Division of Microbiology


Publications


2014


1. El-Shamy A, Hotta H. Impact of hepatitis C virus heterogeneity on interferon sensitivity: An overview. World J Gastroenterol. 20(24): 7555-7569, 2014.

2. Utsumi T, Yano Y, Hotta H. Molecular epidemiology of hepatitis B virus in Asia.World J Med Genet, 4: 19-26, 2014.

3. Takei S, Omoto C, Kitagawa K, Morishita N, Katayama T, Shigemura K, Fujisawa M, Kawabata M, Hotta H, Shirakawa T. Oral administration of genetically modified Bifidobacterium displaying HCV-NS3 multi-epitope fusion protein could induce an HCV-NS3-specific systemic immune response in mice. Vaccine, 32(25): 3066-3074, 2014.

4. Ratnoglik SL, Jiang DP, Aoki C, Sudarmono P, Shoji I, Deng L, Hotta H. Induction of cell-mediated immune responses in mice by DNA vaccines that express hepatitis C virus NS3 mutants lacking serine protease and NTPase/RNA helicase activities. PLoS One, 9(6): e98877, 2014.

5. Aoki C, Hartati S, Santi MR, Lydwina, Firdaus R, Hanafi M, Kardono LB, Shimizu Y, Sudarmono P, Hotta H. Isolation and identification of substances with anti-hepatitis C virus activities from Kalanchoe pinnata. Int J Pharm Pharmaceut Sci, (in press)

6. Adianti M, Aoki C, Komoto M, Deng L, Shoji I, Wahyuni TS, Lusida MI, Soetjipo, Fuchino H, Kawahara N, Hotta H. Anti-hepatitis C virus compounds obtained from Glycyrrhiza uralensis and other Glycyrrhiza species. Microbiol Immunol, 58(3): 180-187, 2014.

7. Ratnoglik SL, Aoki C, Sudarmono P, Komoto M, Deng L, Shoji I, Fuchino H, Kawahara N, Hotta H. Antiviral activity of extracts from Morinda citrifolia leaves and chlorophyll catabolites pheophorbide a and pyropheophorbide a, against hepatitis C. Microbiol Immunol, 58(3): 188-194, 2014.

8. Juniastuti, Wibowo BP, Wibawa IDN, Utsumi T, Mustika S, Amin M, Wahyuni RM, Kurniawan H, Hendrayana A, Setiawan PB, Yamani LN, Soetjipto, Yano Y, Hotta H, Hayashi Y, Lusida MI. Analysis of interleukin-28B polymorphisms and pegylated-1 interferon/ribavirin response of Indonesian chronic hepatitis C. J Clin Microbiol, 52(6): 2193-2195, 2014.

9. Juniastuti, Utsumi T, Nasronudin, Alimsardjono L, Amin M, Adianti M, Yano Y, Soetjipto, Hayashi Y, Hotta H, Lusida MI. High rate of seronegative HCV infection in HIV-positive patients. Biomed Rep. 2(1): 79-84, 2014.

10. Bai F, Yano Y, Kim SR, Seo Y, Miki A, Saito M, Hirano H, Momose K, Minami A, Hatazawa Y, Hayakumo T, Widasari DI, Rinonce HT, Sugano M, Tani S, Yoon S, Imoto S, Azuma T,Hotta H, Hayashi Y. Mutational diversity of NS5A and NS3 during triple therapy (telaprevir, pegylated-interferon-α 2b and ribavirin) for genotype 1b chronic hepatitis C: The Kobe Hepatitis Therapeutic Group. Int J Mol Med, 33(6): 1652-1656, 2014.

11. Tao RR, Huang JY, Lu YM, Hong LJ, Wang H, Masood MA, Ye WF, Zhu DY, Huang Q, Fukunaga K, Lou YJ, Shoji I, Wilcox CS, Lai EY, Han F. Nitrosative stress induces peroxiredoxin 1 ubiquitination during ischemic insult via E6AP activation in endothelial cells both in vitro and in vivo. Antioxidants & Redox Signaling, 21(1): 1-16, 2014.

12. 堀田博, ワクチン開発の現状, Med Sci Digest, (in press)

13. 内海孝子, 林祥剛, 堀田博 【感染症研究国際ネットワーク研究の現状】 インドネシア共和国拠点神戸大学-インドネシア 新興・再興感染症国際共同研究拠点. 化学療法の領域 30(6): 97-108, 2014.



2013

1. El-Shamy A, Shindo M, Shoji I, Deng L, Okuno T, Hotta H. Polymorphisms of the core, NS3 and NS5A proteins of hepatitis C virus genotype 1b associate with development of hepatocellular carcinoma. Hepatology, 58(2): 555-563, 2013.

2. Shimizu YK, Hijikata M, Oshima M, Shimizu K, Alter HJ, Purcell RH, Yoshikura H, Hotta H. Isolation of human monoclonal antibodies to the envelope E2 protein of hepatitis C virus and their characterization. PLoS ONE, 8(2): e55874, 2013.

3. Utsumi T, Yano Y, Lusida MI, Nasronudin, Amin M, Juniastuti, Soetjipto, Hotta H, Hayashi Y. Detection of highly prevalent hepatitis B virus co-infection with HIV in Indonesia. Hepatol Res, 43: 1032-1039, 2013.

4. Mawatari S, Uto H, Ido A, Nakashima K, Suzuki T, Kanmura S, Kumagai K, Oda K, Tabu K, Tamai T, Moriuchi A, Oketani M, Shimada Y, Sudoh M, Shoji I, Tsubouchi H. Hepatitis C virus NS3/4A protease inhibits complement activation by cleaving complement component 4. PLoS One, 2013, 8 (12): e82094.

5. Ichimura T, Taoka M, Shoji I, Kato H, Hatakeyama S, Isobe T, Hachiya N. 14-3-3 Proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitylation and cytoplasmic body formation. J Cell Sci, 1;126: 2014-2026, 2013.

6. Rinonce HT, Yano Y, Utsumi T, Heriyanto DS, Anggorowati N, Widasari DI, Lusida MI, Soetjipto, Prasanto H, Hotta H, Hayashi Y. Hepatitis B and C virus infection among hemodialysis patients in yogyakarta, Indonesia: Prevalence and molecular evidence for nosocomial transmission. J Med Virol, 5(8): 1348-1361, 2013.

7. Widasari DI, Yano Y, Utsumi T, Heriyanto DS, Anggorowati N, Rinonce HT, Utoro T, Lusida MI, Soetjipto, Asmara W, Hotta H, Hayashi Y. Hepatitis E virus infection in two different community settings with identification of swine HEV genotype 3 in Indonesia. Microbiol Immunol, 57: 692-703, 2013.

8. Juniastuti, Utsumi T, Aksono EB, Yano Y, Soetjipto, Hayashi Y, Hotta H, Rantam FA, Kusumobroto HO, Lusida MI. Predominance of precore mutations and clinical significance of basal core promoter mutations in chronic hepatitis B virus infection in Indonesia. Biomed Rep, 1(4): 522-528, 2013.

