研究成果

  • すべて
  • 2025年
  • 2024年

2025年

【原著論文】｜2025年度

  1. Junko Asakura, Manabu Nagao, Masakazu Shinohara, Tetsuya Hosooka, Naoya Kuwahara, Makoto Nishimori, Hidekazu Tanaka, Seimi Satomi-Kobayashi, Sho Matsui, Tsutomu Sasaki, Tadahiro Kitamura, Hiromasa Otake, Tatsuro Ishida, Wataru Ogawa, Ken-Ichi Hirata, Ryuji Toh. Impaired cardiac branched-chain amino acid metabolism in a novel model of diabetic cardiomyopathy. Cardiovasc Diabetol. 2025;24(1):167.
  2. Naoya Kuwahara, Manabu Nagao, Masakazu Shinohara, Kenta Kaneshiro, Takuo Emoto, Takeshi Yoshida, Terunobu Fukuda, Makoto Nishimori, Seimi Satomi-Kobayashi, Hiromasa Otake, Ken-Ichi Hirata, Tatsuro Ishida, RyujiToh. ACLY Promotes Cardiac Fibrosis via the Regulation of DNL and Histone Acetylation. Hypertension. 2025;82(6):1116-1128.

2024年

【原著論文】｜2024年度

  1. Tomoyo Hamana, Makoto Nishimori, Satoki Shibata, Hiroyuki Kawamori, Takayoshi Toba, Takashi Hiromasa, Shunsuke Kakizaki, Satoru Sasaki, Hiroyuki Fujii, Yuto Osumi, Seigo Iwane, Tetsuya Yamamoto, Shota Naniwa, Yuki Sakamoto, Yuta Fukuishi, Koshi Matsuhama, Hiroshi Tsunamoto, Hiroya Okamoto, Kotaro Higuchi, Tatsuya Kitagawa, Masakazu Shinohara, Koji Kuroda, Masamichi Iwasaki, Amane Kozuki, Junya Shite, Tomofumi Takaya, Ken-Ichi Hirata, Hiromasa Otake. Deep-learning-driven optical coherence tomography analysis for cardiovascular outcome prediction in patients with acute coronary syndrome. Eur Heart J Digit Health. 2024;5(6):692-701.
  2. Tatsuhiro Ayabe, Masakazu Shinohara, Masahiro Kita, Chika Takahashi, Jiro Saito, Tomoyuki Furuyashiki, Kenji Toba, Satoshi Umeda, Yasuhisa Ano. Supplementation with whey peptide rich in β-lactolin improves trait anxiety and subjective stress in healthy adults: a randomized, double-blind, placebo-controlled study. Sci Rep. 2024;14(1):23444.
  3. Yuya Suzuki, Takuo Emoto, Shunsuke Sato, Takeshi Yoshida, Mitsuhiko Shoda, Hiromi Endoh, Manabu Nagao, Tomoyo Hamana, Taishi Inoue, Tomohiro Hayashi, Eriko Nitta, Hiroki Konishi, Kunihiko Kiuchi, Mitsuru Takami, Kimitake Imamura, Masayuki Taniguchi, Masatoshi Inoue, Toshihiro Nakamura, Yusuke Sonoda, Hiroyuki Takahara, Kazutaka Nakasone, Kyoko Yamamoto, Kenichi Tani, Hidehiro Iwai, Yusuke Nakanishi, Shogo Yonehara, Atsushi Murakami, Ryuji Toh, Takenao Ohkawa, Tomoyuki Furuyashiki, Ryo Nitta, Tomoya Yamashita, Ken-Ichi Hirata, Koji Fukuzawa. Left atrial single-cell transcriptomics reveals amphiregulin as a surrogate marker for atrial fibrillation. Commun Biol. 2024;7(1):1601.
  4. Susumu Odajima, Wataru Fujimoto, Misa Takegami, Kunihiro Nishimura, Masamichi Iwasaki, Masanori Okuda, Akihide Konishi, Masakazu Shinohara, Manabu Nagao, Ryuji Toh, Ken-Ichi Hirata, Hidekazu Tanaka. BEEAF2 Score: A New Risk Stratification Score for Patients With Stage B Heart Failure From the KUNIUMI Registry Chronic Cohort. J Am Heart Assoc. 2024;13(19):e034793. Kazutaka Nakasone , Makoto Nishimori , Masakazu Shinohara , Mitsuru Takami , Kimitake Imamura , Taku Nishida , Akira Shimane , Yasushi Oginosawa , Yuki Nakamura , Yasuteru Yamauchi , Ryudo Fujiwara , Hiroyuki Asada , Akihiro Yoshida , Kaoru Takami , Tomomi Akita , Takayuki Nagai , Philipp Sommer , Mustapha El Hamriti , Hiroshi Imada , Luigi Pannone , Andrea Sarkozy , Gian Battista Chierchia , Carlo de Asmundis , Kunihiko Kiuchi , Ken-ichi Hirata , Koji Fukuzawa. Enhancing origin prediction: deep learning model for diagnosing premature ventricular contractions with dual-rhythm analysis focused on cardiac rotation. Europace. 2024;26(10):euae240.
  5. Takuya Iino, Manabu Nagao, Hidekazu Tanaka, Sachiko Yoshikawa, Junko Asakura, Makoto Nishimori, Masakazu Shinohara, Amane Harada, Shunsuke Watanabe, Tatsuro Ishida, Ken-Ichi Hirata, Ryuji Toh. Assessment of transthyretin instability in patients with wild-type transthyretin amyloid cardiomyopathy. Sci Rep. 2024;14(1):20508.
