神戸大学大学院医学研究科 内科系講座 先端緩和医療学分野 緩和支持治療科

研究

2023年度論文(英文) 2023年度論文(和文) 2022年度論文(英文) 2022年度論文(和文) 2021年度論文(英文) 2021年度論文(和文)

論文業績


2023年度 論文(英文）

 
  1. Yamaguchi T, Matsunuma R, Matsuda Y, Tasaki J, Ikari T, Miwa S, Aiki S, Takagi Y, Kiuchi D, Suzuki K, Oyamada S, Ariyoshi K, Kihara K, Mori M. Systemic opioids for dyspnea in cancer patients: A real-world observational study. J Pain Symptom Manage. 2023;65:400-8. (PMID: 36641006)　

  2. Lee ES, Hiratsuka Y, Suh SY, Won SH, Kim SH, Yoon SJ, Choi SE, Choi H, Ahn HY, Kim Y, Hui D, Cheng SY, Chen PJ, Wu CY, Mori M, Morita T, Yamaguchi T, Tsuneto S. Clinicians' Prediction of Survival and Prognostic Confidence in Patients with Advanced Cancer in Three East Asian Countries. J Palliat Med 2023; 26:790-7. (PMID: 36888535)

  3. Harano H, Matsunuma R, Tanaka-Yagi Y, Ito M, Tasaki J, Egawa A, Yamaguchi T. Malodour from oral malignant fungating wound: sprayed metronidazole - case report. BMJ Support Palliat Care. 2023 (PMID: 36944483)

  4. Mori M, Miwa S, Ikari T, Kako J, Hasegawa T, Matsunuma R, Suzuki K, Matsuda Y, Watanabe H, Morita T, Yamaguchi T. Current Management Options for Dyspnea in Cancer Patients. Curr Treat Options Oncol. 2023;24:565-79. (PMID: 37037975)

  5. Hamano J, Takeuchi A, Mori M, Saitou Y, Yamaguchi T, Miyata N, Shimizu M, Yamamoto R, Kimura Y, Kamiyama Y, Arai Y, Matsuo H, Shishido H, Nakano K, Nishi T, Nagaoka H, Yokomichi N, Maeda I, Yamaguchi T, Morita T, Shinjo T. Comparison of survival times of advanced cancer patients with palliative care at home and in hospital. PLoS One. 2023;18: e0284147. (PMID: 37053183)
  6. Mori M, Yamaguchi T, Suzuki K, Matsuda Y, Matsunuma R, Watanabe H, Ikari T, Matsumoto Y, Imai K, Yokomichi N, Miwa S, Yamauchi T, Okamoto S, Inoue S, Inoue A, Hui D, Morita T, Satomi E; Japanese Dyspnea Relief Investigators.　 Do types of opioids matter for terminal cancer dyspnea? A preliminary multicenter cohort study. J Pain Symptom Manage. 2023;66:e177-e184. (PMID: 37080479)

  7. Kadono T, Ishiki H, Yokomichi N, Ito T, Maeda I, Hatano Y, Miura T, Hamano J, Yamaguchi T, Ishikawa A, Suzuki Y, Arakawa S, Amano K, Satomi E, Mori M. Malignancy-related ascites in palliative care units: prognostic factor analysis. BMJ Support Palliat Care. 2023;13:e1292-e1299. (PMID: 37080735)

  8. Hasegawa T, Ochi T, Goya S, Matsuda Y, Kako J, Watanabe H, Kasahara Y, Kohara H, Mori M, Nakayama T, Yamaguchi T. Efficacy of supplemental oxygen for dyspnea relief in patients with advanced progressive illness: A systematic review and meta-analysis. Respir Investig. 2023;61:418-37. (PMID: 37105126)

