学位取得者

2020年度

藤川 正隆

Chemokine (C-C Motif) Ligand 1 Derived from Tumor-Associated Macrophages Contributes to Esophageal Squamous Cell Carcinoma Progression via CCR8-Mediated Akt/Proline-Rich Akt Substrate of 40 kDa/Mammalian Target of Rapamycin Pathway
Masataka Fujikawa, Yu-ichiro Koma, Masayoshi Hosono, Naoki Urakawa, Kohei Tanigawa, Masaki Shimizu, Takayuki Kodama, Hiroki Sakamoto, Mari Nishio, Manabu Shigeoka, Yoshihiro Kakeji and Hiroshi Yokozaki
The American Journal of Pathology 2021 Apr;191(4):686-703.  doi: 10.1016/j.ajpath.2021.01.004

坂本 浩輝

PAI-1 derived from cancer-associated fibroblasts in esophageal squamous cell carcinoma promotes the invasion of cancer cells and the migration of macrophages
Hiroki Sakamoto, Yu-Ichiro Koma, Nobuhide Higashino, Takayuki Kodama, Kohei Tanigawa, Masaki Shimizu, Masataka Fujikawa, Mari Nishio, Manabu Shigeoka, Yoshihiro Kakeji and Hiroshi Yokozaki
Laboratory Investigation 2021 Mar;101(3):353-368.  doi: 10.1038/s41374-020-00512-2.

杉田 裕

CD244+ polymorphonuclear myeloid-derived suppressor cells reflect the status of peritoneal dissemination in colon cancer mouse model
Yutaka Sugita, Kimihiro Yamashita, Mitsugu Fujita, Masafumi Saito, Kota Yamada, Kyosuke Agawa, Akihiro Watanabe, Eiji Fukuoka, Hiroshi Hasegawa, Shingo Kanaji, Taro Oshikiri, Takeru Matsuda, Tetsu Nakamura, Satoshi Suzuki and Yoshihiro Kakeji
Oncology Reports 2021 Jun; 45(6): 106.  doi: 10.3892/or.2021.8057.

石田 苑子

Neuroendocrine carcinoma and mixed neuroendocrine‒non-neuroendocrine neoplasm of the stomach: a clinicopathological and exome sequencing study
Sonoko Ishida, Masayuki Akita, Kohei Fujikura, Masato Komatsu, Ryuichiro Sawada, Hisayuki Matsumoto, Jun Saegusa, Tomoo Itoh, Yoshihiro Kakeji and Yoh Zen
Human Pathology 2021 Apr;110:1-10.  doi: 10.1016/j.humpath.2020.12.008.

永田 真知子

Usefulness of Omentoplasty to Reduce Perineal Wound Complications in Abdominoperineal Resection After Neoadjuvant Chemoradiotherapy
Machiko Nagata, Takeru Matsuda, Hiroshi Hasegawa, Masako Utsumi, Kimihiro Yamashita, Masashi Yamamoto, Shingo Kanaji, Taro Oshikiri, Tetsu Nakamura, Satoshi Suzuki and Yoshihiro Kakeji
Anticancer Research Nov 2020, 40 (11) 6539-6543.  doi:10.21873/anticanres.14678

小寺澤 康文

Retinoic acid receptor γ activation promotes differentiation of human induced pluripotent stem cells into esophageal epithelium
Yasufumi Koterazawa, Michiyo Koyanagi-Aoi, Keiichiro Uehara, Yoshihiro Kakeji, Takashi Aoi
Journal of Gastroenterology 2020 Aug;55(8):763-774.  doi: 10.1007/s00535-020-01695-7.

山崎 悠太

Automated Surgical Instrument Detection from Laparoscopic Gastrectomy Video Images Using an Open Source Convolutional Neural Network Platform
Yuta Yamazaki, Shingo Kanaji, Takeru Matsuda, Taro Oshikiri, Tetsu Nakamura, Satoshi Suzuki, Yuta Hiasa, Yoshito Otake, Yoshinobu Sato, Yoshihiro Kakeji
Journal of the American College of Surgeons 2020 May;230(5):725-732.e1.  doi: 10.1016/j.jamcollsurg.2020.01.037.

