本文へスキップ

神戸大学大学院医学研究科 生理学・細胞生物学講座 システム生理学分野

TEL: 078-382-5805

〒650-0017 神戸市中央区楠町7-5-1

Publications

研究業績

1. Miyamoto A, Wake H, Ishikawa AW, Eto K, Shibata K, Murakoshi H, Koizumi S, Moorhouse AJ, Yoshimura Y, Nabekura J.Microglia contact induces synapse formation in developing somatosensory cortex.
Nat Commun. 2016. (In press)

2. Kato G, Inada H, Wake H, Akiyoshi R, Miyamoto A, Eto K, Ishikawa T, Moorhouse AJ, Strassman A, Nabekura J. Microglial Contact Prevents Excess Depolarization and Rescues Neurons from Excitotoxicity. eNeuro. 2016. (In press)

3. Wake H, Ortiz FC, Woo DH, Lee PR, Angulo MC, Fields RD. Nonsynaptic junctions on myelinating glia promote preferential myelination of electrically active axons.
Nat Commun. 2015 Aug 4;6:7844.

4. Wake H, Kato D. Frontiers in Live Bone Imaging Researches. In vivo imaging of neuron and glia.
Clin Calcium. 2015;25(6):859-70. doi: CliCa1506859870. Japanese.

5. Wake H, Kato D. Brain function and white matter.
Brain Nerve. 2015 Apr;67(4):505-12. Japanese.

6. Sierra A, Tremblay ME, Wake H. Never-resting microglia: physiological roles in the healthy brain and pathological implications.
Front Cell Neurosci. 2014 Aug 15;8:240.

7. Wake H. The mechanism for activity dependent regulation of myelin.
Seikagaku. 2013 Nov;85(11):999-1002. Review. Japanese.

8. Fields RD, Araque A, Johansen-Berg H, Lim SS, Lynch G, Nave KA, Nedergaard M, Perez R, Sejnowski T, Wake H. Glial biology in learning and cognition.
Neuroscientist. 2014 Oct;20(5):426-31.

9. Miyamoto A, Wake H, Moorhouse AJ, Nabekura J. Microglia and synapse interactions: fine tuning neural circuits and candidate molecules.
Front Cell Neurosci. 2013 May 15;7:70.

10. Wake H, Moorhouse AJ, Miyamoto A, Nabekura J. Microglia: actively surveying and shaping neuronal circuit structure and function.
Trends Neurosci. 2013 Apr;36(4):209-17.

11. Toyoda T, Matsukawa N, Sagisaka T, Uematsu N, Kanamori T, Kato D, Mizuno M, Wake H, Hida H, Borlongan CV, Ojika K. Suppression of astrocyte lineage in adult hippocampal progenitor cells expressing hippocampal cholinergic neurostimulating Peptide precursor in an in vivo ischemic model.
Cell Transplant. 2012;21(10):2159-69.

12. Leung JY, Bennett WR, Herbert RP, West AK, Lee PR, Wake H, Fields RD, Chuah MI, Chung RS. Metallothionein promotes regenerative axonal sprouting of dorsal root ganglion neurons after physical axotomy.
Cell Mol Life Sci. 2012 Mar;69(5):809-17.

13. Wake H, Fields RD. Physiological function of microglia.
Neuron Glia Biol. Feb;7(1):1-3. 2011

14. Inada H, Watanabe M, Uchida T, Ishibashi H, Wake H, Nemoto T, Yanagawa Y, Fukuda A, Nabekura J. GABA regulates the multidirectional tangential migration of GABAergic interneurons in living neonatal mice. PLoS One. 2011;6(12):e27048.

15. Wake H, Moorhouse AJ, Nabekura J. Functions of microglia in the central nervous system--beyond the immune response.
Neuron Glia Biol. 2011 Feb;7(1):47-53. Review.

16. Tremblay ME, Stevens B, Sierra A, Wake H, Bessis A, Nimmerjahn A. The role of microglia in the healthy brain.
J Neurosci. 2011 Nov 9;31(45):16064-9. Review.

17. Wake H, Lee PR, Fields RD. Control of local protein synthesis and initial events in myelination by action potentials.
Science. 2011 Sep 16;333(6049):1647-51.

18. Eto K, Wake H, Watanabe M, Ishibashi H, Noda M, Yanagawa Y, Nabekura J. Inter-regional contribution of enhanced activity of the primary somatosensory cortex to the anterior cingulate cortex accelerates chronic pain behavior.
J Neurosci. 2011 May 25;31(21):7631-6.

19. Sawada M, Kaneko N, Inada H, Wake H, Kato Y, Yanagawa Y, Kobayashi K, Nemoto T, Nabekura J, Sawamoto K. Sensory input regulates spatial and subtype-specific patterns of neuronal turnover in the adult olfactory bulb.
J Neurosci. 2011 Aug 10;31(32):11587-96.

20. Sagisaka T, Matsukawa N, Toyoda T, Uematsu N, Kanamori T, Wake H, Borlongan CV, Ojika K. Directed neural lineage differentiation of adult hippocampal progenitor cells via modulation of hippocampal cholinergic neurostimulating peptide precursor expression.
Brain Res. 2010 Apr 23;1327:107-17.

21. Marumo T, Eto K, Wake H, Omura T, Nabekura J. The inhibitor of 20-HETE synthesis, TS-011, improves cerebral microcirculatory autoregulation impaired by middle cerebral artery occlusion in mice.
Br J Pharmacol. 2010 Nov;161(6):1391-402.

22. Watanabe M, Wake H, Moorhouse AJ, Nabekura J. Clustering of neuronal K+-Cl-cotransporters in lipid rafts by tyrosine phosphorylation.
J Biol Chem. 2009 Oct 9;284(41):27980-8.

23. Wake H, Moorhouse AJ, Jinno S, Kohsaka S, Nabekura J. Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals.
J Neurosci. 2009 Apr 1;29(13):3974-80.

24. Iohara K, Zheng L, Wake H, Ito M, Nabekura J, Wakita H, Nakamura H, Into T, Matsushita K, Nakashima M. A novel stem cell source for vasculogenesis in ischemia: subfraction of side population cells from dental pulp.
Stem Cells. 2008 Sep;26(9):2408-18.

25. Wake H. KCC2 phosphorylation in injured brain.
Bulletin of the Japanese Society for Neurochemistry Vol47(No.1) pp31-35 2008

26. Wake H, Watanabe M, Moorhouse AJ, Kanematsu T, Horibe S, Matsukawa N, Asai K, Ojika K, Hirata M, Nabekura J. Early changes in KCC2 phosphorylation in response to neuronal stress result in functional downregulation.
J Neurosci
. 2007 Feb 14;27(7):1642-50.

27. Mizoguchi Y, Kitamura A, Wake H, Ishibashi H, Watanabe M, Nishimaki T, Nabekura J. BDNF occludes GABA receptor-mediated inhibition of GABA release in rat hippocampal CA1 pyramidal neurons.
Eur J Neurosci. 2006 Oct;24(8):2135-44.



Division of System Neuroscience

Kobe University of Graduate School of Medicine


神戸大学大学院医学研究科 生理学・細胞生物学講座 システム生理学分野

〒650-0017
神戸市中央区楠町7-5-1
TEL 078-382-5805
FAX 078-382-5806