  9. Yang CH, Chen PJ, Mori M, Morita T, Cheng SY, Suh SY, Kim SH, Yokomichi N, Imai K, Ito S, Yamaguchi T, Hiratsuka Y, Tsuneto S, Maeda S; EASED investigators. Cross-cultural comparison of continuous deep sedation for advanced cancer patients in East Asian countries: prospective cohort study. Jpn J Clin Oncol. 2023; 53:714-721. (PMID: 37114920)
  10. Yoon SJ, Suh SY, Hiratsuka Y, Choi SE, Kim SH, Koh SJ, Park SA, Seo JY, Kwon JH, Park J, Park Y, Hwang SW, Lee ES, Ahn HY, Cheng SY, Chen PJ, Yamaguchi T, Tsuneto S, Mori M, Morita T. Validation of Modified Models of Objective Prognostic Score in Patients With Advanced Cancer. J Palliat Med 2023;26:1064-73. (PMID: 37200448)
  11. Takagi Y, Sato J, Yamamoto Y, Matsunuma R, Watanabe H, Mori M, Hasegawa T, Matsuda Y, Kako J, Kasahara Y, Goya S, Kohara H, Nakayama T, Yamaguchi T. Opioids for the management of dyspnea in cancer patients: a systematic review and meta-analysis. Int J Clin Oncol 2023;28:999-1010. (PMID: 37338727)
  12. Shiraishi R, Kizawa Y, Mori M, Maeda I, Hatano Y, Ishiki H, Miura T, Yokomichi N, Kodama M, Inoue K, Otomo S, Yamaguchi T, Hamano J. Comparison of Symptom Severity and Progression in Advanced Cancer Patients Among Different Care Settings: A Secondary Analysis. Palliat Med Rep 2023; 4:139-49. (PMID: 37360680)
  13. Mori M, Lin CP, Cheng SY, Suh SY, Takenouchi S, Ng R, Chan H, Kim SH, Chen PJ, Yuen KK, Fujimori M, Yamaguchi T, Hamano J, Kizawa Y, Morita T, Martina D. Communication in Cancer Care in Asia: A Narrative Review. JCO Glob Oncol 2023;9:e2200266. (PMID: 37364221)
  14. van Esch HJ, Campbell ML, Mori M, Yamaguchi T. Should (Prophylactic) Medications Be Used for the Management of Death Rattle? J Pain Symptom Manage 2023 Oct;66;e513-e517.
  15. Huang HL, Chen PJ, Mori M, Suh SY, Wu CY, Peng JK, Shih CY, Yao CA, Tsai JS, Chiu TY, Hiratsuka Y, Kim SH, Morita T, Yamaguchi T, Tsuneto S, Hui D, Cheng SY. Improved Symptom Change Enhances Quality of Dying in Patients With Advanced Cancer: An East Asian Cross-Cultural Study. Oncologist 2023;29:e553-e560. (PMID: 37758042 )
  16. Takeda Y, Ishiki H, Oyamada S, Otani H, Maeda I, Yamaguchi T, Hamano J, Mori M, Morita T. Symptoms and Prognoses of Patients With Breast Cancer and Malignant Wounds in Palliative Care Units: The Multicenter, Prospective, Observational EASED Study. Am J Hosp Palliat Care. 2023 (PMID: 38056829)
  17. Hiratsuka Y, Suh SY, Yoon SJ, Choi SE, Kim SH, Hui D, Cheng SY, Huang HL, Chen PJ, Peng JK, Mori M, Yamaguchi T, Maeda I, Tsuneto S, Morita T. How different are accuracies of clinicians' prediction of survival by assessment methods? Ann Palliat Med. 2024;13:49-56. (PMID: 38124473)
  18. Ishii Y, Aoyama M, Abo H, Sakashita A, Matsumura Y, Miyashita M. Routine patient assessment and the use of patient-reported outcomes in specialized palliative care in Japan. J Patient Rep Outcomes. 2023 Mar 9;7(1):25. doi: 10.1186/s41687-023-00565-z.(PMID: 36894802)
  19. Satomi E, Kizawa Y, Miyazaki M, Tagami K, Sekine R, Suzuki K, Yotani N, Sugano K, Abo H, Sakashita A, Sato K, Nakagawa S, Nakazawa Y, Hamano J, Miyashita M. The effect of palliative care team intervention and symptom improvement using patient-reported outcomes: a multicenter prospective observational study. Support Care Cancer. 2023 Jul 3;31(7):439. doi: 10.1007/s00520-023-07912-2.(PMID: 37395791)
  20. Hayase T, Mieno MN, Mori N, et al. Inter-reporter differences in symptom burdens in Japanese children with cancer. Pediatr Int. Jan-Dec 2024;66(1):e15729. doi:10.1111/ped.15729

     

2023年度 論文(和文) 

 
  1. 山口 崇. がん疼痛治療 ～薬物療法の工夫～. 臨床薬理 2023;54:147-52.
  2. 伊藤 まどか、松沼 亮、原納 遥、田崎 潤一、山口 崇. フェンタニルよりモルヒネへオピオイドスイッチングを行いカルチノイド症候群に伴う難治性下痢が改善した1例. Palliat Care Res 2023;18:171-6.
  3. 奥田 有香、栗山 俊之、月山 淑、松田 能宜、山口 崇、森 雅紀、下川 敏雄、川股 知之. 呼吸困難のコントロールがオピオイドのみでは難しくミダゾラムを併用した終末期がん患者の要因. Palliat Care Res 2023;18:247-52.
  4. 合屋 将、中野 泰、十九浦 宏明、高木 雄亮、渡邊 紘章、松田 能宣、角甲 純、笠原 庸子、小原 弘之、森 雅紀、中山 健夫、山口 崇. 低酸素血症があり呼吸困難を有する進行性疾患患者に対する高流量鼻カニュラ酸素療法の有効性：システマティックレビュー. Paliat Care Res 2023;18:261-9.

