Yoshitake Hayashi MD, PhD

Office

International Center for Medical Research and Treatment (ICMRT), Kobe University Graduate School of Medicine.
7-5-1, Kusunoki-cho, Chuo-ku, Kobe 650-0017 Japan
hayashiy@med.kobe-u.ac.jp

Brief Summary of a Career

1985AprilResearch Staff, Cancer Institute, Tokyo
1986AprilAssistant Professor, Tokyo University
1988MarPh.D. (Tokyo University)
1992JanAssociate Professor, Kobe University
2003AprilProfessor, Kobe University

Research Field

Molecular Medicine and Medical Genetics

Research Activities

Main project is to establish the international network against world-wide spread of emerging and reemerging infections, particularly in systematic and politico-economical aspects. As an education for PhD students, molecular and genetic research of infectious diseases and diabetes mellitus, liver, biliary duct and pancreatic diseases, and cardiovascular diseases are being carried out. Diagnostic pathology of lymph-nodes and hematopoietic diseases, and genomic polymorphism and mutation of hepatitis virus (Hepatitis B virus, Hepatitis C virus and Hepatitis E virus) are being researched.

Main Publication

Surgical and Anatomical Pathology of Liver Diseases
• Various scoring systems evaluating histological features of chronic hepatitis C after IFN therapy (Hum Pathol 32:910-917, 2001)

Molecular Pathology of Liver Diseases and Molecular Biology of Hepatocytes
• Identification and characterization of two enhancers of the human albumin gene (J Biol Chem. 267:14580-14585, 1992)
• Quantitation of Hepatitis C Viral RNA in Liver Tissues and Sera by Competitive PCR: Relationship with Response to Interferon Alpha Treatment. (J Clin Pathol, 48:820-825, 1995)
  
• Expression Ratio of Hepatocyte Nuclear Factor-1 and Its Variant is Linked to Differentiation of Hepatocytic Neoplasms. (J Hepatol, 25:445-453, 1996)
• Expression of Urokinase-type Plasminogen Activator Receptor in Hepatocellular Carcinoma (Hepatol 25:856-861, 1997)
• Expression of HNF-1a and HNF-1b in Various Histological Differentiations of Hepatocellular Carcinoma (J Pathol 184:272-278, 1998)
• Genomic aberrations in human hepatocellular carcinomas of differing etiologies (Clinical Cancer Res 6: 4000-4009, 2000)
• Regulation of the alpha-fetoprotein gene by the isoforms of ATBF1 transcription factor in human hepatoma (Hepatol 35:82-87, 2002)
• Down-regulation of stomach cancer−associated protein tyrosine phosphatase−1 (SAP-1) in advanced human hepatocellular carcinoma (Oncogene 22:4656-4663, 2003)
• Protein kinase Cl in liver mediates insulin-induced SREBP-1c expression and determine both hepatic lipid content and overall insulin sensitivity. (J Clin Investigation 112:935-944, 2003)
• Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice. (Nature Medicine 11(2):175 - 182, 2005)
• The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity. (J Clin Investigation 116(9):2473-83, 2006)
• Forkhead transcription factor FoxO1 in adipose tissue regulates energy storage and expenditure. (Diabetes 57(3):563-576, 2008)