HOME | 原著論文(2009~)


  • Takahashi R, Kamizaki K, Yamanaka K, Terai Y, Minami Y.
    Expression of Ferredoxin1 in cisplatin-resistant ovarian cancer cells confers their resistance against ferroptosis induced by cisplatin.
    Oncol. Rep. 2023 May 5.
  • Tanaka Y, Minami Y, and Endo M.
    Ror1 promotes PPARa-mediated fatty acid metabolism in astrocytes.
    Genes Cells. 2023 Apr 28.
  • Kikuchi A, Takagi J, Takada S, Ishitani T, and Minami Y.
    Meeting Report: Wnt 2022 EMBO| The Company of Biologists Workshop and Yamada Conference. Genes Cells, 2023 Apr 28.
    Genes Cells. 2023 Apr 28.


  • Ishikawa T, Ogura Y, Tanaka K, Nagashima H, Sasayama T, Endo M, Minami Y.
    Ror1 is expressed inducibly by Notch and hypoxia signaling and regulates stem cell-like property of glioblastoma cells.
    Cancer Sci. 2022 Oct 31.
  • Saji T, Nishita M, Ikeda K, Endo M, Okada Y, Minami Y.
    c-Src-mediated phosphorylation and activation of kinesin KIF1C promotes elongation of invadopodia in cancer cells.
    J Biol Chem. 2022 May 30.
  • Okamoto D, Yamauchi N, Takiguchi G, Nishita M, Kakeji Y, Minami Y, Kamizaki K.
    Autonomous and intercellular chemokine signaling elicited from mesenchymal stem cells regulates migration of undifferentiated gastric cancer cells.
    Genes Cells. 2022 Mar 9.


  • Honda H.
    Left-handed cardiac looping by cell chirality is mediated by position-specific convergent extensions.
    Bopphys J. 2021 Dec 7.
  • Murao N, Yokoi N, Takahashi H, Hayami T, Minami Y, Seino S.
    Increased glycolysis affects b cell function and identity in aging and diabetes.
    Mol. Metab. 2021 Dec 1.
  • Sonoda D, Kamizaki K, Matsuo Y, Aruga K, Mikubo M, Yamashita K, Nishita M, Minami Y, Satoh Y
    Characterization of morphological alterations in micropapillary adenocarcinoma of the lung using an established cell line.
    Oncol Rep. 2021 Nov 19.
  • Alcantara M. C., Suzuki K., Acebedo A. R., Sakamoto Y., Nishita M., Minami Y., Kikuchi A, Yamada, G.
    Stage-dependent function of Wnt5a during male external genitalia development.
    Congenital Anomalies. 2021 July 13.
  • Avincsal MO, Kamizaki K, Jimbo N, Shinomiya H, Nibu K, Nishita M, Minami Y.
    Oncogenic E6 and/or E7 proteins drive proliferation and invasion of human papilloma virus‑positive head and neck squamous cell cancer through upregulation of Ror2 expression
    Oncol Rep. 2021 May 31.
  • Nishida H, Okada M, Yang L, Takano T, Tabata S, Soga T, Ho DM, Chung J, Minami Y, Yoo SK.
    Methionine restriction breaks obligatory coupling of cell proliferation and death by an oncogene Src in Drosophila
    eLife. 2021 Apr 27.


  • Oduori OS, Murao N, Shimomura K, Takahashi H, Zhang Q, Dou H, Sakai S, Minami K, Chanclon B, Guida C, Kothegala L, Tolö J, Maejima Y, Yokoi N, Minami Y, Miki T, Rorsman P, Seino S.
    Gs/Gq signaling switch in β cells defines incretin effectiveness in diabetes
    J Clin Invest. 2020 Nov 16.
  • Hashimoto M, Kumabe A, Kim JD, Murata K, Sowmya S, Williams A, Lu W, Ishida J, Nakagawa T, Endo M, Minami Y, Fukamizu A.
    Loss of PRMT1 in the central nervous system (CNS) induces reactive astrocytes and microglia during postnatal brain development
    J. Neurochem. 2020 Aug 16.
  • Honda H, Abe T, Fujimori T.
    The Chiral Looping of the Embryonic Heart Is Formed by the Combination of Three Axial Asymmetries
    Biophs J. 2020 Feb 4.
  • Ikeda T, Nishita M, Hoshi K, Honda T, Kakeji Y, Minami Y.
    Mesenchymal stem cell-derived CXCL16 promotes progression of gastric cancer cells by STAT3-mediated expression of Ror1
    Cancer Sci. 2020 Feb 3
  • Endo M, Tanaka Y, Otsuka M, Minami Y.
    E2F1-Ror2 signaling mediates coordinated transcriptional regulation to promote G1/S phase transition in bFGF-stimulated NIH/3T3 fibroblasts
    FASEB J. 2020 Jan 10.


