原著論文

Kobayashi K, Maeda K, Takefuji M, Kikuchi R, Morishita Y, Hirashima M, Murohara T. Dynamics of angiogenesis in ischemic areas of the infarcted heart. Sci Rep 7(1):7156, 2017

Jang JY, Choi SY, Park I, Park DY, Choe K, Kim P, Kim YK, LeeBJ, Hirashima M, Kubota Y, Park JW, Cheng SY, Nagy A, Park YJ, Alitalo K, Shong M, Koh GY. VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis. EMBO Mol Med 9(6):750-769, 2017

Danno S, Kubouchi K, Mehruba M, Abe M, Natsume R, Sakimura K, Eguchi S, Oka M, Hirashima M, Yasuda H, Mukai H. PKN2 is essential for mouse embryonic development and proliferation of mouse fibroblasts. Genes Cells 22(2):220-236, 2017

Ogura S, Kurata K, Hattori Y, Takase H, Ishiguro-Oonuma T, Hwang Y, Ahn S, Park I, Ikeda W, Kusuhara S, Fukushima Y, Nara H, Sakai H, Fujiwara T, Matsushita J, Ema M, Hirashima M, Minami T, Shibuya M, Takakura N, Kim P, Miyata T, Ogura Y, Uemura A. Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown. JCI Insight 2(3):e90905, 2017

Liu X, Uemura A, Fukushima Y, Yoshida Y, Hirashima M. Semaphorin 3G provides a repulsive guidance cue to lymphatic endothelial cells via Neuropilin-2/PlexinD1. Cell Rep 17(9):2299-2311, 2016

Otowa Y, Moriwaki K, Sano K, Shirakabe M, Yonemura S, Shibuya M, Rossant J, Suda T, Kakeji Y, Hirashima M. Flt1/VEGFR1 heterozygosity causes transient embryonic edema. Sci Rep 6:27186, 2016

Majima T, Takeuchi K, Sano K, Hirashima M, Okamoto MT, Ishizaki H, Miyoshi J, Ogita H. An adaptor molecule Afadin regulates lymphangiogenesis by modulating RhoA activity in the developing mouse embryo. PLoS One 8(6):e68134, 2013

Katsuta H, Fukushima Y, Maruyama K, Hirashima M, Nishida K, Nishikawa SI, Uemura A. EphrinB2-EphB4 signals regulate formation and maintenance of funnel-shaped valves in corneal lymphatic capillaries. Invest Ophthalmol Vis Sci 54(6):4102-4108, 2013

Ikushima YM, Arai F, Nakamura Y, Hosokawa K, Kubota Y, Hirashima M, Toyama H, Suda T. Enhanced Angpt1/Tie2 signaling affects the differentiation and long-term repopulation ability of hematopoietic stem cells. Biochem Biophys Res Commun 430(1):20-25, 2013

Kusuhara S, Fukushima Y, Fukuhara S, Jakt LM, Okada M, Shimizu Y, Hata M, Nishida K, Negi A, Hirashima M, Mochizuki N, Nishikawa S, Uemura A. Arhgef15 Promotes Retinal Angiogenesis by Mediating VEGF-Induced Cdc42 Activation and Potentiating RhoJ Inactivation in Endothelial Cells. PLoS One 7(9):e45858, 2012

Osada M, Inoue O, Ding G, Shirai T, Ichise H, Hirayama K, Takano K, Yatomi Y, Hirashima M, Fujii H, Suzuki-Inoue K, Ozaki Y. Platelet activation receptor CLEC-2 regulates blood/lymphatic vessel separation by inhibiting proliferation, migration, and tube formation of lymphatic endothelial cells. J Biol Chem 287(26):22241-22252, 2012

Sano K, Katsuta O, Shirae S, Kubota Y, Ema M, Suda T, Nakamura M, Hirashima M. Flt1 and Flk1 mediate regulation of intraocular pressure and their double heterozygosity causes the buphthalmia in mice. Biochem Biophys Res Commun 420(2):422-427, 2012