  5. 田﨑　潤一・松沼　亮・山口　崇.　呼吸困難に対する高流量鼻カニュラ酸素療法

    緩和ケアVol. 33　No. 1　page015-019　青海社、2023

   
 

2022年度 論文(英文) 

 
  1. Yamaguchi T, Mori M, Maeda I, Matsunuma R, Tanaka-Yagi Y, Nishi T, Kizawa Y, Tsuneto S, Shima Y, Masukawa K, Miyashita M. The impact of death rattle on bereaved families: not the sound itself, but the resonance with their feelings. Jpn J Clin Oncol 2022;52:766-70；DOI: 10.1093/jjco/hyac055　PMID: 35446952
  2. Masuda K, Ishiki H, Yokomichi N, Yamaguchi T, Ito T, Takatsu H, Amano K, Hiramoto S, Yamauchi T, Kawaguchi T, Mori M, Matsuda Y, Yamaguchi T. Effect of paracentesis on the survival of patients with terminal cancer and ascites: a propensity score–weighted analysis of the East Asian Collaborative Cross‑cultural Study to Elucidate the Dying Process. Support Care Cancer 2022;30:6233-41；DOI: 10.1007/s00520-022-07057-8　PMID: 35449369
  3. Matsunuma R, Matsumoto K, Yamaguchi T, Sakashita A, Kizawa Y. Comprehensive palliative care needs in outpatients with chronic heart failure: A Japanese Cross-Sectional Study, Palliat Med Report 2022;3:65–74；DOI: 10.1089/pmr.2021.0063　PMID: 35558864
  4. Tanaka-Yagi Y, Yamaguchi T, Matsuda Y, Mori M, Ikari T, Miwa S, Suzuki K, Tachikawa R, Nakata K, Kanatani M. Morphine May Contribute to Improving Respiratory Failure in Severe COVID-19: A Case Report. Indian J Palliat Care. 2022;28:221-223；DOI: 10.25259/IJPC_132_2021　PMID: 35673688
  5. Hiratsuka Y, Suh SY, Won SH, Choi SE, Kim SH, Cheng SY, Chen PJ, Yoon SJ, Koh SJ, Park SA, Seo JY, Hui D, Yamaguchi T, Morita T, Tsuneto S, Mori M, Inoue A.  Is spiritual well-being related to survival time of inpatients with advanced cancer? An East Asian cohort study. Palliat Support Care. 2022 ；DOI: 10.1017/S1478951522000682　PMID: 35757916
  6. Hiratsuka Y, Kim D, Suh SY, Kim SH, Yoon SJ, Koh SJ, Park SA, Seo JY, Kwon JH, Park J, Park Y, Hwang SW, Lee ES, Choi H, Ahn HY, Cheng SY, Chen PJ, Yamaguchi T, Morita T, Tsuneto S, Mori M, Inoue A. Comparison of Objective Prognostic Score and Palliative Prognostic Score performance in inpatients with advanced cancer in Japan and Korea. Palliat Support Care. 2022;20:662-70；DOI: 10.1017/S1478951521001589　PMID: 36111731
  7. Ikari T, Hiratsuka Y, Cheng SY, Miyashita M, Morita T, Mori M, Uneno Y, Amano K, Uehara Y, Yamaguchi T, Maeda I, Inoue A. Factors associated with good death of patients with advanced cancer: a prospective study in Japan. Support Care Cancer 2022;30:9577-86；DOI: 10.1007/s00520-022-07363-1　PMID: 36125610
  8. Mori M, Yamaguchi T, Suzuki K, Matsuda Y, Matsunuma R, Watanabe H, Ikari T, Matsumoto Y, Imai K, Yokomichi N, Miwa S, Yamauchi T, Okamoto S, Inoue S, Inoue A, Morita T, Satomi E. The feasibility and effects of a pharmacological treatment algorithm for cancer patients with terminal dyspnea: A multicenter cohort study. Cancer Med. 2022 ；DOI: 10.1002/cam4.5362　PMID: 36259645 
  9. Yamaguchi T, Yokomichi N, Yamaguchi T, Maeda I, Matsunuma R, Tanaka-Yagi Y, Akatani A, Suzuki K, Kohara H, Taniyama T, Matsuda Y, Nakajima N, Morita T, Tsuneto S, Mori M. Anticholinergic drugs for death rattle in dying patients with cancer: multicentre prospective cohort study. BMJ Support Palliat Care. 2022；DOI: 10.1136/spcare-2022-003823　PMID: 36357162
