業績
      
 
2017年, 2016年, 2015年, 2014年,2013年, 2012年, 2011年, 2010年, 2009年, 2008年, 2007年, 2006年, 2005年, 2004年, 2003年, 2002年,2000年, 1999年, 1998年, 1997年, 1996年, 1995年, 1994年, 1993年, 1992年
2017年
Yoshikawa Y, Takano O, Kato I, Takahashi Y, Shima F, Kataoka T..
Ras inhibitors display an anti-metastatic effect by downregulation of lysyl oxidase through inhibition of the Ras-PI3K-Akt-HIF-1α pathway.
Sep 2017; 410: 82-91.
Cancer Lett.


Farag MI, Yoshikawa Y, Maeta K, Kataoka T..
Rapgef2, a guanine nucleotide exchange factor for Rap1 small GTPases, plays a crucial role in adherence junction (AJ) formation in radial glial cells through ERK-mediated upregulation of the AJ-constituent protein expression.
Sep 2017; 493(1): 139-145.
Biochem. Biophys. Res. Commun.


Matsunaga S., Hano Y., Fujimoto KJ., Kumasaka T., Matsumoto S., Kataoka T., Shima F., Tanaka S.
Structural transition of solvated H-Ras/GTP revealed by molecular dynamics simulation and local network entropy.
Jul 2017; 77: 51-63.
J. Mol. Graph. Model.


Ke H., Matsumoto S., Murashima Y., Taniguchi-Tamura H., Miyamoto R., Yoshikawa Y., Tsuda C., Kumasaka T., Mizohata E., Kataoka T.
Structural basis for intramolecular interaction of post-translationally modified H-Ras-GTP prepared by protein ligation.
Aug 2017; 591(16): 2470-2481
FEBS Lett.


2016年
Maeta K., Edamatsu H., Nishihara K., Ikutomo J., Bilasy SE., Kataoka T.
Crucial Role of Rapgef2 and Rapgef6, a Family of Guanine Nucleotide Exchange Factors for Rap1 Small GTPase, in Formation of Apical Surface Adherens Junctions and Neural Progenitor Development in the Mouse Cerebral Cortex.
Jun 2016; 3(3); ENEURO.0142-16:
eNeuro.


Matsumoto S., Miyano N., Baba S., Liao J., Kawamura T., Tsuda C., Takeda A.,
Yamamoto M., Kumasaka T., Kataoka T., Shima F.

Molecular Mechanism for Conformational Dynamics of Ras-GTP Elucidated from In-Situ Structural Transition in Crystal.
April 2016; 6; Article number: 25931
Scientific Reports.


Wakia M., Edamatsu H., Li M., Emi A., Kitazawa S., Kataoka T.
Phospholipase Cε Activates Nuclear Factor-kB Signaling by Causing Cytoplasmic Localization of Ribosomal S6 Kinase and Facilitating Its Phosphorylation of Inhibitor kB in Colon Epithelial Cells.
2016 June; 291(24), 12586-600.
J. Biol. Chem.


2015年
Shima, F., Matsumoto, S., Yoshikawa, Y., Kawamura, T., Isa, M., Kataoka, T.,
Current status of the development of Ras inhibitors.
2015 Aug;158(2):91-9.
J. Biochem.


2014年
Nagano T., Edamatsu H., Kobayashi K., Takenaka N., Yamamoto M., Sasaki N.,
Nishimura Y., Kataoka T.

Phospholipase Cε,an Effector of Ras and Rap Small GTPases,Is Required for Airway Inflammatory Response in a Mouse Model of Bronchial Asthma
September 2014, Volume 9, Issue 9, e108373
PLOS ONE.


2013年
Okada K., Miyake H., Yamaguchi K., Chiba K., Maeta K., E. Bilasy S.,
Edamatsu H., Kataoka T., Fujisawa M..

Critical function of RA-GEF-2/Rapgef6, a guanine nucleotide exchange factor for Rap1, in mouse spermatogenesis 2014;445:89-94
10.1016/j.bbrc.2014.01.149

Biochem. Biophys. Res. Commun.

