細胞分子医学
神戸大学大学院 医学系研究科
Division of Molecular and Metabolic Medicine
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主な英語論文

2015 / 2014 / 2013 / 2012 / 2011 / 2010 / 2009 / 2008 / 2007 / 2006 / 2005 / 2004 / 2003 / 2002 / 2001
2000 / 1999 / 1998 / 1997 / 1996 / 1995

2015

Tamura K, Minami K, Kudo M, Iemoto K, Takahashi H, Seino S:
Liraglutide improves pancreatic Beta cell mass and function in alloxan-induced diabetic mice.
PLoS One 10:e0126003, 2015

Takahashi H, Shibasaki T, Park JH, Hidaka S, Takahashi T, Ono A, Song DK, Seino S:
Role of Epac2A/Rap1 signaling in interplay between incretin and sulfonylurea in insulin secretion.
Diabetes 64:1262-1272, 2015

Nukaya D, Minami K, Hoshikawa R, Yokoi N, Seino S:
Preferential gene expression and epigenetic memory of induced pluripotent stem cells derived from mouse pancreas.
Genes Cells 20:367-381, 2015

Yokoi N, Beppu M, Yoshida E, Hoshikawa R, Hidaka S, Matsubara T, Shinohara M, Irino Y, Hatano N, Seino S:
Identification of putative biomarkers for prediabetes by metabolome analysis of rat models of type 2 diabetes.
Metabolomics (in press) (published online, Mar. 12, 2015)

Gheni G, Yokoi N, Beppu M, Yamaguchi T, Hidaka S, Kawabata A, Hoshino Y, Hoshino M, Seino S:
Characterization of the prediabetic state in a novel rat model of type 2 diabetes, the ZFDM rat.
J. Diabetes Res. 2015:261418, 2015

2014

Gheni G, Ogura M, Iwasaki M, Yokoi N, Minami K, Nakayama Y, Harada K, Hastoy B, Wu X, Takahashi H, Kimura K, Matsubara T, Hoshikawa R, Hatano N, Sugawara K, Shibasaki T, Inagaki N, Bamba T, Mizoguchi A, Fukusaki E, Rorsman P, Seino S:
Glutamate acts as a key signal linking glucose metabolism to incretin/cAMP action to amplify insulin secretion.
Cell Rep. 9:661-673, 2014

Shibasaki T, Takahashi T, Takahashi H, Seino S:
Cooperation between cAMP signaling and sulfonylurea in insulin secretion.
Diabetes Obes. Metab. 16 (Suppl. 1):118-125, 2014

Yabe D, Seino Y:
Dipeptidyl peptidase-4 inhibitors and sulfonylureas for type 2 diabetes: Friend or Foe?
J. Diabetes Investig. 5:475–477, 2014

2013

Takahashi T, Shibasaki T, Takahashi H, Sugawara K, Ono A, Inoue N, Furuya T, Seino S:
Antidiabetic Sulfonylureas and cAMP Cooperatively Activate Epac2A.
Sci. Signal. 6(298):ra94, 2013
Summary:Abstract: Reprint:Full Text:

Uenishi E, Shibasaki T, Takahashi H, Seki C, Hamaguchi H, Yasuda T, Tatebe M, Oiso Y, Takenawa T, Seino S:
Actin dynamics regulated by the balance of neuronal Wiskott-Aldrich syndrome protein (N-WASP) and cofilin activities determines the biphasic response of glucose-induced insulin secretion.
J. Biol. Chem. 288:25851-25864, 2013

Minami K, Seino S:
Current status of regeneration of pancreatic b-cells.
J. Diabetes Invest. 4:131-141, 2013

Yokoi N, Hoshino M, Hidaka S, Yoshida E, Beppu M, Hoshikawa R, Sudo K, Kawada A, Takagi S, Seino S:
A novel rat model of type 2 diabetes: the Zucker Fatty Diabetes Mellitus ZFDM rat.
J. Diabetes Res. Article ID 103731, 9 pages, 2013

