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准教授 前濱 朝彦
Associate Professor Tomohiko Maehama

履  歴

出身/東京都

1990年3月
東京工業大学理学部生命理学科 卒業
1995年3月
東京工業大学大学院生命理学専攻 修了(理学博士号取得)
1995年4月
日本学術振興会PD特別研究員(東京大学薬学部 堅田利明教授)
1997年5月
ミシガン大学医学部リサーチフェロー(Jack E. Dixon教授)
2000年1月
東京都臨床医学総合研究所 薬理研究部門 研究員
2006年4月
国立感染症研究所 細胞化学部 細胞病態化学室 室長
○所属学会等/
日本生化学会,日本プロテインホスファターゼ研究会

原  著

  1. **Maehama T**, Kawahara K, Nishio M, Suzuki A, Hanada K. Nucleolar stress induces ubiquitination-independent proteasomal degradation of PICT1 protein. J Biol Chem. 2014 Jul 25;289(30):20802-12. PubMed PMID: 24923447; PubMed Central PMCID: PMC4110288.
  2. Kukimoto I, **Maehama T**, Sekizuka T, Ogasawara Y, Kondo K, Kusumoto-Matsuo R, Mori S, Ishii Y, Takeuchi T, Yamaji T, Takeuchi F, Hanada K, Kuroda M. Genetic variation of human papillomavirus type 16 in individual clinical specimens revealed by deep sequencing. PLoS One. 2013 Nov 13;8(11):e80583. doi: 10.1371/journal.pone.0080583. eCollection 2013. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/524fa93c-e77c-4c3d-bf6e-763a5b057409. PubMed PMID: 24236186; PubMed Central PMCID: PMC3827439.
  3. *Maehama T*, Fukasawa M, Date T, Wakita T, Hanada K. A class II phosphoinositide 3-kinase plays an indispensable role in hepatitis C virus replication. Biochem Biophys Res Commun. 2013 Oct 11;440(1):150-6. doi: 10.1016/j.bbrc.2013.09.048. Epub 2013 Sep 18. PubMed PMID: 24055031.
  4. Uchi R, Kogo R, Kawahara K, Sudo T, Yokobori T, Eguchi H, Sugimachi K, *Maehama T*, Mori M, Suzuki A, Komune S, Mimori K. PICT1 regulates TP53 via RPL11 and is involved in gastric cancer progression. Br J Cancer. 2013 Oct 15;109(8):2199-206. doi: 10.1038/bjc.2013.561. Epub 2013 Sep 17. PubMed PMID: 24045667; PubMed Central PMCID: PMC3798961.
  5. Sasaki M, Kawahara K, Nishio M, Mimori K, Kogo R, Hamada K, Itoh B, Wang J, Komatsu Y, Yang YR, Hikasa H, Horie Y, Yamashita T, Kamijo T, Zhang Y, Zhu Y, Prives C, Nakano T, Mak TW, Sasaki T, *Maehama T*, Mori M, Suzuki A. Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nat Med. 2011 Jul 31;17(8):944-51. doi: 10.1038/nm.2392. PubMed PMID: 21804542; PubMed Central PMCID: PMC4578312.
  6. Tanaka M, Hara H, Nishina H, Hanada K, Hagiwara K, *Maehama T*. An improved method for cell-to-cell transmission of infectious prion. Biochem Biophys Res Commun. 2010 Jul 2;397(3):505-8. doi: 10.1016/j.bbrc.2010.05.143. Epub 2010 May 31. PubMed PMID: 20515650.
  7. Malchinkhuu E, Sato K, *Maehama T*, Ishiuchi S, Yoshimoto Y, Mogi C, Kimura T, Kurose H, Tomura H, Okajima F. Role of Rap1B and tumor suppressor PTEN in the negative regulation of lysophosphatidic acid--induced migration by isoproterenol in glioma cells. Mol Biol Cell. 2009 Dec;20(24):5156-65. doi: 10.1091/mbc.E09-08-0692. Epub . PubMed PMID: 19864456; PubMed Central PMCID: PMC2793292.
  8. *Maehama T*, Tanaka M, Nishina H, Murakami M, Kanaho Y, Hanada K. RalA functions as an indispensable signal mediator for the nutrient-sensing system. J Biol Chem. 2008 Dec 12;283(50):35053-9. doi: 10.1074/jbc.M805822200. Epub 2008 Oct 23. PubMed PMID: 18948269; PubMed Central PMCID: PMC3259907.
  9. Malchinkhuu E, Sato K, *Maehama T*, Mogi C, Tomura H, Ishiuchi S, Yoshimoto Y, Kurose H, Okajima F. S1P(2) receptors mediate inhibition of glioma cell migration through Rho signaling pathways independent of PTEN. Biochem Biophys Res Commun. 2008 Feb 22;366(4):963-8. Epub 2007 Dec 26. PubMed PMID: 18088600.
  10. Okahara F, Itoh K, Nakagawara A, Murakami M, Kanaho Y, *Maehama T*. Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation. Mol Biol Cell. 2006 Nov;17(11):4888-95. Epub 2006 Sep 13. PubMed PMID: 16971513; PubMed Central PMCID: PMC1635402.