島 扶美, 熊坂 崇, 松本 篤幸, 吉川, 陽子, 山本 雅貴, 片岡 徹
rasがん遺伝子産物の新規立体構造情報を利用した分子標的がん治療薬の開発
27(1) 3-9. 2014

日本放射光学会誌 放射光

Shima, F., and Kataoka, T.
Structure-based drug design of small-molecule Ras inhibitors having anti-tumor activity
.
2014
SPring-8 Research Frontiers

枝松 裕紀 , 片岡 徹
がん基盤生物学 - 革新的シーズ育成に向けて-
;142-146. 2013(南山堂)

Shima, F., Yoshikawa, Y., Matsumoto, S., Kataoka, T.,
Discovery of Small-Molecule Ras Inhibitors that Display Anti-tumor Activity by Interfering with Ras GTP-Effector Interaction. 2013; 34 : 1-24
Inhibitors of the Ras Superfamily G-proteins,Part B

THE ENZYMES
(Tamanoi,F.and Der,C.J.,eds.,Elsevier)

Shima, F., Yoshikawa, Y., Ye, M., Araki, M., Matsumoto, S., Liao, J., Hu, L., Sugimoto, T., Ijiri, Y., Takeda, A., Nishiyama, Y., Sato, C., Muraoka, S., Tamura, A., Osoda, T., Tsuda, K., Miyakawa, T., Fukunishi, H., Shimada, J., Kumasaka, T., Yamamoto, M., and Kataoka, T.
In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction.
2013 May 14;110(20):8182-7. doi: 10.1073/pnas.1217730110. Epub 2013 Apr 29.
Proc. Natl. Acad. Sci. USA.
2012年
Nozaki, S., Takeda, T., Kitaura, T., Takenaka, N., Kataoka, T., & Satoh, T.
Akt2 regulates Rac1 activity in the insulin-dependent signaling pathway leading to GLUT4 translocation to the plasma membrane in skeletal muscle cells.
Cell. Signal.2013Jun;25(6):1361-71./j.cellsig.2013.02.023. Epub 2013 Mar 14.

Nozaki, S., Ueda, S., Takenaka, N., Kataoka, T., & Satoh, T.
Role of RalA downstream of Rac1 in insulin-dependent glucose uptake in muscle cells.
Cell. Signal. 2012.24 (11): 2111-2117.586(12):1715-8.

Muraoka ,S., Shima,F., Araki,M., Inoue,T., Yoshimoto,A., Ijiri,Y., Seki,N., Tamura,A.,
Kumasaka,T., Yamamoto,M., & Kataoka,T.
Crystal structures of the state 1 conformations of the GTP-bound H-Ras protein and its
oncogenic G12V and Q61L mutants. (2012 May 11)
FEBS Lett. 586(12):1715-8.


2011年

Edamatsu, H., Takenaka, N., Hu, L., & Kataoka, T.
Phospholipase Ce as a potential molecular target for anti-inflammatory therapy and cancer prevention. (2011)
Inflamm. Regen. 31 (4): 370-374.

Harada, Y., Edamatsu, H., & Kataoka, T.
PLCe cooperates with the NF-kB pathway to augment TNFa-stimulated CCL2/MCP1 expression in human keratinocyte. (2011 Sep 7)
Biochem. Biophys. Res. Comm. 414: 106-111.

Araki M, Shima F, Yoshikawa Y, Muraoka S, Ijiri Y, Nagahara Y, Shirono T, Kataoka T, Tamura A.
Solution structure of the state 1 conformer of GTP-bound H-Ras protein and distinct dynamic properties between the state 1 and state 2 conformers.(2011 Nov 11
)
J Biol Chem.; 286(45):39644-53.

Bilasy, S. E., Satoh, T., Terashima, T., & Kataoka, T.
RA-GEF-1 (Rapgef2) is essential for proper development of the midline commissures. (2011Aug 4)
Neurosci. Res.; 71 (3): 200-209.
 

Matsumoto K, Shima F, Muraoka S, Araki M, Hu L, Ijiri Y, Hirai R, Liao J, Yoshioka T, Kumasaka T, Yamamoto M, Tamura A, Kataoka T.
Critical roles of interactions among switch I-preceding residues and between switch II and its neighboring {alpha}-helix on conformational dynamics of the GTP-bound Ras family small GTPases.(2011 Apr 29)
J Biol Chem.
;286(17):15403-12.
ここをクリックするとRas-GTPのスイッチの図が見られます。