2012

Matsubara T, Mita A, Minami K, Hosooka T, Kitazawa S, Takahashi K, Tamori Y, Yokoi N, Watanabe M, Matsuo E, Nishimura O, Seino S:
PGRN is a key adipokine mediating high-fat diet-induced insulin resistance and obesity through IL-6 in adipose tissue.
Cell Metab. 15:38-50, 2012

Seino S:
Cell signalling in insulin secretion: the molecular targets of ATP, cAMP and sulfonylurea.
Diabetologia 55:2096-108, 2012

Yokoi N, Hidaka S, Tanabe S, Ohya M, Ishima M, Takagi Y, Masui N, Seino S:
Role of major histocompatibility complex class II in the development of autoimmune type 1 diabetes and thyroiditis in rats.
Genes Immun. 13:139-145, 2012

このページの先頭へ

2011

Seino S, Shibasaki T, Minami K:
Dynamics of insulin secretion and the clinical implications for obesity and diabetes.
J Clin. Invest. 121:2118-2125, 2011

Minami K, Doi R, Kawaguchi Y, Nukaya D, Hagiwara Y, Noguchi H, Matsumoto S, Seino S:
In vitro generation of insulin-secreting cells from human pancreatic exocrine cells.
J. Diabetes Invest. 2: 271–275, 2011

Nakamura K, Minami K, Tamura K, Iemoto K, Miki T, Seino S:
Pancreatic β-cells are generated by neogenesis from non-β-cells after birth.
Biomed. Res. 32:167-174, 2011

このページの先頭へ

2010

Yasuda T, Shibasaki T, Minami K, Takahashi H, Mizoguchi A, Uriu Y, Numata T, Mori Y, Miyazaki J-I, Miki T, Seino S:
Rim2a determines docking and priming states in insulin granule exocytosis.
Cell Metab. 12:117-129, 2010

Seino S, Zhang C-L, Shibasaki T:
Sulfonylurea action re-revisited.
J. Diabetes Invest. 1: 37–39, 2010

Minami K, Miyawaki K, Hara M, Yamada S, Seino S:
Tracing phenotypic reversibility of pancreatic β-cells in vitro.
J. Diabetes Invest. 1:242-251, 2010

Iwasaki M, Minami K, Shibasaki T, Miki T, Miyazaki J-I, Seino S:
Establishment of new clonal pancreatic β-cell lines (MIN6-K) useful for study of incretin/cAMP signaling.
J. Diabetes Invest. 1:137-142, 2010

Seino S, Shibasaki T, Minami K:
Pancreatic beta-cell signaling: toward better understanding of diabetes and its treatment.
Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. 86:563-577, 2010

このページの先頭へ

2009

Zhang CL, Katoh M, Shibasaki T, Minami K, Sunaga Y, Takahashi H, Yokoi N, Iwasaki M, Miki T, Seino S:
The cAMP sensor Epac2 is a direct target of antidiabetic sulfonylurea drugs.
Science 325:607-610, 2009

Fujimoto W, Miki T, Ogura T, Zhang M, Seino Y, Satin LS, Nakaya H, Seino S:
Niflumic acid-sensitive ion channels play an important role in the induction of glucose-stimulated insulin secretion by cyclic AMP in mice.
Diabetologia 52:863-872, 2009

Niimura M, Miki T, Shibasaki T, Fujimoto W, Iwanaga T, Seino S:
Critical role of the N-terminal cyclic AMP-binding domain of Epac2 in its subcellular localization and function.
J. Cell Physiol. 219:652-658, 2009

Sugawara K, Shibasaki T, Mizoguchi A, Saito T, Seino S:
Rab11 and its effector Rip11 participate in regulation of insulin granule exocytosis.
Genes Cells 14:445-456. , 2009