  6. Emma Tabe Eko Niba, Hiroyuki Awano, Noriyuki Nishimura, Hiroshi Koide, Masafumi Matsuo, Masakazu Shinohara. Differential metabolic secretion between muscular dystrophy mouse-derived spindle cell sarcomas and rhabdomyosarcomas drives tumor type development. Am J Physiol Cell Physiol. 2024;327(1):C34-C47.
  7. Hidekazu Tanaka, Tatsuro Ishida, Takuo Emoto, Manabu Nagao, Yu Izawa, Terunobu Fukuda, Takayoshi Toba, Eriko Hisamatsu, Yu Taniguchi, Kimitake Imamura, Mitsuru Takami, Hiroyuki Kawamori, Hiromasa Otake, Koji Fukuzawa, Ryuji Toh, Seimi Satomi-Kobayashi, Tomoya Yamashita, Ken-Ichi Hirata. Overview of the 88th Annual Scientific Meeting of the Japanese Circulation Society (JCS2024) - The Future of Cardiology - Challenges in Overcoming Cardiovascular Disease. Circ J. 2024;88(9):1502-1508.
  8. Chizuko Maruyama, Miya Uchiyama, Ariko Umezawa, Aoi Tokunaga, Akari Yasuda, Kanako Chibai, Chieko Fukuda Rina Ichiki, Noriko Kameyama, Masakazu Shinohara. A Cross-Sectional Pilot Study on Association of Ready-to-Eat and Processed Food Intakes with Metabolic Factors, Serum Trans Fat and Phospholipid Fatty Acid Compositions in Healthy Japanese Adults. Nutrients. 2024;16(7):1032.
  9. Yutaro Seto, Manabu Nagao, Takuya Iino, Amane Harada, Katsuhiro Murakami, Keiko Miwa, Masakazu Shinohara, Makoto Nishimori, Sachiko Yoshikawa, Junko Asakura, Tomoo Fujioka, Tatsuro Ishida, Ken-Ichi Hirata, Ryuji Toh. Impaired Cholesterol Uptake Capacity in Patients with Hypertriglyceridemia and Diabetes Mellitus. J Appl Lab Med. 2024:jfae024.
  10. lo Horikawa, Hirotaka Nagai, Masayuki Taniguchi, Guowei Chen, Masakazu Shinohara, Tomohide Suzuki, Shinichi Ishii, Yoshio Katayama, Shiho Kitaoka, Tomoyuki Furuyashiki. Chronic stress alters lipid mediator profiles associated with immune-related gene expressions and cell compositions in mouse bone marrow and spleen. J Pharmacol Sci. 2024;154(4):279-293.
  11. Shuji Ueda, Yuka Yoshida, Biniam Kebede, Chiaki Kitamura, Ryo Sasaki, Masakazu Shinohara, Itsuko Fukuda, Yasuhito Shirai. New Implications of Metabolites and Free Fatty Acids in Quality Control of Crossbred Wagyu Beef during Wet Aging Cold Storage. Metabolites. 2024;14(2):95.
  12. Makoto Nishimori, Naomi Hayasaka, Kazunori Otsui, Nobutaka Inoue, Junko Asakura, Manabu Nagao, Ryuji Toh, Tatsuro Ishida, Ken-Ichi Hirata, Tomoyuki Furuyashiki, Masakazu Shinohara. Stress-induced stenotic vascular remodeling via reduction of plasma omega-3 fatty acid metabolite 4-oxoDHA by noradrenaline. Sci Rep. 2024;14(1):4178.
  13. Wataru Fujimoto, Susumu Odajima, Hiroshi Okamoto, Masamichi Iwasaki, Manabu Nagao, Akihide Konishi, Masakazu Shinohara, Ryuji Toh, Masanori Okuda, Ken-Ichi Hirata, Hidekazu Tanaka. Importance of B-Type Natriuretic Peptide in the Detection of Patients With Structural Heart Disease in a Primary Care Setting. Circ J. 2024;88(5):732-739.
  14. Mina Arai-Okuda Yusuke Murai Hidetaka Maeda Akiyasu Kanamori Takako Miki Tomoko Naito Kazunobu Sugihara Michihiro Kono Masaki Tanito Hiromitsu Onoe Kazuyuki Hirooka Yoshiaki Kiuchi Masakazu Shinohara Sentaro Kusuhara Sotaro Mori Kaori Ueda Mari Sakamoto Yuko Yamada-Nakanishi Makoto Nakamura. Potentially compromised systemic and local lactate metabolic balance in glaucoma, which could increase retinal glucose and glutamate concentrations. Sci Rep 2024;14(1):3683.
  15. Kenta Kaneshiro, Kanako Nakagawa, Hikari Tsukamoto, Genta Matsuoka, Seitaro Okuno, Koji Tateishi, Yasuhiro Terashima, Nao Shibanuma, Kohsuke Yoshida, Akira Hashiramoto. The clock gene Bmal1 controls inflammatory mediators in rheumatoid arthritis fibroblast-like synoviocytes. Biochem Biophys Res Commun. 2024:691:149315.
  16. Toru Tanaka Naoto Sasaki Aga Krisnanda Masakazu Shinohara Hilman Zulkifli Amin Sayo Horibe Ken Ito Motoaki Iwaya Atsushi Fukunaga Ken Ichi Hirata Yoshiyuki Rikitake. Novel UV-B Phototherapy With a Light-Emitting Diode Device Prevents Atherosclerosis by Augmenting Regulatory T-Cell Responses in Mice. J Am Heart Assoc. 2024;13(2):e031639.