  11. Suzuki T, Kanai Y, Hara T, Sasaki J, Sasaki T, Kohara M, *Maehama T*, Taya C, Shitara H, Yonekawa H, Frohman MA, Yokozeki T, Kanaho Y. Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development. Mol Cell Biol. 2006 Aug;26(16):6149-56. PubMed PMID: 16880525; PubMed Central PMCID: PMC1592812.
  12. Nigorikawa K, Yoshikawa K, Sasaki T, Iida E, Tsukamoto M, Murakami H, *Maehama T*, Hazeki K, Hazeki O. A naphthoquinone derivative, shikonin, has insulin-like actions by inhibiting both phosphatase and tensin homolog deleted on chromosome 10 and tyrosine phosphatases. Mol Pharmacol. 2006 Sep;70(3):1143-9. Epub 2006 Jun 27. PubMed PMID: 16804092.
  13. Miyazaki H, Yamazaki M, Watanabe H, *Maehama T*, Yokozeki T, Kanaho Y. The small GTPase ADP-ribosylation factor 6 negatively regulates dendritic spine formation. FEBS Lett. 2005 Dec 19;579(30):6834-8. Epub 2005 Nov 28. PubMed PMID: 16325184.
  14. Sasaki J, Sasaki T, Yamazaki M, Matsuoka K, Taya C, Shitara H, Takasuga S, Nishio M, Mizuno K, Wada T, Miyazaki H, Watanabe H, Iizuka R, Kubo S, Murata S, Chiba T, *Maehama T*, Hamada K, Kishimoto H, Frohman MA, Tanaka K, Penninger JM, Yonekawa H, Suzuki A, Kanaho Y. Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}. J Exp Med. 2005 Mar 21;201(6):859-70. Epub 2005 Mar 14. PubMed PMID: 15767368; PubMed Central PMCID: PMC2213097.
  15. Okahara F, Itoh K, Ebihara M, Kobayashi M, Maruyama H, Kanaho Y, *Maehama T*. Production of research-grade antibody by in vivo electroporation of DNA-encoding target protein. Anal Biochem. 2005 Jan 1;336(1):138-40. PubMed PMID: 15582570.
  16. Okahara F, Ikawa H, Kanaho Y, *Maehama T*. Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein. J Biol Chem. 2004 Oct 29;279(44):45300-3. Epub 2004 Sep 7. PubMed PMID: 15355975.
  17. Watanabe H, Yokozeki T, Yamazaki M, Miyazaki H, Sasaki T, *Maehama T*, Itoh K, Frohman MA, Kanaho Y. Essential role for phospholipase D2 activation downstream of ERK MAP kinase in nerve growth factor-stimulated neurite outgrowth from PC12 cells. J Biol Chem. 2004 Sep 3;279(36):37870-7. Epub 2004 Jun 29. PubMed PMID: 15226317.
  18. *Maehama T*, Kosaka N, Okahara F, Takeuchi K, Umeda M, Dixon JE, Kanaho Y. Suppression of a phosphatidylinositol 3-kinase signal by a specific spliced variant of Drosophila PTEN. FEBS Lett. 2004 May 7;565(1-3):43-7. PubMed PMID: 15135050.
  19. Watanabe H, Yamazaki M, Miyazaki H, Arikawa C, Itoh K, Sasaki T, *Maehama T*, Frohman MA, Kanaho Y. Phospholipase D2 functions as a downstream signaling molecule of MAP kinase pathway in L1-stimulated neurite outgrowth of cerebellar granule neurons. J Neurochem. 2004 Apr;89(1):142-51. PubMed PMID: 15030398.
  20. Merlot S, Meili R, Pagliarini DJ, *Maehama T*, Dixon JE, Firtel RA. A PTEN-related 5-phosphatidylinositol phosphatase localized in the Golgi. J Biol Chem. 2003 Oct 10;278(41):39866-73. Epub 2003 Jul 23. PubMed PMID: 12878591.
  21. Nogami M, Yamazaki M, Watanabe H, Okabayashi Y, Kido Y, Kasuga M, Sasaki T, *Maehama T*, Kanaho Y. Requirement of autophosphorylated tyrosine 992 of EGF receptor and its docking protein phospholipase C gamma 1 for membrane ruffle formation. FEBS Lett. 2003 Feb 11;536(1-3):71-6. PubMed PMID: 12586341.
  22. Yamazaki M, Miyazaki H, Watanabe H, Sasaki T, *Maehama T*, Frohman MA, Kanaho Y. Phosphatidylinositol 4-phosphate 5-kinase is essential for ROCK-mediated neurite remodeling. J Biol Chem. 2002 May 10;277(19):17226-30. Epub 2002 Feb 27. PubMed PMID: 11877391.
  23. Gustin JA, *Maehama T*, Dixon JE, Donner DB. The PTEN tumor suppressor protein inhibits tumor necrosis factor-induced nuclear factor kappa B activity. J Biol Chem. 2001 Jul 20;276(29):27740-4. Epub 2001 May 16. PubMed PMID: 11356844.
  24. Ozes ON, Akca H, Mayo LD, Gustin JA, *Maehama T*, Dixon JE, Donner DB. A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4640-5. Epub 2001 Apr 3. PubMed PMID: 11287630; PubMed Central PMCID: PMC31887.