このページの先頭へ

2008

Fuse M, Yokoi N, Shinohara M, Masuyama T, Kitazawa R, Kitazawa S, Seino S:
Identification of a major locus for islet inflammation and fibrosis in the spontaneously diabetic Torii rat.
Physiol. Genomics 35:96-105, 2008

Minami K, Okano H, Okumachi A, Seino S:
Role of cadherin-mediated cell-cell adhesion in pancreatic exocrine-to-endocrine transdifferentiation.
J. Biol. Chem. 283:13753-13761, 2008

Yokoi N, Fujiwara Y, Wang HY, Kitao M, Hayashi C, Someya T, Kanamori M, Oiso Y, Tajima N, Yamada Y, Seino Y, Ikegami H, Seino S:
Identification and functional analysis of CBLB mutations in type 1 diabetes.
Biochem. Biophys. Res. Commun. 368:37-42, 2008

Seino Y, Miki T, Kiyonari H, Abe T, Fujimoto W, Kimura K, Takeuchi A, Takahashi Y, Oiso Y, Iwanaga T, and Seino S:
Isx participates in the maintenance of vitamin A metabolism by regulation of beta-carotene 15,15'-monooxygenase (Bcmo1) expression.
J. Biol. Chem. 283:4905-4911, 2008

このページの先頭へ

2007

Shibasaki T, Takahashi H, Miki T, Sunaga Y, Matsumura K, Yamanaka M, Zhang C, Tamamoto A, Satoh T, Miyazaki J, and Seino S:
Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP.
Proc Natl Acad Sci USA 104:19333-19338, 2007

Fujimoto W, Shiuchi T, Miki T, Minokoshi Y, Takahashi Y, Takeuchi A, Kimura K, Saito M, Iwanaga T, and Seino S:
Dmbx1 is essential in agouti-related protein action.
Proc Natl Acad Sci USA 104:15514-15519, 2007

Yokoi N, Hayashi C, Fujiwara Y, Wang HY, and Seino S:
Genetic reconstitution of autoimmune type 1 diabetes with two major susceptibility genes in the rat.
Diabetes 56:506-512, 2007

Okuno M, Minami K, Okumachi A, Miyawaki K, Yokoi N, Toyokuni S, and Seino S:
Generation of insulin-secreting cells from pancreatic acinar cells of animal models of type 1 diabetes.
Am. J. Physiol. Endocrinol. Metab. 292:E158-165, 2007

このページの先頭へ

2006

Yokoi N, Kanamori M, Horikawa Y, Takeda J, Sanke T, Furuta H, Nanjo K, Mori H, Kasuga M, Hara K, Kadowaki T, Tanizawa Y, Oka Y, Iwami Y, Ohgawara H, Yamada Y, Seino Y, Yano H, Cox NJ, and Seino S:
Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects.
Diabetes 55:2379-2386, 2006

Oyama K, Minami K, Ishizaki K, Fuse M, Miki T, and Seino S:
Spontaneous recovery from hyperglycemia by regeneration of pancreatic beta-cells in Kir6.2G132S transgenic mice.
Diabetes 55:1930-1938, 2006

Kawaguchi M, Minami K, Nagashima K, and Seino S:
Essential role of ubiquitin-proteasome system in normal regulation of insulin secretion.
J. Biol. Chem. 281:13015-13020, 2006

Zhang C, Miki T, Shibasaki T, Yokokura M, Saraya A, and Seino S:
Identification and characterization of a novel member of the ATP-sensitive K+ channel subunit family, Kir6.3, in zebrafish.
Physiol. Genomics 24:290-297, 2006

このページの先頭へ

2005

Minami K, Okuno M, Miyawaki K, Okumachi A, Ishizaki K, Oyama K, Kawaguchi M, Ishizuka N, Iwanaga T. and Seino S:
Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatinc acinar cells.
Proc Natl Acad Sci U.S.A. 102:15116-15121, 2005

Miki T, Minami K, Shinozaki H, Matsumura K, Saraya A, Ikeda H, Yamada Y, Holst J.J, Seino S:
Distinct effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 on potentiation of insulin secretion.
Diabetes 54:1056-1063, 2005