9. Wahyuni TS, Tumewu L, Permanasari AA, Apriani E, Adianti M, Rahman A, Widyawaruyanti A, Lusida MI, Fuad A, Soetjipto, Nasronudin, Fuchino H, Kawahara N, Shoji I, Deng L, Aoki C, Hotta H. Antiviral activities of Indonesian medicinal plants in the East Java region against hepatitis C virus. Virol J, 10: 259 (13 August 2013).

10. Sugimoto K, Kim SR, El-Shamy A, Imoto S, Ando K, Kim KI, Tanaka Y, Yano Y, Kim SK, Hasegawa Y, Fujinami A, Ohta M, Takashi H, Hotta H, Hayashi Y, Kudo M. Factors of response to pegylated interferon/ribavirin combination therapy and mechanism of viral clearance. Dig Dis, 31(5-6): 421-425, 2013.

11. Kim SR, El-Shamy A, Imoto S, Kim KI, Sugimoto K, Kim SK, Tanaka Y, Hatae T, Hasegawa Y, Fujinami A, Ohta M, Hotta H, Kudo M. Prediction of response to pegylated interferon/ribavirin combination therapy for chronic hepatitis C genotypes 2a and 2b and high viral load. Dig Dis, 31(5-6): 426-433, 2013.

12. Sugimoto K, Kim SR, El-Shamy A, Imoto S, Fujioka H, Kim KI, Tanaka Y, Yano Y, Kim SK, Hasegawa Y, Fujinami A, Ohta M, Hatae T, Hotta H, Hayashi Y, Kudo M. Outcome of double-filtration plasmapheresis plus interferon treatment in nonresponders to pegylated interferon plus ribavirin combination therapy. Dig Dis, 31(5-6): 434-439, 2013.

13. 内海孝子, 林祥剛, 堀田博 【海外拠点におけるウイルス感染症研究】神戸大学インドネシア拠点における国際共同研究活動 解説特集 ウイルス 63巻 1号 Page59-67(2013.06)



2012

1. Matsui C, Shoji I, Kaneda S, Sianipar IR, Deng L, Hotta H. Hepatitis C virus infection suppresses GLUT2 gene expression via down-regulation of hepatocyte nuclear factor 1α. J Virol, 86(23): 12903-12911, 2012.

2. Shoji I, Deng L, Hotta H. Molecular mechanism of hepatitis C virus-induced glucose metabolic disorders. Front Microbiol, 2: A278, 1-5. 2012.

3. El-Shamy A, Shoji, Kim SR, Ide Y, Imoto S, Deng L, Yoon S, Fujisawa T, Tani S, Yano Y, Seo Y, Azuma T, Hotta H. Sequence heterogeneity in NS5A of hepatitis C virus genotypes 2a and 2b and clinical outcome of pegylated-interferon/ribavirin therapy. PLoS ONE, 7(2): e30513. 2012.

4. El-Shamy A, Shoji I, El-Akel W, Bilasy SE, Deng L, El-Raziky M, Jiang DP, Esmat G, Hotta H. NS5A sequence heterogeneity of hepatitis C virus genotype 4a predicts clinical outcome of pegylated-interferon/ribavirin therapy in Egyptian patients. J Clin Microbiol,50(12): 3886-3892, 2012.

5. Nakashima K, Takeuchi K, Chihara K, Horiguchi T, Sun X, Deng L, Shoji I, Hotta H, Sada K. HCV NS5A protein containing potential ligands for both Src homology 2 and 3 domains enhances autophosphorylation of Src family kinase Fyn in B cells. PLoS ONE, 7(10): e46634, 2012.

6. Kamada K, Shoji I, Deng L, Aoki C, Ratnoglik SL, Wakita T, Hotta H. Generation of a recombinant reporter hepatitis C virus useful for the analyses of virus entry, intra-cellular replication and virion production. Microbes Infect, 14(1): 69-78, 2012.

7. Sasayama M, Shoji I, Adianti M, Jiang D-P, Deng L, Saito T, Watanabe H, Kawata S, Aoki C, Hotta H. A point mutation at ASN-534 that disrupts a conserved N-glycosylation motif of the E2 glycoprotein of hepatitis C virus markedly enhances the sensitivity to antibody neutralization. J Med Virol, 84(2): 229-234, 2012.

8. El-Shamy A, Kim SR, Ide Y-H, Sasase N, Imoto S, Deng L, Shoji I, Hotta H. Polymorphisms of hepatitis C virus NS5A and core proteins and clinical outcome of pegylated interferon/ribavirin combination therapy. Intervirology, 55(1): 1-11, 2012.

9. Shoji I. Roles of the two distinct proteasome pathways in hepatitis C virus infection. World J Virol, 1(2): 44-50, 2012.

10. Kim SR, El-Shamy A, Imoto S, Kim KI, Ide YH, Deng L, Shoji I, Tanaka Y, Hasegawa Y, Ota M, Hotta H. Prediction of response to pegylated interferon/ribavirin combination therapy for chronic hepatitis C genotype 1b and high viral load. J Gastroenterol, 47(10): 1143-1151, 2012.

11. Yano Y, Seo Y, Miki A, Saito M, Kato H, Hamano K, Oya M, Ouchi S, Fujisawa T, Yamada H, Yamashita Y, Tani S, Hirohata S, Yoon S, Kitajima N, Kitagaki K, Kawara A, Nakashima T, Yu H, Maeda T, Azuma T, El-Shamy A, Hayashi Y. Mutations in non-structural 5A and rapid viral response to pegylated interferon-α-2b plus ribavirin therapy are associated with therapeutic efficacy in patients with genotype 1b chronic hepatitis C. Int J Mol Med, 30(5): 1048-1052, 2012.

12. 進藤道子、 El-Shamy Ahmed、奥野忠雄、堀田博. C型慢性肝炎時から肝癌発生まで経過を追えたC型肝炎ウイルスジェノタイプ1bのコア蛋白アミノ酸多様性と肝癌発生との関連性 肝臓 53(9), 541-548, 2012.

13. 勝二郁夫、堀田博. NS5A-IRRDR変異数. 最新! C型肝炎治療薬の使いかた. 岡上武監修, 83-87, 2012.


2011

1. Deng L, Shoji I, Ogawa W, Kaneda S, Soga T, Jiang DP, Ide YH, Hotta H. Hepatitis C virus infection promotes hepatic gluconeogenesis through an NS5A-mediated, FoxO1-dependent pathway. J Virol, 85(17): 8556-8568, 2011.

2. El-Shamy A, Shoji I, Saito T, Watanabe H, Ide YH, Deng L, Kawata S, Hotta H. Sequence heterogeneity of NS5A and core proteins of hepatitis C virus and virological responses to pegylated-interferon/ribavirin combination therapy. Microbiol Immunol, 55(6): 418-426, 2011.