  10. Simon ST, Mori M, Ekström M, Pralong A, Yamaguchi T, Hui D. Should benzodiazepines be used for reducing dyspnea in patients with advanced illnesses? J Pain Symptom Manage 2022 ；DOI: 10.1016/j.jpainsymman.2022.11.018　PMID: 36455801
  11. Taniguchi Y, Matsuda Y, Mori M, Ito M, Ikari T, Tokoro A, Aiki S, Hoshino S, Kiuchi D, Suzuki K, Igarashi Y, Odagiri T, Oya K, Kubo E, Yamaguchi T.　 Effectiveness and safety of opioids for dyspnea in patients with lung cancer: secondary analysis of multicenter prospective observational study. Transl Lung Cancer Res. 2022;11:2395-402； DOI: 10.21037/tlcr-22-512　PMID: 36636410
  12. Yasuda S, Sugano K, Matsuda Y, Kako J, Takagi Y, Watanabe H, Kasahara Y, Goya S, Kohara H, Mori M, Nakayama T, Yamaguchi T. Effectiveness and safety of opioids for dyspnea in patients with lung cancer: secondary analysis of multicenter prospective observational study. Jpn J Clin Oncol. 2023 in press ；DOI: 10.1093/jjco/hyac206　PMID: 36636762
  13. Yamaguchi T, Matsunuma R, Matsuda Y, Tasaki J, Ikari T, Miwa S, Aiki S, Takagi Y, Kiuchi D, Suzuki K, Oyamada S, Ariyoshi K, Kihara K, Mori M. Systemic opioids for dyspnea in cancer patients: A real-world observational study. J Pain Symptom Manage. 2023 in press. ；　DOI: 10.1016/j.jpainsymman.2022.12.146　PMID: 36641006
  14. Hayase T, Saiga H, Yamaguchi T. Haloperidol-induced myoclonus in a patient with delirium. Geriatr Gerontol Int. 2023 in press. ；　DOI: 10.1111/ggi.14550　PMID: 36709514
  15. Miyashita J, Shimizu S, *Shiraishi R*, Mori M, Okawa K, Aita K, MitsuokaS, Nishikawa M, Kizawa Y, Morita T, Fukuhara S, Ishibashi Y, Shimada C,Norisue Y, Ogino M, Higuchi N, Yamagishi A, Miura Y, Yamamoto Y. Culturally Adapted Consensus Definition and Action Guideline: Japan's Advance Care Planning. J Pain Symptom Manage 2022;64:602-613. ；DOI: 10.1016/j.jpainsymman.2022.09.005　PMID: 36115500
  16. Madoka Ito, Naoto Ishimaru, Toshio Shimokawa, Yoshiyuki Kizawa.　Risk factors for mortality in aspiration pneumonia: a single-center retrospective observational study. Monaldi Arch Chest Dis. 2022 Oct 13. DOI: 10.4081/monaldi.2022.2305. PMID: 36226555 
  17. Hiroki Isono, Haruka Kuno, Takunori Hozumi, Ken Emoto, Sho Nishiguchi, Masahiro Sakai, Madoka Ito, Koichi Kitamura, Kazuhito Hirose, Eiji Hiraoka, Naoto Ishimaru, Hiroyuki Kobayashi, Yasuharu Tokuda. Crowned dens syndrome: A case series of 72 patients at eight teaching hospitals in Japan. Journal of General and Family Medicine. 2023-03-20. DOI: 10.1002/jgf2.616
  18. Haruka Harano, Ryo Matsunuma, Yukako Tanaka-Yagi, Madoka Ito, Junichi Tasaki, Aki Egawa, Takashi Yamaguchi. Malodour from oral malignant fungating wound: sprayed metronidazole - case report. BMJ Support Palliat Care. 2023 Mar 21;spcare-2022-004137；DOI: 10.1136/spcare-2022-004137　PMID: 36944483
  19. Ito N, Ishii Y, Aoyama M, Abo H, Sakashita A, Matsumura Y, Miyashita M. Routine patient assessment and the use of patient-reported outcomes in specialized palliative care in Japan J Patient Rep Outcomes. 2023 Mar 9;7(1):25. DOI: 10.1186/s41687-023-00565-z.　PMID: 36894802