Sasaki T, Shibasaki T, Beguin P, Nagashima K, Miyazaki M, Seino S:
Direct inhibition of the interaction between AID and BID of voltage-dependent Ca2+ channels by Gem.
J. Biol. Chem. 280:9308-9312, 2005

Zhang C, Miki T, Shibasaki T, Yokokura M, Saraya A. and Seino S:
Identification and characterization of a novel member of the ATP-sensitive K+ channel subunit family, Kir6.3, in zebrafish.
Physiol. Genomics. 24:290-297, 2005

Kimura K, Miki T, Shibasaki T, Zhang Y, Ogawa M, Saisho H, Okuno M, Seino S:
Functional analysis of the transcriptional repressor Otx3/Dmbx1.
FEBS Lett. 579:2926-2932, 2005

Matsumura K, Miki T, Jhomori T, Gonoi T, Seino S:
Possible role of PEPT1 in gastrointestinal hormone secretion.
Biochem. Biophys. Res. Commun. 336:1028-1032, 2005

Liss B, Haeckel O, Wildmann J, Miki T, Seino S. and Roeper J:
K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons.
Nat. Neurosci. 8:1742-1751, 2005

このページの先頭へ

2004

Matsumoto M, Miki T, Shibasaki T, Kawaguchi M, Shinozaki H, Nio J, Saraya A, Koseki H, Miyazaki M, Iwanaga T, Seino S:
Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells.
Proc. Natl. Acad. Sci. U.S.A. 101:8313-8318, 2004

Shibasaki T, Sunaga Y, Fujimoto K, Kashima Y, Seino S:
Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent calcium channel in insulin granule exocytosis.
J. Biol. Chem. 279:7956-7961, 2004

Kosoy R, Yokoi N, Seino S, Concannon P:
Polymorphic variation in the CBLB gene in human type 1 diabetes.
Genes Immun. 5:232-235, 2004

Saraya A, Yokokura M, Gonoi T, Seino S:
Effects of fluoroquinolones on insulin secretion and β-cell ATP-sensitive K+ channels.
Eur. J. Pharmacol. 497:111-117, 2004

Shibasaki T, Sunaga Y, Seino S:
Integration of ATP, cAMP, and Ca2+ signals in insulin granule exocytosis.
Diabetes 53 Suppl 3: 59-62, 2004

Nishimura M, Yokoi N, Miki T, Horikawa Y, Yoshioka H, Takeda J, Ohara O, Seino S:
Construction of multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.
DNA Res. 11: 315-323, 2004

このページの先頭へ

2003

Minami K, Morita M, Saraya A, Yano H, Terauchi Y, Miki T, Kuriyama T, Kadowaki T, Seino S:
ATP-sensitive K+ channel-mediated glucose uptake is independent of IRS-1/phosphatidylinositol 3-kinase signaling
Am. J. Physiol. Endocrinol. Metab. 285:E1289-96, 2003

Yokoi N, Namae M, Fuse M, Wang HY, Hirata T, Seino S, Komeda K:
Establishment and characterization of the Komeda diabetes-prone rat as a segregating inbred strain
Exp. Anim. 52:295-301, 2003

Yokoi N, Namae M, Wang HY, Kojima K, Fuse M, Yasuda K, Serikawa T, Seino S, Komeda K:
Rat neurological disease creeping is caused by a mutation in the reelin gene.
Brain Res. Mol. Brain Res. 112:1-7, 2003

Seino S, Miki T:
Physiological and pathophysiological roles of ATP-sensitive K+ channels.
Prog. Biophys. Mol. Biol. 81:133-76, 2003

このページの先頭へ

2002

Miki T, Suzuki M, Shibasaki T, Uemura H, Sato T, Yamaguchi K, Koseki H, Iwanaga T, Nakaya H, Seino S:
Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1
Nature Med. 8:466-472, 2002