3. Nakashima K, Takeuchi K, Chihara K, Hotta H, Sada K. Inhibition of hepatitis C virus replication through AMP-activated protein kinase-dependent and -independent pathways. Microbiol Immunol, 55(6): 418-426, 2011.

4. Yamagishi Y, Shoji I, Miyagawa S, Kawakami T, Katoh T, Goto Y, Suga H. Natural product-like macrocyclic N-methyl-peptide inhibitors against a ubiquitin ligase uncovered from a ribosome-expressed de novo library. Chemistry & Biology,18(12): 1562-1570, 2011.

5. Kim SR, Saito J, Imoto S, Komaki T, Nagata Y, Kim KI, Sasase N, Kimura N, Sasatani K, Konishi E, Hasegawa Y, Fujinami A, Ohta M, El-Shamy A, Tanaka Y, Sugano M, Sakashita M, Nakamura A, Tsuchida S, Makino T, Kawada T, Nakajima T, Morikawa T, Muramatsu A, Kasugai H, Hotta H, Kudo M. Double-filtration plasmapheresis plus interferon-β for HCV-1b patients with non-sustained virological response to previous combination therapy. Digestion, 84 Suppl 1: 10-16, 2011.

6.Kim SR, Saito J, Imoto S, Komaki T, Nagata Y, Nakajima T, Ando K, Fukuda K, Otono Y, Kim KI, Ohtani A, Sugimoto K, Hasegawa Y, Fujinami A, Ohta M, Hotta H, Maekawa Y, Hayashi Y, Kudo M. Correlation between insulin resistance and outcome of pegylated interferon and ribavirin therapy, hepatic steatosis, hepatic fibrosis in chronic hepatitis C-1b and high viral load. Digestion. 84 Suppl 1: 5-9, 2011.

7. Inoue Y, Aizaki H, Hara H, Matsuda M, Ando T, Shimoji T, Murakami K, Masaki T, Shoji I, Homma S, Matsuura Y, Miyamura T, Lai MMC, Wakita T, Suzuki T. Chaperonin TRiC/CCT participates in replication of hepatitis C virus genome via interaction with the viral NS5B protein. Virology, 410(1): 38-47, 2011.

8. Utsumi T, Hayashi Y, Lusida MI, Amin M, Soetjipto, Hendra A, Soetjiningsih, Yano Y, Hotta H. Prevalence of hepatitis E virus among swine and humans in two different ethnic communities in Indonesia. Arch Virol, 156(4): 689-693, 2011.

9. Wakita T, Suzuki T, Evans MJ, Shimotohno K, Chayama K, Matsuura Y, Hijikata M, Moriishi K, Seya T, Enomoto N, Koike K, Kato N, Kanto T, Hotta H. Will there be an HCV meeting in 2020? Summary of the 17th International Meeting on Hepatitis C Virus and Related Viruses. Gastroenterology, 141(1): e1-5, 2011.

10. Juniastuti, Utsumi T, Nugrahaputra VE, Amin M, Soetjipto, Hayashi Y, Hotta H, Lusida MI. Another novel subgenotype of hepatitis B virus genotype C from papuans of Highland origin. J Med Virol, 83(2): 225-234, 2011.

11. Hasegawa S, Mori N, Satomi M, Jiang DP, Hotta H, Matsushige T, Ichiyama T. Interferon production by cells infected with subacute sclerosing panencephalitis (SSPE) virus or measles virus. Cytokine, 56(3): 676-679, 2011.

12. Nishibori T, de Vries GC, Rahardjo D, Wasito EB, De I, Kinoshita S, Hayashi Y, Hotta H, Kawabata M, Shirakawa T, Iijima Y, Osawa R. Phenotypic and genotypic characterization of Vibrio cholerae clinically isolated in Surabaya, Indonesia. Jpn J Infect Dis, 64(1): 7-12, 2011.

13. 勝二郁夫, Ahmed El-Shamy, 堀田博. NS5A-IRRDR変異数. 医学のあゆみ. 239 (12-13 ), 1208-1211, 2011.

14. 勝二郁夫, Ahmed El-Shamy, 堀田博. C型肝炎ウイルスNS5A領域のISDR・IRRDRとインターフェロン治療効果予測. 肝胆膵. 56(3): 676-679. 2011.

15. 内海孝子、堀田博. HBVの構造と複製・増殖機構. 日本臨床, 69巻増刊4, 新時代のウイルス性肝炎学. 344-349, 2011.


2010


1. Hayashida K, Shoji I, Deng L, Jiang D-P, Ide Y-H, Hotta H. 17s-Estradiol inhibits the production of infectious particles of hepatitis C virus. Microbiol Immunol, 54(11): 684-690, 2010.

2. Utsumi T, Yano Y, Lusida MI, Amin M, Soetjipto, Hotta H, Hayashi Y. Serologic and molecular characteristics of hepatitis B virus among school children in East Java, Indonesia. Am J Trop Med Hyg, 83(1):189-193, 2010.

3. Nasu J, Murakami K, Miyagawa S, Yamashita R, Ichimura T, Wakita T, Hotta H, Miyamura T, Suzuki T, Satoh T, Shoji I. E6AP ubiquitin ligase mediates ubiquitin-dependent degradation of peroxiredoxin 1. J Cell Biochem, 111: 676-685, 2010.

4. Sasayama M, Deng L, Kim SR, Ide Y-H, Shoji I, Hotta H. Analysis of neutralizing antibodies against hepatitis C virus in patients who were treated with peglated-Interferon plus ribavirin. Kobe J Med Sci, 56(2): 60-66, 2010.

5. Sanjo M, Saito T, Ishii R, Nishise Y, Haga H, Okumoto K, Ito J, Watanabe H, Saito K, Togashi H, Fukuda K, Imai Y, El-Shamy A, Deng L, Shoji I, Hotta H, Kawata S. Secondary structure of the amino-terminal region of HCV NS3 and virological response to pegylated interferon plus ribavirin therapy for chronic hepatitis C. J Med Virol, 82(8): 1364-1370, 2010.

6. Moriishi K, Shoji I, Mori Y, Suzuki R, Suzuki T, Kataoka C, Matsuura Y. Involvement of PA28γ in the propagation of hepatitis C virus. Hepatology, 52: 411-420, 2010.

7. Sasase N, Kim SR, Kudo M, Kim KI, Taniguchi M, Imoto S, Mita K, Hayashi Y, Shoji I, El-Shamy A, Hotta H. Outcome and early viral dynamics with viral mutation in PEG-IFN/RBV therapy for chronic hepatitis in patients with high viral loads of serum HCV RNA genotype 1b. Intervirology, 53(1): 49-54, 2010.

8. Kim SR, Imoto S, Kudo M, Nakajima T, Ando K, Mita K, Fukuda K, Hong HS, Lee YH, Nakashima K, Shoji I, Nagano-Fujii M, Hotta H, Hayashi Y. Autoimmune thrombocytopenic purpura during pegylated interferon alpha treatment for chronic hepatitis C. Intern Med, 49(12): 1119-1122, 2010.