  20. Yokomichi N, Maeda I, Morita T, Yoshiuchi K, Ogawa A, Hisanaga T, Sakashita A, Nakahara R, Kaneishi K, Iwase S.

    Association of Antipsychotic Dose With Survival of Advanced Cancer Patients With Delirium. J Pain Symptom Manage. 2022 Jul;64:28-36. DOI: 10.1016/j.jpainsymman.2022.03.005  PMID: 35339614

  21. Shibata T, Oishi S, Mizuno A, Ohmori T, Okamura T, Kashiwagi H, Sakashita A, Kishi T, Obara H, Kakuma T, Fukumoto Y. Evaluation of the effectiveness of the physician education program on primary palliative care in heart failure.

     PLoS One. 2022 Feb 4;17；DOI: 10.1371/journal.pone.0263523　PMID: 35120191
     

2022年度 論文(和文)

　

  1. 平山 英幸、里見 絵理子、木澤 義之、宮崎 万友子、田上 恵太、関根 龍一、鈴木 梢、余谷 暢之、菅野 康二、安保 博文、坂下 明大、佐藤 一樹、中川 左理、中澤 葉宇子、浜野 淳、宮下 光令

    患者報告型アウトカムを用いた専門的緩和ケアの質評価のための患者登録システムの開発　多施設パイロット調査

    Palliative Care Research(1880-5302)17巻4号 Page171-180(2022.)

  2. 西 智弘、松本 禎久、森 雅紀、山口 崇 編. 緩和ケアレジデントマニュアル 第2版、 医学書院、2022

  3. 坂下 明大.【対話-傾聴を超えて】「対話」と緩和ケア(事例3)　医療現場で「傾聴」に限界を感じる時　共有型意思決定　

    緩和ケア(1349-7138)32巻6号 Page475-477(2022.11)

  4. 坂下 明大.　【CLTIの足病診療の実際】治す　共有型意思決定への患者の参加

    Heart View(1342-6591)26巻9号 Page914-919(2022.09)

  5. 五十嵐　佑子、木澤　義之. 　救急・集中治療における終末期医療　

    へるす出版　救急医学2022年12月　第46巻第12号

  6. 田﨑　潤一・松沼　亮・山口　崇.　呼吸困難に対する高流量鼻カニュラ酸素療法

    緩和ケアVol. 33　No. 1　page015-019　青海社、2023

     

   2021年度 論文(英文)