Takenaka N, Edamatsu H, Suzuki N, Saito H, Inoue Y, Oka M, Hu L, Kataoka T.
Overexpression of phospholipase Cepsilon in keratinocytes upregulates cytokine expression and causes dermatitis with acanthosis and T-cell infiltration. (2011)
Eur J Immunol, 41(1):202-213
☆Takenaka et alの図が、European Journal of Immuonolgy誌の2011年1月号の表紙を飾りました。
(http://onlinelibrary.wiley.com/doi/10.1002/eji.v41.1/issuetoc)

Oka M, Edamatsu H, Kunisada M, Hu L,2 Takenaka N, Sakaguchi M, Kataoka T, Nishigori C.
Phospholipase Cepsilon plays a crucial role in ultraviolet B-induced neutrophil-associated skin inflammation by regulating the expression of CXCL1/KC
Cardinogenesis, 31(10):1897-902

Kobayashi T, Ishida J, Musashi M, Ota S, Yoshida T, Shimizu Y, Chuma M, Kawakami H, Asaka M, Tanaka J, Imamura M, Kobayashi M, Itoh H, Edamatsu H, Sutherland LC, Brachmann RK.
p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5.(2011)
Int J Cancer, 128(2):304-318.

 
2010年

Oka M, Edamatsu H, Kunisada M, Hu L, Takenaka N, Dien S, Kitazawa R, Norose K, Kataoka T, Nishigori C.
Enhancement of ultraviolet B-induced skin tumor development in
phospholipase Cepsilon knockout mice is associated with decreased cell death..(2010)
Carcinogenesis, 31(10):1897-1902

Shima F, Ijiri Y, Muraoka S, Liao J, Ye M, Araki M, Matsumoto K, Yamamoto N, Sugimoto T, Yoshikawa Y, Kumasaka T, Yamamoto M, Tamura A, Kataoka T.
Structural basis for conformational dynamics of GTP-bound Ras protein.(2010)
J Biol Chem. 285(29):22696-705

Kobayashi T, Ishida J, Musashi M, Ota S, Yoshida T, Shimizu Y, Chuma M, Kawakami H,
Asaka M, Tanaka J, Imamura M, Kobayashi M, Itoh H, Edamatsu H,
Sutherland LC, Brachmann RK.
p53 transactivation is involved in the antiproliferative activity of the
putative tumor suppressor RBM5.(2010)
Int J Cancer, In press

Ueda S, Kitazawa S, Ishida K, Nishikawa Y, Matsui M, Matsumoto H, Aoki T, Nozaki S,
Takeda T, Tamori Y, Aiba A, Kahn CR, Kataoka T, Satoh T (2010)
Crucial role of the small GTPase Rac1 in insulin-stimulated translocation of
glucose transporter 4 to the mouse skeletal muscle sarcolemma.
FASEB J. 24(7):2254-61

Hu L, Edamatsu H, Takenaka N, Ikuta S, Kataoka T. (2010)
Crucial role of phospholipase C{epsilon} in induction of local skin
inflammatory reactions in the elicitation stage of allergic contact
hypersensitivity.
J. Immunol. 184(2):993-1002

 
2009年

Kobayashi T, Hori Y, Ueda N, Kajiho H, Muraoka S, Shima F, Kataoka T, & Katada T (2009)
Biochemical characterization of missense mutations in the Arf/Arl-family small GTPase Arl6 causing Bardet-Biedl syndrome.
Biochem. Biophys. Res. Comm. 381(3):439-442

Ono R, Kumagai H, Nakajima H, Hishiya A, Taki T, Horikawa K, Takatsu K, Satoh T, Hayashi Y
Kitamura T, and Nosaka T (2009)
Mixed-lineage-leukemia (MLL) fusion protein collaborates with Ras to induce acute
leukemia through aberrant Hox expression and Raf activation.
Leukemia. 23(12):2197-209

Kanemura H, Satoh T, Bilasy SE, Ueda S, Hirashima M, and Kataoka T (2009)
Impaired vascular development in the yolk sac and allantois in mice lacking
RA-GEF-1.
Biochem. Biophys. Res. Commun. 387(4):754-759

Aoki T, Ueda S, Kataoka T, and Satoh T (2009)
Regulation of mitotic spindle formation by the RhoA guanine nucleotide exchange factor ARHGEF10.
BMC Cell Biol. 10: 56

Li M, Edamatsu H, Kitazawa R, Kitazawa S, Kataoka T. (2009)
Phospholipase C{epsilon} promotes intestinal tumorigenesis of ApcMin/+ mice through augmentation of inflammation and angiogenesis.

