研究業績


代表的な英文業績 (2007年〜2011年)
2011
Fukuda M, Naka M, Mizokami J, Negi A, Nakamura M: Diabetes induces expression of aquaporin-0 in the retinal nerve fibers of spontaneously diabetic Torii rats. Exp Eye Res. 2011;92:195-201.
Kusuhara S, Ooto S, Kimura D, Itoi K, Mukuno H, Miyamaoto N, Akimoto M, Takagi H: Intraocular gas dynamics after 20-gauge and 23-gauge vitrectomy with sulfur hexafluoride gas tamponade. Retina 2011;31:250-6.

2010
Otsuka H, Arimura N, Sonoda S, Nakamura M, Hashiguchi T, Maruyama I, Nakao S, Hafezi-Moghadam A, Sakamoto T:Stromal cell-derived factor 1 is essential for photoreceptor cell protection in retinal detachment. Am J Pathol.177: 2268-2277. 2010.
Fukuda M, Nakanishi Y, Fuse M, Yokoi N, Hamada Y, Fukagawa M, Negi A, Nakamura M:Altered expression of aquaporins 1 and 4 coincides with neurodegenerative events in retinas of spontaneously diabetic Torii rats. Exp Eye Res. 90:17-25. 2010.
Honda S, Nagai T, Kondo N, Fukuda M, Kusuhara S, Tsukahara Y, Negi A:Therapeutic effect of oral bisphosphonates on choroidal neovascularization in the human eye. J Ophthalmol. Volume 2010: 7. 2010.
Haruta M, Mukuno H, Nishijima K, Takagi H, Kita M. Sympathetic ophthalmia after 23-gauge transconjunctival sutureless vitrectomy.Clin Ophthalmol.22:1347-1349. 2010.
Tagami M, Kusuhara S, Imai H, Uemura A, Honda S, Tsukahara Y, Negi A:MRP4 knockdown enhances migration, suppresses apoptosis, and produces aggregated morphology in human retinal vascular endothelial cells. Biochem Biophys Res Commun. 400:593-598. 2010.
Matsumiya W, Honda S, Imai H, Kusuhara S, Tsukahara Y, Negi A:A Case of Bilateral Macular Holes Showing Onset and Spontaneous Closure over Very Short Intervals. Case Report Ophthalmol. 13;1:47-52. 2010.
Miki A, Miki K, Ueno S, Wersinger DM, Berlinicke C, Shaw GC, Usui S, Wang Y,Zack DJ, Campochiaro PA. Prolonged blockade of VEGF receptors does not damage retinal photoreceptors or ganglion cells. J Cell Physiol 2010;224:262-72.
Naka M, Kanamori A, Negi A, Nakamura M:Reduced expression of aquaporin-9 in rat optic nerve head and retina following elevated intraocular pressure. Invest Ophthalmol Vis Sci. 51: 4618-4626. 2010.
Mizokami J,Yamada Y, Negi A,Nakamura M Postural changes of intraocular pressure affect the inter-eye difference both in visual field damage and retinal nerve fiber layer thickness reduction in the same patients with primary open-angle glaucoma Graefes Arch. Clin.Exp.Ophthalmol. 21;2010
Kakutani Y, Nakamura M, Nagai-Kusuhara A, Kanamori A, Negi A:Marked cup reversal presumably associated with scleral biomechanics in a case of adult glaucoma. Arch Ophthalmol 128:139-141. 2010.
Murakami K, Meguro A, Ota M, Shiota T, Nomura N, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M, Negi A, Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, Higashide T, Sugiyama K, Kanamoto T, Kiuchi Y, Iwase A, Ohno S, Inoko H, Mizuki N:Analysis of microsatellite polymorphisms within the GLC1F locus in Japanese patients with normal tension glaucoma. Mol Vis. 16: 462-466. 2010.
Suzuki M, Meguro A, Ota M, Nomura E, Kato T, Nomura N, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M, Negi A, Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, Higashide T, Sugiyama K, Kanamoto T, Kiuchi Y, Iwase A, Ohno S, Inoko H, Mizuki N. Genotyping HLA-DRB1 and HLA-DQB1 alleles in Japanese patients with normal tension glaucoma. Mol Vis. 15:1874-9.2010.
The writing committee for the normal tension glaucoma genetic study group of Japan Glaucoma Society. Genome-wide association study of normal tension glaucoma: Common variants in SRBD1 and ELOLV5 contribute to disease susceptibility. Ophthalmology 117: 1331-1338. 2010.
Kanamori A, Catrinescu MM, Kanamori N, Mears KA, Beaubien R, Levin LA:Superoxide is an associated signal for apoptosis in axonal injury. Brain. 133:2612-2625. 2010.
Kanamori A, Catrinescu MM, Mahammed A, Gross Z, Levin LA:Neuroprotection against superoxide anion radical by metallocorroles in cellular and murine models of optic neuropathy. J Neurochem. 114:488-498. 2010.
Kanamori A,Catrinescu MM, Traistaru M, Beaubien R, Levin LA:In vivo imaging of retinal ganglion cell axons within the nerve fiber layer. Invest Ophthalmol Vis Sci. 51: 2011-2018. 2010.
Fujioka K ,Morioka I, Nozu K,,Nishimoto M, Amano M, Tagami M, Honda S, Yokoyama N, Yamada H, Iijima K and Matsuo M:A surviving case of papillorenal syndrome with the phenotype of Potter sequence. Pediatrics International 2010. In press.
Tagami M, Honda S, Morioka I, Matsuo M, Negi A:Bilateral Optic Disc Anomalies Associated with PAX2 Mutation in a Case of Potter Sequence. Case Report Ophthalmol.1:94-98. 2010.
Hirabayashi H, Honda S,MoriokaI, Yokoyama N, Sugiyama D, Nishimura K, Matsuo M, Negi A.Inhibitory effectsof maternal smoking on the development of severe retinopathy of prematurity.Eye 2010;24:1024-7.