 
  1. Sharma A, Minh Duc NT, Luu Lam Thang T, Nam NH, Ng SJ, Abbas KS, Huy NT, Marušić A, Paul CL, Kwok J, Karbwang J, de Waure C, Drummond FJ, Kizawa Y , Taal E, Vermeulen J, Lee GHM, Gyedu A, To KG, Verra ML, Jacqz-Aigrain EM, Leclercq WKG, Salminen ST, Sherbourne CD, Mintzes B, Lozano S, Tran US, Matsui M, Karamouzian M. A Consensus-Based Checklist for Reporting of Survey Studies (CROSS). Gen Intern Med 2021；DOI: 10.1007/s11606-021-06737-1 J. PMID: 33886027
  2. Lin CP，Boufkhed S, Kizawa Y, Mori M, Hamzah E, Aggarwal G, Namisango E, Higginson IJ, Goh C, Harding R. Preparedness to face the COVID-19 pandemic in hospice and palliative care services in the Asia-Pacific region: A rapid online survey．Am J Hosp Palliat Care 2021;38: 861-868. DOI: 10.1177/10499091211002797. PMID: 33789503
  3. Yotani N, Shinjo D, Kato M, Matsumoto K, Fushimi K, Kizawa Y．Current status of intensive end-of-life care in children with hematologic malignancy: a population-based study. BMC Palliat Care 2021; 20: 82. DOI: 10.1186/s12904-021-00776-5. PMID: 34098925
  4. Igarashi N, Aoyama M, Masukawa K, Morita T, Kizawa Y, Tsuneto S, Shima Y, Miyashita M. Are cancer patients living alone more or less likely to achieve a good death? Two cross-sectional surveys of bereaved families. J Adv Nurs 2021;77, 3745-3758. DOI: 10.1111/jan.14886PMID: 34028846
  5. Hasegawa T, Akechi T, Osaga S, Tsuji T, Okuyama T, Sakurai H, Masukawa K, Morita T, Kizawa Y, Tsuneto S, Shima Y, Miyashita M．Unmet need for palliative rehabilitation in inpatient hospices/palliative care units: a nationwide post-bereavement survey．Jpn J Clin Oncol 2021;51: 1334-1338. DOI: 10.1093/jjco/hyab093.PMID: 34117492
  6. Kizawa Y, Yamaguchi T, Yagi Y, Miyashita M, Shima Y, Ogawa A. Conditions, possibility and priority for admission into inpatient hospice/palliative care units in Japan: a nationwide survey. Jpn J Clin Oncol 2021, 51, 1437–1443, DOI: 10.1093/jjco/hyab098. PMID: 34184056
  7. Matsunuma R, Yamaguchi T, Mori M, Ikari T, Suzuki K, Matsuda Y, Matsumoto Y, Watanabe H, Amano K, Kamura R, Kizawa Y. Predictive Factors for the Development of Dyspnea Within 7 Days After Admission Among Terminally Ill Cancer Patients. Am J Hosp Palliat Care 2022; 39: 413-420. DOI: 10.1177/10499091211028817. PMID: 34235973
  8. Shimizu Y, Hayashi A, Maeda I, Miura T, Inoue A, Takano M, Aoyama M, Matsuoka Y J, Morita T, Kizawa Y, Tsuneto S, Shima Y, Masukawa K, Miyashita M. Changes in depressive symptoms among family caregivers of patients with cancer after bereavement and their association with resilience: A prospective cohort study. Psychooncology 2022; 31: 86-97. DOI: 10.1002/pon.5783 PMID: 34343380 
  9. Tagami K, Masukawa K, Inoue A, Morita T, Hiratsuka Y, Sato M, Kohata K, Satake N, Kizawa Y, Tsuneto S, Shima Y, Miyashita M. Appropriate Referral Timing to Specialized Palliative Care Service: Survey of Bereaved Families of Cancer Patients who Died in Palliative Care Units. Support Care Cancer 2022; 30: 931-940. DOI: 10.1007/s00520-021-06493-2. PMID: 34417885
  10. Akechi T, Ito Y, Ogawa A, Kizawa Y．Essential competences for psychologists in palliative cancer care teams. Jpn J Clin Oncol 2021, 51, 1587–1594, DOI: 10.1093/jjco/hyab133. PMID: 34378045
  11. Hamano J, Masukawa K, Tsuneto S, Shima Y, Morita T, Kizawa Y, Miyashita M. Are family relationships associated with family conflict in advanced cancer patients? Psychooncology 2022;31:260-270. DOI: 10.1002/pon.5801. PMID: 34453463
  12. Kizawa Y, Yamaguchi T, Sakashita A, Aoyama M, Morita T，Tsuneto S, Shima Y，Miyashita M．Physician's Communication in code status discussions for terminally ill cancer patients in inpatient hospice/palliative care units in Japan: A nationwide post-bereavement survey． J Pain Symptom Manage 2021 ;62:e120-e129. DOI: 10.1016/j.jpainsymman.2021.03.011. PMID: 33757891
  13. Tokoro A, Imai H, Fumita S, Harada T, Noriyuki T, Gamoh M, Okamoto M, Akashi Y, Kizawa Y. Opioid-Induced Constipation in Patients with Cancer Pain in Japan (OIC-J Study): A Post Hoc Analysis. J Clin Med 2021;10:4193. DOI: 10.3390/jcm10184193. PMID: 34575301
  14. Okada H, Morita T, Kiuchi T, Okuhara T, Kizawa Y. Health care providers’ knowledge, confidence, difficulties, and practices after completing a communication skills training program for advance care planning discussion in Japan.  Ann Palliat Med 2021; 10:7225-7235. DOI: 10.21037/apm-21-642PMID: 34263640