  25. Taylor GS, *Maehama T*, Dixon JE. Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate. Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8910-5. PubMed PMID: 10900271; PubMed Central PMCID: PMC16795.
  26. Clemens JC, Worby CA, Simonson-Leff N, Muda M, *Maehama T*, Hemmings BA, Dixon JE. Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6499-503. PubMed PMID: 10823906; PubMed Central PMCID: PMC18635.
  27. *Maehama T*, Taylor GS, Slama JT, Dixon JE. A sensitive assay for phosphoinositide phosphatases. Anal Biochem. 2000 Mar 15;279(2):248-50. PubMed PMID: 10706796.
  28. Ignatoski KM, *Maehama T*, Markwart SM, Dixon JE, Livant DL, Ethier SP. ERBB-2 overexpression confers PI 3' kinase-dependent invasion capacity on human mammary epithelial cells. Br J Cancer. 2000 Feb;82(3):666-74. PubMed PMID: 10682681; PubMed Central PMCID: PMC2363331.
  29. Lee JO, Yang H, Georgescu MM, Di Cristofano A, *Maehama T*, Shi Y, Dixon JE, Pandolfi P, Pavletich NP. Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell. 1999 Oct 29;99(3):323-34. PubMed PMID: 10555148.
  30. Sasaki T, *Maehama T*, Yamamoto T, Takasuga S, Hoshino S, Nishina H, Hazeki O, Katada T. Activation of c-Jun N-terminal kinase (JNK) by lysophosphatidic acid in Swiss 3T3 fibroblasts. J Biochem. 1998 Nov;124(5):934-9. PubMed PMID: 9792916.
  31. *Maehama T*, Dixon JE. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem. 1998 May 29;273(22):13375-8. PubMed PMID: 9593664.
  32. Kurosu H, *Maehama T*, Okada T, Yamamoto T, Hoshino S, Fukui Y, Ui M, Hazeki O, Katada T. Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110beta is synergistically activated by the betagamma subunits of G proteins and phosphotyrosyl peptide. J Biol Chem. 1997 Sep 26;272(39):24252-6. PubMed PMID: 9305878.
  33. *Maehama T*, Hoshino S, Katada T. Increase in ADP-ribosyltransferase activity of rat T lymphocyte alloantigen RT6.1 by a single amino acid mutation. FEBS Lett. 1996 Jun 17;388(2-3):189-91. PubMed PMID: 8690084.
  34. Nishina H, Nimota K, Kukimoto I, *Maehama T*, Takahashi K, Hoshino S, Kanaho Y, Katada T. Significance of Thr182 in the nucleotide-exchange and GTP-hydrolysis reactions of the alpha subunit of GTP-binding protein Gi2. J Biochem. 1995 Nov;118(5):1083-9. PubMed PMID: 8749330.
  35. *Maehama T*, Nishina H, Hoshino S, Kanaho Y, Katada T. NAD(+)-dependent ADP-ribosylation of T lymphocyte alloantigen RT6.1 reversibly proceeding in intact rat lymphocytes. J Biol Chem. 1995 Sep 29;270(39):22747-51. PubMed PMID: 7559400.
  36. *Maehama T*, Nishina H, Katada T. ADP-ribosylarginine glycohydrolase catalyzing the release of ADP-ribose from the cholera toxin-modified alpha-subunits of GTP-binding proteins. J Biochem. 1994 Nov;116(5):1134-8. PubMed PMID: 7896743.
  37. *Maehama T*, Sekine N, Nishina H, Takahashi K, Katada T. Characterization of botulinum C3-catalyzed ADP-ribosylation of rho proteins and identification of mammalian C3-like ADP-ribosyltransferase. Mol Cell Biochem. 1994 Sep;138(1-2):135-40. PubMed PMID: 7898456.
  38. *Maehama T*, Takahashi K, Ohoka Y, Ohtsuka T, Ui M, Katada T. Identification of a botulinum C3-like enzyme in bovine brain that catalyzes ADP-ribosylation of GTP-binding proteins. J Biol Chem. 1991 Jun 5;266(16):10062-5. PubMed PMID: 1645335.
  39. Ohoka Y, Imai S, Kozasa T, *Maehama T*, Takahashi K, Kaziro Y, Ui M, Katada T. Purification and characterization of a new GTP-binding protein of Mr 24,000 in bovine brain membranes. J Biochem. 1991 Mar;109(3):428-35. PubMed PMID: 1908860.
  40. *Maehama T*, Ohoka Y, Ohtsuka T, Takahashi K, Nagata K, Nozawa Y, Ueno K, Ui M, Katada T. Botulinum ADP-ribosyltransferase activity as affected by detergents and phospholipids. FEBS Lett. 1990 Apr 24;263(2):376-80. PubMed PMID: 2110536.