Fukuhara S, Simmons S, Kawamura S, Inoue A, Orba Y, Tokudome T, Sunden Y, Arai Y, Moriwaki K, Ishida J, Uemura A, Kiyonari H, Abe T, Fukamizu A, Hirashima M, Sawa H, Aoki J, Ishii M, Mochizuki N. The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice. J Clin Invest 122(4):1416-1426, 2012

Kubota Y, Takubo K, Hirashima M, Nagoshi N, Kishi K, Okuno Y, Nakamura-Ishizu A, Sano K, Murakami M, Ema M, Omatsu Y, Takahashi S, Nagasawa T, Shibuya M, Okano H, Suda T. Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero. J Exp Med 208(5):949-960, 2011

Fukushima Y, Okada M, Kataoka H, Hirashima M, Yoshida Y, Mann F, Gomi F, Nishida K, Nishikawa S, Uemura A. Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice. J Clin Invest 121(5):1974-1985, 2011

Sanematsu F, Hirashima M, Laurin M, Takii R, Nishikimi A, Kitajima K, Ding G, Noda M, Murata Y, Tanaka Y, Masuko S, Suda T, Meno C, Cote JF, Nagasawa T, Fukui Y. DOCK180 Is a Rac Activator That Regulates Cardiovascular Development by Acting Downstream of CXCR4. Circ Res 107(9):1102-1105, 2010

Sison K, Eremina V, Baelde H, Min W, Hirashima M, Fantus IG, Quaggin SE. Glomerular structure and function require paracrine, not autocrine, VEGF-VEGFR-2 signaling. J Am Soc Nephrol 21(10):1691-1701, 2010

Suzuki-Inoue K, Inoue O, Ding G, Nishimura S, Hokamura K, Eto K, Kashiwagi H, Tomiyama Y, Yatomi Y, Umemura K, Shin Y, Hirashima M, Ozaki Y. Essential in vivo roles of the c-type lectin receptor CLEC-2: Embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets. J Biol Chem 285(32):24494-24507, 2010

Harada K, Yamazaki T, Iwata C, Yoshimatsu Y, Sase H, Mishima K, Morishita Y, Hirashima M, Oike Y, Suda T, Miura N, Watabe T, Miyazono K. Identification of targets of Prox1 during in vitro vascular differentiation from embryonic stem cells: functional roles of HoxD8 in lymphangiogenesis. J Cell Sci 122(Pt 21):3923-3930, 2009

Albuquerque RJ, Hayashi T, Cho WG, Kleinman ME, Dridi S, Takeda A, Baffi JZ, Yamada K, Kaneko H, Green MG, Chappell J, Wilting J, Weich HA, Yamagami S, Amano S, Mizuki N, Alexander JS, Peterson ML, Brekken RA, Hirashima M, Capoor S, Usui T, Ambati BK, Ambati J. Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth. Nat Med 15(9):1023-1030, 2009

Kanemura H, Satoh T, Bilasy SE, Ueda S, Hirashima M, Kataoka T. Impaired vascular development in the yolk sac and allantois in mice lacking RA-GEF-1. Biochem Biophys Res Commun 387(4):754-759, 2009

Benedito R, Trindade A, Hirashima M, Henrique D, Lopes-da-Costa L, Rossant J, Gill PS, Duarte A. Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli. BMC Dev Biol 8:117, 2008

Kubota Y, Hirashima M, Kishi K, Stewart CL, Suda T. Leukemia inhibitory factor regulates microvessel density by modulating oxygen-dependent VEGF expression. J Clin Invest 118(7):2393-2403, 2008

Kawasaki K, Watabe T, Sase H, Hirashima M, Koide H, Morishita Y, Yuki K, Sasaoka T, Suda T, Katsuki M, Miyazono K, Miyazawa K. Ras signaling directs endothelial specification of VEGFR2+ vascular progenitor cells. J Cell Biol 181(1):131-141, 2008

Hirashima M, Sano K, Morisada T, Murakami K, Rossant J, Suda T. Lymphatic vessel assembly is impaired in Aspp1-deficient mouse embryos. Dev Biol 316(1):149-159, 2008