Carcinogenesis. 30(8):1424-1432

Bilasy SE, Satoh T, Ueda S, Wei P, Kanemura H, Aiba A, Terashima T,
and Kataoka T. (2009)
Dorsal telencephalon-specific RA-GEF-1 knockout mice develop heterotopic cortical mass and commissural fiber defect.
Eur. J. Neurosci. 29(10):1994-2008

2008年
Ueda S, Kataoka T, and Satoh T. (2008)
Activation of the small GTPase Rac1 by a specific
guanine-nucleotide-exchange factor suffices to induce glucose uptake into
skeletal-muscle cells.
Biol. Cell. 100 (11): 645-657

Liao J, Shima F, Araki M, Ye M, Muraoka S, Sugimoto T, Kawamura M, Yamamoto N,
Tamura A, and Kataoka T. (2008)
Two conformational states of Ras GTPase exhibit differential GTP-binding kinetics
Biochem Biophys Res Commun. 369(2):327-332

Ikuta S, Edamatsu H, Li M, Hu L, Kataoka T. (2008)
Crucial role of phospholipase C epsilon in skin inflammation induced by tumor-promoting phorbol ester.
Cancer Res. 68: 64-72. 

Suh PG, Park JI, Manzoli L, Cocco L, Peak JC, Katan M, Fukami K, Kataoka T,
Yun S, Ryu SH. (2008)
Multiple roles of phosphoinositide-specific phospholipase C isozymes.
BMB Rep. 2008 Jun 30;41(6):415-434.
 
2007年
Wei P, Satoh T, Edamatsu H, Aiba A, Setsu T, Terashima T, Kitazawa S, Nakao K,
Yoshikawa Y, Tamada M, Kataoka T. (2007)
Defective vascular morphogenesis and mid-gestation embryonic death in mice lacking
RA-GEF-1.
Biochem Biophys Res Commun. 363: 106-112.

Yoshikawa Y, Satoh T, Tamura T, Wei P, Bilasy SE, Edamatsu H, Aiba A, Katagiri K,
Kinashi T, Nakao K, Kataoka T. (2007)
The M-Ras-RA-GEF-2-Rap1 pathway mediates tumor necrosis factor-alpha dependent regulation of integrin activation in splenocytes.
Mol Biol Cell. 18: 2949-2959.

Ieguchi K, Ueda S, Kataoka T, and Satoh T. (2007)
Role of the guanine nucleotide exchange factor Ost in negative regulation of receptor
endocytosis by the small GTPase Rac1.
J. Biol. Chem. 282 (32): 23296-23305

Shibasaki T, Takahashi H, Miki T, Sunaga Y, Matsumura K, Yamanaka M,
Zhang C, Tamamoto A, Satoh T, Miyazaki J, Seino S.(2007)
Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP.
Proc. Natl. Acad. Sci.USA 104 (49), 19333-19338

Satoh, T. (2007)
The signaling network of Ras family and Rho family
GTP-binding proteins in mammalian cells.
"Cellular Signaling and Apoptosis Research" (Alex R. Demasi, ed; Nova
Science Publishers, Hauppauge, NY, USA) 221-246
 
2006年 
Edamatsu H, Satoh T, Kataoka T. (2006)
Ras and Rap1 activation of PLCepsilon lipase activity.
Methods Enzymol. 407:99-107.

Satoh T, Edamatsu H, Kataoka T. (2006)
Phospholipase Cepsilon guanine nucleotide exchange factor activity and activation of Rap1.
Methods Enzymol. 407:281-190.
 
2005年 
Ye M, Shima F, Muraoka S, Liao J, Okamoto H, Yamamoto M, Tamura A, Yagi N, Ueki T,
Kataoka T. (2005)
Crystal structure of M-Ras reveals a GTP-bound "off" state conformation of Ras family
small GTPases.

J Biol Chem.
280(35):31267-31275.


Tadano M, Edamatsu H, Minamisawa S, Yokoyama U, Ishikawa Y, Suzuki N, Saito H, Wu D, Masago-Toda M,
Yamawaki-Kataoka Y, Setsu T, Terashima T, Maeda S, Satoh T, Kataoka T. (2005)

Congenital semilunar valvulogenesis defect in mice deficient in phospholipase C epsilon.
Mol Cell Biol. 25(6):2191-2199.