総  説

  1. 後藤裕樹,西尾美希,加藤雅子,*前濱朝彦*,鈴木聡:機械的刺激によるHippo-YAP/TAZ経路の活性化,生理作用,腫瘍進展メカニズムと意義.生体の科学 67, 127-131, 2016
  2. *前濱朝彦*,鈴木聡:PTEN.日本臨牀(増刊) 73, 285-290, 2015
  3. *前濱朝彦*,鈴木聡:PTEN:脂質ホスファターゼとしての機能と発がんへの関与.実験医学(増刊) 33, 157-163, 2015
  4. *前濱朝彦*,鈴木聡:PTEN/PI3Kシグナルと発がん.The Lipid 25, 391-397, 2014
  5. Nishio M, Otsubo K, *Maehama T*, Mimori K, Suzuki A. Capturing the mammalian Hippo: elucidating its role in cancer. Cancer Sci. 2013 Oct;104(10):1271-7. doi: 10.1111/cas.12227. Epub 2013 Aug 7. PubMed PMID: 23829894.
  6. 西尾美希,河原康一,佐々木雅人,*前濱朝彦*,佐々木雄彦,三森功士,森正樹,鈴木聡:核小体を起点としp53を制御する新規分子PICT1による細胞増殖制御機構.実験医学(増刊) 31, 127-134, 2013
  7. Suzuki A, Kogo R, Kawahara K, Sasaki M, Nishio M, *Maehama T*, Sasaki T, Mimori K, Mori M. A new PICTure of nucleolar stress. Cancer Sci. 2012 Apr;103(4):632-7. doi: 10.1111/j.1349-7006.2012.02219.x. Epub 2012 Mar 8. Review. PubMed PMID: 22320853.
  8. *前濱朝彦*:アミノ酸感知シグナル.細胞工学 28, 760-764, 2009
  9. *前濱朝彦*:アミノ酸感知シグナル-mTOR活性化の分子機構-.アミノ酸研究 3, 5-14, 2009
  10. *前濱朝彦*,岡原史明,金保安則:あらたな癌抑制遺伝子PICT-1/GLTSCR2.医学のあゆみ 224, 172-173, 2008
  11. *Maehama T*. PTEN: its deregulation and tumorigenesis. Biol Pharm Bull. 2007 Sep;30(9):1624-7. Review. PubMed PMID: 17827710.
  12. *前濱朝彦*:リン脂質ホスファターゼPTENの新しい活性調節機構.生化学 78, 133-137, 2006
  13. *Maehama T*, Okahara F, Kanaho Y. The tumour suppressor PTEN: involvement of a tumour suppressor candidate protein in PTEN turnover. Biochem Soc Trans. 2004 Apr;32(Pt 2):343-7. Review. PubMed PMID: 15046605.
  14. *Maehama T*, Taylor GS, Dixon JE. PTEN and myotubularin: novel phosphoinositide phosphatases. Annu Rev Biochem. 2001;70:247-79. Review. PubMed PMID: 11395408.
  15. *前濱朝彦*,Jack E. Dixon:PTENのリン脂質フォスファターゼとしての機能.細胞工学 19, 751-753, 2000
  16. *前濱朝彦*:脂質ホスファターゼとしてのがん抑制遺伝子産物PTEN.ファルマシア 36, 854-858, 2000
  17. *前濱朝彦*,Jack E. Dixon:癌抑制遺伝子PTEN.蛋白質核酸酵素 45, 2405-2414, 2000
  18. *Maehama T*, Dixon JE. PTEN: a tumour suppressor that functions as a phospholipid phosphatase. Trends Cell Biol. 1999 Apr;9(4):125-8. Review. PubMed PMID: 10203785.
  19. *Maehama T*, Katada T. Molecular characterization of rat T lymphocyte alloantigen RT6.1 as an ADP-ribosyltransferase. Adv Exp Med Biol. 1997;419:181-3. PubMed PMID: 9193652.
  20. 堅田利明,仁科博史,高橋勝宣,星野真一,紺谷圏二,*前濱朝彦*,柊元巌:シグナル伝達系に登場した新しいNAD+代謝酵素.蛋白質核酸酵素 40, 1900-1911, 1995
  21. *前濱朝彦*,高橋勝宣,堅田利明:ARFと新しいボツリヌスC3酵素反応促進因子.実験医学 8, 214-217, 1990

シンポジウム・海外発表

国際学会における発表(シンポジウム)

  1. *Maehama T*: Identification of a Ras-family GTPase as an indispensable signal mediator for nutrient sensing and mTORC1 activation. 8th International Conference on Protein Phosphatases, November 2008
  2. *Maehama T*: PICT-1: a PTEN regulator involved in tumorigenesis. 2nd International Symposium of the 21st COE Program, Akita Univ. School of Medicine, June 2006
  3. *Maehama T*, Okahara F, Kanaho Y: The tumour suppressor PTEN: involvement of a tumour suppressor candidate in the PTEN turnover. Biochemical Society Focused Meeting "PI 3-kinase in Signalling and Disease", November 2003
  4. *Maehama T*, Okahara F, Kanaho Y: Turnover control of PTEN by a tumor suppressor. 2nd Japan-Korea Conference on Cellular Signaling, July 2003
  5. *Maehama T*: A novel tumor suppressor candidate interacting with the lipid phosphatase PTEN. 1st Korea-Japan Conference on Signal Transduction, July 2002
  6. *Maehama T*, Ikawa H, Kanaho Y: A novel tumor suppressor candidate interacting with the lipid phosphatase PTEN. 5th International Conference on Protein Phosphatases, March 2002
  7. *Maehama T*: PTEN functions as a lipid phosphatase. 4th International Conference on Protein Phosphatases, November 2000
  8. *Maehama T*, Dixon JE: PTEN: a tumour suppressor that functions as a phosphatidylinositol phosphatase. EMBO Conference - FEBS Advanced Course on "Protein Phosphorylation and Protein Phosphatases", September 1999