2019年度

池田 太郎

Mesenchymal stem cell-derived CXCL16 promotes progression of gastric cancer cells by STAT3-mediated expression of Ror1
Taro Ikeda, Michiru Nishita, Kyoka Hoshi, Takashi Honda, Yoshihiro Kakeji, Yasuhiro Minami
Cancer Science 2020 Apr;111(4):1254-1265.  doi: 10.1111/cas.14339.

福岡 英志

Neoadjuvant Chemotherapy Increases PD-L1 Expression and CD8+Tumor-infiltrating Lymphocytes in Esophageal Squamous Cell Carcinoma
Eiji Fukuoka, Kimihiro Yamashita, Tomoko Tanaka, Ryuichiro Sawada,Yutaka Sugita, Akira Arimoto, Mitsugu Fujita, Gosuke Takiguchi, Takeru Matsuda, Taro Oshikiri, Tetsu Nakamura, Satoshi Suzuki, Yoshihiro Kakeji
Anticancer Research 2019 Aug;39(8):4539-4548.  doi: 10.21873/anticanres.13631.

2018年度

田中 智子

Frequency of Myeloid-derived Suppressor Cells in the Peripheral Blood Reflects the Status of Tumor Recurrence
Tomoko Tanaka, Mitsugu Fujita, Hiroshi Hasegawa, Akira Arimoto, Masayasu Nishi, Eiji Fukuoka, Yutaka Sugita, Takeru Matsuda, Yasuo Sumi, Satoshi Suzuki, Yoshihiro Kakeji, Kimihiro Yamashita
Anticancer Research 2017 Jul;37(7):3863-3869.  doi: 10.21873/anticanres.11766.

有本 聡

Immunosuppression Induced by Perioperative Peritonitis Promotes Lung Metastasis
Akira Arimoto, Kimihiro Yamashita, Hiroshi Hasegawa, Yutaka Sugita, Eiji Fukuoka, Tomoko Tanaka, Satoshi Suzuki, Yoshihiro Kakeji
Anticancer Res. 2018 Jul;38(7):4333-4338.  doi: 10.21873/anticanres.12733.

植田 康司

PROX1 Is Associated with Cancer Progression and Prognosis in Gastric Cancer
Koji Ueta, Yasunori Otowa, Yoshihiro Kakeji , Masanori Hirashima
Anticancer Research 2018 Nov;38(11):6139-6145.  doi: 10.21873/anticanres.12966.

東野 展英

Fibroblast activation protein-positive fibroblasts promote tumor progression through secretion of CCL2 and interleukin-6 in esophageal squamous cell carcinoma
Nobuhide Higashino, Yu-Ichiro Koma, Masayoshi Hosono, Nobuhisa Takase, Maiko Okamoto, Himiko Kodaira, Mari Nishio, Manabu Shigeoka, Yoshihiro Kakeji, Hiroshi Yokozaki
Laboratory Investigation 2019 Jun;99(6):777-792.  doi: 10.1038/s41374-018-0185-6.

青木 丈明

Intraflagellar transport 20 promotes collective cancer cell invasion by regulating polarized organization of Golgi-associated microtubules
Tomoaki Aoki, Michiru Nishita, Junya Sonoda, Taro Ikeda, Yoshihiro Kakeji, Yasuhiro Minami
Cancer Science 2019 Apr;110(4):1306-1316.  doi: 10.1111/cas.13970.

澤田 隆一郎

Interleukin-33 overexpression reflects less aggressive tumour features in large-duct type cholangiocarcinomas
Ryuichiro Sawada, Yuna Ku, Masayuki Akita, Kyoko Otani, Kohei Fujikura, Tomoo Itoh, Tetsuo Ajiki, Takumi Fukumoto, Yoshihiro Kakeji, Yoh Zen
Histopathology. 2018 Aug;73(2):259-272.  doi: 10.1111/his.13633.