  • Miao W, Sakai K, Sato H, Imamura R, Jangphattananont N, Takagi J, Nishita M, Minami Y, Matsumoto K.
    Impaired ligand-dependent MET activation caused by an extracellularSEMA domain missense mutation in lung cancer
    Cancer Sci. 2019 Jul 24.
  • Aoki T, Nishita M, Sonoda J, Ikeda T, Kakeji Y, Minami Y.
    IFT20 promotes collective cancer cell invasion by regulating polarized organization of Golgi-associated microtubules.
    Cancer Sci. 2019 Apr;
  • Weissenbock M, Latham R, Nishita M, Wolff LI, Ho HH, Minami Y, Hartmann C.
    Genetic interactions between Ror2 and Wnt9a, Ror1 and Wnt9a and Ror2 and Ror1 - phenotypic analysis of the limb skeleton and palate in compound mutants.
    Genes Cells. 2019 Apr


  • Narumi T, Uemichi K, Honda H, Osaki H.
    Self-organization at the first stage of honeycomb construction: Analysis of an attachment-excavation model
    PLoS One. 2018 Oct 24
  • Kishimoto K, Tamura M, Nishita M, Minami Y, Yamaoka A, Abe T, Shigeta M, Morimoto M.
    Synchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus.
    Nat Commun. 2018 Jul 19
  • Saji T, Nishita M, Ogawa H, Doi T, Sakai Y, Maniwa Y, Minami Y.
    Critical role of the Ror-family of receptor tyrosine kinase in invasion and proliferation of malignant pleural mesothelioma cells.
    Genes Cells. 2018 Jul
  • Inaki M, Hatori R, Nakazawa N, Okumura T, Ishibashi T, Kikuta J, IshiiM, Matuno K, Honda H.
    Chiral cell sliding drives left-right asymmetric organ twisting.
    Elife. 2018 June 12
  • Sudo A, Kanagawa M, Kondo M, Ito C, Kobayashi K, Endo M, Minami Y, Aiba A, Toda T.
    Temporal requirement of dystroglycan glycosylation during brain development and rescue of severe cortical dysplasia via gene delivery in the fetal stage.
    Hum. Mol. Genet. 2018 Apr 1
  • Nagai T, Honda H, Takemura M.
    Simulation of Cell Patterning Triggered by Cell Death and Differential Adhesion in Drosophila Wing.
    Hum. Mol. Genet. 2018 Feb 27


  • Takahashi D, Suzuki H, Kakei Y, Yamakoshi K, Minami Y, Komori T, Nishita M.
    Expression of Ror2 associated with fibrosis of the submandibular gland.
    Cell Struct. Funct. 2017 Dec 20.
  • Uehara S, Udagawa N, Mukai H, Ishihara A, Maeda K, Yamashita T, Murakami K, Nshita M, Nakamura T, Kato S, Minami Y, Takahashi N, Kobayashi Y.
    Protein kinase N3 promotes bone resorption by osteoclasts in response to Wnt5a-Ror2 signaling.
    Sci. Signal. 2017 Aug 29
  • Kamizaki K, Doi R, Hayashi M, Saji T, Kanagawa M, Toda T, Fukada SI, Ho HH, Greenberg ME, Endo M, Minami Y.
    The Ror1 receptor tyrosine kinase plays a critical role in regulating satellite cell proliferation during regeneration of injured muscle. doi: 10.1074/jbc.M117.785709
    J. Biol. Chem. 2017 Sep 22
  • Kessenbrock K., Smith P., Steenbeek S., Pervolarakis N., Kumar R., Minami Y., Goga A., Hinck L., Werb Z.
    Diverse regulation of mammary epithelial growth and branching morphogenesis through non-canonical Wnt signaling.
    Proc. Natl. Acad. Sci. USA, 2017 Mar 21
  • Nishita M, Park SY, Nishio T, Kamizaki K, Wang Z, Tamada K, Takumi T, Hashimoto R, Otani H, Pazour GJ, Hsu VW, Minami Y.
    Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness.
    Sci. Rep. 2017 Jan 26
  • Endo M, Ubulkasim G, Kobayashi C, Onishi R, Aiba A, Minami Y.
    Critical role of Ror2 receptor tyrosine kinase in regulating cell cycle progression of reactive astrocytes following brain injury.
    Glia. 2017 Jan