9. Kim SR, Imoto S, Kudo M, Mita K, Taniguchi M, Kim KI, Sasase N, Shoji I, Nagano-Fujii M, El-Shamy A, Hotta H, Nagai T, Nagata Y, Hayashi Y. Double-filtration plasmapheresis plus IFN for HCV-1b patients with non-sustained virological response to previous combination therapy: early viral dynamics. Intervirology, 53(1): 44-48, 2010.

10. An C, Ide Y-H, Nagano-Fujii M, Kitazawa S, Shoji I, Hotta H. A transgenic mouse line with a 58-kb fragment deletion in chromosome 11E1 that encompasses part of the Fam20a gene and its upstream region shows growth disorder. Kobe J Med Sci, 55(4): 82-92, 2010.


2009


1. Kasai D, Adachi T, Deng L, Nagano-Fujii M, Sada K, Ikeda M, Kato N, Ide Y-H, Shoji I, Hotta H. HCV replication suppresses cellular glucose uptake through down-regulation of cell surface expression of glucose transporters. J Hepatol, 50: 883-894, 2009.

2. Bungyoku Y, Shoji I, Makine T, Adachi T, Hayashida K, Nagano-Fujii M, Ide Y-H, Deng L, Hotta H. Efficient production of infectious hepatitis C virus with adaptive mutations in cultured hepatoma. J Gen Virol, 90(7): 1681-1691, 2009.

3. Mohd-Ismail NK, Deng L, Sukumaran SK, Yu VC, Hotta H, Tan YJ. The hepatitis C virus core protein contains a BH3 domain that regulates apoptosis through specific interaction with human MCL-1. J Virol, 83(19): 9993-10006, 2009.

4. Amako Y, Sarkeshik A, Hotta H, Yates J 3rd, Siddiqui A. Role of Oxysterol Binding Protein in Hepatitis C Virus infection. J Virol, 83(18): 9237-9246, 2009.

5. Yanagi D, Garry V, Dadik R, Lindawati A, Eddy BW, Ismoedijanto, Kinoshita S, Hayashi Y, Hotta H, Osawa R, Kawabata M, Shirakawa T. Emergence of fluoroquinolone-resistant strain of Salmonella enterica serovar Typhi in Surabaya, Indonesia. Diagn Microbiol Infect Dis 64(4):422-426, 2009.

6. Hara H, Aizaki H, Matsuda M, Shinkai-Ouchi F, Inoue Y, Murakami K, Shoji I, Kawakami H, Matsuura Y, Lai MM, Miyamura T, Wakita T, Suzuki T Involvement of creatine kinase B in hepatitis C virus genome replication through interaction with the viral NS4A protein.J Virol, 83(10):5137-5147, 2009.

7. Suzuki R, Moriishi K, Fukuda K, Shirakura M, Ishii K, Shoji I, Wakita T, Miyamura T, Matsuura Y, Suzuki T. Proteasomal turnover of hepatitis C virus core protein is regulated by two distinct mechanisms: a ubiquitin-dependent mechanism and a ubiquitin-independent but PA28gamma-dependent mechanism.J Virol, 83(5):2389-2392, 2009.

8. Shimoji T, Murakami K, Sugiyama Y, Matsuda M, Inubushi S, Nasu J, Shirakura M, Suzuki T, Wakita T, Kishino T, Hotta H, Miyamura T, Shoji I. Identification of annexin A1 as a novel substrate for E6AP-mediated ubiquitylation. J Cell Biochem. 106(6):1123-1135, 2009.

9. Kim SR, Imoto S, Mita K, Taniguchi M, Sasase N, Muramatsu A, Kudo M, Kitai S, El-Shamy A, Hotta H, Hayashi Y. Pegylated interferon plus ribavirin combination therapy for chronic hepatitis C with high viral load of serum hepatitis C virus RNA, genotype 1b, discontinued on attaining sustained virological response at week 16 after onset of acute pancreatitis. Digestion, 79(1):36-39, 2009.

10. Utsumi T, Lusida MI, Yano Y, Nugrahaputra VE, Amin M, Juniastuti, Soetjipto, Hayashi Y, Hotta H. Complete genome sequence and phylogenetic relatedness of hepatitis B virus isolates in Papua, Indonesia. J Clin Microbiol,47(6):1842-1847, 2009.

11. Jiang D-P, Ide Y-H, Nagano-Fujii M, Shoji I, Hotta H. Single-point mutations of the M protein of a measles virus variant obtained from a patient with subacute sclerosing panencephalitis critically affect solubility and subcellular localization of the M protein and cell-free virus production. Microbes Infect, 11(4):467-475, 2009.


2008

1. Deng L, Adachi T, Kitayama K, Bungyoku Y, Kitazawa S, Ishido S, Shoji I, Hotta H. Hepatitis C virus infection induces apoptosis through a Bax-triggered, mitochondria-mediated, caspase-3-dependent pathway.J Virol, 82(21):10375-10385, 2008.

2. El-Shamy A, Nagano-Fujii M, Sasase N, Imoto S, Kim SR, Hotta H. Sequence variation in the hepatitis C virus NS5A protein predicts clinical outcome of pegylated interferon/ribavirin combination therapy. Hepatology, 48:38-47, 2008

3. Inubushi S, Nagano-Fujii M, Kitayama K, Tanaka M, An C, Yokozaki H, Yamamura H, Nuriya N, Kohara M, Sada K, Hotta H. Hepatitis C virus NS5A protein interacts with and negatively regulates the non-receptor protein-tyrosine kinase Syk. J Gen Virol, 89(5):1231-1242, 2008

4. Lusida M I, Nugrahaputra VE, Soetjipto, Handajani R, Nagano-Fujii M, Sasayama M, Utsumi T, Hotta H. Novel subgenotypes of hepatitis B virus genotypes C and D in Papua, Indonesia. J Clin Microbiol, 46(7):2160-2166, 2008.

5. Sasase N, Kim SR, Kim KI, Taniguchi M, Imoto S, Mita K, Hotta H, Shoji I, El-Shamy A, Kawada N, Kudo M, Hayashi Y. Usefulness of new immuno-radiometric assay of HCV core antigen to predict virological response during PEG-IFN/RBV combination therapy for chronic hepatitis with high viral loads of serum HCV RNA genotype 1b. Intervirology, 51 Suppl 1:70-75. 2008.

6. Murakami K, Kimura T, Osaki M, Ishii K, Miyamura T, Suzuki T, Wakita T, Shoji I. Virological characterization of the HCV JFH-1 strain in lymphocytic cell lines. J Gen Virol, 89, 1587-1592, 2008.

7. Goto E, Mito-Yoshida M, Uematsu M, Aoki M, Matsuki Y, Ohmura-Hoshino M, Hotta H, Miyagishi M, Ishido S. An excellent monitoring system for surface ubiquitination-induced internalization in mammals. PLoS ONE 3(1):e1490, 2008.