2009

Kondo N, Bessho H, Honda S, Negi A.SOD2 genepolymorphisms in neovascular age-related macular degeneration and polypoidalchoroidal vasculopathy.Mol Vis. 2009;15:1819-26.

Fukuda M, Nakanishi Y,Fuse M, Yokoi N, Hamada Y, Fukagawa M,NegiA, Nakamura M. Altered expression of aquaporins 1 and 4 coincides withneurodegenerative events of spontaneously diabetic Torii rats. Exp Eye Res2010;90;17-25.
Sekimukai D, Honda S, Negi A.RNA interferencefor apoptosis signal-regulating kinase-1 (ASK-1) rescues photoreceptor death inthe rd1 mouse.Mol Vis.2009;15:1764-73.
Nakamura K, Ota M, Meguro A, Nomura N, Kashiwagi K, Mabuchi F,Iijima H, Kawase K, Yamamoto T, Nakamura M, Negi A, Sagara T, Nishida T,Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, Higashide T,Sugiyama K, Kanamoto T, Kiuchi Y, Iwase A, Ohno S, Inoko H, Mizuki N.Association ofmicrosatellite polymorphisms of the GPDS1 locus with normal tension glaucoma inthe Japanese population.Clin Ophthalmol. 2009;3:307-12.
Imai H, SinghRS,FortPE, Gardner TW, Neuroprotection fordiabetic retinopathy: Pharmacology and vitreoretinal surgery (Review), DevOphthalmol. Karger, 2009;44:56-68.
Fort PE, ImaiH, Rajala R, Gardner TW, Insulin Signaling in Normal and Diabetic Conditions (Bookchaptor), Signal Transduction: Pathways, Mechanisms and Diseases. Springer, 2009;101-118.
Honda S,Kurimoto Y, Kagotani Y, Yamamoto H, Takagi H, Uenishi M; Hyogo Macular DiseaseStudy Group., Photodynamic therapy for typical age-related macular degenerationand polypoidal choroidal vasculopathy: a 30-month multicenter study inHyogo,Japan.Jpn J Ophthalmol. 2009;53(6):593-597.
Kamio M, Meguro A, Ota M, Nomura N, Kashiwagi K, Mabuchi F, IijimaH, Kawase K, Yamamoto T, Nakamura M, Negi A, Sagara T, Nishida T, Inatani M,Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, Higashide T, Sugiyama K,Kanamoto T, Kiuchi Y, Iwase A, Ohno S, Inoko H, Mizuki N.Investigation ofthe association between the GLC3A locus and normal tension glaucoma in Japanesepatients by microsatellite analysis.ClinOphthalmol. 2009;3:183-8.
Kondo N, Honda S, Kuno S, Negi A.Role of RDBP andSKIV2L variants in the major histocompatibility complex class III region inpolypoidal choroidal vasculopathy etiology.Ophthalmology. 2009;116(8):1502-9.
Kanamori A, Naka M, Fukuda M, Nakamura M, Negi A.Tafluprost protectsrat retinal ganglion cells from apoptosis in vitro and in vivo.Graefes Arch Clin Exp Ophthalmol. 2009;247(10):1353-60.
Imago M, ImaiH, Nakanishi Y, Azumi A, Optical coherence tomography for monitoring theprocess of Candida endophthalmitis. Acta Ophthalmol. 2009;87(6):680-682.
Naka M,Kanamori A, Tatsumi Y, Fujioka M, Nagai-Kusuhara A, Nakamura M, Negi A.Comparison of meandeviation with AGIS and CIGTS scores in association with structural parametersin glaucomatous eyes.J Glaucoma. 2009;18(5):379-84.