Zhang Y, Miki T, Iwanaga T, Koseki Y, Okuno M, Sunaga Y, Ozaki N, Yano H, Koseki H, Seino S:
Identification, tissue expression, and functional characterization of Otx3, a novel member of the Otx family.
J. Biol. Chem. 277: 28065-28069, 2002

Minami K, Yokokura M, Ishizuka N, Seino S:
Normalization of intracellular Ca2+ induces a glucose-responsive state in glucose-unresponsive beta-cells.
J. Biol. Chem. 277: 25277-25282, 2002

Fujimoto K, Shibasaki T, Yokoi N, Kashima Y, Matsumoto M, Sasaki T, Tajima N, Iwanaga T, Seino S:
Piccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2.Piccolo complex in cAMP-dependent exocytosis.
J. Biol. Chem. 277:50497-502.2002

Miki T, Minami K, Zhang L, Morita M, Gonoi T, Shiuchi T, Minokoshi Y, Renaud JM, Seino S:
ATP-sensitive potassium channels participate in glucose uptake in skeletal muscle and adipose tissue.
Am. J. Physiol. Endocrinol. Metab. 283:E1178-84, 2002

Yokoi N, Komeda K, Wang H-Y, Yano H, Kitada K, Saitoh Y, Seino Y, Yasuda K, Serikawa T, Seino S: Cbl-b is a major susceptibility gene for rat type1 diabetes mellitus.
Nature Genet. 31:391-394, 2002

このページの先頭へ

2001

Beguin P, Nagashima K, Gonoi T, Shibasaki T, Takahashi K, Kashima Y, Ozaki N, Geering K,Iwanaga T, Seino S:
Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem.
Nature 411:701-706, 2001

Yamada K, Ji JJ, Yuan H, Miki T, Sato S, Horimoto N, Shimizu T, Seino S, Inagaki N:
Protective role of ATP-sensitive potassium channels in hypoxia-induced generalized seizure.
Science 292:1543-1546, 2001

Miki T, Liss B, Minami1 K, Shiuchi T, Saraya1 A, Kashima Y, Horiuchi M, Ashcroft F, Minokoshi Y, Roeper J, Seino S:
ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis.
Nature Neurosci. 5:507-512, 2001

S. Seino:
S20G mutation of the amylin gene is associated with Type II diabetes in Japanese.
Diabetologia 44:906-909, 2001

このページの先頭へ

2000

Ozaki N, Shibasaki T, Kashima Y, Miki T, Takahashi K, Ueno H, Sunaga Y, Yano H, Matsuura Y, Iwanaga T, Takai Y, Seino S:
cAMP-GEFII is a direct target of cAMP in regulated exocytosis.
Nature Cell Biol. 2:805-811, 2000

Wang CZ, Yano H, Nagashima K, Seino S:
T he Na+-driven Cl-/HCO3- exchanger. Cloning, tissue distribution, and functional characterization.
J. Biol. Chem. 275: 35486-35490, 2000.

Mitsuhashi N, Miki T, Senbongi H, Yokoi N, Yano H, Miyazaki M, Nakajima N, Iwanaga T, Yokoyama Y, Shibata T, Seino S:
MTABC3, a novel mitochondrial ATP-binding cassette protein involved in iron homeostasis.
J. Biol. Chem. 275:17536-17540, 2000

Minami K, Yano H, Miki T, Nagashima K, Wang CZ, Tanaka H, Miyazaki JI, Seino S:
Insulin secretion and differential gene expression in glucose-responsive and -unresponsive MIN6 sublines.
Am. J. Physiol. Endocrinol. Metab. 279:E773-781, 2000

Seino S, Iwanaga T, Nagashima K, Miki T:
Diverse roles of KATP channels learned from Kir6.2 genetically engineered mice.
Diabetes 49:311-318, 2000