国際学会における発表(口演・ポスター)

  1. *Maehama T*, Nishio M, Kawahara K, Suzuki A: Nucleolar stress induces ubiquitination-independent proteasomal degradation of PICT1 protein. 11th International Conference of Protein Phosphatase, November 2014
  2. Kusumoto-Matsuo R, Mori S, *Maehama T*, Kukimoto I: Wee1 binds to and stabilizes the E1 helicase of human papillomavirus type 16. 29th International Papillomavirus Conference, August 2014
  3. *Maehama T*, Kawahara K, Nishio M, Suzuki A: Nucleolar stress induces ubiquitin-independent proteasomal degradation of PICT1. 10th International Conference of Protein Phosphatase, February 2013
  4. Kukimoto I, *Maehama T*, Mori S, Kusumoto-Matsuo R, Kondo K, Sekizuka T, Kuroda M: A novel method to determine the full-genome sequence of human papillomavirus type 16 using full-circle PCR followed by deep sequencing. 28th International Papillomavirus Conference, November 2012
  5. Ito G, Ariga H, Nakagawa Y, Miyagishi M, Taira K, *Maehama T*, Iwatsubo T: Molecular and cell biological analysis of the function of DJ-1, a causative gene for PARK7. Society for Neuroscience 35th Annual Meeting, November 2005
  6. Okahara F, Itoh K, Kanaho Y, *Maehama T*: A candidate tumor suppressor PTEN-binding protein. 3rd Korea-Japan Conference on Cellular Signaling, July 2004
  7. *Maehama T*, Ikawa H, Kanaho Y: Interaction of the PTEN lipid phosphatase with a candidate tumor suppressor gene product. 11th International Conference on Second Messengers & Phosphoproteins, April 2001
  8. *Maehama T*, Stuckey J, Dixon JE: Critical role of lysine-125/128 in inositol phosphatase activity of PTEN. Cold Spring Harbor Laboratory Meeting on "Tyrosine Phosphorylation & Cell Signalling", May1999
  9. *Maehama T*, Katada T: Molecular characterization of rat T lymphocyte alloantigen RT6.1 as an ADP-ribosyltransferase. Biological Significance of Mono-ADP-Ribosylation in Animal Tissues, May 1996
  10. *Maehama T*, Nishina H, Hoshino S, Kanaho Y, Katada T: NAD+-dependent ADP-ribosylation of T-lymphocyte alloantigen RT6.1 reversibly proceeding in intact rat lymphocytes. 9th International Conference on Second Messengers & Phosphoproteins, October 1995

国内学会における発表(シンポジウム・招待講演)

