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Welcome to Nakamura lab!

 

Our lab focus on the molecular mechanism of sphingosine 1-phosphate signaling.

 

 


Lab news

5/2018 New paper in Journal of Biological Chemistry.

Extracellular α-synuclein drives sphingosine 1-phosphate receptor subtype 1 out of lipid rafts, leading to impaired inhibitory G protein signaling. Badawy, SMM., Okada, T., Kajimoto, T., Hirase, M., Matovelo, SA., Nakamura, S., Yoshida, D., Ijuin, T., Nakamura, SI. J. Biol. Chem. 293, 8208-8216 (2018)

1/2018 New paper in Journal of Biological Chemistry.

Involvement of Gβγ subunits of Gi protein coupled with S1P receptor on multivesicular endosomes in F-actin formation and cargo sorting into exosomes. Kajimoto, T., Mohamed, NNI., Badawy, SMM., Matovelo, SA., Hirase, M., Nakamura, S., Yoshida, D., Okada, T., Ijuin, T., Nakamura, SI. J. Biol. Chem. 293, 245-253 (2018)

11/2017 New paper in Scientific Reports.

DHHC5-mediated palmitoylation of S1P receptor subtype 1 determines G-protein coupling. Badawy, SMM., Okada, T., Kajimoto, T., Ijuin, T., Nakamura, SI. Sci. Rep. 7:16552 . doi:10.1038/s41598-017-16457-4 (2017)