  15. Bayly J, Bone A, Ellis-Smith C, Tunnard I, Yaqub S, Yi  D, Nkhoma K B, Cook A, Combes S, Bajwah S, Harding R, Nicholson C, Normand C, Ahuja S, Turrillas P, Kizawa Y, Morita T, Nishiyama N, Tsuneto S, Ong P, Higginson I, Evans C, Maddocks M. Common elements of service delivery models that optimise quality of life and health service use among older people with advanced progressive conditions: a tertiary systematic review.  BMJ Open 2021 ;11:e048417. DOI: 10.1136/bmjopen-2020-048417. PMID: 34853100
  16. Okada H, Kiuchi T, Okuhara T, Kizawa Y.  Effect of advance care planning discussions with trained nurses in older adults with chronic diseases in Japan. Ann Palliat Med 2022;11:412-422. DOI: 10.21037/apm-21-2161. PMID: 34775775 
  17. Shimizu Y, Hayashi A, Maeda I, Miura T, Inoue A, Takano M, Aoyama M, Matsuoka J Y, Morita T, Kizawa Y, Tsuneto S, Shima Y, Masukawa K. Changes in depressive symptoms among family caregivers of patients with cancer after bereavement and their association with resilience: A prospective cohort study.  Psycho-Oncology 2021;31:86-97 DOI:10.1002/pon5783 2021 PMID: 34343380
  18. Imai K, Morita T, Mori M, Yokomichi N, Yamauchi T, Miwa S, Inoue S, Shirado Naito A, Masukawa K, Kizawa Y, Tsuneto S, Shima Y, Otani H, Miyashita M. Family experience of palliative sedation therapy: proportional vs continuous deep sedation. Support Care Cancer 2022; 30:3903-3912.DOI: 10.1007/s00520-021-06745-1. PMID: 35039967
  19. Mori M, Kawaguchi T, Imai K, Yokomichi N, Yamaguchi T, Suzuki K, Matsunuma R, Watanabe H, Maeda I, Uehara Y, Morita T; EASED Investigators. How successful is parenteral oxycodone for relieving terminal cancer dyspnea compared with morphine? A multicenter prospective observational study. J Pain Symptom Manage 2021 ;62:336-345. DOI: 10.1016/j.jpainsymman.2020.11.037. PMID: 33290857
  20. Mori M, Kawaguchi T, Imai K, Yokomichi N, Yamaguchi T, Suzuki K, Matsunuma R, Watanabe H, Maeda I, Matsumoto Y, Matsuda Y, Morita T; EASED Investigators. Visualizing how to use parenteral opioids for terminal cancer dyspnea: A pilot, multicenter, prospective, observational study.  J Pain Symptom Manage 2021 ;62:936-948. DOI: 10.1016/j.jpainsymman.2021.05.001. PMID: 33992759
  21. Suzuki K, Ikari T, Matsunuma R, Matsuda Y, Matsumoto Y, Miwa S, Mori M, Yamaguchi T, Watanabe H, Tanaka K. The possibility of conducting a clinical trial on palliative care: A survey of whether a clinical study on cancer dyspnea is acceptable to cancer patients and their relatives.  J Pain Symptom Manage 2021;62:1262-1272. DOI: 10.1016/j.jpainsymman.2021.05.012. PMID: 34058319
  22. Imai K, Morita T, Yokomichi N, Kawaguchi T, Kohara H, Yamaguchi T, Kikuchi A, Odagiri T, Watanabe YS, Kamura R, Maeda I, Kawashima N, Ito S, Baba M, Matsuda Y, Oya K, Kaneishi K, Hiratsuka Y, Naito AS, Mori M. Efficacy of proportional sedation and deep sedation defined by sedation protocols: A multicenter, prospective, observational comparative study: Protocol-based palliative sedation.  J Pain Symptom Manage 2021;62:1165-1174. DOI: 10.1016/j.jpainsymman.2021.06.005. PMID: 34118372
  23. Hiratsuka Y, Suh SY, Kim SH, Cheng SY, Yoon SJ, Koh SJ, Park SA, Seo JY, Kwon JH, Park J, Park Y, Hwang SW, Lee ES, Ahn HY, Hui D, Chen PJ, Yamaguchi T, Morita T, Tsuneto S, Mori M, Inoue A; and the EASED Investigators. Factors related to spiritual well-being in the last days of life in three East Asian countries: An international multicenter prospective cohort study. Palliat Med. 2021;35:1564-1577. DOI: 10.1177/02692163211022179. PMID: 34148395
  24. Chung JH, Kim SH, Suh SY, Cheng SY, Mori M, Yamaguchi T, Chen PJ, Morita T, Tsuneto S; EASED Investigators. Differences between dedicated and not dedicated hospice physicians in symptoms and signs improvement among advanced cancer patients.  Medicine (Baltimore). 2021;100:e26915. DOI: 10.1097/MD.0000000000026915. PMID: 34397931
  25. Mori M, Yamaguchi T, Maeda I, Hatano Y, Yamaguchi T, Imai K, Kikuchi A, Matsuda Y, Suzuki K, Tsuneto S, Hui D, Morita T; EASED collaborators. Diagnostic models for impending death in terminally ill cancer patients: A multicenter cohort study. Cancer Med. 2021;10:7988-7995. DOI: 10.1002/cam4.4314. PMID: 34586714
  26. Yokomichi N, Morita T, Yamaguchi T. Hydration Volume Is Associated with Development of Death Rattle in Patients with Abdominal Cancer. J Palliat Med. 2022;25:130-134. DOI: 10.1089/jpm.2021.0297. PMID: 34665043 