Nur-E-Kamal A, Zhang A, Keenan SM, Wang XI, Seraj J, Satoh T, Meiners S, Welsh WJ.
(2005)

Requirement of activated Cdc42-associated kinase for survival of v-Ras-transformed mammalian cells.
Mol Cancer Res. 3(5):297-305.
 
2004年

Ogihara H, Shima F, Naito K, Asato T, Kariya K, Kataoka T. (2004)
Direct Activation of Fission Yeast Adenylyl Cyclase by Heterotrimeric G Protein gpa2.

Kobe J Med Sci. 50(4):111-121.

Bai Y, Edamatsu H, Maeda S, Saito H, Suzuki N, Satoh T, Kataoka T. (2004)
Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development.
Cancer Res. 64(24):8808-8810.

Kariya K, Kim Bui Y, Gao X, Sternberg PW, Kataoka T. (2004)
Phospholipase Cepsilon regulates ovulation in Caenorhabditis elegans.
Dev Biol. 274(1):201-210.

Ueda S, Kataoka T, Satoh T. (2004)
Role of the Sec14-like domain of Dbl family exchange factors in the regulation of
Rho family GTPases in different subcellular sites.
Cell Signal. 16(8):899-906.

Nomura K, Kanemura H, Satoh T, Kataoka T. (2004)
Identification of a novel domain of Ras and Rap1 that directs their differential subcellular localizations.

J Biol Chem. 279(21):22664-22673.

 
2003年
Honma N, Asada A, Takeshita S, Enomoto M, Yamakawa E, Tsutsumi K, Saito T, Satoh T,
Itoh H, Kaziro Y, Kishimoto T, Hisanaga S. (2003)

Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein.
Biochem Biophys Res Commun. 310(2):398-404.

Hibino K, Watanabe TM, Kozuka J, Iwane AH, Okada T, Kataoka T, Yanagida T, Sako Y.
(2003)

Single- and multiple-molecule dynamics of the signaling from H-Ras to cRaf-1 visualized
on the plasma membrane of living cells.

Chemphyschem. 4(7):748-753.

Minoshima Y, Kawashima T, Hirose K, Tonozuka Y, Kawajiri A, Bao YC, Deng X, Tatsuka M, Narumiya S, May
WS Jr, Nosaka T, Semba K, Inoue T, Satoh T, Inagaki M, Kitamura T. (2003)

Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis.
Dev Cell. 4(4):549-560.

Wu D, Tadano M, Edamatsu H, Masago-Toda M, Yamawaki-Kataoka Y, Terashima T,
Mizoguchi A, Minami Y, Satoh T, Kataoka T. (2003)

Neuronal lineage-specific induction of phospholipase Cepsilon expression in the developing mouse brain.
Eur J Neurosci. 17(8):1571-1580.

Mitsuhashi S, Shima H, Tanuma N, Matsuura N, Takekawa M, Urano T, Kataoka T, Ubukata M, Kikuchi K.
(2003)

Usage of tautomycetin, a novel inhibitor of protein phosphatase 1 (PP1), reveals
that PP1 is a positive regulator of Raf-1 in vivo.

J Biol Chem. 278(1):82-88.
 
2002年
Edamatsu H, Kaziro Y, Itoh H. (2002)
Differential display of mRNAs regulated by G-protein signaling.
Methods Enzymol. 345:521-529.

Song C, Satoh T, Edamatsu H, Wu D, Tadano M, Gao X, Kataoka T. (2002)

Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase
C epsilon.

Oncogene. 21(53):8105-8113.

Kato-Stankiewicz J, Hakimi I, Zhi G, Zhang J, Serebriiskii I, Guo L, Edamatsu H, Koide H,
Menon S, Eckl R, Sakamuri S, Lu Y, Chen QZ, Agarwal S, Baumbach WR, Golemis EA,
Tamanoi F, Khazak V. (2002)

Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells.
Proc Natl Acad Sci U S A. 99(22):14398-14403.

Tanaka Y, Nakayamada S, Fujimoto H, Okada Y, Umehara H, Kataoka T, Minami Y. (2002)
H-Ras/mitogen-activated protein kinase pathway inhibits integrin-mediated adhesion and induces apoptosis in osteoblasts.
J Biol Chem. 277(24):21446-21452.

Kido M, Shima F, Satoh T, Asato T, Kariya K, Kataoka T. (2002)
Critical function of the Ras-associating domain as a primary Ras-binding site for regulation
of Saccharomyces cerevisiae adenylyl cyclase.