Tagami M, Kusuhara S, Honda S, Tsukahara Y, NegiA.Expression of ATP-binding cassette transporters at the innerblood-retinal barrier in a neonatal mouse model of oxygen-induced retinopathy.Brain Res.2009;1283:186-93.
Bessho H, Kondo N, Honda S, Kuno S, NegiA.Coding variantMet72Thr in the PEDF gene and risk of neovascular age-related maculardegeneration and polypoidal choroidal vasculopathy.Mol Vis. 2009;15:1107-14.
Honda S, Imai H, Yamashiro K, KurimotoY, Kanamori-Matsui N, Kagotani Y, Tamura Y, Yamamoto H, Ohoto S, Takagi H,Uenishi M, Negi A. Comparativeassessment of photodynamic therapy for typical age-related macular degenerationand polypoidal choroidal vasculopathy: a multicenter study in Hyogo prefecture,Japan.Ophthalmologica.2009;223:333-8.
Kondo N, Honda S, Kuno S, Negi A.Coding variantI62V in the complement factor H gene is strongly associated with polypoidalchoroidal vasculopathy.Ophthalmology. 2009;116:304-10.
Nagai-Kusuhara A, Nakamura M, KanamoriA, Negi A.Association ofoptic disc configuration and clustered visual field sensitivity in glaucomatouseyes with hemifield visual field defects.J Glaucoma. 2009;18:62-8.
Nakamura M, Kanamori A, Nagai-Kusuhara A, Kusuhara S, Yamada Y, NegiA.Serous maculardetachment due to diabetic papillopathy detected using optical coherence tomography.Arch Ophthalmol. 2009;127:105-7.
Kanamori A, Naka M, Fukuda M, Nakamura M, Negi A.Latanoprostprotects rat retinal ganglion cells from apoptosis in vitro and in vivo.Exp Eye Res. 2009;88:535-41.
Honda S, Nagai T, Negi A.Anti-angiogeniceffects of non-peptide integrin alphavbeta3 specific antagonist onlaser-induced choroidal neovascularization in mice.Graefes Arch Clin Exp Ophthalmol. 2009;247:515-22.
2008
Ooto S, Kimura D, Itoi K, Mukuno H, Kusuhara S, Miyamoto N,Akimoto M, Takagi H.Suprachoroidalfluid as a complication of 23-gauge vitreous surgery.Br J Ophthalmol. 2008;92:1433-4.
Kusuhara S, Ooto S, Kimura D, Itoi K, Mukuno H, Miyamoto N,Akimoto M, Kuriyama S, Takagi H.Outcomes of 23-and 25-gauge transconjunctival sutureless vitrectomies for idiopathic macularholes.Br J Ophthalmol.2008;92:1261-4.
Kanamori A, Naka M, Nagai-Kusuhara A,Yamada Y, Nakamura M, Negi A.Regionalrelationship between retinal nerve fiber layer thickness and correspondingvisual field sensitivity in glaucomatous eyes.ArchOphthalmol. 2008;126:1500-6.
Imai H,Azumi A, Nagai T, Yamamoto H, Negi A, Ohbayashi C, A case of oculartoxoplasmosis: Direct proof of the protozoan infection by retinal biopsy.Retinal cases and brief reports. 2008;2(1): 76-79.
Sakamoto T, Hida T, Tano Y, Negi A, Takeuchi S, Ishibashi T, InoueY, Ohguro N, Okada AA; Committee for Silicone Oil for Ocular Disease. Survey ofsilicone oil for ocular diseases inJapan.NipponGanka Gakkai Zasshi.2008;112:790-800.