  27. Suh SY, Won SH, Hiratsuka Y, Choi SE, Cheng SY, Mori M, Chen PJ, Yamaguchi T, Morita T, Tsuneto S, LeBlanc TW, Kim SH, Yoon SJ, Lee ES, Hwang SW. Assessment of Changes in Symptoms Is Feasible and Prognostic in the Last Weeks of Life: An International Multicenter Cohort Study. J Palliat Med. 2022;25:388-395. DOI: 10.1089/jpm.2021.0212. PMID: 34668798 
  28. Hiratsuka Y, Yoon SJ, Suh SY, Choi SE, Hui D, Kim SH, Lee ES, Hwang SW, Cheng SY, Chen PJ, Mori M, Yamaguchi T, Morita T, Tsuneto S, Inoue A. Comparison of the accuracy of clinicians' prediction of survival and Palliative Prognostic Score: an East Asian cross-cultural study. Support Care Cancer. 2022;30:2367-2374. DOI: 10.1007/s00520-021-06673-0. PMID: 34743238
  29. Matsuda Y, Yamaguchi T, Matsumoto Y, Ishiki H, Usui Y, Kako J, Suzuki K, Matsunuma R, Mori M, Watanabe H, Zenda S. Research policy in supportive care and palliative care for cancer dyspnea. Jpn J Clin Oncol 2022;52:260–265. DOI:10.1093/jjco/hyab193. PMID: 34894136
  30. Yokomichi N, Yamaguchi T, Maeda I, Mori M, Imai K, Shirado Naito A, Yamaguchi T, Terabayashi T, Hiratsuka Y, Hisanaga T, Morita T. Effect of continuous deep sedation on survival in the last days of life of cancer patients: A multicenter prospective cohort study. Palliat Med. 2022;36:189-199. DOI: 10.1177/02692163211057754. PMID: 35067124
  31. Ishiki H, Hamano J, Nagaoka H, Matsuda Y, Tokoro A, Matsuoka H, Izumi H, Sakashita A, Kizawa Y, Oyamada S, Yamaguchi T, Iwase S. Prevalence of Extrapyramidal Symptoms in Cancer Patients Referred to Palliative Care: A Multicenter Observational Study (JORTC PAL12). Am J Hosp Palliat Care. 2021;38:823-829. DOI: 10.1177/1049909120960441. PMID: 32940536
  32. Hatano Y, Morita T, Mori M, Maeda I, Oyamada S, Naito AS, Oya K, Sakashita A, Ito S, Hiratsuka Y, Tsuneto S. EASED Investigators. Complexity of desire for hastened death in terminally ill cancer patients: A cluster analysis. Palliat Support Care. 2021; 1:1-10. DOI: 10.1017/S1478951521000080. PMID: 33641697
  33. Anzai T, Sato T, Fukumoto Y, Izumi C, Kizawa Y, Koga M, Nishimura K, Ohishi M, Sakashita A, Sakata Y, Shiga T, Takeishi Y, Yasuda S, Yamamoto K, Abe T, Akaho R, Hamatani Y, Hosoda H, Ishimori N, Kato M, Kinugasa Y, Kubozono T, Nagai T, Oishi S, Okada K, Shibata T, Suzuki A, Suzuki T, Takagi M, Takada Y, Tsuruga K, Yoshihisa A, Yumino D, Fukuda K, Kihara Y, Saito Y, Sawa Y, Tsutsui H, Kimura T; Japanese Circulation Society Joint Working Group. JCS/JHFS 2021 Statement on Palliative Care in Cardiovascular Diseases. Circ J. 2021;85:695-757. DOI: 10.1253/circj.CJ-20-1127. PMID: 33775980
  34. Shibata T, Oishi S, Mizuno A, Ohmori T, Okamura T, Kashiwagi H, Sakashita A, Kishi T, Obara H, Kakuma T, Fukumoto Y. Evaluation of the effectiveness of the physician education program on primary palliative care in heart failure. PLoS One 2022;17:e0263523. DOI: 10.1371/journal.pone.0263523. PMID: 35120191
  35. Nishijima K, Kizawa Y, Yamauchi T, Odagiri T, Ito T, Kaneishi K, Shimizu K, Morita T, Mori M. Prevalence and associated factors of orphan symptoms in advanced cancer patients: a multicenter observational study. Support Care Cancer 2021; 29: 5537-5547.  DOI: 10.1007/s00520-021-06144-6. PMID: 33725175
  36. Maeda I, Satomi E, Kiuchi D, Nishijima K, Matsuda Y, Tokoro A, Tagami K, Matsumoto Y, Naito A, Morita T, Iwase S; Phase-R N/V Study Group, Otani H, Odagiri T, Watanabe H, Mori M, Matsuda Y, Nagaoka H, Mayuzumi M, Kanai Y, Sakamoto N, Ariyoshi K. Patient-perceived symptomatic benefits of olanzapine treatment for nausea and vomiting in patients with advanced cancer who received palliative care through consultation teams: a multicenter prospective observational study. Support Care Cancer 2021 ;29:5831-5838. DOI: 10.1007/s00520-021-06067-2. PMID: 33742244
  37. Tanaka Y, Kato A, Ito K, Igarashi Y, Kinoshita S, Kizawa Y, Miyashita M. Attitudes of Physicians toward Palliative Care in Intensive Care Units: A Nationwide Cross-Sectional Survey in Japan. J Pain Symptom Manage 2022; 63: 440-448. DOI: 10.1016/j.jpainsymman.2021.09.015. PMID: 34656654
   

2021年度 論文(和文)

　
  1. 木澤義之． アドバンス・ケア・プランニングの実践とその効用 日本内科学会雑誌 第110巻 第9号 Page1926-1931 Sep.2021
  2. 石黒 洋、石橋 英樹、山口 崇、綿貫 成明、華井 明子、桜井 なおみ、辻 哲也. 「プレフレイル高齢大腸がん患者のための臨床的提言」支持・緩和医療に関する提言　
    日本大腸肛門病会誌 2021;74:349-56.
  3. 鷹津 英, 八木 佑加子, 大前 隆仁, 山口 崇. 少量ヒドロモルフォン投与中に神経毒性を呈した腎機能障害を有する2例. Palliat Care Research 2021;16:267-70.
  4. 角甲 純 , 中村 陽一, 西 智弘, 高木 雄亮, 松田 能宣, 渡邊 紘章, 笠原 庸子, 合屋 将, 小原 弘之, 森 雅紀, 山口 崇. 呼吸困難を有する慢性進行性疾患患者に対する送風療法の有効性：システマティックレビュー・メタ解析 Palliative Care Research 2022;17:33-42.

  

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