  • Diaz-Horta O, Abad C, Sennaroglu L, Foster J, DeSmidt A, Bademci G, Tokgoz-Yilmaz S, Duman D, Cengiz FB, Grati M, Fitoz S, Liu XZ, Farooq A, Imtiaz F, Currall BB, Morton CC, Nishita M, Minami Y, Lu Z, Walz K, Tekin M.
    ROR1 is essential for proper innervation of auditory hair cells and hearing in humans and mice.
    Proc Natl Acad Sci USA. 2016 May 24
  • Qi, X., Okinaka, Y., Nishita, M., and Minami, Y.
    Essential role of Wnt5a-Ror1/Ror2 signaling in metanephric mesenchyme and ureteric bud formation.
    Genes Cells. 2016 Apr
  • Takiguchi, G., Nishita, M., Kurita, K., Kakeji, Y., and Minami, Y.
    Wnt5a-Ror2 signaling in mesenchymal stem cells promotes proliferation of gastric cancer cells by activating CXCL16-CXCR6 axis.
    Cancer Sci. 2016 Mar
  • Katsunuma S, Honda H, Shinoda T, Ishimoto Y, Miyata T, kiyounari H, Abe T, Nibu K, Takai Y, Togashi H.
    Synergistic action of nectins and cadherins generates the mosaic cellular pattern of the olfactory epitheliume.
    J Cell Biol. 2016 Feb 29


  • Sato A, Kayama H, Shojima K, Matsumoto S, Koyama H, Minami Y, Nojima S, Morii E, Honda H, Takeda K, Kikuchi A.
    The Wnt5a-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-γ in colitis.
    Sci. Rep. 2015 July 1
  • Takiguchi G, Nishita M, Kurita K, Kakeji Y, Minami Y.
    Wnt5a-Ror2 signaling in mesenchymal stem cells promotes proliferation of gastric cancer cells by activating CXCL16-CXCR6 axis.
    Cancer Sci. 2015 Mar


  • Nishita, M., Qiao, S., Miyamoto, M., Okinaka, Y., M., Yamada, M., Hashimoto, R., Iijima, K., Otani, H., Hartmann, C., Nishinakamura, R., and Minami, Y.
    Role of Wnt5a-Ror2 signaling in morphogenesis of the metanephric mesenchyme during ureteric budding.
    Mol. Cell. Biol. 34 (16): 3096-3105, 2014.
  • Mori, K., Kitazawa, R., Kondo, T., Mori, M., Hamada, Y., Nishita, M., Minami, Y., Haraguchi, R., Takahashi, Y., and Kitazawa, S.
    Diabetic osteopenia by decreased β-catenin signaling is partly induced by epigenetic derepression of sFRP-4 gene.
    PLoS One 9 (7): e102797, 2014.
  • Okamoto, M., Udagawa, N., Yamashita, T., Nakamichi, Y., Uehara, S., Kato, H., Saito, N., Minami, Y., Takahashi, N., and Kobayashi, Y.
    Noncanonical Wnt5a enhances Wnt/ β-catenin signaling during osteogenesis.
    Scientific Report 4: 4493, 2014.
  • Doi, R., Endo, M., Yamakoshi, K., Yamanashi, Y., Nishita, M., Fukada, S-I., and Minami, Y.
    Critical role of Frizzled1 in age-related alterations of Wnt/β-catenin signal in myogenic cells during differentiation.
    Genes Cells 19 (4): 287-296, 2014.
  • Fukuyo, S., Yamaoka, K., Sonomoto, K., Oshita, K., Okada, Y., Saito, K., Yoshida, Y., Kanazawa, T., Minami, Y., and Tanaka, Y.
    IL-6-accelerated calcification by induction of Ror2 in human adipose tissue-derived mesenchymal stem cells is STAT3-dependent.
    Rheumatology 53(7):1282-1290,2014
  • Homma, Y., Kanno, S., Sasaki, K., Nishita, M., Yasui, A., Asano, T., Ohashi, K., and Mizuno, K.
    Insulin receptor substrate-4 binds to Slingshot-1 phosphatase and promotes cofilin dephosphorylation.
    J. Biol. Chem. 289: 26302-26313, 2014.