Tagami M, Kusuhara S, Honda S,Tsukahara Y, Negi A.Rapid regressionof retinal hemorrhage and neovascularization in a case of familial exudativevitreoretinopathy treated with intravitreal bevacizumab.Graefes Arch Clin Exp Ophthalmol.2008;246:1787-9.
Darhad U, Nakamura M, Fujioka M,Tatsumi Y, Nagai-Kusuhara A, Maeda H, Negi A.Intraocularpressure lowering effect of once daily versus once weekly latanoprostinstillation in the same normal individuals.Kobe JMed Sci. 2008;53:297-304.
Akiyama M, Yatsu K, Ota M, Katsuyama Y,Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M, Negi A,Sagara T, Kumagai N, Nishida T, Inatani M, Tanihara H, Ohno S, Inoko H, MizukiN.Microsatelliteanalysis of the GLC1B locus on chromosome 2 points to NCK2 as a new candidategene for normal tension glaucoma.Br J Ophthalmol. 2008;92:1293-6.
Tatsumi Y,Kanamori A, Nagai-Kusuhara A, Nakanishi Y, Agarwal N, Negi A, Nakamura M.Nipradilolprotects rat retinal ganglion cells from apoptosis induced by serum deprivationin vitro and by diabetes in vivo.Curr Eye Res. 2008;33:683-92.
Nagai-Kusuhara A,Nakamura M, Tatsumi Y, Nakanishi Y, Negi A.Disagreementbetween Heidelberg Retina Tomograph and optical coherence tomography inassessing optic nerve head configuration of eyes with band atrophy and normaleyes.Br J Ophthalmol. 2008;92:1382-6.
Shibuya E, Meguro A, Ota M, Kashiwagi K, Mabuchi F, Iijima H,Kawase K, Yamamoto T, Nakamura M, Negi A, Sagara T, Nishida T, Inatani M,Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, Higashide T, Sugiyama K,Kanamoto T, Kiuchi Y, Iwase A, Ohno S, Inoko H, Mizuki N.Association ofToll-like receptor 4 gene polymorphisms with normal tension glaucoma.Invest Ophthalmol Vis Sci. 2008;49:4453-7.
Kondo N, Honda S,Ishibashi K, Tsukahara Y, Negi A.Elastin genepolymorphisms in neovascular age-related macular degeneration and polypoidalchoroidal vasculopathy.Invest Ophthalmol Vis Sci. 2008;49:1101-5.
Honda S, Hirabayashi H, Tsukahara Y, Negi A.Acute contractionof the proliferative membrane after an intravitreal injection of bevacizumabfor advanced retinopathy of prematurity.GraefesArch Clin Exp Ophthalmol. 2008;246:1061-3.
Inatani M, Iwao K, Kawaji T, Hirano Y, Ogura Y, Hirooka K, ShiragaF, Nakanishi Y, Yamamoto H, Negi A, Shimonagano Y, Sakamoto T, Shima C,Matsumura M, Tanihara H.Intraocularpressure elevation after injection of triamcinolone acetonide: a multicenterretrospective case-control study.Am J Ophthalmol. 2008;145:676-681.
Sakamoto T, Hida T, Tano Y, Negi A,Takeuchi S, Ishibashi T, Inoue Y, Ohguro N, Okada AA; Committee on the Use ofLong-lasting Expanding Gases in Ophthalmology. Survey of the use oflong-lasting expanding gases in ophthalmology in Japan.NipponGanka Gakkai Zasshi. 2008;112:45-50.

