’N., Asis, MD., Cipollone, J., Roskelley, C., Takai, Y., Nicolls, P.,
Stanton, P., Deng, W., Finlay B., and Vogl, A.W. (2013)
A Novel Subcellular Machine Contributes to Basal Junction Remodeling in the Seminiferous Epithelium.
Biol. Reprod. , 88(3): 60 -
Kureha, F., Satomi-Kobayashi, S., Kubo, Y., Kinugasa, M., Ishida, T., Takai, Y., Hirata,
K., and Rikitake, Y. (2013)
Nectin-like molecule-5 regulates intimal thickening after carotid artery ligation in mice.
Arterioscler. Thromb. Vasc. Biol. , 33(6): 1206-1211 -
Tanaka, S., Fukumoto, Y., Nochioka, K., Minami, T., Kudo, S., Shiba, N., Takai, Y.,
Williams, C.L., Liao, J.K., and Shimokawa, H.
Statins exert the pleiotropic effects through small GTP-binding protein dissociation stimulator upregulation with a resultant Rac1 degradation.
Arterioscler. Thromb. Vasc. Biol., 33(7): 1591-1600 -
Kamran, N., Takai, Y., Miyoshi, J., Biswas, S.K., Wong, J.S., and Gasser, S. (2013)
Toll-like receptor ligands induce expression of the costimulatory molecule CD155 on antigen-pressenting cells.
PLoS One, 8(1): e54406 -
Ratta-apha, W., Hishimoto, A., Mouri, K., Shiroiwa, K., Sasada, T., Yoshida, M.,
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