J Biol Chem. 277(5):3117-3123.
 
2001年
Gao X, Satoh T, Liao Y, Song C, Hu CD, Kariya Ki K, Kataoka T. (2001)
Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a
downstream target of M-Ras.

J Biol Chem. 276(45):42219-42225.

Tamanoi F, Gau CL, Jiang C, Edamatsu H, Kato-Stankiewicz J. (2001)
Protein farnesylation in mammalian cells: effects of farnesyltransferase inhibitors on cancer
cells.

Cell Mol Life Sci. 58(11):1636-1649.

Jin TG, Satoh T, Liao Y, Song C, Gao X, Kariya K, Hu CD, Kataoka T. (2001)
Role of the CDC25 homology domain of phospholipase Cepsilon in amplification of
Rap1-dependent signaling.

J Biol Chem. 276(32):30301-30307.

Liao Y, Satoh T, Gao X, Jin TG, Hu CD, Kataoka T. (2001)
RA-GEF-1, a guanine nucleotide exchange factor for Rap1, is activated by translocation
induced by association with Rap1*GTP and enhances Rap1-dependent B-Raf activation.

J Biol Chem. 276(30):28478-28483.

Pervin S, Singh R, Gau CL, Edamatsu H, Tamanoi F, Chaudhuri G. (2001)
Potentiation of nitric oxide-induced apoptosis of MDA-MB-468 cells by farnesyltransferase
inhibitor: implications in breast cancer.

Cancer Res. 61(12):4701-4706.

Kato-Stankiewicz J, Ueda S, Kataoka T, Kaziro Y, Satoh T. (2001)
Epidermal growth factor stimulation of the ACK1/Dbl pathway in a Cdc42 and
Grb2-dependent manner.

Biochem Biophys Res Commun. 284(2):470-477.

Oishi I, Iwai K, Kagohashi Y, Fujimoto H, Kariya K, Kataoka T, Sawa H, Okano H, Otani H,
Yamamura H, Minami Y. (2001)

Critical role of Caenorhabditis elegans homologs of Cds1 (Chk2)-related kinases in meiotic recombination.
Mol Cell Biol. 21(4):1329-1335.

Song C, Hu CD, Masago M, Kariyai K, Yamawaki-Kataoka Y, Shibatohge M, Wu D, Satoh T, Kataoka T. (2001)
Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting
by Ras.

J Biol Chem. 276(4):2752-2757.
 
2000年
Kiyono M, Kato J, Kataoka T, Kaziro Y, Satoh T. (2000)
Stimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon
tyrosine phosphorylation by the Cdc42-regulated kinase ACK1.

J Biol Chem. 275(38):29788-29793.

Sendoh H, Hu CD, Wu D, Song C, Yamawaki-Kataoka Y, Kotani J, Okada T, Shima F,
Kariya K, Kataoka T. (2000)

Role of Raf-1 conserved region 2 in regulation of Ras-dependent Raf-1 activation.
Biochem Biophys Res Commun. 271(3):596-602.

Shima F, Okada T, Kido M, Sen H, Tanaka Y, Tamada M, Hu CD, Yamawaki-Kataoka Y,
Kariya K, Kataoka T. (2000)

Association of yeast adenylyl cyclase with cyclase-associated protein CAP forms a second Ras-binding site which mediates its Ras-dependent activation.
Mol Cell Biol. 20(1):26-33.
 
1999年

Okada T, Hu C-D, Jin, T-G, Kariya K., Yamawaki-Kataoka Y, & Kataoka T. (1999)
The strength of Interaction at Raf cysteine-rich domain is a critical determinant of
response of Raf to Ras family small GTPases.
Mol. Cell. Biol. 19: 6057-6064.

Hu C-D, Kariya K, Okada T, Qi, X., Song, C, & Kataoka T. (1999)
Effect of phosphorylation on activities of Rap1A to interact with Raf-1 and to suppress
Ras-dependent Raf-1.
J. Biol. Chem. 274:48-51.

Liao Y, Kariya K, Hu C-D, Shibatohge M, Goshima M, Okada T, Watari Y, Gao X, Jin T-G, Yamawaki-Kataoka Y, Kataoka T. (1999)
RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humans.
J. Biol. Chem. 274:37815-37820.