Murakami M, Zheng Y, Hirashima M, Suda T, Morita Y, Ooehara J, Ema H, Fong GH and Shibuya M. VEGFR1 tyrosine kinase signaling promotes lymphangiogenesis as well as angiogenesis indirectly via macrophage recruitment. Arterioscler Thromb Vasc Biol 28(4):658-664, 2008

Mishima K, Watabe T, Saito A, Yoshimatsu Y, Imaizumi N, Masui S, Hirashima M, Morisada T, Oike Y, Araie M, Niwa H, Kubo H, Suda T, Miyazono K. Prox1 induces lymphatic endothelial differentiation via integrin a9 and other signaling cascades. Mol Biol Cell 18(4):1421-1429, 2007

Duarte A*, Hirashima M*, Benedito R, Trindade A, Diniz P, Bekman E, Costa L, Henrique D, Rossant J (*equally contributed). Dosage-sensitive requirement for mouse Dll4 in artery development. Genes Dev 18(20):2474-2478, 2004

Hirashima M, Bernstein A, Stanford WL, Rossant J. Gene trap expression screening to identify endothelial-specific genes. Blood 104(3):711-718, 2004

Kimura Y, Jones N, Kluppel M, Hirashima M, Tachibana K, Cohn JB, Wrana JL, Pawson T, Bernstein A. Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages. Proc Natl Acad Sci U S A 101(16): 6015-6020, 2004

Hirashima M, Lu Y, Byers L, Rossant J. Trophoblast expression of fms-like tyrosine kinase 1 is not required for the establishment of the maternal-fetal interface in the mouse placenta. Proc Natl Acad Sci U S A 100(26):15637-15642, 2003

Hirashima M, Ogawa M, Nishikawa S, Matsumura K, Kawasaki K, Shibuya M, Nishikawa SI. A chemically defined culture of VEGFR2+ cells derived from embryonic stem cells revealed the role of VEGFR1 in tuning the threshold for VEGF in developing endothelial cells. Blood 101(6):2261-2267, 2003

Matsumura K, Hirashima M, Ogawa M, Kubo H, Hisatsune H, Kondo N, Nishikawa S, Chiba T, Nishikawa SI. Modulation of VEGFR-2-mediated endothelial-cell activity by VEGF-C/VEGFR-3. Blood 101(4):1367-1374, 2003

Ema M, Faloon P, Zhang WJ, Hirashima M, Reid T, Stanford WL, Orkin S, Choi K and Rossant J. Combinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development in the mouse. Genes Dev 17(3):380-393, 2003

Uemura A, Ogawa M, Hirashima M, Fujiwara T, Koyama S, Takagi H, Honda Y, Wiegand SJ, Yancopoulos GD, Nishikawa SI. Recombinant angiopoietin-1 restores higher order architecture on growing blood vessels in absence of mural cells. J Clin Invest 110(11):1619-1628, 2002

Kimura Y, Hart A, Hirashima M, Wang C, Holmyard D, Pittman J, Pang XL, Jackson CW, Bernstein A. Zinc finger protein, Hzf, is required for megakaryocyte development and hemostasis. J Exp Med 195(7):941-952, 2002

Yamashita J, Itoh H, Hirashima M, Ogawa M, Nishikawa S, Yurugi T, Naito M, Nakao K, Nishikawa SI. Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors. Nature 408(6808):92-96, 2000

Hirashima M, Kataoka H, Nishikawa S, Matsuyoshi N, Nishikawa SI. Maturation of embryonic stem cells into endothelial cells in an in vitro model of vasculogenesis. Blood 93(4):1253-1263, 1999

Nishikawa SI, Nishikawa S, Hirashima M, Matsuyoshi N, Kodama H. Progressive lineage analysis by cell sorting and culture identifies FLK1+VE-cadherin+ cells at a diverging point of endothelial and hemopoietic lineages. Development 125(9):1747-1757, 1998