8. Murakami K, Inoue Y, Hmwe SS, Omata K, Hongo T, Ishii K, Yoshizaki S, Aizaki H, Matsuura T, Shoji I, Miyamura T, Suzuki T. Dynamic behavior of hepatitis C virus quasispecies in a long-term culture of the three-dimensional radial-flow bioreactor system. J Virol Methods, 148, 174-181, 2008.

9. 金守良、井本勉、婦木秀一、金啓二、谷口美幸、長野基子、堀田博、勝二郁夫、寒原芳浩、前川陽子、工藤正俊、林祥剛. 1b型高ウイルス量高齢者型慢性肝炎に対するPEG IFN2bリバビリン治療(併用療法)の検討. 肝臓 49, 145-152, 2008.


2007

1. Otaki M, Jiang D-P, Sasayama M, Nagano-Fujii M, Hotta H. Generation of recombinant adenovirus expressing siRNA against the L mRNA of measles virus and subacute sclerosing panencephalitis virus. Microbiol Immunol, 51(10): 985-991, 2007

2. Nishise Y, Saito T, Sugahara K, Ito J, Saito K, Togashi H, Nagano-Fujii M, Hotta H, Kawata S. Risk of hepatocellular carcinoma and secondary structure of hepatitis C virus (HCV) NS3 protein amino-terminus among patients infected with HCV subtype 1b. J Infect Dis, 196(7):1006-1009, 2007

3. El-Shamy A, Sasayama M, Nagano-Fujii M, Sasase N, Imoto S, Kim S R, and Hotta H. Prediction of efficient virological response to pegylated interferon/ribavirin combination therapy by NS5A sequences of hepatitis C virus and anti-NS5A antibodies in pretreatment sera. Microbiol Immunol, 51(4):471-482, 2007.

4. Shirakura M, Murakami K, Ichimura T, Suzuki R, Shimoji T, Fukuda K, Abe K, Sato S, Fukasawa M, Yamakawa Y, Nishijima M, Moriishi K, Matsuura Y, Wakita T, Suzuki T, Howley PM, Miyamura T, Shoji I. The E6AP ubiquitin ligase mediates ubiquitylation and degradation of hepatitis C virus core protein. J.Virol, 81, 1174-1185, 2007.

5.Matsuki Y, Ohmura-Hoshino M, Goto E, Aoki M, Mito-Yoshida M, Uematsu M, Hasegawa T, Koseki H, Ohara O, Nakayama M, Toyooka K, Matsuoka K, Hotta H, Yamamoto A, Ishido S. Novel regulation of MHC class II function in B cells.EMBO J, 26(3):846-54. 2007.

6. Suzuki T, Aizaki H, Murakami K, Shoji I, Wakita T. Molecular biology of hepatitis C virus. J Gastroenterol, 42, 411-23, 2007.

7. Lu L, Li C, Fu Y, Thaikruea L, Thongswat S, Maneekarn N, Apichartpiyakul C, Hotta H, Okamoto H, Netski D, Pybus O G, Murphy D, Hagedorn C H, and Nelson K E. Complete genomes for hepatitis C virus subtypes 6f, 6i, 6j and 6m:viral genetic diversity among Thai blood donors and infected spouses. J Gen Virol, 88:1505-1518, 2007.

8. Vallet S, Gouriou S, Nkontchou G, Hotta H, Vilerio M, Legrand-Quillien M C, Beaugrand M, Trinchet J C, Nousbaum J B, Deny P, Gaudy C, Goudeau A, Picard B, Payan C. Is hepatitis C virus NS3 protease quasispecies heterogeneity predictive of progression from cirrhosis to hepatocellular carcinoma? J Viral Hepat, 14(2):96-106, 2007.

9. Ohgimoto K, Ohgimoto S, Ihara T, Mizuta H, Ishido S, Ayata M, Ogura H, Hotta H. Difference in production of infectious wild-type measles and vaccine viruses in monocyte-derived dendritic cells. Virus Res, 123(1):1-8, 2007


2006

1. Nomura-Takigawa Y, Nagano-Fujii M, Deng L, Kitazawa S, Ishido S, Sada K, Hotta H. Non-structural protein 4A of Hepatitis C virus accumulates on mitochondria and renders the cells prone to undergoing mitochondria-mediated apoptosis. J Gen Virol, 87:1935-1945, 2006.

2. Deng L, Nagano-Fujii M, Tanaka M, Nomura-Takigawa Y, Ikeda M, Kato N, Sada K, Hotta H. NS3 protein of Hepatitis C virus associates with the tumour suppressor p53 and inhibits its function in an NS3 sequence-dependent manner. J Gen Virol, 87:1703-1713, 2006.

3. Tanaka M, Nagano-Fujii M, Deng L, Ishido S, Sada K, Hotta H. Single-point mutations of hepatitis C virus NS3 that impair p53 interaction and anti-apoptotic activity of NS3. Biochem Biophys Res Commun, 340 (3): 792-799, 2006.

4. Kim K.I, Kim SR, Sasase N, Taniguchi M, Harada S, Kinoshita K, Kim SH, Akimoto Y, Shikata M, Kimura N, Izawa S, Ohtani A, Nakao K, Motojima M, Kinoshita M, Hirai M, Ohzu M, Hirooka T, Nabeshima S, Ishii F, Tanaka K, Hotta H. 2'-,5'-Oligoadenylate synthetase response ratio predicting virological response to PEG-interferon-alpha2b plus ribavirin therapy in patients with chronic hepatitis C. J Clin Pharm Ther, 31(5):441-446, 2006

5. Yonashiro R, Ishido S, Kyo S, Fukuda T, Goto E, Matsuki Y, Ohmura-Hoshino M, Sada K, Hotta H, Yamamura H, Inatome R, Yanagi S. A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics. EMBO J, 25(15):3618-3626, 2006

6. Ohmura-Hoshino M, Goto E, Matsuki Y, Aoki M, Mito M, Uematsu M, Hotta H, Ishido S. A novel family of membrane-bound e3 ubiquitin ligases. J Biochem, 140(2) :147-154, 2006

7. Ohmura-Hoshino M, Matsuki Y, Aoki M, Goto E, Mito M, Uematsu M, Kakiuchi T, Hotta H, Ishido S. Inhibition of MHC class II expression and immune responses by c-MIR. J Immunol, 177(1):341-354, 2006

8. Hotta H, Nihei K, Abe Y, Kato S, Jiang D-P, Nagano-Fujii M, Sada K. Full-length sequence analysis of subacute sclerosing panencephalitis (SSPE) virus, a mutant of measles virus, isolated from brain tissues of a patient shortly after onset of SSPE. Microbiol Immunol, 50(7):525-534, 2006

9. Otaki M, Sada K, Kadoya H, Kato S, Nagano-Fujii M, Hotta H. Inhibition of measles virus and subacute sclerosing panencephalitis virus by RNA interference. Antiviral Res, 70: 105-111, 2006

10. Inoue M, Uga S, Oda T, Rai SK, Vesey G, Hotta H. Physical and biochemical properties of Cryptosporidium oocysts change with incubation period in various circumstances. Water Res, 40(5):881-886, 2006


2005

1. Hidajat, R., Nagano-Fujii, M., Deng, L., Tanaka, M., Takigawa, Y., Kitazawa, S., and Hotta, H.: Hepatitis C virus NS3 protein interacts with ELKS-d and ELKS-a, members of a novel protein family involved in intracellular transport and secretory pathways. J. Gen. Virol., 86:2197-2208, 2005.