Tanaka Y, Minami Y, Mine S, Hirano H, Hu C-D, Fujimoto H, Saito K, Tsukada J, van Kooyk Y, Figdor C.G. Kataoka T, Eto S. (1999)
H-Ras signals to cytoskeletal machinery in induction of integrin-mediated adhesion of T
cells.
J. Immunol. 163: 6209-6216.

Goshima M, Kariya K, Yamawaki-Kataoka Y, Okada T, Shibatohge M, Shima F, Fujimoto E, Kataoka T. (1999)
Characterization of a novel Ras-binding protein Ce-FLI-1 comprising leucine-rich repeats
and gelsolin-like domains.
Biochem. Biophys. Res. Comm. 257: 111-116.

 
1998年

Onishi M, Yamawaki-Kataoka Y, Kariya K, Tamada M, Hu C-D, & Kataoka T. (1998)
Selective inhibition of Ras interaction with its particular effector by synthetic peptides corresponding to the Ras effector region.
J. Biol. Chem. 273:10210-10215.

Shirouzu M, Morinaka K, koyama S, Hu C-D, Hori-Tamura N, Okada T, Kariya K,
Kataoka T, Kikuchi A, & Yokoyama S. (1998)
Interaction of the amino acid residue at position 31 of the c-Ha-Ras protein with Raf-1
and RalGDS.
J. Biol. Chem. 273:7737-7742.

Kim J. H, Shirouzu M, Kataoka T, Bowtell D, and Yokoyama S. (1998)
Activation of Ras and its downstream extracellular signal-regulated protein kinases by the CDC25 homology domain of mouse Son-of-sevenless 1 (mSos1).
Oncogene 16:2597-2607.

Nishida Y, Shima, F, Sen H, Tanaka Y, Yanagihara C, Yamawaki-Kataoka, Y, Kariya K,
& Kataoka T. (1998)
Coiled-coil interaction of N-terminal 36 residues of cyclase-associated protein with
adenylyl cyclase is sufficient for ots function in Saccharomyces cerevisiae Ras pathway.
J. Biol. Chem. 273:28019-28024.

Shibatouge M, Kariya K, Liao Y, Hu C-D, Watari Y, Goshima M, Shima F, & Kataoka T. (1998)
Identification of PLC210, a Caenorhabditis elegans phospholipase C, as a putative effector
of Ras.
J. Biol. Chem. 273:6218-6222.

Watari Y, Kariya K, Shibatouge M, Liao Y, Hu C-D, Goshima M, Tamada M, Kikuchi A,
& Kataoka T. (1998)
Identification of Ce-AE-6, a novel Caenorhabditis elegans protein, as a Ras putative effector. Gene 224:53-58.

 
1997年

Tamada, M., Hu, C-D., Kariya, K., Okada, T., Kataoka, T. (1997)
Membarne recruitment of Raf-1 is not the only function of Ras in Raf-1 activation.
Oncogene 15, 2959-2964.

Hu C-D, Kariya K, Kotani G, Shirouzu M, Yokoyama S & Kataoka T. (1997)
Coassociation of Rap1A and Ha-Ras with Raf-1 N-terminal region interferes with Ras-dependent activation of Raf-1.
J. Biol. Chem. 272:11702-11705.

Shima F, Yamawaki-Kataoka Y, Yanagihara C, Tamada M, Okada T, Kariya K & Katao T. (1997)
Effect of association with adenylyl cyclase-associated protein on the interaction of yeast adenylyl cyclase with Ras protein.
Mol. Cell. Biol. 17:1057-1064.

Okazaki M, Kishida S, Hinoi T, Hasegawa T, Tamada M, Kataoka T & Kikuchi A. (1997)
Synergistic activation of c-fos promoter activity by Raf and Ral GDP dissociation stimulator.
Oncogene 14:515-521.

Yanagihara C, Shinkai M, Kariya K, Yamawaki-Kataoka Y, Hu C-D, Masuda T & Kataoka T.
(1997)
Association of elongation factor 1a and ribosomal protein L3 with the proline-rich region of yeast adenylyl cyclase-associated protein CAP.
Biochem. Biophys. Res. Comm. 232:503-507.

Hu C-D, Kariya K, Kotani G., Shirouzu M, Yokoyama S. & Kataoka T. (1997)
Coassociation of Rap1A and Ha-Ras with Raf-1 N-terminal region interferes with Ras-dependent activation of Raf-1.
J. Biol. Chem. 272:11702-11705.

