(KEYNOTE 1) Oct. 10, 2024 16:00～17:00
Akira Kikuchi, M.D.& Ph.D.
Specially Appointed Professor, Center for Infectious Disease Education and Research, Osaka University
Lessons from Experiments ~Lessons gained from my time at Kobe University School of Medicine～
After graduating from Kobe University School of Medicine in 1982, I began my career as a clinician in internal medicine before transitioning to Assistant Professor in the Department of Biochemistry in 1988. Since then, I have engaged in basic medical research at Kobe University, UC San Francisco, Hiroshima University, and Osaka University. Before establishing my own lab in 1995, my research focused on the modes of action and regulation of small GTP-binding proteins. After becoming independent, I embarked on a new research project concerning cellular functions and diseases mediated by Wnt signaling. The foundation of my research style was shaped by my experiences at Kobe University.
During these 40 years, technologies in various fields have advanced explosively. I recognize that the demands of scientific research have evolved significantly by shifts in political, economic, and social landscapes. Despite these changes, the fundamental desire of researchers—the curiosity to discover and the ambition to tackle new challenges—remains constant. In this lecture, I aim to discuss the evolution of researched on biology, life sciences, and medical sciences, and explore future directions. I would like to share insights gained through my own research journey with next generation researchers.
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(keynote 2) Oct. 10, 2024 17:10～18:10
Hiroshi Ohno, M.D & Ph. D.
RIKEN Center for Integrative Medical Sciences (IMS), Vice Director
Laboratory for Intestinal Ecosystem, Team Leader
Host-gut microbiota interaction
The intestinal tracts of animals, including humans,
contain more than 40 trillion intestinal microbiota.
The intestinal microbiota is closely related to our health
and diseases. Recent metagenomic analyses and studies
using sterile mice have revealed that dysbiosis,
an abnormal balance of the intestinal microbiota observed
in various diseases, is not the result of the disease
but rather the cause of its onset or exacerbation.
It is becoming clear that correcting this dysbiosis and
returning the balance to normal, i.e., symbiosis, is the key
to treatment and prevention.
We have attempted to understand the molecular mechanisms
of host-gut microbiota interactions using an integrated
omics approach that combines different levels of
comprehensive analysis, such as comprehensive gene expression
quantification (transcriptome) and metabolite
quantification (metabolome), in addition to
metagenomic analysis, which is comprehensive genome sequence
analysis. In this lecture,
I will explain how the intestinal microbiota is involved
in host defense, the immune system, and diseases.
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