2017年度

秋山 真吾

Prognostic impact of MutT homolog-1 expression on esophageal squamous cell carcinoma
Shingo Akiyama, Hiroshi Saeki, Yuichiro Nakashima, Makoto Iimori, Hiroyuki Kitao, Eiji Oki, Yoshinao Oda, Yusaku Nakabeppu, Yoshihiro Kakeji, Yoshihiko Maehara
Cancer Medicine. 2017 Jan; 6(1): 258-266.  doi: 10.1002/cam4.979.

石田 諒

The Tissue-Reconstructing Ability of Colon CSCs Is Enhanced by FK506 and Suppressed by GSK3 Inhibition
Ryo Ishida, Michiyo Koyanagi-Aoi, Nobu Oshima, Yoshihiro Kakeji, Takashi Aoi
Mol Cancer Res. 2017 Oct;15(10):1455-1466.  doi: 10.1158/1541-7786.MCR-17-0071.

前原 律子

SOX2-silenced squamous cell carcinoma: A highly malignant form of esophageal cancer with SOX2 promoter hypermethylation
Ritsuko Maehara, Kohei Fujikura, Kengo Takeuchi, Masayuki Akita, Shiho Abe-Suzuki, Jana Karbanová, Denis Corbeil, Tomoo Itoh, Yoshihiro Kakeji, Yoh Zen
Modern Pathology. 2018 Jan;31(1):83-92.  doi: 10.1038/modpathol.2017.112.

中川 暁雄

The Surgical Apgar Score Predicts Not Only Short-Term Complications But Also Long-Term Prognosis After Esophagectomy
Akio Nakagawa, Tetsu Nakamura, Taro Oshikiri, Hiroshi Hasegawa, Masashi Yamamoto, Shingo Kanaji, Yoshiko Matsuda, Kimihiro Yamashita, Takeru Matsuda, Yasuo Sumi, Satoshi Suzuki, Yoshihiro Kakeji
Annals of Surgical Oncology 2017 Dec;24(13):3934-3946.  doi: 10.1245/s10434-017-6103-0.

細野 雅義

CXCL8 derived from tumor-associated macrophages and esophageal squamous cell carcinomas contributes to tumor progression by promoting migration and invasion of cancer cells
Masayoshi Hosono, Yu-ichiro Koma, Nobuhisa Takase, Naoki Urakawa, Nobuhide Higashino, Kazuki Suemune, Himiko Kodaira, Mari Nishio, Manabu Shigeoka, Yoshihiro Kakeji and Hiroshi Yokozaki
Oncotarget. 2017 Nov 20;8(62):106071-106088.  doi: 10.18632/oncotarget.22526.

多田羅 敬

Expression of programmed death-1 in sentinel lymph nodes of breast cancer
Takashi Tatara, Toru Mukohara, Yohei Shimono, Takashi Yamazaki, Yoshinori Imamura, Yohei Funakoshi, Masanori Toyoda, Naomi Kiyota, Seishi Kono, Shintaro Takao, Yoshihiro Kakeji, Hironobu Minami
Journal of Surgical Oncology 2018 May;117(6):1131-1136.  doi: 10.1002/jso.24937.

原田 仁

The learning effect of using stereoscopic vision in the early phase of laparoscopic surgical training for novices
Hitoshi Harada, Shingo Kanaji, Masayasu Nishi, Yoshito Otake, Hiroshi Hasegawa, Masashi Yamamoto, Yoshiko Matsuda, Kimihiro Yamashita, Takeru Matsuda, Taro Oshikiri, Yasuo Sumi, Tetsu Nakamura, Satoshi Suzuki, Yoshinobu Sato, Yoshihiro Kakeji
Surgical Endoscopy 2018 Feb;32(2):582-588.  doi: 10.1007/s00464-017-5654-2.