Kariya K, Shibatouge M, Watari Y, Goshima, M., Barstead, R. & Kataoka, T. (1997)
C. elegans homologs of ralGDS, AF-6, Cdc25 and phospholipase C interact with Let-60.
Worm Breeder's Gazette 14(5):34-35.

 
1996年

Okada T, Masuda T, Shinkai M, Kariya K & Kataoka T. (1996)
Post-translational modification of H-Ras is required for activation of, but not for association with, B-Raf.
J. Biol. Chem. 271:4671-4678.

Shinkai M, Masuda T, Kariya K, Tamada M, Shirouzu M, Yokoyama S & Kataoka T. (1996)
Difference in the mechanism of interaction of Raf-1 and B-Raf with H-Ras.
Biochem. Biophys. Res. Comm. 223:729-734.

Akasaka K, Tamada M, Wang F, Kariya K, Shima F, Kikuchi A, Yamamoto M, Shirouzu M, Yokoyama S & Kataoka T. (1996)
Differential structural requirements for interaction of Ras protein with its distinct downstream effectors.
J. Biol. Chem. 271:5353-5360.

Shinkai M, Masuda T, Kariya K, Tamada M, Shirouzu M, Yokoyama S & Kataoka T. (1996)
Difference in the mechanism of interaction of Raf-1 and B-Raf with H-Ras.
Biochem. Biophys. Res. Comm. 223:729-734.

Okada T, Masuda T, Shinkai M, Kariya K & Kataoka T. (1996)
Post-translational modification of H-Ras is required for activation of, but not for association with, B-Raf.
J. Biol. Chem. 271:4671-4678.

 
1995年

Hu C-D, Kariya K, Tamada M, Akasaka K, Shirouzu, M., Yokoyama, S. & Kataoka, T. (1995)
Cysteine-rich region of Raf-1 interacts with activator domain of post-translationally
modified H-Ras.
J. Biol. Chem. 270:30274-30277.

Hu C-D, Kariya K, Tamada M, Akasaka K, Shirouzu M, Yokoyama S & Kataoka T. (1995)
Cysteine-rich region of Raf-1 interacts with activator domain of post-translationally
modified H-Ras.
J. Biol. Chem. 270:30274-30277.

Kariya K, Yamawaki-Kataoka Y, Shibatohge M, Okada T, Shima F, Watari Y, Goshima M,
Akasaka K, Suzuki N & Kataoka T. (1995)
The novel Ras-binding protein Ach-1 is associated with centrosomes.
Worm Breeder's Gazette 14:78-79.

Masuda T, Kariya K, Shinkai M, Okada T & Kataoka T. (1995)
Protein kinase Byr2 is a target of Ras1 in fission yeast Schizosaccharomyces pombe.
J. Biol. Chem. 270:1979-1982.

 
1994年
Minato T, Wang J, Akasaka K, Okada T, Suzuki N & Kataoka T. (1994)
Quantitative analysis of the mutually competitive binding of human Raf-1 and yeast adenylyl cyclase to Ras proteins.
J. Biol. Chem. 269:20845-20851.

1993年

Kuroda Y, Suzuki N & Kataoka T. (1993)
The effect of posttranslational modifications on the interaction of Ras2 with adenylyl
cyclase.
Science 259:683-686.

Suzuki N, Tsujino K, Minato T, Nishida Y, Okada T & Kataoka T. (1993)
Antibody mimicking the action of RAS proteins on yeast adenylyl cyclase:Implication for
RAS-effector interaction.
Mol. Cell. Biol. 13:769-774.

Wang J, Suzuki N, Nishida Y & Kataoka T. (1993)
Analysis of the function of 70-kilodalton cyclase-associated protein (CAP) by using mutants
of yeast adenylyl cyclase defective in CAP binding.
Mol. Cell. Biol. 13:4087-4097.

 
1992年

Wang J, Suzuki N & Kataoka T. (1992)
The 70kDa CAP(adenylyl cyclase-associated protein) is not essential for interaction of Saccharomyces cerevisiae adenylyl cyclase with RAS proteins.
Mol. Cell. Biol. 12:4937-4945.

Horiuchi H, Kaibuchi K, Kawamura M, Matsuura Y, Suzuki N, Kuroda Y, Kataoka T & Takai Y. (1992)
The posttranslational processing of ras p21 is critical for its stimulation of yeast adenylate cyclase.
Mol. Cell. Biol. 12:4515-4520.

 
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