  1. *前濱朝彦*:mTORC1活性制御機構-細胞がアミノ酸を感知する仕組み,つくば分子生命科学セミナー,2012年3月(招待講演)
  2. *前濱朝彦*:アミノ酸感知シグナル-mTOR活性化の分子機構,日本アミノ酸学会 第3回夏のシンポジウム,2009年7月(シンポジウム)
  3. *前濱朝彦*:細胞の栄養素感知システムに関わるGサイクル制御因子,Gタンパク質特定領域・膜輸送複合体特定領域 合同若手ワークショップ 2009,2009年1月(シンポジウム)
  4. *前濱朝彦*:アミノ酸センシングの細胞内シグナル-Rheb-TOR活性化機構-,味の素(株)医薬研究所セミナー,2007年5月(招待講演)
  5. *前濱朝彦*:PTEN制御因子PICT-1による発がん制御,群馬大学21世紀COE若手研究者シンポジウム,2006年10月(シンポジウム)
  6. *前濱朝彦*:癌抑制遺伝子PTEN - その制御機構と病態,生理学研究所所長招聘セミナー,2005年8月(招待講演)
  7. *前濱朝彦*:PICT-1による癌抑制遺伝子産物PTENの制御,第125年会日本薬学会,2005年3月(シンポジウム)
  8. *前濱朝彦*,金保安則:脂質ホスファターゼPTENのC末端領域の機能解析:C末端領域欠失による"loss-of-function"メカニズムの解明,第75回日本生化学会大会シンポジウム 「プロテインホスファターゼ研究の新展開」,2002年11月(シンポジウム)
  9. *前濱朝彦*:癌抑制遺伝子産物PTENの脂質ホスファターゼとしての機能,文部科学省科学研究費特定領域(B)公開シンポジウム「高等動物ホスホリパーゼの新しい機能」,2002年1月(招待講演)

国内学会における発表(口演・ポスター)