  • Li, X., Yamagata, K., Nishita, M., Endo, M., Arfian, N., Rikitake, Y., Emoto, N., Hirata, K., Tanaka, Y., and Minami, Y. Activation of Wnt5a-Ror2 signaling associated with epithelial-to-mesenchymal transition (EMT) of tubular epithelial cells during renal fibrosis.
    Genes Cells 18 (7)608-619, 2013
  • Hayashi M, Majumdar A, Li X, Adler J, Sun Z, Vertuani S, Hellberg C, Mellberg S, Koch S, Dimberg A, Koh GY, Dejana E, Belting H-G, Affolter M, Thurston G, Holmgren L, Vestweber D and Claesson-Welsh L.
    VE-PTP Regulates VEGFR2 Activity in Stalk Cells to Establish Endothelial Cell Polarity and Lumen Formation.
    Nature Communications 4: 1672 (2013)


  • Maeda, K., Kobayashi, Y., Udagawa, N., Uehara, S., Ishihara, A., Mizoguchi, T., Kikuchi, Y., Takada, I., Kato, S., Kani, S., Nishita, M., Marumo, K., Martin, T. J., Minami, Y., and Takahashi, N.
    Wnt5a-Ror2 signaling between osteoblasts and osteoclast precursors enhances osteoclastogenesis.
    Nat. Med., 18:405-412,2012
  • Endo, M., Doi, R., Nishita, M., and Minami, Y.
    Ror-family receptor tyrosine kinases regulate maintenance of neural progenitor cells in the developing neocortex.
    J. Cell Sci.,125: 2017-2029, 2012.
  • Yamagata, K., Li, X., Ikegaki, S., Oneyama, C., Okada, M., Nishita, M., and Minami, Y.
    Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase (MMP)-13 expression.
    J. Biol. Chem.287: 1588-1599, 2012.
  • Endo, M., Nishita, M., and Minami, Y.
    Analysis of Wnt/Planar cell polarity pathway in cultured cells.
    Methods Mol. Biol.839: 201-214, 2012.
  • Le Jan S, Hayashi M, Kasza Z, Eriksson I, Bishop JR, Weibrecht I, Heldin J, Holmborn K, Jakobsson L, Söderberg O, Spillmann D, Esko JD,
    Claesson-Welsh L, Kjellén L, and Kreuger J. Functional Overlap Between Chondroitin and Heparan Sulfate Proteoglycans During VEGF-Induced Sprouting Angiogenesis.
    Arteriosclerosis, Thrombosis, and Vascular Biology 32, no. 5: 1255-1263 (2012)