Nagai-Kusuhara A, Nakamura M, FujiokaM, Tatsumi Y, Negi A.Association ofretinal nerve fibre layer thickness measured by confocal scanning laserophthalmoscopy and optical coherence tomography with disc size and axiallength.Br J Ophthalmol.2008;92:186-90.

SakamotoT, Hida T, Tano Y, Negi A, Takeuchi S, Ishibashi T, Inoue Y, Ohguro N, OkadaAA; Committee for Triamcinolone Acetonide for Ocular Disease in Japan. Surveyof triamcinolone acetonide for ocular diseases in Japan.NipponGanka Gakkai Zasshi. 2007;111:936-45.

Nagai-Kusuhara A, Nakamura M, Fujioka M, Negi A.Long-term resultsof amniotic membrane transplantation-assisted bleb revision for leaking blebs.Graefes Arch Clin Exp Ophthalmol.2008;246:567-71.
2007
Nagai T, Imai H,Honda S, Negi A.Antiangiogeniceffects of bisphosphonates on laser-induced choroidal neovascularization inmice.Invest Ophthalmol Vis Sci. 2007;48:5716-21.
Imai H, Honda S, Kondo N, Ishibashi K,Tsukahara Y, Negi A.The upregulationof angiogenic gene expression in cultured retinal pigment epithelial cellsgrown on type I collagen.Curr Eye Res. 2007;32:903-10.
Ishikawa K, HondaS, Tsukahara Y, Negi A.Preferable use ofintravitreal bevacizumab as a pretreatment of vitrectomy for severeproliferative diabetic retinopathy.Eye. 2009;23:108-11.
Kondo N, Honda S, Ishibashi K, Tsukahara Y, Negi A.LOC387715/HTRA1variants in polypoidal choroidal vasculopathy and age-related maculardegeneration in a Japanese population.Am JOphthalmol. 2007;144:608-12.
Tsukahara Y, Honda S, Imai H, Kondo N, Fujii S, Yokoyama N, HirataA, Kawaji T, Fukushima M, Tanihara H, Negi A. Autologousplasmin-assisted vitrectomy for stage 5 retinopathy of prematurity: apreliminary trial.Am J Ophthalmol. 2007;144:139-41.

Nagai-Kusuhara A,Nakamura M, Kanamori A, Nakanishi Y, Kusuhara S, Negi A.Evaluation ofoptic nerve head configuration in various types of optic neuropathy withHeidelberg Retina Tomograph.Eye. 2008;22:1154-60.

Fujioka M, Nakamura M, Tatsumi Y, Kusuhara A, Maeda H, Negi A.Comparison ofPentacam Scheimpflug camera with ultrasound pachymetry and noncontact specularmicroscopy in measuring central corneal thickness.CurrEye Res. 2007;32:89-94.
Nagai-Kusuhara A,Nakamura M, Mukuno H, Kanamori A, Negi A, Seigel GM.cAMP-responsiveelement binding protein mediates a cGMP/protein kinase G-dependentanti-apoptotic signal induced by nitric oxide in retinal neuro-glial progenitorcells.Exp Eye Res. 2007;84:152-62.
Tatsumi Y,Nakamura M, Fujioka M, Nakanishi Y, Kusuhara A, Maeda H, Negi A.Quantification ofretinal nerve fiber layer thickness reduction associated with a relativeafferent pupillary defect in asymmetric glaucoma.Br J Ophthalmol.2007;91:633-7.