  1. 渡邊菜月,野崎智義,*前濱朝彦*,津久井久美子:赤痢アメーバにおけるホスファチジルイノシトールシグナルの解析,第57回日本脂質生化学会,2015.5.28-29,東京
  2. 河原康一,堀口史人,上條陽平,山本雅達,新里能成,南謙太朗,エフ・エム・モイヌディン,有馬一成,西尾美希,佐々木雅人,*前濱朝彦*,鈴木聡,古川龍彦:生体イメージング技術による核小体ストレス応答の制御基盤の解明,第87回日本生化学会大会,2014.10.15-18,京都
  3. *前濱朝彦*,河原康一,西尾美希,鈴木聡,花田賢太郎:核小体ストレスに応答した癌制御因子PICT1のプロテアソーム依存性・ユビキチン非依存性分解,第86回日本生化学会大会,2013.9.11-13,横浜
  4. 松尾理加,森清一郎,*前濱朝彦*,柊元巌:ヒトパピローマウイルス16型 E1タンパク質に結合する細胞チロシンキナーゼの同定,第61回日本ウイルス学会学術集会,2013.11.10-12,神戸
  5. *前濱朝彦*,西尾美希,鈴木聡:核小体ストレスに応答した癌制御因子PICT1のプロテアソーム依存性・ユビキチン非依存性分解,第6回日本プロテインホスファターゼ研究会学術集会,2014.2.10-21,津
  6. 柊元巌,*前濱朝彦*,松尾理加,関塚剛史,黒田誠:次世代シークエンサーによるHPV16ゲノム解析,第60回二本ウイルス学会学術集会,2012.11.13-15,大阪
  7. *前濱朝彦*:mTORC1制御に関与するGタンパク質群の解析,第84回日本生化学会大会,2012.12.14-16,福岡
  8. *前濱朝彦*,深澤征義,伊達朋子,脇田隆字,花田賢太郎:イノシトールリン脂質によるC型肝炎ウイルス増殖の制御,第83回日本生化学会大会,2011.9.21-24,京都
  9. 河原康一,佐々木雅人,西尾美希,古後龍之介,三森功士,濱田浩一,伊東文祥,佐々木雄彦,*前濱朝彦*,森正樹,鈴木聡:p53の制御に関わる新規腫瘍関連遺伝子の同定,第69回日本癌学会学術総会,2010.9.22-24,大阪
  10. *前濱朝彦*:mTORC1制御に関与するGタンパク質群の解析,第33回日本分子生物学会年会・第83回日本生化学会合同大会,2010.12.7-10,神戸
  11. *前濱朝彦*:アミノ酸感知シグナル-mTOR活性化の分子機構-,日本アミノ酸学会第3回夏のシンポジウム,2009.7.19,筑紫野
  12. 田中正彦,原英之,萩原健一,花田賢太郎,仁科博史,*前濱朝彦*:共培養系を用いた高効率なPrPSc伝播実験系の確立,第82回日本生化学会大会,2009.10.21-24,神戸
  13. 西尾美希,河原康一,佐々木雅人,*前濱朝彦*,佐々木雄彦,鈴木聡:PTEN結合分子PICT1のT細胞分化における機能解析,第71回日本血液学会総会,2009.10.23-25,京都
  14. *前濱朝彦*:細胞外環境の変化に応答したmTORC1活性調節機構の解析,第4回日本プロテインホスファターゼ研究会学術集会,2009.11.13-14,熊本
  15. *前濱朝彦*:mTORC1活性化の分子機構-アミノ酸感知シグナル-,第32回日本分子生物学会年会,2009.12.9-12,横浜
  16. *前濱朝彦*,花田賢太郎:mTOR活性化シグナルにおけるイノシトールリン脂質群の関与,第3回日本プロテインホスファターゼ研究会学術集会,2007.3
  17. 佐々木雅人,濱田浩一,河原康一,佐々木雄彦,*前濱朝彦*,鈴木聡:PICT-1によるPTEN制御機構とその生理機能の解析,第65回癌学会総会,2006.9