このページの先頭へ

1999

Liu M, Seino S, Kirchgessner AL:
Identification and characterization of glucoresponsive neurons in the enteric nervous system.
J. Neurosci. 19:10305-10317, 1999

Beguin P, Nagashima K, Nishimura M, Gonoi T, Seino S:
PKA-mediated phosphorylation of the human KATP channel: separate roles of Kir6.2 and SUR1 subunit phosphorylation.
EMBO J. 18: 4722-4732, 1999

Kawaki J, Nagashima K, Tanaka J, Miki T, Miyazaki M, Gonoi T, Mitsuhashi N, Nakajima N, Iwanaga T, Yano H, Seino S:
Unresponsiveness to glibenclamide during chronic treatment induced by reduction of ATP-sensitive K+ channel activity.
Diabetes 48:2001-2006, 1999

Nishimura M, Miki T, Yashima R, Yokoi N, Yano H, Sato Y, Seino S:
Angiopoietin-3, a novel member of the angiopoietin family.
FEBS Lett. 448:254-256, 1999

Sunaga, Y., Inagaki, N., Gonoi, T., Yamada, Y., Ishida, H., Seino, Y. and Seino,S:
Troglitazone but not pioglitazone affects ATP-sensitive K+ channel activity.
Eur. J. Pharmacol. 381:71-76, 1999

Seino S:
ATP-sensitive potassium channels: a model of heteromultimeric potassium channel/receptor assemblies.
Annu. Rev. Physiol. 61:337-362, 1999

Miki T, Nagashima K, Seino S:
The structure and function of the ATP-sensitive K+ channel in insulin-secreting pancreatic beta-cells.
J. Mol. Endocrinol. 22: 113-123, 1999


このページの先頭へ

1998

Miki T, Nagashima K, Tashiro F, Kotake K, Yoshitomi H, Tamamoto A, Gonoi T, Iwanaga T, Miyazaki J, Seino S:
Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice.
Proc. Natl. Acad. Sci. USA. 95:10402-10406, 1998

Sanchez JA, Gonoi T, Inagaki N, Katada T, Seino S:
Modulation of reconstituted ATP-sensitive K+-channels by GTP-binding proteins in a mammalian cell line.
J. Physiol. 507:315-324, 1998

Mizuno N, Yoshitomi H, Ishida H, Kuromi H, Kawaki J, Seino Y, Seino S:
Altered bcl-2 and bax expression and intracellular Ca2+ signaling in apoptosis of pancreatic cells and the impairment of glucose-induced insulin secretion.
Endocrinology 139:1429-1439, 1998

Gribble FM, Tucker SJ, Seino S, Ashcroft FM:
Tissue specificity of sulfonylureas: studies on cloned cardiac and beta-cell KATP channels.
Diabetes 47:1412-1418, 1998

このページの先頭へ

1997

Miki T, Tashiro F, Iwanaga T, Nagashima K, Yoshitomi H, Aihara H, Nitta Y, Gonoi T, Inagaki N, Miyazaki J, Seino S:
Abnormalities of pancreatic islets by targeted expression of a dominant-negative KATP channel.
Proc. Natl. Acad. Sci. USA 94:11969-11973, 1997

Kotake K, Ozaki N, Mizuta M, Sekiya S, Inagaki N, Seino S:
Noc2, a putative zinc finger protein involved in exocytosis in endocrine cells.
J. Biol. Chem. 272:29407-29410, 1997

Inagaki N, Gonoi T, Seino S:
Subunit stoichiometry of the pancreatic beta-cell ATP-sensitive K+ channel.
FEBS lett. 409:232-236, 1997

Mizuta M, Kurose T, Miki T, Shoji-Kasai Y, Takahashi M, Seino S, Matsukura S:
Localization and functional role of synaptotagminIII in insulin secretory vesicles in pancreatic beta-cells.
Diabetes 46:2002-2006, 1997

Ueda K, Inagaki N, Seino S:
Mg ADP Antagonism to Mg2+-independent ATP binding of the sulfonylurea receptor SUR1.
J. Biol. Chem. 272:22983-22986, 1997