2. Qu, X., Miah, S. M., Hatani, H., Okazaki, M., Hori-Tamura, N., Yamamura, H. Hotta, H., and Sada, K.: Selective inhibition of FcepsilonRI-mediated mast cell activation by the truncation variant of Cbl-b related to the rat model of type 1 diabetes mellitus. J. Biochem., 137:711-720, 2005.

3. Kadoya, H., Nagano-Fujii, M., Deng, L., Nakazono, N., and Hotta, H.: Nonstructural proteins 4A and 4B of hepatitis C virus transactivate the Interleukin 8 promoter. Microbiol. Immunol., 49(3), 265-273, 2005.


2004

1. Taguchi, T., Nagano-Fujii, M., Akutsu, M., Kadoya, H., Ohgimoto, S., Ishido, S., and Hotta, H.: Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of interferon in an ISDR-independent manner. J. Gen. Virol., 85:959-969, 2004.

2. Uchida, D., Hatakeyama, S., Matsushima, A., Han, H., Ishido, S., Hotta, H., Kudoh, J., Shimizu, N., Doucas, V., Nakayama, K.I., Kuroda, N., and Matsumoto, M.: AIRE Functions Asan E3 Ubiquitin Ligase. J. Exp. Med., 199(2):167-172, 2004.

3. Hotta, H., Taguchi, T., Akutsu, M., and Nagano-Fujii, M.: HCV NS5A interacts with 2',5'-oligoadenylate synthetase and inhibits interferon activity. In: Viral Hepatitis and Liver Disease, 387-388,2004.

4. Takigawa, Y., Nagano-Fujii, M., Deng, L., Hidajat, R., Tanaka, M., Mizuta, H., and Hotta, H.: Suppression of hepatitis C virus replicon by RNA interference directed against the NS3 and NS5B regions of the viral genome. Microbiol. Immunol., 48(8): 591-598, 2004.

5. Hidajat, R., Nagano-Fujii, M., Deng, L., and Hotta, H.: Cleavage of the hepatitis C virus NS5A protein by caspase-3 in the interferon sensitivity-determining region in a sequence-dependent manner. Kobe J. Med. Sci., 50:153-166, 2004.


2003

1. Goto, E., Ishido, S., Sato, Y., Ohgimoto, S., Ohgimoto, K., Nagano-Fujii, M., and Hotta, H.: c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and 2 and has similar activity. J. Biol. Chem., 278(17): 14657-14668, 2003

2. Ogata, S., Florese, R.H., Nagano-Fujii, M., Hidajat, R., Deng, L., Ku, Y., Yoon, S., Saito, T., Kawata, S., and Hotta, H.: Identification of hepatitis C virus (HCV) subtype 1b strains that are highly, or only weakly, associated with hepatocellular carcinoma on the basis of secondary structure of an amino-terminal portion of the HCV NS3 protein. J. Clin. Microbiol., 41(7): 2835-2841, 2003.

3. Oka, K., Nagano-Fujii, M., Yoshida, I., Hidajat, R., Deng, L., Akutsu, M. and Hotta, H.: Hepatitis C virus core protein selectively inhibits synthesis and accumulation of p21/Waf1 and certain nuclear proteins. Microbiol. Immunol., 47(6):429-438, 2003

4. Lusida, M.I., Surayah, Sakugawa, H., Nagano-Fujii, M., Soetjipto, Mulyanto, Handajani, R., Boediwarsono, Setiawan, P.B., Nidom, C.A., Ohgimoto, S., and Hotta, H.: Genotype and subtype analyses of hepatitis B virus (HBV) and possible co-infection of HBV and hepatitis C virus (HCV) or hepatitis D virus (HDV) in blood donors, patients with chronic liver disease and patients on hemodialysis in Surabaya, Indonesia. Microbiol. Immunol., 47(12): 969-975, 2003

5. Inoue, M., Rai, S.K., Oda, T., Kimura, K., Nakanishi, M., Hotta, H., and Uga, S.: A new filter-eluting solution that facilitates improved recovery of Cryptosporidium oocysts from water. J. Microbiol. Methods, 55: 679-686, 2003

6. 石戸聡、後藤栄治、松木洋平、佐藤祐也、堀田博「新たな免疫抑制性E3ユビキチンリガーゼファミリー」Molecular Medicine,40:312-320, 2003.


2002

1. Ishido, S., RE, Means., Xavier, Alvarez. and Jae, U. Jung.: Multiple endocytic tranfficking pathways of MHC class I molecules induced by a Herpesvirus protein. The EMBO J., 21(7) :1638-1649, 2002.

2. Itoh, M., Okuno, Y., and Hotta, H.: Comparative analysis of serum antibody titers against measles virus in vaccinated and naturally infected Japanese individuals of different age groups.  J. Clin. Microbiol., 40:1733-1738, 2002.

3. Ogata, S., Ku, Y., Yoon, S., Makino, S., Nagano-Fujii, M., and Hotta, H.: Correlation between secondary structure of an amino-terminal portion of the nonstructural protein 3 (NS3) of hepatitis C virus and development of hepatocellular carcinoma. Microbiol. Immunol., 46(8): 549-554, 2002.

4. Ogata, S., Nagano-Fujii, M., Ku, Y., Yoon, S., Hotta, H.: Comparative sequence analysis of the core protein and its frameshift product, the F protein, of hepatitis C virus subtype 1b strains obtained from patients with and without hepatocellular carcinoma. J. Clin. Microbiol., 40(10), 3625-3630, 2002.

5.Tong, W.Y., Nagano-Fujii, M., Hidajat, R., Deng, L., Takigawa, Y., Hotta, H.: Physical interaction between hepatitis C virus NS4B protein and CREB-RP/ATF6b. Biochem. Biophys. Res. Commun., 299, 366-372, 2002.

6.Florese, R., Nagano-Fujii, M., Iwanaga, Y., Hidajat, R., Hotta, H.: Inhibition of protein synthesis by the nonstructural proteins NS4A and NS4B of hepatitis C virus. Virus Res., 90, 119-131, 2002.

7.Ogata, S., Ku, Y., Yoon, S., Makino, S., Nagano-Fujii, M., Hotta, H.: Correlation between secondary structure of an amino-terminal portion of the nonstructural protein 3 (NS3) of hepatitis C virus and development of hepatocellular carcinoma. Microbiol. Immunol., 46(8), 549-554, 2002.

8. Itoh, M.., Okuno, Y., and Hotta, H.: Comparative analysis of serum antibody titers against measles virus in vaccinated and naturally infected Japanese individuals of different age groups. J. Clin. Microbiol., 40, 1733-1738, 2002.