  18. 岡原史明,伊藤康一,金保安則,*前濱朝彦*:癌抑制遺伝子産物PTENの制御因子PICT-1による発癌制御機構の解析,第28回日本分子生物学会大会,2005.11
  19. Suzuki T, Kanai Y, Hara T, Sasaki J, Sasaki T, Kohara M, Yokozeki T, *Maehama T*, Kanaho Y:ARF6 is required for hepatic cord formation and liver development,第78回日本生化学会大会,2005.10
  20. *前濱朝彦*,岡原史明,金保安則:PTEN制御因子PICT-1による細胞増殖制御,第2回プロテインホスファターゼ研究会学術集会,2005.8
  21. 岡原史明,金保安則,*前濱朝彦*:A role for PICT-1, a PTEN-binding protein, in cell proliferation and transformation,第58回日本細胞生物学会大会,2005.6
  22. Okahara F, Itoh K, Kanaho Y, *Maehama T*:A convenient method for antibody production: application of in vivo electroporation,第77回日本生化学会大会,2004.10
  23. *Maehama T*, Okahara F, Kanaho Y:A candidate tumor suppressor regulates PTEN phosphorylation and turnover,第77回日本生化学会大会,2004.10
  24. Kosaka N, Okahara F, Kanaho Y, *Maehama T*:Biochemical characterization of Drosophila PTEN,第76回日本生化学会大会,2003.10
  25. *前濱朝彦*,岡原史明,金保安則:脂質ホスファターゼPTENのターンオーバー制御,第1回プロテインホスファターゼ研究会学術集会,2003.7
  26. 小坂夏紀,金保安則,*前濱朝彦*:ショウジョウバエPTENの生化学的解析,ファーマ・バイオフォーラム2002,2002.11
  27. 伊川英樹,金保安則,*前濱朝彦*:PTENと相互作用する癌抑制遺伝子産物,第74回日本生化学会大会,2001.10
  28. *前濱朝彦*,星野真一,堅田利明:部位特異的変異導入によるラットアロ抗原RT6.1のADPリボシル化活性の上昇,第69回日本生化学会大会,1996.10
  29. *前濱朝彦*,仁科博史,星野真一,金保安則,堅田利明:ラットリンパ球アロ抗原RT6.1のADPリボシル化反応,第68回日本生化学会大会,1995.10
  30. *前濱朝彦*,仁科博史,稲毛田清,高橋勝宣,堅田利明:ADPリボシル化GTP結合蛋白質を基質とするグリコヒドロラーゼの特性,第66回日本生化学会大会,1993.10
  31. *前濱朝彦*,大塚智一,大岡嘉治,高橋勝宣,宇井理生,堅田利明:ボツリヌス菌由来のC3酵素に類似した内在性ADPリボシル化酵素,第63回日本生化学会大会,1990.9
  32. 前濱朝彦*,大岡嘉治,大塚智一,高橋勝宣,永田浩一,野澤義則,上野一恵,宇井理生,堅田利明:ボツリヌス菌由来の酵素(C3)が触媒するADP-リボシル化反応,第62回日本生化学会大会,1989.11
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