Dunne MJ, Kane C, Shepherd RM, Sanchez JA, James RFL, Johnson PRV, Aynsley-Green A, Lu S, Clement IV,JP, Lindley KJ, Seino S, Aguilar-Bryan L:
Familial persistent hyperinsulinemic hypoglycemia of infancy, and mutations in the sulfonylurea receptor.
New Engl. J. Med. 336:703-706, 1997

Nestorowicz, A., Inagaki N., Gonoi, T., Schoor, K.P., Wilson, B.A., Glaser, B., Landau, H.,Stanley,C.A., Thornton P.S., Seino,S. and Permutt, M.A:
A nonsense mutation in the inward rectifier potassium channel gene, Kir6.2, is associated with familial hyperinsulinism.
Diabetes 46:1743-1748, 1997

Suzuki, M., Fujikura, K., Inagaki, N., Seino,S. and Takata, K:
Localization of the ATP-sensitive K+ channel subunit, Kir6.2, in mouse pancreas.
Diabetes 46:1440-1444, 1997

このページの先頭へ

1996

Inagaki N, Gonoi T, Clement IV,JP, Wang C-Z, Aguilar-Bryan L, Bryan J, Seino, S:
A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels.
Neuron 16:1011-1017, 1996

Yoshitomi, H., Fujii, Y., Miyazaki, M., Nakajima, N., Inagaki, N. and Seino, S:
Involvement of MAP kinase and c-fos signaling in the inhibition of cell growth by somatostatin.
Am. J. Physiol. Endocrinol. Metab. 272:E769-E774, 1997

Namba, N., Inagaki, N., Gonoi, T., Seino, Y. and Seino, S:
Kir2.2v : a possible negative regulator of the inwardly rectifying K+ channel Kir2.2.
FEBS lett. 386:211-214, 1996

このページの先頭へ

1995

Inagaki N, Gonoi T, Clement IV, JP, Namba N, Inazawa J, Gonzalez G, Aguilar-Bryan L, Seino S, Bryan J:
Reconstitution of IKATP: An inward rectifier subunit plus the sulfonylurea receptor.
Science 270:1166-1170, 1995

Inagaki N, Tsuura Y, Namba N, Masuda K, Gonoi T, Horie M, Seino Y, Mizuta M, Seino S:
Cloning and functional characterization of a novel ATP-sensitive potassium channel ubiquitously expressed in rat tissues, including pancreatic islets, pituitary, skeletal muscle, and heart.
J. Biol. Chem. 270:5691-5694, 1995

Ihara, Y., Yamada, Y., Fujii, Y., Gonoi, T., Yano, H., Yasuda, K., Inagaki, N., Seino, Y. and Seino, S:
Molecular diversity and functional characterization of voltage-dependent calcium channels (CACN4) expressed in pancreatic β-cells.
Mol. Endocrinol. 9:121-130, 1995

Inagaki, N., Kuromi, H., Gonoi, T., Okamoto, Y., Ishida, H., Seino, Y., Kaneko, T., Iwanaga, T. and Seino, S:
Expression and role of ionotropic glutamate receptors in pancreatic islet cells.
FASEB J. 9:686-691, 1995

Kuromi, H., Mizuno, N. and Seino, S:
A monitor of secretion from single pancreatic β-cells.
Diabetes 44:1213-1217, 1995

Yamada, Y., Hayami, T., Nakamura, K., Kaisaki, P., Someya, Y., Wang, C-Z., Seino, S. and Seino, Y:
Human gastric inhibitory polypeptide receptor: cloning of gene and cDNA.
Genomics 29:773-776, 1995

Inagaki, N., Inazawa, J.and Seino, S.:
cDNA sequence, gene structure, and chromosomal localization of the human ATP-sensitive potassium channel, uKATP-1, Gene (KCNJ8).
Genomics 30:102-104, 1995

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