9. 石戸聡「KSHVによる免疫回避機構」臨床免疫37(3): 322-327, 2002.

10. 石戸聡、後藤栄治、佐藤祐也、堀田博「ウイルスによる抗原提示抑制機構」蛋白質核酸酵素47(16) 2085-2390, 2002.


2001

1. Yoshida, I. Oka, K. Hidajat, R. Nagano-Fujii, M. Ishido, S. and Hotta, H.: Inhibition of p21/Waf1/Cip1/Sdi1 expression by hepatitis C virus core protein. Microbiol. Immunol., 45(10): 689-97, 2001

2. Lusida, MI. Nagano-Fujii, M. Nidom, CA. Soetjipto, Handajani, R. Fujita, T. Oka, K. and Hotta, H.: Correlation between mutations in the interferon sensitivity-determining region of NS5A protein and viral load of hepatitis C virus subtypes 1b, 1c, and 2a. J Clin Microbiol., 39(11): 3858-64, 2001

3. Takamatsu, M. Fujita, T. and Hotta, H.: Suppression of serum starvation-induced apoptosis by hepatitis C virus core protein. Kobe J. Med. Sci., 47:97-112, 2001.

4. Ono, K.. Tsuji, H. Rai, K. S. Yamamoto, A.. Masuda, K. Endo, T. Hotta, H. Kawamura, T. and Uga, S.: Contamination of river water by Cryptosporidium parvum oocysts in western Japan. Appl. Environ. Microbiol.,  67(9): 3832-3836, 2001.

5. Ono, K., Rai, K. S., Chikahira, M., Fujimoto, T., Shibata, H., Wada, Y.,Tsuji, H., Oda, Y., Rai, G., Shrestha, D. C., Masuda, K., Shrestha, G. H., Matsumura, T., Hotta, H., Kawamura, T. and Uga. S.: Seasonal distribution of enteropathogens detected from diarrheal stool and water samples collected in Kathmandu, Nepal.  Southeast Asian J. Trop. Med. Public Health, 32(3): 520-526, 2001

6. Ohgimoto, S. Ohgimoto, K. Niewiesk, S. Klagge, I. M. Pfeuffer, J. Johnston, ICD. Schneider-Schaulies, J. Weidmann, A. ter Meulen, V. Schneider-Schaulies, S.: The haemagglutinin protein is an important determinant of measles virus tropism for dendritic cells in vitro.  J. Gen. Virol., 82: 1835-1844, 2001.


2000

1. Wang,, F., Yoshida, I., Takamatsu, M., Ishido, S., Fujita, T., Oka, K. and Hotta, H.: Complex formation between hepatitis C virus core protein and p21Waf1/Cip1/Sdi1. Biochem. Biophys. Res. Commun. 273(2):479-484, 2000.

2. Ishido, S., Fujita, T., and Hotta, H.: Possible involvement of the NS3 protein of hepatitis C virus in hepatocarcinogenesis: its interaction with the p53 tumor suppressor. In: Methods in Molecular Medicine, The Humana Press, Inc. pp. 37-55, 2000.

3. Song, J., Wang, F., Florese, R., Fujii, M. and Hotta, H.: Nuclear localization and intramolecular cleavage of N-terminally deleted NS5A protein of hepatitis C virus. Virus Res., 69:109-117, 2000.

4. Lusida, M. I., Soetjipto, Handajani, R., Nidom, C. A., Soemarto, Darmadi, S., Adi, P., Fujii, M., Fujita, T., Ishido, S., and Hotta, H.: Viral load in Indonesian patients with chronic liver disease and in blood donors infected with different subtypes of hepatitis C virus. Jpn. J. Infect. Dis., 53: 67-69, 2000.

5. Handajani, R., Soetjipto, Lusida, I. M., Suryohudoyo, P., Adi, P., Setiawan, P. B., Nidom, C. A., Soemarto, R., Katayama, Y., Fujii, M. and Hotta, H.: Prevalence of GB virus C/ hepatitis G virus infection among various populations in Surabaya, and identification of novel groups of sequence variants. J. Clin. Microbiol., 38(2):662-668, 2000.

6. Ishido, S. Choi, JK. Lee, BS. Wang, C. DeMaria, M. Johnson, RP. Cohen, GB. and Jung, JU.: Inhibition of natural killer cell-mediated cytotoxicity by Kaposi's sarcoma-associated herpesvirus K5 protein. Immunity, 13(3):365-374, 2000.

7. Ishido, S. Wang, C. Lee, BS. Cohen, GB. and Jung, JU.: Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins. J Virol., 74(11): 5300-5309, 2000.

8. Ueyama, T., Kawashima, S., Sakoda, T., Rikitake, Y., Ishida, T., Kawai, M., Yamashita, T., Ishido, S., Hotta, H. and Yokoyama, M.: Requirement of activation of the extracellular signal-regulated kinase cascade in myocardial cell hypertrophy. J. Mol. Cell. Cardiol., 32(6):947-960, 2000.

9. Rikitake, Y., Kawashima, S., Yamashita, T., Ueyama, T., Ishido, S., Hotta, H., Hirata, K. and Yokoyama, M.: Lysophatidylcholine inhibits endothelial cell migration and proliferation via inhibition of the extracellular signal-regulated kinase pathway. Arterioscler. Thromb. Vasc. Biol., 20(4):1006-1012, 2000.

10.Katayama, Y., Hirano, A. and Wong, T. C.: Human receptor for measles virus (CD46) enhances nitric oxide production and restricts virus replication in mouse macrophages by modulating production of alpha/beta interferon.  J. Virol., 74(3): 1252-1257, 2000.

11. 堀田博「C型肝炎ウイルス非構造タンパク質NS5Aによるインターフェロン抗ウイルス活性の抑制」臨床成人病30(10), 100-102, 2000.


1999

1. Song, J., Fujii, M., Wang, F., Itoh, M. and Hotta, H.: The NS5A protein of hepatitis C virus partially inhibits the antiviral activity of interferon. J. Gen. Virol., 80(4):879-886, 1999.

2. Sakugawa, H., Nakasone, H., Nakayoshi, T., Kawakani, Y., Miyazato, S., Kinjo, F., Saito, A., Ma, S.-P., Hotta, H. and Kinoshita, M.: Heaptitis delta virus genotype IIb predominates in an endemic area, Okinawa, Japan. J. Med. Virol., 58(4):366-372, 1999.

3. Apichartpiyakul, C., Apichartpiyakul, N., Urwijitaroon, Y., Gray, J., Natpratan, C., Katayama, Y., Fujii, M., Hotta, H.: Seroprevalence and subtype distribution of hepatitis C virus among blood donors and intravenous drug users in Northern/Northeastern Thailand. Jpn. J. Infect. Dis., 52:121-123, 1999.