2016年度

高瀬 信尚

NCAM- and FGF-2-mediated FGFR1 signaling in the tumor microenvironment of esophageal cancer regulate the survival and migration of tumor-associated macrophages and cancer cells
Nobuhisa Takase, Yu-ichiro Koma, Naoki Urakawa, Mari Nishio, Noriaki Arai, Hiroaki Akiyama, Manabu Shigeoka, Yoshihiro Kakeji, Hiroshi Yokozaki
Cancer Letters 380 (2016) 47–58.  doi.org/10.1016/j.canlet.2016.06.009

音羽 泰則

Flt1/VEGFR1 heterozygosity causes transient embryonic edema
Yasunori Otowa, Kazumasa Moriwaki, Keigo Sano, Masanori Shirakabe, Shigenobu Yonemura, Masabumi Shibuya, Janet Rossant, Toshio Suda, Yoshihiro Kakeji, Masanori Hirashima
Scientific Reports. 2016 Jun 2;6:27186.  doi: 10.1038/srep27186.

西 将康

Quantitative comparison of operative skill using 2- and 3- dimensional monitors during laparoscopic phantom tasks
Masayasu Nishi, Shingo Kanaji, Yoshito Otake, Hitoshi Harada, Masashi Yamamoto, Taro Oshikiri, Tetsu Nakamura, Satoshi Suzuki, Yuki Suzuki, Yuta Hiasa, Yoshinobu Sato, Yoshihiro Kakeji
Surgery 2017 May;161(5):1334-1340  doi: 10.1016/j.surg.2016.08.060.

向山 順子

Evaluation of the risk of lymphomagenesis in xenografts by the PCR-based detection of EBV BamHI W region in patient cancer specimens.
Junko Mukohyama, Dai Iwakiri, Yoh Zen, Toru Mukohara, Hironobu Minami, Yoshihiro Kakeji, Yohei Shimono
Oncotarget. 2016 Aug 2;7(31):50150-50160.  doi: 10.18632/oncotarget.10322.

2015年度

大坪 大

Early-phase Treatment by Low-dose 5-Fluorouracil or Primary Tumor Resection Inhibits MDSC-mediated Lung Metastasis Formation
Dai Otsubo, Kimihiro Yamashita, Mitsugu Fujita, Masayasu Nishi, Yutaka Kimura, Hiroshi Hasegawa, Satoshi Suzuki, Yoshihiro Kakeji
Anticancer Res. 2015 Aug;35(8):4425-31.

瀧口 豪介

Wnt5a-Ror2 signaling in mesenchymal stem cells promotes proliferation of gastric cancer cells by activating CXCL16–CXCR6 axis
Gosuke Takiguchi, Michiru Nishita, Kana Kurita, Yoshihiro Kakeji, Yasuhiro Minami
Cancer Science 2016 Mar;107(3):290-7.  doi: 10.1111/cas.12871

2014年度

長谷川 寛

Allogeneic DCG Promote Lung NK Cell Activation and Antitumor Effect After Invariant NKT Cell Activation
Hiroshi Hasegawa, Kimihiro Yamashita, Dai Otubo, Shin-ichiro Fujii, Takashi Kamigaki, Daisuke Kuroda, Yoshihiro Kakeji
Anticancer Research. 2014 Jul;34(7):3411-7.

裏川 直樹

GDF15 derived from both tumor-associated macrophages and esophageal squamous cell carcinomas contributes to tumor progression via Akt and Erk pathways
Naoki Urakawa, Soken Utsunomiya, Mari Nishio, Manabu Shigeoka, Nobuhisa Takase, Noriaki Arai, Yoshihiro Kakeji, Yu-ichiro Koma, Hiroshi Yokozaki
Laboratory Investigation. 2015 May;95(5):491-503.  doi: 10.1038/labinvest.2015.36.

友野 絢子

Cell cycle kinetic analysis of colorectal neoplasms using a new automated immunohistochemistry-based cell cycle detection method
Ayako Tomono, Tomoo Itoh, Emmy Yanagita, Naoko Imagawa, Yoshihiro Kakeji
Medicine (Baltimore). 2015 Jan;94(4):e501.  doi: 10.1097/MD.0000000000000501.