【著書】

  1. 杜 隆嗣、平田 健一. 第1部 検査項目の選択と臨床検査の総合評価 循環器疾患. 臨床検査ガイド2025年改訂版. 2024年.

【学会発表】

  1. ATP citrate lyase promotes cardiac fibrosis via the regulation of de novo lipogenesis and histone acetylation. 桑原 直也, 長尾 学, 篠原 正和. 第8回日本循環器学会基礎フォーラム（BCVR）. 2024年12月.
  2. 転写因子TCF21による血管平滑筋形質変換の制御. 長尾 学. 第56回日本動脈硬化学会学術集会. シンポジウム. 2024年7月.
  3. 心血管疾患二次予防におけるHDLコレステロール取り込み能の有用性. 杜 隆嗣. 第56回日本動脈硬化学会学術集会. シンポジウム. 2024年7月.
  4. Effectiveness of ezetimibe and colestimide against hypercholesterolemia associated with heterozygous mutations of ABCG5 or 8. 藤岡　知夫, 長尾 学, 杜 隆嗣. 第56回日本動脈硬化学会学術集会. 2024年7月.
  5. Implications of Altered Amino Acid Metabolism in the Failing Heart. 長尾 学, 第88回日本循環器学会学術集会. 神戸. シンポジウム. 2024年3月.
  6. Meet the Expert 5. Challenge to establish a novel HDL-directed prevention strategy in atherosclerosis. 杜 隆嗣, 第88回日本循環器学会学術集会. 神戸. シンポジウム. 2024年3月.
  7. Hypercholesterolemia with heterozygous pathogenic mutations in ABCG5 genes.藤岡 知夫, 長尾 学, 杜 隆嗣, 平田 健一. 第88回日本循環器学会学術集会. 神戸. 2024年3月.
  8. Plasma cystine/methionine ratio is associated with left ventricular diastolic function in patients with Heart failure. 朝倉 絢子, 長尾 学, 杜 隆嗣, 平田 健一. 第88回日本循環器学会学術集会. 神戸. 2024年3月.
  9. Assessment of Transthyretin Instability in Patients with Wild-type Transthyretin Amyloid Cardiomyopathy. 飯野琢也, 長尾 学, 杜 隆嗣, 平田 健一. 第88回日本循環器学会学術集会. 神戸. 2024年3月.

【受賞】

  1. 第8回日本循環器学会基礎フォーラム(BCVR) Poster Award. ATP citrate lyase promotes cardiac fibrosis via the regulation of de novo lipogenesis and histone acetylation. 桑原直也、長尾学、篠原正和. 2024年12月