Division of Molecular and Metabolic Medicine
Kobe University Graduate School of Medicine
神戸大学大学院 医学研究科 分子代謝医学分野
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Kobe University School of Medicine

Professor Susumu Seino’s Lab.

Division of Molecular and Metabolic Medicine
Department of Physiology and Cell Biology
Kobe University Graduate School of Medicine

location
Kobe Biotechnology Research and Human Resource Development Center
1-5-6 Minatojimaminamimachi, Chuo-ku, Kobe 650-0047, JAPAN
Tel: +81-78-304-6061
Fax: +81-78-304-6064
E-mail: seino@med.kobe-u.ac.jp


Research Summary

Insulin secretion from pancreatic β-cells is crucial in the maintenance of glucose homeostasis, and failures of the regulation of insulin secretion cause diabetes and hypoglycemia. Research in our laboratory has been centered on the broad questions of 1) how insulin secretion is regulated at molecular, cellular, and whole organism levels; 2) what the relationship is, between abnormalities of cell signaling in pancreatic β-cells and diabetes; 3) how β-cells are regenerated in vivo and in vitro; and 4) how we can develop novel strategies targeting pancreatic β-cells for diabetes. Our final goal is to understand physiology of pancreatic β-cells, to clarify mechanisms of diabetes, and to develop its innovative treatment, utilizing various approaches including biochemistry, molecular biology, cell biology, physiology, and molecular genetics.

Project 1: Mechanisms of cell signaling in insulin secretion
a) Identification of molecular basis of target and regulators of major signals in insulin secretion
b) Clarification of the physiological roles of the identified target and regulators by genetic manipulation
c) New approach to clarification of mechanisms of cell signaling in insulin secretion
Project 2: Regenerative medicine of pancreatic β-cells
a) In vitro generation of insulin-secreting cells from exocrine pancreas
b) Identification of endogenous pancreatic stem/progenitor cells
Project 3: Identification of genes responsible for diabetes
a) KDP rat study: Identification of modifier genes involved in type 1 diabetes
b) SDT rat study: Identification of genes involved in diabetes and inflammation and fibrosis in the pancreas
c) CBLB study: Identification and functional analysis of CBLB mutations in type 1 diabetes
d) Human study: Identification of genes involved in pancreatic β-cell function
Project 4: Cell therapy for diabetes with inflammation in pancreatic islets
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