Aye TT, Uchida T, Becker SO, Hirashima M, Shikata T, Komine F, Moriyama M, Arakawa Y, Mima S, Mizokami M, Lau JYN. Variation of hepatitis B virus precore/core gene sequence in acute and fulminant hepatitis B. Dig Dis Sci 39(6):1281-1287, 1994

Uchida T, Aye TT, Becker SO, Hirashima M, Shikata T, Komine F, Moriyama M, Arakawa Y, Takase S, Mima S. Detection of precore/core-mutant hepatitis B virus (HBV) genome in patients with acute or fulminant hepatitis without serological markers for recent HBV infection. J Hepatol 18(3):369-372, 1993



分担執筆

平島正則.遺伝子変異マウスの胎児浮腫とリンパ管形成異常.リンパ浮腫の外科的治療(光嶋勲・編);ぱーそん書房:103-111,2017

平島正則.動脈・静脈・リンパ管の発生.血管新生研究の最先端(佐藤靖史,高倉伸幸・編);医薬ジャーナル社:34-41,2013

平島正則.リンパ管分化.血管生物医学事典(日本血管生物医学会・編);朝倉書店:168-169,2011

平島正則.vasculogenesisとangiogenesis.血管生物医学事典(日本血管生物医学会・編);朝倉書店:162-163,2011

平島正則.動脈と静脈の内皮細胞分化の分子機構.急速進展する血管研究(宮園浩平,佐藤靖史・編);羊土社:40-45,2006

Nishikawa SI, Nishikawa S, Fraser ST, Fujimoto T, Yoshida H, Hirashima M, Ogawa M. Developmental relationship of hematopoietic stem cells and endothelial cells. In Hematopoiesis, A developmental approach ed. Zon LI.; Oxford University Press, NY:pp171-179, 2001

平島正則.血管発生の分子機構とin vitroでの再現.動脈硬化の最前線(北徹・編);羊土社:23-33,1999

平島正則.血管を構成する細胞の発生.血管新生の最前線−そのメカニズムと病態・治療(佐藤靖史・編);羊土社:22-31,1999



総説

平島正則.リンパ管パターニングに関わる分子シグナル.炎症と免疫 24(5):379-384, 2016

平島正則.リンパ管形成におけるAspp1の役割.生体の科学 63(6):555-560, 2012

平島正則.リンパ管研究の最近の動向.生体の科学 63(6):542-548, 2012

佐野圭吾,平島正則.VEGF(vascular endothelial growth factor)受容体.日本臨床 70(増刊号8):31-35, 2012

Hirashima M. Regulation of endothelial cell differentiation and arterial specification by VEGF and Notch signaling. Anat Sci Int 84(3):95-101, 2009

森脇一将,平島正則.アンジオポエチンとリンパ管新生.分子細胞治療 7(5):401-407, 2008

Hirashima M, Suda T. Differentiation of arterial and venous endothelial cells and vascular morphogenesis. Endothelium 13(2):137-145, 2006

平島正則.血管パターン形成におけるNotchシグナルの役割.Molecular Medicine 42(7):777-782, 2005

Rossant J, Hirashima M. Vascular development and patterning: making the right choices. Curr Opin Genet Dev 13(4):408-412, 2003

Nishikawa SI, Hirashima M, Nishikawa S, Ogawa M. Cell biology of vascular endothelial cells. Ann N Y Acad Sci 947:35-40; discussion 41, 2001

平島正則,西川伸一.血管内皮細胞の発生学〜発生過程の内皮細胞を用いた新しいモデル系による解析.実験医学 17(6):716-720, 1999

平島正則,小川峰太郎.血管/血液の発生分化とES (Embryonic Stem)細胞.診断と治療 86(12):1995-2000, 1998

Yoshida H, Takakura N, Hirashima M, Kataoka H, Tsuchida K, Nishikawa S, Nishikawa SI. Hematopoietic tissues, as a playground of receptor tyrosine kinases of the PDGF-receptor family. Dev Comp Immunol 22(3):321-332, 1998