4 Hirano, A., Yang, Z. P., Katayama, Y., Korte-Sarfaty, J. and Wong, T. C.: Human CD46 enhances nitric oxide production in mouse macrophages in response to meales virus infection in the presence of gamma interferon: Dependence on the CD46 cytoplasmic domains.  J. Virol., 1999: 73(6): 4776-4785

5. 堀田博「C型肝炎ウイルスのMolecular Virology Update-がん化関連機構を中心に-」最新医学54(8), 34-41, 1999.


1998

1. Ishido, S. and Hotta, H.: Complex formation of the nonstructural protein 3 of hepatitis C virus with the p53 tumor suppressor. FEBS Lett., 438:258-262, 1998.

2. Ishido, S., Fujita, T. and Hotta, H.: Complex formation of NS5B with NS3 and NS4A proteins of hepatitis C virus. Biochem. Biophys. Res. Commun., 244(1):35-40, 1998.

3. Itoh, M., Hotta, H. and Homma, M.: Increased induction of apoptosis by a Sendai virus mutant is associated with attenuation of mouse pathogenicity. J. Virol., 72(4): 2927-2934, 1998.

4. Katayama, Y., Tajiri H., Tada, K., Okada S., Tong W.-Y., Ishido, S. and Hotta, H.: Follow-up study of hypervariable region sequences of the hepatitis C virus genome in an infant with delayed anti-HCV antibody resposes. Microbiol. Immunol. 42(1), 75-79, 1998.

5. Etani, Y., Tajiri, H., Tada, K., Sawada, A., Kozaiwa, K., Okada, S. and Hotta, H.: Molecular diagnosis and liver histology of children with mother-to-child transmitted hepatitis C virus. J. Pediatr., 133:588, 1998.

6. Katayama, Y., Kohso, K., Nishimura, A., Tatsuno, Y., Homma, M. and Hotta, H.: Detection of measles virus mRNA from autopsied human tissues. J. Clin. Microbiol., 36(1):299-301, 1998.


1997

1. Muramatsu, S., Ishido, S., Fujita, T., Itoh, M. and Hotta, H.: Nuclear localization of the NS3 protein of hepatitis C virus and factors affecting the localization. J. Virol. 71(7):4954-4961, 1997.

2. Ishido, S., Muramatsu, S., Fujita, T., Iwanaga, Y., Tong, W-Y., Katayama,Y., Itoh, M. and Hotta, H.: Wild-type, but not mutant-type, p53 enhances nuclear accumulation of the NS3 protein of hepatitis C virus. Biochem. Biophys. Res. Commun. 230: 431-436, 1997.

3. Itoh, M., Isegawa, Y., Hotta, H. and Homma, M.: Isolation of an avirulent mutant of Sendai virus with two amino acid mutations from a highly virulent fieldstrain through adaptation to LLC-MK2 cells. J. Gen. Virol., 78:3207-3217, 1997.

4. Katayama, Y., Shibahara, K., Kohama, T., Homma, M. and Hotta, H.: Molecular epidemiology and changing distribution of genotypes of measles virus field strains in Japan. J. Clin. Microbiol. 35(10):2651-2653, 1997.

5. Katayama,Y., Apichartpiyakul, C., Handajani, R., Ishido, S. and Hotta, H.: GB virus C/hepatitis G virus (GBV-C/HGV) infection in Chiang Mai, Thailand, and identification of variants on the basis of 5'-untranslated region sequences. Arch. Virol., 142:2433-2445, 1997.

6. Katayama, Y., Shibahara, K., Kohama, T., Homma, M. and Hotta, H.: Molecular epidemiology and changing distribution of genotypes of measles virus field strains in Japan. J. Clin. Microbiol. 35(10):2651-2653, 1997.

7. Hotta, H., Kemapunmanus, M., Apichartpiyakul, C., Soetjipto, Handajani, R. and Barzaga, N.G.: Differential distribution of hepatitis C virus subtype in Asia: Comparative study among Thailand, Indonesia, the Philippines and Japan. SEA J. Trop. Med. Publ. Health, 28(Suppl 3):23-31, 1997.

8. Nidom, C. A., Soetjipto, Handajani, R., Lusida, M. I., Song, J., Katayama, Y. and Hotta, H.: Detection of hepatitis TT virus among patients on maintenance hemodialysis in Surabaya, Indonesia: A preliminary study. ICMR Annals, 17:1-6, 1997.

9. 堀田博、石戸聡 「発癌ウイルスとしてのC型肝炎ウイルスの意義」臨床科学. 33(8):980-986, 1997.


1996

1. Fujita, T., Ishido, S., Muramatsu, S., Itoh, M. and Hotta, H.: Suppression of actinomycin D-induced apoptosis by the NS3 protein of hepatitis C virus. Biochem. Biophys. Res. Commun. 229:825-831, 1996.

2. Hara I., Hotta H., Sato N., Eto H., Arakawa S. and Kamidono S.: Rejection of mouse renal cell carcinoma elicited by local secretion of interleukin-2. Jpn. J. Cancer Res. 87: 724-729, 1996.

3. Soetjipto, Handajani, R., Lusida, M. I., Darmadi, S., Adi, P., Soemarto, Ishido, S., Katayama, Y. and Hotta, H.: Differential prevalence of hepatitis C virus subtypes in healthy blood donors, patients on maintenance hemodialysis and patients with hepatocellular carcinoma in Surabaya, Indonesia. J. Clin. Microbiol. 34(12): 2875-2880, 1996.

4. Doi, H., Apichartpiyakul, C., Ohba, K., Mizokami, M. and Hotta, H.: Hepatitis C virus (HCV) subtype prevalence in Chiang Mai, Thailand, and identification of novel subtypes of HCV major type 6. J. Clin. Microbiol. 34(3): 569-574, 1996.

5. Katayama, Y., Barzaga, N. G., Alipio, A., Soetjipto, Doi, H., Ishido, S. and Hotta, H.: Genotype analysis of hepatitis C virus among blood donors and inmates in Metro Manila, The Philippines. Microbiol. Immunol. 40(7): 525-529, 1996.

6. Darmadi, S., Soetjipto, Handajani, R., Lusida, M. I., Soemarto, R., Sakugawa, H., Ishido, S. and Hotta, H.: Hepatitis C virus infection-associated markers in sera from blood donors in Surabaya, Indonesia. Microbiol. Immunol. 40(5): 401-405,1996.

7. Ke, W-M., Tan, D., Li, J-G., Izumi, S., Shinj, S., Hotta, H. and Yao, J-L: Consecutive evaluation of immunoglobulin M and G antibodies against hepatitis E virus. J. Gastroenterol. 31(12):818-822, 1996.

8. Mikami S., Kawashima S., Kanazawa K., Hirata K., Katayama Y., Hotta H., Hayashi Y., Ito H. and Yokoyama M.: Expression of nitric oxide synthase in a murine model of viral myocarditis induced by coxsackievirus B3. Biochem. Biophys. Res. Commun. 220: 938-989, 1996.

9. 堀田博 「HCVの分子疫学ーウイルス遺伝子の多様性と臨床疫学的意義」 医学のあゆみ177: 1235-1241, 1996.