  • Takahashi, S., Watanabe, T., Okada, M., Inoue, K., Ueda, T., Takada, I., Watabe, T., Yamamoto, Y., Fukuda, T., Nakamura, T., Akimoto, C., Fujimura, T., Hoshino, M., Imai, Y., Metzger, D., Miyazono, K., Minami, Y., Chambon, P., Kitamura, T., Matsumoto, T., and Kato, S.
    Non-canonical Wnt signaling mediates androgen-dependent tumor growth in a mouse model of prostate cancer.
    Proc. Natl. Acad. Sci. USA, 2011. 108: 4938-4943,
  • Hagihara, M., Endo, M., Hata, K., Higuchi, C., Takaoka, K., Yoshikawa, H., and Yamashita, T.
    Neogenin, a receptor for bone morphogenetic proteins.
    J. Biol. Chem.2011. 286: 5157-5165,
  • Ren, D., Minami, Y.*, and Nishita, M.* (corresponding authors).
    Critical role of Wnt5a-Ror2 signaling in motility and invasiveness of epidermoid carcinoma cells following Snail-mediated epithelial-mesenchymal transition.
    Genes Cells, 2011.16: 304-315,
  • Gao, B., Song, H., Bishop, K., Eliott, G., Garrett, L., English, M. A., Andre, P., Robinson, J., Sood, R., Minami, Y., Economedes, A. N., and Yang, Y.
    Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2.
    Dev. Cell, 2011. 20: 163-176,


  • Lyashenko N, Weissenbock M, Sharir A, Erben R G, Minami Y, and Hartmann C.
    Mice lacking the orphan receptor Ror1 have distinct skeletal abnormalities and are growth retarded.
    Dev. Dyn., 2010. 239: 2266-2277,
  • Nishita M, Itsukushima S, Nomachi A, Endo M, Wang Z-C, Inaba D, Qiao S, Takada S, Kikuchi A, and Minami Y.
    Ror2/Frizzled complex mediates Wnt5a-induced AP-1 activation by regulating Dishevelled polymerization.
    Mol. Cell. Biol., 2010. Jul;30(14):3610-9
  • Nakagawa K, Sugahara M, Yamasak T, Kajiho H, Takahashi S, Hirayama J, Minami Y, Ohta Y, Watanabe T, Hata Y, Katada T, and Nishina H.
    Filamin associates with stress signaling kinase MKK7 and MKK4 and regulates JNK activation.
    Biochem. J.2010. 427: 237-245,
  • Yamada M, Udagawa J, Matsumoto A, Hashimoto R, Nishita M, Minami Y, and Otani H.
    Ror2 is required for midgut elongation during mouse development.
    Dev. Dyn.2010. 239 (3): 941-953,


  • Mikels A, Minami Y, and Nusse R,.
    The Ror2 receptor requires tyrosine kinase activity to mediate Wnt5a signaling.
  • Enomoto M, Hayakawa S, Itsukushima S, Dayong R, Matsuo M, Tamada K, Oneyama C, Okada M, Takumi T, Nishita M, Minami Y.
    Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a/Ror2 signaling.
    Oncogene, 2009.28: 3197-3208.
  • Endo M, Yamashita T.
    Inactivation of Ras by p120GAP via focal adhesion kinase dephosphorylation mediates RGMa-induced growth cone collapse.
    J Neurosci. 2009 May 20;29(20):6649-62.
  • Kobayashi M, Shibuya Y, Takeuchi J, Murata M, Suzuki H, Yokoo S, Umeda M, Minami Y, Komori T.
    Ror2 expression in squamous cell carcinoma and epithelial dysplasia of the oral cavity.
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Mar;107(3):398-406.
  • Mellberg S, Dimberg A, Bahram F, Hayashi M, Rennel E, Ameur A, Westholm JO, Larsson E, Lindahl P, Cross MJ, and Claesson-Welsh L.
    Transcriptional Profiling Reveals a Critical Role for Tyrosine Phosphatase VE-PTP in Regulation of VEGFR2 Activity and Endothelial Cell Morphogenesis.
    The FASEB Journal 23, no. 5: 1490-1502 (2009)
  • Takahata M, Inoue Y, Tsuda H, Imoto I, Koinuma D, Hayashi M, Ichikura T, Yamori T, Nagasaki K, Yoshida M, Matsuoka M, Morishita K, Yuki K, Hanyu A, Miyazawa K, Inazawa J, Miyazono K and Imamura T.
    SKI and MEL1 Cooperate to Inhibit Transforming Growth Factor-Beta Signal in Gastric Cancer Cells.
    The Journal of Biological Chemistry 284, no. 5: 3334-3344 (2009)